CN104997660A - Oral cavity composition, preparation method and oral cavity preparation and application thereof - Google Patents
Oral cavity composition, preparation method and oral cavity preparation and application thereof Download PDFInfo
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Abstract
The invention discloses an oral cavity composition which is paste or gel. The oral cavity composition comprises, by mass, the raw materials of 10-30 parts of disintegrating agents, 10-70 parts of non-water humectants, 5-50 parts of friction agents, 0.1-10 parts of emulsifying agents, 0.01-3 parts of sweetening agents, 0.1-10 parts of binding agents and 1-15 parts of pH regulators. According to the oral cavity composition, the disintegrating agents are used in paste or gel of tooth paste, and the stability is good.
Description
Technical field
The invention belongs to composition for oral cavity field, be specifically related to a kind ofly meet water fast reaction, the oral cavity composition producing a large amount of bubble, preparation method, oral preparation and application thereof.
Background technology
At present, oral care product cleaning oral cavity and the tooth such as the common employing toothpaste of people, collutory.But in daily use procedure, toothpaste there will be the shortcoming of bad dispersibility in use; such as, when toothpaste squeeze brush teeth at the enterprising entrance cavity of toothbrush time, enter oral cavity to Tooth paste brush go out bubble during this period of time in; usually have a small amount of toothpaste to drop, this phenomenon is the bad dispersibility of toothpaste.Therefore, someone expects the principle of such as effervescent tablet to be added in oral-cavity article, effervescent tablet is a kind of tablet containing gas-producing disintegrant, and so-called gas-producing disintegrant is organic acid and sodium carbonate, sodium bicarbonate (sodium bicarbonate), the i.e. mixture of bronsted lowry acids and bases bronsted lowry normally; The dry moisture-free of effervescent tablet itself, two kinds of materials in gas-producing disintegrant are unionized can not react; But after water put into by effervescent tablet, two kinds ionize, and metathesis reaction occur under the effect of water, produce great amount of carbon dioxide, make the rapid disintegrate of tablet and thawing, the bubble that disintegrate sometimes produces also can make tablet roll up and down in water, accelerates its disintegrate and thawing.As can be seen here, disintegrating agent is used in toothpaste, when toothpaste enters in oral cavity, bubble can be produced, rapid disintegrate and thawing, but usually contain wetting agent in the mastic of toothpaste or gelinite, essence, and usually all containing moisture in wetting agent, therefore, if simply disintegrating agent is added in existing lotion of toothpaste or in gelinite, then because there is the existence of moisture to occur the phenomenon of disintegrate and thawing in advance, less stable, as can be seen here, disintegrating agent is used in technological difficulties maximum in oral-cavity article to be to need anhydrous environment, if and anhydrous in the mastic of toothpaste after, mastic then can be caused feeding-up, cannot use.Therefore, existing have disintegrating agent is made cleaning tablet of oral cavity, such as, Chinese patent notification number is that the patent of invention of CN 103479525 A discloses a kind of cleaning tablet of oral cavity and preparation method thereof, this cleaning tablet of oral cavity contains three-decker, and cleaning agent is also sealed in microcapsule layer by microcapsule layer parcel cleaning agent; Disintegrate layer is positioned at the periphery of microcapsule layer.The range of application of this tablet is narrower, in the mastic that cannot be applied in toothpaste or gelinite.Therefore, the present inventor studies in the mastic or gelinite that disintegrating agent is added in toothpaste, find in research, part material in the mastic of toothpaste or gelinite is changed, and when the material composition in disintegrating agent and mastic or gelinite according to a certain percentage proportioning time, the problem of the poor stability of disintegrating agent in mastic or gelinite can be solved.
In addition, the packaging volume of toothpaste is large, is not easy to carry, and uses and comparatively bother, and needs first to open dentifrice tube lid, and then be extruded on toothbrush by toothpaste before using; Especially for the people travelled outdoors, for trip brings many inconvenience.Therefore, inventor, in the process of research, finds mastic, gelinite to can be made into other portable oral preparations, solves the problem of carrying inconvenience, troublesome poeration.
Summary of the invention
The technical problem to be solved in the present invention provide a kind of disintegrating agent is used in toothpaste mastic or gelinite in and the oral cavity composition of good stability.
