CN102188408A - New preparation formulation-paper patch used for preventing diseases of local oral cavity - Google Patents
New preparation formulation-paper patch used for preventing diseases of local oral cavity Download PDFInfo
- Publication number
- CN102188408A CN102188408A CN2010101427788A CN201010142778A CN102188408A CN 102188408 A CN102188408 A CN 102188408A CN 2010101427788 A CN2010101427788 A CN 2010101427788A CN 201010142778 A CN201010142778 A CN 201010142778A CN 102188408 A CN102188408 A CN 102188408A
- Authority
- CN
- China
- Prior art keywords
- paper
- patch
- disease
- oral cavity
- paper patch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Landscapes
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a new preparation formulation using high-quality pure paper (or containing medicament) to be made into paper patch and particular applied to local oral cavity. The paper patch is formed by making a soft paperboard by 36-48 layers of paper with 0.15-0.2cm and cutting into the shape of rectangular strip with 3cm length and 1.2cm width. The paper patch has stronger absorbency, adsorbability, adsorption polymerization (adsorbing and polymerizing antibiosis substances of saliva and gingival crevicular fluid), and hemostatic and protective properties, can getter bacterium, endotoxin and inflammatory cytokines, as well as suppuration smell and bacterial plaque. The new preparation formulation has the functions of eliminating inflammation to stop pain, and stopping bleeding and diminishing swelling, further can protect the mucosa barrier of the oral cavity so as to be free from of invasion of bacterium and endotoxin on the blood and cause cardio-cerebrovascular diseases. Shown by initial trial, the new preparation formulation has tremendous curative effect on toothache. The medicament-containing paper patch can have the effect of being fast in action and high in curative effect, reducing adverse reaction and improving safety. When being used in hypogloeeis, the paper patch provides a novel hypogloeeis paper patch for hypogloeeis administration for treating intracorporal disease, especially cardiovascular disease and respiratory system disease. The product has no adverse effect, is absolutely safe, simple to administrate, no smell and stimulation, and good mouthfeeling, and can be popular with any people. The product is easy to produce, rich in raw materials and low in cost.
Description
Technical field
The present invention relates to make the paper patch, become and specialize in the novel form that oral cavity partial is used for disease preventing and treating with high-quality pure paper product (or containing medicine).
Background technology
Periodontal disease is a kind of modal disease.Because disease all might take place in every tooth.China resident suffers from periodontal disease up to 80%, and middle-aged and elderly people is then up to more than 97%.
Periodontal disease mainly show as red swelling of gingiva, hemorrhage, pyorrhea, gingival atrophy, odontoseisis, finally cause loss of tooth.
Toothache is that the misery that many people once lived through torments, and can not eat, can not sleep, and does not feel better!
Yet periodontal disease does not terminate in the oral cavity to health effects, considerably beyond tooth itself.
Point out: periodontal infection can cause acute subacute infective endocarditis the dentist definite.The Britain scholar once did experiment, and with 76 chronic myocarditis patients that suffer from periodontal disease, after the control periodontal infection, the myocarditis outbreak can reduce by 83%.
Have the expert to find that when the patient to acute myocardial infarction carries out general physical checkup there is oral disease in various degree in patient's great majority, wherein modal is periodontitis and periodontal abscess.The expert of foreign country reaches a conclusion by epidemiological study: gingivitis and other periodontal infections are the independent hazard factors of acute myocardial infarction.
Clinical unit's statistics is arranged,, suffer from the periodontitis person and account for 25% because of coronary heart disease death and the patient who is admitted to hospital; Alveolar bone absorbs to such an extent that the probability of coronary heart disease is higher 1.4 times than periodontal health person, and the probability of suffering from apoplexy is high 2.1 times.The report of U.S. dentistry university research group, the probability that periodontal disease patient gets coronary arteriosclerosis than periodontal health person up to 9 times.Discover that recently porphyromonas gingivalis has the ability of invasion coronary artery endothelial cell, the formation that might excite or aggravate coronary atherosclerosis causes the generation of coronary heart disease.
Owing to suffer from periodontal disease, a large amount of pathogenic bacterium can enter blood circulation from the blood capillary and the lymphatic vessel of impaired periodontal tissue in the oral cavity, the adhesin on pathogenic bacterium surface can combine as specificity with the adhesin receptor of arterial intima and cardiac intima, field planting and breeding cause arterial inflammation and endocarditis.
Causing periodontal disease and invade the pathogenic bacterium of blood circulation, is Gram-negative (G mostly
-) good fortune match bacteroid, porphyromonas gingivalis, blackening general Salmonella, dwell tooth general Salmonella, middle general Salmonella and the nuclear Fusobacterium etc. of bacterium as often being detected in the periodontal focus, these G
-Antibacterial, cell wall contains lipopolysaccharide (endotoxin) invasion blood and internal lesions pathogenic bacterium, the endotoxin that cellular lysate is emitted, and constantly suck the endotoxin that periodontal focus thalline discharged and act on macrophage, neutrophilic granulocyte and endotheliocyte discharge histamine, 5-hydroxy tryptamine, Kallidin I, interleukin (IL
1.6.8) prostaglandin E
2, tumor necrosis factor (TNF) and thromboxane A
2Act on little blood vessel Deng bioactive substance, make its dysfunction, cause microcirculation disturbance, histoorgan blood capillary groundwater increment descends, blood oxygen and blood nutrition supply deficiency.The cellular inflammation factor (interleukin wherein, tumor necrosis factor, prostaglandin and thromboxane) can cause and the change and the thrombocyte degeneration of clotting mechanism destroy vascular endothelial cell and smooth muscle cell, it is atherosis that blood vessel is taken place, and brings out coronary heart disease and apoplexy.Endotoxin also can directly stimulate blood vessel to cause arteriolospasm simultaneously, adds the effect of small thrombosis, can cause the generation of acute myocardial infarction and apoplexy.
