CN103356811B - Chewable tables for oral cavities as well as preparation method and application thereof - Google Patents
Chewable tables for oral cavities as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses chewable tables for oral cavities as well as a preparation method and an application thereof. Each chewable table comprises 0.5%-20% of drynaria total flavonoids, 5-50% of tea polyphenol and the balance of pharmaceutically acceptable carrier in percentage by mass. The preparation method of the chewable tables comprises the following steps of: crushing, sieving, mixing, pelleting, drying, pressing and packaging the 0.5%-20% of drynaria total flavonoids, the 5-50% of tea polyphenol and the balance of filler, corrigent, wetting agent, binding agent and lubricating agent; and as for the application, the chewable tables for oral cavity nursing are put in a mouth and chewed, and then the mouth is rinsed with clear water. As the tea polyphenol has good health care and treatment effect on oral cavity inflammation and oropharynx inflammation and the drynaria total flavonoids has a promotion effect on the repair, regeneration and rebuilding of periodontium, the chewable tables can be used for promoting the health of the oral cavities by adding the drynaria total flavonoids and the tea polyphenol.
Description
Technical field
The present invention relates to oral cavity chewable tablet, refer to a kind of oral cavity chewable tablet and preparation method thereof and application particularly.
Background technology
Along with the raising of people's living standard, improve constantly pursuit that is beautiful and healthy living, oral hygiene has become one of focus of modern's concern.Modal in oral disease is dental caries and periodontal disease, and China per capita average caries prevalence rate is 70%, and periodontal disease prevalence is up to more than 90%.One of World Health Organization's three large diseases dental caries being classified as mankind's keypoint control, by one of the health of periodontal tissue 10 standards being classified as human health.Oral health also becomes the index weighing people's living standard, and oral health articles for use have become people's daily necessities.
Dental care product main on current market is toothpaste and toothbrush, and also have dental floss in addition, China has been manufacturing country and the country of consumption of toothpaste maximum in the world and toothbrush, and toothbrush and the toothpaste of dissimilar and function have met the daily demand of people substantially.But along with the progress in epoch, the rhythm of life of people is more and more faster, common toothpaste and toothbrush are not in step with the times, brush teeth for crowds such as many business people, long-time outdoor activities personages after the meal, become a kind of burden, the new product such as collutory and chewing gum arises at the historic moment subsequently.Collutory has become a kind of fashion abroad, plays the part of more and more important role in daily life, and chewing gum also day by day gos deep into the life of people.But this two series products, especially collutory also rests in high-end crowd and consumes, be mainly foreign brand name, as Lee's stirling, Colgate-Palmolive, Crest, Ou Le B etc., price is generally higher, be difficult to the demand meeting ordinary people, in addition, collutory is liquid form article, and packaging volume is large, carry inconvenience, often limit when vehicles such as airplane and carry; When not dividing Sheng instrument, also inconvenient many people use, and collutory General Requirements continues, containing time a few minutes, to be easy to cause wrongly taking of collutory after gargling.Although chewing gum is easy to carry, easy to use, after using, remaining chewing gum not easily processes, and affects environment.In addition, the fluorochemical that current oral care product adopts mostly, as sodium fluoride, in order to caries prevention; Adopt antibiotic, as nitrofural, or cationic surfactant, as pyrrole oronain, in order to antibacterial; Peroxide, as hydrogen peroxide, in order to bleaching teeth; These chemical substances also exist side effect, affect the untoward reaction of oral cavity normal microenvironment, also do not meet modern and pursue nature, the consumption concept of natural environmental-protective, and natural product substitutes the requirement that synthesis compound has been the epoch.
Therefore, need a kind of new oral care product badly, both there is the function of good oral cavity health, as whitening, preventing decayed tooth, antiinflammatory; Be made up of natural component, no side effects; Easy to use, easy to carry; Environmental friendliness, cleaning is convenient; Reasonable price.
Summary of the invention
The object of the invention is to the weak point overcoming above-mentioned existing background technology, and provide a kind of mouth care chewable tablet and preparation method thereof and application, to meet good oral cavity health object.
A kind of mouth care chewable tablet, containing mass fraction in its every tablet is the Process of Total Flavonoids in Drynaria Fortunei of 0.5% ~ 20%, and mass fraction is the tea polyphenols of 5% ~ 50%, and the pharmaceutically acceptable carrier of surplus.
The good technical scheme of the present invention: a kind of mouth care chewable tablet, containing mass fraction in its every tablet is the Process of Total Flavonoids in Drynaria Fortunei of 0.5% ~ 10%, and mass fraction is the tea polyphenols of 10% ~ 30%, and the pharmaceutically acceptable carrier of surplus.
The better technical scheme of the present invention is: containing mass fraction in every tablet is the Process of Total Flavonoids in Drynaria Fortunei of 1% ~ 5%, and mass fraction is the tea polyphenols of 15% ~ 25%, and the pharmaceutically acceptable carrier of surplus.
The technical scheme that the present invention is best: containing mass fraction in every tablet is the Process of Total Flavonoids in Drynaria Fortunei of 2%, mass fraction is tea polyphenols and the pharmaceutically acceptable mixed carrier of surplus of 20%, described mixed carrier comprises the sucrose that mass fraction is 15%, mass fraction is the mannitol of 5%, mass fraction is the sorbitol of 15%, mass fraction is the xylitol of 12%, mass fraction is the glucose of 3%, mass fraction is the citric acid of 5%, mass fraction is the saccharin sodium of 5%, mass fraction is the sodium cocoyl glycinate of 3%, mass fraction is the starch slurry of 6%, mass fraction is the carboxymethyl cellulose of 6%, mass fraction is the magnesium stearate of 3%.