In order to solve the problems of the technologies described above, the invention provides following technical scheme: a kind of oral cavity composition, its raw material comprises disintegrating agent, anhydrous wetting agent, abrasivus, emulsifying agent, sweeting agent, binding agent and pH adjusting agent, and the mass fraction of each raw material is: disintegrating agent 10-30 part, anhydrous wetting agent 10-70, abrasivus 5-50 part, emulsifying agent 0.1-10 part, sweeting agent 0.01-3 part, binding agent 0.1-10 part, pH adjusting agent 1-15 part.
Adopt the oral cavity composition of technical solution of the present invention, the wetting agent of anhydrous wetting agent namely not containing moisture, generally include glycerol, Polyethylene Glycol, owing to not comprising water in raw material, therefore, avoid disintegrating agent to shift to an earlier date disintegrate and thawing, and after utilizing said ratio between each raw material, find obtained mastic or gelinite good stability and denseness is easy to use.
Preferably, described disintegrating agent is made up of bronsted lowry acids and bases bronsted lowry, and each mass fraction is: acid 4.34 ~ 27.27 parts, 5.66 ~ 22.73 parts, alkali.Acid is selected from one or more mixture in citric acid, tartaric acid, fumaric acid, malic acid; Alkali is selected from one or more mixture in sodium carbonate, sodium bicarbonate, potassium carbonate.
Preferably, raw material also includes essence, when it is mastic, the mass fraction of each raw material is: acid 5 ~ 15 parts, 6 ~ 15 parts, alkali, anhydrous wetting agent 20-50 part, abrasivus 15-30 part, emulsifying agent 0.1-3 part, sweeting agent 1.8-2.5 part, binding agent 0.1-3 part, pH adjusting agent 1-15 part, essence 0.9-1.2 part.When for above proportioning, the paste stability made is good, and denseness is closest to existing toothpaste denseness, easy to use.
Preferably, the mass fraction of described each raw material is: acid 7.5 parts, 10 parts, alkali, anhydrous wetting agent 45 parts, abrasivus 25 parts, emulsifying agent 1 part, sweeting agent 2.0 parts, binding agent 0.5 part, pH adjusting agent 8 parts, 1 part, essence.
Preferably, raw material also includes essence, when it is gelinite, the mass fraction of each raw material is: acid 5 ~ 15 parts, alkali 6-15 part, anhydrous wetting agent 40-70, abrasivus 10-15 part, emulsifying agent 0.5-3 part, sweeting agent 1.8-2.5 part, binding agent 0.1-3 part, pH adjusting agent 1-15 part, essence 0.9-1.2 part.
Preferably, the mass fraction of described each raw material is: acid 7.5 parts, 7.5 parts, alkali, anhydrous wetting agent 60 parts, abrasivus 15 parts, emulsifying agent 1 part, sweeting agent 2.0 parts, binding agent 0.5 part, pH adjusting agent 5.5 parts, 1 part, essence.
Another object of the present invention is to provide a kind of preparation method of above-mentioned oral cavity composition, better to solve the problem of stability.
Usually also can containing essence or the composition with certain effect in the mastic of existing toothpaste or gelinite, such as, the antiallergic factor, the whitening factor etc.; And essence normally utilizes the quintessence oil of extracted form natural plant or the essence of synthetic, it is normally liquid, therefore, when in toothpaste containing essence time, then inevasiblely there will be water, research finds, disintegrating agent can react with water, and a small amount of bubble appears in disintegrate in advance and thawing, but does not affect use, therefore, in order to head it off, inventor finds, by the preparation method of each raw material according to oral cavity composition of the present invention, can head it off, stability is still good.
For solving the preparation method problem of the oral cavity composition that the present invention proposes, the invention provides following technical scheme, its operating procedure is as follows:
1) getting the acid in disintegrating agent, sweeting agent, by stirring, the acid in disintegrating agent and sweeting agent being added mix homogeneously in anhydrous wetting agent simultaneously;
2) abrasivus, emulsifying agent, binding agent and pH adjusting agent is got, and mix homogeneously;
3) by step 1), 2) after the mixing of materials that obtains, add after stirring in Manufacturing medicine extract machine, then add the alkali in essence and disintegrating agent, continue to stir, preparation completes.