If periodontal disease is serious, the periodontal tissue many places wreck, and the pathogenic bacterium and the endotoxin of invading blood flow increase greatly, very likely suddenly send out myocardial infarction and apoplexy fatefulue! So there is the expert seriously to warn: " serious periodontal disease can be taken old man's life by force." be not sensationalism!
In addition, periodontal disease can also be brought out gastropathy, respiratory system disease and acceleration diabetes and be worsened, and also can influence the anemia of pregnant woman, and the probability that premature labor takes place or give birth to the underweight baby exceeds 6 times than normal pregnancies.
As seen, periodontal disease can not be ignored the harm of health.
But, up to now, prevent and treat the pharmacotherapy of periodontal disease, dissatisfied, also unreliable.As oral solid pharmaceutical formulation, earlier through gastrointestinal tract disintegrate, stripping, absorption, again through the internal metabolism operation process, could arrive oral focus, not only consumed medicine but also consuming time, also will be subjected to the restriction of factors such as the sensitivitys of drug level pathogenic bacterium and focus environmental change afterwards, and made curative effect of medication very unreliable.The analgesic drug product of some topical application, because dosage form and improper, medicine is not to spue with saliva, enters gastrointestinal tract and oral mucosa absorption exactly swallow.So often unsatisfactory curative effect often can cause untoward reaction on the contrary.Simultaneously, because the blood of supply root of the tooth does not have other organs of health (each tooth is individual independently organ) abundant, medicine is difficult to arrive inflammation part by blood circulation, plays antiinflammation.And for the pulpitis and the periapical periodontitis that can injure tooth, the toothache that is caused is difficult to stand, and takes medicine don't work, have to go to hospital that tooth is pulled out, or do root canal, the latter is time-consuming, take a lot of work and expensive, but its success rate is not 100%, has only 70--90% at present yet.
Treat periodontal disease at present both at home and abroad, mainly be to strike off dental plaque and tartar with mechanical means, and cooperate cacodontia local application, how to make the sustained-release and controlled release preparation, as tetracycline fiber medicated line with the Tetracyclines medicine, doxycycline gel injection liquid, minocycline ointment injection and minocycline micro-balloon injection inject medicine inside periodontal pockets or insert disease sites, so as to eliminating the pathogenic bacterium of periodontal disease, this method, though obtain better curative effect, its weak point is very obvious also, the one, the therapy complexity must be operated by the doctor in medical institutions, the patient is difficult to accept, thereby the very difficult popularization of this method, and the 2nd, because the antibacterial in the oral cavity is a lot, reach kind more than 300, causing the malignant bacteria of periodontal disease, is not a kind of separately, mostly is two or more pathogenic bacterium and causes, and pathogenic bacterium are to the clinical antibiotic commonly used of periodontal disease, as tetracycline antibiotics, metronidazole, macrolide antibiotic, beta-lactam antibiotic (comprising penicillin and cephalosporins) and fluoroquinolones all can produce drug resistance.This law is caused big difficulty, even might finally bring failure.
Summary of the invention
The invention reside in and propose the novel form that tissues such as A that a kind of utilization meets the pharmaceutical quality standard make it be applicable to oral cavity partial and have the disease preventing and treating performance: the paper patch.
Treatment in-vivo tissue organ disease, generally all to use the oral or injection of Chinese medicine and western medicine, but the disease of treatment body cavity and body surface, except healing with medicine, can also use physiotherapy, promptly be the physical characteristic of utilizing material, make it have function of preventing and treating disease, and will make and be applicable to that focus topical formulations (preparation) directly is used on the focus.
Paper product is a kind of Plant fiber, and is water insoluble, but good hydrophilic is arranged, nontoxic, have no adverse reaction, odorless, tasteless, nonirritant.Chemical property is stable, belongs to a kind of inert material, and has flexibility, attaching property and absorbency, adsorptivity, the poly-property and hemostatic of suction.Because of common very low and quality is also very poor with paper above-mentioned performance, can not use, meet the pharmaceutical quality standard tissues such as A of (, being equivalent to oral medication) because of being is used for the oral cavity so select for use, the above-mentioned performance and the quality of this paper all greatly improve with paper than common, but can't reach requirement.Thereby tissue by the 3-4 layer, the 7-8 layer adds to the 36-48 layer, one deck is close to one deck, makes the soft cardboard of 36-48 layer, and it is cut into is applicable to that the partial rectangle of oral cavity periodontal (long 3CM, wide 1.2CM) strip paper pastes.It is insoluble, not stratified that this paper is attached to oral cavity chance water (saliva), also do not disperse, and more can not become small pieces.Just expand a little,, and utilize viscosity composition in the saliva such as mucin etc., stick on the focus of tooth body layer by layer near, the mutual polymerization of fiber.
