CN117100675A - Lactobacillus anhydrous dental tablet containing living bacteria and preparation method and application thereof - Google Patents
Lactobacillus anhydrous dental tablet containing living bacteria and preparation method and application thereof Download PDFInfo
- Publication number
- CN117100675A CN117100675A CN202310759117.7A CN202310759117A CN117100675A CN 117100675 A CN117100675 A CN 117100675A CN 202310759117 A CN202310759117 A CN 202310759117A CN 117100675 A CN117100675 A CN 117100675A
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- China
- Prior art keywords
- lactobacillus
- percent
- acid
- mesh sieve
- anhydrous dental
- Prior art date
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- 229940039696 lactobacillus Drugs 0.000 title claims abstract description 73
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- 239000003795 chemical substances by application Substances 0.000 claims abstract description 32
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- 150000007524 organic acids Chemical class 0.000 claims abstract description 11
- 239000000654 additive Substances 0.000 claims abstract description 7
- 230000000996 additive effect Effects 0.000 claims abstract description 7
- 235000016709 nutrition Nutrition 0.000 claims abstract description 7
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- 239000002245 particle Substances 0.000 claims description 54
- 238000007873 sieving Methods 0.000 claims description 38
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Abstract
The invention discloses a lactobacillus anhydrous dental tablet containing living bacteria, a preparation method and application thereof, wherein the lactobacillus anhydrous dental tablet containing living bacteria comprises the following components in proportion: 0.01 to 3 percent of live lactobacillus, 0.2 to 15 percent of nutrition additive, 5 to 22 percent of organic acid disintegrating agent, 10 to 25 percent of inorganic alkaline disintegrating agent, 6 to 40 percent of adhesive, 1.1 to 38 percent of lubricant, 0.6 to 7 percent of friction agent, 0.01 to 1.5 percent of foaming agent, 1.1 to 20 percent of sweetener and 0.01 to 2 percent of essence. The invention ensures that lactobacillus is dormant normally in proper environment by a water-free system, activates the activity of the lactobacillus when meeting water, simultaneously inhibits the active effect of pathogenic bacteria in the oral cavity by adding active lactobacillus strains, and adjusts the microecological balance of oral flora so as to achieve the effects of removing halitosis and refreshing breath for a long time.
Description
Technical Field
The invention relates to the technical field of oral care products, in particular to a lactobacillus anhydrous dental tablet containing living bacteria, and a preparation method and application thereof.
Background
With the development of social economy, the living standard of people is improved, the oral health is increasingly valued by the public, the consumption scale of oral care products is gradually enlarged, the requirements of people on the types of oral products are more and more increased, and particularly, the requirements on the products with lactobacillus efficacy are more and more increased, and the requirements on the mouth feel of dental films are more and more increased. The lactobacillus raw materials added into the oral products containing lactobacillus on the market at present are all dead bacteria which are inactivated, and the lactobacillus raw materials run off along with clear water of mouthwash after mechanical tooth brushing, and do not play any role even if the lactobacillus raw materials remain in the oral cavity, so that the lactobacillus raw materials cannot compete with harmful bacteria in the oral cavity to repel the harmful bacteria in the oral cavity, and the oral cavity is maintained in the true sense, so that the effects of cleaning the oral cavity and nursing the oral cavity are insufficient.
Disclosure of Invention
The invention aims to provide a lactobacillus anhydrous dental tablet containing living bacteria, a preparation method and application thereof, wherein the lactobacillus is ensured to be dormant normally in a proper environment through an anhydrous system, the activity of the lactobacillus is activated when the lactobacillus is in contact with water, meanwhile, the active effect of oral cavity pathogenic bacteria is inhibited by adding active lactobacillus strains, and the microecological balance of oral cavity flora is regulated, so that the effects of removing halitosis and refreshing breath for a long time are achieved, and the problem that oral cavity care effect is insufficient because the oral cavity product adopting inactivated probiotics cannot effectively inhibit the activity of the oral cavity pathogenic bacteria in the prior art is well solved.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
in a first aspect, the invention provides a lactobacillus anhydrous dental tablet containing living bacteria, which comprises the living lactobacillus, a nutrition additive, an organic acid disintegrating agent, an inorganic alkaline disintegrating agent, an adhesive, a lubricant, a friction agent, a foaming agent, a sweetener and essence, wherein the dosage ratio of the components is as follows: 0.01 to 3 percent of live lactobacillus, 0.2 to 15 percent of nutrition additive, 5 to 22 percent of organic acid disintegrating agent, 10 to 25 percent of inorganic alkaline disintegrating agent, 6 to 40 percent of adhesive, 1.1 to 38 percent of lubricant, 0.6 to 7 percent of friction agent, 0.01 to 1.5 percent of foaming agent, 1.1 to 20 percent of sweetener and 0.01 to 2 percent of essence.
