CN101862399B - Medicine for preventing and treating pediatric saprodontia and preparation method thereof - Google Patents
Medicine for preventing and treating pediatric saprodontia and preparation method thereof Download PDFInfo
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- CN101862399B CN101862399B CN2010102103216A CN201010210321A CN101862399B CN 101862399 B CN101862399 B CN 101862399B CN 2010102103216 A CN2010102103216 A CN 2010102103216A CN 201010210321 A CN201010210321 A CN 201010210321A CN 101862399 B CN101862399 B CN 101862399B
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- 235000009569 green tea Nutrition 0.000 claims abstract description 8
- 241000555682 Forsythia x intermedia Species 0.000 claims abstract description 3
- 241000628997 Flos Species 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 7
- 241000245240 Lonicera Species 0.000 claims description 4
- 241000207929 Scutellaria Species 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 4
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- 238000010438 heat treatment Methods 0.000 claims description 3
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
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- 235000008658 Artemisia capillaris Nutrition 0.000 abstract 1
- 241000092668 Artemisia capillaris Species 0.000 abstract 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 abstract 1
- 244000020518 Carthamus tinctorius Species 0.000 abstract 1
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- 235000014220 Rhus chinensis Nutrition 0.000 abstract 1
- 240000003152 Rhus chinensis Species 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 235000012907 honey Nutrition 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 9
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 8
- 208000002925 dental caries Diseases 0.000 description 8
- 241000186044 Actinomyces viscosus Species 0.000 description 7
- 230000001580 bacterial effect Effects 0.000 description 7
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- 238000007689 inspection Methods 0.000 description 4
- 229920001817 Agar Polymers 0.000 description 3
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 3
- 241001149563 Streptococcus mutans ATCC 25175 Species 0.000 description 3
- 239000008272 agar Substances 0.000 description 3
- 230000001013 cariogenic effect Effects 0.000 description 3
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Abstract
The invention relates to medicine for preventing and treating pediatric saprodontia, which belongs to a medical agent prepared from the following raw medicine by weight parts: 4 to 8 parts of radix scutellariae, 6 to 10 parts of magnolia officinalis, 1 to 5 parts of forsythia, 1 to 3 parts of capillary artemisia, 1 to 5 parts of nutgall, 3 to 6 parts of honeysuckle, 1 to 5 parts of acanthopanax, 10 to 15 parts of green tea, 3 to 7 parts of safflower and 10 to 20 parts of honey. The invention also provides a preparation method of the medicine for preventing and treating pediatric saprodontia. The recipe of the medicine for preventing and treating pediatric saprodontia of the invention is simple, the price is low, the curative effect is obvious, the patient adaptability is strong, and the invention is suitable for being widely popularized in clinics.
Description
Technical field
The present invention relates to field of medicaments, specifically, relate to a kind of medicine of preventing and treating pediatric saprodontia and preparation method thereof.
Background technology
The fluoride preventing decayed tooth has experienced more than 40 year; comprise fluoridation of drinking water, contain fluorine-added milk or fluorine-containing Sal, the part is coated with fluorine multiple measures such as (toothpaste with fluoride, fluoride gel, fluorine-containing collutorys); because fluoride is the caries incidence among the reduction crowd to some extent, and be acknowledged as effectively preventing decayed tooth measure on the our times.The medical circle of oral cavity personage once proposed " the fluoride preventing decayed tooth is one of great achievement in 20th century oral cavity preventive medicine ", but fluoride is still controversial problem in the stomatology field so far to the measurement of human body pros and cons.It seems that at present the use of fluoride preparation has tangible limitation, as dental fluorosis, skeletal fluorosis etc.Therefore, seek the attention that new safe and effective no fluoride preparation more and more is subjected to dental caries prevention and control field scholars.