After using above-mentioned best technical scheme gained chewable tablet, implication is more pure and fresh, halitosis phenomenon improves, plaque index and gingival index obviously reduce, use and can alleviate oral inflammation in more than one week, gingival hemorrhage phenomenon reduces, use 1 ~ 3 month oral inflammation and oropharynx inflammation to be clearly better, use half a year, above Periodontal Status also improved.
For preparation chewable tablet of the present invention, except Process of Total Flavonoids in Drynaria Fortunei and tea polyphenols, as long as no special untoward reaction, surplus is pharmaceutically acceptable carrier, the additive that can use for conventional tablet, example comprises filler, disintegrating agent, correctives, wetting agent, binding agent and the lubricant that pharmaceutics allows.Wherein, filler can be one of microcrystalline Cellulose, starch, sucrose, dextrin, lactose, pregelatinized Starch, mannitol, sorbitol or its combination in any, be mainly used in the weight or volume increasing tablet, reduce the dose deviations of main constituent, improve the compact property of tablet; Disintegrating agent can be starch, carboxymethyl starch sodium, low-substituted hydroxypropyl methylcellulose, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose or effervescent, wherein effervescent comprises sour agent and alkaline agent, wherein sour agent comprises one of citric acid, tartaric acid, fumaric acid or its combination in any, alkaline agent comprises one of sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate or its combination in any, and the pH of the dissolved aqueous solution of described effervescent is 8-10; Correctives can be one of xylitol, mannitol, sucrose, glucose, citric acid, aspartame, stevioside, saccharin sodium, Mentholum, Oleum menthae or its combination in any, is mainly used in improving taste; Wetting agent can be one of sodium lauryl sulphate, sodium cocoyl glycinate, alkyl amido betaine, sodium cocoyl glutamate or its combination in any, is mainly used in the surface tension reducing main component and dental surface, is conducive to main constituent and teeth contact; Binding agent can be one of starch slurry, polyvinylpyrrolidone, hypromellose, carboxymethyl cellulose or its combination in any, is mainly used in improving the viscosity between granule, is conducive to granule and is formed; Lubricant can be one of magnesium stearate, micropowder silica gel, Pulvis Talci, hydrogenated vegetable oil, Polyethylene Glycol, sodium lauryl sulphate or its combination in any, be mainly used in reducing the frictional force in tabletting and push jack process between tablet and punch die, ensure that the stress distribution of tabletting is even, prevent sliver.
Wherein, described Process of Total Flavonoids in Drynaria Fortunei is Rhizoma Drynariae extract, and described tea polyphenols is green tea extract, and Process of Total Flavonoids in Drynaria Fortunei and tea polyphenols are buied by market.
The preparation method of described mouth care chewable tablet mainly comprises the following steps: by mass fraction be 0.5% ~ 20% Process of Total Flavonoids in Drynaria Fortunei and mass fraction be 5% ~ 50% tea polyphenols and the filler of surplus, disintegrating agent, correctives, wetting agent, binding agent and lubricant pulverize, sieve, mix, granulate, dry, suppress, pack.
Described mouth care chewable tablet more specifically preparation method mainly comprises the following steps: by mass fraction be 1% ~ 5% Process of Total Flavonoids in Drynaria Fortunei and mass fraction be 15% ~ 25% tea polyphenols and the filler of surplus, correctives, wetting agent, binding agent and lubricant pulverize, cross 80 mesh sieves, mixing, granulation, drying, cross 16 mesh sieve granulate, mixing, tabletting, to pack.
The application of described mouth care chewable tablet: mouth care chewable tablet is contained in mouth, gargles with clear water after chewing.
The invention has the advantages that: by adding Process of Total Flavonoids in Drynaria Fortunei and tea polyphenols in oral cavity chewable tablet, the facilitation utilizing tea polyphenols to have the reparation of periodontal tissue, regeneration and reconstruction general oral inflammation and the good health care of oropharynx inflammation and therapeutical effect and Process of Total Flavonoids in Drynaria Fortunei, strengthens oral health further.Because Process of Total Flavonoids in Drynaria Fortunei and tea polyphenols are natural materials and for environmentally friendly, no side effects, wrongly takes and can not cause untoward reaction, and safety is high, and all soluble in water, be easy to remove.In addition, its preparation method is simple, cost is low, and application is convenient, only need chew a few minutes in mouth, can not because of suck cause unhappy.