Further, the live lactobacillus is lactobacillus salivarius AP-32 and/or lactobacillus paracasei ET-66.
Wherein, lactobacillus salivarius AP-32 (Lactobacillus salivarius subsp. Salicinius) is preserved in China center for type culture collection (China Center forType Culture Collection, CCTCC) in 4 months and 10 days 2011 (address: university of Wuhan, china, post code: 430072), and the preservation number is CCTCC NO: M2011127; lactobacillus paracasei ET-66 (Lactobacillus paracasei) is preserved in China general microbiological culture Collection center China General Microbiological Culture CollectionCenter, CGMCC (address: north Chen Xilai No.1, 3, postal code: 100101) of the Korean area of Beijing, and has a preservation number of CGMCC No.13514 at day 29 of 2016.
Further, the nutritional additive comprises any one or a combination of at least two of prebiotics, fructooligosaccharides and glucose.
Further, the organic acid disintegrating agent comprises any one or a combination of at least two of citric acid, malic acid, tartaric acid and fumaric acid.
Further, the inorganic alkaline disintegrant is sodium bicarbonate and/or sodium carbonate.
Further, the binder comprises any one or a combination of at least two of microcrystalline cellulose, lactose, polyvinylpyrrolidone and sodium carboxymethyl cellulose.
Further, the lubricant comprises any one or a combination of at least two of polyethylene glycol 4000, polyethylene glycol 6000, magnesium stearate and maltodextrin.
Further, the friction agent comprises any one or a combination of at least two of stone powder, silicon dioxide, calcium hydrophosphate and aluminum hydroxide.
Further, the foaming agent comprises any one or a combination of at least two of sodium lauroyl sarcosinate, sodium dodecyl sulfate, betaine and sodium methyl cocoyl taurate.
Further, the sweetener comprises any one or a combination of at least two of sorbitol, erythritol, xylitol, sucralose and mannitol.
Further, the essence comprises a single essence of any one of fruit, flower, tea, peppermint and candy or a combined essence compounded by at least two kinds of the flavors.
In some technical schemes, the lactobacillus anhydrous dental tablet containing living bacteria comprises the following components in proportion: 0.02 to 3 percent of live lactobacillus, 8.5 percent of nutrition additive, 13 percent of organic acid disintegrating agent, 20 percent of inorganic alkaline disintegrating agent, 29.2 to 32.2 percent of adhesive, 11.5 percent of lubricant, 3 percent of friction agent, 0.5 percent of foaming agent, 10.5 percent of sweetener and 0.8 percent of essence.
In some technical schemes, the lactobacillus anhydrous dental tablet containing living bacteria comprises the following components in proportion: lactobacillus salivarius AP-320-1.5%, lactobacillus paracasei ET-660-1.5%, fructo-oligosaccharide 0.1-5%, glucose 0.1-15%, citric acid 3-12%, malic acid 2-10%, sodium bicarbonate 10-25%, microcrystalline cellulose 5-30%, lactose 1-40%, polyethylene glycol 60001-8%, maltodextrin 0.1-30%, stone powder 0.1-2%, silicon dioxide 0.5-5%, lauroyl sarcosine sodium 0.01-1.5%, sorbitol 1-20%, xylitol 0.1-5%, and essence 0.01-2%.