Paper pastes the structure of this tens layers paper, and (absorption pathogenic bacterium, endotoxin, the cellular inflammation factor are as prostaglandin E for adsorptivity to have strengthened the absorbency that paper pastes (absorb pus, inflammatory exudate quickens the drain of tip of a root aperture, reduces pulp cavity pressure) greatly
2, interleukin 1 β, tumor necrosis factor and thromboxane A
2And dental plaque, necrocytosis product and opsonigenous substance), inhale poly-property and (inhale the antimicrobial component of poly-saliva and level in gingival sulcus fluid; as: hold the bacterium enzyme; immunoglobulin A .M.G, viscous protein and lactoferrin etc.; strengthen the antibacterial action that paper pastes) it is hemostatic that (saliva can be shortened clotting time; accelerate to strengthen anastalsis) and protectiveness (paper pastes and can carry out seal protection to the periodontal tissue that damages, and control antibacterial and endotoxin enter blood circulation in a large number and cause or increase the weight of cardiovascular and cerebrovascular disease).Thereby making the paper subsides have the anti-inflammatory analgetic effect, the smelly and dental plaque effect of pus is absorbed in the hemostasia and detumescence effect, also has the protective effect of oral mucosa barrier, becomes the novel form that is applicable to the oral cavity partial disease preventing and treating.
The adsorptivity that paper pastes is mentioned in the front, is a considerable physical characteristic.Solid has chemisorbed and physical absorption to the absorption of absorption object, and the former is very firm with the chemical bond combination, is difficult to take off absorption, is irreversible adsorption, as shown in the formula:
A
Gu+ B
Thing→ A
GuB
Thing(1)
Because of paper pastes is a kind of inert material, chemisorbed can not take place, but paper pastes the Plant fiber who is made up of a lot of glucose molecule, and there are numerous hydroxyl polarity genes on the surface of fiber, thereby paper pastes many materials, physical bond effect (adsorption) takes place as microorganism, endotoxin and the cellular inflammation factor etc., because consumes energy seldom, or energy consumption hardly, and is very insecure, taking off absorption easily, is reversible adsorption.As shown in the formula:
This is a kind of dynamic equilibrium, adsorbs with the quantity of taking off absorption to equate, although be both physical absorption, and the branch that also has absorption affinity to vary in size.Absorption affinity is bigger, when reaching balance, the quantity that is not adsorbed in the system is just less, absorption affinity is less, the quantity that is not adsorbed during balance is just many, weak curative effect even invalid will appear like this, how to remedy? top adsorption equation (2) is told us, remove the antibacterial that is not adsorbed, endotoxin, the cellular inflammation factor etc., has only a way, be exactly after the paper subsides are used, the short time (ineffective in the 5min-10min) promptly renews subsides, exchanges cards containing all personal details and become sworn brothers continuously several times, can be absorptions fully such as pathogenic bacterium, as the self awareness toothache that acute inflammation causes, due to illness the breeding of kitchen range pathogenic bacterium is vigorous, and quantity is a lot, pasting 1-2 time with paper can not very fast anti-inflammatory analgetic, must use new subsides instead every 5-10min continuously, could remove pathogenic bacterium at short notice, and reach the purpose of quick anti-inflammatory analgetic.
This way, we are commonly called as it and are " method mops floor ", and the ground for very dirty mops floor 1-2 time, drags untotally certainly, does not reach clean purpose, if mop floor after 1-2 time, mop is not just rinsed well and is dragged, and drags unclean so forever.Because of the soil (as dust etc.) that adsorbs on the mop can take off absorption, must whenever drag once, drag again after rinsing well, could thoroughly clean up like this.This is with frequently using new subsides instead, and reason is the same.
But to the shake-up toothache due to the chronic inflammatory disease because focal organism is few, can by early, middle and late after meal each with subsides, just can deal with problems, because cross several hrs with pasting the back, antimicrobial component resists pathogenic bacterium jointly in poly-saliva of paper subsides suction and the level in gingival sulcus fluid, cures chronic inflammatory disease.
The periodontal disease focus, be not resemble the floor smooth, antibacterial is hidden nowhere, the most ticklish clinically pathogenic bacterium that will ensconce at last in the periodontal pocket, the dark more difficult more removing of periodontal pocket, paper pastes and has stronger imbibition and absorption property fortunately, can absorb pus and the transudate that contains pathogenic bacterium in the periodontal pocket, passed through 2-3 days, 5-6 days or longer time usefulness subsides can be removed the complete sucking-off of the antibacterial in the periodontal pocket eventually.
Cause periodontal infection and cause the reason of dental caries, it mainly is dental plaque, there is the pathogenic bacterium dental plaque can cause odontitis disease, the cariogenic bacteria dental plaque is arranged, can cause the formation of dental caries, dental plaque, saliva was completely spread tooth surface and teeth space before this, and also field planting and breeding above pathogenic bacterium and cariogenic bacteria (Streptococcus mutans) drop on becomes bacterial plaque.In fact bacterial plaque is the viscous protein of saliva and the Mycoderma that antibacterial is formed, so as long as sooner or later correctly brush teeth routinely every day, bacterial plaque can not form, the paper patch can prevent the shaping of bacterial plaque, also can eliminate existing bacterial plaque, certainly, bacterial plaque has the old and new's branch, we are like this with it classification, if the independent subsides of paper subsides remove the old bacterial plaque of not falling of crying with the new bacterial plaque of crying that it can be removed, old bacterial plaque is that the Mycoderma accumulation forms, not only greatly but also more firm, but it is not the tartar of calcification, but the very strong entity of hydrophilic.Stick paper and paste, inhale the saliva in poly-oral cavity, bacterial plaque is soaked, through certain hour, bacterial plaque will be become flexible in imbibition, collapses so that collapse, just as the landslide, at this time, old bacterial plaque is easy to be eliminated when brushing teeth, and pastes even tartar sticks paper, at least can not allow the free bacterium of tartar encroach on tooth, time has been grown the variation along with oral environment, and tartar will fade away, and can never strengthen gradually and increase the weight of.