Because green tea contains the necessary chemical composition of multiple human body, there is different physiological roles, prevention and health-care effect can be played to human body, wherein tea polyphenols is topmost functional component, there is anti-cancer anti-inflammation, scavenging free radicals, antioxidation, improve immunity, angiocardiopathy preventing etc.There is Folium Camelliae sinensis very early to prevent and treat the prescription of oral inflammation in China, as anti-treating dental ulcer, aphtha, oral inflammation, gingival hemorrhage, halitosis etc., abroad also studies have found that, drink tea and can reduce the generation of people and experimental animal dental caries.The oral-cavity article of the existing preventing decayed tooth deodorizing tooth containing tea, chewing gum, spray is sold in the market, and its main composition is all tea polyphenols.In recent years, green tea achieves new progress in caries prevention, periodontal disease and gingivitis.Foreign study shows, tea polyphenols can prevention and therapy dental caries, periodontitis.Prove that tea polyphenols can suppress the growth of Streptococcus mutans through experiment, thus reduced and prevented the generation of cavity, in addition, p.prand drunk tea and also can obviously reduce child's caries prevalence rate.Research find service property (quality) percentage composition be 0.2% tea polyphenols collutory brush teeth, health volunteer's plaque index and gingival index can be made obviously to reduce, and contrast general chemistry toothpaste and compare and have significant difference.Separately studies have found that service property (quality) percentage composition be 1% tea polyphenols toothpaste brush teeth, antibacterial summary, bacillus and spirochetal quantity to be made in patients with periodontitis gingival sulcus obviously to decline.Tea polyphenols has obvious inhibitory action to pathogen such as Bacillus typhi, Salmonella paratyphi, golden yellow staphylococcus haemolyticus, streptococcus, dysentery bacteriums, wherein staphylococcus, streptococcus effect are better than sulfathiazole, stronger than baicalin 3-15 times to dysentery bacterium, S. sonnei, staphylococcus aureus, bacillus pyocyaneus, Salmonella paratyphi and colibacillary effect.In addition, tea polyphenols also has inhibitory action to virus, and 0.1ul/ml Folium Camelliae sinensis extract process influenza A virus or Type B are after one hour, and suppression ratio reaches 88% and 80% respectively, and tea polyphenols also has inhibitory action to Human reoviruslike agent.It can thus be appreciated that Green Tea Polyphenols has good health care and therapeutical effect to general inflammation and oropharynx inflammation.
Rhizoma Drynariae is the dry rhizome of Plants of Polypodiaceae Mongolian oak Herba pteridii latiusculi Drynaria fortune (Kunze) J.Sm, another name monkey Rhizoma Zingiberis Recens, Mao Jiang etc., is distributed in Central-South, southwest and Zhejiang, Jiangxi, Fujian, Taiwan; Bitter in the mouth, warm in nature, return Liver and kidney warp, there is the kidney invigorating bone strengthening, continuous effect of hindering pain relieving, for lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, fall wink frustrate, injured bone.Utilize the methods such as soak by water, alcohol extraction, ultrasonic extraction, purification by macroporous resin effectively can extract Rhizoma Drynariae.Modern pharmacology research shows that it contains the compositions such as naringin, neoeriocitrin, cupreol, protocatechuic acid, butanediol, and Rhizoma Drynariae utilizes calcium absorption at promotion bone, improves blood calcium, serum phosphorus levels, is conducive to the effect of bone calcification and bone mineralization.Animal experiment shows that Rhizoma Drynariae can promote collagen fiber hyperplasia and proteoglycan synthesis in substrate, be beneficial to callus formation, promote osteoblast to enliven and the synthesis of alkali phosphatase and secretion, Rhizoma Drynariae has useful regulating action to TGF-β 1mRNA, BMP-2mRNA gene expression simultaneously.In addition, research shows that Rhizoma Drynariae suppresses IL-6, TNF-α to discharge in addition and promotes the effect of IL-4 secretion, and IL-6 and TNF-α is strong bone resorption agent, and IL-4 is bone resorption inhibitor.Process of Total Flavonoids in Drynaria Fortunei capsule is at Clinical practice, be used for the treatment of senile osteoporosis, bone density increased and the improvement of bone biomechanical index, there is good effect, and the alkali phosphatase that can improve in the content of calcium in patient's blood, blood and sclerotin, promote the generation of bone.Research display in field, oral cavity, osteomiosis complementary energy makes the maintenance phase of experimental animal correction tooth shorten, and can suppress frontal resorption, promote Regeneration of Alveolar Bone etc.The effect that induction people periodontal ligament cell transforms to osteoblast, has no significant effect the expression of people's periodontal cell Bone Gla protein.These research prompting Rhizoma Drynariae also have facilitation to the reparation of periodontal tissue, regeneration and reconstruction.
Detailed description of the invention:
Below in conjunction with specific embodiment, the present invention is described in further detail.
Embodiment 1:
Component and the mass fraction thereof of oral cavity chewable tablet of the present invention are as follows: Process of Total Flavonoids in Drynaria Fortunei is 0.5%, tea polyphenols is 10%, and microcrystalline Cellulose is 15%, and sucrose is 20%, mannitol is 10%, xylitol is 22%, and Mentholum is 3%, and Oleum menthae is 3.5%, sodium lauryl sulphate is 2%, sodium cocoyl glycinate is 3%, and starch slurry is 10%, and magnesium stearate is 1%.
Process of Total Flavonoids in Drynaria Fortunei, tea polyphenols, microcrystalline Cellulose, sucrose, mannitol, xylitol, Mentholum, Oleum menthae, sodium lauryl sulphate, sodium cocoyl glycinate are weighed up rear pulverizing according to above-mentioned respective amount, cross 80 mesh sieves, mixing, with mass fraction be 10% starch slurry granulate, dry, cross 16 mesh sieve granulate, additional mass fraction is the magnesium stearate of 1%, mixing, tabletting, packs.
Get obtained chewable tablet and be placed in mouth, slowly chew to tablet powdered, gargle with about about 20ml clear water, tell, then gargle 1 ~ 2 time with clear water.
After this oral cavity chewable tablet uses, implication is more pure and fresh, and use and effectively can alleviate oral inflammation in more than one week, the phenomenon such as oral ulcer, gingival hemorrhage is alleviated gradually.
Embodiment 2:
Component and the mass fraction thereof of oral cavity chewable tablet of the present invention are as follows: Process of Total Flavonoids in Drynaria Fortunei is 1%, and tea polyphenols is 15%, and starch is 20%, sucrose is 5%, and dextrin is 10%, and mannitol is 5%, xylitol is 10%, and glucose is 5%, and citric acid is 3%, aspartame is 3%, and stevioside is 2%, and saccharin sodium is 3%, Mentholum is 2%, and Oleum menthae is 2%, and sodium lauryl sulphate is 2%, alkyl amido betaine is 2%, and polyvinylpyrrolidone is 8%, and micropowder silica gel is 2%.
