CN110404046A - A method of preparing antigout plant sunflower disk extract active peptide effervescent tablet - Google Patents
A method of preparing antigout plant sunflower disk extract active peptide effervescent tablet Download PDFInfo
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
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Abstract
The invention discloses a kind of methods for preparing antigout plant sunflower disk extract active peptide effervescent tablet, include the following steps: for each deal raw material to be sieved respectively with 30~45 meshes, collect sieving raw material；Active peptide, gas-producing disintegrant, starch, magnesium stearate and polyvinylpyrrolidone are mixed, the water for converting half deal stirs evenly, and stands 10~15min；Surplus stock is mixed into the raw material after standing, the water of remaining deal is added, is thoroughly mixed, obtains wet feed；Wet feed is granulated using pelletizer, passes through preliminarily dried after the completion of being granulated, it is dry to be dried to obtain half tide material using drier, 80~100 DEG C of drying temperature, 5~8min of drying time；The half tide material after preliminarily dried is subjected to tabletting using tablet press machine and obtains semifinished product.In the present invention, by the way that flavouring agent is added, flavouring agent taste can be according to actual selection, so that mouthfeel of the effervescent tablet when effervesce is taken is more preferable, user is easier to receive, and the product strength of enterprise gets a promotion.
Description
Technical field
The invention belongs to field of medicine preparing technology, specially a kind of to prepare antigout plant sunflower disk extract active peptide
The method of effervescent tablet.
Background technique
Gout is a kind of metabolic disease caused by purine metabolic disturbance, and serum Uric Acid Concentration increases, sodium urate crystals deposition with
Lower limb Bones and joints, artery, vertebrae gap tissue and cause, show as joint it is red, it is swollen, hot, pain, joint motion is unfavorable, seriously
Person is in joint deformity and dysfunction, and has the characteristics that recurrent exerbation.The presence of gout can also result in coronary heart disease, diabetes,
The deterioration of the diseases such as hypertension.In terms for the treatment of, western modern medicine treats gout, the method that there is no radical cure, colchicin, nonsteroidal
Though the drugs such as anti-inflammatory agent, allopurinol can reduce symptom, blood uric acid is reduced, its effect is more single, is difficult fundamentally to treat
Gout, and take for a long time such Western medicine injured caused by body it is more more than therapeutic effect.
Floral disc of sunflower is the floral disc of compositae plant sunflower, also known as sunflower receptacle, sunflower disc and certain herbaceous plants with big flowers room, property
Flat, slightly sweet flavor, nontoxic, return liver warp, major function have The flat liver of heat-clearing, analgesic, hemostasis, are used for treatment of arthritis, mazoitis, head
Dizzy, tinnitus, abdominal pain etc..Sunflower plate decocting liquid has the function for the treatment of tumour, and floral disc of sunflower ethanol extract has centainly
Antihypertensive effect, it is civil also use its as medical treatment atrophic gastritis herbal cuisine, while sunflower disk active peptide have treatment gout work
With, but there is presently no the sunflower disk activity peptide products used as effervescent tablet.
Summary of the invention
It is an object of the invention to: in order to fill up blank of the existing sunflower disk active peptide in effervescent tablet production, provide one
The method that kind prepares antigout plant sunflower disk extract active peptide effervescent tablet.
The technical solution adopted by the invention is as follows:
A method of preparing antigout plant sunflower disk extract active peptide effervescent tablet, comprising the following steps:
Step 1: claim to obtain following raw material: 10~20 parts of sunflower disk active peptide, 30~50 parts of gas-producing disintegrant, flavor
It 1~5 part of agent, 10~20 parts of carbohydrate, 5~20 parts of polyvinylpyrrolidone, 10~20 parts of starch, 1~5 part of magnesium stearate, eats
1~5 part of pigment, 15~30 parts of water；
Step 2: above-mentioned deal raw material being sieved respectively with 30~45 meshes, collects sieving raw material；
Step 3: active peptide, gas-producing disintegrant, starch, magnesium stearate and polyvinylpyrrolidone being mixed, convert one
The water of half deal stirs evenly, and stands 10~15min；
Step 4: surplus stock being mixed into the raw material after step 3 is stood, the water of remaining deal is added, is sufficiently stirred mixed
It closes, obtains wet feed；
Step 5: wet feed is granulated using pelletizer, preliminarily dried is passed through after the completion of being granulated, it is dry to use drier
It is dried to obtain half tide material, 80~100 DEG C of drying temperature, 5~8min of drying time；
Step 6: the half tide material after preliminarily dried being subjected to tabletting using tablet press machine and obtains semifinished product, tablet press machine revolving speed 55r/
Min, 22,000 newton of tableting pressure；
Step 7: the semifinished product that tabletting is completed finally being dried, 150~200 DEG C of drying temperature by drier, done
Dry 45~60min of time；
Step 8: the dry product that step 7 is obtained is packed to get sunflower disk active peptide effervescent tablet.
