CN1169516C - Oral cleaning detergent component and tooth-paste, tooth powder component - Google Patents
Oral cleaning detergent component and tooth-paste, tooth powder component Download PDFInfo
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- CN1169516C CN1169516C CNB981117139A CN98111713A CN1169516C CN 1169516 C CN1169516 C CN 1169516C CN B981117139 A CNB981117139 A CN B981117139A CN 98111713 A CN98111713 A CN 98111713A CN 1169516 C CN1169516 C CN 1169516C
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Abstract
The present invention relates to an oral cavity-rinsing agent composition and a dentifrice composition which have adsorbed physiologically active substances, e.g. perilla extract, propolis, or the like, with anti-inflammatory action, anti-irritability action and antibacterial action, and/or polyose clastic enzyme and proteindegrading enzyme, e.g. dextranase and mutant enzyme. The oral cavity-rinsing agent composition has hydroxyapatite fine grains, having 0.01-10 um average particle diameter, as a principal solid constituent. The invention is useful for beautifully whitening teeth and the prophylaxis of footorexare and also having multifunctions which are to continuously prevent caries, and the destruction and inflammation of periodontium (e.g. periodontal disease) for a long period.
Description
The present invention relates to the invention of the oral cleaning detergent component of a kind of toothpaste, tooth powder component etc.Particularly relate to a kind of tooth-whitening effectively, prevention halitosis, long-term periodontal tissue such as caries prevention and periodontitis constantly damages and the oral cleaning detergent component of the toothpaste of inflammation, tooth powder component etc.
Have up to now much to prevent that periodontal disease from being that toothpaste, the tooth powder component of purpose sold on market.These toothpaste, tooth powder component are to be grinding-material with solid particles such as calcium hydrogen phosphate two hydrated salts, calcium hydrogen phosphate anhydrous salt, tricalcium phosphates, be aided with various medicaments again, used alone or in combination as selecting medicament from Gluconate chlohexidine, iodate polyvinylpyrrolidone, thujaplicin, glycyrrhizin, allantoic acid, tranamic acid, thymol, episilon amino caproic acid, β-enoxolone, Cera Flava etc. with bactericidal action and anti-inflammatory.
Compositions such as contained calcium hydrogen phosphate two hydrated salts, calcium hydrogen phosphate anhydrous salt, tricalcium phosphate in last note toothpaste, the tooth powder component are as good grinding-material, though demonstrate the toothbrushing effect of effective removal tartar.But, but do not have the initiatively tooth whitening effect of functions of whitening teeth.In addition, have going up of bactericidal action and anti-inflammatory effect and remember various medicaments, though the various antibacterials that the boil on the nape opposite the mouth intracavity exists when brushing teeth demonstrate effective bactericidal effect.But this bactericidal action is very of short duration, exist brush teeth the back water when gargling medicament from the oral cavity, flow out the problem that bactericidal effect can not be continued.
On the other hand, because the constituent of hydroxyapatite and tooth enamel belongs to same chemical constituent.So, wish in recent years to obtain the repairing of tooth and toothpaste, the tooth powder component of whitening effect goes on the market one after another with hydroxyapatite, improved the effect of repairing and tooth-whitening.But, be that the toothpaste, tooth powder component of main solid constituent is to caries prevention and periodontal disease, though effect such as the tooth of removal dirt is arranged with hydroxyapatite.But it is highly effective that this preventive effect can't be said so.
Main purpose of the present invention is to provide a kind of oral cleaning detergent component and toothpaste, tooth powder component, make its effectively tooth-whitening, prevention halitosis, and can be that long-term periodontal tissue such as caries prevention and periodontitis constantly damages and the multiple function of inflammation.
