CN105920202A - Coenzyme Q10 gum for protecting teeth, strengthening brain and removing odor - Google Patents

Coenzyme Q10 gum for protecting teeth, strengthening brain and removing odor Download PDF

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Publication number
CN105920202A
CN105920202A CN201610194711.6A CN201610194711A CN105920202A CN 105920202 A CN105920202 A CN 105920202A CN 201610194711 A CN201610194711 A CN 201610194711A CN 105920202 A CN105920202 A CN 105920202A
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CN
China
Prior art keywords
vitamin
ubiquinone
gum
gum base
taurine
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CN201610194711.6A
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Chinese (zh)
Inventor
吴铁
唐林志
王建伟
吕思敏
崔燎
丁喜生
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GUANGDONG RUNHE BIOTECHNOLOGY Co Ltd
Guangdong Medical University
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GUANGDONG RUNHE BIOTECHNOLOGY Co Ltd
Guangdong Medical University
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Priority to CN201610194711.6A priority Critical patent/CN105920202A/en
Publication of CN105920202A publication Critical patent/CN105920202A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A61K9/0058—Chewing gums
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid

Abstract

The invention relates to a coenzyme Q10 gum for protecting teeth, strengthening brain and removing odor. The gum can play the effects of protecting teeth, eliminating halitosis, promoting the development of nerve cells, repairing, and strengthening brain on dental caries, gingivitis, periodontitis and other oral diseases. The coenzyme Q10 gum contains tea polyphenols, xylitol, glycyrrhizin, coenzyme Q10, lipoic acid, taurine, almond oil, glucosamine, calcium gluconate, vitamin B1, vitamin B6, vitamin D and menthol. The product has good prevention and treatment effect on dental caries and oral diseases, can relieve inflammation and pain, strengthen brain, strengthen brain, prevent and treat dental caries, gingivitis, periodontitis, oral ulcer and eliminate halitosis. Through preliminary clinical observation, the gum has very satisfied effect, and is a safe and reliable health product.

Description

The coenzyme Q10 chewing gum of one group of tooth protection Fructus Alpiniae Oxyphyllae deodorization
Technical field
The present invention relates to the ubiquinone of one group of tooth protection Fructus Alpiniae Oxyphyllae deodorization10Chewing gum, this chewing gum is to dental caries, gingivitis, periodontitis And the application person such as oral disease can play and take care of one's teeth, eliminate halitosis, promote the growth of neurocyte, repair, there is brain-strengthening The effect of Fructus Alpiniae Oxyphyllae, belongs to the technical field of medical health care product.
Background technology
Dental caries is the disease that human morbidity is high, China's third time oral health epidemiological investigation display in 2005: every 100 5 years old children just have more than in 66 mouths and have dental caries, 35～44 years old middle-aged population in, this ratio rises to 88.1%, 65～the caries prevalence rate then up to 98.4% of 74 years old old people.World Health Organization (WHO) is by arranged side by side to dental caries and tumor, cardiovascular disease For the big keypoint control disease of the mankind three.Dental caries is after sugary food enters oral cavity, through the effect of cariogenic bacteria in dental plaque, and fermentation Produce acid, these acid (mainly lactic acid) from the local intrusion of pressure surface structural weak, the inorganic matter of dissolved destruction tooth and produce.Dental caries Tooth occurs and in evolution, antibacterial plays a major role at dental caries, generally acknowledges that cariogenic bacterial species is a lot, most importantly in the world Some Streptococcus mutans, actinomycetes and lactobacillus.These antibacterials mix with the mucin in saliva and food scraps, It is firmly adhered in dental surface and nest ditch.This binding is called dental plaque or bacterial plaque (dental plaque).In bacterial plaque A large amount of Production by Bacteria acid, cause the enamel surfaces decalcification below bacterial plaque, dissolving.Clinical investigation proves the childhood caries that in oral cavity, bacterial plaque is many Tooth is the most.Food also plays a role in dental caries forming process, containing substantial amounts of carbohydrate and sugar in food, these Material had both supplied antibacterial life and movable energy in bacterial plaque, made glycolysis produce organic acid further through bacterial metabolism effect, and acid is long-term Being trapped in dental surface and nest ditch, make enamel demineralization destroy, followed by some antibacterial makes again proteolytic form cavity, at present Think that sucrose is cariogenic topmost saccharide.If the mineral salts contained in food, main vitamins and trace element, as The deficiencies such as calcium, phosphorus, vitamin B1, D and fluorine, the anti-caries of tooth is the lowest, causes the condition that dental caries is fallen ill.
