CN101721336B - Gargle with drinking safety and preparation method thereof - Google Patents
Gargle with drinking safety and preparation method thereof Download PDFInfo
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- CN101721336B CN101721336B CN2008102018165A CN200810201816A CN101721336B CN 101721336 B CN101721336 B CN 101721336B CN 2008102018165 A CN2008102018165 A CN 2008102018165A CN 200810201816 A CN200810201816 A CN 200810201816A CN 101721336 B CN101721336 B CN 101721336B
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Abstract
The invention relates to gargle with the drinking safety, comprising the following components by weight percent: 0.1-0.5 percent of tea polyphenols, 0.05-0.3 percent of magnolol, 0.05-0.3 percent of paeonol, 0.01-0.1 percent of phytic acid dodecasodium salt, 0.5-3 percent of glycyrrhizic acid, 1-5 percent of ethanol, 0.05-0.5 percent of mentha haplocalyx, 0.001-0.01 percent of essence, 0.05-0.2 percent of propylgallate, 0.01-0.1 percent of sodium cyclamate, 0.05-0.5 percent of macromolecule suspending agent, 0.3-2 percent of surface active agent and the balance of water. A preparation method of the gargle comprises the following steps of: adding tea polyphenols, magnolol, paeonol, propylgallate, mentha haplocalyx and essence into the ethanol according to the content and components, stirring for dissolving to obtain solution A; adding the phytic acid dodecasodium salt, glycyrrhizic acid, sodium cyclamate, macromolecule suspending agent and surface active agent into water, stirring for dissolving to obtain solution B; slowly adding the solution A into the solution B while stirring, and evenly stirring the mixture solution to obtain the gargle. The gargle has clear appearance, is slightly sweet in the mouth feel and ensures fresh breath after use.
Description
Technical field
The present invention relates to dental care products liquid, relate in particular to a kind of collutory with drinking safety and preparation method thereof.
Background technology
Along with people's raising of quality of life, oral cavity cleaning becomes the important component part of daily life.The common method of oral cavity cleaning mainly contains two kinds at present, and a kind of is to brush teeth, and a kind of is to gargle.Brush teeth mainly be confined to get up morning after and sleep evening before, gargling then has conveniently characteristics.The collutory kind is a lot of in the market, mostly is greatly chemicals, or the compound recipe of chemicals and Chinese herbal medicine.Owing to can keep collutory residual at the deutostoma intracavity of gargling, even gargle can wrongly take when careless and drink in body, this preparation that contains chemical drugs can have side effects to human body.
Summary of the invention
The present invention is intended to overcome and contains the chemical drugs collutory human body is had the shortcoming of side effect, and a kind of collutory with drinking safety and preparation method thereof is provided.The present invention adopts pure natural plant ingredients, safety non-toxic, and it is harmless to oral cavity tissue to gargle for a long time, drinks in body even wrongly take, also without any side effects to human body.The present invention has also added natural Herba Menthae simultaneously, and the little suffering of mouthfeel is sweet, can dispel halitosis, and the rear breath freshening of gargling is happy refreshing.
A kind of collutory with drinking safety, it comprises each component of following each percetage by weight:
Tea polyphenols, 0.1-0.5;
Magnolol, 0.05-0.3;
Paeonol, 0.05-0.3;
Sodium phytate, 0.01-0.1;
Glycyrrhizic acid, 0.5-3;
Ethanol, 1-5;
Herba Menthae, 0.05-0.5;
Essence, 0.001-0.01;
Propyl gallate, 0.05-0.2;
Cyclamate, 0.01-0.1;
The agent of macromolecule suspending, 0.05-0.5;
Surfactant, 0.3-2;
Water, surplus.
Described collutory, described surfactant are nonionic surfactant or anionic surfactant.
Described collutory, described nonionic surfactant are polyoxyethylene sorbitan ester or fatty alcohol-polyoxyethylene ether.
Described collutory, described anionic surfactant are sodium laurylsulfate.
Described collutory, the agent of described macromolecule suspending are one or more in polyvinylpyrrolidone, hydroxyethyl-cellulose or the sodium carboxymethyl cellulose.
A kind of described preparation method with collutory of drinking safety is: by described content and component, tea polyphenols, magnolol, paeonol, propyl gallate, Herba Menthae, essence are joined in the ethanol, stirring and dissolving gets A liquid; Sodium phytate, glycyrrhizic acid, cyclamate, the agent of macromolecule suspending, surfactant are added to the water, and stirring and dissolving gets B liquid; When stirring, A liquid is slowly added in the B liquid, stir, namely get described collutory.
The present invention utilizes the comprehensive function of tea polyphenols, magnolol, paeonol, sodium phytate, glycyrrhizic acid to suppress the periodontal pathogen, suppresses dissolving phosphorus calcium and tooth enamel, prevents and treats dental caries.The present invention adopts pure natural plant ingredients, safety non-toxic, and it is harmless to oral cavity tissue to gargle for a long time, drinks in body even wrongly take, also without any side effects to human body.The present invention has also added natural Herba Menthae simultaneously, and the little suffering of mouthfeel is sweet, has the halitosis of covering, and the good result of cleaning oral cavity makes breath freshening happy refreshing after gargling.