Liquid in the oral cavity (saliva and level in gingival sulcus fluid) contains antimicrobial components such as active leukocyte, lysozyme, Immunoglobulin IgA, IgG, IgM, mucin and lactoferrin, especially active leukocyte and immunoglobulin, can engulf and kill pathogenic bacterium, lysozyme can destroy the cell wall of antibacterial, makes bacteria inactivation.Paper pastes can make full use of these disease-resistant factors from body, inhales poly-these antimicrobial components, has formed strong antibiotic collaborative battle line jointly, can act on the pathogenic bacterium of inflammation focus, quickens inflammation and disappears, and also can prevent the pathogenic bacterium invasion focus of outside.
Paper pastes and can stop blooding, and saliva can be shortened clotting time, and paper pastes can inhale thromboplastic active component in the poly-saliva, has strengthened the hemostasis usefulness that paper pastes.Therefore, periodontal blooding or oral cavity tissue suffer damage and hemorrhage, paste not only hemostasis rapidly with paper, but also can blood capillary be sealed owing to blood coagulation, prevent that antibacterial from entering blood flow.
Saliva is contained buffer system, has the ability of regulating acid-base value, and paper pastes inhales poly-a large amount of salivas, utilizes its buffer system, can in and the acidic materials that produced of Streptococcus mutans carbohydrate metabolism, prevent the generation of dental caries.
Lifting practical numerical example is below verified.
Have a toothache after the one routine supper, pain is more felt bad just before going to bed, and right side lower jaw tooth (1-8C) is pain all, and this is that pulpitis causes the radiating symptom of pain.Owing to can not determine it is that tooth is had an attack of one's old illness, can't locate, have to there be the place of pain just to paste, once shared 3 paste, and about 10min exchanges cards containing all personal details and become sworn brothers once, exchanges cards containing all personal details and become sworn brothers twice altogether, gets final product complete pain relieving, goes to sleep peacefully.Because dental pulp blood vessel transudate increases, and tip of a root aperture can not in time be gone out the transudate drain, pulp cavity pressure strengthens, and pressuring nerve tip and causing has an intense pain.Paper pastes then can utilize its absorbent, accelerates the drain of tip of a root aperture, makes pulp cavity blood pressure lowering gradually, and pain alleviates gradually to complete obiteration.But the absorbent that paper pastes is subjected to time restriction, should renew subsides after sticking 10min, need exchange cards containing all personal details and become sworn brothers to making teleneuron pressurized not fully, reaches complete aim of alleviating pain.
Another example realizes that p.prand the terminal alveolus of right maxillary tooth (1-8A) and 8C is all indistinctly sore, though be not severe pain unbearably, also feel uncomfortable.And the right side head has intermittent some pain, and the place of just posting pain is immediately pasted with 4 altogether and pasted, remove before the supper and paste, have only the atomic pain sensation, do not paste with new, but sleep to midnight, former state again pain come together, and have slightly and increase the weight of, paste 4 according to the former choice specimen of calligraphy with paper immediately and paste, behind about 10min, sleeping heavily again, removed in second day to paste and check, have only the alveolus on upper right third molar (8A) and next door thereof to also have the atomic pain sensation, by the morning, noon and afternoon with one be attached to terminal molar around, the 3rd day pain sensation and inflammation are eliminated fully.This example is suspected to be the terminal molar chronic pulpitis of upper right third molar (8A) upper jaw.
1 routine lower-left frist premolar (4D) gingival swelling and pain, so tooth do not have medical history, so be diagnosed as gingivitis, is attached on the inflammation gingiva with paper, is less than 10min, gets final product pain relieving.The morning, 9 morbidities were were respectively exchanged cards containing all personal details and become sworn brothers once respectively after lunch and the supper, and stayed and be attached to getting up early in second day and remove to paste check the inflammation complete obiteration.One ice lolly that makes an exception out is not eaten up, bottom right frist premolar (4C), pain get up, promptly paste after very reluctantly the going home in a hurry with paper, less than 10 minutes, pain was promptly ended, after the pain relieving not reuse paste.
Upper right side incisor (2A) swells and ache after the one routine supper, gently presses or nibbles before the right nostril and close, be i.e. pain, be diagnosed as periapical periodontitis, the once sick mistake of this tooth, a bit loosening, but still the certain ability of chewing of tool, promptly paste, still feel pain behind the 10min, use the new subsides 10min pain sensation instead and alleviate with paper, the pain sensation greatly alleviates after renewing subsides 10min again, use new subsides just before going to bed instead, paste back analgesis in a moment, very fast sleeping.Getting up early in second day removes to paste and checks, inflammation disappears, but finds upper jaw facial swelling, and jawbone has tenderness, illustrates that inflammation shifts.At this moment, by early, middle and late each subsides after meal every day, logotype two days, facial swelling disappears, the ability of chewing before recovery is sick.