Ubiquinone10Being a kind of fat-soluble quinones being widely present in human body, also known as ubiquinone, it is as one weight The cofactor wanted, forms ATP in mitochondrial oxidative phosphorylation and plays a crucial role.Additionally, ubiquinone10Also have directly Antioxidation, can remove free radical, and protection cardiovascular system, from free radical damage and strengthening immune system, is repaired impaired Neuron, treats neurodegenerative diseases；Eliminate antibacterial, the virus entered in human body.In recent years, along with going deep into of research, Ubiquinone10Application in oral cavity is paid close attention to by people, ubiquinone10As a kind of antioxidant, can with scavenging activated oxygen, All having preventive and therapeutic action in various degree at gum disease, periodontal disease and mucosal disease, abroad some countries have contained axle enzyme Toothpaste generate and have listed, the gingiva tissue of normal health contains a kind of natural and inherent ubiquinone10, when microbiological attack Pathological changes gingiva tissue may result in ubiquinone10Content is not enough, thus causes the immune defect in gingiva tissue.Therefore, profit Use ubiquinone10Carry out local treat be one safely, conveniently, effective route of administration.As used ubiquinone10Toothpaste, collutory, Only need to suck and gingiva tissue contact number minute, the effect reducing periodontal microbe quantity, improving periodontal situation can be played.
Coenzyme Q10 is as a kind of powerful antioxidant, by direct and radical reaction in human body, or by making vitamin E regenerates, or and vitamin B6In conjunction with, by one's own efforts or the collaborative effect playing antioxidant.Ubiquinone10Also it is that a kind of immunity of organism increases Strong agent, it can increase thymus and the function of spleen, promote lymphopoiesis, enhancing body neutrophil cell, T cell, B cell, NK cell and macrophage kill antibacterial ability, activating complement and alternative pathway, promotion immunoglobulin and the conjunction of specific antibody Become and strengthen mice delayed allergy.Research shows, the generation of periodontal disease, development have with cellular immunization and humoral immunization Relation.The cell oozed out in periodontal disease inflammatory tissue in early days is based on T cell, along with advancing of disease, B cell and plasma cell More and more, under the stimulation of bacterial plaque antigen, the T cell in patients with periodontal disease body can be broken up, rise in value a large amount of sensitization lymphs of formation Cell, thus cause type III allergy and IV type allergy, B cell is divided into plasmablast, and propagation is thin for slurry further Born of the same parents, and synthetic immunoglobulin.In the immunne response of periodontal disease, mainly neutrophilic granulocyte and macrophage and lymph is thin Born of the same parents etc..They by produce enzyme, make the collagen in periodontal ligament decompose, by formed immune complex, and with just close on Normal cell surface combines and causes cell to dissolve, and the most also suppresses the renewal of fibroblastic differentiation and collagen fiber.Lymph In cell, T cell and B cell are responsible for the effect of cellular immunization and humoral immunization respectively.The antigens such as the antibacterial of bacterial plaque, toxin Stimulate and make T cell activation, while T cell division, propagation, secrete multiple lymphokine, promote and inducing macrophage Producing and secrete cytokines, cause vascular permeability to increase, osteoblast activates.Ubiquinone10Gingivitis, periodontal disease are had pre- Prevent and therapeutical effect, in the whole course of disease of gingivitis and