Oral cleaning detergent component of the present invention and toothpaste, tooth powder component, it is adsorbing biological active substanceies such as anti-inflammatory material, antianaphylaxis material, antibiotic property material and/or polysaccharide catabolic enzyme, protease at particle surface, former granule mean diameter is main solid constituent at the hydroxyapatite particles of 0.01～10 μ m (hope is 0.1～5 μ m) scope.Biological active substanceies such as these anti-inflammatory materials, antianaphylaxis material, antibiotic property material preferably are the animals and plants biological active substances of representative with Radix Puerariae extract, Radix Glycyrrhizae extract, Aloe extract, Folium perillae extract, Folium Camelliae sinensis extract, Cera Flava, lactoferrin matter.In addition, the polysaccharide catabolic enzyme has the microorganism glucanase, and protease has microbial mutation body enzyme (or Mutanolysin).
The embodiment of oral cleaning detergent component of the present invention is paste, aqueous or pulverous toothpaste, tooth powder component.But also can be various aqueous oral cleaning detergent components with title such as electuary, collutory, the water of brushing teeth listing in the oral cavity.The hydroxyapatite particles that is adsorbing biological active substanceies such as anti-inflammatory material, antianaphylaxis material, antibiotic property material and/or polysaccharide catabolic enzyme, protease at particle surface of the present invention, it is when paste toothpaste constituent, and common weight ratio by 3%～15% is fitted in the constituent; When being the oral cleaning detergent component of water preparation, common weight ratio by 0.1%～1% is fitted in the constituent.
Make the medicament of material absorption medicine, at affected part medicament is emitted the treatment that medicament Xu's place system (Drug Delivery System:DDS) of effectively treating is used in cancer and inflammation widely slowly again.But on prevention and treatment dental caries and periodontitis, also be not carried out use.In addition, enzyme is fixed on makes it continue to play a role on the carrier, this is carried out use on the industrial utilization of enzyme.But also be not carried out use for prevention and treatment dental caries and periodontitis at dental field.
The inventor considers because hydroxyapatite and tooth enamel belong to same chemical constituent, so whether, can utilize the interface (neck portion) of its recess that is adsorbed onto tooth (position of dental caries) and tooth and tooth meat and the function on the tartar, the hydroxyapatite that is adsorbing biological active substanceies such as anti-inflammatory material, antianaphylaxis material, antibiotic property material and/or polysaccharide catabolic enzyme, protease in advance is adsorbed onto on the interface (neck portion) and tartar of the recess of tooth (position of dental caries) and tooth and tooth meat.Under this state, if can continue to bring into play anti-inflammatory effect, anti-allergic effects, antibacterial action, polysaccharide decomposition, proteolysis, wouldn't be the propagation that can continue to suppress the antibacterial in dental caries, periodontal pathogenic bacteria and the tooth dirt effectively so.
Based on last note idea, the inventor is research with keen determination several times, found that as absorption on the hydroxyapatite particles of the micro-crystallization state of carrier and have anti-inflammatory effect, anti-allergic effects, antibacterial action, the polysaccharide decomposition, behind the material of proteolysis, utilize hydroxyapatite particles to dentine, the intensive absorbability that tooth meat and tartar are had, can make and have anti-inflammatory effect, anti-allergic effects, antibacterial action, the polysaccharide decomposition, the material of proteolysis is trapped in affected part for a long time, has anti-inflammatory effect thereby can make, anti-allergic effects, antibacterial action, the polysaccharide decomposition, the material of proteolysis continues to play a role, can be effective, continue to suppress dental caries chronically, the propagation of antibacterial in periodontal pathogenic bacteria and the tooth dirt, and then finished the present invention.
Be that example is described in detail with representational toothpaste, tooth powder component in the oral cleaning detergent component of the present invention below.
Toothpaste of the present invention, the employed hydroxyapatite particles of tooth powder component, its former granule mean diameter is as long as (hope is 0.1～5 μ m at 0.01～10 μ m; Be preferably 0.1～3 μ m) scope in, so no matter be that synthesizing hydroxylapatite or natural hydroxyapatite can use.So-called synthesizing hydroxylapatite is meant with wet type or the synthetic hydroxyapatite of dry type; So-called its representational example of natural hydroxyapatite has natural minerals hydroxyapatite and bone hydroxyapatite.Also can the two mixes use with synthesizing hydroxylapatite and natural hydroxyapatite.
