CN106727249A - A kind of mouthwash and preparation method thereof - Google Patents
A kind of mouthwash and preparation method thereof Download PDFInfo
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- CN106727249A CN106727249A CN201710092286.4A CN201710092286A CN106727249A CN 106727249 A CN106727249 A CN 106727249A CN 201710092286 A CN201710092286 A CN 201710092286A CN 106727249 A CN106727249 A CN 106727249A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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Abstract
The present invention relates to a kind of mouthwash, mainly including propolis extract, lipoic acid and aloe extract, the mouthwash includes 0.1 10% propolis extract, 0.1 10% lipoic acid and 0.1 30% aloe extract by mass percentage.The present invention is using lipoic acid, three kinds of components of propolis and aloe extract, synergy, can effective antibacterial bacteriostatic, can effectively suppress and remove bacterial plaque, the oral cavities such as halitosis and canker sore can effectively be treated and effectively alleviate bleeding gums, becoming stomatosis lesion for glycosuria has remission effect.
Description
Technical field
The present invention relates to oral care techniques field, and in particular to a kind of mouthwash and preparation method thereof, more particularly to one
Plant and contain mouthwash of propolis extract, lipoic acid and aloe extract and preparation method thereof.
Background technology
In recent years because living standard is improved, diabetic is more and more, and its complication diabetes foot disease also increasingly increases
It is many, diabetes be by endocrine and metabolic disorders disease caused by inherent cause and the long-term collective effect of environmental factor, by
The World Health Organization (WHO) is classified as one of " three is big " killer of the mankind.
It is in progress with diabetic condition, diabetes stomatosis is diabetes middle and advanced stage common complication, and feature is diseases of oral mucosa
Becoming often has dry, thirsty, a visible explosion of vermilion border, gums, the erosion of periglottis and aphtha, carious tooth, gum hyperemia, oedema,
Rotten to the corn, bleeding also generally existing in diabetic, has had a strong impact on the quality of the life of people.
The plant extracts of natural origin has an abundant biological function, such as emulsification, antibacterial, deodorant, hemostasis, anti-
It is scorching, prevent the diseases such as carious tooth and canker sore, it is rationally effective by the vegetable active extract compound use with function above,
Tend to reach unexpected effect.Because between vegetable active molecule have strong synergistic function, two kinds or
Two or more extracts according to certain ratio it is mixed after, sufficiently the biological nature of respective bioactive molecule can be performed to
It is ultimate attainment, reach a kind of single effect incomparable using extract, referred to as synergistic effect.
The A of CN 106176546 disclose a kind of based on the cleaning of chitosan derivatives depth, bacteriostatic tooth protective mouthwash, and this is gargled
Saliva includes by weight ratio：Chitosan derivatives 3%, glycerine 5%, xylitol 1.5%, efficient solubilizing agents 2%, citric acid
0.55%th, sodium citrate 0.3%, malic acid 0.25%, menthol 0.12%, minty note 0.15%, propolis extract 2%, tea
Leaf extract 3.5%, burnt sugar coloring 0.07%, saccharin sodium 0.04%, chlorohexidene 0.2%, Domiphen bromide 0.0003%, it is balance of go from
Sub- water.The mouthwash also has the effect of restraining and sterilizing bacteria, but above-mentioned formula can not be directed to the complication of diabetes stomatosis, and
Oral problem can only slightly be prevented.
It is problem demanding prompt solution that how to find a kind of mouthwash can alleviate the symptom of sugar diabetes stomatosis.
The content of the invention
In order to solve the above technical problems, the invention provides a kind of mouthwash and preparation method thereof, the present invention is pungent using sulphur
Acid, three kinds of components of propolis and aloe extract, synergy, can effective antibacterial bacteriostatic, can effectively suppress and remove bacterial plaque,
The oral cavities such as halitosis and canker sore can effectively be treated and effectively alleviate bleeding gums, becoming stomatosis lesion for glycosuria has remission effect.
It is up to this purpose, present invention employs following technical scheme：
In a first aspect, the invention provides a kind of mouthwash, the mouthwash includes propolis extract, lipoic acid and aloe
Extract.
