CN104997660B - A kind of oral cavity composition, preparation method, oral preparation and its application - Google Patents
A kind of oral cavity composition, preparation method, oral preparation and its application Download PDFInfo
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- CN104997660B CN104997660B CN201510433887.8A CN201510433887A CN104997660B CN 104997660 B CN104997660 B CN 104997660B CN 201510433887 A CN201510433887 A CN 201510433887A CN 104997660 B CN104997660 B CN 104997660B
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Abstract
The invention discloses a kind of oral cavity composition, and it is lotion or gelinite, and raw material includes disintegrant, anhydrous NMF, rubbing agent, emulsifying agent, sweetener, binding agent and pH adjusting agent, and the mass fraction of each raw material is：10 30 parts of disintegrant, 10 70 parts of anhydrous NMF, rubbing agent 5 50,0.1 10 parts of emulsifying agent, 0.01 3 parts of sweetener, 0.1 10 parts of binding agent, 1 15 parts of pH adjusting agent.Present invention offer is a kind of to be used in disintegrant the oral cavity composition that in the lotion or gelinite of toothpaste and stability is good.
Description
Technical field
The invention belongs to composition for oral cavity field, and in particular to a kind of to meet water fast reaction, produce a large amount of bubbles
Oral cavity composition, preparation method, oral preparation and its application.
Background technology
At present, people are commonly using the oral care products such as toothpaste, mouthwash cleaning oral cavity and tooth.But daily
Use during, the shortcomings that bad dispersibility occurs in toothpaste when in use, for example, when toothpaste is squeezed in the enterprising entrance cavity brush of toothbrush
During tooth, go out into oral cavity to Tooth paste brush in this period of bubble, it will usually there is a small amount of toothpaste to drop, this phenomenon is tooth
The bad dispersibility of cream.Therefore, someone expects adding the principle of such as effervescent tablet into oral-cavity article, and effervescent tablet is containing effervesce
A kind of tablet of disintegrant, so-called gas-producing disintegrant are typically organic acid and sodium carbonate, sodium acid carbonate (sodium bicarbonate), i.e. bronsted lowry acids and bases bronsted lowry
Mixture；Effervescent tablet dries moisture-free in itself, and two kinds of materials in gas-producing disintegrant are unionized to react；But work as
After effervescent tablet is put into water, two kinds ionize in the presence of water, and metathesis reaction occur, and produce great amount of carbon dioxide, make
Tablet is disintegrated and melted rapidly, and bubble caused by disintegration can also make tablet be rolled up and down in water sometimes, accelerates its disintegration and melts
Change.As can be seen here, disintegrant is used in toothpaste, when toothpaste enters in oral cavity, you can bubble is produced, it is rapid to be disintegrated and melt,
But NMF, essence are usually contained in the lotion of toothpaste or gelinite, and typically each contain moisture in NMF, therefore,
If simply disintegrant is added into existing lotion of toothpaste or in gelinite, because the presence for having moisture occurs in advance
Disintegration and the phenomenon melted, less stable, it can be seen that, disintegrant is used in technological difficulties maximum in oral-cavity article and is
Anhydrous environment is needed, and if after anhydrous in the lotion of toothpaste, then lotion can be caused feeding-up, can not be used.Therefore, it is existing
Have and cleaning tablet of oral cavity is made in disintegrant, for example, the patent of invention that Chinese patent notification number is the A of CN 103479525 discloses
A kind of cleaning tablet of oral cavity and preparation method thereof, this cleaning tablet of oral cavity contain three-decker, and microcapsule layer parcel cleaning agent simultaneously will be clear
Clean dose is sealed in microcapsule layer；Disintegration layer is located at the periphery of microcapsule layer.The application of this tablet is narrower, can not apply in tooth
In the lotion or gelinite of cream.Therefore, the present inventor's research adds disintegrant in the lotion or gelinite of toothpaste,
Research is found, the part material in the lotion or gelinite of toothpaste is changed, and when in disintegrant and lotion or gelinite
Material composition when matching according to a certain percentage, can solve the problems, such as stability difference of the disintegrant in lotion or gelinite.
In addition, the packaging volume of toothpaste is big, it is not readily portable, and use and more bother, need to be first turned on before use
Toothpaste lid, then again extrudes toothpaste to toothbrush；For the people to travel outdoors, brought for trip many
Inconvenience.Therefore, inventor in the course of the study, has found lotion, gelinite can be made into other portable oral cavity systems
Agent, solve the problems, such as that carrying is inconvenient, troublesome in poeration.