Process of Total Flavonoids in Drynaria Fortunei, tea polyphenols, starch, sucrose, dextrin, mannitol, xylitol, glucose, citric acid, aspartame, stevioside, saccharin sodium, Mentholum, Oleum menthae, sodium lauryl sulphate, alkyl amido betaine are weighed up rear pulverizing according to above-mentioned respective amount, cross 80 mesh sieves, mixing, with mass fraction be 8% polyvinylpyrrolidone granulate, dry, cross 16 mesh sieve granulate, additional mass fraction is the micropowder silica gel of 2%, mixing, tabletting, packs.
Get obtained chewable tablet and be placed in mouth, slowly chew to tablet powdered, gargle with about about 20ml clear water, tell, then gargle 1 ~ 2 time with clear water.
This oral cavity chewable tablet mouthfeel is better, can effective cleaning oral cavity after using, and uses and can find that plaque index and gingival index obviously reduce after 1 ~ 2 month.
Embodiment 3:
Component and the mass fraction thereof of oral cavity chewable tablet of the present invention are as follows: Process of Total Flavonoids in Drynaria Fortunei is 2%, and tea polyphenols is 20%, and sucrose is 15%, mannitol is 5%, sorbitol is 15%, and xylitol is 12%, and glucose is 3%, citric acid is 5%, saccharin sodium is 5%, and sodium cocoyl glycinate is 3%, and starch slurry is 6%, carboxymethyl cellulose is 6%, and magnesium stearate is 3%.
Process of Total Flavonoids in Drynaria Fortunei, tea polyphenols, sucrose, mannitol, sorbitol, xylitol, glucose, citric acid, saccharin sodium, sodium cocoyl glycinate are weighed up rear pulverizing according to above-mentioned respective amount, cross 80 mesh sieves, mixing, with mass fraction be 6% starch slurry and mass fraction be 6% carboxymethyl cellulose granulate, dry, cross 16 mesh sieve granulate, additional mass fraction is the magnesium stearate of 3%, mixing, tabletting, packs.
Get obtained chewable tablet and be placed in mouth, slowly chew to tablet powdered, gargle with about about 20ml clear water, tell, then gargle 1 ~ 2 time with clear water.
After using this chewable tablet, implication is more pure and fresh, halitosis phenomenon improves, plaque index and gingival index obviously reduce, use and can alleviate oral inflammation in more than one week, gingival hemorrhage phenomenon reduces, use 1 ~ 3 month oral inflammation and oropharynx inflammation to be clearly better, use half a year, above Periodontal Status also improved.
Embodiment 4:
Component and the mass fraction thereof of oral cavity chewable tablet of the present invention are as follows: Process of Total Flavonoids in Drynaria Fortunei is 3%, tea polyphenols is 25%, dextrin is 15%, lactose is 20%, and aspartame is 23%, and sodium lauryl sulphate is 1%, sodium cocoyl glycinate is 2%, alkyl amido betaine is 2%, and hypromellose is 7%, and Pulvis Talci is 2%.
Process of Total Flavonoids in Drynaria Fortunei, tea polyphenols, dextrin, lactose, aspartame, sodium lauryl sulphate, sodium cocoyl glycinate, alkyl amido betaine are weighed up rear pulverizing according to above-mentioned respective amount, cross 80 mesh sieves, mixing, with mass fraction be 7% hypromellose granulate, dry, cross 16 mesh sieve granulate, additional mass fraction is the Pulvis Talci of 2%, mixing, tabletting, packs.
Get obtained chewable tablet and be placed in mouth, slowly chew to tablet powdered, gargle with about about 20ml clear water, tell, then gargle 1 ~ 2 time with clear water.
After using this chewable tablet, implication is more pure and fresh, and oral inflammation is necessarily alleviated.
Embodiment 5:
Component and the mass fraction thereof of oral cavity chewable tablet of the present invention are as follows: Process of Total Flavonoids in Drynaria Fortunei is 4%, tea polyphenols is 25%, and sucrose is 3%, and lactose is 28%, mannitol is 5%, xylitol is 15%, and glucose is 3%, and citric acid is 2%, Mentholum is 2%, sodium lauryl sulphate is 2%, and starch slurry is 10%, and hydrogenated vegetable oil is 1%.
Process of Total Flavonoids in Drynaria Fortunei, tea polyphenols, sucrose, lactose, mannitol, xylitol, glucose, citric acid, Mentholum, sodium lauryl sulphate are weighed up rear pulverizing according to above-mentioned respective amount, cross 80 mesh sieves, mixing, with mass fraction be 10% starch slurry granulate, dry, cross 16 mesh sieve granulate, additional mass fraction is the hydrogenated vegetable oil of 1%, mixing, tabletting, packs.
Get obtained chewable tablet and be placed in mouth, slowly chew to tablet powdered, gargle with about about 20ml clear water, tell, then gargle 1 ~ 2 time with clear water.
After using this chewable tablet a period of time, plaque index and gingival index obviously reduce.
Embodiment 6:
Component and the mass fraction thereof of oral cavity chewable tablet of the present invention are as follows: Process of Total Flavonoids in Drynaria Fortunei is 5%, and tea polyphenols is 20%, and pregelatinized Starch is 26%, xylitol is 25%, sodium lauryl sulphate is 1%, and sodium cocoyl glycinate is 1%, and alkyl amido betaine is 2%, sodium cocoyl glutamate is 1%, polyvinylpyrrolidone is 5%, and hypromellose is 9%, and magnesium stearate is 2%, micropowder silica gel is 2%, and Polyethylene Glycol is 1%.