periodontitis, the absorption of gingivitis, attachment loss and alveolar bone Main initiation factor is just distributed across all kinds of bacterial plaque microorganisms on gum and under gum.Patients with periodontal disease is all in its immune system mostly During hypofunction, all kinds of pathogenic bacterium have had opportunity, cause pathogenic microorganism pathological tissues field planting, grow and breed. Ubiquinone10It is effective immunostimulant, the immunologic function of body and gingiva and periodontal tissue can be regulated, thus more effectively support Resist and remove the various pathogenic bacterium of periodontal tissue.Ubiquinone10Gum disease is had preventive effect, there are some researches show suffer from gum disease Ubiquinone in the serum of patient10Concentration less than normal person, ubiquinone10Shortage can make gingiva tissue impaired, and gingivitis patients is every It takes ubiquinone10, use three weeks continuously, in terms of the curative effect for the treatment of gingivitis, compared with other several traditional therapies, Ubiquinone10Serve the effect more obviously improving gingivitis.Scholar's research is had to show the generation of patients with periodontitis peripheral blood free radical Showed increased, ubiquinone10As antioxidant, can effective scavenging activated oxygen, improve periodontal tissue's oxidation resistance, strengthen tooth Week organizes the resistance to antibacterial.Ubiquinone10As auxiliary enzyme material unique in human body, although its in vivo content the abundantest, But its content in vivo can gradually decrease with advancing age.Ubiquinone10Content in vivo reduces and miopragia Time, body can show various corresponding disease, then shows as the diseases such as gingivitis, periodontitis, stomatitis, external source in oral cavity Property supplements ubiquinone10Be conducive to the recovery of respiratory chain electronics transformation function, the ability that splicing thread plastochondria generates, maintain structure of mitochondria Integrity, prevent cellular edema, membranolysis.Exogenous ubiquinone10The reduction of succinic acid-cytochrome can also be strengthened Enzymatic activity, oxygen reduction atom, scavenging activated oxygen, timely supplemented with exogenous ubiquinone10Extremely important.
Ubiquinone10Also effective to diseases of oral mucosa and stomatitis, diseases of oral mucosa prevalence is up to 20%, and someone uses coenzyme Q10Associating Vitamains With Minerals Tablets suffers from light-duty recurrent aphtha to 59 and treats, and result shows that light-duty patient is using coenzyme Q10Associating Vitamains With Minerals Tablets carries out whole body therapeutic month and follows up a case by regular visits to half a year, and patient's ulcer intermission is obviously prolonged than before treatment, and ulcer number is bright Aobvious minimizing.Ubiquinone is described10Associating Vitamains With Minerals Tablets has the curative effect extending recurrent aphtha recurrence period.Ubiquinone10Have The effect of enhancing immunity, can improve the immune state of patient；Scavenging activated oxygen, improves oral mucosa microcirculation, promotes thin Born of the same parents' metabolism, repairs damaged cell, can prevent and repair the damage that radical pair oral mucosa causes.Experiment also confirms that ubiquinone10 Microvascular endothelial dysfunction can be improved by suppression capillary endothelium apoptosis.Ubiquinone10Stomatitis is also had certain treatment Effect, ubiquinone10The immunity of patient, scavenging activated oxygen can be regulated, improve oral mucosa microcirculation and hemorheology, change Kind cellular metabolism, repairs damaged cell, plays prevention and repairs the effect of mucosa injury.