In a second aspect, the invention provides a preparation method of the lactobacillus anhydrous dental tablet containing living bacteria, which comprises the following steps:
step 1, preparing acid particles: the organic acid disintegrating agent and a part of lubricant are mixed evenly in an equal incremental mode after being sieved by a 40-mesh sieve; then adding a proper amount of 5% PVP solution for mixing, then sieving with a 20-mesh sieve for granulating, and drying at 50 ℃ for 3 hours; then sieving with a 20-mesh sieve to obtain acid particles;
step 2, preparing alkali particles: inorganic alkaline disintegrating agent, friction agent, foaming agent and essence are mixed evenly with a part of adhesive, lubricant, sweetener and nutrition additive through a 40-mesh sieve in an equal incremental mode; then adding a proper amount of 5% PVP solution for mixing, then sieving with a 20-mesh sieve for granulating, and drying at 50 ℃ for 3 hours; then sieving with 20 mesh sieve to obtain alkali particles;
step 3, mixing and tabletting: mixing the acid particles obtained in the step 1 with the alkali particles obtained in the step 2, adding live lactobacillus, and the rest of adhesive, lubricant, sweetener and nutritional additive, uniformly mixing, tabletting and forming under the pressure of 2MPa to obtain the live lactobacillus anhydrous dental tablet finished product.
In a third aspect, the invention also provides application of the lactobacillus anhydrous dental tablet containing living bacteria in preparation of oral cleaning products.
Compared with the prior art, the invention provides the lactobacillus anhydrous dental tablet containing living bacteria, and the preparation method and the application thereof, and has the following beneficial effects:
(1) The lactobacillus anhydrous dental tablet is a solid oral cavity cleaning tablet, is a novel oral cavity cleaning product, has the advantages of convenience in carrying, mild taste, strong breath cleaning capability and the like, and has higher market acceptance and acceptance; and, the solid tablet type can play an important role in survival and activity maintenance of probiotics (living bacteria).
(2) The main raw materials of the lactobacillus anhydrous dental tablet are all carried out while providing survival conditions for probiotics (living bacteria), wherein each nutritional additive provides required nutritional component conditions for normal growth and reproduction of the living lactobacillus, an organic acid disintegrating agent, an inorganic alkaline disintegrating agent, an adhesive and a lubricant are used as basic forming raw materials of the solid tablet, a friction agent and a foaming agent can provide a foaming cleaning function of the toothpaste, and a sweetener and essence are arranged for adding different flavors.
(3) Compared with the common dental film, the lactobacillus anhydrous dental film has the basic functions of cleaning the oral cavity, relieving dental stains, reducing soft dirt, whitening teeth, reducing dental plaque, refreshing breath, refreshing taste, maintaining the health of teeth and periodontal tissues (including gums), keeping the health of the oral cavity and the like, and has the effects of removing halitosis and long-acting fresh breath by inhibiting the activity of pathogenic bacteria of the oral cavity.
Drawings
In order to more clearly illustrate the embodiments of the invention or the technical solutions of the prior art, the drawings which are used in the description of the embodiments or the prior art will be briefly described, it being obvious that the drawings in the description below are only some embodiments of the invention, and that other drawings can be obtained according to these drawings without inventive faculty for a person skilled in the art.
FIG. 1 is a flow chart of a preparation process of the lactobacillus anhydrous dental tablet containing living bacteria.
Detailed Description
The following description of the present invention will be made clearly and fully, and it is apparent that the embodiments described are only some, but not all, of the embodiments of the present invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Lactobacillus salivarius AP-32 (Lactobacillus salivarius subsp. Salicinius) used in the following examples was deposited with China Center for Type Culture Collection (CCTCC) with a deposit number of M2011127; lactobacillus paracasei ET-66 (Lactobacillus paracasei) is preserved in China general microbiological culture Collection center with the preservation number of CGMCC No.13514. The remaining starting materials are also commercially available.
The invention will be described in further detail below by means of detailed embodiments in conjunction with the accompanying drawings.
Example 1
The embodiment provides a lactobacillus anhydrous dental tablet containing living bacteria, which comprises the following components in proportion: lactobacillus salivarius AP-321.5%, lactobacillus paracasei ET-661.5%, fructo-oligosaccharide 0.5%, glucose 8%, citric acid 8%, malic acid 5%, sodium bicarbonate 20%, microcrystalline cellulose 15%, lactose 14.2%, polyethylene glycol 60005%, maltodextrin 6.5%, stone powder 0.5%, silicon dioxide 2.5%, sodium lauroyl sarcosinate 0.5%, sorbitol 10%, xylitol 0.5%, and essence 0.8%.
