CN108888770A - A kind of oral health agent of strengthening tooth antibacterial anti-inflammatory and preparation method thereof - Google Patents
A kind of oral health agent of strengthening tooth antibacterial anti-inflammatory and preparation method thereof Download PDFInfo
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- CN108888770A CN108888770A CN201810854374.8A CN201810854374A CN108888770A CN 108888770 A CN108888770 A CN 108888770A CN 201810854374 A CN201810854374 A CN 201810854374A CN 108888770 A CN108888770 A CN 108888770A
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- agent
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- oral health
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- 230000003110 anti-inflammatory effect Effects 0.000 title claims abstract description 19
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
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- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Oncology (AREA)
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- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Abstract
The application belongs to dentistry and oral health science and technology field, and in particular to a kind of oral health agent of strengthening tooth antibacterial anti-inflammatory and preparation method thereof.Said preparation is by dental growth promotor, periodontal gingival soft tissue nourishing agent, natural glue and thickener, anti-caries agent, Biological cross-linker, natural antibacterial antiphlogistic and oral health care agent isoreactivity component, and preservative and the acceptable safety barrier of invention formulation or auxiliary material carry out science and assemble one group of optimization tooth and periodontium can be promoted to grow and repair, the composition of the safe multiple-effect of tooth and periodontosis can be prevented and treated again, then convenient and practical oral health agent is made using a kind of mild technology.Existing drug effect of this product, and have the safety of health food, it is easy to use, it is good effect, quick.
Description
Technical field
The application belongs to dentistry and oral health science and technology field, and in particular to a kind of strengthening tooth antibacterial disappears
Scorching oral health agent and preparation method thereof.
Background technique
Oral health is the important component of whole body health, just proposes mouth disease early in the World Health Organization in 2007
It is a serious public health problem, oral health can directly or indirectly influence whole body health, mouth disease such as dental caries, periodontal
Disease etc. can destroy supporting tissue around hard tooth tissue and tooth, in addition to influencing the functions such as chewing, speech, beauty, can also cause
Social difficult and mental handicape.Some microorganism long-term existence can lead to or aggravate certain general diseases such as coronary disease in oral cavity
Disease, diabetes etc., endanger whole body health, influence quality of life.With the improvement of people ' s living standards with the enhancing of health perception,
Oral health has caused the great attention of people, and modern many people are from the small oral sanitary habit for just having formed " good ", such as
It washes one's hands before meals, brushes teeth gargle after meal, but oral health issue is still troubling, mouth disease illness rate still occupies height not
Under.It is most commonly that dental caries and periodontosis, periodontal disease are that 35 years old or more crowd loses tooth in mouth disease
One of the main reasons, dental caries are commonly called as decayed tooth, decayed tooth, are bacteriosis, can be with secondary pulpitis and periapical inflammation or even energy
Causing alveolar bone and inflammation of jaws, is such as not treated in time, lesion continues to develop, and cavity is formed, destroys disappearance completely to corona eventually,
Its final result developed is that loss of tooth influences feed and and then influences whole body health.According to Second National oral health stream
Row disease learns investigation display, and average each child has 4.56 bad teeth, and the permanent teeth caries prevalence rate of China adult is 49.88%, children's
Primary Caries rate is 76.55%, and periodontosis illness rate is up to 90% or more, and 50 years old or so a middle-aged person's tooth falls off naturally
Common phenomenon is had become, the old tooth number that loses for each person is up to 11 within 65-74 years old, and status causes anxiety, understandable the World Health Organization is by dental caries
Tooth disease and tumour and cardiovascular disease are listed as one of big keypoint control disease of the mankind three, and the health of periodontium is classified as human body and is good for
One of 10 standards of health.Oral health have become measure people's body whether Jian Kang important indicator, improvement oral health shape
Condition has become that Human Oral Cavity healthcare field one important and difficult task.
For the oral health of the mankind, a series of measures for improving oral health are all being released in countries in the world from different perspectives
And scheme.If the U.S. takes in drinking water plus fluorine is with pre- anti-caries if decades ago, Canada, Britain, Australia,
The country such as New Zealand also all uses fluorine-containing drinking water.U.S.'s disease prevention and control centre are even fluorine-containing drinking water and epidemic disease
Seedling, family planning are classified as the greatest health achievement of 20th century 10 together.1989, China was by ministries and commissions such as the Ministry of Public Health, Education Commissions
Joint signature determines that annual September 20th are national Teeth-loving Day.It was promulgated again on September 14th, 2009《Chinese residents oral cavity is strong
Kang Zhinan》Equal files.For the angle of technical products, in order to protect the health of one's mouth, in addition to medicine such as traditional operating medicines
Means are treated the products such as mouth disease, traditional toothpaste and toothbrush dental floss and are kept outside oral hygiene, in recent years various function
The health treatments such as effect medicated toothpaste, mouthwash and chewing gum also come into being.Traditional medical means treatment mouth disease is no doubt
Effectively, but due to oral cavity and the complexity of tooth structure, traditional medicine treatment means are difficult fundamentally to solve dental caries and tooth
All disease problems, existing daily nursing means with product effect is limited does not say, and all oral cavity can not be allowed to keep cleaning in real time
Health.The prevention and health cares articles such as the effect of seeing market or seeing report medicated toothpaste, mouthwash, mouth sprays or chewing gum
It is mostly that fresh breath, nursing gum, improvement oral environment have certain effect, just do not have work for a long time in a short time
With, though existing oral antimicrobial anti-inflammatory product has certain curative effect, and it is mostly malicious secondary containing being easy to produce in its product or formula
Effect or toxic Western medicine or traditional Chinese medicine ingredients, cannot use long.How in the case where guaranteeing to have no toxic side effect, tooth sheet can be allowed
Body healthy and strong product or technology firm and that oral cavity can be allowed to keep hygiene without scorching environment for a long time have not been reported or apply.
Summary of the invention
For the deficiency or defect of existing product and technology, the application is in the condition for not having to tradition tool toxic side effect raw material
Under, the biogenic to tooth and periodontium with nutrition and health care and repair or biochemical class component are subjected to scientific group
Periodontium and oral cavity can have not only been protected with one group of optimization but also strengthening the muscles and bones can promote tooth and periodontium growth, prophylaxis of teeth
Convenient fit is made into the composition of periodontium and the safe multiple-effect of mouth disease, then the certain technology method of use
Oral care health product.
Details are as follows for the technical solution that the application is taken.
A kind of oral health agent of strengthening tooth antibacterial anti-inflammatory, said preparation include dental growth promotor, and periodontal gum is soft
Organize nourishing agent, natural glue and thickener, anti-caries agent, Biological cross-linker, natural antibacterial antiphlogistic and oral health shield
Manage each active component of agent, under preferable case, said preparation further includes preservative, further preferably in the case of, said preparation further includes the present invention
The acceptable safety barrier of preparation or auxiliary material;
The dental growth promotor, including but not limited to hydroxyapatite, calcium phosphate, calcium gluconate, zinc gluconate and
One of or several arbitrary proportion mixtures may be selected in Rhizoma Drynariae extract;
The periodontal gingival soft tissue nourishing agent, including but not limited to collagen, chondroitin sulfate, collagen peptide, it is optional
Select one of or several arbitrary proportion mixtures;
The natural glue and thickener, including but not limited to gelatin, chitosan, hyaluronic acid or/and hyaluronate gather
One of or several arbitrary proportion mixtures may be selected in glutamic acid or/and polyglutamate;
One of which may be selected in the anti-caries agent, including but not limited to mono-fluor phosphate, sodium fluoride, fluosilicic acid and its esters
Or several arbitrary proportion mixtures;
The Biological cross-linker, including but not limited to poly-D-lysine, pectin, eucommia ulmoides extracts, Geniposide may be selected wherein one
Kind or several arbitrary proportion mixtures;
One of which may be selected in the natural antibacterial antiphlogistic, including but not limited to propolis, lactoferrin, lysozyme, tea polyphenols
Or several arbitrary proportion mixtures;
The oral health care agent, including but not limited to amino acids, vitamin and voenzyme class, sugar-acids, glycitols chemical combination
One of or several arbitrary proportion mixtures may be selected in object.
The preservative, should be food grade preservative, including but not limited to potassium sorbate, dehydroactic acid sodium, potassium cinnamate,
One of or several arbitrary proportion mixtures may be selected in glycyrrhizic acid, glycyrrhetate, propionate.
The glycyrrhetate, for arbitrary proportion mixtures one or two kinds of in potassium glycyrrhizana, sodium glycyrrhetate.
The propionate, for arbitrary proportion mixtures one or two kinds of in sodium propionate, calcium propionate.
The acceptable carrier of described preparation or auxiliary material are solvent, cosolvent, stabilizer, excipient, thickener, disintegrating agent
And/or adhesive.
The preparation includes liquid formulation and solid formulation, preferably solid formulation, the more preferably piece in solid-state agent
Agent.In practical application, the Energy and comfort that can according to need and use, using the preparation as base-material, then mixes this Shen
Please the acceptable safety and comfort of preparation carrier or auxiliary material or excipient, convenient be applicable in is made using corresponding preparations technology
Various dosage forms, including but not limited to oral cleansing lotion, edible chewing gum, protein sugar, toothpaste, tooth gel, tooth powder, mouthwash and piece
Agent.