Wherein, the raw material in the step 1 specifically: 15 parts of sunflower disk active peptide, 40 parts of gas-producing disintegrant, wind
3 parts of taste agent, 10 parts of carbohydrate, 5 parts of polyvinylpyrrolidone, 12 parts of starch, 1 part of magnesium stearate, 2 parts of edible pigment, 18 parts of water.
Wherein, the acquisition methods of the sunflower disk active peptide include the following steps:
S1: sunflower disk being placed in pulverizer and is crushed, and extracting solution is then obtained by filtration；
S2: first digesting extracting solution, is then filtered using polymeric membrane, removes filter residue, obtains just liquid processed；
S3: being again passed by enzymatic hydrolysis for crude liquid, be then centrifuged using centrifuge, and the progress of duplex polymeric membrane is reused
Filtering, obtains sunflower disk active peptide.
Wherein, the starting material with water in the step 1 is deionized water.
Wherein, the step 3 and adding water and stirring in step 4 add waterside to stir, stir evenly no agglomerate for side.
Wherein, the stirring in the step 3 and step 4, is stirred under ultrasonic environment.
Wherein, the step 5 is granulated after standing 100~120min of wet feed again before being granulated.
Wherein, before the step 8 is packed, sterilization processing is carried out to dry product, sterilization processing uses radiation sterilizing.
In conclusion by adopting the above-described technical solution, the beneficial effects of the present invention are:
1, in the present invention, by raw material, stable be first divided into individually mixes twice by its nature, is mixing, is overcoming
The glutinous punching that occurs during disintegration, disintegration time is long, is also easy to produce the defect of the Character instabilities such as foam, shortens the disintegration of effervescent tablet
Time avoids foam and strength in disintegrating procedue and rushes the generation of phenomenon, while having that dissolution time is short, uses simplicity, stability
The features such as good.
2, in the present invention, by the way that flavouring agent is added, flavouring agent taste can select according to actual needs, so that effervescent tablet exists
Mouthfeel when effervesce is taken is more preferable, and user is easier to receive, and the product strength of enterprise gets a promotion.
3, in the present invention, raw material is stirred with wet concentration deionized water, and deionized water is to eliminate in water in ion shape
Pure water after formula impurity, mixing water completely namely ensure that the clean of effervescent tablet, avoid effervescent tablet by impurities in water shadow
The case where ringing, in effervesce in use, making water seem dirty, influence use feeling generation.
4, in the present invention, ultrasonic wave is used in stirring, is stirred under ultrasonic environment, ultrasonic wave carries out raw material
High-frequency vibration avoids raw material chance water agglomerating, influences to mix, and then lead to product matter so that being easier to mix between raw material
Measure affected happen.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, the present invention is carried out below further
It is described in detail.It should be appreciated that described herein, specific examples are only used to explain the present invention, is not intended to limit the present invention.