Taurine be a kind of be the abundantest free amino acid of content in body, brain, ovary, uterus, heart, liver, Kidney, bone slit, rich content in muscle, blood.Taurine has important protective effect for heart tissue and neurocyte, Main by inhibited apoptosis, stabilizing cell membrane, anti peroxidation of lipid damage, scavenging activated oxygen, regulation Premeabilisation of cells pressure, Maintaining the mechanism such as intracellular calcium homeostasis, play the effect protecting neurocyte and repairing nerve damage, taurine is to nervus centralis System has Nutrition, particularly significant to visual development, neurodevelopment, is the abundantest free amino acid of central nervous system One of, in various animal brains, content of taurine is also that brood is higher than adults, and along with the continuous growth of brain, brain Middle taurine levels is gradually reduced.Taurine breaks up the dendron of Human Fetal Brain Neuron and cell proliferation has obvious facilitation, Taurine lacks and will have a negative impact the normal development of Human Fetal Brain Neuron, and particularly fetus can be led due to depriving of taurine Cause cerebral hypoplasia, it may be possible to taurine affects the growth promoter of neonatal cerebral cortex by activating Glycine Receptors.? Observe that taurine has the promotion growth promoter of human embryo cerebral neuron, proliferation and differentiation and the effect of slow down aging.Also study card Bright taurine plays an important role as neurotrophic factor in human brain growth course, and the interpolation such as taurine can promote The maturation of the auditory brainstem system of premature infant.Ubiquinone10Human body respiration chain plays an important role in proton displacement and electron transmission, Can be as cellular metabolism and Cellular respiration activator, or important antioxidant and nonspecific immunity strengthening agent, oxygen can be promoted Change phosphorylation reaction, the neural biofilm structure integrity of protection, use in conjunction together with taurine, to protection brain, promote to damage The recovery of the neurocyte of wound, can produce and preferably combine curative effect, and this project is taurine and ubiquinone10Constitute jointly chewing gum, By the mastication of Buccodental, it is possible to make taurine and ubiquinone10Rapidly through the mucosa of oral cavity gingiva, enter neurocyte And tissue, give full play to ubiquinone10Protection neural and promote old and feeble neural rehabilitation, play brain-tonifying effect.
Thioctic acid is also that one is present in mitochondrial coenzyme, and oral thioctic acid enters cell in vivo after intestinal absorption, Owing to thioctic acid has fat-soluble and water miscible characteristic concurrently, therefore can go everywhere without any hindrance here at whole body, arrive any one cell area, The comprehensive usefulness of human body is provided, is a kind of to eliminate accelerated ageing and the free radical caused a disease, similar vitaminic material, is uniquely the most double Having fat-soluble and water miscible omnipotent oxygen agent alive, thioctic acid is free radical hunter, is that body cell utilizes saccharide equal energy source material to produce The restricted required nutrient substance of one needed for raw energy, is widely used in the treatment and prevention multiple disease such as heart disease, diabetes. Thioctic acid is having important effect to producing the metabolism of glucose in the cell of energy, mainly allows cell activation, and sulfur is pungent Acid only has a special task in vivo unlike other antioxidant, and it has the vitamin C of 100 times and the antioxygen of E is turned into With, as with internal ubiquinone10Composition compound recipe, can more activate the effect of other antioxidant, and the active force of thioctic acid also than Other antioxidant comes persistently.Thioctic acid is initially the treatment medicine being taken as diabetes, and later application also finds that it has by force Changing the function that liver is movable, for alimentary toxicosis or the removing toxic substances of metal poisoning, thioctic acid also sets up, and improves nerveous system System is degenerated and alzheimer disease, protects health, the oral diseases such as skin maintenance aging resistance etc. acts on, lipoic acid treats periodontitis Curative effect it is verified that, but thioctic acid and ubiquinone10Cooperate together and make chewing gum and there is presently no report.
Glucosamine is the material of the interior synthesis of human body, is the important nutrient forming chondrocyte, generally there is the soft of human body In the joint tissue such as bone, tendon, being the natural tissues composition of healthy articular cartilage, it can stimulate chondrocyte to generate more glue Former albumen, glycoprotein and osamine polysaccharide.In cartilage, the collagen protein of the most new lives of glucamine, glycoprotein and osamine polysaccharide are more Many, absorbent lubricating fluid is the most, and joint softness is the most healthy.Aging along with human body, the synthesis of glucamine Speed cannot catch up with the speed of decomposition, make internal and joint gradually lack glucamine, and then affect the metabolism in joint, The shortage of glucosamine is increasingly severe, and articular cartilage is constantly degenerated and weares and teares, and causes joint injury, arthritis.Supplement ammonia Base glucose can help repair and safeguard cartilage, and can stimulate chondrocyte and growth.Glucosamine is to knee joint degeneration Arthritis, hyperosteogeny, meniscus injury, the therapeutical effect of the diseases such as degenerative lumbar has been confirmed, but to periodontitis, Gingivitis, the curative effect of dental caries etc. it is not yet reported that, we have discovered that, glucamine can promote ubiquinone10Percutaneous absorbtion, With ubiquinone10Form chewing gum together, by the mastication of Buccodental, ubiquinone can be promoted10Rapidly through gingival mucosa, Playing antiinflammatory anti-oxidative stress, glucamine can also be with ubiquinone simultaneously10Combine anti-at oral mucosa and gingiva performance together Scorching effect, by effects such as enhancing human body immunity power to periodontitis, gingivitis, the oral disease such as dental caries play good prevention and Therapeutical effect, also has good health-care effect to tooth gingiva and root of the tooth, also can solve the effects such as antihalitosis well.