Another routine upper right third molar (8A) periapical periodontitis, this tooth was once suffered from chronic pulpitis, and tongue is touched a tender spot around the tip of a root, and is difficult to open and chews, and Yi Zhangzui is pain more, and promptly be attached to and suffer from around the root of the tooth with paper, shared two subsides, logotype two days, the disappearance of swelling and ache is magnified and has been chewed also not bitterly.
Pathogenic bacteria enters human bloodstream from body cavity (oral cavity, nasal cavity, gastrointestinal tract, vagina and urethra) and body surface (whole body epidermis and eye mask), the highest with the probability that enters from the oral cavity, quantity is maximum, because the kind of oral cavity bacterium is a lot, reach kind more than 300, antibacterial has 2,000 hundred million approximately in the common people oral cavity, and quantity is very big, is the hat of each body cavity of whole body and body surface.The oral cavity has suitable temperature and acid-base value, and competent nutrient is arranged, and makes antibacterial ramp breeding, and periodontal infection all very likely takes place every tooth in the oral cavity, is not easy again to cure very soon.Periodontal tissue is in damaged condition for a long time, allows antibacterial enter blood circulation for a long time in a large number, and visible oral mucosa barrier is to prevent that antibacterial from entering the of paramount importance outpost of the tax office of human body, also is that antibacterial enters the main passage of blood flow.
Periodontal disease is that periodontal tissue is inflamed and is destroyed, and this means that the oral mucosa barrier is destroyed, for oral cavity pathogen invasion blood flow has opened wide the gate, has opened passage.Owing to also there is not a kind of pharmaceutical preparation that is applicable to oral cavity partial so far, periodontal disease can not in time effectively be prevented and treated, do not know to have how many middle-aged and elderly people because of suffering from periodontal disease, make tooth lose masticatory function too early and come off or pull out, even caused the cardiovascular and cerebrovascular disease of threat to life safety.
Paper pastes and can directly be attached in the ruined periodontal tissue; under the synergism of saliva of buccal cavity and the relevant effective ingredient of level in gingival sulcus fluid; not only can prevent and treat periodontal disease, hemostasia and detumescence, analgesic antiphlogistic, remove pus is smelly, prolong tooth life-span and masticatory function; what is more important can play the close and protect effect; block the gate and the passage of bacterial invasion, prevent that prolific pathogenic bacterium in inflammation focus and oral cavity and the endotoxin of emitting thereof from entering blood circulation in a large number and bring out or increase the weight of cardiovascular and cerebrovascular disease.
My 05-07 violates arrhythmia, uncomfortable in chest, cardiopalmus annual summer, feels out of it, the helpless examination in hospital that goes, and the myocarditis of saying so has been opened anti-arrhythmic, sees that description toxicity is big, does not have medication.Pasted with paper since 07 year winter and to paste, every gingival hemorrhage, red swelling of gingiva, odontoseisis, gingival atrophy, periodontal abscess, gingivitis, brush teeth hemorrhagely, all use paper to paste, because of this has been cured, another kind of odontopathy takes place again.Be not interrupted with the paper subsides till now from 07 year.But arrhythmia does not take place in 08 year to 09 year summer, chest distress and palpitation symptoms no longer yet.This has verified that also the front mentioned Britain scholar's experimental result, and the control periodontal infection can make the number of times of chronic myocarditis outbreak reduce by 83%.
The present invention compared with prior art has following advantage.
1, paper pastes therapy, unlike the oral drugs therapy, does not have operation process and gastrointestinal absorption in the body, does not also arrive so much restraining factors after the focus, directly is attached to the focus surface, and curative effect is reliable rapidly.
2, this product is not antibacterials, does not exist sensitivity with insensitive, and Resistant strain and non-Resistant strain no matter be antibacterial or mycete, completely absorb absorption with it and remove, and are absolute wide spectrum bacteria removers.
3, many medicines antibiotic particularly, body or pathogenic bacterium produce drug resistance to it, but paper is pasted then without any drug resistance, and how long the subsides time that don't work has, and it is constant that it prevents and treats curative effect.
4, the breeding of inflammation focus pathogenic bacterium is vigorous more, and the degerming in the unit interval of paper patch is many more, and its degerming speed is directly proportional with the quantity of focal organism, belongs to one-level degerming speed, and available following formula is expressed:
U=KC V=degerming speed K=speed constant C=bacterial concentration
Medication does not have this effect, and the phase antisense bacterial is many more, and the effect of antibacterials is poor more.
5, the paper multiple favourable disease-resistant factors such as antibiotic factor, antihemorrhagic factor, factor of adhesion and adjusting pH value factor of pasting the saliva can utilize the oral cavity and level in gingival sulcus fluid are strengthened the paper local curative effect of pasting usefulness of body that loses money in a business, and other oral local administrations but are difficult to utilize even destroy these active factors.
6, the most outstanding curative effect of this product, be to end toothache to make us pleasantly surprised especially, no matter be self awareness (acute inflammation) toothache, still shake-up property toothache (chronic inflammatory disease) can both pain relieving, there is not invalid case, what pulpitis caused has an intense pain, generally go to hospital tooth to be pulled out or does root canal when can't stand, but just paste and to stop pain with paper, go to sleep peacefully, but because paper pastes the focus of deadend tissue of tooth, elimination causes the cold and hot sour-sweet of toothache, factors such as allergy and pressure make the people not have the pain sensation and pain relieving to transmitting the stimulation of pain nerve tip.
