CN107361281B - Momordica grosvenori effervescent tablet and preparation method thereof - Google Patents
Momordica grosvenori effervescent tablet and preparation method thereof Download PDFInfo
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- CN107361281B CN107361281B CN201710568510.2A CN201710568510A CN107361281B CN 107361281 B CN107361281 B CN 107361281B CN 201710568510 A CN201710568510 A CN 201710568510A CN 107361281 B CN107361281 B CN 107361281B
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- 235000011171 Thladiantha grosvenorii Nutrition 0.000 title claims abstract description 64
- 239000007938 effervescent tablet Substances 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 241001409321 Siraitia grosvenorii Species 0.000 title claims abstract 19
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 51
- 239000000284 extract Substances 0.000 claims abstract description 46
- 229960001021 lactose monohydrate Drugs 0.000 claims abstract description 17
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 claims abstract description 15
- 239000008118 PEG 6000 Substances 0.000 claims abstract description 15
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 claims abstract description 15
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims abstract description 12
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
- 238000002156 mixing Methods 0.000 claims description 24
- 238000007873 sieving Methods 0.000 claims description 18
- 238000001035 drying Methods 0.000 claims description 15
- 238000000605 extraction Methods 0.000 claims description 13
- 238000010992 reflux Methods 0.000 claims description 13
- 229960002303 citric acid monohydrate Drugs 0.000 claims description 12
- 238000001914 filtration Methods 0.000 claims description 12
- 239000002994 raw material Substances 0.000 claims description 10
- 238000001816 cooling Methods 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 7
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 7
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 7
- 235000019441 ethanol Nutrition 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 229960004106 citric acid Drugs 0.000 claims description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M sodium bicarbonate Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 5
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims 3
- 235000017557 sodium bicarbonate Nutrition 0.000 claims 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 2
- 229940069328 povidone Drugs 0.000 claims 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 claims 1
- 239000007968 orange flavor Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 abstract description 25
- 229920003081 Povidone K 30 Polymers 0.000 abstract description 4
- 235000016709 nutrition Nutrition 0.000 abstract description 4
- 230000035764 nutrition Effects 0.000 abstract description 4
- 229940024898 povidone k30 Drugs 0.000 abstract description 4
- 239000007884 disintegrant Substances 0.000 abstract description 2
- 230000001050 lubricating effect Effects 0.000 abstract description 2
- 244000185386 Thladiantha grosvenorii Species 0.000 description 45
- 235000013399 edible fruits Nutrition 0.000 description 6
- 235000013361 beverage Nutrition 0.000 description 5
- 239000000047 product Substances 0.000 description 4
- 244000269722 Thea sinensis Species 0.000 description 3
- 239000006189 buccal tablet Substances 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000012634 fragment Substances 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 238000010791 quenching Methods 0.000 description 3
- 230000000171 quenching effect Effects 0.000 description 3
- 238000002390 rotary evaporation Methods 0.000 description 3
- 239000006188 syrup Substances 0.000 description 3
- 235000020357 syrup Nutrition 0.000 description 3
- 230000035922 thirst Effects 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 241000287420 Pyrus x nivalis Species 0.000 description 2
- 206010044302 Tracheitis Diseases 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000014347 soups Nutrition 0.000 description 2
- 235000013616 tea Nutrition 0.000 description 2
- 238000005550 wet granulation Methods 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 241000205585 Aquilegia canadensis Species 0.000 description 1
- 244000012254 Canarium album Species 0.000 description 1
- 235000009103 Canarium album Nutrition 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 241000219104 Cucurbitaceae Species 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 244000303040 Glycyrrhiza glabra Species 0.000 description 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 201000005702 Pertussis Diseases 0.000 description 1
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 206010001093 acute tonsillitis Diseases 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 229960000250 adipic acid Drugs 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 235000012970 cakes Nutrition 0.000 description 1
- 235000014510 cooky Nutrition 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 201000005577 familial hyperlipidemia Diseases 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 229960001375 lactose Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 235000011477 liquorice Nutrition 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 1
- 235000021395 porridge Nutrition 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 235000013547 stew Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960001367 tartaric acid Drugs 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
- A23L2/395—Dry compositions in a particular shape or form
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/40—Effervescence-generating compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the field of pharmacy, and discloses a momordica grosvenori effervescent tablet which comprises the following components in parts by weight: 100-250 parts of fructus momordicae extract, 100-250 parts of sodium bicarbonate, 200-500 parts of citric acid, 200-500 parts of lactose monohydrate, 40-100 parts of PEG6000, 30-80 parts of povidone k30 and 5-20 parts of orange essence. The invention also discloses a preparation method of the momordica grosvenori effervescent tablet. The momordica grosvenori effervescent tablet has the characteristics of simple process, novel form, nutrition, health care and convenience in carrying. According to the invention, the PEG6000 is adopted to melt and wrap the sodium bicarbonate, and the citric acid part is separately granulated, so that the effervescent disintegrant is separated, the PEG6000 plays a certain lubricating role, the tabletting process can be smoothly carried out, and the obtained tablet is flat and smooth and has uniform color.