Summary of the invention
This project inventors noted that in the disease in tooth and oral cavity internal ubiquinone10Minimizing is an important reason, Oral supplementation ubiquinone10To improving the state of an illness of patient, promote that the rehabilitation of patient is extremely important, meanwhile, ubiquinone10Make mouth fragrant Sugar, allows ubiquinone10Directly chewing by tooth, plays directly effect around tooth, gingiva and oral cavity, and effect should be more Good, the present invention is with ubiquinone10For main component, add taurine, thioctic acid, glucosamine etc. some increase along with the age and The bioactive ingredients that the human body itself constantly reduced exists, adds tea polyphenols etc. and has antibacterial, the functional component of antiinflammatory, and Glycyrrhizin, xylitol etc. some there is sweet taste but the most sugary sweeting agent, to strengthen ubiquinone simultaneously10Tooth protection antihalitosis effect, Due to taurine, the composition such as thioctic acid can strengthen ubiquinone10Neuroprotective, glucosamine can promote ubiquinone10's Percutaneous absorption, makes this product promote nerve growth and rehabilitation especially, takes care of one's teeth and eliminates halitosis aspect effect spy Good, people can be allowed to take care of one's teeth during chew gum, eliminate halitosis, promote the growth of neurocyte, repair, Thus reach the purpose of nourishing the brain and improving intelligence.The present invention proposes the ubiquinone of one group of tooth protection Fructus Alpiniae Oxyphyllae deodorization accordingly10The formula of chewing gum and life Production. art.
The present invention proposes the ubiquinone of one group of tooth protection Fructus Alpiniae Oxyphyllae deodorization10Chewing gum, is characterized in that this formula contains tea polyphenols, wood Sugar alcohol, glycyrrhizin, ubiquinone10, thioctic acid, taurine, almond oil, glucosamine, calcium gluconate, vitamin B1, Vitamin B6, vitamin D and menthol.Ubiquinone10Consumption can take according to the suggestion of the weight of the state of an illness and doctor, take Time add ubiquinone10Chewing gum companion, has well prevention and therapeutical effect to dental caries and oral disease, can be strong with anti-inflammatory analgetic Brain Fructus Alpiniae Oxyphyllae, prevents and treats dental caries, gingivitis, periodontitis, oral ulcer, eliminates halitosis.This chewing gum through clinical preliminary observation, Effect is the most satisfied, is a safe and reliable health promoting product.
Detailed description of the invention:
The following is the specific embodiment of the present invention, technical scheme is done to be described further, but the present invention Protection domain be not limited to these embodiments, every change without departing substantially from present inventive concept or equivalent replacement are included in this Within bright protection domain.