Particularly:
Tea polyphenols is the general name of Catechin in Tea class, flavonoid, phenolic acids and anthocyan chemical compound, has the multiple efficacies such as antibacterial, sterilization, antitumor, radioprotective.Studies confirm that certain density tea polyphenols can suppress or reduce the quantity of dental plaque and the adhesion on facing thereof, can obviously reduce dental plaque and periodontal disease incidence rate, the effect with caries prevention.In addition, tea polyphenols has good result to removing the methanthiol stink, can remove smoker's halitosis.Tea polyphenols be used for mouth care have inexpensive, the source is abundant, safe and reliable, without obvious pigmentation, without advantages such as cumulative toxicity.
Cortex Magnoliae Officinalis is the QI regulating medicine of commonly using, and the functions such as warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, dampness, expectorant are arranged, and its effective ingredient is that magnolol has stronger inhibitory action to the periodontal pathogen, and good anti-dental caries effect is arranged.
Paeonol has analgesia, antiinflammatory, analgesic and suppress allergic effect, is applied in toothpaste, gargarism, dentifrice, the toothache drops, has reducing swelling and alleviating pain, prevents and treats dental caries, covers halitosis, the good result such as cleaning oral cavity.
Natural sodium phytate can suppress to dissolve the ability of phosphorus calcium and tooth enamel effectively, has anti-dental caries effect, and as cleaning the teeth except the additive of speckle, effect is also fairly good, to dispel smoking patch, the dental surface dirt such as black, yellow is effective especially.
Glycyrrhizic acid is the natural component in the Radix Glycyrrhizae, can suppress oral cavity bacterium, the effect that has tonifying the spleen and stomach, nourishing the lung to arrest cough, heat-clearing and toxic substances removing, mediation implication and eliminate the phlegm.
Collutory of the present invention adopts above-mentioned natural plant composition, safety non-toxic, and it is harmless to oral cavity tissue to gargle for a long time, even drink in body, also without any side effects to human body.Also add natural Herba Menthae in the collutory of the present invention, can dispel halitosis, made breath freshening lasting.
The specific embodiment
Below, in conjunction with specific embodiments, further specify the present invention:
A kind of collutory with drinking safety, it comprises each component of following each percetage by weight:
Tea polyphenols, 0.1-0.5;
Magnolol, 0.05-0.3;
Paeonol, 0.05-0.3;
Sodium phytate, 0.01-0.1;
Glycyrrhizic acid, 0.5-3;
Ethanol, 1-5;
Herba Menthae, 0.05-0.5;
Essence, 0.001-0.01;
Propyl gallate, 0.05-0.2;
Cyclamate, 0.01-0.1;
The agent of macromolecule suspending, 0.05-0.5;
Surfactant, 0.3-2;
Water, surplus.
Described collutory, described surfactant are nonionic surfactant or anionic surfactant.
Described collutory, described nonionic surfactant are polyoxyethylene sorbitan ester or fatty alcohol-polyoxyethylene ether.
Described collutory, described anionic surfactant are sodium laurylsulfate.
Described collutory, the agent of described macromolecule suspending are one or more in polyvinylpyrrolidone, hydroxyethyl-cellulose or the sodium carboxymethyl cellulose.
A kind of described preparation method with collutory of drinking safety is: by described content and component, tea polyphenols, magnolol, paeonol, propyl gallate, Herba Menthae, essence are joined in the ethanol, stirring and dissolving gets A liquid; Sodium phytate, glycyrrhizic acid, cyclamate, the agent of macromolecule suspending, surfactant are added to the water, and stirring and dissolving gets B liquid; When stirring, A liquid is slowly added in the B liquid, stir, namely get described collutory.
Embodiment 1
Tea polyphenols 2.5 grams, magnolol 1 gram, paeonol 2 grams, propyl gallate 1 gram, Herba Menthae 0.5 gram, essence 0.01 gram are joined in ethanol 30 grams, and stirring and dissolving gets A liquid; Sodium phytate 0.5 gram, glycyrrhizic acid 20 grams, cyclamate 0.5 gram, polyvinylpyrrolidone 5 grams, polyoxyethylene 20 sorbitan monooleate 10 grams are joined in water 926.99 grams, and stirring and dissolving gets B liquid; When stirring, A liquid is slowly added in the B liquid, stir, namely get described collutory.
Embodiment 2
Tea polyphenols 5 grams, magnolol 0.5 gram, paeonol 1 gram, propyl gallate 0.5 gram, Herba Menthae 0.3 gram, essence 0.05 gram are joined in ethanol 50 grams, and stirring and dissolving gets A liquid; Sodium phytate 0.2 gram, glycyrrhizic acid 5 grams, cyclamate 1 gram, sodium carboxymethyl cellulose 0.5 gram, sodium laurylsulfate 15 grams are joined in water 920.95 grams, and stirring and dissolving gets B liquid; When stirring, A liquid is slowly added in the B liquid, stir, namely get described collutory.