Description
Technical Field
The invention belongs to the field of pharmacy, and particularly relates to a momordica grosvenori effervescent tablet and a preparation method thereof.
Background
Momordica grosvenori, the fruit of perennial vine plants of the cucurbitaceae family, is known as "immortal fruit" by people and is one of the first approved medicinal and edible materials in China.
The traditional Chinese medicine holds that the momordica grosvenori is sweet, sour and cool in nature, and has the effects of clearing heat, relieving summer-heat, reducing phlegm, relieving cough, cooling blood, relaxing bones, clearing lung, moistening intestines, promoting the production of body fluid, quenching thirst and the like; can be used for treating acute and chronic tracheitis, pharyngolaryngitis, bronchial asthma, pertussis, stomach heat, constipation, and acute tonsillitis.
Modern medical research proves that the momordica grosvenori contains 300 times of sweetner than sucrose, but does not generate heat, so that the momordica grosvenori is an ideal substitute beverage for people who are not suitable for eating sugar, such as diabetes mellitus, obesity and the like. Fructus Siraitiae Grosvenorii contains abundant vitamin C, and has antiaging, anticancer, skin caring and skin caring effects; has the functions of reducing blood fat and losing weight, can assist in treating hyperlipemia and improving the image of obese people, and is a necessary fruit for women loving beauty.
The fructus Siraitiae Grosvenorii can be made into fructus Siraitiae Grosvenorii tea, fructus Siraitiae Grosvenorii candy beverage, fructus Siraitiae Grosvenorii fructus Jujubae tea, fructus Siraitiae Grosvenorii herba Houttuyniae, fructus Siraitiae Grosvenorii herba Leonuri soup, fructus Siraitiae Grosvenorii semen oryzae Sativae porridge, fructus Siraitiae Grosvenorii snow pear beverage, fructus Siraitiae Grosvenorii fructus fici. Fructus Siraitiae Grosvenorii can also be used as flavoring agent for stew, clear soup, cake, candy, and cookies. Besides the dry fruit, the product also includes infusion, syrup, fruit extract, cough syrup and concentrated fruit syrup.
At present, the products of the momordica grosvenori in the market mainly comprise momordica grosvenori fructose, momordica grosvenori green tea granules, momordica grosvenori snow pear paste, momordica grosvenori buccal tablets, honeysuckle momordica grosvenori buccal tablets, liquorice, momordica grosvenori and fructus mume and Chinese olive buccal tablets and the like. Patent CN102283417A discloses a fructus momordicae effervescent tablet and a preparation process thereof, wherein fructus momordicae extract, tartaric acid, lactose, sodium bicarbonate, adipic acid and stevioside are mixed uniformly, and the mixture is dried and tabletted after wet granulation.
Disclosure of Invention
The invention aims to provide a momordica grosvenori effervescent tablet and a preparation method thereof, and the momordica grosvenori effervescent tablet is prepared by wet granulation and pressing, wherein the momordica grosvenori effervescent tablet contains momordica grosvenori extract, sodium bicarbonate, citric acid, lactose monohydrate, PEG6000, povidone k30 and orange essence.