Above-mentioned steps, because bronsted lowry acids and bases bronsted lowry in disintegrating agent successively adds, and when finally adding essence and alkali, the water in essence can be absorbed rapidly by the abrasivus added in advance, thus avoids bronsted lowry acids and bases bronsted lowry to meet water disintegrate and thawing, good stability simultaneously.
Another object of the present invention be to provide a kind ofly to be easy to carry, easy to operate oral preparation.
In order to solve portable problem, the invention provides following technical scheme: utilize the oral preparation that oral cavity composition is made, comprising capsule, tablet, granule.Mastic is loaded in capsule, makes capsule; Drying after mastic tabletting is then made tablet; Then granule is made after being granulated by mastic; And gel can be loaded in capsule and makes capsule.Capsule, tablet, granule, then when going out, can directly carry, and during use, only need to be positioned in oral cavity, react with the saliva in oral cavity, disintegrate and thawing, then for cleaning teeth, easy to operate, be easy to carry.
Another object of the present invention is to provide a kind of application of above-mentioned oral preparation, makes applied range.
The invention provides following technical scheme: described capsule, tablet, granule are dissolved in liquid and obtain aqueous dentifrice, Clearer or collutory.In daily life, cleaning teeth is not limited to tooth gel, toothpaste etc., also available collutory, Clearer or other aqueous dentifrices, therefore, the above-mentioned capsule for cleaning teeth, tablet, granule are dissolved in liquid, make aqueous dentifrice, Clearer or collutory, on easy to carry, easy to operate basis, the range of application of above-mentioned oral preparation can be made again wider.
Detailed description of the invention
One, oral cavity composition of the present invention, during for mastic, the raw material composition of each embodiment is as shown in table 1, unit g:
Table 1
The acid of the disintegrating agent in embodiment one ~ embodiment 15, comparative example one ~ comparative example eight, citric acid replace with one or several mixture in tartaric acid, fumaric acid, malic acid, and effect is consistent with the effect of adding citric acid; Alkali, sodium bicarbonate replace with one or more mixture in sodium carbonate, potassium carbonate, potassium bicarbonate, and effect is all consistent with the effect of adding sodium bicarbonate; Anhydrous wetting agent can also be used alone the one in propylene glycol or Polyethylene Glycol, or uses the mixture of glycerol, propylene glycol or its combination in any of Polyethylene Glycol; Binding agent can use sodium hydroxyethyl cellulose, sodium carboxymethyl cellulose, carrageenan, xanthan gum or carbomer single component or compound; Sweeting agent can use saccharin sodium, it is sweet to sharp teeth, one or more mixing in stevioside, stevioside, xylitol; Essence can use one or more mixing in Herba Menthae, Herba Menthae Rotundifoliae essence, Mentha piperita, anethole.More than select to be the routine making oral-cavity article, toothpaste or gel to select.
The preparation method of embodiment one is first add anhydrous wetting agent, then adds binding agent, sour rapid stirring homogenizing, then add sweeting agent, emulsifying agent, binding agent, pH adjusting agent, alkali successively, then evacuation adds abrasivus, stirs homogenizing, degassed, preparation completes.The preparation method of embodiment two ~ embodiment ten is consistent with embodiment one preparation method.
Below for embodiment 11, illustrate the preparation method of oral cavity composition of the present invention, operating procedure is as follows:
1) getting the acid in sweeting agent, disintegrating agent, by stirring, the acid in sweeting agent, disintegrating agent being added mix homogeneously in anhydrous wetting agent simultaneously;
2) abrasivus, emulsifying agent, binding agent and pH adjusting agent is got, and mix homogeneously;
3) by step 1), 2) after the mixing of materials that obtains, add after stirring 30min in Manufacturing medicine extract machine, then add the alkali in essence, disintegrating agent, after continuing to stir 10min, preparation completes.
The preparation method of embodiment 10 one to embodiment 15 is consistent.
