CN105213216A - Antibacterial tooth protection collutory of a kind of natural disaccharidase and preparation method thereof - Google Patents
Antibacterial tooth protection collutory of a kind of natural disaccharidase and preparation method thereof Download PDFInfo
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- CN105213216A CN105213216A CN201510732243.9A CN201510732243A CN105213216A CN 105213216 A CN105213216 A CN 105213216A CN 201510732243 A CN201510732243 A CN 201510732243A CN 105213216 A CN105213216 A CN 105213216A
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- collutory
- natural
- disaccharidase
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
The invention discloses antibacterial tooth protection collutory of a kind of natural disaccharidase and preparation method thereof.The active ingredient of this collutory is chitosan and Semen Lini glue, and caries preventive agent is stannous fluoride and xylitol, also comprises wetting agent, inorganic salt, Oleum menthae and purified water.Its preparation method gets purified water, adds chitosan and Semen Lini glue according to quantity, and heating makes dissolving; To be cooled, add caries preventive agent, then add wetting agent, inorganic salt, Oleum menthae, add purified water to full dose, after measuring pH value, obtain product.The present invention has significant antibacterial tooth protection effect.This product, owing to adding wetting agent, can extend the time that oral cavity keeps moistening; Alleviate the pain that patient causes because of xerostomia.Preparation method of the present invention is simple, with low cost, and durable antibacterial effect is effective, to human non-toxic's side effect, and comfortable taste.<!-- 2 -->
Description
Technical field
The invention belongs to medical health product field, particularly antibacterial tooth protection collutory of the natural disaccharidase of one and preparation method thereof.
Background technology
In recent years; the sickness rate of oral pathology is high; along with the raising of living standards of the people and health perception; the control of oral disease and the protection of tooth more and more important; it is inconvenient to there is use in the mouth care means that traditional employing toothpaste is brushed teeth; cleaning not in time, not thoroughly, have the drawbacks such as wearing and tearing to tooth, is difficult to the oral cavity cleaning requirement meeting people.
Oral disease is a kind of common disease, and main manifestations is the symptoms such as gingivitis, dental plaque, oral ulcer, periodontitis, aphtha of the mouth and tongue, halitosis.After the noxious bacteria that oral disease produces enters into blood, on whole body health generation impact in various degree, can even become the Important cause of disease of some general diseases.Modern medicine study shows, oral disease and hormonal system, cardiovascular system respiratory system etc. of unifying all has close relationship.People also prevent the generation of oral disease for a long time by various oral care product.At present, major product in detergents and cosmetic mouth care can be divided into toothpaste, collutory and flavorants, these products mainly play cleaning teeth, tooth-whitening, removal dental plaque, kill the effects such as oral cavity noxious bacteria, caries prevention, fresh breath, also play certain positive role to the treatment of such as some oral diseases such as various focusing depths represented simultaneously.Some other chewing gum as foodstuff, edible implication cleaning sheet etc. also have preventive effect more or less in addition.
Collutory is as a kind of emerging oral cavity cleaning and nursing product, generally be contained in portable Packaging Bottle, can use at any time, thoroughly overcome mouth care not in time, toothpaste uses inconvenient, the clean drawback such as not thorough, the effect such as its cleaning oral cavity, caries prevention and periodontitis is obviously better than conventional toothpaste, and then very popular in recent years.Before the present invention makes, the existing product such as water-soluble chitosan collutory, tea polyphenols collutory uses clinically, but because self fungistatic effect is single, higher to concentration requirement, or need could arrive fungistatic effect with high concentration ethanol synergism, so that narrow antimicrobial spectrum, result of use is poor, mouthfeel is not good, and patient is difficult to the reasons such as acceptance, and causes being difficult to apply.Chinese patent CN102274150 discloses and a kind ofly uses the collutory that chitosan and extractive of flax seed are effective ingredient, utilize the feature that extractive of flax seed retentiveness is strong, improve the mouthfeel of collutory, can extend the time that oral cavity keeps moistening, but this technical scheme can not solve oral antimicrobial and tooth protection two large problems completely.Therefore, good in the urgent need to a kind of retentiveness, can broad-spectrum antiseptic, durable antibacterial effect effectively and have protective effect to tooth, simultaneously also to human non-toxic's side effect, the collutory of comfortable taste.