Embodiment one, a method of preparing antigout plant sunflower disk extract active peptide effervescent tablet, including following step
It is rapid:
Step 1: claim to obtain following raw material: 10~20 parts of sunflower disk active peptide, 30~50 parts of gas-producing disintegrant, flavor
It 1~5 part of agent, 10~20 parts of carbohydrate, 5~20 parts of polyvinylpyrrolidone, 10~20 parts of starch, 1~5 part of magnesium stearate, eats
1~5 part of pigment, 15~30 parts of water；
Step 2: above-mentioned deal raw material being sieved respectively with 20~30 meshes, collects sieving raw material；
Step 3: active peptide, gas-producing disintegrant, starch, magnesium stearate and polyvinylpyrrolidone being mixed, are blended into
Water stirs evenly, and stands 15~30min；
Step 4: surplus stock being mixed into the raw material after step 3 is stood, is thoroughly mixed, wet feed is obtained, is stood wet
Expect 100~120min；
Step 5: wet feed is granulated using pelletizer, preliminarily dried is passed through after the completion of being granulated, it is dry to use drier
It is dried to obtain half tide material, 80~100 DEG C of drying temperature, 5~10min of drying time；
Step 6: the half tide material after preliminarily dried being subjected to tabletting using tablet press machine and obtains semifinished product, tablet press machine revolving speed 55r/
Min, 20,000 newton of tableting pressure；
Step 7: the semifinished product that tabletting is completed finally being dried, 150~200 DEG C of drying temperature by drier, done
Dry 45~60min of time；
Step 8: the dry product that step 7 is obtained is packed to get sunflower disk active peptide effervescent tablet.
Raw material in the step 1 specifically: 15 parts of sunflower disk active peptide, 40 parts of gas-producing disintegrant, flavouring agent 3
Part, 10 parts of carbohydrate, 5 parts of polyvinylpyrrolidone, 12 parts of starch, 1 part of magnesium stearate, 2 parts of edible pigment, 18 parts of water.
The step 3 and adding water and stirring in step 4 add waterside to stir for side, stir evenly no agglomerate, while stirring
It is stirred under ultrasonic environment.
Before the step 8 is packed, sterilization processing is carried out to dry product, sterilization processing uses radiation sterilizing.
Embodiment two, a method of preparing antigout plant sunflower disk extract active peptide effervescent tablet, including following step
It is rapid:
Step 1: claim to obtain following raw material: 10~20 parts of sunflower disk active peptide, 30~50 parts of gas-producing disintegrant, flavor
It 1~5 part of agent, 10~20 parts of carbohydrate, 5~20 parts of polyvinylpyrrolidone, 10~20 parts of starch, 1~5 part of magnesium stearate, eats
1~5 part of pigment, 15~30 parts of deionized water；
Step 2: above-mentioned deal raw material being sieved respectively with 40~50 meshes, collects sieving raw material；
Step 3: active peptide, gas-producing disintegrant, starch, magnesium stearate and polyvinylpyrrolidone being mixed, are blended into
Deionized water stirs evenly, and stands 30~45min；
Step 4: surplus stock being mixed into the raw material after step 3 is stood, is thoroughly mixed, obtains wet feed；
Step 5: wet feed is granulated using pelletizer, preliminarily dried is passed through after the completion of being granulated, it is dry to use drier
It is dried to obtain half tide material, 80~100 DEG C of drying temperature, 5~8min of drying time；
Step 6: the half tide material after preliminarily dried being subjected to tabletting using tablet press machine and obtains semifinished product, tablet press machine revolving speed 55r/
Min, 20,000 newton of tableting pressure；
Step 7: the semifinished product that tabletting is completed finally being dried, 150~200 DEG C of drying temperature by drier, done
Dry 55~65min of time；
Step 8: the dry product that step 7 is obtained is packed to get sunflower disk active peptide effervescent tablet.
Raw material in the step 1 specifically: 15 parts of sunflower disk active peptide, 40 parts of gas-producing disintegrant, flavouring agent 3
Part, 10 parts of carbohydrate, 5 parts of polyvinylpyrrolidone, 12 parts of starch, 1 part of magnesium stearate, 2 parts of edible pigment, 18 parts of deionized water.
The step 3 and adding water and stirring in step 4 add waterside to stir, stir evenly no agglomerate, stir in ultrasound for side
It is stirred under wave environment.
The step 5 is granulated after standing 100~120min of wet feed again before being granulated.
Before the step 8 is packed, sterilization processing is carried out to dry product, sterilization processing uses radiation sterilizing, irradiatometer
Measure 25kGy, 70 DEG C of irradiation temperature, irradiation time 15min.