The purpose of the invention is realized by the following technical scheme:
the momordica grosvenori effervescent tablet comprises the following components in parts by weight:
preferably, the momordica grosvenori effervescent tablet comprises the following components in parts by weight:
further preferably, the momordica grosvenori effervescent tablets comprise the following components in parts by weight:
still further preferably, the momordica grosvenori effervescent tablets comprise the following components in parts by weight:
the invention also aims to provide a preparation method of the momordica grosvenori effervescent tablet, which comprises the following steps:
(1) crushing a raw material of momordica grosvenori, adding water with the weight 6-8 times that of momordica grosvenori, performing reflux extraction for 2-3 hours, repeating the reflux extraction for 1-3 times, filtering, combining water extract, adding absolute ethyl alcohol into the water extract until the concentration of the ethanol is 60%, standing overnight, filtering, concentrating the filtrate to obtain a thick extract, and drying to obtain a momordica grosvenori extract;
(2) heating PEG6000 (polyethylene glycol 6000) to melt, adding sodium bicarbonate, mixing, cooling to room temperature, pulverizing, and sieving with 80 mesh sieve;
(3) sieving fructus Siraitiae Grosvenorii extract, citric acid, and lactose monohydrate with 80 mesh sieve respectively; mixing fructus Siraitiae Grosvenorii extract, citric acid, and lactose monohydrate, adding 10 (w/v)% povidone k30 anhydrous ethanol solution to make soft mass, sieving with 26 mesh sieve, granulating, drying, and grading;
(4) and (3) mixing the materials obtained in the steps (2) and (3), adding orange essence, uniformly mixing, and tabletting to obtain the momordica grosvenori effervescent tablet.
Preferably, in the step (1), the momordica grosvenori raw material is crushed, added with water with the weight 6-8 times of that of the momordica grosvenori raw material for reflux extraction for 2-3h, repeated for 2 times, filtered, and the water extract is combined.
Compared with the prior art, the invention has the beneficial effects that:
the momordica grosvenori effervescent tablet has the characteristics of simple process, novel form, nutrition, health care and convenience in carrying. Aiming at the current development situation of beverage industry at home and abroad and the current application situation of the momordica grosvenori, the inventor develops the momordica grosvenori effervescent tablet, namely the novel gas-producing beverage tablet, and the momordica grosvenori effervescent tablet can be loaded with beneficial components reasonably according to the needs of human bodies, thereby quenching thirst and supplementing nutrition reasonably. The product integrates five functions of nutrition, delicacy, health care, thirst quenching and novelty, and is a novel product with low cost and high added value. According to the invention, the PEG6000 is adopted to melt and wrap the sodium bicarbonate, and the citric acid part is separately granulated, so that the effervescent disintegrant is separated, the PEG6000 plays a certain lubricating role, the tabletting process can be smoothly carried out, and the obtained tablet is flat and smooth and has uniform color.
Detailed Description
The following examples further illustrate the technical solutions of the present invention, but should not be construed as limiting the present invention.
Example 1
A fructus momordicae effervescent tablet is 0.8g per tablet, and each tablet comprises the following components in percentage by weight:
the preparation method comprises the following steps:
(1) crushing a momordica grosvenori raw material, adding 8 times of water by weight, performing reflux extraction for 3 hours, repeating the reflux extraction for 2 times, filtering, combining water extract, adding absolute ethyl alcohol into the water extract until the concentration of the ethanol is 60%, standing overnight, filtering, performing rotary evaporation and concentration on the filtrate to obtain a thick extract, and drying in a drying oven to obtain a momordica grosvenori extract;
(2) heating PEG6000 to melt, adding sodium bicarbonate, mixing uniformly, cooling to room temperature, crushing, and sieving with a 80-mesh sieve;
(3) sieving fructus Siraitiae Grosvenorii extract, citric acid, and lactose monohydrate with 80 mesh sieve respectively; (ii) a Mixing fructus Siraitiae Grosvenorii extract, citric acid, and lactose monohydrate, adding 10 (w/v)% povidone k30 anhydrous ethanol solution to make soft mass, sieving with 26 mesh sieve, granulating, drying, and grading;
(4) and (3) mixing the materials obtained in the steps (2) and (3), adding orange essence, uniformly mixing, and tabletting to obtain the momordica grosvenori effervescent tablet.
The disintegration time limit inspection method of the effervescent tablets is as follows according to appendix XA of the second part of Chinese pharmacopoeia 2010 edition: taking 1 tablet, placing into 250ml beaker, each beaker containing 200ml water at 15-25 deg.C, releasing many bubbles, and dissolving or dispersing in water when gas around tablet or fragment stops escaping, without residual aggregated particles. Unless otherwise specified, 6 tablets were examined as above and each tablet should disintegrate within 5 min. If 1 tablet can not be completely disintegrated, 6 tablets should be taken for retesting, and all the results are in accordance with the regulations.
