CN1179972A

CN1179972A - Multifunctional effervescent for cleaning mouth

Info

Publication number: CN1179972A
Application number: CN 97116935
Authority: CN
Inventors: 李仁俊; 杨成玉
Original assignee: Individual
Current assignee: Individual
Priority date: 1997-09-29
Filing date: 1997-09-29
Publication date: 1998-04-29

Abstract

The multifunctional effervescent tablet for cleaning mouth cavity is prepared by using effective component extract of Chinese herbal medicine as medicinal component and its carrier, adding effervescent disintegrant, diluent, surfactant (foaming agent), germicide, stabilizing and rubbing agent and binder and making them pass through a certain preparation process. Said invention is reasonable in prescription composition, stable in performance, obvious in therapeutic effect, possesses low surface tension, proper pH value and good detersive power, can be used for cleaning mouth cavity and preventing and curing oral diseases, such as dental caries, gingivitis, periodontitis, oral mucosa disease and laryngopharyngitis, so that it is a safe and effective health-care product which is easy to carry about, and can be used for preventing and curing oral diseases.

Description

Multifunctional effervescent for cleaning mouth

The present invention relates to a kind of oral cavity and denture cleanser, particularly a kind of multifunctional effervescent for cleaning mouth, promptly the multipotency mouth is clean.

In actual life, before sleeping, people all brush teeth after meal to remove tooth and oral cavity dirty, brush teeth and all use toothpaste, existing toothpaste, with regard to its function, the branch that ordinary toothpaste and medicated toothpaste are arranged, use the medicated toothpaste decapacitation of brushing teeth to finish and use outside the removing tooth and oral cavity incrustation sediment function that ordinary toothpaste brushes teeth, because wherein contained active ingredient acts on gingiva and oral cavity in brush teeth removing tooth and oral cavity dirty process, tooth and oral disease there is certain therapeutical effect, yet existing toothpaste, as the term suggests all be paste, packing, carry inconvenience, and with after all also must gargle by clear water, owing in use must match with toothbrush, thereby not only use inconvenience, and in use, toothbrush is to Buccodental, gingivas etc. also have damage, particularly for the patient who suffers from oral inflammation and odontopathy, the use of toothbrush is inconvenience especially just.And the collutory that development in recent years is got up, tasty and refreshing, sterilization though can overcome the brush teeth deficiency of boil on the nape opposite the mouth chamber tooth, gingiva damage of existing toothpaste, seems unable to do what one wishes with it to cleaning teeth, to a certain extent, does not replace toothpaste to brush teeth.

Existing denture cleanser owing to contain harmful strong Fungicidal substance more, thereby with after all want clear water thoroughly to clean, definitely can not be with medicine to enter the mouth.

The objective of the invention is to overcome above-mentioned the deficiencies in the prior art, and provide a kind of pack easy to carry and with after need not clear water gargle, without toothbrush and can play toothbrushing effect and pharynx-clearing throat-benefiting, to oral inflammation and odontopathy have better prevention effect, can also be as the multifunctional effervescent for cleaning mouth of denture cleanser and collutory.

Purpose of the present invention can realize by such technical scheme: this packing easy to carry and with after need not clear water gargle, without toothbrush and can play toothbrushing effect and pharynx-clearing throat-benefiting, to oral inflammation and odontopathy have better prevention effect, can also be as the multifunctional effervescent for cleaning mouth of denture cleanser and collutory, it is that effective component extracts with Chinese herbal medicine such as Flos Lonicerae, Radix Scutellariae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae, Radix Ophiopogonis is an active ingredient; With the aluminium hydroxide is active ingredient carrier and lubricant; With tartaric acid and sodium bicarbonate is gas-producing disintegrant; With mannitol is diluent; With the sodium lauryl sulphate is surfactant (foaming agent); With the Borax is antibacterial; Be stable and abrasivus with calcium sulfate; With the polyvinylpyrrolidone for binding agent compatibility preparation, can produce a large amount of bubbles when sucking, with motion of air bubbles friction tooth the soft dirt on tooth top is come off by abrasivus from the surface, and short its suspended dispersed, prevent redeposition, by making the dirt moistening after the surfactant activation wherein, and with dirt generation chemical action, destroy the adhesion of dirt gradually in the oral cavity, dirt is become be easy to dissolved substances and remove, play the effect in cleaning teeth and oral cavity, and active ingredient wherein has very strong inhibitory action to bacterial plaque and some oral cavity pathogens, by its dissolving and by buccal absorption, reach sterilization, antimicrobial purpose.

