CN107308102A - A kind of solid type probiotics mouthwash and preparation method thereof and application method - Google Patents
A kind of solid type probiotics mouthwash and preparation method thereof and application method Download PDFInfo
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- CN107308102A CN107308102A CN201710558008.3A CN201710558008A CN107308102A CN 107308102 A CN107308102 A CN 107308102A CN 201710558008 A CN201710558008 A CN 201710558008A CN 107308102 A CN107308102 A CN 107308102A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
- A61K8/022—Powders; Compacted Powders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention provides a kind of solid type probiotics mouthwash and its preparation and application, the mouthwash is mainly made up of the component of following parts by weight：0.1 5 parts of powder filled dose 1 30 parts, 2 70 parts of disintegrant, 1 20 parts of probiotics, 1 20 parts of prebiotics and D-lactic acid zinc.Compared with common liquid-type probiotics mouthwash, probiotics mouthwash of the present invention is solid type, it is not necessary to additionally add preservative, will not produce inhibitory action to the probiotics in the mouthwash, and the mouthwash dispels halitosis and the ability of smoke is strong, and rapid-action, length of holding time.
Description
Technical field
The present invention relates to mouthwash field, in particular to a kind of solid type probiotics mouthwash and preparation method thereof
And application method.
Background technology
It is difficult to remove two large problems common when halitosis and smoke are oral cleanings.Although halitosis and smoke will not be to human bodies
Health produces influence, but brings great puzzlement to human communication.
At present, the main method for removing halitosis is that probiotics is added in mouthwash, so as to suppress porphyromonas in oral cavity
The growth of the halitosis pathogenic bacteria such as monad.But there is following defect in the mouthwash of existing addition probiotics：
(1) mouthwash be liquid, belong to the product of easy microbiological contamination, wherein certainly will preservative or bacteriostatic agent be added, these into
Divide itself that there is broad-spectrum antibacterial action, destruction can be produced to oral cavity flora, obstruction probiotics plays curative effect；
(2) existing mouthwash removes halitosis and the effect of smoke is poor.
In view of this, it is special to propose the present invention.
The content of the invention
The first object of the present invention is to provide a kind of solid type probiotics mouthwash, and the mouthwash is solid type, without
It is extra to add preservative, probiotics will not be hindered to play curative effect.
The second object of the present invention is to provide a kind of preparation method of the mouthwash, and this method can be quickly and easily
Above-mentioned mouthwash is prepared, is easy to large-scale production.
The third object of the present invention is to provide a kind of powder spray bottle, and the powder spray bottle can be easily by powdered mouthwash
Spray.
The fourth object of the present invention is the method for providing a kind of above-mentioned solid type probiotics mouthwash of use, passes through the party
Method can simply and rapidly eliminate oral peculiar smell.
In order to realize the above-mentioned purpose of the present invention, spy uses following technical scheme：
A kind of solid type probiotics mouthwash, the mouthwash is mainly made up of the component of following parts by weight：It is powder filled
0.1-5 parts of 1-30 parts of agent, 2-70 parts of disintegrant, 1-20 parts of probiotics, 1-20 parts of prebiotics and D-lactic acid zinc.
The above-mentioned probiotics mouthwash of the present invention is solid type, on the one hand, the water content of the mouthwash is extremely low, and bacterium is difficult to
Grow, and in use do not contact the solid type mouthwash with the oral area of user directly, it is not easy to be contaminated, because
This, it is not necessary to preservative is additionally added, so as to avoid destruction of the preservative to probiotics in mouthwash, prevents probiotics from losing
Effect.On the other hand, disintegrant is added in solid type mouthwash of the present invention, rapidly can be disintegrated in water, formation can be straight
Connect the liquid-type mouthwash used, convenient use.
In certain embodiments, the mouthwash is mainly made up of the component of following parts by weight：Powder filled dose 5-30 parts,
1-3 parts of 10-70 parts of disintegrant, 3-20 parts of probiotics, 3-20 parts of prebiotics and D-lactic acid zinc.
In certain embodiments, the mouthwash is mainly made up of the component of following parts by weight：Powder filled dose of 15-30
3-5 parts of part, 40-70 parts of disintegrant, 15-20 parts of probiotics, 15-20 parts of prebiotics and D-lactic acid zinc.
In certain embodiments, the mouthwash is mainly made up of the component of following parts by weight：Powder filled dose 5 parts, collapse
Solve 1 part of 10 parts of agent, 3 parts of probiotics, 3 parts of prebiotics and D-lactic acid zinc.
In certain embodiments, the mouthwash is mainly made up of the component of following parts by weight：Powder filled dose 15 parts, collapse
Solve 3 parts of 40 parts of agent, 15 parts of probiotics, 15 parts of prebiotics and D-lactic acid zinc.