Embodiment 3
Tea polyphenols 1 gram, magnolol 2 grams, paeonol 1.5 grams, propyl gallate 2 grams, Herba Menthae 0.5 gram, essence 0.1 gram are joined in ethanol 15 grams, and stirring and dissolving gets A liquid; Sodium phytate 1 gram, glycyrrhizic acid 10 grams, cyclamate 0.3 gram, hydroxyethyl-cellulose 1 gram, fatty alcohol-polyoxyethylene ether (AEO9) 5 grams are joined in water 960.6 grams, and stirring and dissolving gets B liquid; When stirring, A liquid is slowly added in the B liquid, stir, namely get described collutory.
Carry out bacteriostatic test according to GB15979-2002 " disposable use hygienic article sanitary standard appendix C ", get the various embodiments described above collutory effect 2min, being 100% to colibacillary average bacteriostasis rate, is 100% to the average bacteriostasis rate of staphylococcus aureus.
Carry out safety testing according to " assessment program and method ", get the various embodiments described above collutory to mouse stomach, each dosage is every 20g body weight gavage 1.0ml, and gavage is three times in one day, Continuous Observation 14 days.Any Deviant Behavior does not appear in mice after the gavage as a result, and more without dead routine number, it is all no abnormal to observe the organs such as the heart, liver, spleen, lung, kidney after dissecting.Show this collutory safety non-toxic.
In sum, rinse product outward appearance of the present invention is as clear as crystal, and the little suffering of mouthfeel is sweet, and the natural Herba Menthae taste of tool can be dispelled halitosis after gargling, and makes breath freshening happy refreshing.Collutory bacteriostasis of the present invention is strong, is 100% to the average bacteriostasis rate of escherichia coli and staphylococcus aureus, can the establishment oral cavity bacterium, safeguard the oral cavity sanitation and hygiene.Collutory safety non-toxic of the present invention, it is harmless to oral cavity tissue to gargle for a long time, even drink in body, also without any side effects to human body.
Claims (2)
1. collutory with drinking safety, it comprises each component of following each percetage by weight:
Tea polyphenols, 0.1-0.5;
Magnolol, 0.05-0.3;
Paeonol, 0.05-0.3;
Sodium phytate, 0.01-0.1;
Glycyrrhizic acid, 0.5-3;
Ethanol, 1-5;
Herba Menthae, 0.05-0.5;
Essence, 0.001-0.01;
Propyl gallate, 0.05-0.2;
Cyclamate, 0.01-0.1;
The agent of macromolecule suspending, 0.05-0.5;
Surfactant, 0.3-2;
Water, surplus;
Described surfactant is polyoxyethylene sorbitan ester, fatty alcohol-polyoxyethylene ether or sodium laurylsulfate;
The agent of described macromolecule suspending is one or more in polyvinylpyrrolidone, hydroxyethyl-cellulose or the sodium carboxymethyl cellulose.
2. the preparation method of collutory according to claim 1 is: by described content and component, tea polyphenols, magnolol, paeonol, propyl gallate, Herba Menthae, essence are joined in the ethanol, stirring and dissolving gets A liquid; Sodium phytate, glycyrrhizic acid, cyclamate, the agent of macromolecule suspending, surfactant are added to the water, and stirring and dissolving gets B liquid; When stirring, A liquid is slowly added in the B liquid, stir, namely get described collutory.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2008102018165A CN101721336B (en) | 2008-10-27 | 2008-10-27 | Gargle with drinking safety and preparation method thereof |
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| CN2008102018165A CN101721336B (en) | 2008-10-27 | 2008-10-27 | Gargle with drinking safety and preparation method thereof |
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| CN101721336A CN101721336A (en) | 2010-06-09 |
| CN101721336B true CN101721336B (en) | 2013-03-06 |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX341440B (en) | 2011-12-15 | 2016-08-18 | Colgate Palmolive Co | Solubilized magnolol analogs. |
| CN104739685A (en) * | 2013-12-26 | 2015-07-01 | 上海利康消毒高科技有限公司 | Gargle containing chlorhexidine gluconate and preparation method thereof |
| CN107921078A (en) * | 2016-05-30 | 2018-04-17 | 江苏奇力康皮肤药业有限公司 | Long-acting bacteriostatic tooth protective gargle |
| CN106821950A (en) * | 2017-01-23 | 2017-06-13 | 衡阳美娇七商贸有限公司 | The oral care composition and its application of a kind of antibacterial and whitening |
| CN112370477A (en) * | 2020-11-03 | 2021-02-19 | 广东启美生物科技有限公司 | Antibacterial oral preparation for refreshing breath, strengthening teeth and protecting gingiva and equipment thereof |
| CN114796260B (en) * | 2022-06-28 | 2022-09-27 | 潍坊护理职业学院 | Oral care composition and preparation method thereof |
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