Above-mentioned multifunctional effervescent for cleaning mouth, its each constituent content can be by weight percentage:

Active ingredient 4～10

Aluminium hydroxide 2～4

Tartaric acid 12～19

Sodium bicarbonate 24～30

Mannitol 11～18

Sodium lauryl sulphate 1～6

Borax 2～8

Calcium sulfate 3～6

Polyvinylpyrrolidone 1～6

This multifunctional effervescent for cleaning mouth provided by the present invention is sucked or chews in the oral cavity 4～5 minutes promptly effectively, and clear water is gargled and do not gargle all right behind the dirty that spues.

This multifunctional effervescent for cleaning mouth provided by the present invention, the test of pesticide effectiveness:

1, staphylococcus aureus, Staphylococcus albus, beta hemolytic streptococcus, viridans streptococci, staphylococcus epidermidis, melanin anaerobic bacillus(cillus anaerobicus), Gram-negative streptococcus, Candida albicans and escherichia coli etc. all there is significant inhibitory effect.

2, has good antiinflammatory action.

Toxicological test:

1, acute toxicity test in mice: do not see any toxic reaction.

2, rabbit skin irritant test: the skin morphological examination does not have pathology and changes.

3, rabbit mucomembranous irritant test: nonirritant, the not swollen formation of water breakthrough.

4, guinea pig skin hypersensitive test: skin is not had sensitization.

5, Cavia porcellus long term toxicity test: state, body weight, blood and serum biochemistry are learned and are checked that organ coefficient and histopathologic examination there is no notable difference, show this product safety non-toxic.

Clinical observation:

1, clean the teeth, deodorization, cleaning oral cavity effect such as tasty and refreshing be better than commercially available medicated toothpaste.

2,500 many cases observed result on probation is as follows in this year:

(1), the diseases of oral mucosa total effective rate is reached 94.8% (wherein: actute infection stomatitis effective percentage reaches 91.2%, and recurrent oral ulcer effective percentage reaches 98.5%, and acute multiple gingival abscess effective percentage reaches 94.6%).

(2), the gingivitis effective percentage is reached 83.5%.

(3), the periodontitis effective percentage is reached 81.2%.

(4), the effective percentage to periodontal abscess, gingival hemorrhage, halitosis reaches 85.6%.

(5), the dental caries suppression ratio is reached about 35%.Carry out 1 year trying out through nearly 300 students, the dental caries incidence rate descends 40～76% as a result.

This multifunctional effervescent for cleaning mouth provided by the present invention, compare with toothpaste:

1, use, easy to carry;

2, exempt from toothbrush, exempt from water, whenever and wherever possible cleaning teeth;

3, avoid tooth because of loss that excessive friction produced;

4, contain that medicine is many, dispersion force is wide, action time is longer more than one times than toothpaste, so clean the teeth and prevent that the odontopathy effect is higher than toothpaste;

5, go the effect of halitosis rapider and lasting than toothpaste;

6, can swallow clothes, be applicable to very much the crowd that inconvenience is brushed teeth.

Compare with collutory:

1, the foaming decontamination is big;

2, adsorption is big;

3, dissolving, decomposition, neutralization are strong;

4, sterilization, bacteriostasis are big;

5, packing, transportation formality simplification, convenient.

6, removal halitosis effect is remarkable.

Compare with commercially available false-tooth cleaning plate: water consumption is little, soak time is short, cleaning effect is good and with after need not flushing with clean water, can keep fragrant.

As seen from the above, this multifunctional effervescent for cleaning mouth provided by the present invention, each component compatibility of writing out a prescription is precise and appropriate, stable performance, remarkably productive, confirm the effect that has cleaning oral cavity and prevent and treat dental caries, gingivitis, periodontitis, diseases of oral mucosa and pharyngolaryngitis through toxicity, pharmacological testing and clinical verification; Has low surface tension and suitable pH value, good dirt-removing power is arranged, thereby it is the safe and effective new medicine that can prevent and treat oral disease, also be portable, clean the teeth, tasty and refreshing desirable health care daily necessities.