The preparation method for preparing the viable bacteria-containing lactobacillus anhydrous dental tablets by selecting a semi-dry particle tablet preparation method as tablet forming, referring to figure 1, specifically comprises the following steps:
step 1, preparing acid particles: uniformly mixing citric acid, malic acid and a part of maltodextrin in an equal incremental mode after sieving the citric acid, the malic acid and a part of maltodextrin by a 40-mesh sieve; then adding a proper amount of 5% PVP solution (75% ethanol as a solvent) for mixing, sieving with a 20-mesh sieve for granulating, and drying at 50 ℃ for 3 hours; then sieving with a 20-mesh sieve to obtain acid particles;
step 2, preparing alkali particles: sodium bicarbonate, stone powder, silicon dioxide, sodium lauroyl sarcosinate, essence, lactose, sorbitol, glucose and other part of maltodextrin are sieved by a 40-mesh sieve and uniformly mixed in an equal incremental mode; then adding a proper amount of 5% PVP solution (75% ethanol as a solvent) for mixing, sieving with a 20-mesh sieve for granulating, and drying at 50 ℃ for 3 hours; then sieving with 20 mesh sieve to obtain alkali particles;
step 3, mixing and tabletting: mixing the acid particles obtained in the step 1 with the alkali particles obtained in the step 2, adding lactobacillus salivarius AP-32, lactobacillus paracasei ET-66, microcrystalline cellulose, polyethylene glycol 6000, xylitol and fructo-oligosaccharides, uniformly mixing, tabletting and forming under the pressure of 2MPa, and obtaining the lactobacillus anhydrous dental tablet finished product containing living bacteria.
Example 2
The embodiment provides a lactobacillus anhydrous dental tablet containing living bacteria, which comprises the following components in proportion: lactobacillus salivarius AP-320.5%, lactobacillus paracasei ET-660.5%, fructo-oligosaccharide 0.5%, glucose 8%, citric acid 8%, malic acid 5%, sodium bicarbonate 20%, microcrystalline cellulose 17%, lactose 14.2%, polyethylene glycol 60005%, maltodextrin 6.5%, stone powder 0.5%, silicon dioxide 2.5%, sodium lauroyl sarcosinate 0.5%, sorbitol 10%, xylitol 0.5%, and essence 0.8%.
The preparation method for preparing the viable bacteria-containing lactobacillus anhydrous dental tablets by selecting a semi-dry particle tablet preparation method as tablet forming, referring to figure 1, specifically comprises the following steps:
step 1, preparing acid particles: uniformly mixing citric acid, malic acid and a part of maltodextrin in an equal incremental mode after sieving the citric acid, the malic acid and a part of maltodextrin by a 40-mesh sieve; then adding a proper amount of 5% PVP solution (75% ethanol as a solvent) for mixing, sieving with a 20-mesh sieve for granulating, and drying at 50 ℃ for 3 hours; then sieving with a 20-mesh sieve to obtain acid particles;
step 2, preparing alkali particles: sodium bicarbonate, stone powder, silicon dioxide, sodium lauroyl sarcosinate, essence, lactose, sorbitol, glucose and other part of maltodextrin are sieved by a 40-mesh sieve and uniformly mixed in an equal incremental mode; then adding a proper amount of 5% PVP solution (75% ethanol as a solvent) for mixing, sieving with a 20-mesh sieve for granulating, and drying at 50 ℃ for 3 hours; then sieving with 20 mesh sieve to obtain alkali particles;
step 3, mixing and tabletting: mixing the acid particles obtained in the step 1 with the alkali particles obtained in the step 2, adding lactobacillus salivarius AP-32, lactobacillus paracasei ET-66, microcrystalline cellulose, polyethylene glycol 6000, xylitol and fructo-oligosaccharides, uniformly mixing, tabletting and forming under the pressure of 2MPa, and obtaining the lactobacillus anhydrous dental tablet finished product containing living bacteria.