In certain embodiments, the mouthwash is mainly made up of the component of following parts by weight：Powder filled dose 30 parts, collapse
Solve 5 parts of 70 parts of agent, 20 parts of probiotics, 20 parts of prebiotics and D-lactic acid zinc.
In some embodiments, the disintegrant is made up of acidic components and basic component；Preferably, by weight
Meter, the disintegrant is made up of 1-50 parts of basic components and 1-20 parts of acidic components；Or, by weight, the disintegrant
It is made up of 8-50 parts of basic components and 2-20 parts of acidic components；Or, by weight, the disintegrant is by 30-50 parts of alkalescence
Component and 10-20 parts of acidic components compositions；It is highly preferred that the disintegrant is made up of 8 parts of basic components and 2 parts of acidic components；
Or, the disintegrant is made up of 30 parts of basic components and 10 parts of acidic components；Or, the disintegrant is by 50 parts of basic components
With 20 parts of acidic components compositions.
In some embodiments, the basic component is selected from sodium carbonate, potassium carbonate, sodium acid carbonate, saleratus, carbonic acid
One or more in calcium or calcium bicarbonate, the acidic components in citric acid, malic acid, tartaric acid or fumaric acid one
Plant or a variety of；Most preferably, the basic component is sodium acid carbonate, and the acidic components are citric acid.
In some embodiments, the powder filled material is selected from microcrystalline cellulose, silica, calcium monohydrogen phosphate, burnt phosphorus
One or more in sour calcium, PVP, polyethylene glycol, maltodextrin, lauryl sodium sulfate.
In some embodiments, the probiotics is selected from lactobacillus paracasei, Lactobacillus salivarius, bifidobacterium lactis, hair
One or more in kefir milk bacillus, streptococcus salivarius；Preferably, the probiotics is lactobacillus paracasei.
In some embodiments, the prebiotics is selected from FOS, oligomeric maltose, lactulose, galactolipin and chrysanthemum
Powder；Preferably, the prebiotics is FOS.
Species of the above-mentioned solid type probiotics mouthwash of the present invention to disintegrant, powder filled material, probiotics and prebiotics
It is defined and preferably.It has been found, unexpectedly, probiotics and prebiotics, powder filled dose of microcrystalline cellulose or dioxy
Alkaline components NaHCO in SiClx, disintegrant3And D-lactic acid zinc compounding can play a part of Synergistic, lift institute
Effect that mouthwash removes removing abnormal flavor in oral cavity is stated, the time that is rapid-action, maintaining breath freshening is long.Mouthwash with only using probiotics
Compare, mouthwash of the present invention eliminates halitosis and smoke is remarkably reinforced.
In some embodiments, the mouthwash also includes glycitols filler and/or sweetener；Preferably, by weight
Measure part meter, 0.1-40 parts of the glycitols filler, described sweetener 0.01-0.5 parts；Or, the glycitols filler 5-
30 parts, described sweetener 0.1-0.5 parts；Or, described, 10-20 parts of the glycitols filler, the sweetener 0.1-0.2
Part；It is highly preferred that 5 parts of the glycitols filler, 0.05 part of the sweetener；Or, 15 parts of the glycitols filler, institute
State 0.2 part of sweetener；Or, 30 parts of the glycitols filler, 0.4 part of the sweetener.
In some embodiments, the glycitols filler is selected from sorbierite, maltitol, mannitol, antierythrite
With the one or more in xylitol；The one kind of the sweetener in STEVIA REBAUDIANA, glycine betaine, Abbas's sweet tea, Sucralose
Or it is a variety of.
The preparation method of the invention that above-mentioned mouthwash is also provided, the step of methods described includes mixing each raw material, preferably
Ground, the raw material is powder, it is highly preferred that the step of methods described also includes mixed material powder loading powder spray bottle.
The above method of the present invention can obtain aforesaid solid type probiotics mouthwash by simply mixing raw material, described
Method is easy to operate, simple and easy to apply, is adapted to large-scale production.In order to be more convenient the dissolving of subsequent solid type probiotics mouthwash,
Raw material in the method for the invention is preferably powder.
The present invention also provides a kind of powder spray bottle, and the powder spray bottle includes bottle and above-mentioned mouthwash, and the mouthwash is powder
Last shape.In some embodiment party, the powder spray bottle is in closed state when not in use, and powder is sprayed by spout when in use.
The present invention above-mentioned mouthwash is encased in powder spray bottle, when in use, can by shower nozzle directly will be powdered
Mouthwash sprays from bottle, without in use, powder spray bottle is in sealing state, it is to avoid microbiological contamination.Therefore, powder of the present invention is passed through
Spray bottle can conveniently and hygienically use aforesaid solid type mouthwash.