A kind of oral health agent of strengthening tooth antibacterial anti-inflammatory, the oral health agent are solid formulation, and active constituent accounts for system
The percentage of agent gross mass is 0.1-99.90%, surplus:For the acceptable carrier of this preparation or auxiliary material;It is each in active constituent
Composition is in terms of mass fraction, specially:
The dental growth promotor is extracted by hydroxyapatite, calcium phosphate, calcium gluconate, zinc gluconate and the rhizome of davallia
Object is constituted, specifically:
Hydroxyapatite 0.01-20.0, calcium phosphate 0.001-6.0, calcium gluconate 0.01-6.0, zinc gluconate 0.01-
4.0, Rhizoma Drynariae extract 0.001-9.0;
The periodontal gingival soft tissue nourishing agent, is made of, specifically collagen, chondroitin sulfate, collagen peptide:
Collagen 0.001-10.0, chondroitin sulfate 0.01-6.0, collagen peptide 0.001-12.0;
The natural glue and thickener, by gelatin, chitosan, hyaluronic acid or/and hyaluronate, polyglutamic acid or/
It is constituted with polyglutamate, specifically:
Gelatin 0.001-6.0, chitosan 0.001-6.0, the hyaluronic acid of high molecular weight or/and hyaluronate 0.001-5.0,
The hyaluronic acid or/and hyaluronate of the hyaluronic acid or/and hyaluronate 0.001-8.0 of middle-molecular-weihydroxyethyl, low molecular weight
0.001-10.0, the polyglutamic acid of high molecular weight or/and polyglutamate 0.001-4.0, middle-molecular-weihydroxyethyl polyglutamic acid or/and
Polyglutamate 0.001-6.0, the polyglutamic acid of low molecular weight or/and polyglutamate 0.001-12.0;
The anti-caries agent, is made of, specifically mono-fluor phosphate, sodium fluoride, fluosilicic acid and its esters:
Mono-fluor phosphate 0.001-1.0, sodium fluoride 0.001-1.0, fluosilicic acid and its esters 0.001-1.0;
The Biological cross-linker is made of, specifically poly-D-lysine, pectin, eucommia ulmoides extracts, Geniposide:
Poly-D-lysine 0.01-6.0, pectin 0.01-6.0, eucommia ulmoides extracts 0.01-6.0, Geniposide 0.01-6.0;
The natural antibacterial antiphlogistic, is made of, specifically propolis, lactoferrin, lysozyme, tea polyphenols:
Propolis 0.01-5.0, lactoferrin 0.01-6.0, lysozyme 0.01-6.0, tea polyphenols 0.01-6.0;
The oral health care agent is made of, specifically amino acids, vitamin and voenzyme class, sugar-acids, glycitols compound
For:
Tyrosine 0.001-6.0, alanine 0.001-6.0, proline 0.001-12.0, hydroxyproline 0.001-4.0, lysine
0.001-12.0, arginine 0.001-5.0, serine 0.001-5.0, glycine 0.001-9.0, glutamic acid 0.001-1.0, paddy
Glutamine 0.01-8.0;
VB12 0.01-10.0, vitamin D 0.01-6.0;Vitamin V B1 0.01-6.0, vitamin V B2 0.001-1.0, cigarette
Amide 0.01-10.0, VB5 0.01-6.0, VB6 0.01-6.0, niacin 0.01-5.0, Vc 0.01-5.0, Ve 0.001-
1.0;
Biotin 0.001-1.0, Co-Q10 0.001-1.0, Coenzyme I 0.001-2.0, Coenzyme I I 0.001-2.0;
Trehalose 0.01-9.0, allantoin 0.001-2.0;Taurine 0.01-5.0, lactic acid 0.01-5.0, sodium lactate 0.01-
5.0, sodium glutamate 0.01-3.0;Inositol 0.01-6.0;
Xylitol 0.01-10.0, antierythrite 0.01-8.0, oligofructose 0.01-6.0, menthol 0.01-8.0, peppermint oil
0.01-5.0;
The preservative is made of potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, glycyrrhetate and propionate, tool
For body:It is potassium sorbate 0.01-2.0, dehydroactic acid sodium 0.01-2.0, potassium cinnamate 0.01-2.0, glycyrrhizic acid 0.01-1.0, sweet
Oxalates 0.01-3.0, propionate 0.01-2.0.
The optimization formula of oral health agent as a kind of strengthening tooth antibacterial anti-inflammatory, active constituent account for preparation gross mass
Percentage be 1.0-99.0%, surplus:For the acceptable carrier of this preparation or auxiliary material;Each composition is in active constituent with quality
Number meter, specially:
The dental growth promotor is extracted by hydroxyapatite, calcium phosphate, calcium gluconate, zinc gluconate and the rhizome of davallia
Object is constituted, specifically:
Hydroxyapatite 0.1-20.0, calcium phosphate 0.01-6.0, calcium gluconate 0.1-6.0, zinc gluconate 0.01-3.0, bone
Broken benefit extract 0.01-9.0;
The periodontal gingival soft tissue nourishing agent, is made of, specifically collagen, chondroitin sulfate, collagen peptide:
Collagen 0.01-10.0, chondroitin sulfate 0.01-5.0, collagen peptide 0.01-12.0;
The natural glue and thickener, by gelatin, chitosan, hyaluronic acid or/and hyaluronate, polyglutamic acid or/
It is constituted with polyglutamate, specifically:
Gelatin 0.01-6.0, chitosan 0.01-6.0, the hyaluronic acid of high molecular weight or/and hyaluronate 0.01-5.0, in
The hyaluronic acid or/and hyaluronate of the hyaluronic acid or/and hyaluronate 0.01-8.0 of molecular weight, low molecular weight
0.01-10.0, the polyglutamic acid of high molecular weight or/and polyglutamate 0.01-4.0, the polyglutamic acid of middle-molecular-weihydroxyethyl or/and poly-
Glutamate 0.01-6.0, the polyglutamic acid of low molecular weight or/and polyglutamate 0.01-12.0;
The hyaluronic acid of high, normal, basic three kinds of different molecular weight sizes or/and the high molecular weight hyalomitome in hyaluronate
Acid or hyaluronate refer to that molecular weight is greater than 1,800,000 dalton, the molecule of middle molecular weight hyaluronic acid or hyaluronate
Between 1,000,000-1,800,000 dalton, the molecular weight of low molecular weight hyaluronic acid or hyaluronate is less than amount
600,000 dalton;
The polyglutamic acid or/and the high molecular weight polyglutamic in polyglutamate of high, normal, basic three kinds of different molecular weight sizes
Acid or polyglutamate refer to that molecular weight is greater than 00,000 dalton of Isosorbide-5-Nitrae, the molecule of middle molecule polyglutamic acid or polyglutamate
Amount between 600,000-1,200,000 dalton, the molecular weight of low molecular weight polycaprolactone glutamic acid or polyglutamate less than 600,
000 dalton;
The anti-caries agent, is made of, specifically mono-fluor phosphate, sodium fluoride, fluosilicic acid and its esters:
Mono-fluor phosphate 0.01-1.0, sodium fluoride 0.01-1.0, fluosilicic acid and its esters 0.01-1.0;
The Biological cross-linker is made of, specifically poly-D-lysine, pectin, eucommia ulmoides extracts, Geniposide:
Poly-D-lysine 0.01-5.0, pectin 0.01-5.0, eucommia ulmoides extracts 0.01-5.0, Geniposide 0.01-5.0;
The natural antibacterial antiphlogistic, is made of, specifically propolis, lactoferrin, lysozyme, tea polyphenols:
Propolis 0.01-4.0, lactoferrin 0.01-5.0, lysozyme 0.01-5.0, tea polyphenols 0.01-5.0;
The oral health care agent is made of, specifically amino acids, vitamin and voenzyme class, sugar-acids, glycitols compound
For:
Tyrosine 0.01-6.0, alanine 0.01-6.0, proline 0.01-12.0, hydroxyproline 0.01-4.0, lysine
0.01-12.0, arginine 0.01-5.0, serine 0.01-5.0, glycine 0.01-9.0, glutamic acid 0.01-1.0, glutamy
Amine 0.01-7.0;
VB12 0.01-8.0, vitamin D 0.01-5.0;Vitamin V B1 0.01-5.0, vitamin V B2 0.01-1.0, nicotinoyl
Amine 0.01-9.0, VB5 0.01-5.0, VB6 0.01-5.0, niacin 0.01-4.0, Vc 0.01-4.0, Ve 0.01-1.0;
Biotin 0.01-1.0, Co-Q10 0.01-1.0, Coenzyme I 0.01-2.0, Coenzyme I I 0.01-2.0;
Trehalose 0.01-8.0, allantoin 0.01-2.0;Taurine 0.01-4.0, lactic acid 0.01-4.0, sodium lactate 0.01-4.0,
Sodium glutamate 0.01-2.0;Inositol 0.01-5.0;
Xylitol 0.01-9.0, antierythrite 0.01-7.0, oligofructose 0.01-5.0, menthol 0.01-7.0, peppermint oil
0.01-4.0;
The preservative is made of potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, glycyrrhetate and propionate, tool
For body:Potassium sorbate 0.01-1.80, dehydroactic acid sodium 0.01-1.80, potassium cinnamate 0.01-1.80, glycyrrhizic acid 0.01-
0.80, glycyrrhetate 0.01-2.0, propionate 0.01-1.80.