Embodiment three, a method of preparing antigout plant sunflower disk extract active peptide effervescent tablet, including following step
It is rapid:
Step 1: claim to obtain following raw material: 10~20 parts of sunflower disk active peptide, 30~50 parts of gas-producing disintegrant, flavor
It 1~5 part of agent, 10~20 parts of carbohydrate, 5~20 parts of polyvinylpyrrolidone, 10~20 parts of starch, 1~5 part of magnesium stearate, eats
1~5 part of pigment, 15~30 parts of deionized water；
Step 2: above-mentioned deal raw material being sieved respectively with 35~45 meshes, collects sieving raw material；
Step 3: active peptide, gas-producing disintegrant, starch, magnesium stearate and polyvinylpyrrolidone being mixed, converted
Ionized water stirs evenly, and stands 15~30min；
Step 4: surplus stock being mixed into the raw material after step 3 is stood, is thoroughly mixed, obtains wet feed；
Step 5: wet feed is granulated using pelletizer, preliminarily dried is passed through after the completion of being granulated, it is dry to use drier
It is dried to obtain half tide material, 80~100 DEG C of drying temperature, 5~8min of drying time；
Step 6: the half tide material after preliminarily dried being subjected to tabletting using tablet press machine and obtains semifinished product, tablet press machine revolving speed 55r/
Min, 25,000 newton of tableting pressure；
Step 7: the semifinished product that tabletting is completed finally being dried, 150~200 DEG C of drying temperature by drier, done
Dry 45~60min of time；
Step 8: the dry product that step 7 is obtained is packed to get sunflower disk active peptide effervescent tablet.
Specifically, the raw material in the step 1 specifically: 15 parts of sunflower disk active peptide, 40 parts of gas-producing disintegrant,
3 parts of flavouring agent, 10 parts of carbohydrate, 5 parts of polyvinylpyrrolidone, 12 parts of starch, 1 part of magnesium stearate, 2 parts of edible pigment, deionization
18 parts of water.
The acquisition methods of the sunflower disk active peptide include the following steps:
S1: sunflower disk being placed in pulverizer and is crushed, and extracting solution is then obtained by filtration；
S2: first digesting extracting solution, is then filtered using polymeric membrane, removes filter residue, obtains just liquid processed；
S3: being again passed by enzymatic hydrolysis for crude liquid, be then centrifuged using centrifuge, and the progress of duplex polymeric membrane is reused
Filtering, obtains sunflower disk active peptide.
The step 3 and adding water and stirring in step 4 add waterside to stir for side, stir evenly no agglomerate, and stirring is super
It is stirred under sound wave environment.
The step 5 is granulated after standing 100~120min of wet feed again before being granulated.
Before the step 8 is packed, sterilization processing is carried out to dry product, sterilization processing uses radiation sterilizing.
Example IV, a method of preparing antigout plant sunflower disk extract active peptide effervescent tablet, including following step
It is rapid:
Step 1: claim to obtain following raw material: 10~20 parts of sunflower disk active peptide, 30~50 parts of gas-producing disintegrant, flavor
It 1~5 part of agent, 10~20 parts of carbohydrate, 5~20 parts of polyvinylpyrrolidone, 10~20 parts of starch, 1~5 part of magnesium stearate, eats
1~5 part of pigment, 15~30 parts of deionized water；
Step 2: above-mentioned deal raw material being sieved respectively with 30~45 meshes, collects sieving raw material；
Step 3: active peptide, gas-producing disintegrant, starch, magnesium stearate and polyvinylpyrrolidone being mixed, convert one
The deionized water of half deal stirs evenly, and stands 10~15min；
Step 4: surplus stock being mixed into the raw material after step 3 is stood, the deionized water of remaining deal is added, sufficiently stirs
Mixing is mixed, wet feed is obtained；
Step 5: wet feed is granulated using pelletizer, preliminarily dried is passed through after the completion of being granulated, it is dry to use drier
It is dried to obtain half tide material, 80~100 DEG C of drying temperature, 5~8min of drying time；
Step 6: the half tide material after preliminarily dried being subjected to tabletting using tablet press machine and obtains semifinished product, tablet press machine revolving speed 55r/
Min, 22,000 newton of tableting pressure；
Step 7: the semifinished product that tabletting is completed finally being dried, 150~200 DEG C of drying temperature by drier, done
Dry 45~60min of time；
Step 8: the dry product that step 7 is obtained is packed to get sunflower disk active peptide effervescent tablet.