7, an example is violated toothache, begin to eat somedon, lip is numb, itch all over, use the periodontal recovering capsule instead, invalid, after change coupling acetylspiramycin (3), diclofenac sodium (1) and prednisone (2) into, 2 times/day, logotype 3 days, toothache has been prevented, and has emitted but have a stomachache, and this is the gastric ulcer that back two kinds of medicines and periodontal recovering capsule are caused.The modern subsides with paper treated, and not only curative effect is reliable rapidly, and does not have any untoward reaction, is perfectly safe.
8, this product usage is simple, ordinary people's one usefulness will, can use voluntarily, need not medical personnel and instruct.
9, this product does not have taboo, the allergic constitution person, and the anemia of pregnant woman, the hepatic and kidney function obstacle person, the many patients of the old and the weak, the nursing women all can use.
10, this product odorless, tasteless, also nonirritant, good mouthfeel, no matter men and women, old and young, Chinese or foreigner, anyone be happy to employing.
11, this product processing technology is simple, and raw material sources are abundant, and cost is very low, and product is cheap, promotes the use of easily.
12, the paper subsides are the good carriers of oral local administration, can make the paper patch that contains medicine, as the subsides of antibacterials paper, the subsides of Cortex Ilicis Rotundae (active component of clean silver-colored toothpaste) paper, the subsides of YUNNAN BAIYAO paper and other Chinese medicine and western medicine paper subsides etc., can give full play to the therapeutical effect of these medicines, be expected all to receive that effect is fast, curative effect is high and reduce or eliminate the effect of untoward reaction.
13, be used for the paper patch of oral cavity partial, be not limited to prevent and treat oral disease.For example: treat angina pectoris and prevent and treat dysmenorrhoea with the nifedipine sublingual lozenge, it can be changed into nifedipine paper pastes, the Sublingual is pasted and is used, because of the nifedipine gastrointestinal absorption poor, big through the liver metabolism loss, bioavailability is too low, and oral mucosa absorbs without liver, directly enters blood circulation, the bioavailability height, rapid-action, faster than sublingual lozenge, because nifedipine has become micron, millimicron even molecularity high degree of dispersion are in paper pastes, after pasting, medicine promptly is absorbed, and tablet still is in the disintegrate stage.
Its similar medicine such as lercanidipine (lercanidipine) and azelnidipine (azelnidipine) all are that intestinal and liver metabolic rate are very high, and its metabolite is non-activity all, can consider to make the paper patch.There is following several situation can consider that sublingual administration makes the paper patch.1, gastrointestinal side effect is big.2, gastrointestinal absorption is poor.3, the destructive metabolism rate height of liver (intestinal).4, be used for the treatment of cardiovascular system, respiratory system and cerebral nerve disease.
As Ketek (Telithramycin) suffer from abdominal pain, suffer from diarrhoea, feel sick, gastrointestinal reaction such as vomiting is bigger.The liver destructive metabolism is mainly treated the respiratory system infection disease up to 70%, as pneumonia, chronic bronchitis, sinusitis, pharyngitis etc.
If Ketek is made the paper patch, absorb faster, faster arrival infection site, play antibacterial and anti-inflammation functions rapidly, can avoid the destructive metabolism of gastrointestinal side effect and liver, reduce dosage, reduce untoward reaction, also have a bit special the prompting, Ketek has anaphylaxis (dyspnea, urticaria, mouthful, eye, face swelling) whether medicine paper patch can check the patient irritated to this medicine in the subsides time spent, finds to have above-mentioned reaction when pasting with Ketek paper as subsides, remove immediately to paste and gargle, the removing Ketek retains the oral cavity, if other medications are withdrawal to retrieve as behind injection or the oral medication anaphylaxis being arranged.Certainly, sublingual administration will solve the picric acid flavor problem that common people can't stand.
Significance of the present invention.
1, the present invention has developed the new purposes of paper product, enlarges and improve the intension and the value of the paper culture of our ancestors invention.
2, the present invention can draw a series ofly from innovative product, and this current just country advocates needs of scientific development.
3, the present invention has started the physical characteristic of utilizing paper product, has successfully realized the purpose of preventing and curing diseases in the oral cavity.Can utilize paper product or unclassified stores to prevent and treat the disease of body surface and body cavity?
4, the oral cavity is first defence line of health, and the paper patch is a kind of modern weapon of safeguarding that oral health provides, and will bring into play its important function.Owing to there is not usage simple, everybody the certain therapy of curative effect that can use of common people, gingivitis fails to cure fully, allow inflammation become periodontal disease to the deep development, gingivitis is first the position of causing periodontal disease, is the first inflammation disease of the easiest healing with the paper patch, if the paper patch is released, because product is cheap, every household can be bought standby.In case find that tooth is inflamed or has a toothache, common people will promptly paste with paper, and inflammation or toothache are cured rapidly, really bring into play the effect of its protection health.
5, Sublingual paper patch, the medicine to numerous treatment in-vivo tissue organ diseases provides new route of administration method and novel form, and these curative effect of medication are not fully exerted, and reduces untoward reaction, improves safety.
6, each medicine almost must be made and be applicable to clinical preparation (system type) at first through the PROCESS FOR TREATMENT of pharmaceutics.Medicine just can play and bring into play therapeutical effect.Therefore we can say that pharmaceutics is the soul of pharmacy, preparation (dosage form) then is the life of pharmaceutics.The innovation of dosage form, a kind of novel form is successfully released, and injects great vitality not only for the development of pharmaceutics, and has brought distinguished progress to clinical treatment.