The preparation method of the oral health agent of the strengthening tooth antibacterial anti-inflammatory, specifically comprises the following steps:
(1)Effective ingredient in the oral health agent is divided into 6 groups according to material properties and the convenience of preparation and easy property processed,
It is spare that dosage in formula is weighed respectively, specifically:
Dental growth promotor such as hydroxyapatite, calcium phosphate etc. isGroup, periodontal gingival soft tissue nourishing agent such as collagen,
Chondroitin sulfate, collagen peptide and natural glue and thickener such as gelatin, chitosan etc. areGroup, amino acids
ForGroup, vitamin coenzymes class compound areGroup, Biological cross-linker such as poly-D-lysine, pectin, eucommia ulmoides extracts, capital Buddhist nun
Equality isGroup, Qi Tawei Group, it is spare;
(2)Weighed solid each group compound is carried out to room temperature or low-temperature grinding respectively as needed, it is spare;
(3)The each group component of crushing is successively placed in mixing machine, room temperature or low temperature are uniformly mixed, spare;
(4)By step(3)Routinely solid formulation or liquid is made in preparation technique to the raw material of preparation with scheduling of production according to demand
Preparation.Solid formulation can be added herein described preparation acceptable safe carrier or auxiliary material and sugar-free candy piece or edible is made
Chewing gum or other tablets, liquid formulation then need that a certain amount of acceptable safety of herein described preparation is first added in the feed
Solvent, room temperature or low temperature dissolution, adjust after filtering and impurity removing constant volume pH value to 6.0-8.0 to obtain the final product.
Step(2)(3)(4)Described in room temperature or cryogenic conditions be preferably less than 45 DEG C, again more preferably less than 30 DEG C but
Greater than 15 DEG C.
Step(2)(3)(4)Described in the operating condition that stirs and evenly mixs be preferably two dimension in medical stainless steel mixer
Be mixed, more preferably in glass reactor or 316L stainless steel blender three-dimensional hybrid stirring or vacuum condition under
Emulsifying method is operated.
Preparing above-mentioned each raw material or component used in preparation described herein is to meet state food or health food
Or the specific biogenic substances of the component having no toxic side effect of food additives and nutrition fortifier or the above standard of National Pharmacopeia grade
Food-borne or drug induccd raw material or component.
The theoretical foundation of the application:The application is based on tooth, periodontium structure, chemical component, growth and development and physiology
Metabolic characteristic, molecule and cell composition and oral cavity unique environments, the cause of disease cause of disease and hair of mouth disease such as dental caries, periodontosis etc.
Open up changing rule, both need to protect according to tooth and periodontium, it is also desirable to nutrition, nutrition be conducive to actively protect, nutrition with
Protect the theory laid equal stress on, first screening there is nutrient growth and health-care effect to tooth and periodontium and belong to biogenic or
Biochemical class, food-borne, clear efficacy the intrinsic basic component of bone tissue for being conducive to dental growth and mineralising, cartilaginous tissue
Then intrinsic basic component, the intrinsic basic component of parodontium, gingival cell are aided with again and promote dentale and periodontium growth group
Bioadhesive or crosslinking agent and anti-caries agent point with dentale and periodontium bonding, then be equipped with and can prevent periodontosis and oral cavity
The natural anticorrosion of ulcer is sterilized or bacteriostatic agent, amino acid necessary to finally growing again with upper teeth and periodontal tissue, dimension
The components such as raw element and coenzyme will have nutrition to tooth and periodontium in the case where not having to tradition tool toxic side effect raw material
It assembles one group of optimization with the biogenic of health-care effect or biochemical class component progress science and can promote tooth and periodontium
The composition of growth, strengthening the muscles and bones, and the safe multiple-effect of energy prophylaxis of teeth and periodontium and other mouth diseases, then use one
Fixed technology method is made into convenient and practical oral health care product.
In the prescription of the application oral health care agent in addition to a small number of derivatives for belonging to biological endogenous property or biochemical class component,
Other is biological endogenous property or biochemical class, food-borne, clear efficacy component, wherein some be constitute dentine and
Basis of enamel such as hydroxyapatite, calcium phosphate etc., some are then the masters for constituting periodontal soft tissue ligament and cartilage
Want ingredient such as collagen, chondroitin sulfate, collagen peptide etc., Rhizoma Drynariae extract can promote the regeneration of bone and repair with again
It builds;Gelatin, chitosan are natural glue and thickener;Poly-D-lysine, pectin, eucommia ulmoides extracts, Geniposide are naturally to pacify
Full crosslinking agent;Xylitol, antierythrite, oligofructose, mono-fluor phosphate, sodium fluoride, fluosilicic acid and its esters are then domestic
Generally acknowledged efficient anti-caries agent outside;It is other, it is mostly be tooth body and periodontal and mouth skin and mucomembranous cell requires it is basic at
Point, moreover, most component is all there are many physiology/pharmacological function or effect, such as a variety of amino acid, vitamin and voenzyme,
As Vc, Ve, Vb5, niacin, niacinamide, Coenzyme I, Coenzyme I I, hyaluronic acid, taurine, arginine, lysine, glutamic acid, cream
Acid, lactate, ubiquinone10Etc. the basis for being composition mouth skin tissue and cell or mucous membrane or maintain normal tissue
Carry out biogenic physiologically active ingredient with cell, meanwhile, they also have anti-aging and moisturizing, it is anti-oxidant with mention
The effects of high skin immunity, antiallergy;Trehalose has the function of protecting Skin Cell under adverse circumstance;It is propolis, lactoferrin, molten
Bacterium enzyme, tea polyphenols are then natural antibiotic antiseptics, are conducive to the long-time stability for keeping product and quality and have important physiology
Function.Said components progress science is assembled and optimizes, can be prepared into using certain technology method can prevent and
Tooth and periodontium and other mouth diseases are treated, and can be used for the oral health care agent of normal healthy people.
Compared with traditional oral treatment and health care product or technical method, the application has following features:
(1)Design is unique, and comprehensively, reasonable recipe not only contributes to repair damaged tissues, also provides one for damaged tissues formula
The approach of kind active defense.Prescription design is carried out according to tooth and periodontium structure, chemical component feature, with target administration
Mode is newborn for tooth and periodontium, repair and reconstruction provides required nutrient, then is equipped with and promotes dentale and periodontium growth
The bioadhesive or crosslinking agent that component and dentale and periodontium bond, and dental caries, periodontosis and canker sore can be prevented
Natural anticorrosion sterilization or the auxiliary agents such as bacteriostatic agent, can not only safety nursing oral cavity, moreover it is possible to promote dentale and periodontium to grow
Component effectively with target tissue or cell combination, provide a kind of approach of active defense for damaged tissues;
(2)Compared with traditional oral therapeutic agent, said preparation is free of any pair of human body toxic side effect or harmful ingredient, it is
It is a kind of to provide the targeting preparation of a variety of nutrition, health care, reparation or reconstruction and therapeutic effect for tooth and periodontium;With rush
It into the regeneration of bone, Periodontal ligament and gingival soft tissue, repairs or rebuilds, prevention and treatment dental caries, periodontosis and canker sore etc. are more
Kind function;
(3)The application product is different from the Western medicine of traditional treatment mouth disease or Chinese medicine or oral care product, traditional treatment oral cavity
The Western medicine of disease or the dosage form of Chinese medicine are mostly oral agents or injection, and the dose for reaching lesion significantly reduces, it is difficult to hide liver
" first pass effect ", side effect is more;Traditional oral care health product is long placed in the group in oral cavity general lack of can allow functional component
Side's support, so, effect is similar with conventional dentifrices, and lasting effect is short, can not be to oral cavity real-time guard;The application product does not have not only
There is " first pass effect ", also has the characteristics that " guided missile drug ", belong to target administration mode, either with liquid formulation, or with
Solid formulation buccal tablet or edible chewing gum form are given, and targeting and long-acting can be played, and implement real-time guard to oral cavity
And nourishing;
(4)The preparation method mild condition of the application preparation, simple process, non-environmental-pollution.Since raw material used herein is
Biogenic substances component, it is more sensitive to physical and chemical factors such as high temperature and illumination, so, by process optimization, establishing one kind can be with
The simple process of the application preparation, non-environmental-pollution technical method is prepared at normal temperature or low temperature;It is achieving environmental protection and energy saving.
(5)The effect of the application product existing drug, and have the health care product can be prolonged and repeated edible or used(Existing adjusting
The effect of body function will not also generate any acute, subacute or chronic hazard to human body)Safety.