The present invention, with the production method of common chewing gum, selects high-quality chewing gum base, including traditional with natural rubber Glue, Folium Eriobotryae, gelatin and rosin glyceride, Colophonium；Paraffin or microwax；The composition chewing gum base such as lecithin, it is possible to use Zein, modified wheat gluten etc. substitute gum base in conventional chewing gum, and gum base can account for the 20～45% of formula, other compositions Including: tea polyphenols 1.5～10%, xylitol 10～35%, glycyrrhizin 3～9%, ubiquinone100.5～10%, thioctic acid 1～ 10%, taurine 2～10%, almond oil 1～10%, glucosamine 1～10%, calcium gluconate 0.5～10%, dimension is raw Element B10.1～1%, vitamin B60.1～1%, vitamin D 0.00001～0.00005%, menthol 1～5%.Concrete Production method is: 1. take the ubiquinone of formula ratio10It is first dissolved in almond oil；2. the xylitol of formula ratio, glycyrrhizin, sulfur are taken Octanoic acid, taurine, glucosamine, calcium gluconate, menthol, containing ubiquinone10Almond oil add, mix homogeneously, powder Broken machine is pulverized, and crosses 100 mesh sieves, stand-by as dispensing powder；3. take the gum base of formula ratio, put into and 60 DEG C of thermostat water baths soften 0.5 Hour, the gum base of softening and the dosed powder of half are put into kneader mixer kneader half an hour, add second half dosed powder, Continue to mediate, when temperature reduces to 45 DEG C, add tea polyphenols, vitamin B1, vitamin B6Continue kneading homogeneous to color, Put and be cooled to about 35 DEG C at room temperature, be pressed into strip-type, continue cool to room temperature, be trimmed to definite shape, use paraffin paper Packaging,.
Embodiment one
The ubiquinone of tooth protection Fructus Alpiniae Oxyphyllae deodorization10Chewing gum (one) its formula is: gum base 20～45%, tea polyphenols 1.5～10%, Xylitol 10～35%, glycyrrhizin 3～9%, ubiquinone100.5～10%, thioctic acid 1～10%, taurine 2～10%, Almond oil 1～10%, glucosamine 1～10%, calcium gluconate 0.5～10%, vitamin B1 0.1～1%, vitamin B60.1～1%, vitamin D 0.00001～0.00005%, menthol 1～5%；Its production technology is 1. take formula ratio auxiliary Enzyme Q10It is first dissolved in almond oil；2. the xylitol of formula ratio is taken, glycyrrhizin, thioctic acid, taurine, glucosamine, Calcium gluconate, menthol, containing ubiquinone10Almond oil add, mix homogeneously, pulverizer pulverize, cross 100 mesh sieves, as Dispensing powder is stand-by；3. take the gum base of formula ratio, put in 60 DEG C of thermostat water baths and soften 0.5 hour, the gum base and that will soften The dosed powder of half puts into kneader mixer kneader half an hour, adds second half dosed powder, continues to mediate, treat that temperature is reduced to When 45 DEG C, add tea polyphenols, vitamin B1, vitamin B6Continue kneading homogeneous to color, put and be cooled to 35 DEG C of left sides at room temperature The right side, is pressed into strip-type, continues cool to room temperature, is trimmed to definite shape, packs with paraffin paper,.
Embodiment two
The ubiquinone of tooth protection Fructus Alpiniae Oxyphyllae deodorization10Chewing gum (two) its formula is calculated by the volume of production of 1 kilogram, wherein glue Base 250g, tea polyphenols 50g, xylitol 150g, glycyrrhizin 60g, ubiquinone1010g, thioctic acid 20g, taurine 40g, Almond oil 30g, glucosamine 30g, calcium gluconate 20g, vitamin B12g, vitamin B62g, vitamin D 0.5mg, Menthol 20g；Its production technology is 1. to take the ubiquinone of formula ratio10It is first dissolved in almond oil: 2. take the xylitol of formula ratio, Glycyrrhizin, thioctic acid, taurine, glucosamine, calcium gluconate, menthol, containing ubiquinone10Almond oil add, Mix homogeneously, pulverizer is pulverized, and crosses 100 mesh sieves, stand-by as dispensing powder；3. take the gum base of formula ratio, put into 60 DEG C of constant temperature Water-bath softens 0.5 hour, the gum base of softening and the dosed powder of half is put into kneader mixer kneader half an hour, then adds Enter second half dosed powder, continue to mediate, when temperature reduces to 45 DEG C, add tea polyphenols, vitamin B1And vitamin B6, continue Continuous kneading is homogeneous to color, puts and is cooled to about 35 DEG C at room temperature, be pressed into strip-type, continues cool to room temperature, finishing Become definite shape, pack with paraffin paper,.