Example 3
The embodiment provides a lactobacillus anhydrous dental tablet containing living bacteria, which comprises the following components in proportion: lactobacillus paracasei ET-660.5%, fructo-oligosaccharide 0.5%, glucose 8%, citric acid 8%, malic acid 5%, sodium bicarbonate 20%, microcrystalline cellulose 17%, lactose 14.7%, polyethylene glycol 60005%, maltodextrin 6.5%, stone dust 0.5%, silicon dioxide 2.5%, sodium lauroyl sarcosinate 0.5%, sorbitol 10%, xylitol 0.5% and essence 0.8%.
The preparation method for preparing the viable bacteria-containing lactobacillus anhydrous dental tablets by selecting a semi-dry particle tablet preparation method as tablet forming, referring to figure 1, specifically comprises the following steps:
step 1, preparing acid particles: uniformly mixing citric acid, malic acid and a part of maltodextrin in an equal incremental mode after sieving the citric acid, the malic acid and a part of maltodextrin by a 40-mesh sieve; then adding a proper amount of 5% PVP solution (75% ethanol as a solvent) for mixing, sieving with a 20-mesh sieve for granulating, and drying at 50 ℃ for 3 hours; then sieving with a 20-mesh sieve to obtain acid particles;
step 2, preparing alkali particles: sodium bicarbonate, stone powder, silicon dioxide, sodium lauroyl sarcosinate, essence, lactose, sorbitol, glucose and other part of maltodextrin are sieved by a 40-mesh sieve and uniformly mixed in an equal incremental mode; then adding a proper amount of 5% PVP solution (75% ethanol as a solvent) for mixing, sieving with a 20-mesh sieve for granulating, and drying at 50 ℃ for 3 hours; then sieving with 20 mesh sieve to obtain alkali particles;
step 3, mixing and tabletting: mixing the acid particles obtained in the step 1 with the alkali particles obtained in the step 2, adding lactobacillus paracasei ET-66, microcrystalline cellulose, polyethylene glycol 6000, xylitol and fructo-oligosaccharide, uniformly mixing, tabletting and forming under the pressure of 2MPa, and obtaining the lactobacillus anhydrous dental tablet finished product containing living bacteria.
Example 4
The embodiment provides a lactobacillus anhydrous dental tablet containing living bacteria, which comprises the following components in proportion: lactobacillus salivarius AP-320.5%, fructo-oligosaccharide 0.5%, glucose 8%, citric acid 8%, malic acid 5%, sodium bicarbonate 20%, microcrystalline cellulose 17%, lactose 14.7%, polyethylene glycol 60005%, maltodextrin 6.5%, stone dust 0.5%, silicon dioxide 2.5%, sodium lauroyl sarcosinate 0.5%, sorbitol 10%, xylitol 0.5%, and essence 0.8%.
The preparation method for preparing the viable bacteria-containing lactobacillus anhydrous dental tablets by selecting a semi-dry particle tablet preparation method as tablet forming, referring to figure 1, specifically comprises the following steps:
step 1, preparing acid particles: uniformly mixing citric acid, malic acid and a part of maltodextrin in an equal incremental mode after sieving the citric acid, the malic acid and a part of maltodextrin by a 40-mesh sieve; then adding a proper amount of 5% PVP solution (75% ethanol as a solvent) for mixing, sieving with a 20-mesh sieve for granulating, and drying at 50 ℃ for 3 hours; then sieving with a 20-mesh sieve to obtain acid particles;
step 2, preparing alkali particles: sodium bicarbonate, stone powder, silicon dioxide, sodium lauroyl sarcosinate, essence, lactose, sorbitol, glucose and other part of maltodextrin are sieved by a 40-mesh sieve and uniformly mixed in an equal incremental mode; then adding a proper amount of 5% PVP solution (75% ethanol as a solvent) for mixing, sieving with a 20-mesh sieve for granulating, and drying at 50 ℃ for 3 hours; then sieving with 20 mesh sieve to obtain alkali particles;
step 3, mixing and tabletting: mixing the acid particles obtained in the step 1 with the alkali particles obtained in the step 2, adding lactobacillus salivarius AP-32, microcrystalline cellulose, polyethylene glycol 6000, xylitol and fructo-oligosaccharide, uniformly mixing, tabletting and forming under the pressure of 2MPa, and obtaining the lactobacillus anhydrous dental tablet finished product containing living bacteria.