Specific embodiment
The application is described in detail below with reference to embodiment:
Embodiment l:
The present embodiment provides a kind of oral health agent of strengthening tooth antibacterial anti-inflammatory, which is solid formulation, activity
The percentage that ingredient accounts for preparation gross mass is 49.80%, surplus:For the acceptable carrier of this preparation or auxiliary material;Active constituent
In each composition in terms of mass fraction, specially:
The dental growth promotor is extracted by hydroxyapatite, calcium phosphate, calcium gluconate, zinc gluconate and the rhizome of davallia
Object is constituted, specifically:Hydroxyapatite 10.0, calcium phosphate 3.0, calcium gluconate 3.0, zinc gluconate 2.0, the rhizome of davallia mention
Take object 5.0;
The periodontal gingival soft tissue nourishing agent, is made of, specifically collagen, chondroitin sulfate, collagen peptide:Glue
Former albumen 5.0, chondroitin sulfate 3.0, collagen peptide 6.0;
The natural glue and thickener, by gelatin, chitosan, hyaluronic acid or/and hyaluronate, polyglutamic acid or/
It is constituted with polyglutamate, specifically:Gelatin 3.0, chitosan 3.0, high molecular weight hyaluronic acid or/and hyaluronate
2.0, the hyaluronic acid or/and hyaluronate 4.0 of middle-molecular-weihydroxyethyl, low molecular weight hyaluronic acid or/and hyaluronate
5.0, the polyglutamic acid or/and polyglutamate 2.0 of high molecular weight, middle-molecular-weihydroxyethyl polyglutamic acid or/and polyglutamate
3.0, the polyglutamic acid or/and polyglutamate 6.0 of low molecular weight;
The anti-caries agent, is made of, specifically mono-fluor phosphate, sodium fluoride, prodan:Mono-fluor phosphate 0.5, fluorination
Sodium 0.5, prodan 0.5;
The Biological cross-linker is made of, specifically poly-D-lysine, pectin, eucommia ulmoides extracts, Geniposide:Poly relies ammonia
Sour 3.0, pectin 3.0, eucommia ulmoides extracts 3.0, Geniposide 3.0;
The natural antibacterial antiphlogistic, is made of, specifically propolis, lactoferrin, lysozyme, tea polyphenols:Propolis 2.0, cream
Ferritin 3.0, lysozyme 3.0, tea polyphenols 3.0;
The oral health care agent is made of, specifically amino acids, vitamin and voenzyme class, sugar-acids, glycitols compound
For:
Tyrosine 3.0, alanine 3.0, proline 6.0, hydroxyproline 2.0, lysine 6.0, arginase 12 .0, serine 2.0,
Glycine 4.0, glutamic acid 0.5, glutamine 4.0;
VB12 5.0, vitamin D 3.0;Vitamin V B1 3.0, vitamin V B2 0.5, niacinamide 5.0, VB5 3.0, VB6
3.0, niacin 2.0, Vc 3.0, Ve 0.5;Biotin 0.5, Co-Q10 0.5, Coenzyme I 1.0, Coenzyme I I 1.0;
Trehalose 4.0, allantoin 1.0;Taurine 2.0, lactic acid 2.0, sodium lactate 2.0, sodium glutamate 1.0;Inositol 3.0;
Xylitol 5.0, antierythrite 4.0, oligofructose 3.0, menthol 4.0, peppermint oil 2.0;
The preservative is made of potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, glycyrrhetate and propionate, tool
For body:Potassium sorbate 1.0, dehydroactic acid sodium 1.0, potassium cinnamate 1.0, glycyrrhizic acid 0.5, potassium glycyrrhizana 0.5, Carbenoxolone Sodium
1.5, sodium propionate 1.0, calcium propionate 1.0.
The preparation method of the oral health agent of strengthening tooth antibacterial anti-inflammatory used in the present embodiment, specifically includes following step
Suddenly:
(1)Effective ingredient in the oral health agent is divided into 6 groups according to material properties and the convenience of preparation and easy property processed,
It is spare that dosage in formula is weighed respectively, specifically:
Dental growth promotor such as hydroxyapatite, calcium phosphate etc. isGroup, periodontal gingival soft tissue nourishing agent such as collagen,
Chondroitin sulfate, collagen peptide and natural glue and thickener such as gelatin, chitosan etc. areGroup, amino acids
ForGroup, vitamin coenzymes class compound areGroup, Biological cross-linker such as poly-D-lysine, pectin, eucommia ulmoides extracts, capital Buddhist nun
Equality isGroup, Qi Tawei Group, it is spare;
(2)Weighed solid each group compound is carried out to room temperature or low-temperature grinding respectively as needed, it is spare;
(3)The each group component of crushing is successively placed in mixing machine, room temperature or low temperature are uniformly mixed, spare;
(4)By step(3)Routinely solid formulation is made in preparation technique to the raw material of preparation with scheduling of production according to demand;
Step(2), step(3), step(4)In carry out broken or when dissolving mixing operation, 30 DEG C of operation temperature or so carry out brokenly
Broken or dissolution mixes operation;It is operated simultaneously using the emulsifying mode under vacuum condition, can preferably ensure mixed effect;
Finally, according to above-mentioned processing step, routinely buccal tablet is made in tablet technology of preparing again is that herein described oral cavity is protected
Strong agent.
To the pollutant of 1 batch products prepared by the present embodiment(Heavy metal)It is carried out with safety indexes such as microorganism limitations
Detection, as a result as shown in the following table 1 and 2:
1 skin irritation of table and pollutant(Heavy metal)Testing result
Note:A refers to GB 16740-2014 national food safety standard-health food safety standard;The inspection of items listed by table 1 and 2
Surveying index is executed by the safe standard GB/T 16740-2014 new standard of the health food that can often eat.
2 microbiological indicator of table
The testing result of the safety indexes such as the heavy metal contaminants of the application preparation and microorganism it can be seen from table 1 and 2,
Comply fully with the safe standard GB/T 16740-2014 of health food that can often eat repeatedly.
The Antimicrobial test effect of oral health agent prepared by the present embodiment
The resisting gram-positive bacteria, Gram-negative bacteria of oral health agent prepared by the present embodiment and the experiment in vitro effect of fungi
Fruit is as shown in table 3 below.
Antibacterial activity comparative study result such as the following table 4 institute of oral health agent prepared by the present embodiment and traditional antibacterials
Show.
4 antibacterial activity contrast and experiment of table
Note:A:The application oral health agent;B:Cefoperazone sodium and sulbactam sodium for injection;C:Cefaloridine for injection;D:Celebrating is big
Mycin;E:Fortimicin;F:Lincomycinum
As can be seen from Table 3, the agent of the application oral health can not only resisting gram-positive bacteria, Gram-negative bacteria, there are also very strong
Antifungal activity.Although the test result of table 4 shows that the agent of this oral health resists Escherichia coli and staphylococcus aureus
Bacterium activity is similar to cefoperazone sodium and sulbactam sodium for injection, but its antimycotic activity is that cefoperazone sodium in injection relaxes
What Batan sodium can not be compared, compared with the antibacterials such as Cefradine, gentamicin, fortimicin and lincomycinum, not only its
The excellent effect of resisting gram-positive bacteria, gram sun negative bacterium, and latter against fungi(Saccharomycete)It is living almost without antibacterial
Property, but the oral health agent is to fungi(Saccharomycete)There is good antibacterial activity.
Practical application effect
To verify the application preparation to saprodontia and periodontosis(Gingivitis)With the therapeutic effect of tooth mobility, 198 are selected at random,
Wherein 108 people of male, 90 people of women, the age 6-75 years old, the course of disease -30 years 1 month with light moderate saprodontia or gingivitis or tooth
The mouth disease volunteer that tooth is degenerated or loosened tries out the application buccal tablet.
Usage:It is brushed teeth before falling asleep after gargling with evening after meal, takes a piece of be put into mouth containing change.Dosage:1 piece/times, 1-4 times/
Day, increase and decrease number and dosage can be taken the circumstances into consideration according to hobby, carry out efficacy evaluation after 7-14 days/course for the treatment of, 2 months.
Efficacy assessment standard:Referring to State Food and Drug Administration《New Chinese medicine guideline of clinical investigations》Phase
It is as follows to close standard formulation:Recovery from illness:Inflammatory pain disappears, and tooth switchs to fasten by loosening;It is effective:Illness is substantially reduced or alleviates;
Effectively:Illness is mitigated;In vain:Illness is without improvement or aggravates.
As a result it is:Cure 112(56.6%), effective 78(39.4%), effective 6(3.0%), invalid 2(1.0%),
Total effective rate 99.0%(P<0.01).And found in using the application production process, most patients, buccal tablets agent 1 time is i.e.
It is effective, containing changing 3-5 days, just there is positive effect, continues containing changing 10 days or so, patients with mild condition symptoms disappear substantially, pain
Or malaise symptoms are cured substantially, are had clear improvement containing changing 1 month or so to tooth degeneration or loosening person, are loosened substantially reduced, tooth
Hat is more glossy, more healthy and stronger, achieves ideal effect.
Embodiment 2:
A kind of oral health agent of strengthening tooth antibacterial anti-inflammatory provided by the present embodiment, preparation method substantially with embodiment 1,
Only adjustment member formula is as follows:
The oral health agent is solid formulation, and the percentage that active constituent accounts for preparation gross mass is 0.1%, surplus:For this system
The acceptable carrier of agent or auxiliary material;Each composition is in terms of mass fraction in active constituent, specially:
The dental growth promotor is extracted by hydroxyapatite, calcium phosphate, calcium gluconate, zinc gluconate and the rhizome of davallia
Object is constituted, specifically:Hydroxyapatite 0.01, calcium phosphate 0.001, calcium gluconate 0.01, zinc gluconate 0.01, bone are broken
Mend extract 9.0;
The periodontal gingival soft tissue nourishing agent, is made of, specifically collagen, chondroitin sulfate, collagen peptide:Glue
Former albumen 0.001, chondroitin sulfate 0.01, collagen peptide 0.001;
The natural glue and thickener, by gelatin, chitosan, hyaluronic acid or/and hyaluronate, polyglutamic acid or/
It is constituted with polyglutamate, specifically:Gelatin 0.001, chitosan 0.001, the hyaluronic acid of high molecular weight or/and hyalomitome
Hydrochlorate 0.001, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 0.001, the hyaluronic acid of low molecular weight or/and transparent
Matter hydrochlorate 0.001, the polyglutamic acid of high molecular weight or/and polyglutamate 0.001, the polyglutamic acid of middle-molecular-weihydroxyethyl or/and poly-
Glutamate 0.001, the polyglutamic acid of low molecular weight or/and polyglutamate 0.001;
The anti-caries agent, is made of, specifically mono-fluor phosphate, sodium fluoride, fluosilicic acid:Mono-fluor phosphate 0.001, fluorination
Sodium 0.001, fluosilicic acid 0.001;
The Biological cross-linker is made of, specifically poly-D-lysine, pectin, eucommia ulmoides extracts, Geniposide:Poly relies ammonia
Sour 0.01, pectin 0.01, eucommia ulmoides extracts 0.01, Geniposide 0.01;
The natural antibacterial antiphlogistic, is made of, specifically propolis, lactoferrin, lysozyme, tea polyphenols:Propolis 0.01, cream
Ferritin 0.01, lysozyme 0.01, tea polyphenols 0.01;
The oral health care agent is made of, specifically amino acids, vitamin and voenzyme class, sugar-acids, glycitols compound
For:
Tyrosine 0.001, alanine 0.001, proline 0.001, hydroxyproline 0.001, lysine 0.001, arginine
0.001, serine 0.001, glycine 0.001, glutamic acid 0.001, glutamine 0.01;
VB12 0.01, vitamin D 0.01;Vitamin V B1 0.01, vitamin V B2 0.001, niacinamide 0.01, VB5
0.01, VB6 0.01, niacin 0.01, Vc 0.01, Ve 0.001;Biotin 0.001, Co-Q10 0.001, Coenzyme I
0.001, Coenzyme I I 0.001;
Trehalose 0.01, allantoin 0.001;Taurine 0.01, lactic acid 0.01, sodium lactate 0.01, sodium glutamate 0.01;Inositol
0.01;
Xylitol 0.01, antierythrite 0.01, oligofructose 0.01, menthol 0.01, peppermint oil 0.01;
The preservative is made of potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, glycyrrhetate and propionate, tool
For body:It is potassium sorbate 0.01, dehydroactic acid sodium 0.01, potassium cinnamate 0.01, glycyrrhizic acid 0.01, potassium glycyrrhizana 0.01, sweet
Sodium oxalate 0.01, sodium propionate 0.01, calcium propionate 0.01.