The detection results are as follows:
example 2
The momordica grosvenori effervescent tablet is 1.2g per tablet, and each momordica grosvenori effervescent tablet comprises the following components in percentage by weight:
the preparation method comprises the following steps:
(1) crushing a momordica grosvenori raw material, adding 6 times of water by weight, performing reflux extraction for 2 hours, repeating the reflux extraction for 2 times, filtering, combining water extract, adding absolute ethyl alcohol into the water extract until the concentration of the ethanol is 60%, standing overnight, filtering, performing rotary evaporation and concentration on the filtrate to obtain a thick extract, and drying in a drying oven to obtain a momordica grosvenori extract;
(2) heating PEG6000 to melt, adding sodium bicarbonate, mixing uniformly, cooling to room temperature, crushing, and sieving with a 80-mesh sieve;
(3) sieving fructus Siraitiae Grosvenorii extract, citric acid, and lactose monohydrate with 80 mesh sieve respectively; mixing fructus Siraitiae Grosvenorii extract, citric acid, and lactose monohydrate, adding 10% polyvidone k30 anhydrous alcohol solution (w/v) to make soft mass, sieving with 26 mesh sieve, granulating, drying, and grading;
(4) and (3) mixing the materials obtained in the steps (2) and (3), adding orange essence, uniformly mixing, and tabletting to obtain the momordica grosvenori effervescent tablet.
The disintegration time limit inspection method of the effervescent tablets is as follows according to appendix XA of the second part of Chinese pharmacopoeia 2010 edition: taking 1 tablet, placing into 250ml beaker, each beaker containing 200ml water at 15-25 deg.C, releasing many bubbles, and dissolving or dispersing in water when gas around tablet or fragment stops escaping, without residual aggregated particles. Unless otherwise specified, 6 tablets were examined as above and each tablet should disintegrate within 5 min. If 1 tablet can not be completely disintegrated, 6 tablets should be taken for retesting, and all the results are in accordance with the regulations.
The detection results are as follows:
example 3
A momordica grosvenori effervescent tablet is 1.5g per tablet, and each momordica grosvenori effervescent tablet comprises the following components in percentage by weight:
the preparation method comprises the following steps:
(1) crushing a momordica grosvenori raw material, adding 6 times of water by weight, performing reflux extraction for 2 hours, repeating the reflux extraction for 2 times, filtering, combining water extract, adding absolute ethyl alcohol into the water extract until the concentration of the ethanol is 60%, standing overnight, filtering, performing rotary evaporation and concentration on the filtrate to obtain a thick extract, drying the thick extract in a drying oven, and crushing to obtain a momordica grosvenori extract;
(2) heating PEG6000 to melt, adding sodium bicarbonate, mixing uniformly, cooling to room temperature, crushing, and sieving with a 80-mesh sieve;
(3) sieving fructus Siraitiae Grosvenorii extract, citric acid, and lactose monohydrate with 80 mesh sieve respectively; mixing fructus Siraitiae Grosvenorii extract, citric acid, and lactose monohydrate, adding 10% polyvidone k30 anhydrous alcohol solution (w/v) to make soft mass, sieving with 26 mesh sieve, granulating, drying, and grading;
(4) and (3) mixing the materials obtained in the steps (2) and (3), adding orange essence, uniformly mixing, and tabletting to obtain the momordica grosvenori effervescent tablet.
The disintegration time limit inspection method of the effervescent tablets is as follows according to appendix XA of the second part of Chinese pharmacopoeia 2010 edition: taking 1 tablet, placing into 250ml beaker, each beaker containing 200ml water at 15-25 deg.C, releasing many bubbles, and dissolving or dispersing in water when gas around tablet or fragment stops escaping, without residual aggregated particles. Unless otherwise specified, 6 tablets were examined as above and each tablet should disintegrate within 5 min. If 1 tablet can not be completely disintegrated, 6 tablets should be taken for retesting, and all the results are in accordance with the regulations.
The detection results are as follows:
the above description is only a basic description of the present invention, and any equivalent changes made according to the technical solution of the present invention should fall within the protection scope of the present invention.