When prepared by embodiment one ~ embodiment 15, comparative example one ~ comparative example four, its stability and pasty consistence are observed.The judgement of stability is: if there is bubble to emerge, then disintegrating agent generation disintegrate and thawing are described, poor stability, if any change does not occur mastic, then illustrates that paste stability is good; The judgement of pasty consistence is: crossed to all the other steel wires successively first steel wire from denseness frame by mastic bar, makes cream bar crossbearer on steel wire, often props up mastic and squeezes 3 continuously, squeezed rear static 1min, and observation mastic breaks the situation that falls.Article 3, in, there are 2 identical cream bar ultimate ranges fallen across not breaking on steel wire to be single measurement result.If it breaks, the ultimate range that falls is less than 9mm or is greater than 33mm and is all considered as defective; If cream bar ultimate range is between 9mm-33mm, it is qualified to be judged to be.Stability and the pasty consistence result of embodiment one ~ embodiment 15, comparative example one ~ comparative example four are as shown in table 2:
Table 2
| Stability | Denseness | |
| Embodiment one | Do not produce bubble | Thicker, do not affect use |
| Embodiment two | Do not produce bubble | Rarer, do not affect use |
| Embodiment three | Do not produce bubble | Thicker, do not affect use |
| Embodiment four | Do not produce bubble | Suitable |
| Embodiment five | Do not produce bubble | Suitable |
| Embodiment six | Do not produce bubble | Suitable |
| Embodiment seven | Do not produce bubble | Suitable |
| Embodiment eight | Do not produce bubble | Thicker, do not affect use |
| Embodiment nine | Do not produce bubble | Rarer, do not affect use |
| Embodiment ten | Do not produce bubble | Thicker, do not affect use |
| Comparative example one | Produce a small amount of bubble | Rarer, do not affect use |
| Comparative example two | Produce a small amount of bubble | Rarer, do not affect use |
| Comparative example three | Do not produce bubble | Thick, cannot use |
| Comparative example four | Do not produce bubble | Rare, cannot use |
| Embodiment 11 | Do not produce bubble | Suitable |
| Embodiment 12 | Do not produce bubble | Suitable |
| Embodiment 13 | Do not produce bubble | Suitable |
| Embodiment 14 | Do not produce bubble | Suitable |
| Embodiment 15 | Do not produce bubble | Suitable |
| Comparative example five | Do not produce bubble | Thick, cannot use |
| Comparative example six | Do not produce bubble | Thick, cannot use |
| Comparative example seven | Do not produce bubble | Rare, cannot use |
| Comparative example eight | Do not produce bubble | Rare, cannot use |
As shown in Table 2, the stability of embodiment one ~ embodiment ten is all better, although embodiment one ~ embodiment three is thicker, but do not affect use, although embodiment eight ~ embodiment ten is rarer, do not affect use, and embodiment four ~ embodiment seven is best numerical range; Comparative example one, comparative example two are for having the mastic of perfume ingredient and making by conventional preparation method, produce a small amount of bubble, but do not affect use, as can be seen here, after adding water in the composition of mastic, then stability is slightly poor, and embodiment 11 ~ embodiment 15, be similarly the mastic being added with perfume ingredient, preparation method adopts oral cavity composition preparation method of the present invention, then can avoid producing bubble, solve the problem of stability; It is too much or very few that comparative example three ~ comparative example eight is moisturizing dosage, outside scope, causes mastic thicker or rarer, cause using.
Two, oral cavity composition of the present invention, during for gelinite, the raw material composition of each embodiment is as shown in table 3, unit, g:
Table 3
The acid of the disintegrating agent in embodiment 16 ~ embodiment 30, comparative example nine ~ comparative example 18, citric acid replace with one or several mixture in tartaric acid, fumaric acid, malic acid, and effect is consistent with the effect of adding citric acid; Alkali, sodium bicarbonate replace with one or more mixture in sodium carbonate, potassium carbonate, potassium bicarbonate, and effect is all consistent with the effect of adding sodium bicarbonate; Anhydrous wetting agent can also be used alone the one in propylene glycol or Polyethylene Glycol, or uses the mixture of glycerol, propylene glycol or its combination in any of Polyethylene Glycol; Binding agent can use sodium hydroxyethyl cellulose, sodium carboxymethyl cellulose, carrageenan, xanthan gum or carbomer single component or compound; Sweeting agent can use saccharin sodium, it is sweet to sharp teeth, one or more mixing in stevioside, stevioside, xylitol; Essence can use one or more mixing in Herba Menthae, Herba Menthae Rotundifoliae essence, Mentha piperita, anethole.More than select to be the routine making gelinite toothpaste to select.
The preparation method of embodiment 16 ~ 25, comparative example nine ~ comparative example 13 is consistent with embodiment one preparation method.