The content of the invention
The technical problem to be solved in the present invention provides a kind of that disintegrant is in the lotion or gelinite of toothpaste and steady
Qualitative good oral cavity composition.
In order to solve the above-mentioned technical problem, the present invention provides following technical scheme：A kind of oral cavity composition, its raw material include
Disintegrant, anhydrous NMF, rubbing agent, emulsifying agent, sweetener, binding agent and pH adjusting agent, and the mass fraction of each raw material is：
Disintegrant 10-30 parts, anhydrous NMF 10-70, rubbing agent 5-50 parts, emulsifying agent 0.1-10 parts, sweetener 0.01-3 parts, bonding
Agent 0.1-10 parts, pH adjusting agent 1-15 parts.
Using the oral cavity composition of technical solution of the present invention, anhydrous NMF is the NMF for not containing moisture, generally bag
Glycerine, polyethylene glycol are included, due to not including water in raw material, therefore, avoids disintegrant from being disintegrated and melt in advance, and between each raw material
After said ratio, lotion made from discovery or gelinite stability is good and denseness is easy to use.
Preferably, described disintegrant is made up of bronsted lowry acids and bases bronsted lowry, and each mass fraction is：Sour 4.34~27.27 parts, alkali 5.66
~22.73 parts.One or more of mixtures of the acid in citric acid, tartaric acid, fumaric acid, malic acid；Alkali be selected from sodium carbonate,
One or more of mixtures in sodium acid carbonate, potassium carbonate.
Preferably, raw material also includes essence, and when it is lotion, the mass fraction of each raw material is：5~15 parts of acid, alkali 6~
15 parts, anhydrous NMF 20-50 parts, rubbing agent 15-30 parts, emulsifying agent 0.1-3 parts, sweetener 1.8-2.5 parts, binding agent 0.1-
3 parts, pH adjusting agent 1-15 parts, essence 0.9-1.2 parts.When being matched for more than, manufactured paste stability is good, and denseness most connects
Nearly existing toothpaste denseness, is easy to use.
Preferably, the mass fraction of described each raw material is：7.5 parts of acid, 10 parts of alkali, 45 parts of anhydrous NMF, rubbing agent
25 parts, 1 part of emulsifying agent, 2.0 parts of sweetener, 0.5 part of binding agent, 8 parts of pH adjusting agent, 1 part of essence.
Preferably, raw material also includes essence, and when it is gelinite, the mass fraction of each raw material is：Sour 5~15 parts, alkali
6-15 parts, anhydrous NMF 40-70, rubbing agent 10-15 parts, emulsifying agent 0.5-3 parts, sweetener 1.8-2.5 parts, binding agent 0.1-
3 parts, pH adjusting agent 1-15 parts, essence 0.9-1.2 parts.
Preferably, the mass fraction of described each raw material is：7.5 parts of acid, 7.5 parts of alkali, 60 parts of anhydrous NMF, rubbing agent
15 parts, 1 part of emulsifying agent, 2.0 parts of sweetener, 0.5 part of binding agent, 5.5 parts of pH adjusting agent, 1 part of essence.
It is a further object of the present invention to provide a kind of preparation method of above-mentioned oral cavity composition, preferably to solve stability
The problem of.
The lotion of existing toothpaste either generally can also be containing essence or with certain effect in gelinite composition, example
Such as, the antiallergic factor, the whitening factor；And essence is typically essential oil or the artificial synthesized essence using extracted form natural plant,
It is typically liquid, and therefore, when containing essence in toothpaste, then inevasible that water occurs, research is found, disintegrant meeting
Reacted with water, be disintegrated in advance and melt a small amount of bubble of appearance, but do not influence to use, therefore, in order to solve this problem, inventor
It was found that each raw material can be solved into this problem, stability is still good according to the preparation method of the oral cavity composition of the present invention.
To solve the problems, such as the preparation method of oral cavity composition proposed by the present invention, the present invention provides following technical scheme, its
Operating procedure is as follows：
1) acid, the sweetener in disintegrant are taken, the acid in disintegrant and sweetener are added into anhydrous guarantor simultaneously by stirring
It is well mixed in humectant；
2) rubbing agent, emulsifying agent, binding agent and pH adjusting agent are taken, and is well mixed；
3) after the material mixing obtained by step 1), 2), add in Manufacturing medicine extract machine after stirring, add essence and disintegrant
In alkali, continue to stir, prepare complete.