Process of Total Flavonoids in Drynaria Fortunei, tea polyphenols, pregelatinized Starch, xylitol, sodium lauryl sulphate, sodium cocoyl glycinate, alkyl amido betaine, sodium cocoyl glutamate are weighed up rear pulverizing according to above-mentioned respective amount, cross 80 mesh sieves, mixing, with mass fraction be 5% polyvinylpyrrolidone and mass fraction be 9% hypromellose granulate, dry, cross 16 mesh sieve granulate, additional mass fraction be 2% magnesium stearate, mass fraction be 2% micropowder silica gel and mass fraction be the Polyethylene Glycol of 1%, mixing, tabletting, packs.
Get obtained chewable tablet and be placed in mouth, slowly chew to tablet powdered, gargle with about about 20ml clear water, tell, then gargle 1 ~ 2 time with clear water.
After using this chewable tablet, implication is more pure and fresh, and oral inflammation is eased, and gingival hemorrhage phenomenon reduces.
Embodiment 7:
Component and the mass fraction thereof of oral cavity chewable tablet of the present invention are as follows: Process of Total Flavonoids in Drynaria Fortunei is 6%, and tea polyphenols is 10%, and microcrystalline Cellulose is 15%, sucrose is 2%, mannitol is 15%, and xylitol is 20%, and aspartame is 5%, stevioside is 5%, Oleum menthae is 3%, and sodium lauryl sulphate is 2%, and sodium cocoyl glutamate is 2%, starch slurry is 11%, and micropowder silica gel is 4%.
Process of Total Flavonoids in Drynaria Fortunei, tea polyphenols, microcrystalline Cellulose, sucrose, mannitol, xylitol, aspartame, stevioside, Oleum menthae, sodium lauryl sulphate, sodium cocoyl glutamate are weighed up rear pulverizing according to above-mentioned respective amount, cross 80 mesh sieves, mixing, with mass fraction be 11% starch slurry granulate, dry, cross 16 mesh sieve granulate, additional mass fraction is the micropowder silica gel of 4%, mixing, tabletting, packs.
Get obtained chewable tablet and be placed in mouth, slowly chew to tablet powdered, gargle with about about 20ml clear water, tell, then gargle 1 ~ 2 time with clear water.
Eurodonticus use this chewable tablet after three months Periodontal Status take a turn for the better, pain condition takes a turn for the better to some extent.
Embodiment 8:
Component and the mass fraction thereof of oral cavity chewable tablet of the present invention are as follows: Process of Total Flavonoids in Drynaria Fortunei is 7%, and tea polyphenols is 15%, and starch is 20%, sorbitol is 16%, and stevioside is 25%, and alkyl amido betaine is 3%, starch slurry is 5%, and carboxymethyl cellulose is 7%, and magnesium stearate is 2%.
Process of Total Flavonoids in Drynaria Fortunei, tea polyphenols, starch, sorbitol, stevioside, alkyl amido betaine are weighed up rear pulverizing according to above-mentioned respective amount, cross 80 mesh sieves, mixing, with mass fraction be 5% starch slurry and mass fraction be 7% carboxymethyl cellulose granulate, dry, cross 16 mesh sieve granulate, additional mass fraction is the magnesium stearate of 2%, mixing, tabletting, packs.
Get obtained chewable tablet and be placed in mouth, slowly chew to tablet powdered, gargle with about about 20ml clear water, tell, then gargle 1 ~ 2 time with clear water.
After oral inflammation patient uses this chewable tablet, the situation such as gingival hemorrhage is alleviated to some extent.
Embodiment 9:
Component and the mass fraction thereof of oral cavity chewable tablet of the present invention are as follows: Process of Total Flavonoids in Drynaria Fortunei is 8%, and tea polyphenols is 20%, and microcrystalline Cellulose is 25%, sucrose is 5%, mannitol is 5%, and xylitol is 18%, and sodium lauryl sulphate is 1%, sodium cocoyl glycinate is 2%, alkyl amido betaine is 1%, and sodium cocoyl glutamate is 2%, and polyvinylpyrrolidone is 6%, hypromellose is 4%, and Polyethylene Glycol is 3%.
Process of Total Flavonoids in Drynaria Fortunei, tea polyphenols, microcrystalline Cellulose, sucrose, mannitol, xylitol, sodium lauryl sulphate, sodium cocoyl glycinate, alkyl amido betaine, sodium cocoyl glutamate are weighed up rear pulverizing according to above-mentioned respective amount, cross 80 mesh sieves, mixing, with mass fraction be 6% polyvinylpyrrolidone and mass fraction be 4% hypromellose granulate, dry, cross 16 mesh sieve granulate, additional mass fraction is the Polyethylene Glycol of 3%, mixing, tabletting, packs.
Get obtained chewable tablet and be placed in mouth, slowly chew to tablet powdered, gargle with about about 20ml clear water, tell, then gargle 1 ~ 2 time with clear water.
After using this chewable tablet, implication is more pure and fresh, and plaque index and gingival index can obviously reduce.
Embodiment 10:
Component and the mass fraction thereof of oral cavity chewable tablet of the present invention are as follows: Process of Total Flavonoids in Drynaria Fortunei is 9%, and tea polyphenols is 25%, and starch is 12%, and dextrin is 18%, and mannitol is 23%, and Mentholum is 3%, and sodium lauryl sulphate is 2%, and carboxymethyl cellulose is 8%.