Stannous fluoride is the professional composition of dentist at clinical life-time service, is the composition that effectively can alleviate gingivitis that U.S. food Drug Administration (FDA) is approved.It has extensive inhibitory action to various types of antibacterial, particularly Periodontal Pathogens, and can continue a few hours.By the generation of anti-bacteria toxic metabolic products (as hydrogen sulfide), stannous fluoride also has certain antagonism to gingivitis reaction.But stannous fluoride is a kind of material of extremely unstable, soluble and oxidation in water, it is said market only has Crest spend 15 years just successfully by stannous fluoride stable components in the middle of toothpaste.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, provide a kind of containing natural antibacterial ingredient, not containing compound essence, retentiveness is good, can broad-spectrum antiseptic, durable antibacterial effect is effective, to human non-toxic's side effect, the collutory of comfortable taste; Meanwhile, the present invention also provides a kind of preparation method of described collutory.
The present invention takes following technical scheme: a kind of natural disaccharidase antimicrobial mouthwash, its active ingredient is chitosan and Semen Lini glue.For obtaining better effect, in described collutory, also comprise wetting agent, inorganic salt, Oleum menthae, caries preventive agent and purified water.Its constituent mass percentage composition is:
Chitosan: 0.1 ~ 1%
Semen Lini glue: 0.1 ~ 1%
Caries preventive agent: 0.05 ~ 0.1%
Wetting agent: 1 ~ 10%
Inorganic salt: 0.5 ~ 1.5%
Oleum menthae: 0.01 ~ 0.05%
Surplus is purified water,
Wherein said caries preventive agent is the mixture of stannous fluoride or stannous fluoride and xylitol.
The preparation method of above-mentioned natural disaccharidase antimicrobial mouthwash, comprises the steps:
(1) Semen Lini glue is joined in dissolution kettle, by purified water swelling 8 ~ 24 hours, then in dissolution kettle, add chitosan, open calorstat, stirring at low speed 0.5 ~ 1 hour at temperature is T=60 ~ 70 DEG C, until chitosan and Semen Lini glue all dissolve, filters and removes impurity;
(2) be 5.0 ~ 6.5 with the pH value of acetic acid regulating step (1) gained solution;
(3) in step (2) gained solution, add caries preventive agent, adjustment temperature is T=30 ~ 40 DEG C, continues to be uniformly mixed;
(4) in step (3) gained solution, add wetting agent, inorganic salt, Oleum menthae, keep temperature to be 30 ~ 40 DEG C, continue to be uniformly mixed;
(5) obtained collutory is delivered to next step operation subpackage, after detection meets product standard, pack, make finished product.
Further, the wetting agent described in above-mentioned preparation method is one or more in sorbitol, glycerol, Polyethylene Glycol, propylene glycol.
Further, the inorganic salt described in above-mentioned preparation method is sodium chloride and calcium chloride mixture, and the mass ratio of sodium chloride and calcium chloride is 2:1.
Beneficial effect of the present invention is as follows:
1. preventing decayed tooth tooth protection effect is remarkable: stannous fluoride easily decomposes and oxidation in water, but but has good stand-up in gluey system, and this is also the reason that Crest toothpaste successfully can add stannous fluoride.The present invention finds in many experiments, adopt chitosan-Semen Lini glue system, chitosan can adsorb stannous ion, and Semen Lini glue and large quantity of moisture are combined into hydrate, decrease the chance that stannous fluoride and hydrone directly react, effectively can retain stannous ion, for avoiding other components, stannous fluoride is had an impact, the present invention finally determines first to make chitosan-Semen Lini glue solution, and adjust ph is 5.0 ~ 6.5, then under lower temperature 30 ~ 40 DEG C of conditions, add the caries preventive agent containing stannous fluoride, hydration material is formed because a large amount of hydrones has been combined with Semen Lini glue, and stannous fluoride is combined with chitosan, because this reducing decomposition and the oxidation of stannous fluoride, the stannous ion retaining 80-100ppm in the final product plays preventing decayed tooth tooth protection effect.