Embodiment three
The coenzyme Q10 chewing gum companion of tooth protection Fructus Alpiniae Oxyphyllae deodorization: its formula is calculated by the volume of production of 1 kilogram, wherein gum base 250g, Tea polyphenols 50g, xylitol 150g, glycyrrhizin 60g, thioctic acid 20g, taurine 40g, glucosamine 30g, Fructus Vitis viniferae Calciofon 20g, vitamin B12g, vitamin B62g, vitamin D 0.5mg, menthol 20g；Its production technology is 1. to take The xylitol of formula ratio, glycyrrhizin, thioctic acid, taurine, glucosamine, calcium gluconate, menthol, mixing is all Even, pulverizer is pulverized, and crosses 100 mesh sieves, stand-by as dispensing powder.2. take the gum base of formula ratio, put into 60 DEG C of thermostat water baths Middle softening 0.5 hour, puts into the gum base of softening and the dosed powder of half kneader mixer kneader half an hour, adds second half Dosed powder, continues to mediate, and when temperature reduces to 45 DEG C, adds tea polyphenols, vitamin B1, continues kneading homogeneous to color, Put and be cooled to about 35 DEG C at room temperature, be pressed into strip-type, continue cool to room temperature, be trimmed to definite shape, use paraffin paper Packaging,.
Above-mentioned formula, can use different gum base, according to the character feature of gum base, adjusts in the consumption of gum base and formula it The consumption of his composition, can make the chewing gum product of different size, applies for market.

Claims (5)

1. the coenzyme Q10 chewing gum of one group of tooth protection Fructus Alpiniae Oxyphyllae deodorization, is characterized in that this chewing gum formulations contains cattle sulphur Acid, glucosamine, thioctic acid, tea polyphenols, glycyrrhizin.
The ubiquinone of one group of tooth protection Fructus Alpiniae Oxyphyllae deodorization the most as claimed in claim 110Chewing gum, it is characterized in that by under State formula composition: gum base 20～45%, tea polyphenols 1.5～10%, xylitol 10～35%, glycyrrhizin 3～ 9%, ubiquinone100.5～10%, thioctic acid 1～10%, taurine 2～10%, almond oil 1～10%, ammonia Base glucose 1～10%, calcium gluconate 0.5～10%, vitamin B1 0.1～1%, vitamin D 0.01mg～ 0.05mg%, menthol 1～5%；Its production technology is 1. to take the ubiquinone of formula ratio10It is first dissolved in almond oil； 2. the xylitol of formula ratio is taken, glycyrrhizin, thioctic acid, taurine, glucosamine, calcium gluconate, Menthol, containing ubiquinone10Almond oil add, mix homogeneously, pulverizer pulverize, cross 100 mesh sieves, as Dispensing powder is stand-by；3. take the gum base of formula ratio, put in 60 DEG C of thermostat water baths and soften 0.5 hour, by soft The gum base changed and the dosed powder of half put into kneader mixer kneader half an hour, add second half dispensing powder End, continues to mediate, and when temperature reduces to 45 DEG C, adds tea polyphenols, vitamin B1And vitamin B6, continue Continuous kneading is homogeneous to color, puts and is cooled to about 35 DEG C at room temperature, be pressed into strip-type, continues cool to Room temperature, is trimmed to definite shape, packs with paraffin paper,.