The invention further relates to a kind of method using above-mentioned solid type probiotics mouthwash, methods described includes will be described solid
Build probiotics mouthwash is dissolved in water, then is gargled with the water.Can quickly and efficiently it be disappeared by the above method of the present invention
Removing abnormal flavor in oral cavity and smoke.
Compared with prior art, beneficial effects of the present invention are：
1), probiotics mouthwash of the present invention is solid type, compared with liquid-type probiotics mouthwash, it is not necessary to extra
Preservative is added, inhibitory action will not be produced to the probiotics in the mouthwash.
2), solid type probiotics mouthwash of the present invention includes disintegrant, rapidly can be disintegrated in aqueous,
Liquid-type mouthwash is formed, is directly used.
3), the probiotics in solid type probiotics mouthwash of the present invention and prebiotics, NaHCO3, microcrystalline cellulose/
Silica and D-lactic acid zinc compounding use, the energy of halitosis and smoke is dispelled with Synergistic, the enhancing mouthwash
Power, and rapid-action, length of holding time.
Embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.It is unreceipted specific in embodiment
Condition person, the condition advised according to normal condition or manufacturer is carried out.Agents useful for same or the unreceipted production firm person of instrument, be
The conventional products that can be obtained by commercially available purchase.
Embodiment 1
Weigh the dusty raw materials of following parts by weight：
5 parts of microcrystalline cellulose；
NaHCO38 parts；
2 parts of citric acid；
3 parts of lactobacillus paracasei；
5 parts of xylitol；
3 parts of FOS；
1 part of D-lactic acid zinc；
0.01 part of Abbas's sweet tea；
Above-mentioned dusty raw materials are well mixed, and are fitted into powder spray bottle.
Embodiment 2
Weigh the dusty raw materials of following parts by weight：
15 parts of microcrystalline cellulose；
NaHCO330 parts；
10 parts of citric acid；
15 parts of lactobacillus paracasei；
15 parts of xylitol；
15 parts of FOS；
3 parts of D-lactic acid zinc；
0.3 part of glycine betaine；
Above-mentioned dusty raw materials are well mixed, and are fitted into powder spray bottle.
Embodiment 3
Weigh the dusty raw materials of following parts by weight：
30 parts of microcrystalline cellulose；
NaHCO350 parts；
20 parts of citric acid；
20 parts of lactobacillus paracasei；
30 parts of xylitol；
20 parts of FOS；
5 parts of D-lactic acid zinc；
0.5 part of STEVIA REBAUDIANA；
Above-mentioned dusty raw materials are well mixed, and are fitted into powder spray bottle.
Embodiment 4
Weigh the dusty raw materials of following parts by weight：
5 parts of silica 1；
NaHCO330 parts；
10 parts of citric acid；
15 parts of lactobacillus paracasei；
15 parts of xylitol；
15 parts of FOS
3 parts of D-lactic acid zinc；
0.3 part of glycine betaine；
Above-mentioned dusty raw materials are well mixed, and are fitted into powder spray bottle.
Comparative example 1
Weigh the dusty raw materials of following parts by weight：
15 parts of maltodextrin；
KHCO330 parts；
10 parts of citric acid；
15 parts of lactobacillus paracasei；
15 parts of xylitol；
0.3 part of glycine betaine；
Above-mentioned dusty raw materials are well mixed, and are fitted into powder spray bottle.
Comparative example 2
Weigh the dusty raw materials of following parts by weight：
15 parts of maltodextrin；
KHCO330 parts；
10 parts of citric acid；
15 parts of lactobacillus paracasei；
15 parts of xylitol；
15 parts of FOS；
0.3 part of glycine betaine；
Above-mentioned dusty raw materials are well mixed, and are fitted into powder spray bottle.
Comparative example 3
Commercially available Li Shidelin mouthwashes.
Experimental example 1
Select 60 groups of subjects with oral peculiar smell, be equally divided into six groups, every group of 10 people, using embodiment 1-4 and
Mouthwash described in comparative example 1-2 is gargled, and oral peculiar smell situation is scored before and after gargling, and calculates every group of subject
Average mark before and after gargling
Standards of grading are as follows：5- is very heavy, and 4- is heavier, and 3- has obvious halitosis taste, and 2- has light halitosis taste, and 1- is without halitosis
Taste.As a result it is as shown in table 1.
