CN102961728B - Medicament for preventing and treating children saprodontia - Google Patents
Medicament for preventing and treating children saprodontia Download PDFInfo
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- CN102961728B CN102961728B CN201210534910.9A CN201210534910A CN102961728B CN 102961728 B CN102961728 B CN 102961728B CN 201210534910 A CN201210534910 A CN 201210534910A CN 102961728 B CN102961728 B CN 102961728B
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Abstract
The invention relates to a medicament for preventing and treating children saprodontia, and the medicament is prepared from the following raw materials in parts by weight: 4-8 parts of dried ginger, 6-10 parts of herba rabdosiae, 1-5 parts of loofah sponge, 1-3 parts of hypericum japonicum, 1-5 parts of sarel spleenwort herb, 3-6 parts of Chinese tamarisk twig, 1-5 parts of acanthopanax, 10-15 parts of radices sileris, 3-7 parts of the root of Chinese pulsatilla, 10-20 parts of dragonhead herb, 3-6 parts of radix stemonae, 10-15 parts of cortex cinnamomi, 4-8 parts of siberian fritillary bulb, 1-5 parts of amur adonis herb, 1-3 parts of radix ophiopogonis and 3-7 parts of cocklebur fruit. The medicament for preventing and treating children saprodontia has the advantages of simple prescription, low price, clear treatment effect and strong adaptability to patients, and is suitable for broad promotion in clinical.
Description
Technical field
The present invention relates to oral cavity, particularly field, department of pediatrics oral cavity, specifically, relate to a kind of medicament of preventing and treating pediatric saprodontia.
Background technology
Children's is owing to processing growth and development stage, and tooth is changed more frequent, and the protection coating of dental surface immaturity also, and children's enjoys a lot to eat sweet food in addition, and therefore, the ratio of suffering from dental caries in children's is very high.Developing a kind of determined curative effect, the convenient and practical medicine of preventing and treating dental caries is becoming inevitable.
Summary of the invention
The object of this invention is to provide a kind of medicament of preventing and treating pediatric saprodontia.
In order to realize method of the present invention, the invention provides a kind of medicament of preventing and treating pediatric saprodontia, it is the medicament of being made according to weight portion by following raw material medicaments: 3～7 parts of 4～8 parts of Rhizoma Zingiberiss, 6～10 parts of Rabdosia rubescens, 1～5 part of Retinervus Luffae Fructus, 1～3 part of Herba Hyperici Japonici, 1～5 part of Herba Pteridis creticae, 3～6 parts of Cacumen Tamariciss, 1～5 part of Radix Et Caulis Acanthopanacis Senticosi, 10～15 parts of Radix Saposhnikoviaes, 3～7 parts of the Radix Pulsatillaes, 10～20 parts of Herba Dracocephali Integrifoliis, 3～6 parts of the Radixs Stemonae, 10～15 parts of Cortex Cinnamomis, 4～8 parts of Bulbus Fritillariae Pallidifloraes, 1～5 part of Amur Adonis Herb, 1～3 part of Radix Ophiopogonis and Fructus Xanthii.
Preferably, the medicament of control pediatric saprodontia of the present invention is the medicament of being made according to weight portion by following raw material medicaments: 5 parts of 5 parts of Rhizoma Zingiberiss, 8 parts of Rabdosia rubescens, 3 parts of Retinervus Luffae Fructuss, 2 parts of Herba Hyperici Japonici, 4 parts of Herba Pteridis creticae, 5 parts of Cacumen Tamariciss, 2 parts of Radix Et Caulis Acanthopanacis Senticosis, 11 parts of Radix Saposhnikoviaes, 6 parts of the Radix Pulsatillaes, 15 parts of Herba Dracocephali Integrifoliis, 5 parts of the Radixs Stemonae, 12 parts of Cortex Cinnamomis, 7 parts of Bulbus Fritillariae Pallidifloraes, 3 parts of Amur Adonis Herbs, 2 parts of Radix Ophiopogonis and Fructus Xanthii.
Preferably, the medicament of control pediatric saprodontia of the present invention is tablet, buccal tablet, instant or collutory.
The medicament prescription of control pediatric saprodontia of the present invention is simple, is common Chinese medicine, low price, and curative effect is clear and definite, and patient adaptability is strong, is suitable for large-scale popularization clinically.
The specific embodiment
Below the invention will be further described for the description by the specific embodiment, but this is not limitation of the present invention, those skilled in the art are according to basic thought of the present invention, can make various modifications or improvement, but only otherwise depart from basic thought of the present invention, all within the scope of the present invention.