The preparation method of embodiment 26 ~ embodiment 30, comparative example 14 ~ comparative example 16 is consistent with the preparation method of embodiment 11;
Embodiment 16 ~ embodiment 30, the stability of comparative example nine ~ comparative example 18 and the consistency testing of gelinite, the view mode of stability is consistent with the view mode of embodiment one ~ embodiment 15, denseness is then by the mode of range estimation, and only otherwise impact uses, result is as shown in table 4:
Table 4
| Stability | Denseness | |
| Embodiment 16 | Do not produce bubble | Thicker, do not affect use |
| Embodiment 17 | Do not produce bubble | Rarer, do not affect use |
| Embodiment 18 | Do not produce bubble | Thicker, do not affect use |
| Embodiment 19 | Do not produce bubble | Suitable |
| Embodiment 20 | Do not produce bubble | Suitable |
| Embodiment 21 | Do not produce bubble | Suitable |
| Embodiment 22 | Do not produce bubble | Suitable |
| Embodiment 23 | Do not produce bubble | Thicker, do not affect use |
| Embodiment 24 | Do not produce bubble | Rarer, do not affect use |
| Embodiment 25 | Do not produce bubble | Thicker, do not affect use |
| Comparative example nine | Produce a small amount of bubble | Rarer, do not affect use |
| Comparative example ten | Produce a small amount of bubble | Rarer, do not affect use |
| Comparative example 11 | Do not produce bubble | Thick, cannot use |
| Comparative example 12 | Do not produce bubble | Rare, cannot use |
| Comparative example 13 | Do not produce bubble | Suitable |
| Embodiment 26 | Do not produce bubble | Suitable |
| Embodiment 27 | Do not produce bubble | Suitable |
| Embodiment 28 | Do not produce bubble | Suitable |
| Embodiment 29 | Do not produce bubble | Suitable |
| Embodiment 30 | Do not produce bubble | Thick, cannot use |
| Comparative example 14 | Do not produce bubble | Thick, cannot use |
| Comparative example 15 | Do not produce bubble | Rare, cannot use |
| Comparative example 16 | Do not produce bubble | Rare, cannot use |
As shown in Table 3, the stability of embodiment 11 ~ embodiment 25 is all better, although embodiment 16 ~ embodiment 18 is thicker, but do not affect use, although embodiment 23 ~ embodiment 25 is rarer, but do not affect use, and embodiment 19 ~ embodiment 22 is best numerical range; Comparative example nine, comparative example comparative example ten are for having the gelinite of perfume ingredient and making by conventional preparation method, produce a small amount of bubble, as can be seen here, after adding water in the composition of gelinite, then stability is slightly poor, and embodiment 26 ~ embodiment 29, be similarly the gelinite being added with perfume ingredient, preparation method adopts oral cavity composition preparation method of the present invention, then can avoid producing bubble, solves the problem of stability; It is too much or very few that comparative example 14 ~ comparative example 16 is moisturizing dosage, outside scope, causes gelinite thicker or rarer, cause using.
Above-described embodiment one ~ embodiment five equipment is loaded in capsule, makes capsule; Dry after embodiment six ~ embodiment ten tabletting, make tablet; The spray-dired method of embodiment 11 ~ embodiment 15, makes granule, is loaded in bag; Embodiment 16 ~ embodiment 30 all makes capsule.Capsule, tablet, granule are all being carried with, and during use, are directly positioned in oral cavity, react with after saliva, disintegrate and thawing, cleaning oral cavity; Or after capsule, tablet, granule are positioned in water and make it dissolve, make collutory and use, be also dissolvable in water in normal saline.
For a person skilled in the art, under the prerequisite not departing from technical solution of the present invention, can also make some distortion and improvement, these also should be considered as protection scope of the present invention, and these all can not affect effect of the invention process and practical applicability.
Claims (10)
1. an oral cavity composition, it is characterized in that: it is mastic or gelinite, raw material includes disintegrating agent, anhydrous wetting agent, abrasivus, emulsifying agent, sweeting agent, binding agent and pH adjusting agent, and the mass fraction of each raw material is: disintegrating agent 10-30 part, anhydrous wetting agent 10-70, abrasivus 5-50 part, emulsifying agent 0.1-10 part, sweeting agent 0.01-3 part, binding agent 0.1-10 part, pH adjusting agent 1-15 part.