At present, also use some antibacterial to prevent and treat dental caries.Life-time service broad spectrum antimicrobicide and chemical synthetic drug when removing oral cavity pathogen, have destroyed the ecological balance in oral cavity.Simultaneously, some side effect may appear in the prolonged application antimicrobial drug, as edema, hypertension, bring out and increase the weight of to infect etc.And the antibiotics topical application is easy to produce drug resistance, and long-term topical application also can cause dysbacteriosis and fungal infection.The situation of above-mentioned situation in children's is particularly evident.And if use has the Chinese medicine of antibacterial action, when suppressing pathogenic bacterium, can not destroy the ecological balance in oral cavity." back to nature ", " green remedy " are accepted by more people with its distinctive curative effect and safety simultaneously.In recent years, Chinese medicine is applied to prevent and treats the pharmacology of dental caries and the research of mechanism begins to be subjected to the concern and the attention of Chinese scholars, and obtained progress preferably.Therefore develop a kind of determined curative effect, the convenient and practical medicine of preventing and treating dental caries is becoming inevitable.
Summary of the invention
The purpose of this invention is to provide a kind of medicine of preventing and treating pediatric saprodontia.
The present invention also aims to provide the preparation method of the medicine of described control pediatric saprodontia.
In order to realize method of the present invention, the invention provides a kind of medicine of preventing and treating pediatric saprodontia, it is the medicament of being made according to weight portion by following raw material medicaments: 10～20 parts of 4～8 parts of Radix Scutellariaes, 6～10 parts of Cortex Magnoliae Officinalis, 1～5 part of Fructus Forsythiae, 1～3 part of Herba Artemisiae Scopariae, 1～5 part of Galla Chinensis, 3～6 parts of Flos Loniceraes, 1～5 part of Radix Et Caulis Acanthopanacis Senticosi, 10～15 parts of green tea, 3～7 parts on Flos Carthami and Mel.
Preferably, it is the medicament of being made according to weight portion by following raw material medicaments: 15 parts of 5 parts of Radix Scutellariaes, 8 parts of Cortex Magnoliae Officinalis, 3 parts of Fructus Forsythiaes, 1 part of Herba Artemisiae Scopariae, 3 parts of Galla Chinensiss, 5 parts of Flos Loniceraes, 1 part of Radix Et Caulis Acanthopanacis Senticosi, 10 parts of green tea, 5 parts on Flos Carthami and Mel.
Preferably, the medicine of control pediatric saprodontia of the present invention is buccal tablet or collutory.
The present invention also provides a kind of preparation method of preventing and treating the medicine of pediatric saprodontia, this method comprises the following steps: to take by weighing Radix Scutellariae 50 grams, Cortex Magnoliae Officinalis 80 grams, Fructus Forsythiae 30 grams, Herba Artemisiae Scopariae 10 grams, Galla Chinensis 30 grams, Flos Lonicerae 50 grams, Radix Et Caulis Acanthopanacis Senticosi 10 grams, green tea 100 grams, Flos Carthami 50 grams, Mel 150 grams and water 500 grams, place in the flask of sealing, heating is 2 hours under 70 ℃ water-bath, filter, collect filtrate and promptly get collutory.
The drug prescription of control pediatric saprodontia of the present invention is simple, is common Chinese medicine, low price, and curative effect is clear and definite, and patient adaptability is strong, is suitable for large-scale popularization clinically.
The specific embodiment
Below the invention will be further described for the description by the specific embodiment, but this is not to be limitation of the present invention, those skilled in the art are according to basic thought of the present invention, can make various modifications or improvement, but only otherwise break away from basic thought of the present invention, all within the scope of the present invention.
Embodiment 1
Take by weighing Radix Scutellariae 50 grams, Cortex Magnoliae Officinalis 80 grams, Fructus Forsythiae 30 grams, Herba Artemisiae Scopariae 10 grams, Galla Chinensis 30 grams, Flos Lonicerae 50 grams, Radix Et Caulis Acanthopanacis Senticosi 10 grams, green tea 100 grams, Flos Carthami 50 grams, Mel 150 grams and water 500 grams, place in the flask of sealing, heating is 2 hours under 70 ℃ water-bath, filter, collect filtrate and promptly get collutory.
When using collutory, generally once use 10-20ml.When using collutory of the present invention, can repeatedly gargle after the meal, also can once suck several minutes.Collutory can be told, and also can directly swallow.