Above-mentioned steps, because bronsted lowry acids and bases bronsted lowry successively adds in disintegrant, and when being eventually adding essence and alkali, the water in essence
Can the rubbing agent that be added in advance absorb rapidly, so as to avoid bronsted lowry acids and bases bronsted lowry water disintegration and thawing simultaneously, stability is good.
Another object of the present invention be to provide it is a kind of be easy to carry, easy to operate oral preparation.
In order to solve the problems, such as to be easy to carry, the present invention provides following technical scheme：Utilize mouth made of oral cavity composition
Cavity preparations, including capsule, tablet, granule.Lotion is loaded in capsule, capsule is made；It will be dried then after lotion tabletting
Tablet is made；Granule is then made after lotion is pelletized；And gel can be loaded in capsule and capsule is made.Capsule, tablet,
Granule then when outgoing, can be carried directly, in use, only needing to be placed in oral cavity, be occurred with the saliva in oral cavity
Reaction, disintegration and melts, then is used to clean tooth, easy to operate, be easy to carry.
Another object of the present invention is to provide a kind of application of above-mentioned oral preparation so that has a wide range of application.
The present invention provides following technical scheme：Described capsule, tablet, granule are dissolved in liquid and obtain liquid
Dentifrice, Clearer or collutory.In daily life, cleaning tooth is not limited to tooth gel, toothpaste etc., also can use and gargles
Saliva, Clearer or other liquid dentifrices, therefore, the above-mentioned capsule, tablet, granule for being used to clean tooth is dissolved in
In liquid, liquid dentifrice, Clearer or collutory is made, may be such that again on easy to carry, easy to operate basis
The application of above-mentioned oral preparation is wider.
Embodiment
First, oral cavity composition of the present invention, when being lotion, the raw material composition of each embodiment is as shown in table 1, unit g：
Table 1
One~embodiment of embodiment 15, acid, the citric acid of disintegrant in one~comparative example of comparative example eight replace with wine
One or several kinds of mixtures in stone acid, fumaric acid, malic acid, effect are consistent with the effect for adding citric acid；Alkali, bicarbonate
Sodium replaces with one or more of mixtures in sodium carbonate, potassium carbonate, saleratus, effect of the effect with adding sodium acid carbonate
Unanimously；One kind in propane diols or polyethylene glycol can also be used alone in anhydrous NMF, or uses glycerine, propane diols or poly-
The mixture of its any combination of ethylene glycol；Adhesive can use sodium hydroxyethyl cellulose, sodium carboxymethylcellulose, carragheen,
Xanthans or carbomer single component or compound；Sweetener can use saccharin sodium, the sweet tea that sharps teeth, stevioside, stevioside, wood
One or more mixing in sugar alcohol；Essence can use peppermint, spearmint essence, American mint, one kind in anethole or more
Kind mixing.Selected above is the conventional selection for making oral-cavity article, toothpaste or gel.
The preparation method of embodiment one is to be firstly added anhydrous NMF, adds the quick stirring homogeneous of adhesive, acid,
Then sweetener, emulsifying agent, binding agent, pH adjusting agent, alkali are sequentially added, then vacuumizes addition rubbing agent, stirs homogeneous, is taken off
Gas, prepare and complete.The preparation method of two~embodiment of embodiment ten is consistent with the preparation method of embodiment one.
Below by taking embodiment 11 as an example, the preparation method of oral cavity composition of the present invention is illustrated, operating procedure is as follows：
1) acid in sweetener, disintegrant is taken, the acid in sweetener, disintegrant is added into anhydrous moisturizing simultaneously by stirring
It is well mixed in agent；
2) rubbing agent, emulsifying agent, binding agent and pH adjusting agent are taken, and is well mixed；
3) after the material mixing obtained by step 1), 2), add in Manufacturing medicine extract machine after stirring 30min, add essence, collapse
The alkali in agent is solved, is continued after stirring 10min, is prepared and complete.
The preparation method of embodiment 11 to embodiment 15 is consistent.