Propolis extract has the antibacterial effect of anti-inflammatory in the present invention, and the intraoral harmful bacteria of pin can play suppression and make
With.Aloe extract can as a kind of bacteriostatic agent, wherein the barbaloin and aloe polysaccharide that contain, can with detumescence and promoting granulation, repair
Tissue damage, wound healing etc. are acted on, and can promote wound healing, to stomatocace therapeutic effect significantly, are ground
Study carefully and show barbaloin and aloe polysaccharide, also with certain blood sugar reducing function.Lipoic acid can promote oral cavity micro- as a kind of antioxidant
Circulation, reduces bleeding gums, it is possible to prevent the generation of gingivitis.By using between lipoic acid, propolis and aloe extract
Mutually promote, three has played synergy, serve can effective antibacterial bacteriostatic, can effectively suppress and remove bacterial plaque, energy
Bleeding gums are effectively alleviated in the oral cavities such as enough effectively treatment halitosis and canker sores, and becoming stomatosis lesion for glycosuria has remission effect.
In the present invention, the propolis extract and aloe extract are extracted using method well known in the art, no
With propolis extract and aloe extract that extracting method is extracted, mouthwash of the present invention is not resulted in poor in effect
Not, do not influence mouthwash of the invention, those skilled in the art can be extracted according to actual needs, do not do special herein
Limit.
According to the present invention, the mouthwash includes the propolis extract of 0.1-10% by mass percentage, for example, can be
0.1%th, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 1%, 2%, 3%, 4%, 5%, 6%, 7%,
8%th, 9% or 10%, preferably 0.1-3%, the specific point value between more preferably 1%, and above-mentioned numerical value, are limited to a piece
Width and the consideration for simplicity, the present invention specific point value that no longer scope described in exclusive list includes.
According to the present invention, the mouthwash includes the lipoic acid of 0.1-10% by mass percentage, for example, can be
0.1%th, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.8%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%
Or 10%, preferably 0.1-3%, the specific point value between more preferably 1.5%, and above-mentioned numerical value, as space is limited and
For concise consideration, the present invention specific point value that no longer scope described in exclusive list includes.
According to the present invention, the mouthwash includes the aloe extract of 0.1-30% by mass percentage, for example, can be
0.1%th, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 1%, 2%, 3%, 4%, 5%, 6%, 7%,
8%th, 10%, 12%, 13%, 15%, 16%, 18%, 20%, 22%, 23%, 25%, 26%, 28% or 30%, preferably
0.5-10%, the specific point value between more preferably 5%, and above-mentioned numerical value, as space is limited and for concise consideration,
The present invention specific point value that no longer scope described in exclusive list includes.
In the range of the mass percent of the application, this three for lipoic acid, propolis extract and aloe extract in the present invention
A variety of materials can farthest play synergy each other, it is interacted, and becoming stomatosis lesion especially for glycosuria has
It is relieved effect.
According to the present invention, the mouthwash also includes auxiliary material.
Preferably, the auxiliary material is sweetener, solvent, NMF, freshener, solubilized stabilizer, pH adjusting agent or essence
In any one or at least two combination, the preferably combination of solvent, NMF, solubilized stabilizer and pH adjusting agent enters
One step is preferably the combination of sweetener, solvent, NMF, freshener, solubilized stabilizer, pH adjusting agent and essence.
Inventors be surprised to learn that, auxiliary material is added, being capable of synergy, and auxiliary material therein and the lipoic acid, propolis extract
Can be worked in coordination with aloe extract, not only effect strengthen, to it is antibacterial while, can also alleviate glycosuria dialectal switching patient's
Pain, and it is all safe and non-stimulating by various skin tests.
Preferably, described solvent is ethanol.
According to the present invention, the NMF is used to protect mucous membrane of mouth, oral environment is sentenced the state of relative moistening, because
Diabetes stomatosis patient is also often accompanied by dry mouth symptom, and NMF can be very good to alleviate this symptom, and the NMF is mountain
Pears alcohol and/or glycerine, when the mixture that NMF is sorbierite and glycerine, both can be compounded with any ratio.
Preferably, the solubilized stabilizer is PEG-60 rilanit specials, Cremophor RH40, polysorbas20 or tween
In 80 any one or at least two mixture.