Finally, it is herein described oral health agent that routinely chewable tablet, which is made, in tablet technology of preparing.
Embodiment 3:
A kind of oral health agent of strengthening tooth antibacterial anti-inflammatory provided by the present embodiment, preparation method substantially with embodiment 1,
Only adjustment member formula is as follows:
The oral health agent is solid formulation, and the percentage that active constituent accounts for preparation gross mass is 99.90%, surplus:For this
The acceptable carrier of preparation or auxiliary material;Each composition is in terms of mass fraction in active constituent, specially:
The dental growth promotor is extracted by hydroxyapatite, calcium phosphate, calcium gluconate, zinc gluconate and the rhizome of davallia
Object is constituted, specifically:Hydroxyapatite 20.0, calcium phosphate 6.0, calcium gluconate 6.0, zinc gluconate 4.0, the rhizome of davallia mention
Take object 0.001;
The periodontal gingival soft tissue nourishing agent, is made of, specifically collagen, chondroitin sulfate, collagen peptide:Glue
Former protein 10 .0, chondroitin sulfate 6.0, collagen peptide 12.0;
The natural glue and thickener, by gelatin, chitosan, hyaluronic acid or/and hyaluronate, polyglutamic acid or/
It is constituted with polyglutamate, specifically:Gelatin 6.0, chitosan 6.0, high molecular weight hyaluronic acid or/and hyaluronate
5.0, the hyaluronic acid or/and hyaluronate 8.0 of middle-molecular-weihydroxyethyl, low molecular weight hyaluronic acid or/and hyaluronate
10.0, the polyglutamic acid or/and polyglutamate 4.0 of high molecular weight, middle-molecular-weihydroxyethyl polyglutamic acid or/and polyglutamate
6.0, the polyglutamic acid or/and polyglutamate 12.0 of low molecular weight;
The anti-caries agent, is made of, specifically mono-fluor phosphate, sodium fluoride, prodan:Mono-fluor phosphate 1.0, fluorination
Sodium 1.0, prodan 1.0;
The Biological cross-linker is made of, specifically poly-D-lysine, pectin, eucommia ulmoides extracts, Geniposide:Poly relies ammonia
Sour 6.0, pectin 6.0, eucommia ulmoides extracts 6.0, Geniposide 6.0;
The natural antibacterial antiphlogistic, is made of, specifically propolis, lactoferrin, lysozyme, tea polyphenols:Propolis 5.0, cream
Ferritin 6.0, lysozyme 6.0, tea polyphenols 6.0;
The oral health care agent is made of, specifically amino acids, vitamin and voenzyme class, sugar-acids, glycitols compound
For:
Tyrosine 6.0, alanine 6.0, proline 12.0, hydroxyproline 4.0, lysine 12.0, arginine 5.0, serine
5.0, glycine 9.0, glutamic acid 1.0, glutamine 8.0;
VB1210.0, vitamin D 6.0;Vitamin V B1 6.0, vitamin V B2 1.0, niacinamide 10.0, VB5 6.0, VB6
6.0, niacin 5.0, Vc 5.0, Ve 1.0;Biotin 1.0, Co-Q10 1.0, Coenzyme I 2.0, Coenzyme I I 2.0;
Trehalose 9.0, allantoin 2.0;Taurine 5.0, lactic acid 5.0, sodium lactate 5.0, sodium glutamate 3.0;Inositol 6.0;
Xylitol 10.0, antierythrite 8.0, oligofructose 6.0, menthol 8.0, peppermint oil 5.0;
The preservative is made of potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, glycyrrhetate and propionate, tool
For body:Potassium sorbate 2.0, dehydroactic acid sodium 2.0, potassium cinnamate 2.0, glycyrrhizic acid 1.0, potassium glycyrrhizana 2.90, glycyrrhizic acid
Sodium 0.01, sodium propionate 2.0, calcium propionate 0.01.
Finally, it is herein described oral health agent that routinely protein sugar tablet, which is made, in candy technology of preparing.
Embodiment 4:
A kind of oral health agent of strengthening tooth antibacterial anti-inflammatory provided by the present embodiment, preparation method substantially with embodiment 1,
Only adjustment member formula is as follows:
The oral health agent is solid formulation, and the percentage that active constituent accounts for preparation gross mass is 20.0%, surplus:For this system
The acceptable carrier of agent or auxiliary material;Each composition is in terms of mass fraction in active constituent, specially:
The dental growth promotor is extracted by hydroxyapatite, calcium phosphate, calcium gluconate, zinc gluconate and the rhizome of davallia
Object is constituted, specifically:Hydroxyapatite 4.0, calcium phosphate 1.0, calcium gluconate 1.0, zinc gluconate 1.0, the rhizome of davallia mention
Take object 2.0;
The periodontal gingival soft tissue nourishing agent, is made of, specifically collagen, chondroitin sulfate, collagen peptide:Glue
Former albumen 2.0, chondroitin sulfate 1.0, collagen peptide 3.0;
The natural glue and thickener, by gelatin, chitosan, hyaluronic acid or/and hyaluronate, polyglutamic acid or/
It is constituted with polyglutamate, specifically:Gelatin 1.0, chitosan 1.0, high molecular weight hyaluronic acid or/and hyaluronate
1.0, the hyaluronic acid or/and hyaluronate 1.0 of middle-molecular-weihydroxyethyl, low molecular weight hyaluronic acid or/and hyaluronate
2.0, the polyglutamic acid or/and polyglutamate 1.0 of high molecular weight, middle-molecular-weihydroxyethyl polyglutamic acid or/and polyglutamate
1.0, the polyglutamic acid or/and polyglutamate 3.0 of low molecular weight;
The anti-caries agent, is made of, specifically mono-fluor phosphate, sodium fluoride, fluosilicic acid:Mono-fluor phosphate 0.1, sodium fluoride
0.1, fluosilicic acid 0.1;
The Biological cross-linker is made of, specifically poly-D-lysine, pectin, eucommia ulmoides extracts, Geniposide:Poly relies ammonia
Sour 1.0, pectin 1.0, eucommia ulmoides extracts 1.0, Geniposide 1.0;
The natural antibacterial antiphlogistic, is made of, specifically propolis, lactoferrin, lysozyme, tea polyphenols:Propolis 1.0, cream
Ferritin 1.0, lysozyme 1.0, tea polyphenols 1.0;
The oral health care agent is made of, specifically amino acids, vitamin and voenzyme class, sugar-acids, glycitols compound
For:
Tyrosine 1.0, alanine 1.0, proline 3 .0, hydroxyproline 1.0, lysine 3.0, arginine 1.0, serine 1.0,
Glycine 2.0, glutamic acid 0.1, glutamine 1.0;
VB12 2.0, vitamin D 1.0;Vitamin V B1 1.0, vitamin V B2 0.01, niacinamide 2.0, VB5 1.0, VB6
1.0, niacin 1.0, Vc 1.0, Ve 0.1;Biotin 0.01, Co-Q10 0.01, Coenzyme I 0.01, Coenzyme I I 0.01;
Trehalose 2.0, allantoin 0.1;Taurine 1.0, lactic acid 1.0, sodium lactate 1.0, sodium glutamate 0.1;Inositol 1.0;
Xylitol 2.0, antierythrite 1.0, oligofructose 1.0, menthol 1.0, peppermint oil 1.0;
The preservative is made of potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, glycyrrhetate and propionate, tool
For body:Potassium sorbate 0.5, dehydroactic acid sodium 0.5, potassium cinnamate 0.5, glycyrrhizic acid 0.5, potassium glycyrrhizana 0.5, Carbenoxolone Sodium
0.5, sodium propionate 0.5, calcium propionate 0.5.
It is herein described oral health agent that routinely edible chewing gum agent, which is made, in chewing gum technology of preparing.