Specifically, the raw material in the step 1 specifically: 15 parts of sunflower disk active peptide, 40 parts of gas-producing disintegrant,
3 parts of flavouring agent, 10 parts of carbohydrate, 5 parts of polyvinylpyrrolidone, 12 parts of starch, 1 part of magnesium stearate, 2 parts of edible pigment, deionization
18 parts of water.
The acquisition methods of the sunflower disk active peptide include the following steps:
S1: sunflower disk being placed in pulverizer and is crushed, and extracting solution is then obtained by filtration；
S2: first digesting extracting solution, is then filtered using polymeric membrane, removes filter residue, obtains just liquid processed；
S3: being again passed by enzymatic hydrolysis for crude liquid, be then centrifuged using centrifuge, and the progress of duplex polymeric membrane is reused
Filtering, obtains sunflower disk active peptide.
The step 3 and adding water and stirring in step 4 add waterside to stir for side, stir evenly no agglomerate, and stirring is super
It is stirred under sound wave environment.
The step 5 is granulated after standing 100~120min of wet feed again before being granulated.
Before the step 8 is packed, sterilization processing is carried out to dry product, sterilization processing uses radiation sterilizing.
Embodiment five, a method of preparing antigout plant sunflower disk extract active peptide effervescent tablet, including following step
It is rapid:
Step 1: claim to obtain following raw material: 10~20 parts of sunflower disk active peptide, 30~50 parts of gas-producing disintegrant, flavor
It 1~5 part of agent, 10~20 parts of carbohydrate, 5~20 parts of polyvinylpyrrolidone, 10~20 parts of starch, 1~5 part of magnesium stearate, eats
1~5 part of pigment, 15~30 parts of deionized water；
Step 2: above-mentioned deal raw material being sieved respectively with 30~45 meshes, collects sieving raw material；
Step 3: active peptide, gas-producing disintegrant, starch, magnesium stearate and polyvinylpyrrolidone being mixed, convert one
The deionized water of half deal stirs evenly, and stands 10~15min；
Step 4: surplus stock being mixed into the raw material after step 3 is stood, the deionized water of remaining deal is added, sufficiently stirs
Mixing is mixed, wet feed is obtained；
Step 5: wet feed is granulated using pelletizer, preliminarily dried is passed through after the completion of being granulated, it is dry to use drier
It is dried to obtain half tide material, 80~100 DEG C of drying temperature, 5~8min of drying time；
Step 6: the half tide material after preliminarily dried being subjected to tabletting using tablet press machine and obtains semifinished product, tablet press machine revolving speed 55r/
Min, 22,000 newton of tableting pressure；
Step 7: the semifinished product that tabletting is completed finally being dried, 150~200 DEG C of drying temperature by drier, done
Dry 45~60min of time；
Step 8: the dry product that step 7 is obtained is packed to get sunflower disk active peptide effervescent tablet.
Raw material in the step 1 specifically: 15 parts of sunflower disk active peptide, 40 parts of gas-producing disintegrant, flavouring agent 3
Part, 10 parts of carbohydrate, 5 parts of polyvinylpyrrolidone, 12 parts of starch, 1 part of magnesium stearate, 2 parts of edible pigment, 18 parts of deionized water.
The acquisition methods of the sunflower disk active peptide include the following steps:
S1: sunflower disk being placed in pulverizer and is crushed, and extracting solution is then obtained by filtration；
S2: first digesting extracting solution, is then filtered using polymeric membrane, removes filter residue, obtains just liquid processed；
S3: being again passed by enzymatic hydrolysis for crude liquid, be then centrifuged using centrifuge, and the progress of duplex polymeric membrane is reused
Filtering, enzymatic hydrolysis are digested using enzymatic vessel, and enzymatic hydrolysis is that trypsase, neutral proteinase and elastoser are combined into enzyme
Compound protease；
S4: repeat S3 step three times to get arrive sunflower disk active peptide.
The step 3 and adding water and stirring in step 4 add waterside to stir, stir evenly no agglomerate for side.
The step 5 is granulated after standing 100~120min of wet feed again before being granulated.
Before the step 8 is packed, sterilization processing is carried out to dry product, sterilization processing uses radiation sterilizing.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within mind and principle.