According to the present invention, the pH adjusting agent is the conventional pH adjusting agent in this area, can play the examination of pH adjustment effects
Agent is all feasible, and particular determination is not done herein, and sodium acid carbonate is used in the present invention, any one in sodium citrate or citric acid
Kind or at least two mixture are used as pH adjusting agent.
Preferably, the sweetener be in xylitol, saccharin sodium or Aspartame any one or at least two it is mixed
Close.
Preferably, the freshener is menthol, any one in peppermint oil or menthanol lactic acid ester or at least two
Mixture.
Preferably, the essence is Mint Essence, any one in Chinese ilex essence or Green tea essence.
Preferably, the mouthwash includes following raw material by mass percentage：
Wherein, each component percentage composition sum is 100%.
The mass percent of the sweetener is 0.5-20%, for example can be 0.5%, 0.6%, 0.7%, 0.8%,
0.9%th, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%,
17%th, the specific point value between 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25, and above-mentioned numerical value, is limited to a piece
Width and the consideration for simplicity, the present invention specific point value that no longer scope described in exclusive list includes.
The mass percent of the solvent is 5-50%, for example can be 5%, 6%, 7%, 8%, 9%, 10%, 11%,
12%th, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 23%, 25%, 28%, 30%, 32%, 35%,
36%th, the specific point value between 38%, 40%, 42%, 43%, 45%, 48%, 50%, and above-mentioned numerical value, as space is limited and
For concise consideration, the present invention specific point value that no longer scope described in exclusive list includes.
The mass percent of the NMF is 8-40%, for example can be 8%, 9%, 10%, 11%, 12%, 13%,
14%th, 15%, 16%, 17%, 18%, 19%, 20%, 22%, 23%, 24%, 25%, 26%, 28%, 30%, 32%,
33%th, the specific point value between 35%, 36%, 38%, 40%, and above-mentioned numerical value, as space is limited and for concise consideration,
The present invention specific point value that no longer scope described in exclusive list includes.
The mass percent of the freshener is 0.01-1%, for example can be 0.01%, 0.02%, 0.03%,
0.05%th, 0.06%, 0.08%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%,
Specific point value between 1%, and above-mentioned numerical value, as space is limited and for concise consideration, the present invention no longer exclusive list institute
State the specific point value that scope includes.
The mass percent of the solubilized stabilizer is 0.3-5%, for example can be 0.3%, 0.4%, 0.5%,
0.6%th, 0.7%, 0.8%, 0.9%, 1%, 1.2%, 1.5%, 1.8%, 2%, 2.2%, 2.3%, 2.5%, 2.8%,
3%th, between 3.2%, 3.5%, 3.6%, 3.8%, 4%, 4.2%, 4.5%, 4.6%, 4.8%, 5%, and above-mentioned numerical value
Specific point value, as space is limited and for concise consideration, the present invention specific point value that no longer scope described in exclusive list includes.
The mass percent of the pH adjusting agent is 0.3-10%, for example can be 0.3%, 0.4%, 0.5%, 0.6%,
0.7%th, between 0.8%, 0.9%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9% or 10%, and above-mentioned numerical value
Specific point value, as space is limited and for concise consideration, the present invention specific point value that no longer scope described in exclusive list includes.
The mass percent of the essence is 0.1-2%, for example can be 0.1%, 0.2%, 0.3%, 0.4%,
0.5%th, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%,
Specific point value between 1.9% or 2%, and above-mentioned numerical value, as space is limited and for concise consideration, no longer limit of the invention
Enumerate the specific point value that the scope includes.
Preferably, the mouthwash includes following raw material by mass percentage：
Wherein, each component percentage composition sum is 100%.
Used as optimal technical solution, the mouthwash includes following raw material by mass percentage：
On the other hand, the present invention provides a kind of preparation method of mouthwash as described in relation to the first aspect, comprises the following steps：
(1) sweetener, aloe vera extract are added to and dissolving is stirred until homogeneous in deionized water, add moisturizing
Agent stirs, and forms the aqueous solution of clear；
(2) essence is added in solubilized stabilizer, is well mixed, be subsequently adding propolis extract and stir, formed
The finely dispersed oily solution of dark brown；
(3) dissolving is stirred until homogeneous in lipoic acid and freshener being added into ethanol, as clear as crystal solution is formed；
(4) oily solution of step (2) is added in the solution of step (3), is stirred, form transparent limpid brown
Oily solution；
(5) oily solution that step (4) is obtained is slowly added in the aqueous solution of step (1), is stirred while adding,
Stirring is until be formed uniformly as clear as crystal solution, regulation pH stands overnight, and is processed through filtration sterilization and obtains finished product.