Description of drawings
Fig. 1 is a paper patch schematic appearance
1 is that length 2 is height (thickness that is equivalent to 36-48 layer tissue) for width 3
Fig. 2 is that sketch map is used in paper patch oral cavity
Paper patch (1) is horizontal to be attached on the gum buccal groove (2) and the surface between the corona (3) of cacodontia, covers 3-4 tooth approximately, by the clamping power of oral cavity and tooth and the adhesive attraction of saliva, paper patch (1) is sticked on the tooth body.
The specific embodiment
Embodiment 1, and paper patch quality standard is tentatively drafted
It is exactly to make with tissues such as A merely that paper pastes, the industry quality standard such as the table 1 of tissues such as A:
Table 1
Be used for the oral cavity because paper pastes, be equivalent to oral medication, should be stricter to prescription, quality standard should be higher.So some projects in must his-and-hers watches 1 will be revised, and increase some inspection items.
Microbial check, wherein escherichia coli should detect, and increase to check mycete (every gram is no more than 100) and check the demodicid mite (must not detect) that lives.Moisture in the table 1 must not change into 4%, and laterally water absorption changes into and is not less than 30mm/100s.
Also to increase following inspection item: acid-base value---PH should be 6-7.5; Solute in the water---leaving over residue must not surpass 0.2%; Chloride---with the contrast liquor ratio must not denseer (0.03%); Residue on ignition---leave over residue and must not cross 0.2%; Heavy metal---must not cross 10/1000000ths; Arsenic salt---must not cross 0.0002%.
In addition, also need increase character and discriminating two tops
More than increase inspection item and inspection method, can reach other relevant inspection methods down referring to two 978 pages " microcrystalline Cellulose " items of Chinese Pharmacopoeia version in 2000.
Producer's mass production paper pastes, and at first according to the quality standard of above paper patch, carries out PROCESS FOR TREATMENT trial-production with tissues such as A, reach requirement up to every quality index, formulate the technological operation rules, do the small lot test manufacture earlier, after the examination and test of products is qualified, just go into operation in a large number.Resemble to do and make soft cardboard the tissue, it is cut into the wide 1.2cm of the long 3cm of (see figure 1) (1) (2), 36-48 layer thickness 0.15-0.2cm (3) paper pastes.
But must be noted that following some:
1, paper pastes and must meet the quality standard that is equivalent to oral drugs set forth above.
2, produce the workshop that paper pastes, must meet the quality of production management regulation (GMP) of oral solid pharmaceutical formulation.
3, paper pastes the requirement of moisture strictly, and the product that dispatches from the factory should be controlled moisture 2-3%, and it is then better to be lower than this value, because the curative effect of this and paper subsides is closely related.
The space that semi-finished product and finished product expose when 4, producing, must control relative humidity must not be greater than 35%.
5, produce the paper subsides and use paper, except that adding a small amount of bleach, must not add and use any additives, comprise spice, need not embossing.
6, finished paper is pasted best singlely seal with aluminum is thin.
7, periodontal can be made the rectangle strip with medicine paper patch, but the number of plies can suitably reduce, and not necessarily makes the rectangle strip as just pasting as Sublingual paper, and shapes such as other are square, circle all can, the number of plies can greatly reduce, and decides according to the character and the Sublingual situation of medicine.
Before the paper subsides, necessarily gargle earlier, wash one's hands, dry the finger that operation paper pastes, the most handy 75% alcohol disinfecting with the napkin handle.(see figure 2) paper pastes (1) and is attached between the gum buccal groove (2) of cacodontia and the corona (3)
On the surface (1), cover 3-4 tooth approximately.If control toothache, every 5min--10min exchanges cards containing all personal details and become sworn brothers once, if severe pain unbearably, exchange cards containing all personal details and become sworn brothers after can pasting back 5min, no matter which pastes (also comprising first the subsides), pastes pain relieving in the 10min of back, then need not promptly to exchange cards containing all personal details and become sworn brothers, stay to be attached to after meal or early to exchange cards containing all personal details and become sworn brothers after the meal in second day, and respectively exchange cards containing all personal details and become sworn brothers once respectively after the meal, with till anti-inflammatory analgetic fully by every day three.
Gingival hemorrhage, dense, the no conscious sympton that overflows can be attached to paper earlier and doubt on the gingiva of suffering from tooth, take out after 1 hour and observe, and it is also non-yellowing smelly not have bloodstain as white, belongs to normal.Post bloodstain or displaing yellow and frowziness as paper, the prompting cacodontia finds, and every day is early, middle and late, and each one pastes after meal, uses continuously to paper and pastes no bloodstain, also non-yellowing smelly till.As find that tooth has loosening or chews to be occluding with and ache, and should promptly paste with paper, daily three paste, and one paste after meal.
Pasting the obstruction cavity with paper also should brush teeth earlier, gargle, soil in the hole is removed totally, and as sterilizing with finger manipulation, dental caries is sore, except that stopping up cavity, also paste with paper in the tooth surface and paste, paper pastes when stopping up cavity, can use and take the photograph son and toothpick for a short time, for a short time taking the photograph son puts spitball in the hole into, with toothpick (cutting off most advanced and sophisticated sharp part),, change the paper plug every day once the spitball jam-pack.
The long-pending easily food bits of hiding of teeth space, tartar and long bacterial plaque and cause periodontal disease and dental caries are pasted the seam of getting stuck between the teeth in right amount with paper, can prevent that food gets stuck between the teeth, and also can prevent the growth of periodontal infection and cariogenic bacteria.
