CN106265833A - A kind of Flos Lonicerae effervescent tablet and preparation method thereof - Google Patents
A kind of Flos Lonicerae effervescent tablet and preparation method thereof Download PDFInfo
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- CN106265833A CN106265833A CN201610633779.XA CN201610633779A CN106265833A CN 106265833 A CN106265833 A CN 106265833A CN 201610633779 A CN201610633779 A CN 201610633779A CN 106265833 A CN106265833 A CN 106265833A
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- flos lonicerae
- effervescent tablet
- dry powder
- gained
- extract dry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
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- Alternative & Traditional Medicine (AREA)
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- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of Flos Lonicerae effervescent tablet and preparation method thereof, this effervescent tablet is prepared from by the raw material of following mass percent: Lonicera confusa extract dry powder 4.3%；Gas-producing disintegrant, its quality accounts for the 40% of tablet weight；Adhesive polyvinylpyrrolidone K 30 10%；Lubricant polyethylene glycol 6000 5%；Sweeting agent aspartame is 1.5%；Remaining is lactose.The present invention not only maintains Flos Lonicerae effective efficiency composition, and retain Flos Lonicerae major part nutritional labeling largely, including trace element, vitamin, polysaccharide etc., define healthy nutritive value and the flavor characteristics of uniqueness, lipopolysaccharide-induced rat fever model there is is obvious refrigeration function, staphylococcus aureus, streptococcus pneumoniae and beta hemolysis streptococcus are had stronger inhibitory action；The Flos Lonicerae effervescent beverage(s) sheet of gained, it is easy to preserve, it is simple to carry, taking convenience, dissolves gained solution clarity good, has a Flos Lonicerae fragrance taste, and micro-acid is in good taste.
Description
Technical field
The present invention relates to field of traditional Chinese, be specifically related to a kind of Flos Lonicerae effervescent tablet and preparation method thereof.
Background technology
Flos Lonicerae is the dry flower of caprifoliaceae plant largeflower-like honeysuckle flower, Flos Lonicerae, Lonicera confusa or Lonicera fulvotnetosa Hsu et S. C. Cheng. Ms
Or the flower that band is just opened.It is born under small stream limit, wilderness sparse woods or in bushes.There is heat-clearing and toxic substances removing, effect of dispelling wind and heat pathogens, can be used for
Carbuncle treats skin ulcer, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease；Its Main Ingredients and Appearance is chlorogenic acid, luteoloside etc..
Effervescent tablet is a kind of tablet made for disintegrating agent with suitable organic acid and bicarbonate or carbonate, and meeting water can
Release great amount of carbon dioxide and in effervescent shape, oral effervescent tablet in cold water can rapid disintegrate, be beneficial to absorb, relatively its alloytype is taken
Band, taking convenience, it is adaptable to child, old people and the patient of solid preparation can not be swallowed.The formula of effervescent tablet and processing technique
Being the key factor affecting effervescent tablet quality, the concern of the most numerous scholars, such as vitamin C, instant tea, summer Sang Ju Yin effervescent tablet
Preparation.The beverage of one glass of sweet and sour taste it is, such as Fructus Momordicae charantiae, pumpkin corn powder bubble after quality preferable oral effervescent tablet effervescent
Rise sheet solid beverage.If Flos Lonicerae can be developed into effervescent tablet, it is convenient for carrying, adds water and just become lonicerae flos beverage, nozzle can be worked as again
Chew sheet, it is possible to the exploitation for the effervescent beverage(s) sheet of other plant liquid beverage provides thinking.Therefore, a kind of Flos Lonicerae effervescent of exploitation
The formula composition of sheet and processing technique are significant.
Summary of the invention
For solving the problems referred to above, the invention provides a kind of Flos Lonicerae effervescent tablet and preparation method thereof.
For achieving the above object, the technical scheme that the present invention takes is:
A kind of Flos Lonicerae effervescent tablet, is prepared from by the raw material of following mass percent:
Lonicera confusa extract dry powder 4.3%；Gas-producing disintegrant, its quality accounts for the 40% of tablet weight；Polyvinylpyrrolidone K-
30 10%；Polyethylene glycol 6000 5%；Aspartame is 1.5%；Remaining is lactose.