Embodiment 5:
A kind of oral health agent of strengthening tooth antibacterial anti-inflammatory provided by the present embodiment, preparation method substantially with embodiment 1,
Only adjustment member formula is as follows:
The oral health agent be liquid formulation, adjust pH to 6.0-8.0, active constituent account for preparation gross mass percentage be for
40.0%, surplus:For the acceptable carrier of this preparation or auxiliary material;Each composition is in terms of mass fraction in active constituent, specially:
The dental growth promotor is extracted by hydroxyapatite, calcium phosphate, calcium gluconate, zinc gluconate and the rhizome of davallia
Object is constituted, specifically:Hydroxyapatite 8.0, calcium phosphate 2.0, calcium gluconate 2.0, zinc gluconate 2.0, the rhizome of davallia mention
Take object 4.0;
The periodontal gingival soft tissue nourishing agent, is made of, specifically collagen, chondroitin sulfate, collagen peptide:Glue
Former albumen 4.0, chondroitin sulfate 2.0, collagen peptide 9.0;
The natural glue and thickener, by gelatin, chitosan, hyaluronic acid or/and hyaluronate, polyglutamic acid or/
It is constituted with polyglutamate, specifically:Gelatin 2.0, chitosan 2.0, high molecular weight hyaluronic acid or/and hyaluronate
2.0, the hyaluronic acid or/and hyaluronate 3.0 of middle-molecular-weihydroxyethyl, low molecular weight hyaluronic acid or/and hyaluronate
4.0, the polyglutamic acid or/and polyglutamate 3.0 of high molecular weight, middle-molecular-weihydroxyethyl polyglutamic acid or/and polyglutamate
2.0, the polyglutamic acid or/and polyglutamate 9.0 of low molecular weight;
The anti-caries agent, is made of, specifically mono-fluor phosphate, sodium fluoride, prodan:Mono-fluor phosphate 0.3, fluorination
Sodium 0.3, prodan 0.3;
The Biological cross-linker is made of, specifically poly-D-lysine, pectin, eucommia ulmoides extracts, Geniposide:Poly relies ammonia
Sour 2.0, pectin 2.0, eucommia ulmoides extracts 2.0, Geniposide 2.0;
The natural antibacterial antiphlogistic, is made of, specifically propolis, lactoferrin, lysozyme, tea polyphenols:Propolis 2.0, cream
Ferritin 2.0, lysozyme 2.0, tea polyphenols 2.0;
The oral health care agent is made of, specifically amino acids, vitamin and voenzyme class, sugar-acids, glycitols compound
For:
Tyrosine 2.0, alanine 2.0, proline 9.0, hydroxyproline 3.0, lysine 9.0, arginase 12 .0, serine 2.0,
Glycine 4.0, glutamic acid 0.3, glutamine 3.0;
VB12 4.0, vitamin D 2.0;Vitamin V B1 2.0, vitamin V B2 0.1, niacinamide 4.0, VB5 2.0, VB6
2.0, niacin 2.0, Vc 2.0, Ve 0.2;Biotin 0.2, Co-Q10 0.2, Coenzyme I 0.2, Coenzyme I I 0.2;
Trehalose 2.0, allantoin 0.2;Taurine 2.0, lactic acid 2.0, sodium lactate 2.0, sodium glutamate 2.0;Inositol 2.0;
Xylitol 4.0, antierythrite 3.0, oligofructose 2.0, menthol 3.0, peppermint oil 2.0;
The preservative is made of potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, glycyrrhetate and propionate, tool
For body:Potassium sorbate 0.5, dehydroactic acid sodium 0.5, potassium cinnamate 0.5, glycyrrhizic acid 0.5, potassium glycyrrhizana 0.5, Carbenoxolone Sodium
0.5, sodium propionate 0.5, calcium propionate 0.5.
Embodiment 6:
A kind of oral health agent of strengthening tooth antibacterial anti-inflammatory provided by the present embodiment, preparation method substantially with embodiment 1,
Only adjustment member formula is as follows:
The oral health agent is solid formulation, specially gelling agent, active constituent account for preparation gross mass percentage be for
60.0%, surplus:For the acceptable carrier of this preparation or auxiliary material;Each composition is in terms of mass fraction in active constituent, specially:
The dental growth promotor, is made of, specifically hydroxyapatite, calcium phosphate, zinc gluconate:Hydroxyapatite
12.0, calcium phosphate 4.0, zinc gluconate 3.0;
The periodontal gingival soft tissue nourishing agent, is made of, specifically collagen, chondroitin sulfate:Collagen 6.0,
Chondroitin sulfate 4.0;
The natural glue and thickener are made of, specifically gelatin, chitosan:Gelatin 4.0, chitosan 4.0;
The anti-caries agent, is made of, specifically mono-fluor phosphate, sodium fluoride:Mono-fluor phosphate 0.6, sodium fluoride 0.6;
The Biological cross-linker is made of, specifically poly-D-lysine, pectin:Poly-D-lysine 4.0, pectin 4.0;
The natural antibacterial antiphlogistic, is made of, specifically propolis, lysozyme:Propolis 4.0, lysozyme 4.0;
The oral health care agent is made of, specifically sugar-acids, glycitols compound:
Trehalose 6.0, allantoin 0.9;Taurine 4.0, lactic acid 4.0, sodium lactate 4.0, sodium glutamate 2.0;Inositol 4.0;
Xylitol 6.0, antierythrite 5.0, oligofructose 4.0, menthol 5.0, peppermint oil 4.0;
The preservative is made of, specifically potassium sorbate, dehydroactic acid sodium:Potassium sorbate 0.5, dehydroactic acid sodium 0.5.
Embodiment 7:
A kind of oral health agent of strengthening tooth antibacterial anti-inflammatory provided by the present embodiment, preparation method substantially with embodiment 1,
Only adjustment member formula is as follows:
The oral health agent is solid formulation, specially(Tooth)Paste, active constituent account for preparation gross mass percentage be for
80.0%, surplus:For the acceptable carrier of this preparation or auxiliary material;Each composition is in terms of mass fraction in active constituent, specially:
The dental growth promotor, is made of, specifically hydroxyapatite:Hydroxyapatite 16.0;
The periodontal gingival soft tissue nourishing agent, is made of, specifically collagen:Collagen 8.0;
The natural glue and thickener, are made of chitosan, specifically:Chitosan 5.0;
The anti-caries agent, is made of, specifically mono-fluor phosphate:Mono-fluor phosphate 0.8;
The Biological cross-linker, is made of poly-D-lysine, specifically:Poly-D-lysine 5.0;
The natural antibacterial antiphlogistic, is made of, specifically lysozyme:Lysozyme 5.0;
The oral health care agent, is made of, specifically glycitols compound:
Xylitol 8.0, antierythrite 7.0, oligofructose 5.0;
The preservative, is made of potassium sorbate, specifically:Potassium sorbate 0.2.
The test evaluation method of reference implementation example 1, then select 280 at random the age 20-76 years old, -15 years March of the course of disease is equal,
The different volunteer of periodontosis degree, is arranged 7 groups, and every group of 40 volunteers distinguish mouth prepared by Application Example 1 ~ 7
Chamber health-care agent, is tested.
Usage:It is brushed teeth before falling asleep after gargling with evening after meal, suitable usage is selected according to dosage form difference, or containing change or chewing
Or containing chamber of gargling.Dosage:1 or 5-10ml/ times, 1-4 times/day, increase and decrease number and dosage can be taken the circumstances into consideration according to liking, 7-14 days/
The course for the treatment of carries out efficacy evaluation after 2 months.
The oral health agent effect that statistical result shows prepared by embodiment 1 is best, total effective rate 100.0%(P<
0.05);Oral health agent effect prepared by embodiment 2 is worst, total effective rate 57.5%(P<0.05);It is other to be followed successively by:
The total effective rate of embodiment 7 is 62.5%(P<0.05);
The total effective rate of embodiment 6 is 72.5%(P<0.05);The total effective rate of embodiment 5 is 80.0%(P<0.05);
The total effective rate of embodiment 4 is 87.5%(P<0.05);The total effective rate of embodiment 3 is 95.0%(P<0.05).
In summary and largely result of practical application can be seen that the validity of herein described oral health agent not only with
The type for preparing the active principle of preparation is how many, content height is directly related, very big with dosage form used also relationship.
Embodiment 8
A kind of oral health agent of strengthening tooth antibacterial anti-inflammatory provided by the present embodiment, preparation method substantially with embodiment 1,
Only adjustment member formula is as follows:
The oral health agent is solid formulation, specially tablet, and the percentage that active constituent accounts for preparation gross mass is 40.0%,
Surplus:For the acceptable carrier of this preparation or auxiliary material;Each composition is in terms of mass fraction in active constituent, specially:
The dental growth promotor is extracted by hydroxyapatite, calcium phosphate, calcium gluconate, zinc gluconate and the rhizome of davallia
Object is constituted, specifically:Hydroxyapatite 8.0, calcium phosphate 2.0, calcium gluconate 2.0, zinc gluconate 2.0, the rhizome of davallia mention
Take object 4.0;
The periodontal gingival soft tissue nourishing agent, is made of, specifically collagen, chondroitin sulfate, collagen peptide:Glue
Former albumen 4.0, chondroitin sulfate 2.0, collagen peptide 9.0;
The natural glue and thickener, by gelatin, chitosan, hyaluronic acid or/and hyaluronate, polyglutamic acid or/
It is constituted with polyglutamate, specifically:Gelatin 2.0, chitosan 2.0, high molecular weight hyaluronic acid or/and hyaluronate
2.0, the hyaluronic acid or/and hyaluronate 3.0 of middle-molecular-weihydroxyethyl, low molecular weight hyaluronic acid or/and hyaluronate
4.0, the polyglutamic acid or/and polyglutamate 3.0 of high molecular weight, middle-molecular-weihydroxyethyl polyglutamic acid or/and polyglutamate
2.0, the polyglutamic acid or/and polyglutamate 6.0 of low molecular weight;
The anti-caries agent, is made of, specifically mono-fluor phosphate, sodium fluoride, fluosilicic acid and its esters:Mono-fluor phosphate
0.3, sodium fluoride 0.3, fluosilicate 0.3;
The Biological cross-linker is made of, specifically poly-D-lysine, pectin, eucommia ulmoides extracts, Geniposide:Poly relies ammonia
Sour 2.0, pectin 2.0, eucommia ulmoides extracts 2.0, Geniposide 2.0;
The natural antibacterial antiphlogistic, is made of, specifically propolis, lactoferrin, lysozyme, tea polyphenols:Propolis 2.0, cream
Ferritin 2.0, lysozyme 2.0, tea polyphenols 2.0;
The oral health care agent is made of, specifically amino acids, vitamin and voenzyme class, sugar-acids, glycitols compound
For:
Tyrosine 2.0, alanine 2.0, proline 9.0, hydroxyproline 3.0, lysine 9.0, arginase 12 .0, serine 2.0,
Glycine 4.0, glutamic acid 0.3, glutamine 3.0;
VB12 4.0, vitamin D 2.0;Vitamin V B1 2.0, vitamin V B2 0.1, niacinamide 4.0, VB5 2.0, VB6
2.0, niacin 2.0, Vc 2.0, Ve 0.2;
Trehalose 3.0, allantoin 0.2;Taurine 2.0, lactic acid 2.0, sodium lactate 2.0, sodium glutamate 2.0;Inositol 2.0;
Xylitol 4.0, antierythrite 3.0, oligofructose 2.0, menthol 3.0, peppermint oil 2.0;
The preservative is made of potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, glycyrrhetate and propionate, tool
For body:Potassium sorbate 0.5, dehydroactic acid sodium 0.5, sodium propionate 0.5, calcium propionate 0.5.