The mouthwash of table 1 is to dispelling the effect of subject oral cavity peculiar smell
| Before use | After use | |
| Embodiment 1 | 5 | 2.1 |
| Embodiment 2 | 5 | 1.7 |
| Embodiment 3 | 5 | 2.2 |
| Embodiment 4 | 5 | 2.0 |
| Comparative example 1 | 5 | 3.7 |
| Comparative example 2 | 5 | 3.4 |
Experimental example 2
20 halitosis patients are selected, is determined using halimeter implication testers after its oral peculiar smell, uses embodiment 2
The product is gargled, the 5min after gargling, 60min, determines oral peculiar smell again after 120min, its result is as shown in table 2：
The solid type probiotics mouthwash of table 2 dispels effect to halitosis
Experimental example 3
20 smoking personages are selected, two groups are equally divided into, one group uses mouthwash described in the embodiment of the present invention 2, and one group makes
Li Shidelin mouthwashes are used, its oral cavity smoke is determined with the method for hearing taste, pair using oral cavity smoke before and after mouthwash is evaluated
Than.
Evaluation is divided into 5 class：5- is very heavy, and 4- is heavier, and 3- has obvious smoke, and 2- has light smoke, 1- smoke smell frees, knot
Fruit is as shown in table 2.
The mouthwash of table 3 compares the effect of dispelling of smoke
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent
The present invention is described in detail with reference to foregoing embodiments for pipe, but it will be understood by those within the art that：Its
The technical scheme described in foregoing embodiments can still be modified, or to which part or all technical characteristic
Carry out equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention skill
The scope of art scheme.
Claims (10)
1. a kind of solid type probiotics mouthwash, it is characterised in that the mouthwash is mainly made up of the component of following parts by weight：
0.1-5 parts of powder filled dose 1-30 parts, 2-70 parts of disintegrant, 1-20 parts of probiotics, 1-20 parts of prebiotics and D-lactic acid zinc.
2. mouthwash according to claim 1, it is characterised in that the disintegrant is by acidic components and basic component group
Into；Preferably, by weight, the disintegrant is made up of 1-50 parts of basic components and 1-20 parts of acidic components；It is highly preferred that
The one kind or many of the basic component in sodium carbonate, potassium carbonate, sodium acid carbonate, saleratus, calcium carbonate or calcium bicarbonate
Kind, one or more of the acidic components in citric acid, malic acid, tartaric acid or fumaric acid；Most preferably, the alkali
Property component be sodium acid carbonate, the acidic components be citric acid.
3. mouthwash according to claim 1, it is characterised in that the powder filled material is selected from microcrystalline cellulose, dioxy
One or more in SiClx, calcium monohydrogen phosphate, calcium pyrophosphate, PVP, polyethylene glycol, maltodextrin, lauryl sodium sulfate；
Preferably, the powder stuffing taste microcrystalline cellulose or silica.
4. mouthwash according to claim 1, it is characterised in that the probiotics is selected from lactobacillus paracasei, saliva breast
One or more in bacillus, bifidobacterium lactis, lactobacillus fermenti, streptococcus salivarius；Preferably, the probiotics is secondary cheese
Lactobacillus.
5. mouthwash according to claim 1, it is characterised in that the prebiotics be selected from FOS, oligomeric maltose,
Lactulose, galactolipin and inulin；Preferably, the prebiotics is FOS.
6. mouthwash according to claim 1, it is characterised in that the mouthwash also include glycitols filler and/or
Sweetener；Preferably, by weight, 0.1-40 parts of the glycitols filler, described sweetener 0.01-0.5 parts；More preferably
Ground, one or more of the glycitols filler in sorbierite, maltitol, mannitol, antierythrite and xylitol；
One or more of the sweetener in STEVIA REBAUDIANA, glycine betaine, Abbas's sweet tea, Sucralose.
7. the preparation method of any one of the claim 1-6 mouthwashes, it is characterised in that methods described includes mixing each raw material
The step of conjunction, it is preferable that the raw material is powder, it is highly preferred that methods described also includes loading mixed material powder
The step of powder spray bottle.
8. a kind of powder spray bottle, it is characterised in that the powder spray bottle includes gargling described in bottle and claim any one of 1-6
Water, the mouthwash is powdered.
9. powder spray bottle according to claim 8, it is characterised in that the powder spray bottle is in closed state when not in use,
Powder is sprayed by spout when in use.
10. a kind of method that usage right requires any one of the 1-6 solid type probiotics mouthwash, it is characterised in that described
Method includes the solid type probiotics mouthwash being dissolved in water, then is gargled with the water.
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| CN109045071A (en) * | 2018-08-15 | 2018-12-21 | 珠海中科先进技术研究院有限公司 | A kind of composition that can mitigate halitosis and its application |
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Application publication date: 20171103 |