When one~embodiment of embodiment 15, one~comparative example of comparative example four prepare completion, its stability and cream are observed
Body denseness.The judgement of stability is：If there is bubble to emerge, illustrate that disintegrant occurs disintegration and melted, stability is poor, if lotion
Any change does not occur, then illustrates that paste stability is good；The judgement of pasty consistence is：By lotion bar from first steel on denseness frame
Silk starts to cross to remaining steel wire successively, makes cream bar crossbearer on steel wire, and every lotion continuously squeezes 3, static 1min after having squeezed,
Observation lotion, which breaks, falls situation.There are 2 identicals across the cream bar ultimate range that falls of not breaking on steel wire for single branch measure knot in 3
Fruit.If it breaks, the ultimate range fallen is less than 9mm or is all considered as more than 33mm unqualified；If cream bar ultimate range 9mm-33mm it
Between, it is qualified to be determined as.One~embodiment of embodiment 15, the stability of one~comparative example of comparative example four and pasty consistence result are such as
Shown in table 2：
Table 2
| Stability | Denseness | |
| Embodiment one | Do not produce bubble | It is thicker, do not influence to use |
| Embodiment two | Do not produce bubble | It is diluter, do not influence to use |
| Embodiment three | Do not produce bubble | It is thicker, do not influence to use |
| Example IV | Do not produce bubble | Properly |
| Embodiment five | Do not produce bubble | Properly |
| Embodiment six | Do not produce bubble | Properly |
| Embodiment seven | Do not produce bubble | Properly |
| Embodiment eight | Do not produce bubble | It is thicker, do not influence to use |
| Embodiment nine | Do not produce bubble | It is diluter, do not influence to use |
| Embodiment ten | Do not produce bubble | It is thicker, do not influence to use |
| Comparative example one | Produce a small amount of bubble | It is diluter, do not influence to use |
| Comparative example two | Produce a small amount of bubble | It is diluter, do not influence to use |
| Comparative example three | Do not produce bubble | It is thick, can not use |
| Comparative example four | Do not produce bubble | It is dilute, can not use |
| Embodiment 11 | Do not produce bubble | Properly |
| Embodiment 12 | Do not produce bubble | Properly |
| Embodiment 13 | Do not produce bubble | Properly |
| Embodiment 14 | Do not produce bubble | Properly |
| Embodiment 15 | Do not produce bubble | Properly |
| Comparative example five | Do not produce bubble | It is thick, can not use |
| Comparative example six | Do not produce bubble | It is thick, can not use |
| Comparative example seven | Do not produce bubble | It is dilute, can not use |
| Comparative example eight | Do not produce bubble | It is dilute, can not use |
As shown in Table 2, the stability of one~embodiment of embodiment ten is preferable, although one~embodiment of embodiment three compared with
It is thick, do not influence to use, although eight~embodiment of embodiment ten is diluter, but do not influence to use, and example IV~implementation
Example seven is optimal number range；Comparative example one, comparative example two be the lotion with perfume ingredient and with commonly use preparation method
It is made, produces a small amount of bubble, but does not influence to use, it can be seen that, after adding water in the composition of lotion, then stability is slightly worse,
And 11~embodiment of embodiment 15, the lotion added with perfume ingredient is similarly, preparation method is using oral cavity of the invention
Preparation method of composition, then it can avoid producing bubble, solve the problems, such as stability；Three~comparative example of comparative example eight is NMF
Measure excessive or very few, outside scope, cause lotion either thicker or diluter, lead to not use.
2nd, oral cavity composition of the present invention, when being gelinite, the raw material composition of each embodiment is as shown in table 3, unit, g：
Table 3
16~embodiment of embodiment 30, the acid of disintegrant in nine~comparative example of comparative example 18, citric acid are replaced
It is consistent with the effect for adding citric acid for one or several kinds of mixtures in tartaric acid, fumaric acid, malic acid, effect；Alkali, carbon
Sour hydrogen sodium replaces with one or more of mixtures in sodium carbonate, potassium carbonate, saleratus, and effect is with adding sodium acid carbonate
Effect is consistent；One kind in propane diols or polyethylene glycol can also be used alone in anhydrous NMF, or uses glycerine, propane diols
Or polyethylene glycol its any combination mixture；Adhesive can use sodium hydroxyethyl cellulose, sodium carboxymethylcellulose, OK a karaoke club
Glue, xanthans or carbomer single component or compound；Sweetener can use saccharin sodium, the sweet tea that sharps teeth, stevioside, card to breathe out Job's tears
One or more mixing in glycosides, xylitol；Essence can use one kind in peppermint, spearmint essence, American mint, anethole
Or a variety of mixing.Selected above is the conventional selection for making gelinite toothpaste.