2. natural component, broad-spectrum antiseptic: chitosan of the present invention and Semen Lini glue belong to natural antimicrobial substance, and raw material is extensive, structure is clear and definite, with low cost, and chitosan and Semen Lini glue have Synergistic antimicrobial effect, have excellent fungistatic effect relative to other single chitosan class collutory.
3. comfortable taste: the present invention, owing to adding wetting agent, can extend the time that oral cavity keeps moistening; Alleviate the pain that patient causes because of mouthfeel.
4. safe and effective: preparation method of the present invention is simple, antibacterial tooth protection effect is effective lastingly, to human non-toxic's side effect, and comfortable taste.
Detailed description of the invention
Further illustrate technical scheme of the present invention below by way of specific embodiment, but technical scheme of the present invention is not limited with embodiment.
Embodiment 1:
A preparation method for the antibacterial tooth protection collutory of natural disaccharidase, comprises the steps:
(1) Semen Lini glue of 0.5% is joined in dissolution kettle, by purified water swelling 8 ~ 24 hours, then in dissolution kettle, add the chitosan of 0.5%, open calorstat, stirring at low speed 0.5 ~ 1 hour at temperature is T=60 ~ 70 DEG C, until chitosan and Semen Lini glue all dissolve, filter and remove impurity;
(2) be 5.0 ~ 6.5 with the pH value of acetic acid regulating step (1) gained solution;
(3) in step (2) gained solution, add the stannous fluoride of 0.1%, adjustment temperature is T=30 ~ 40 DEG C, continues to be uniformly mixed;
(4) in step (3) gained solution, add sorbitol, the sodium chloride/calcium chloride of 0.5%, the Oleum menthae of 0.01% of 5%, keep temperature to be 30 ~ 40 DEG C, continue to be uniformly mixed;
(5) obtained collutory is delivered to next step operation subpackage, in testing product, stannous ion content is 80 ~ 100ppm, after meeting product standard, packs, makes finished product.
Embodiment 2:
A preparation method for the antibacterial tooth protection collutory of natural disaccharidase, comprises the steps:
(1) Semen Lini glue of 0.5% is joined in dissolution kettle, by purified water swelling 8 ~ 24 hours, then in dissolution kettle, add the chitosan of 1%, open calorstat, stirring at low speed 0.5 ~ 1 hour at temperature is T=60 ~ 70 DEG C, until chitosan and Semen Lini glue all dissolve, filter and remove impurity;
(2) be 5.0 ~ 6.5 with the pH value of acetic acid regulating step (1) gained solution;
(3) in step (2) gained solution, add the stannous fluoride of 0.05% and the xylitol of 0.05%, adjustment temperature is T=30 ~ 40 DEG C, continues to be uniformly mixed;
(4) in step (3) gained solution, add sorbitol, the sodium chloride/calcium chloride of 0.5%, the Oleum menthae of 0.01% of 5%, keep temperature to be 30 ~ 40 DEG C, continue to be uniformly mixed;
(5) obtained collutory is delivered to next step operation subpackage, in testing product, stannous ion content is 80 ~ 100ppm, after meeting product standard, packs, makes finished product.
Clinical test results shows: embodiment product significantly can reduce the bacterial population in oral cavity in Clinical practice process, the growth of anti-bacteria, reduces calcareous stripping in tooth, reduces dental caries incidence rate.The antibacterial tooth protection collutory of natural disaccharidase of the present invention can kill the pathogenic bacterium causing periodontitis, gingivitis, oral ulcer, dental plaque, dental hemorrhage, halitosis fast, tooth protection teeth consolidating, safety non-toxic, non-stimulated, have no side effect, not developing immunity to drugs, is Novel mouth sterilization, sterilizing clean-keeping articles for use.
Above antibacterial tooth protection collutory of the natural disaccharidase of one provided by the present invention and preparation method thereof is described in detail.Set forth principle of the present invention and embodiment herein by detailed description of the invention, above explanation just understands method of the present invention and core concept thereof for helping.It should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention, can also carry out some improvement and modification to the present invention, these improve and modify and also fall in the protection domain of the claims in the present invention.