Example 5
The embodiment provides a lactobacillus anhydrous dental tablet containing living bacteria, which comprises the following components in proportion: lactobacillus salivarius AP-320.1%, lactobacillus paracasei ET-660.1%, fructo-oligosaccharide 0.5%, glucose 8%, citric acid 8%, malic acid 5%, sodium bicarbonate 20%, microcrystalline cellulose 17%, lactose 15.18%, polyethylene glycol 60005%, maltodextrin 6.5%, stone powder 0.5%, silicon dioxide 2.5%, sodium lauroyl sarcosinate 0.5%, sorbitol 10%, xylitol 0.5%, and essence 0.8%.
The preparation method for preparing the viable bacteria-containing lactobacillus anhydrous dental tablets by selecting a semi-dry particle tablet preparation method as tablet forming, referring to figure 1, specifically comprises the following steps:
step 1, preparing acid particles: uniformly mixing citric acid, malic acid and a part of maltodextrin in an equal incremental mode after sieving the citric acid, the malic acid and a part of maltodextrin by a 40-mesh sieve; then adding a proper amount of 5% PVP solution (75% ethanol as a solvent) for mixing, sieving with a 20-mesh sieve for granulating, and drying at 50 ℃ for 3 hours; then sieving with a 20-mesh sieve to obtain acid particles;
step 2, preparing alkali particles: sodium bicarbonate, stone powder, silicon dioxide, sodium lauroyl sarcosinate, essence, lactose, sorbitol, glucose and other part of maltodextrin are sieved by a 40-mesh sieve and uniformly mixed in an equal incremental mode; then adding a proper amount of 5% PVP solution (75% ethanol as a solvent) for mixing, sieving with a 20-mesh sieve for granulating, and drying at 50 ℃ for 3 hours; then sieving with 20 mesh sieve to obtain alkali particles;
step 3, mixing and tabletting: mixing the acid particles obtained in the step 1 with the alkali particles obtained in the step 2, adding lactobacillus salivarius AP-32, lactobacillus paracasei ET-66, microcrystalline cellulose, polyethylene glycol 6000, xylitol and fructo-oligosaccharides, uniformly mixing, tabletting and forming under the pressure of 2MPa, and obtaining the lactobacillus anhydrous dental tablet finished product containing living bacteria.
Comparative example 1
The comparative example provides an anhydrous dental tablet, which comprises the following components in proportion: 0.5% of fructo-oligosaccharide, 8% of glucose, 8% of citric acid, 5% of malic acid, 20% of sodium bicarbonate, 17% of microcrystalline cellulose, 15.2% of lactose, 60005% of polyethylene glycol, 6.5% of maltodextrin, 0.5% of stone powder, 2.5% of silicon dioxide, 0.5% of sodium lauroyl sarcosinate, 10% of sorbitol, 0.5% of xylitol and 0.8% of essence.
The preparation method for selecting the semi-dry particle tabletting method as the tabletting forming method comprises the following steps:
step 1, preparing acid particles: uniformly mixing citric acid, malic acid and a part of maltodextrin in an equal incremental mode after sieving the citric acid, the malic acid and a part of maltodextrin by a 40-mesh sieve; then adding a proper amount of 5% PVP solution (75% ethanol as a solvent) for mixing, sieving with a 20-mesh sieve for granulating, and drying at 50 ℃ for 3 hours; then sieving with a 20-mesh sieve to obtain acid particles;
step 2, preparing alkali particles: sodium bicarbonate, stone powder, silicon dioxide, sodium lauroyl sarcosinate, essence, lactose, sorbitol, glucose and other part of maltodextrin are sieved by a 40-mesh sieve and uniformly mixed in an equal incremental mode; then adding a proper amount of 5% PVP solution (75% ethanol as a solvent) for mixing, sieving with a 20-mesh sieve for granulating, and drying at 50 ℃ for 3 hours; then sieving with 20 mesh sieve to obtain alkali particles;
step 3, mixing and tabletting: mixing the acid particles obtained in the step 1 with the alkali particles obtained in the step 2, adding microcrystalline cellulose, polyethylene glycol 6000, xylitol and fructo-oligosaccharide, uniformly mixing, tabletting and forming under the pressure of 2MPa, and obtaining the anhydrous dental tablet finished product.