Wherein, described gas-producing disintegrant is mixed gained by sodium bicarbonate with tartaric acid mass ratio 0.6: 1.
Wherein, described Lonicera confusa extract dry powder prepares gained by following steps:
S1, Flos Lonicerae, Flos Chrysanthemi are mixed with Radix Glycyrrhizae in mass ratio 2: 1: 1 after, add mixture 7 times amount 50% ethanol
Solution, after being heated to reflux 2h, filters；Residue adds the ethanol solution of the 50% of 3 times amount and is heated to reflux 1h, merges secondary filter
Liquid, and concentrating under reduced pressure, obtain concentrated solution；
S2, after spray-dried for the concentrated solution of gained, obtain Lonicera confusa extract dry powder.
Present invention also offers the preparation method of a kind of Flos Lonicerae effervescent tablet, comprise the steps:
Step one, formula as described in claim 1 weigh each component；
After step 2, Lonicera confusa extract dry powder by being weighed, aspartame, lactose mixing and stirring, cross 80 mesh
Sieve, sprays into the ethanol solution soft material of PVP K-30.
Step 3, obtained soft material is crossed 18 mesh sieves pelletize, and dried the most respectively by 18 in 45 DEG C of baking ovens
Mesh and 80 mesh sieves carry out granulate；Add polyethylene glycol 6000, after mix homogeneously, tabletting, obtain Flos Lonicerae effervescent tablet.
The method have the advantages that
The most effectively maintain Flos Lonicerae effective efficiency composition, and retain Flos Lonicerae major part nutrition largely and become
Point, including trace element, vitamin, polysaccharide etc., define healthy nutritive value and the flavor characteristics of uniqueness, to lipopolysaccharide-induced
Rat fever model have obvious refrigeration function, staphylococcus aureus, streptococcus pneumoniae and beta hemolysis streptococcus are had
Stronger inhibitory action；The Flos Lonicerae effervescent beverage(s) sheet of gained, it is easy to preserve, it is simple to carry, taking convenience, dissolves gained solution
Clarity is good, has a Flos Lonicerae fragrance taste, and micro-acid is in good taste.
Accompanying drawing explanation
Fig. 1 is the flow chart of embodiment a kind of Flos Lonicerae effervescent tablet preparation method.
Detailed description of the invention
In order to make objects and advantages of the present invention clearer, below in conjunction with embodiment, the present invention is carried out further
Describe in detail.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not used to limit this
Bright.
Embodiments provide a kind of Flos Lonicerae effervescent tablet, the raw material of following mass percent be prepared from:
Lonicera confusa extract dry powder 4.3%；Gas-producing disintegrant, its quality accounts for the 40% of tablet weight；Polyvinylpyrrolidone K-
30 10%；Polyethylene glycol 6000 5%；Aspartame is 1.5%；Remaining is lactose.
Described gas-producing disintegrant is mixed gained by sodium bicarbonate with tartaric acid mass ratio 0.6: 1.
Described Lonicera confusa extract dry powder prepares gained by following steps:
S1, Flos Lonicerae, Flos Chrysanthemi are mixed with Radix Glycyrrhizae in mass ratio 2: 1: 1 after, add mixture 7 times amount 50% ethanol
Solution, after being heated to reflux 2h, filters；Residue adds the ethanol solution of the 50% of 3 times amount and is heated to reflux 1h, merges secondary filter
Liquid, and concentrating under reduced pressure, obtain concentrated solution；
S2, after spray-dried for the concentrated solution of gained, obtain Lonicera confusa extract dry powder.
As it is shown in figure 1, the embodiment of the present invention additionally provides the preparation method of a kind of Flos Lonicerae effervescent tablet, including walking as follows
Rapid:
Step one, formula as described in claim 1 weigh each component；
Step 2, by the Lonicera confusa extract dry powder weighed, aspartame it is, after lactose mixing and stirring, crosses 80
Mesh sieve, sprays into the ethanol solution soft material of PVP K-30.