The present invention is described in further detail below in conjunction with embodiment:

Example: the embodiment of the invention provide a kind of pack easy to carry and with after need not clear water gargle, without toothbrush and can play toothbrushing effect and pharynx-clearing throat-benefiting, to oral inflammation and odontopathy have better prevention effect, can also be as the multifunctional effervescent for cleaning mouth of denture cleanser and collutory, be that the effective component extracts with Chinese herbal medicine such as Flos Lonicerae, Radix Scutellariae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae, Radix Ophiopogonis is an active ingredient; With the aluminium hydroxide is active ingredient carrier and lubricant; With tartaric acid and sodium bicarbonate is gas-producing disintegrant; With the sodium carbonate is the effervescent disintegrate promoter of tartaric acid and sodium bicarbonate; With mannitol is diluent; With the sodium lauryl sulphate is surfactant (foaming agent); With the Borax is antibacterial; Be stable and abrasivus with calcium sulfate; With the polyvinylpyrrolidone is binding agent; With the lactose is filler; With the sodium citrate is cosolvent; With the sodium benzoate is antiseptic; Add sweeting agent, fragrance fixing agent compatibility preparation again, each constituent content can be by weight percentage:

Active ingredient 4～8

Aluminium hydroxide 2～3

Tartaric acid 12～16

Sodium bicarbonate 20～26

Sodium carbonate 1～3

Mannitol 5～10

Sodium lauryl sulphate 1～5

Borax 2～5

Calcium sulfate 2～4

Polyvinylpyrrolidone 4～6

Lactose 3～6

Sodium citrate 5～10

Sodium benzoate 2～5

Sweeting agent 0.5～1

The multifunctional effervescent for cleaning mouth that fragrance fixing agent 0.5～2 is this is preparation like this:

1, the each component material is weighed by prescription, pulverize, cross dusting cover then;

2, be that grouping all mixes with the each component material except that active ingredient by acid, alkali two;

3, be that the active ingredient of 1.25～1.35g/ml extracts extractum and divides two groups to sneak into bronsted lowry acids and bases bronsted lowry respectively be in the material mixture with density, all mix oven dry again;

4, binding agent is dissolved in the dehydrated alcohol;

5, will sneak into acid, the alkali that active ingredient extracts extractum is the material mixture joins in the dehydrated alcohol that is dissolved with binding agent, all mixes, oven dry;

6, cross dusting cover;

7, add lubricant, flavoring agent, all mixed, tabletting promptly makes multifunctional effervescent for cleaning mouth of the present invention.

Claims

1, a kind of multifunctional effervescent for cleaning mouth is characterized in that: it is that effective component extracts with Chinese herbal medicine such as Flos Lonicerae, Radix Scutellariae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae, Radix Ophiopogonis is an active ingredient; With the aluminium hydroxide is active ingredient carrier and lubricant; With tartaric acid and sodium bicarbonate is gas-producing disintegrant; With mannitol is diluent; With the sodium lauryl sulphate is surfactant (foaming agent); With the Borax is antibacterial; Be stable and abrasivus with calcium sulfate; With the polyvinylpyrrolidone for binding agent compatibility preparation.

2, multifunctional effervescent for cleaning mouth according to claim 1 is characterized in that: its each constituent content can be by weight percentage:

Active ingredient 4～10

Aluminium hydroxide 2～4

Tartaric acid 12～19

Sodium bicarbonate 24～30

Mannitol 11～18

Sodium lauryl sulphate 1～6

Borax 2～8

Calcium sulfate 3～6

Polyvinylpyrrolidone 1～6.

3, multifunctional effervescent for cleaning mouth according to claim 1 and 2 is characterized in that: it also contains the effervescent disintegrate promoter of tartaric acid and sodium bicarbonate---sodium carbonate, filler---lactose, cosolvent---sodium citrate, sterilization antiseptic---sodium benzoate, sweeting agent and fragrance fixing agent.

4, multifunctional effervescent for cleaning mouth according to claim 3 is characterized in that: its each constituent content can be by weight percentage:

Active ingredient 4～8

Aluminium hydroxide 2～3

Tartaric acid 12～16

Sodium bicarbonate 20～26

Sodium carbonate 1～3

Mannitol 5～10

Sodium lauryl sulphate 1～5

Borax 2～5

Calcium sulfate 2～4 polyvinylpyrrolidones 4～6

Lactose 3～6

Sodium citrate 5～10

Sodium benzoate 2～5

Sweeting agent 0.5～1

Fragrance fixing agent 0.5～2.