Process of Total Flavonoids in Drynaria Fortunei, tea polyphenols, starch, dextrin, mannitol, Mentholum are weighed up rear pulverizing according to above-mentioned respective amount, cross 80 mesh sieves, mixing, with mass fraction be 8% carboxymethyl cellulose granulate, dry, cross 16 mesh sieve granulate, additional mass fraction is the sodium lauryl sulphate of 2%, mixing, tabletting, packs.
Get obtained chewable tablet and be placed in mouth, slowly chew to tablet powdered, gargle with about about 20ml clear water, tell, then gargle 1 ~ 2 time with clear water.
After using this chewable tablet, implication is more pure and fresh, and plaque index and gingival index all decrease, and after using a period of time, inflammation disappears.
Embodiment 11:
Component and the mass fraction thereof of oral cavity chewable tablet of the present invention are as follows: Process of Total Flavonoids in Drynaria Fortunei is 10%, and tea polyphenols is 30%, and sucrose is 20%, and glucose is 24%, and sodium lauryl sulphate is 3%, and alkyl amido betaine is 1%, and starch slurry is 10%, and magnesium stearate is 2%.
Process of Total Flavonoids in Drynaria Fortunei, tea polyphenols, sucrose, glucose, sodium lauryl sulphate, alkyl amido betaine are weighed up rear pulverizing according to above-mentioned respective amount, cross 80 mesh sieves, mixing, with mass fraction be 10% starch slurry granulate, dry, cross 16 mesh sieve granulate, additional mass fraction is the magnesium stearate of 2%, mixing, tabletting, packs.
Get obtained chewable tablet and be placed in mouth, slowly chew to tablet powdered, gargle with about about 20ml clear water, tell, then gargle 1 ~ 2 time with clear water.
After using this chewable tablet, oral inflammation and oropharynx inflammation are eased all to a certain extent.
Embodiment 12:
Component and the mass fraction thereof of oral cavity chewable tablet of the present invention are as follows: Process of Total Flavonoids in Drynaria Fortunei is 1%, tea polyphenols is 10%, dextrin is 15%, pregelatinized Starch is 20%, and mannitol is 13%, and xylitol is 15%, glucose is 15%, sodium lauryl sulphate is 4%, and polyvinylpyrrolidone is 6%, and micropowder silica gel is 1%.
Process of Total Flavonoids in Drynaria Fortunei, tea polyphenols, dextrin, pregelatinized Starch, mannitol, xylitol, glucose, sodium lauryl sulphate are weighed up rear pulverizing according to above-mentioned respective amount, cross 80 mesh sieves, mixing, with mass fraction be 6% polyvinylpyrrolidone granulate, dry, cross 16 mesh sieve granulate, additional mass fraction is the micropowder silica gel of 1%, mixing, tabletting, packs.
Get obtained chewable tablet and be placed in mouth, slowly chew to tablet powdered, gargle with about about 20ml clear water, tell, then gargle 1 ~ 2 time with clear water.
After using this chewable tablet, implication is more pure and fresh, and inflammation and gingival hemorrhage phenomenon reduce.
Embodiment 13:
Component and the mass fraction thereof of oral cavity chewable tablet of the present invention are as follows: Process of Total Flavonoids in Drynaria Fortunei is 2%, tea polyphenols is 15%, and lactose is 14%, and sorbitol is 20%, xylitol is 12%, glucose is 5%, and citric acid is 5%, and aspartame is 5%, stevioside is 8%, sodium cocoyl glycinate is 5%, and starch slurry is 7%, and Polyethylene Glycol is 2%.
Process of Total Flavonoids in Drynaria Fortunei, tea polyphenols, lactose, sorbitol, xylitol, glucose, citric acid, aspartame, stevioside, sodium cocoyl glycinate are weighed up rear pulverizing according to above-mentioned respective amount, cross 80 mesh sieves, mixing, with mass fraction be 7% starch slurry granulate, dry, cross 16 mesh sieve granulate, additional mass fraction is the Polyethylene Glycol of 2%, mixing, tabletting, packs.
Get obtained chewable tablet and be placed in mouth, slowly chew to tablet powdered, gargle with about about 20ml clear water, tell, then gargle 1 ~ 2 time with clear water.
After using this chewable tablet, dental caries, periodontitis all make moderate progress, and plaque index and gingival index reduce.
Embodiment 14:
Component and the mass fraction thereof of oral cavity chewable tablet of the present invention are as follows: Process of Total Flavonoids in Drynaria Fortunei is 20%, tea polyphenols is 5%, microcrystalline Cellulose is 16%, pregelatinized Starch is 12%, and xylitol is 20%, and stevioside is 5%, Oleum menthae is 5%, alkyl amido betaine is 6%, and hypromellose is 8%, and magnesium stearate is 3%.
Process of Total Flavonoids in Drynaria Fortunei, tea polyphenols, microcrystalline Cellulose, pregelatinized Starch, xylitol, stevioside, Oleum menthae, alkyl amido betaine are weighed up rear pulverizing according to above-mentioned respective amount, cross 80 mesh sieves, mixing, with mass fraction be 8% hypromellose granulate, dry, cross 16 mesh sieve granulate, additional mass fraction is the magnesium stearate of 3%, mixing, tabletting, packs.
Get obtained chewable tablet and be placed in mouth, slowly chew to tablet powdered, gargle with about about 20ml clear water, tell, then gargle 1 ~ 2 time with clear water.
After using this chewable tablet a period of time, the symptom such as oral ulcer, aphtha, oral inflammation, gingival hemorrhage, halitosis is necessarily alleviated.