Embodiment 1
Take 5 grams of 5 grams of Rhizoma Zingiberiss, 8 grams of Rabdosia rubescens, 3 grams of Retinervus Luffae Fructuss, 2 grams of Herba Hyperici Japonici, 4 grams of Herba Pteridis creticae, 5 grams of Cacumen Tamariciss, 2 grams of Radix Et Caulis Acanthopanacis Senticosis, 11 grams of Radix Saposhnikoviaes, 6 grams of the Radix Pulsatillaes, 15 grams of Herba Dracocephali Integrifoliis, 5 grams of the Radixs Stemonae, 12 grams of Cortex Cinnamomis, 7 grams of Bulbus Fritillariae Pallidifloraes, 3 grams of Amur Adonis Herbs, 2 grams of Radix Ophiopogonis and Fructus Xanthii, be placed in the flask of sealing, add 1000 milliliters, water, under the water-bath of 70 ℃, heat 2 hours, be cooled to room temperature.Then filter, collect filtrate and be collutory.
Experimental example 1: the In Vitro Bacteriostatic research to cariogenic bacteria
Streptococcus mutans, actinomyces viscosus are considered to most important cariogenic bacteria, and they form dental plaque by the adhesion to facing, make tooth produce dental caries bad, therefore suppress and kill cariogenic bacteria to have important effect to preventing and treating dental caries.In this experimental example, adopt filter paper method classical in this area to carry out bacteriostatic test, wherein:
1. material
1.1 for examination strain
Actinomyces viscosus (A.viscosus ATCC 15987) and Streptococcus mutans (S.mutansATCC 25175) are purchased from San Ta bio tech ltd, Shanghai.
1.2 culture fluid
Nutrient agar and nutrient broth, purchased from San Ta bio tech ltd, Shanghai.
1.3 test method
Actinomyces viscosus (A.viscosus ATCC 15987) and Streptococcus mutans (S.mutans ATCC 25175) are inoculated in agar plate nutritional solution plane, during inoculation, evenly gather.The aseptic circular filter paper sheet of tweezer immerses the collutory in embodiment 1, fully after dipping, is attached in the agar plate nutritional solution plane of inoculated bacteria.Agar plate is placed in the incubator of 37 ℃ to incubation 24 hours.Measure the diameter of antibacterial ring.Measure and average for 3 times.
1.4 result
The average diameter of the antibacterial ring of actinomyces viscosus (A.viscosus ATCC 15987) is 30.34mm, the average diameter of the antibacterial ring of Streptococcus mutans (S.mutans ATCC 25175) is 26.47mm, shows that collutory of the present invention has obvious fungistatic effect.
Experimental example 2
1. clinical data
Select the shallow middle dental caries child of 40 example as the object of observation, all meet < < cariology > > (Yue Songling chief editor. the 1st edition, Chengdu: the Sichuan People's Press, 1983:224-225,280-281) diagnosis and calibration standard.Be divided at random test group and matched group.Test group 20 examples wherein, the range of age is 3-7 year, average 5.2 years old, each 10 examples of men and women wherein; Matched group 20 examples, the range of age is 3-7 year, average 4.9 years old, each 10 examples of men and women wherein.
2. observational technique
Test group is used the collutory making in embodiment 1, every day 3 times, is all gargling after the meal, and each 20ml, gargles 30 seconds, within 3 months, is 1 course for the treatment of.Matched group is gargled with pure water according to the mode identical with test group.The diet of test group and matched group every day is all identical with daily life custom.
3. efficacy assessment standard
Adopt plaque index to change the standard as efficacy assessment standard.Plaque index is reduced to 1 and is assessed as above effectively, plaque index is remained unchanged or increase by 1 be assessed as above invalid.
Plaque index (plaque index, PLI) is proposed in 1964 by Silness and Loe, according to the thickness of pressure surface bacterial plaque, scores and according to bacterial plaque area coverage, does not score.Be used for evaluating oral hygiene situation and weigh periodontal disease prevention effect.
With the method inspection of the bonding probes of inspection, inspection is with the probe facing that rows dry, and according to the amount of bacterial plaque and thickness, scores.Plaque index section checks dental pattern face, also can check several selected teeth.Every tooth all checks 4 facings, i.e. nearly middle buccal surface, center buccal surface, middle buccal surface far away and lingual surface.Scoring of every tooth is that 4 facings are scored sum divided by 4, and individual scores as every tooth a few minutes sum is divided by being examined tooth number.
0=Yin Yuan district is without bacterial plaque;
The facing in 1=Yin Yuan district has thin bacterial plaque, but inspection is invisible, if can hang up bacterial plaque with the side of probe pinpoint;
2=is in gum edge or the visible moderate bacterial plaque of proximal surface;
It is a large amount of soft enough that 3=gingival sulcus Nei Huoyinyuan district is that proximal surface has.
According to the plaque index before said method determination test and after the course for the treatment of, and change and obtain result of the test below according to plaque index.
4. result of the test
For test group, there is 16 routine patients' plaque index minimizing 2,4 routine patients' plaque index to reduce 1.For matched group, the plaque index that 18 routine patients' plaque index increases by 1,2 routine patient increases by 2.