Embodiment 9
A kind of oral health agent of strengthening tooth antibacterial anti-inflammatory provided by the present embodiment, preparation method substantially with embodiment 1,
Only adjustment member formula is as follows:
The oral health agent is solid formulation, specially tablet, and the percentage that active constituent accounts for preparation gross mass is 40.0%,
Surplus:For the acceptable carrier of this preparation or auxiliary material;Each composition is in terms of mass fraction in active constituent, specially:
The dental growth promotor is extracted by hydroxyapatite, calcium phosphate, calcium gluconate, zinc gluconate and the rhizome of davallia
Object is constituted, specifically:Hydroxyapatite 4.0, calcium phosphate 1.0, calcium gluconate 1.0, zinc gluconate 1.0, the rhizome of davallia mention
Take object 2.0;
The periodontal gingival soft tissue nourishing agent, is made of, specifically collagen, chondroitin sulfate, collagen peptide:Glue
Former albumen 2.0, chondroitin sulfate 1.0, collagen peptide 3.0;
The natural glue and thickener, by gelatin, chitosan, hyaluronic acid or/and hyaluronate, polyglutamic acid or/
It is constituted with polyglutamate, specifically:Gelatin 1.0, chitosan 1.0, high molecular weight hyaluronic acid or/and hyaluronate
1.0, the hyaluronic acid or/and hyaluronate 1.0 of middle-molecular-weihydroxyethyl, low molecular weight hyaluronic acid or/and hyaluronate
2.0, the polyglutamic acid or/and polyglutamate 1.0 of high molecular weight, middle-molecular-weihydroxyethyl polyglutamic acid or/and polyglutamate
1.0, the polyglutamic acid or/and polyglutamate 3.0 of low molecular weight;
The anti-caries agent, is made of, specifically mono-fluor phosphate, sodium fluoride, fluosilicic acid and its esters:Mono-fluor phosphate
0.1, sodium fluoride 0.1, fluosilicate 0.1;
The Biological cross-linker is made of, specifically poly-D-lysine, pectin, eucommia ulmoides extracts, Geniposide:Poly relies ammonia
Sour 1.0, pectin 1.0, eucommia ulmoides extracts 1.0, Geniposide 1.0;
The natural antibacterial antiphlogistic, is made of, specifically propolis, lactoferrin, lysozyme, tea polyphenols:Propolis 1.0, cream
Ferritin 1.0, lysozyme 1.0, tea polyphenols 1.0;
The oral health care agent is made of, specifically amino acids, vitamin and voenzyme class, sugar-acids, glycitols compound
For:
Tyrosine 1.0, alanine 1.0, proline 3 .0, hydroxyproline 1.0, lysine 3.0, arginine 1.0, serine 1.0,
Glycine 2.0, glutamic acid 0.1, glutamine 1.0;
VB12 2.0, vitamin D 1.0;Vitamin V B1 1.0, vitamin V B2 0.01, niacinamide 2.0, VB5 1.0, VB6
1.0, niacin 1.0, Vc 1.0, Ve 0.1;
Trehalose 2.0, allantoin 0.1;Taurine 1.0, lactic acid 1.0, sodium lactate 1.0, sodium glutamate 0.1;Inositol 1.0;
Xylitol 2.0, antierythrite 1.0, oligofructose 1.0, menthol 1.0, peppermint oil 1.0;
The preservative is made of potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, glycyrrhetate and propionate, tool
For body:Potassium sorbate 0.2, dehydroactic acid sodium 0.3, sodium propionate 0.3, calcium propionate 0.2.
The test evaluation method of reference implementation example 1, then select 100 at random the age 20-75 years old, -20 years March of the course of disease is equal,
The different volunteer of periodontosis degree, is arranged 2 groups, and every group of 50 volunteers distinguish mouth prepared by Application Example 8 ~ 9
Chamber health-care agent, is tested.Usage:It is brushed teeth before falling asleep after gargling with evening after meal, containing change or chewable tablet.Dosage:1 piece/times,
1-4 times/day, increase and decrease number and dosage can be taken the circumstances into consideration according to hobby, carry out efficacy evaluation after 7-14 days/course for the treatment of, 2 months.
The preparation effect that statistical result shows prepared by embodiment 8 is best, total effective rate 94.0%(P<0.05), embodiment
The preparation effect of 9 preparations is weaker than embodiment 8, total effective rate 84.0%(P<0.05).
The type of the active principle of herein described oral health agent is identical it can be seen from the above results but content is matched
Than difference, validity also has very big difference.
Comprehensive a large amount of practical application test results, can be with regard to the major advantage of oral health preparation provided herein or beneficial to effect
Fruit sums up as follows:
(1)It can be used for the prevention and treatment and reparation and normal mouth of dental caries caused by many reasons, periodontosis and canker sore
The health maintenance of chamber, it can also be used to which the remineralization and hardening that the fastening of tooth mobility caused by a variety of causes, tooth are degenerated are shunk back
The reparation and nursing of gum.
(2)It is highly-safe, it is widely applicable.The application preparation has no toxic side effect, is non-stimulated, without allergy, is suitable for almost institute
There is crowd.
(3)It is easy to use, excellent effect.The application product not only good effect, quick, but also can be whenever and wherever possible using simultaneously
It can be used for a long time.Unlike traditional drug, there are many limiting factors, also professional are needed to instruct.
(4)The application preparation cannot be only used for the prevention and treatment of dental caries, periodontosis and canker sore, also can be used as general
Logical people's strengthening tooth, strengthening the muscles and bones, the daily health caring articles to keep fit and healthy;Not only the formation of calculus dentalis can have been prevented, but also has been conducive to tooth
The new life and mineralising of essence.
The application is not limited to case study on implementation described above.
Claims (8)
1. a kind of oral health agent of strengthening tooth antibacterial anti-inflammatory, it is characterised in that:Said preparation includes dental growth promotor, tooth
All gingival soft tissue nourishing agents, natural glue and thickener, anti-caries agent, Biological cross-linker, natural antibacterial antiphlogistic and mouth
Chamber health care agent;
The dental growth promotor, including but not limited to hydroxyapatite, calcium phosphate, calcium gluconate, zinc gluconate and
Rhizoma Drynariae extract, selection one of which or several arbitrary proportion mixtures;
The periodontal gingival soft tissue nourishing agent, including but not limited to collagen, chondroitin sulfate, collagen peptide, selection
One of or several arbitrary proportion mixtures;
The natural glue and thickener, including but not limited to gelatin, chitosan, hyaluronic acid or/and hyaluronate gather
Glutamic acid or/and polyglutamate, selection one of which or several arbitrary proportion mixtures;
The anti-caries agent, including but not limited to mono-fluor phosphate, sodium fluoride, fluosilicic acid and its esters, selection it is one of or
Several arbitrary proportion mixtures;
The Biological cross-linker, including but not limited to poly-D-lysine, pectin, eucommia ulmoides extracts, Geniposide, selection are one of
Or several arbitrary proportion mixtures;
The natural antibacterial antiphlogistic, including but not limited to propolis, lactoferrin, lysozyme, tea polyphenols, selection it is one of or
Several arbitrary proportion mixtures;
The oral health care agent, including but not limited to amino acids, vitamin and voenzyme class, sugar-acids, glycitols chemical combination
Object, selection one of which or several arbitrary proportion mixtures.
2. preparation as described in claim 1, it is characterised in that:Said preparation includes preservative;The preservative, including but it is unlimited
In potassium sorbate, dehydroactic acid sodium, potassium cinnamate, glycyrrhizic acid, glycyrrhetate, propionate, selection is one of or several any
Scalemic thereof.
3. preparation as described in claim 1, which is characterized in that said preparation further includes acceptable safety barrier or auxiliary material, institute
It states acceptable safety barrier or auxiliary material is solvent, cosolvent, stabilizer, excipient, thickener, disintegrating agent and/or adhesive.