Step 3, obtained soft material is crossed 18 mesh sieves pelletize, and dried the most respectively by 18 in 45 DEG C of baking ovens
Mesh and 80 mesh sieves carry out granulate；Add polyethylene glycol 6000, after mix homogeneously, tabletting, obtain Flos Lonicerae effervescent tablet.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For Yuan, under the premise without departing from the principles of the invention, it is also possible to make some improvements and modifications, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (4)
1. a Flos Lonicerae effervescent tablet, it is characterised in that be prepared from by the raw material of following mass percent:
Lonicera confusa extract dry powder 4.3%；Gas-producing disintegrant, its quality accounts for the 40% of tablet weight；PVP K-30
10%；Polyethylene glycol 6000 5%；Aspartame is 1.5%；Remaining is lactose.
A kind of Flos Lonicerae effervescent tablet the most according to claim 1, it is characterised in that described gas-producing disintegrant is by sodium bicarbonate
Gained is mixed with tartaric acid mass ratio 0.6: 1.
A kind of Flos Lonicerae effervescent tablet the most according to claim 1, it is characterised in that described Lonicera confusa extract dry powder passes through
Following steps prepare gained:
S1, Flos Lonicerae, Flos Chrysanthemi Indici are mixed with Radix Glycyrrhizae in mass ratio 2: 1: 1 after, add mixture 7 times amount 50% ethanol molten
Liquid, after being heated to reflux 2h, filters；Residue adds the ethanol solution of the 50% of 3 times amount and is heated to reflux 1h, merges secondary filtrate,
And concentrating under reduced pressure, obtain concentrated solution；
S2, after spray-dried for the concentrated solution of gained, obtain Lonicera confusa extract dry powder.
4. the preparation method of a Flos Lonicerae effervescent tablet, it is characterised in that comprise the steps:
Step one, formula as described in claim 1 weigh each component；
After step 2, Lonicera confusa extract dry powder by being weighed, aspartame, lactose mixing and stirring, cross 80 mesh sieves, spray
Enter the ethanol solution soft material of PVP K-30；
Step 3, obtained soft material crossed 18 mesh sieves pelletize, and in 45 DEG C of baking ovens dried the most respectively by 18 mesh and
80 mesh sieves carry out granulate, add polyethylene glycol 6000, after mix homogeneously, and tabletting, obtain Flos Lonicerae effervescent tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610633779.XA CN106265833A (en) | 2016-08-01 | 2016-08-01 | A kind of Flos Lonicerae effervescent tablet and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610633779.XA CN106265833A (en) | 2016-08-01 | 2016-08-01 | A kind of Flos Lonicerae effervescent tablet and preparation method thereof |
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| CN106265833A true CN106265833A (en) | 2017-01-04 |
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| CN201610633779.XA Pending CN106265833A (en) | 2016-08-01 | 2016-08-01 | A kind of Flos Lonicerae effervescent tablet and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110404046A (en) * | 2019-07-05 | 2019-11-05 | 吉林省桦树茸药业生物科技有限公司 | A method of preparing antigout plant sunflower disk extract active peptide effervescent tablet |
| CN112715711A (en) * | 2020-12-31 | 2021-04-30 | 上海大学 | Health-care type toona sinensis effervescent tablets and preparation method thereof |
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2016
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| CN101125130A (en) * | 2006-08-14 | 2008-02-20 | 北京四环科宝制药有限公司 | Indian chrysanthemum effervescent preparation and preparation method thereof |
| CN101138554A (en) * | 2006-09-05 | 2008-03-12 | 云南白药集团股份有限公司 | Effervescence dispersible tablet |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110404046A (en) * | 2019-07-05 | 2019-11-05 | 吉林省桦树茸药业生物科技有限公司 | A method of preparing antigout plant sunflower disk extract active peptide effervescent tablet |
| CN112715711A (en) * | 2020-12-31 | 2021-04-30 | 上海大学 | Health-care type toona sinensis effervescent tablets and preparation method thereof |
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Application publication date: 20170104 |
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