The coenzyme Q10 chewing gum of one group of tooth protection Fructus Alpiniae Oxyphyllae deodorization the most as claimed in claim 1, is characterized in that this is joined Side is calculated by the volume of production of 1 kilogram, wherein gum base 250g, tea polyphenols 50g, xylitol 150g, glycyrrhizin Element 60g, coenzyme Q10 10g, thioctic acid 20g, taurine 10g, almond oil 30g, glucosamine 30g, Calcium gluconate 20g, vitamin B12g, vitamin B62g, vitamin D 0.5mg, menthol 20g； Its production technology is 1. to take the ubiquinone of formula ratio10It is first dissolved in almond oil；2. the xylitol of formula ratio is taken, Glycyrrhizin, thioctic acid, taurine, glucosamine, calcium gluconate, menthol, containing ubiquinone10's Almond oil adds, mix homogeneously, and pulverizer is pulverized, and crosses 100 mesh sieves, stand-by as dispensing powder；3. formula is taken The gum base of amount, puts in 60 DEG C of thermostat water baths and softens 0.5 hour, by the gum base softened and the dispensing of half Powder puts into kneader mixer kneader half an hour, adds second half dosed powder, continues to mediate, treat that temperature drops When being 45 DEG C, add tea polyphenols, vitamin B1, continue kneading homogeneous to color, put and be cooled at room temperature About 35 DEG C, it is pressed into strip-type, continues cool to room temperature, be trimmed to definite shape, pack with paraffin paper, ?.
The coenzyme Q10 chewing gum of one group of tooth protection Fructus Alpiniae Oxyphyllae deodorization the most as claimed in claim 1, is characterized in that this is joined Side is calculated by the volume of production of 1 kilogram, wherein gum base 250g, tea polyphenols 50g, xylitol 150g, glycyrrhizin Element 60g, thioctic acid 20g, taurine 40g, glucosamine 30g, calcium gluconate 20g, vitamin B1 2g, vitamin B62g, vitamin D 0.5mg, menthol 20g；Its production technology is 1. to take formula ratio Xylitol, glycyrrhizin, thioctic acid, taurine, glucosamine, calcium gluconate, menthol, mixed Closing uniformly, pulverizer is pulverized, and crosses 100 mesh sieves, stand-by as dispensing powder.2. take the gum base of formula ratio, put into 60 DEG C of thermostat water baths soften 0.5 hour, the gum base of softening and the dosed powder of half are put into kneader Mixer kneader half an hour, add second half dosed powder, continue to mediate, when temperature reduces to 45 DEG C, add Tea polyphenols, vitamin B1, continue kneading homogeneous to color, put and be cooled to about 35 DEG C at room temperature, pressure Make strip-type, continue cool to room temperature, be trimmed to definite shape, pack with paraffin paper,.
5. such as claim 1, the coenzyme Q10 chewing gum of one group of tooth protection Fructus Alpiniae Oxyphyllae deodorization described in 2,3,4, can adopt With different gum base, according to the character feature of gum base, adjust the consumption of other compositions in the consumption of gum base and formula, The chewing gum product of different size can be made, apply for market.
CN201610194711.6A 2016-03-26 2016-03-26 Coenzyme Q10 gum for protecting teeth, strengthening brain and removing odor Pending CN105920202A (en)

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CN106727249A (en) * 2017-02-21 2017-05-31 糖友管家（北京）健康管理有限公司 A kind of mouthwash and preparation method thereof
CN112137992A (en) * 2020-10-09 2020-12-29 上海宣泰生物科技有限公司 Composition for treating periodontitis and application thereof
CN112915084A (en) * 2021-04-13 2021-06-08 陕西医药控股医药研究院有限公司 Pharmaceutical composition for treating senile cutaneous pruritus and external preparation

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106580723A (en) * 2017-02-21 2017-04-26 糖友管家（北京）健康管理有限公司 Toothpaste and preparation method thereof
CN106727249A (en) * 2017-02-21 2017-05-31 糖友管家（北京）健康管理有限公司 A kind of mouthwash and preparation method thereof
CN106727249B (en) * 2017-02-21 2020-12-08 糖友管家（北京）健康管理有限公司 Mouthwash and preparation method thereof
CN112137992A (en) * 2020-10-09 2020-12-29 上海宣泰生物科技有限公司 Composition for treating periodontitis and application thereof
CN112915084A (en) * 2021-04-13 2021-06-08 陕西医药控股医药研究院有限公司 Pharmaceutical composition for treating senile cutaneous pruritus and external preparation

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