Preferably, the regulation pH described in step (5) is addition pH adjusting agent.
Preferably, the regulation pH to pH is 3-7, for example can be 3,3.1,3.2,3.3,3.5,3.6,3.7,3.8,
3.9th, 4,4.2,4.3,4.5,4.6,4.8,5,5.2,5.3,5.5,5.6,5.8,6,6.2,6.3,6.5,6.8,7, preferably 4-
Specific point value between 6, and above-mentioned numerical value, as space is limited and for concise consideration, described in no longer exclusive list of the invention
The specific point value that scope includes.
In the present invention, the mouthwash for preparing is the transparent settled solution of yellow or brown.
Compared with prior art, the present invention at least has the advantages that：
(1) mouthwash lipoic acid of the present invention, mutually promote between propolis and aloe extract, three has played Synergistic
Effect, for oral cavity can effective antibacterial bacteriostatic, can effectively suppress and remove bacterial plaque, can effectively treat halitosis, oral cavity routed
Effectively alleviate bleeding gums in the oral cavities such as ulcer, additionally it is possible to which becoming stomatosis lesion for glycosuria has remission effect；
(2) mouthwash of the present invention is safe and reliable, and stimulation will not be produced to skin, and long-acting nourishing can while bacteriostasis, and deodorization
To alleviate the pain of glycosuria dialectal switching patient, with double effects, and being capable of long-term use；
(3) preparation method of the present invention is simple, it is easy to operate, low cost, is that base has been established in the marketization beneficial to industrialized production
Plinth.
Specific embodiment
For ease of understanding the present invention, it is as follows that the present invention enumerates embodiment.Those skilled in the art are it will be clearly understood that the implementation
Example is only to aid in understanding the present invention, is not construed as to concrete restriction of the invention.
Embodiment 1
The mouthwash includes following raw material by mass percentage：
The preparation method of the mouthwash comprises the following steps：
(1) sweetener, aloe vera extract are added to and dissolving is stirred until homogeneous in deionized water, add moisturizing
Agent stirs, and forms the aqueous solution of clear；
(2) essence is added in solubilized stabilizer, it is transparent limpid oily solution to be well mixed, and is subsequently adding propolis and carries
Take thing to stir, form the finely dispersed oily solution of dark brown；
(3) dissolving is stirred until homogeneous in lipoic acid and freshener being added into ethanol, as clear as crystal solution is formed；
(4) oily solution of step (2) is added in the solution of step (3), is stirred, form transparent limpid brown
Oily solution；
(5) oily solution that step (4) is obtained is slowly added in the aqueous solution of step (1), is stirred while adding,
Stirring is until be formed uniformly as clear as crystal solution, addition pH adjusting agent adjusts pH to 5, stands overnight, and is processed through filtration sterilization
To finished product.
Preparation method is with embodiment 1.
Embodiment 3
The mouthwash includes following raw material by mass percentage：
Preparation method is with embodiment 1.
Embodiment 4
The mouthwash includes following raw material by mass percentage：
Preparation method is with embodiment 1.
Embodiment 5
The mouthwash includes following raw material by mass percentage：
Preparation method is with embodiment 1.
Comparative example 1
Compared with Example 1, in addition to no propolis extract, lipoic acid and aloe vera extract, other and reality
Apply example 1 identical.
Comparative example 2
Compared with Example 1, in addition to no propolis extract, other are same as Example 1.
Comparative example 3
Compared with Example 1, in addition to no lipoic acid, other are same as Example 1.
Comparative example 4
Compared with Example 1, in addition to no aloe vera extract, other are same as Example 1.
Comparative example 5
Compared with Example 1, in addition to the mass percent of propolis extract is for 15%, other are same as Example 1.
Comparative example 6
Compared with Example 1, in addition to the mass percent of lipoic acid is for 15%, other are same as Example 1.
Comparative example 7
Compared with Example 1, except propolis extract mass percent is that 12%, lipoic acid mass percent is 12%, storehouse
Drag-line aloe extract mass percent be 32% outside, other are same as Example 1.