Claims (2)
1. prevent and treat a medicament for pediatric saprodontia, it is characterized in that it is the medicament of being made according to weight portion by following raw material medicaments: 3～7 parts of 4～8 parts of Rhizoma Zingiberiss, 6～10 parts of Rabdosia rubescens, 1～5 part of Retinervus Luffae Fructus, 1～3 part of Herba Hyperici Japonici, 1～5 part of Herba Pteridis creticae, 3～6 parts of Cacumen Tamariciss, 1～5 part of Radix Et Caulis Acanthopanacis Senticosi, 10～15 parts of Radix Saposhnikoviaes, 3～7 parts of the Radix Pulsatillaes, 10～20 parts of Herba Dracocephali Integrifoliis, 3～6 parts of the Radixs Stemonae, 10～15 parts of Cortex Cinnamomis, 4～8 parts of Bulbus Fritillariae Pallidifloraes, 1～5 part of Amur Adonis Herb, 1～3 part of Radix Ophiopogonis and Fructus Xanthii.
2. the medicament of control pediatric saprodontia according to claim 1, is characterized in that it is the medicament of being made according to weight portion by following raw material medicaments: 5 parts of 5 parts of Rhizoma Zingiberiss, 8 parts of Rabdosia rubescens, 3 parts of Retinervus Luffae Fructuss, 2 parts of Herba Hyperici Japonici, 4 parts of Herba Pteridis creticae, 5 parts of Cacumen Tamariciss, 2 parts of Radix Et Caulis Acanthopanacis Senticosis, 11 parts of Radix Saposhnikoviaes, 6 parts of the Radix Pulsatillaes, 15 parts of Herba Dracocephali Integrifoliis, 5 parts of the Radixs Stemonae, 12 parts of Cortex Cinnamomis, 7 parts of Bulbus Fritillariae Pallidifloraes, 3 parts of Amur Adonis Herbs, 2 parts of Radix Ophiopogonis and Fructus Xanthii.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410054865.6A CN103751760B (en) | 2012-12-06 | 2012-12-06 | A kind of preparation method of preventing and treating the medicament of pediatric saprodontia |
| CN201210534910.9A CN102961728B (en) | 2012-12-06 | 2012-12-06 | Medicament for preventing and treating children saprodontia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201210534910.9A CN102961728B (en) | 2012-12-06 | 2012-12-06 | Medicament for preventing and treating children saprodontia |
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| CN201410054865.6A Division CN103751760B (en) | 2012-12-06 | 2012-12-06 | A kind of preparation method of preventing and treating the medicament of pediatric saprodontia |
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| CN102961728A CN102961728A (en) | 2013-03-13 |
| CN102961728B true CN102961728B (en) | 2014-02-19 |
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| CN201410054865.6A Active CN103751760B (en) | 2012-12-06 | 2012-12-06 | A kind of preparation method of preventing and treating the medicament of pediatric saprodontia |
| CN201210534910.9A Expired - Fee Related CN102961728B (en) | 2012-12-06 | 2012-12-06 | Medicament for preventing and treating children saprodontia |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1229656A (en) * | 1998-03-24 | 1999-09-29 | 郭秀琴 | Chinese medicine for treating toothache |
| CN1448081A (en) * | 2002-12-18 | 2003-10-15 | 李永胜 | Pear, peach and apricot honey sugar slab for prevention and cure of cough and asthma |
| CN1698779A (en) * | 2005-05-25 | 2005-11-23 | 邵建国 | Toothache relieving oral cavity spray and its preparation method |
| CN102266505A (en) * | 2011-07-26 | 2011-12-07 | 天津市顶硕科贸有限公司 | Compound Chinese medicinal oral mucosa repair liquid |
| CN102688347A (en) * | 2012-06-11 | 2012-09-26 | 张松波 | Traditional Chinese medicine preparation for treating oral inflammation and preparation method thereof |
-
2012
- 2012-12-06 CN CN201410054865.6A patent/CN103751760B/en active Active
- 2012-12-06 CN CN201210534910.9A patent/CN102961728B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1229656A (en) * | 1998-03-24 | 1999-09-29 | 郭秀琴 | Chinese medicine for treating toothache |
| CN1448081A (en) * | 2002-12-18 | 2003-10-15 | 李永胜 | Pear, peach and apricot honey sugar slab for prevention and cure of cough and asthma |
| CN1698779A (en) * | 2005-05-25 | 2005-11-23 | 邵建国 | Toothache relieving oral cavity spray and its preparation method |
| CN102266505A (en) * | 2011-07-26 | 2011-12-07 | 天津市顶硕科贸有限公司 | Compound Chinese medicinal oral mucosa repair liquid |
| CN102688347A (en) * | 2012-06-11 | 2012-09-26 | 张松波 | Traditional Chinese medicine preparation for treating oral inflammation and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102961728A (en) | 2013-03-13 |
| CN103751760B (en) | 2015-09-23 |
| CN103751760A (en) | 2014-04-30 |
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