Embodiment 16~25, the preparation method of nine~comparative example of comparative example 13 and the preparation method one of embodiment one
Cause.
26~embodiment of embodiment 30, the preparation method of 14~comparative example of comparative example 16 and embodiment 11
Preparation method it is consistent；
The denseness of 16~embodiment of embodiment 30, the stability of nine~comparative example of comparative example 18 and gelinite is surveyed
Examination, the view mode of stability is consistent with the view mode of one~embodiment of embodiment 15, and denseness then uses the mode of range estimation, only
Otherwise use is influenceed, as a result as shown in table 4：
Table 4
| Stability | Denseness | |
| Embodiment 16 | Do not produce bubble | It is thicker, do not influence to use |
| Embodiment 17 | Do not produce bubble | It is diluter, do not influence to use |
| Embodiment 18 | Do not produce bubble | It is thicker, do not influence to use |
| Embodiment 19 | Do not produce bubble | Properly |
| Embodiment 20 | Do not produce bubble | Properly |
| Embodiment 21 | Do not produce bubble | Properly |
| Embodiment 22 | Do not produce bubble | Properly |
| Embodiment 23 | Do not produce bubble | It is thicker, do not influence to use |
| Embodiment 24 | Do not produce bubble | It is diluter, do not influence to use |
| Embodiment 25 | Do not produce bubble | It is thicker, do not influence to use |
| Comparative example nine | Produce a small amount of bubble | It is diluter, do not influence to use |
| Comparative example ten | Produce a small amount of bubble | It is diluter, do not influence to use |
| Comparative example 11 | Do not produce bubble | It is thick, can not use |
| Comparative example 12 | Do not produce bubble | It is dilute, can not use |
| Comparative example 13 | Do not produce bubble | Properly |
| Embodiment 26 | Do not produce bubble | Properly |
| Embodiment 27 | Do not produce bubble | Properly |
| Embodiment 28 | Do not produce bubble | Properly |
| Embodiment 29 | Do not produce bubble | Properly |
| Embodiment 30 | Do not produce bubble | It is thick, can not use |
| Comparative example 14 | Do not produce bubble | It is thick, can not use |
| Comparative example 15 | Do not produce bubble | It is dilute, can not use |
| Comparative example 16 | Do not produce bubble | It is dilute, can not use |
As shown in Table 3, the stability of 11~embodiment of embodiment 25 is preferable, 16~embodiment of embodiment ten
Although eight is thicker, do not influence to use, although 23~embodiment of embodiment 25 is diluter, do not influence to use,
And 19~embodiment of embodiment 22 is optimal number range；Comparative example nine, comparative example comparative example ten are with essence
The gelinite of composition is simultaneously made of conventional preparation method, produces a small amount of bubble, it can be seen that, add water in the composition of gelinite
Afterwards, then stability is slightly worse, and 26~embodiment of embodiment 29, is similarly the gelinite added with perfume ingredient, system
Preparation Method can then be avoided producing bubble, be solved the problems, such as stability using the oral cavity composition preparation method of the present invention；Comparative example
14~comparative example 16 is that moisturizing dosage is excessive or very few, outside scope, cause gelinite either thicker otherwise compared with
It is dilute, lead to not use.
One~embodiment of above-described embodiment five is loaded in capsule with equipment, and capsule is made；Six~embodiment of embodiment ten is pressed
Dried after piece, tablet is made；The method of spray drying of 11~embodiment of embodiment 15, is made particle, loaded in bag；It is real
Apply 16~embodiment of example 30 and capsule is made.Capsule, tablet, particle are being carried with, in use, being placed directly in mouth
In chamber, with being reacted after saliva, it is disintegrated and melts, cleans oral cavity；Or by capsule, tablet, particle is positioned in water makes it
After dissolving, mouthwash use is made, is also dissolvable in water in physiological saline.
For those skilled in the art, on the premise of technical solution of the present invention is not departed from, if can also make
Dry modification and improvement, these should also be considered as protection scope of the present invention, these all without influence effect that the present invention implemented and
Practical applicability.