By embodiment 1-5 and comparative example 1-7 enforcement power considerations, investigate as follows：
(1) bacteriostasis：
Strain：Staphylococcus aureus, Escherichia coli, shigella dysenteriae, Pseudomonas aeruginosa, γ-streptococcus, Candida albicans；
Specific method of testing：The culture medium of each test bacterium is poured into culture dish, after culture medium solidifies completely, with shifting
Supply examination bacteria suspension in culture dish needed for the absorption of liquid rifle, smoothened with spreading rod, take circular filter paper piece and dip mouthwash of the present invention,
Each filter paper is uniformly placed on the culture medium for scribbling bacteria suspension, culture dish sealed membrane sealing, during one section of horizontal inversion culture
Between after, taking-up crossing method measures antibacterial circle diameter, and evaluates bactericidal activity with the presence or absence of inhibition zone and inhibition zone size.
Result of the test is as shown in table 1：
Table 1
As can be seen from Table 1, compared to comparative example 1-7, embodiment 1-5 is by allocating propolis extract, lipoic acid and aloe
The mass fraction of extract, substantially increases fungistatic effect, comparative example 4-5, and embodiment 1-3 is by further carrying propolis
Amount of substance Fractional domination is taken to be controlled in 0.1-3% and aloe extract mass fraction in 0.1-3%, the control of lipoic acid mass fraction
In 0.5-10%, fungistatic effect can be further improved；Can substantially find out from comparative example 1-6, when lipoic acid, propolis extract and
Effect is substantially not so good as embodiment 1-5 when the mass fraction of aloe extract is not in the range of.
(2) clinical observation
Using opinion poll point system, 360 crowd's conducts for having diabetes stomatosis to perplex of 30-70 Sui age bracket are chosen
Object on probation, is arbitrarily divided into 12 groups, and the mouthwash for being prepared with embodiment and comparative example respectively, use time is four months, one
It is with 2 times.
Test result is counted：
Every using effect total score is 5 points：5 points is best result, represents fine, highly effective；4 points is preferable, hence it is evident that effect
Really；3 points is to receive, effective；Less than 3 points for no effect, it is impossible to receives.It is below every average.
Result is as shown in table 2 below：
Table 2
As can be seen from Table 2, compared to comparative example 1-7, embodiment 1-5 is by allocating propolis extract, lipoic acid and aloe
The mass fraction of extract, substantially increase alleviate diabetes stomatosis effect, comparative example 4-5, embodiment 1-3 pass through into
One step controls in 0.1-3%, the control of lipoic acid mass fraction in 0.1-3% and aloe extract propolis extract mass fraction
Mass fraction is controlled in 0.5-10%, can further improve the effect of alleviation；Can substantially find out from comparative example 1-6, when sulphur is pungent
Effect is substantially not so good as embodiment 1-5 when the mass fraction of acid, propolis extract and aloe extract is not in the range of.
Secure data
Anti-inflammatory inhibiting-bacteria preparation of the present invention has preferable anti-inflammatory fungistatic effect after tested, but is necessarily noted in application process
Whether meaning is safe, therefore, make following security test.
1st, multiple (acute) Skin Irritation Test
Reference《Cosmetics safety technical specification (2015 editions)》Multiple (acute) Skin Irritation Test is carried out, is as a result proved：
Lipoic acid 20% and propolis extract 20% and following concentration are safe, non-stimulated.
2nd, mucomembranous irritant test
Mouthwash of the present invention is carried out into oral mucosa, gingival mucosa stimulation test to rabbit and doggie, is as a result proved：This hair
Bright mouthwash to mucous membrane without irritating, also without pathologic lesion.
Experiment confirm anti-inflammatory inhibiting-bacteria preparation of the present invention be it is a kind of it is harmless, nontoxic, have no side effect, non-stimulated safety coefficient it is big
Article.
By above-described embodiment as can be seen that the present invention is using appropriate propolis extract, lipoic acid and aloe extract
Reasonable preparation is carried out, three kinds of component ratios have been have adjusted so that between propolis extract, lipoic acid and aloe extract this three
Synergy is played, the pain of diabetes stomatosis patient can have been alleviated, it is not only safe and non-stimulating with double effects, moreover it is possible to
Enough long-term uses.