1. Method for detecting viable bacteria number of lactobacillus
Taking the live lactobacillus anhydrous dental tablet product obtained in example 3, and referring to GB 4789.35-2016 test method to test total lactobacillus, wherein the test result is 5.1X10 6 CFU/g。
2. Evaluation of breath freshening Effect
1. Experimental materials the test samples were the finished products prepared in examples 1 to 5 and comparative example 1.
2. The experimental method comprises the following steps: 120 patients with halitosis or bad breath at age of 25-50 years old are randomly divided into 6 groups of 20 persons, each group is respectively subjected to oral care by using a corresponding test sample, and the test samples are used for oral care or tooth brushing in the morning and evening every day. For a period of 1 month, its effect on bad breath or oral malodour symptoms was observed.
3. Evaluation criteria: the evaluation of the therapeutic effect is divided into 4 types of obvious effect, effective, light effect and ineffective. The obvious effect means that the patient continuously uses the test sample for 1 month, the symptoms such as halitosis, bad breath and the like disappear, and the teeth are firm in texture; effectively means that the symptoms such as halitosis, bad breath and the like are greatly improved after the patient continuously uses the test sample for 1 month; the light effect means that the symptoms of bad breath, bad breath and the like are relieved but still exist occasionally after the patient uses the test sample for 1 month; the ineffectiveness means that the patient has no improvement on bad breath, bad breath and the like after continuously using the test sample for 1 month.
4. Evaluation of Effect
Table 1 evaluation results
As can be seen from the table 1, compared with the product provided by the comparative example, the lactobacillus anhydrous dental tablet containing living bacteria provided by the invention has a certain degree of alleviation effect on symptoms such as halitosis and bad breath, and the effective rate can reach 60% or more; with the increase of the use amount of the live lactobacillus, the breath freshening ratio is increased; the subjects show that after oral care is carried out by using the lactobacillus anhydrous dental tablet containing the living bacteria, breath is fresh, peculiar smell disappears and no adverse reaction exists, and the lactobacillus anhydrous dental tablet containing the living bacteria provided by the invention is safe and effective, can inhibit the activity of pathogenic bacteria in the oral cavity, and regulate the microecological balance of oral flora so as to achieve the effects of removing halitosis and refreshing the breath for a long time.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, alternatives, and improvements that fall within the spirit and scope of the invention.
Furthermore, it should be understood that although the present disclosure describes embodiments, not every embodiment is provided with a separate embodiment, and that this description is provided for clarity only, and that the disclosure is not limited to the embodiments described in detail below, and that the embodiments described in the examples may be combined as appropriate to form other embodiments that will be apparent to those skilled in the art.
Claims (10)
1. The lactobacillus anhydrous dental tablet containing living bacteria is characterized by comprising living lactobacillus, a nutritional additive, an organic acid disintegrating agent, an inorganic alkaline disintegrating agent, an adhesive, a lubricant, a friction agent, a foaming agent, a sweetener and essence, wherein the dosage ratio of the components is as follows: 0.01 to 3 percent of live lactobacillus, 0.2 to 15 percent of nutrition additive, 5 to 22 percent of organic acid disintegrating agent, 10 to 25 percent of inorganic alkaline disintegrating agent, 6 to 40 percent of adhesive, 1.1 to 38 percent of lubricant, 0.6 to 7 percent of friction agent, 0.01 to 1.5 percent of foaming agent, 1.1 to 20 percent of sweetener and 0.01 to 2 percent of essence.
2. The live bacteria-containing lactobacillus anhydrous dental tablet according to claim 1, wherein: the live lactobacillus is lactobacillus salivarius AP-32 and/or lactobacillus paracasei ET-66.
3. The live bacteria-containing lactobacillus anhydrous dental tablet according to claim 1, wherein: the nutritional additive comprises any one or a combination of at least two of prebiotics, fructooligosaccharides and glucose.
4. The live bacteria-containing lactobacillus anhydrous dental tablet according to claim 1, wherein: the organic acid disintegrating agent comprises any one or a combination of at least two of citric acid, malic acid, tartaric acid and fumaric acid; the inorganic alkaline disintegrating agent is sodium bicarbonate and/or sodium carbonate.