Embodiment 15:
Component and the mass fraction thereof of oral cavity chewable tablet of the present invention are as follows: Process of Total Flavonoids in Drynaria Fortunei is 4%, tea polyphenols is 50%, sucrose is 15%, mannitol is 15%, and sodium lauryl sulphate is 3%, and sodium cocoyl glycinate is 4%, sodium cocoyl glutamate is 1%, carboxymethyl cellulose is 4%, and micropowder silica gel is 2%, and Polyethylene Glycol is 2%.
Process of Total Flavonoids in Drynaria Fortunei, tea polyphenols, sucrose, mannitol, sodium lauryl sulphate, sodium cocoyl glycinate, sodium cocoyl glutamate are weighed up rear pulverizing according to above-mentioned respective amount, cross 80 mesh sieves, mixing, with mass fraction be 4% carboxymethyl cellulose granulate, dry, cross 16 mesh sieve granulate, additional mass fraction be 2% micropowder silica gel and mass fraction be the Polyethylene Glycol of 2%, mixing, tabletting, packs.
Get obtained chewable tablet and be placed in mouth, slowly chew to tablet powdered, gargle with about about 20ml clear water, tell, then gargle 1 ~ 2 time with clear water.
This chewable tablet mouthfeel is better, uses rear plaque index and gingival index all to decrease.
Embodiment 16:
Component and the mass fraction thereof of oral cavity chewable tablet of the present invention are as follows: Process of Total Flavonoids in Drynaria Fortunei is 5%, and tea polyphenols is 20%, and sorbitol is 30%, saccharin sodium is 27%, and sodium cocoyl glutamate is 3%, and carboxymethyl cellulose is 10%, magnesium stearate is 3%, and hydrogenated vegetable oil is 2%.
Process of Total Flavonoids in Drynaria Fortunei, tea polyphenols, sorbitol, saccharin sodium, sodium cocoyl glutamate are weighed up rear pulverizing according to above-mentioned respective amount, cross 80 mesh sieves, mixing, with mass fraction be 10% carboxymethyl cellulose granulate, dry, cross 16 mesh sieve granulate, additional mass fraction be 3% magnesium stearate and mass fraction be the hydrogenated vegetable oil of 2%, mixing, tabletting, packs.
Get obtained chewable tablet and be placed in mouth, slowly chew to tablet powdered, gargle with about about 20ml clear water, tell, then gargle 1 ~ 2 time with clear water.
After using this chewable tablet, implication is more pure and fresh, and oral inflammation and oropharynx inflammation are alleviated gradually.
Embodiment 17:
Component and the mass fraction thereof of oral cavity chewable tablet of the present invention are as follows: Process of Total Flavonoids in Drynaria Fortunei is 6%, tea polyphenols is 15%, microcrystalline Cellulose is 12%, and pregelatinized Starch is 14%, and mannitol is 5%, xylitol is 25%, citric acid is 5%, and sodium cocoyl glycinate is 1%, and alkyl amido betaine is 3%, hypromellose is 11%, and magnesium stearate is 3%.
Process of Total Flavonoids in Drynaria Fortunei, tea polyphenols, microcrystalline Cellulose, pregelatinized Starch, mannitol, xylitol, citric acid, sodium cocoyl glycinate and alkyl amido betaine are weighed up rear pulverizing according to above-mentioned respective amount, cross 80 mesh sieves, mixing, with mass fraction be 11% hypromellose granulate, dry, cross 16 mesh sieve granulate, additional mass fraction is the magnesium stearate of 3%, mixing, tabletting, packs.
Get obtained chewable tablet and be placed in mouth, slowly chew to tablet powdered, gargle with about about 20ml clear water, tell, then gargle 1 ~ 2 time with clear water.
After using this chewable tablet, implication is more pure and fresh, and plaque index and gingival index reduce, and oral ulcer and the phenomenon such as gingival hemorrhage, halitosis reduce.
Embodiment 18:
Component and the mass fraction thereof of oral cavity chewable tablet of the present invention are as follows: Process of Total Flavonoids in Drynaria Fortunei is 5%, and tea polyphenols is 25%, and sucrose is 13%, sorbitol is 10%, and citric acid is 25%, and sodium cocoyl glutamate is 6%, starch slurry is 6%, and carboxymethyl cellulose is 7%, and magnesium stearate is 3%.
Process of Total Flavonoids in Drynaria Fortunei, tea polyphenols, sucrose, sorbitol, citric acid, sodium cocoyl glutamate are weighed up rear pulverizing according to above-mentioned respective amount, cross 80 mesh sieves, mixing, with mass fraction be 6% starch slurry and mass fraction be 7% carboxymethyl cellulose granulate, dry, cross 16 mesh sieve granulate, additional mass fraction is the magnesium stearate of 3%, mixing, tabletting, packs.
Get obtained chewable tablet and be placed in mouth, slowly chew to tablet powdered, gargle with about about 20ml clear water, tell, then gargle 1 ~ 2 time with clear water.
After using this chewable tablet, plaque index and gingival index reduce, breath freshening, and inflammation reduces.
Embodiment 19:
Component and the mass fraction thereof of oral cavity chewable tablet of the present invention are as follows: Process of Total Flavonoids in Drynaria Fortunei is 3%, and tea polyphenols is 20%, and starch is 28%, mannitol is 15%, and xylitol is 10%, and Mentholum is 5%, sodium lauryl sulphate is 5%, and starch slurry is 12%, and hydrogenated vegetable oil is 2%.