2. oral cavity composition as claimed in claim 1, it is characterized in that: described disintegrating agent is made up of bronsted lowry acids and bases bronsted lowry, and each mass fraction is: acid 4.34 ~ 27.27 parts, 5.66 ~ 22.73 parts, alkali.
3. oral cavity composition as claimed in claim 2, it is characterized in that: described raw material also includes essence, when it is mastic, the mass fraction of each raw material is: acid 5 ~ 15 parts, 6 ~ 15 parts, alkali, anhydrous wetting agent 20-50 part, abrasivus 15-30 part, emulsifying agent 0.1-3 part, sweeting agent 1.8-2.5 part, binding agent 0.1-3 part, pH adjusting agent 1-15 part, essence 0.9-1.2 part.
4. oral cavity composition as claimed in claim 3, is characterized in that: the mass fraction of described each raw material is: acid 7.5 parts, 10 parts, alkali, anhydrous wetting agent 45 parts, abrasivus 25 parts, emulsifying agent 1 part, sweeting agent 2.0 parts, binding agent 0.5 part, pH adjusting agent 8 parts, 1 part, essence.
5. oral cavity composition as claimed in claim 2, it is characterized in that: described raw material also includes essence, when it is gelinite, the mass fraction of each raw material is: acid 5 ~ 15 parts, alkali 6-15 part, anhydrous wetting agent 40-70, abrasivus 10-15 part, emulsifying agent 0.5-3 part, sweeting agent 1.8-2.5 part, binding agent 0.1-3 part, pH adjusting agent 1-15 part, essence 0.9-1.2 part.
6. oral cavity composition as claimed in claim 5, is characterized in that: the mass fraction of described each raw material is: acid 7.5 parts, 7.5 parts, alkali, anhydrous wetting agent 60 parts, abrasivus 15 parts, emulsifying agent 1 part, sweeting agent 2.0 parts, binding agent 0.5 part, pH adjusting agent 5.5 parts, 1 part, essence.
7. as the preparation method of oral cavity composition as described in any one in claim 3 ~ 6, it is characterized in that: its operating procedure is as follows:
1) getting the acid in disintegrating agent, sweeting agent, by stirring, the acid in disintegrating agent and sweeting agent being added mix homogeneously in anhydrous wetting agent simultaneously;
2) abrasivus, emulsifying agent, binding agent and pH adjusting agent is got, and mix homogeneously;
3) by step 1), 2) after the mixing of materials that obtains, add after stirring in Manufacturing medicine extract machine, then add the alkali in essence and disintegrating agent, continue to stir, preparation completes.
8. the oral preparation utilizing oral cavity composition to make as described in claim 3 or 4, is characterized in that: comprise capsule, tablet, granule.
9. the oral preparation utilizing oral cavity composition to make as described in claim 5 or 6, is characterized in that: comprise capsule.
10. the application of oral preparation as claimed in claim 8, is characterized in that: described capsule, tablet, granule are dissolved in liquid and obtain aqueous dentifrice, Clearer or collutory.
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| CN1179972A (en) * | 1997-09-29 | 1998-04-29 | 杨成玉 | Multifunctional effervescent for cleaning mouth |
| WO2000033800A1 (en) * | 1998-12-05 | 2000-06-15 | Suheung Capsule Co., Ltd. | A foaming tablet for cleaning the oral cavity and preparation method thereof |
| CN1306814A (en) * | 2000-01-25 | 2001-08-08 | 刘双华 | Gargle tablet |
| CN1861039A (en) * | 2006-04-14 | 2006-11-15 | 张少辉 | Chewing bubble-producing type solid tooth-paste |
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2015
- 2015-07-21 CN CN201510433887.8A patent/CN104997660B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1179972A (en) * | 1997-09-29 | 1998-04-29 | 杨成玉 | Multifunctional effervescent for cleaning mouth |
| WO2000033800A1 (en) * | 1998-12-05 | 2000-06-15 | Suheung Capsule Co., Ltd. | A foaming tablet for cleaning the oral cavity and preparation method thereof |
| CN1306814A (en) * | 2000-01-25 | 2001-08-08 | 刘双华 | Gargle tablet |
| CN1861039A (en) * | 2006-04-14 | 2006-11-15 | 张少辉 | Chewing bubble-producing type solid tooth-paste |
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| Title |
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| 叶勇: "《制药工艺学》", 28 February 2014 * |
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