Claims (5)
1. The momordica grosvenori effervescent tablet is characterized by comprising the following components in parts by weight:
the components in parts by weight
Fructus momordicae extract 120-
Sodium bicarbonate 120-
Citric acid 240-450-
Lactose monohydrate 240-
PEG 6000 40-75
Povidone k 3035-60
5-15 parts of orange essence;
the momordica grosvenori effervescent tablet is prepared by the following preparation method:
(1) crushing a momordica grosvenori raw material, adding 6-8 times of water by weight, performing reflux extraction for 2-3 hours, repeating the reflux extraction for 1-3 times, filtering, combining water extract, adding absolute ethyl alcohol into the water extract until the concentration of the ethanol is 60%, standing overnight, filtering, concentrating the filtrate to obtain a thick extract, and drying to obtain a momordica grosvenori extract;
(2) heating PEG6000 to melt, adding sodium bicarbonate, mixing uniformly, cooling to room temperature, crushing, and sieving with a 80-mesh sieve;
(3) sieving fructus Siraitiae Grosvenorii extract, citric acid, and lactose monohydrate with 80 mesh sieve respectively; mixing fructus Siraitiae Grosvenorii extract, citric acid, and lactose monohydrate, adding 10w/v% polyvidone k30 anhydrous alcohol solution to make soft mass, sieving with 26 mesh sieve, granulating, drying, and grading;
(4) and (3) mixing the materials obtained in the steps (2) and (3), adding orange essence, uniformly mixing, and tabletting to obtain the momordica grosvenori effervescent tablet.
2. The momordica grosvenori effervescent tablet according to claim 1, wherein the momordica grosvenori effervescent tablet comprises the following components in parts by weight:
the components in parts by weight
180 pieces of fructus momordicae extract
Sodium bicarbonate 180-
Citric acid 350-
Lactose monohydrate 300-
PEG 6000 45-60
Polyvidone k 3035-50
8-12 parts of orange essence.
3. The momordica grosvenori effervescent tablet according to claim 2, wherein the momordica grosvenori effervescent tablet comprises the following components in parts by weight:
the components in parts by weight
Lo Han Guo extract 190
Sodium bicarbonate 190
Citric acid 380
Lactose monohydrate 340
PEG 6000 50
Povidone k 3040
Orange flavor 10.
4. A method for preparing momordica grosvenori effervescent tablets according to claim 1, which comprises the following steps:
(1) crushing a momordica grosvenori raw material, adding 6-8 times of water by weight, performing reflux extraction for 2-3 hours, repeating the reflux extraction for 1-3 times, filtering, combining water extract, adding absolute ethyl alcohol into the water extract until the concentration of the ethanol is 60%, standing overnight, filtering, concentrating the filtrate to obtain a thick extract, and drying to obtain a momordica grosvenori extract;
(2) heating PEG6000 to melt, adding sodium bicarbonate, mixing uniformly, cooling to room temperature, crushing, and sieving with a 80-mesh sieve;
(3) sieving fructus Siraitiae Grosvenorii extract, citric acid, and lactose monohydrate with 80 mesh sieve respectively; mixing fructus Siraitiae Grosvenorii extract, citric acid, and lactose monohydrate, adding 10w/v% polyvidone k30 anhydrous alcohol solution to make soft mass, sieving with 26 mesh sieve, granulating, drying, and grading;
(4) and (3) mixing the materials obtained in the steps (2) and (3), adding orange essence, uniformly mixing, and tabletting to obtain the momordica grosvenori effervescent tablet.
5. The preparation method of the momordica grosvenori effervescent tablet according to claim 4, wherein in the step (1), the momordica grosvenori raw material is crushed, added with water with the weight of 6-8 times of the weight of the raw material, refluxed and extracted for 2-3 hours, repeated for 2 times, filtered, and the water extract is combined.
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| CN102302117A (en) * | 2011-06-27 | 2012-01-04 | 桂林中族中药股份有限公司 | Momordica grosvenori vitamin C effervescent tablets and preparation process thereof |
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| CN102429888A (en) * | 2011-12-30 | 2012-05-02 | 湖南农业大学 | Water-soluble resveratrol effervescent tablet and preparation method thereof |
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| CN102008556A (en) * | 2009-09-08 | 2011-04-13 | 河南惠通天下动物药业有限公司 | Qiqing Baidu effervescent granule and preparation method thereof |
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