Claims (4)
1. the antibacterial tooth protection collutory of natural disaccharidase, is characterized in that, its constituent mass percentage composition is:
Chitosan: 0.1 ~ 1%
Semen Lini glue: 0.1 ~ 1%
Caries preventive agent: 0.05 ~ 0.1%
Wetting agent: 1 ~ 10%
Inorganic salt: 0.5 ~ 1.5%
Oleum menthae: 0.01 ~ 0.05%
Surplus is purified water,
Wherein said caries preventive agent is the mixture of stannous fluoride or stannous fluoride and xylitol.
2. a preparation method for the antibacterial tooth protection collutory of natural disaccharidase as above, is characterized in that comprising the steps:
(1) Semen Lini glue is joined in dissolution kettle, by purified water swelling 8 ~ 24 hours, then in dissolution kettle, add chitosan, open calorstat, stirring at low speed 0.5 ~ 1 hour at temperature is T=60 ~ 70 DEG C, until chitosan and Semen Lini glue all dissolve, filters and removes impurity;
(2) be 5.0 ~ 6.5 with the pH value of acetic acid regulating step (1) gained solution;
(3) in step (2) gained solution, add caries preventive agent, adjustment temperature is T=30 ~ 40 DEG C, continues to be uniformly mixed;
(4) in step (3) gained solution, add wetting agent, inorganic salt, Oleum menthae, keep temperature to be 30 ~ 40 DEG C, continue to be uniformly mixed;
(5) obtained collutory is delivered to next step operation subpackage, after detection meets product standard, pack, make finished product.
3. the antibacterial tooth protection collutory of natural disaccharidase according to claim 1, is characterized in that described wetting agent is one or more in sorbitol, glycerol, Polyethylene Glycol, propylene glycol.
4. the antibacterial tooth protection collutory of natural disaccharidase according to claim 1, it is characterized in that described inorganic salt is the mixture of sodium chloride and calcium chloride, and the mass ratio of sodium chloride and calcium chloride is 2:1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510732243.9A CN105213216B (en) | 2015-11-02 | 2015-11-02 | A kind of natural disaccharide antibacterial shield tooth gargle and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510732243.9A CN105213216B (en) | 2015-11-02 | 2015-11-02 | A kind of natural disaccharide antibacterial shield tooth gargle and preparation method thereof |
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| Publication Number | Publication Date |
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| CN105213216A true CN105213216A (en) | 2016-01-06 |
| CN105213216B CN105213216B (en) | 2017-12-08 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106074192A (en) * | 2016-07-01 | 2016-11-09 | 好来化工(中山)有限公司 | Antioxidative oral care composition |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1034130A (en) * | 1988-07-23 | 1989-07-26 | 吴海元 | Child's preventing decayed tooth health gargle and method for making |
| CN102274150A (en) * | 2011-08-12 | 2011-12-14 | 山东赛克赛斯药业科技有限公司 | Gargle for relieving thirsty symptom and preparation method thereof |
| CN102512345A (en) * | 2011-12-28 | 2012-06-27 | 美晨集团股份有限公司 | Natural antibacterial gargle and preparation method thereof |
| CN104434699A (en) * | 2014-12-18 | 2015-03-25 | 东莞市阿比亚能源科技有限公司 | Tooth washing liquid |
-
2015
- 2015-11-02 CN CN201510732243.9A patent/CN105213216B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1034130A (en) * | 1988-07-23 | 1989-07-26 | 吴海元 | Child's preventing decayed tooth health gargle and method for making |
| CN102274150A (en) * | 2011-08-12 | 2011-12-14 | 山东赛克赛斯药业科技有限公司 | Gargle for relieving thirsty symptom and preparation method thereof |
| CN102512345A (en) * | 2011-12-28 | 2012-06-27 | 美晨集团股份有限公司 | Natural antibacterial gargle and preparation method thereof |
| CN104434699A (en) * | 2014-12-18 | 2015-03-25 | 东莞市阿比亚能源科技有限公司 | Tooth washing liquid |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106074192A (en) * | 2016-07-01 | 2016-11-09 | 好来化工(中山)有限公司 | Antioxidative oral care composition |
| CN106074192B (en) * | 2016-07-01 | 2019-08-06 | 好来化工(中山)有限公司 | Oxidation resistant oral care composition |
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| Publication number | Publication date |
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| CN105213216B (en) | 2017-12-08 |
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