Claims (8)
1. a kind of method for preparing antigout plant sunflower disk extract active peptide effervescent tablet, which is characterized in that including following step
It is rapid:
Step 1: claim to obtain following raw material: 10~20 parts of sunflower disk active peptide, 30~50 parts of gas-producing disintegrant, flavouring agent 1
~5 parts, 10~20 parts of carbohydrate, 5~20 parts of polyvinylpyrrolidone, 10~20 parts of starch, 1~5 part of magnesium stearate, edible pigment
1~5 part, 15~30 parts of water；
Step 2: above-mentioned deal raw material being sieved respectively with 30~45 meshes, collects sieving raw material；
Step 3: active peptide, gas-producing disintegrant, starch, magnesium stearate and polyvinylpyrrolidone being mixed, a moiety is converted
The water of amount stirs evenly, and stands 10~15min；
Step 4: surplus stock being mixed into the raw material after step 3 is stood, the water of remaining deal is added, is thoroughly mixed, obtains
To wet feed；
Step 5: wet feed being granulated using pelletizer, preliminarily dried is passed through after the completion of being granulated, drying is carried out using drier
Dry half tide material, 80~100 DEG C of drying temperature, 5~8min of drying time；
Step 6: the half tide material after preliminarily dried being subjected to tabletting using tablet press machine and obtains semifinished product, tablet press machine revolving speed 55r/min, pressure
22,000 newton of piece pressure；
Step 7: the semifinished product that tabletting is completed finally being dried by drier, 150~200 DEG C of drying temperature, when dry
Between 45~60min；
Step 8: the dry product that step 7 is obtained is packed to get sunflower disk active peptide effervescent tablet.
2. a kind of method for preparing antigout plant sunflower disk extract active peptide effervescent tablet as described in claim 1, special
Sign is, the raw material in the step 1 specifically: 15 parts of sunflower disk active peptide, 40 parts of gas-producing disintegrant, and flavouring agent 3
Part, 10 parts of carbohydrate, 5 parts of polyvinylpyrrolidone, 12 parts of starch, 1 part of magnesium stearate, 2 parts of edible pigment, 18 parts of water.
3. a kind of method for preparing antigout plant sunflower disk extract active peptide effervescent tablet as claimed in claim 2, special
Sign is that the acquisition methods of the sunflower disk active peptide include the following steps:
S1: sunflower disk being placed in pulverizer and is crushed, and extracting solution is then obtained by filtration；
S2: first digesting extracting solution, is then filtered using polymeric membrane, removes filter residue, obtains just liquid processed；
S3: being again passed by enzymatic hydrolysis for crude liquid, be then centrifuged using centrifuge, is reused duplex polymeric membrane and was carried out
Filter, obtains sunflower disk active peptide.
4. a kind of method for preparing antigout plant sunflower disk extract active peptide effervescent tablet as claimed in claim 2, special
Sign is that the starting material with water in the step 1 is deionized water.
5. a kind of method for preparing antigout plant sunflower disk extract active peptide effervescent tablet as described in claim 1, special
Sign is that the step 3 and adding water and stirring in step 4 add waterside to stir, stir evenly no agglomerate for side.
6. a kind of method for preparing antigout plant sunflower disk extract active peptide effervescent tablet as claimed in claim 5, special
Sign is that the stirring in the step 3 and step 4, is stirred under ultrasonic environment.
7. a kind of method for preparing antigout plant sunflower disk extract active peptide effervescent tablet as described in claim 1, special
Sign is that the step 5 is granulated after standing 100~120min of wet feed again before being granulated.
8. a kind of method for preparing antigout plant sunflower disk extract active peptide effervescent tablet as described in claim 1, special
Sign is, before the step 8 is packed, carries out sterilization processing to dry product, sterilization processing uses radiation sterilizing.
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| CN201910602111.2A CN110404046A (en) | 2019-07-05 | 2019-07-05 | A method of preparing antigout plant sunflower disk extract active peptide effervescent tablet |
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| CN201910602111.2A CN110404046A (en) | 2019-07-05 | 2019-07-05 | A method of preparing antigout plant sunflower disk extract active peptide effervescent tablet |
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