4. oral health preparation according to claim 1, it is characterised in that:The oral health agent is solid formulation, activity
The percentage that ingredient accounts for preparation gross mass is 0.1-99.90%, surplus:For the acceptable carrier of this preparation or auxiliary material;Activity
Each composition is in terms of mass fraction in ingredient, specially:
The dental growth promotor is extracted by hydroxyapatite, calcium phosphate, calcium gluconate, zinc gluconate and the rhizome of davallia
Object is constituted, specifically:
Hydroxyapatite 0.01-20.0, calcium phosphate 0.001-6.0, calcium gluconate 0.01-6.0, zinc gluconate 0.01-
4.0, Rhizoma Drynariae extract 0.001-9.0;
The periodontal gingival soft tissue nourishing agent, is made of, specifically collagen, chondroitin sulfate, collagen peptide:
Collagen 0.001-10.0, chondroitin sulfate 0.01-6.0, collagen peptide 0.001-12.0;
The natural glue and thickener, by gelatin, chitosan, hyaluronic acid or/and hyaluronate, polyglutamic acid or/
It is constituted with polyglutamate, specifically:
Gelatin 0.001-6.0, chitosan 0.001-6.0, the hyaluronic acid of high molecular weight or/and hyaluronate 0.001-5.0,
The hyaluronic acid or/and hyaluronate of the hyaluronic acid or/and hyaluronate 0.001-8.0 of middle-molecular-weihydroxyethyl, low molecular weight
0.001-10.0, the polyglutamic acid of high molecular weight or/and polyglutamate 0.001-4.0, middle-molecular-weihydroxyethyl polyglutamic acid or/and
Polyglutamate 0.001-6.0, the polyglutamic acid of low molecular weight or/and polyglutamate 0.001-12.0;
The anti-caries agent, is made of, specifically mono-fluor phosphate, sodium fluoride, fluosilicic acid and its esters:
Mono-fluor phosphate 0.001-1.0, sodium fluoride 0.001-1.0, fluosilicic acid and its esters 0.001-1.0;
The Biological cross-linker is made of, specifically poly-D-lysine, pectin, eucommia ulmoides extracts, Geniposide:
Poly-D-lysine 0.01-6.0, pectin 0.01-6.0, eucommia ulmoides extracts 0.01-6.0, Geniposide 0.01-6.0;
The natural antibacterial antiphlogistic, is made of, specifically propolis, lactoferrin, lysozyme, tea polyphenols:
Propolis 0.01-5.0, lactoferrin 0.01-6.0, lysozyme 0.01-6.0, tea polyphenols 0.01-6.0;
The oral health care agent is made of, specifically amino acids, vitamin and voenzyme class, sugar-acids, glycitols compound
For:
Tyrosine 0.001-6.0, alanine 0.001-6.0, proline 0.001-12.0, hydroxyproline 0.001-4.0, lysine
0.001-12.0, arginine 0.001-5.0, serine 0.001-5.0, glycine 0.001-9.0, glutamic acid 0.001-1.0, paddy
Glutamine 0.01-8.0;
VB12 0.01-10.0, vitamin D 0.01-6.0;Vitamin V B1 0.01-6.0, vitamin V B2 0.001-1.0, cigarette
Amide 0.01-10.0, VB5 0.01-6.0, VB6 0.01-6.0, niacin 0.01-5.0, Vc 0.01-5.0, Ve 0.001-
1.0;
Biotin 0.001-1.0, Co-Q10 0.001-1.0, Coenzyme I 0.001-2.0, Coenzyme I I 0.001-2.0;
Trehalose 0.01-9.0, allantoin 0.001-2.0;Taurine 0.01-5.0, lactic acid 0.01-5.0, sodium lactate 0.01-
5.0, sodium glutamate 0.01-3.0;Inositol 0.01-6.0;
Xylitol 0.01-10.0, antierythrite 0.01-8.0, oligofructose 0.01-6.0, menthol 0.01-8.0, peppermint oil
0.01-5.0。
5. preparation according to claim 4, it is characterised in that:The oral health agent is solid formulation, and active constituent accounts for system
The percentage of agent gross mass is 1.0-99.0%, surplus:For the acceptable carrier of this preparation or auxiliary material;In active constituent respectively at
Part is in terms of mass fraction, specially:
The dental growth promotor is extracted by hydroxyapatite, calcium phosphate, calcium gluconate, zinc gluconate and the rhizome of davallia
Object is constituted, specifically:
Hydroxyapatite 0.1-20.0, calcium phosphate 0.01-6.0, calcium gluconate 0.1-6.0, zinc gluconate 0.01-3.0, bone
Broken benefit extract 0.01-9.0;
The periodontal gingival soft tissue nourishing agent, is made of, specifically collagen, chondroitin sulfate, collagen peptide:
Collagen 0.01-10.0, chondroitin sulfate 0.01-5.0, collagen peptide 0.01-12.0;
The natural glue and thickener, by gelatin, chitosan, hyaluronic acid or/and hyaluronate, polyglutamic acid or/
It is constituted with polyglutamate, specifically:
Gelatin 0.01-6.0, chitosan 0.01-6.0, the hyaluronic acid of high molecular weight or/and hyaluronate 0.01-5.0, in
The hyaluronic acid or/and hyaluronate of the hyaluronic acid or/and hyaluronate 0.01-8.0 of molecular weight, low molecular weight
0.01-10.0, the polyglutamic acid of high molecular weight or/and polyglutamate 0.01-4.0, the polyglutamic acid of middle-molecular-weihydroxyethyl or/and poly-
Glutamate 0.01-6.0, the polyglutamic acid of low molecular weight or/and polyglutamate 0.01-12.0;
The anti-caries agent, is made of, specifically mono-fluor phosphate, sodium fluoride, fluosilicic acid and its esters:
Mono-fluor phosphate 0.01-1.0, sodium fluoride 0.01-1.0, fluosilicic acid and its esters 0.01-1.0;
The Biological cross-linker is made of, specifically poly-D-lysine, pectin, eucommia ulmoides extracts, Geniposide:
Poly-D-lysine 0.01-5.0, pectin 0.01-5.0, eucommia ulmoides extracts 0.01-5.0, Geniposide 0.01-5.0;
The natural antibacterial antiphlogistic, is made of, specifically propolis, lactoferrin, lysozyme, tea polyphenols:
Propolis 0.01-4.0, lactoferrin 0.01-5.0, lysozyme 0.01-5.0, tea polyphenols 0.01-5.0;
The oral health care agent is made of, specifically amino acids, vitamin and voenzyme class, sugar-acids, glycitols compound
For:
Tyrosine 0.01-6.0, alanine 0.01-6.0, proline 0.01-12.0, hydroxyproline 0.01-4.0, lysine
0.01-12.0, arginine 0.01-5.0, serine 0.01-5.0, glycine 0.01-9.0, glutamic acid 0.01-1.0, glutamy
Amine 0.01-7.0;
VB12 0.01-8.0, vitamin D 0.01-5.0;Vitamin V B1 0.01-5.0, vitamin V B2 0.01-1.0, nicotinoyl
Amine 0.01-9.0, VB5 0.01-5.0, VB6 0.01-5.0, niacin 0.01-4.0, Vc 0.01-4.0, Ve 0.01-1.0;
Biotin 0.01-1.0, Co-Q10 0.01-1.0, Coenzyme I 0.01-2.0, Coenzyme I I 0.01-2.0;
Trehalose 0.01-8.0, allantoin 0.01-2.0;Taurine 0.01-4.0, lactic acid 0.01-4.0, sodium lactate 0.01-4.0,
Sodium glutamate 0.01-2.0;Inositol 0.01-5.0;
Xylitol 0.01-9.0, antierythrite 0.01-7.0, oligofructose 0.01-5.0, menthol 0.01-7.0, peppermint oil
0.01-4.0。
6. a kind of preparation method of oral health agent according to claim 1, it is characterised in that comprise the steps of:
(1)Effective ingredient in the oral health agent is divided into 6 groups according to material properties and the convenience of preparation and easy property processed,
It is spare that dosage in formula is weighed respectively, specifically:
Dental growth promotor such as hydroxyapatite, calcium phosphate etc. isGroup, periodontal gingival soft tissue nourishing agent such as collagen,
Chondroitin sulfate, collagen peptide and natural glue and thickener such as gelatin, chitosan etc. areGroup, amino acids
ForGroup, vitamin coenzymes class compound areGroup, Biological cross-linker such as poly-D-lysine, pectin, eucommia ulmoides extracts, Geniposide
Etc. forGroup, Qi Tawei Group, it is spare;
(2)Weighed solid each group compound is carried out to room temperature or low-temperature grinding respectively as needed, it is spare;
(3)The each group component of crushing is successively placed in mixing machine, room temperature or low temperature are uniformly mixed, spare;
(4)By step(3)Routinely solid formulation or liquid is made in preparation technique to the raw material of preparation with scheduling of production according to demand
Preparation;
Solid formulation can be added herein described preparation acceptable safe carrier or auxiliary material and sugar-free candy piece or edible is made
Chewing gum or other tablets, liquid formulation then need a certain amount of herein described preparation is first added in the feed acceptable molten
Agent, room temperature or low temperature dissolution, adjust after filtering and impurity removing constant volume pH value to 6.0-8.0 to obtain the final product.
7. the preparation method of oral health agent according to claim 6, it is characterised in that:Step(2), step(3), step
(4)In carry out broken or when dissolving mixing operation, operation temperature is not higher than 45 DEG C, is not less than 15 DEG C;Using three-dimensional mode of averaging or
Emulsifying method under vacuum condition is operated.
8. according to claim 1, oral health agent described in 4 and 5, it is characterised in that:The preparation include liquid formulation and
Solid formulation.
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