Experimental example 1: to the external bacteriostatic activity research of cariogenic bacteria
Streptococcus mutans, actinomyces viscosus are considered to most important cariogenic bacteria, and they form dental plaque by the adhesion to facing, and it is bad to make tooth produce dental caries, therefore suppresses and kill cariogenic bacteria to have important effect to preventing and treating dental caries.In this experimental example, adopt filter paper method classical in this area to carry out bacteriostatic test, wherein:
1. material
1.1 for the examination strain
Actinomyces viscosus (A.viscosus ATCC 15987) and Streptococcus mutans (S.mutans ATCC 25175) are stepped on bio tech ltd available from Shanghai three.
1.2 culture fluid
Nutrient agar and nutrient broth are stepped on bio tech ltd available from Shanghai three.
1.3 test method
Actinomyces viscosus (A.viscosus ATCC 15987) and Streptococcus mutans (S.mutans ATCC 25175) are inoculated on the agar plate nutritional solution plane, evenly gather during inoculation.The aseptic circular filter paper sheet of tweezer immerses the collutory among the embodiment 1, fully behind the dipping, is attached on the agar plate nutritional solution plane of inoculated bacteria.Agar plate placed in 37 ℃ the incubator incubation 24 hours.Measure the diameter of antibacterial ring.Measuring 3 times averages.
1.4 result
The average diameter of the antibacterial ring of actinomyces viscosus (A.viscosus ATCC 15987) is 30.34 mm, the average diameter of the antibacterial ring of Streptococcus mutans (S.mutans ATCC 25175) is 26.47mm, shows that collutory of the present invention has tangible fungistatic effect.
Experimental example 2
1. clinical data
Select 40 examples shallow in the dental caries children as the object of observation, all meet " cariology " (the Yue Songling chief editor. the 1st edition, Chengdu: the Sichuan People's Press, 1983:224-225, diagnosis 280-281) and calibration standard.Be divided into test group and matched group at random.Test group 20 examples wherein, the range of age are 4-7 year, average 5.6 years old, and each 10 example of men and women wherein; Matched group 20 examples, the range of age are 4-7 year, average 5.4 years old, and each 10 example of men and women wherein.
2. observational technique
Test group is used the collutory that makes among the embodiment 1, is all gargling after the meal every day 3 times, each 20ml, and gargle got final product in 30 seconds, and 3 months is 1 course of treatment.Matched group is not used collutory of the present invention.The diet of test group and matched group every day is all identical with the daily life custom.
3. efficacy assessment standard
Adopt the standard of plaque index variation as efficacy assessment standard.Plaque index reduced being assessed as more than 1 effectively, plaque index is remained unchanged or increase be assessed as more than 1 invalid.
(plaque index PLI) is proposed in 1964 by Silness and Loe plaque index, keeps the score and does not keep the score according to the bacterial plaque area coverage according to the thickness of pressure surface bacterial plaque.Be used to estimate the oral hygiene situation and weigh the periodontal disease prevention effect.
With the method inspection of the bonding probes of inspection, inspection is with the probe facing that rows dry, and keeps the score according to the amount and the thickness of bacterial plaque.Plaque index section checks the dental pattern face, also can check several selected teeth.Every tooth is all checked 4 facings, promptly near middle buccal surface, center buccal surface, middle buccal surface far away and lingual surface.Keeping the score of every tooth is that 4 facings are kept the score sum divided by 4, the individual keep the score for every tooth somewhat sum divided by being examined the tooth number.
0=gum edge district does not have bacterial plaque;
The facing in 1=gum edge district has thin bacterial plaque, but inspection is invisible, if can hang up bacterial plaque with the side of probe pinpoint;
2=is in gum edge or the visible moderate bacterial plaque of proximal surface;
It is a large amount of soft enough that in the 3=gingival sulcus or gum edge district is that proximal surface has.
According to before the said method determination test and the plaque index after course of treatment, and change according to plaque index and to obtain following result of the test.
4. result of the test
For test group, there is 15 routine patients' plaque index minimizing 2,5 routine patients' plaque index to reduce 1.For matched group, the plaque index that 16 routine patients' plaque index increases by 1,4 routine patient increases by 2.