Applicant states that the present invention illustrates detailed process equipment of the invention and technological process by above-described embodiment,
But the invention is not limited in above-mentioned detailed process equipment and technological process, that is, do not mean that the present invention has to rely on above-mentioned detailed
Process equipment and technological process could be implemented.Person of ordinary skill in the field it will be clearly understood that any improvement in the present invention,
Addition, the selection of concrete mode to the equivalence replacement and auxiliary element of each raw material of product of the present invention etc., all fall within of the invention
Within the scope of protection domain and disclosure.
Claims (10)
1. a kind of mouthwash, it is characterised in that the mouthwash mainly includes propolis extract, lipoic acid and aloe extract.
2. mouthwash as claimed in claim 1, it is characterised in that the mouthwash is by mass percentage including 0.1-10%
Propolis extract, the lipoic acid of 0.1-10% and 0.1-30% aloe extracts；
Preferably, the mouthwash by mass percentage including the propolis extract of 0.1-3%, the lipoic acid of 0.1-3% and
0.5-10% aloe extracts；
Preferably, the mouthwash includes that 1% propolis extract, 1.5% lipoic acid and 5% aloe carry by mass percentage
Take thing.
3. mouthwash as claimed in claim 1 or 2, it is characterised in that the mouthwash also includes auxiliary material；
Preferably, during the auxiliary material is sweetener, solvent, NMF, freshener, solubilized stabilizer, pH adjusting agent or essence
Any one or at least two combination, the preferably combination of solvent, NMF, solubilized stabilizer and pH adjusting agent, further
The preferably combination of sweetener, solvent, NMF, freshener, solubilized stabilizer, pH adjusting agent and essence.
4. the mouthwash as any one of claim 1-3, it is characterised in that described solvent is ethanol；
Preferably, the NMF is sorbierite and/or glycerine；
Preferably, the solubilized stabilizer is in PEG-60 rilanit specials, Cremophor RH40, polysorbas20 or Tween 80
Any one or at least two mixture；
Preferably, the pH adjusting agent is sodium acid carbonate, in sodium citrate or citric acid any one or at least two it is mixed
Compound.
5. the mouthwash as any one of claim 1-4, it is characterised in that the sweetener is xylitol, saccharin sodium
In Aspartame any one or at least two mixing；
Preferably, the freshener is menthol, in peppermint oil or menthanol lactic acid ester any one or at least two it is mixed
Compound；
Preferably, the essence is Mint Essence, any one in Chinese ilex essence or Green tea essence.
6. the mouthwash as any one of claim 1-5, it is characterised in that the mouthwash includes by mass percentage
Following raw material：
Wherein, each component percentage composition sum is 100%.
7. mouthwash as claimed in claim 6, it is characterised in that the mouthwash includes following raw material by mass percentage：
Wherein, each component percentage composition sum is 100%.
8. mouthwash as claimed in claim 7, it is characterised in that the mouthwash includes following raw material by mass percentage：
9. the preparation method of a kind of mouthwash as described in one of claim 1-8, it is characterised in that comprise the following steps：
(1) sweetener, aloe vera extract are added to and dissolving is stirred until homogeneous in deionized water, added NMF and stir
Mix uniform, form the aqueous solution of clear；
(2) essence is added in solubilized stabilizer, it is transparent limpid oily solution to be well mixed, and is subsequently adding propolis extract
Stir, form the finely dispersed oily solution of dark brown；
(3) dissolving is stirred until homogeneous in lipoic acid and freshener being added into ethanol, as clear as crystal solution is formed；
(4) oily solution of step (2) is added in the solution of step (3), is stirred, form transparent limpid brown oiliness
Solution；
(5) oily solution that step (4) is obtained is slowly added in the aqueous solution of step (1), is stirred while adding, stirred
Until being formed uniformly as clear as crystal solution, pH is adjusted, stood overnight, processed through filtration sterilization and obtain finished product.
10. preparation method as claimed in claim 9, it is characterised in that regulation pH described in step (5) is to add pH regulations
Agent；
Preferably, the regulation pH to pH is 3-7, preferably 4-6.
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| CN106727249B (en) | 2020-12-08 |
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