5. The live bacteria-containing lactobacillus anhydrous dental tablet according to claim 1, wherein: the binder comprises any one or a combination of at least two of microcrystalline cellulose, lactose, polyvinylpyrrolidone and sodium carboxymethyl cellulose.
6. The live bacteria-containing lactobacillus anhydrous dental tablet according to claim 1, wherein: the lubricant comprises any one or a combination of at least two of polyethylene glycol 4000, polyethylene glycol 6000, magnesium stearate and maltodextrin.
7. The live bacteria-containing lactobacillus anhydrous dental tablet according to claim 1, wherein: the friction agent comprises any one or a combination of at least two of stone powder, silicon dioxide, calcium hydrophosphate and aluminum hydroxide; the foaming agent comprises any one or a combination of at least two of sodium lauroyl sarcosinate, sodium dodecyl sulfate, betaine and sodium methyl cocoyl taurate.
8. The live bacteria-containing lactobacillus anhydrous dental tablet according to claim 1, wherein: the sweetener comprises any one or a combination of at least two of sorbitol, erythritol, xylitol, sucralose and mannitol; the essence comprises a single essence with any one of fruit fragrance, flower fragrance, tea fragrance, peppermint fragrance and candy fragrance or a combined essence compounded by at least two fragrance types.
9. The method for producing a live bacterium-containing lactic acid bacterium anhydrous dental film according to any one of claims 1 to 8, comprising the steps of:
step 1, preparing acid particles: the organic acid disintegrating agent and a part of lubricant are mixed evenly in an equal incremental mode after being sieved by a 40-mesh sieve; then adding a proper amount of 5% PVP solution for mixing, then sieving with a 20-mesh sieve for granulating, and drying at 50 ℃ for 3 hours; then sieving with a 20-mesh sieve to obtain acid particles;
step 2, preparing alkali particles: inorganic alkaline disintegrating agent, friction agent, foaming agent and essence are mixed evenly with a part of adhesive, lubricant, sweetener and nutrition additive through a 40-mesh sieve in an equal incremental mode; then adding a proper amount of 5% PVP solution for mixing, then sieving with a 20-mesh sieve for granulating, and drying at 50 ℃ for 3 hours; then sieving with 20 mesh sieve to obtain alkali particles;
step 3, mixing and tabletting: mixing the acid particles obtained in the step 1 with the alkali particles obtained in the step 2, adding live lactobacillus, and the rest of adhesive, lubricant, sweetener and nutritional additive, uniformly mixing, tabletting and forming under the pressure of 2MPa to obtain the live lactobacillus anhydrous dental tablet finished product.
10. Use of a live bacteria-containing lactobacillus anhydrous dental tablet according to any of claims 1 to 8 in the preparation of an oral cleaning product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310759117.7A CN117100675A (en) | 2023-06-26 | 2023-06-26 | Lactobacillus anhydrous dental tablet containing living bacteria and preparation method and application thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1179972A (en) * | 1997-09-29 | 1998-04-29 | 杨成玉 | Multifunctional effervescent for cleaning mouth |
| CN105685342A (en) * | 2016-02-18 | 2016-06-22 | 江苏微康生物科技有限公司 | Probiotic buccal tablet and preparation method thereof |
| CN107206031A (en) * | 2015-07-07 | 2017-09-26 | 东亚药品工业株式会社 | Intraorally rapidly disintegrable tablet containing bacterium |
| CN107308102A (en) * | 2017-07-10 | 2017-11-03 | 云南白药集团股份有限公司 | A kind of solid type probiotics mouthwash and preparation method thereof and application method |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1179972A (en) * | 1997-09-29 | 1998-04-29 | 杨成玉 | Multifunctional effervescent for cleaning mouth |
| CN107206031A (en) * | 2015-07-07 | 2017-09-26 | 东亚药品工业株式会社 | Intraorally rapidly disintegrable tablet containing bacterium |
| CN105685342A (en) * | 2016-02-18 | 2016-06-22 | 江苏微康生物科技有限公司 | Probiotic buccal tablet and preparation method thereof |
| CN107308102A (en) * | 2017-07-10 | 2017-11-03 | 云南白药集团股份有限公司 | A kind of solid type probiotics mouthwash and preparation method thereof and application method |
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