Claims (5)
1. one kind is applicable to the novel form of preventing and treating oral disease, it is characterized in that using Plant fiber and/or cellulose to make raw material, makes the Plant fiber and/or the cellulose patch that are applicable to oral cavity partial.
2. according to described Plant fiber of claim (1) and/or cellulose patch, it is characterized in that the service property (quality) standard is higher than the paper product of napkin technical specification such as A, make the paper patch that the different numbers of plies or different quite deal difformity and size are applicable to oral focus.
3. according to the described paper patch of claim (2), it is characterized in that the service property (quality) standard is higher than the paper product and the medicine of tissue technical specification such as A, makes the medicine paper patch that difformity and size are applicable to periodontal and Sublingual.
4. according to described Plant fiber of claim (1) and/or cellulose patch, it is characterized in that using Plant fiber and/or cellulose powder, make and have paper and paste Plant fiber and/or the cellulose patch that physical characteristic is applicable to the oral cavity partial disease preventing and treating.
5. according to described Plant fiber of claim (4) and/or cellulose patch, it is characterized in that using Plant fiber and/or cellulose powder dosing thing, make the iatric fiber mourning card agent that difformity and size are applicable to periodontal and Sublingual.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101427788A CN102188408A (en) | 2010-03-09 | 2010-03-09 | New preparation formulation-paper patch used for preventing diseases of local oral cavity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101427788A CN102188408A (en) | 2010-03-09 | 2010-03-09 | New preparation formulation-paper patch used for preventing diseases of local oral cavity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102188408A true CN102188408A (en) | 2011-09-21 |
Family
ID=44597848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010101427788A Pending CN102188408A (en) | 2010-03-09 | 2010-03-09 | New preparation formulation-paper patch used for preventing diseases of local oral cavity |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102188408A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102499904A (en) * | 2011-10-17 | 2012-06-20 | 徐柔云 | Lamellate medicinal bag for treating tooth diseases |
| CN103315825A (en) * | 2012-03-18 | 2013-09-25 | 杨柳青 | Gingival crevicular fluid absorption rod |
| CN103405401A (en) * | 2013-08-08 | 2013-11-27 | 余秀民 | Specific paper patch used for treating periodontosis |
| CN104027325A (en) * | 2014-03-18 | 2014-09-10 | 余秀民 | Paper patch with special effects for treating bacterial inflammatory toothache |
-
2010
- 2010-03-09 CN CN2010101427788A patent/CN102188408A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102499904A (en) * | 2011-10-17 | 2012-06-20 | 徐柔云 | Lamellate medicinal bag for treating tooth diseases |
| CN103315825A (en) * | 2012-03-18 | 2013-09-25 | 杨柳青 | Gingival crevicular fluid absorption rod |
| CN103405401A (en) * | 2013-08-08 | 2013-11-27 | 余秀民 | Specific paper patch used for treating periodontosis |
| CN104027325A (en) * | 2014-03-18 | 2014-09-10 | 余秀民 | Paper patch with special effects for treating bacterial inflammatory toothache |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100420432C (en) | Gargle and its preparing process | |
| CN104244912B (en) | Have and alleviate oral cavity pain and kill oral cavity bacterium and the natural antibacterial dentifrice composition of stable neural effect | |
| Nagilla et al. | Comparative evaluation of antiplaque efficacy of coconut oil pulling and a placebo, among dental college students: A randomized controlled trial | |
| CN101744939A (en) | Chinese medicinal herb compound and preparation method with health care effect for preventing mouth disease | |
| CN108670889A (en) | A kind of toothpaste and preparation method thereof of anti-treating dental ulcer | |
| CN102858308A (en) | Toothpaste composition for tooth health | |
| Bratthall et al. | Oral and craniofacial diseases and disorders | |
| CN102188408A (en) | New preparation formulation-paper patch used for preventing diseases of local oral cavity | |
| CN103462877B (en) | A kind of dentifrice composition containing active composition inclusion | |
| Rahmatova | Modern prevention and effective treatment of dental caries in children | |
| CN103550274B (en) | A kind of medicine preparation for oral cavity | |
| Prakash et al. | Effect of punica granatum extract gel on gingival crevicular fluid levels of interleukin-1β, interleukin-8 and CCL28 levels: randomised controlled clinical trial | |
| CN101254235B (en) | Method of preparing extract for curing periodontal diseases | |
| Whyman et al. | Dens in dente associated with infective endocarditis | |
| CN101559046A (en) | Therapeutic action of micromolecule sugar alcohol composite on nasal disease | |
| CN106474137A (en) | One kind is containing chlorophyllous film for treating oral ulcer and preparation method thereof | |
| Bogdanov | Short history of honey in medicine | |
| RU2580615C1 (en) | Method of treating periodontitis | |
| CN103933274A (en) | Traditional Chinese medicine preparation for treating periodontitis | |
| CN100387249C (en) | Traditional Chinese medicine formulation for treating ulcer | |
| SOMASUNDARAM | Aloe vera as an herbal remedy in dentistry. | |
| Schimmel et al. | Palliative care and complications of cancer therapy | |
| CN1289144C (en) | Medicine for treating radioactive membrana mucosa damage, repeative aphtha and paradentitis | |
| Tobor et al. | The impact of caries on human health-a review of knowledge | |
| Meurman | Preventive oral health care for elderly people |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20110921 |