Claims (9)
- A kind of 1. oral cavity composition, it is characterised in that：It is lotion or gelinite, and raw material includes disintegrant, anhydrous moisturizing Agent, rubbing agent, emulsifying agent, sweetener, binding agent and pH adjusting agent, and the mass fraction of each raw material is：Disintegrant 10-30 parts, Anhydrous NMF 10-70, rubbing agent 5-50 parts, emulsifying agent 0.1-10 parts, sweetener 0.01-3 parts, binding agent 0.1-10 parts, pH Conditioning agent 1-15 parts；Described disintegrant is made up of bronsted lowry acids and bases bronsted lowry, and each mass fraction is：Sour 4.34 ~ 20 parts, 5.66 ~ 22.73 parts of alkali；Acid is citric acid, one or more of mixtures in tartaric acid, fumaric acid, malic acid；Alkali be sodium carbonate, sodium acid carbonate, One or more of mixtures in potassium carbonate.
- 2. oral cavity composition as claimed in claim 1, it is characterised in that：The raw material also includes essence, when it is lotion, respectively The mass fraction of raw material is：5 ~ 15 parts of acid, 6 ~ 15 parts of alkali, anhydrous NMF 20-50 parts, rubbing agent 15-30 parts, emulsifying agent 0.1- 3 parts, sweetener 1.8-2.5 parts, binding agent 0.1-3 parts, pH adjusting agent 1-15 parts, essence 0.9-1.2 parts.
- 3. oral cavity composition as claimed in claim 2, it is characterised in that：The mass fraction of each raw material is：Sour 7.5 parts, alkali 10 parts, 45 parts of anhydrous NMF, 25 parts of rubbing agent, 1 part of emulsifying agent, 2.0 parts of sweetener, 0.5 part of binding agent, 8 parts of pH adjusting agent, 1 part of essence.
- 4. oral cavity composition as claimed in claim 1, it is characterised in that：The raw material also includes essence, when it is gelinite, The mass fraction of each raw material is：5 ~ 15 parts of acid, alkali 6-15 parts, anhydrous NMF 40-70, rubbing agent 10-15 parts, emulsifying agent 0.5- 3 parts, sweetener 1.8-2.5 parts, binding agent 0.1-3 parts, pH adjusting agent 1-15 parts, essence 0.9-1.2 parts.
- 5. oral cavity composition as claimed in claim 4, it is characterised in that：The mass fraction of described each raw material is：7.5 parts of acid, 7.5 parts of alkali, 60 parts of anhydrous NMF, 15 parts of rubbing agent, 1 part of emulsifying agent, 2.0 parts of sweetener, 0.5 part of binding agent, pH adjusting agent 5.5 parts, 1 part of essence.
- 6. the preparation method of oral cavity composition as described in any one in claim 2 ~ 5, it is characterised in that：Its operating procedure is such as Under：1）Acid, the sweetener in disintegrant are taken, the acid in disintegrant and sweetener are added into anhydrous NMF simultaneously by stirring In be well mixed；2）Rubbing agent, emulsifying agent, binding agent and pH adjusting agent are taken, and is well mixed；3）By step 1）、2）After obtained material mixing, add in Manufacturing medicine extract machine after stirring, add in essence and disintegrant Alkali, continue to stir, prepare and complete.
- 7. utilize oral preparation made of the oral cavity composition as described in Claims 2 or 3, it is characterised in that：Including capsule.
- 8. utilize oral preparation made of the oral cavity composition as described in claim 4 or 5, it is characterised in that：Including capsule.
- 9. the application of oral preparation as claimed in claim 7, it is characterised in that：Described capsule is dissolved in liquid and obtained Liquid dentifrice, Clearer or collutory.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1179972A (en) * | 1997-09-29 | 1998-04-29 | 杨成玉 | Multifunctional effervescent for cleaning mouth |
| CN1306814A (en) * | 2000-01-25 | 2001-08-08 | 刘双华 | Gargle tablet |
| CN1861039A (en) * | 2006-04-14 | 2006-11-15 | 张少辉 | Chewing bubble-producing type solid tooth-paste |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100294515B1 (en) * | 1998-12-05 | 2001-07-12 | 양주환 | Effervescent tablet for oral cleaning and preparation method thereof |
-
2015
- 2015-07-21 CN CN201510433887.8A patent/CN104997660B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1179972A (en) * | 1997-09-29 | 1998-04-29 | 杨成玉 | Multifunctional effervescent for cleaning mouth |
| CN1306814A (en) * | 2000-01-25 | 2001-08-08 | 刘双华 | Gargle tablet |
| CN1861039A (en) * | 2006-04-14 | 2006-11-15 | 张少辉 | Chewing bubble-producing type solid tooth-paste |
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| Publication number | Publication date |
|---|---|
| CN104997660A (en) | 2015-10-28 |
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