Experimental example 3: mouthfeel
Experimenter that please 20 routine test group uses the collutory of embodiment 1.20 patients all represent the good mouthfeel of this collutory, wherein have 8 to be that the patient just swallows under the situation of not doing any suggestion or hint voluntarily.
Experimental example 4: the implication situation in oral cavity
20 routine test group experimenters' implication is comparatively pure and fresh, even the fragrance of tea is arranged.And the implication of the experimenter in the 20 routine matched groups comparatively is difficult to stand, 15 examples even loathsome sensation arranged.
Claims (3)
1. medicine of preventing and treating pediatric saprodontia, it is characterized in that it is the medicament of being made according to weight portion by following raw material medicaments: 10～20 parts of 4～8 parts of Radix Scutellariaes, 6～10 parts of Cortex Magnoliae Officinalis, 1～5 part of Fructus Forsythiae, 1～3 part of Herba Artemisiae Scopariae, 1～5 part of Galla Chinensis, 3～6 parts of Flos Loniceraes, 1～5 part of Radix Et Caulis Acanthopanacis Senticosi, 10～15 parts of green tea, 3～7 parts on Flos Carthami and Mel, described medicament is buccal tablet or collutory.
2. the medicine of control pediatric saprodontia according to claim 1 is characterized in that it is the medicament of being made according to weight portion by following raw material medicaments: 15 parts of 5 parts of Radix Scutellariaes, 8 parts of Cortex Magnoliae Officinalis, 3 parts of Fructus Forsythiaes, 1 part of Herba Artemisiae Scopariae, 3 parts of Galla Chinensiss, 5 parts of Flos Loniceraes, 1 part of Radix Et Caulis Acanthopanacis Senticosi, 10 parts of green tea, 5 parts on Flos Carthami and Mel.
3. preparation method of preventing and treating the medicine of pediatric saprodontia, this method is made up of the following step: take by weighing Radix Scutellariae 50 grams, Cortex Magnoliae Officinalis 80 grams, Fructus Forsythiae 30 grams, Herba Artemisiae Scopariae 10 grams, Galla Chinensis 30 grams, Flos Lonicerae 50 grams, Radix Et Caulis Acanthopanacis Senticosi 10 grams, green tea 100 grams, Flos Carthami 50 grams, Mel 150 grams and water 500 grams, place in the flask of sealing, heating is 2 hours under 70 ℃ water-bath, filter, collect filtrate promptly.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2523619C2 (en) * | 2012-07-02 | 2014-07-20 | Максим Александрович Шевченко | Method of treating dentin caries in permanent teeth in children with incomplete solid tissue mineralisation (versions) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102309663B (en) * | 2011-09-09 | 2013-01-16 | 靳霞 | Medicament for controlling dental caries |
| CN103006513A (en) * | 2012-12-28 | 2013-04-03 | 青岛爱维互动信息技术有限公司 | Chinese herbal medicine mouthwash |
| CN103933454A (en) * | 2014-04-14 | 2014-07-23 | 青岛市市立医院 | Traditional Chinese medicine for treating saprodontia caused by noxious dampness fumigation and preparation method thereof |
| CN104940438A (en) * | 2015-06-16 | 2015-09-30 | 方克贵 | Chinese herbal medicine extract and toothpaste for preventing and treating childhood caries, and application of Chinese herbal medicine extract |
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| CN1179972A (en) * | 1997-09-29 | 1998-04-29 | 杨成玉 | Multifunctional effervescent for cleaning mouth |
| CN101152453A (en) * | 2007-09-20 | 2008-04-02 | 吴月 | Traditional Chinese medicine for treating chronic gingivitis |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1179972A (en) * | 1997-09-29 | 1998-04-29 | 杨成玉 | Multifunctional effervescent for cleaning mouth |
| CN101152453A (en) * | 2007-09-20 | 2008-04-02 | 吴月 | Traditional Chinese medicine for treating chronic gingivitis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2523619C2 (en) * | 2012-07-02 | 2014-07-20 | Максим Александрович Шевченко | Method of treating dentin caries in permanent teeth in children with incomplete solid tissue mineralisation (versions) |
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