Process of Total Flavonoids in Drynaria Fortunei, tea polyphenols, starch, mannitol, xylitol, Mentholum, sodium lauryl sulphate are weighed up rear pulverizing according to above-mentioned respective amount, cross 80 mesh sieves, mixing, with mass fraction be 12% starch slurry granulate, dry, cross 16 mesh sieve granulate, additional mass fraction is the hydrogenated vegetable oil of 2%, mixing, tabletting, packs.
Get obtained chewable tablet and be placed in mouth, slowly chew to tablet powdered, gargle with about about 20ml clear water, tell, then gargle 1 ~ 2 time with clear water.
After using this chewable tablet, implication is more pure and fresh, and plaque index and gingival index reduce, and the phenomenon such as gingival hemorrhage, halitosis takes a turn for the better.
Embodiment 20:
Component and the mass fraction thereof of oral cavity chewable tablet of the present invention are as follows: Process of Total Flavonoids in Drynaria Fortunei is 2%, and tea polyphenols is 20%, and dextrin is 27%, and xylitol is 20%, stevioside is 5%, and Oleum menthae is 5%, and sodium lauryl sulphate is 5%, starch slurry is 7%, and polyvinylpyrrolidone is 7%, and magnesium stearate is 2%.
Process of Total Flavonoids in Drynaria Fortunei, tea polyphenols, dextrin, xylitol, stevioside, Oleum menthae, sodium lauryl sulphate are weighed up rear pulverizing according to above-mentioned respective amount, cross 80 mesh sieves, mixing, with mass fraction be 7% starch slurry and mass fraction be 7% polyvinylpyrrolidone granulate, dry, cross 16 mesh sieve granulate, additional mass fraction is the magnesium stearate of 2%, mixing, tabletting, packs.
Get obtained chewable tablet and be placed in mouth, slowly chew to tablet powdered, gargle with about about 20ml clear water, tell, then gargle 1 ~ 2 time with clear water.
After using this chewable tablet, implication is more pure and fresh, and halitosis phenomenon improves, and plaque index and gingival index obviously reduce, and uses 1 ~ 3 month oral inflammation and oropharynx inflammation obviously to improve, and use half a year, above Periodontal Status was further strengthened.
Claims (2)
1. an oral cavity chewable tablet, it is characterized in that: containing mass fraction in every tablet of described chewable tablet is the Process of Total Flavonoids in Drynaria Fortunei of 2%, mass fraction is tea polyphenols and the pharmaceutically acceptable mixed carrier of surplus of 20%, described mixed carrier comprises the sucrose that mass fraction is 15%, mass fraction is the mannitol of 5%, mass fraction is the sorbitol of 15%, mass fraction is the xylitol of 12%, mass fraction is the glucose of 3%, mass fraction is the citric acid of 5%, mass fraction is the saccharin sodium of 5%, mass fraction is the sodium cocoyl glycinate of 3%, mass fraction is the starch slurry of 6%, mass fraction is the carboxymethyl cellulose of 6%, mass fraction is the magnesium stearate of 3%.
2. the preparation method of an oral cavity chewable tablet according to claim 1, it is characterized in that: it comprise the steps: by mass fraction be 2% Process of Total Flavonoids in Drynaria Fortunei, mass fraction be 20% tea polyphenols and the pharmaceutically acceptable mixed carrier of surplus, pulverize, sieve, mix, granulate, dry, suppress, pack; Described mixed carrier comprise mass fraction be 15% sucrose, the mass fraction mannitol that is 5%, the mass fraction sorbitol that is 15%, the mass fraction xylitol that is 12%, the mass fraction glucose that is 3%, the mass fraction citric acid that is 5%, the mass fraction saccharin sodium that is 5%, the mass fraction sodium cocoyl glycinate that is 3%, the mass fraction starch slurry that is 6%, mass fraction be 6% carboxymethyl cellulose, mass fraction be the magnesium stearate of 3%.
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| CN104585758B (en) * | 2015-01-12 | 2017-06-30 | 李元勋 | A kind of angustata alcohol disintoxication chewable tablet and preparation method thereof |
| CN104970997A (en) * | 2015-06-18 | 2015-10-14 | 梁振权 | Gingival bleeding prevention toothpaste and preparation method thereof |
| CN108308611A (en) * | 2017-12-29 | 2018-07-24 | 河南健特生物科技集团有限公司 | A kind of chewable tablets and preparation method thereof for capableing of fresh breath |
| CN108142944A (en) * | 2017-12-29 | 2018-06-12 | 河南健特生物科技集团有限公司 | For alleviating chewable tablets of endogenous halitosis and preparation method thereof |
| US11911492B2 (en) | 2018-05-14 | 2024-02-27 | The Procter & Gamble Company | Oral care compositions comprising metal ions |
| CA3100060C (en) | 2018-05-14 | 2024-02-27 | The Procter & Gamble Company | Oral care compositions comprising metal ions |
| CN108888770A (en) * | 2018-07-30 | 2018-11-27 | 郑州兰茜生物工程有限公司 | A kind of oral health agent of strengthening tooth antibacterial anti-inflammatory and preparation method thereof |
| CN109275907A (en) * | 2018-08-09 | 2019-01-29 | 福建农林大学 | A kind of lemon tea polyphenols chewable tablets and preparation method thereof |
| CN109497421A (en) * | 2018-12-04 | 2019-03-22 | 怀化学院 | Rice enriched-Se plumule chewable tablets and preparation method thereof |
| JP7129957B2 (en) * | 2019-08-19 | 2022-09-02 | 信越化学工業株式会社 | Orally disintegrating tablet composition, method for producing the same, and orally disintegrating tablet using the same and method for producing the same |
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