Toothpaste of the present invention, the employed hydroxyapatite particles of tooth powder component, carried out on its surface having anti-inflammatory effect and (or) anti-allergic effects and (or) adsorption treatment of the biological active substances of antibacterial action, and (or) carried out the polysaccharide catabolic enzyme and (or) adsorption treatment of protease.For be used for hydroxyapatite particles adsorption treatment of the present invention have anti-inflammatory effect and (or) anti-allergic effects and (or) biological active substances of antibacterial action and (or) the polysaccharide catabolic enzyme and (or) protease, though there is no particular limitation, preferably use Chinese medicine ingredients or animals and plants material or microbiological materials little at the oral cavity internal stimulus and that adsorptivity is good.As have anti-inflammatory effect and (or) anti-allergic effects and (or) Chinese medicine ingredients or the animals and plants examples of substances of antibacterial action, Radix Puerariae extract, Radix Glycyrrhizae extract, Folium perillae extract, Folium Camelliae sinensis extract, Aloe extract, Cera Flava, lactoferrin matter are arranged; As microbial polysaccharide class catabolic enzyme example glucanase is arranged in addition; The example of microprotein catabolic enzyme has mutant enzyme.
Radix Puerariae extract, Radix Glycyrrhizae extract also have anti-inflammatory, the antibiotic property composition that is widely known by the people as Chinese medicine.Folium perillae extract is to extract from the leaf of Folium Perillae section plant, and its Detoxication, refrigeration function are just understood by people from ancient times.Recently, its anti-allergic effects and antitumor action are also gazed at by people.Cera Flava is pollen and the secretions (resin etc.) of plant and the mixing thing of bee secretion (Cera Flava etc.) that Apis is gathered.Folium Camelliae sinensis extract contains the catechin inductor.Lactoferrin matter is the antibiotic property material that obtains from milk.Glucanase is a microbial enzyme, is the enzyme of glucosan of main component that is decomposed to form the tooth dirt of dental caries hotbed.Mutant enzyme is the protease that destroys caries bacteria Streptococcus mutance cell membrane.
The present invention is by with hydroxyapatite particles, put into and dissolved or disperseed to resemble in the liquid of biological active substances the note, these materials are adsorbed on the surface of hydroxyapatite particles, then this hydroxyapatite particles is modulated into fraction or dry thing, again it is mixed with other toothpaste, tooth powder component composition, and then obtain required toothpaste, tooth powder component.
When on the hydroxyapatite particles surface of biological active substances, carrying out adsorption treatment, dissolved or disperseed the mixing ratio (weight ratio) of the liquid and the hydroxyapatite particles of biological active substances, numerical range at 1: 150～10: 1 preferably mixes at 1: 30～1: 2 numerical range.Adsorption treatment also can be carried out when modulation toothpaste, tooth powder component.The hydroapatite particles surface, biological active substances is preferably adsorbed with the weight of 0.01～0.1% scope with 0.001～1% weight (hydroapatite particles is a weight basis).
Oral cavity of the present invention detersive constituent in the scope of not damaging effect of the present invention, can contain the adding ingredient that is contained in toothpaste, tooth powder component and other oral cavity cleaning constituents arbitrarily.For example, xylitol (キ シ リ ト-Le), trehalose can be combined with, glucanase, mutant enzyme and vitamin C, citric acid etc. can be combined with as enzyme as sweeting agent.
[embodiment]
(embodiment 1)
According to usual way, the toothpaste, the tooth powder component (unit: weight %) that form shown in time note the 1st table have been made.
The 1st table
| HAp | Brushite | Plant and carry | Xylitol | Trehalose | Glucanase | Dimension C | Moving carrying | Host | |
| Test portion 1 | 40 | 60 | |||||||
| Test portion 2 | 40 | 2 | 58 | ||||||
| Test portion 3 | 5 | 35 | 60 | ||||||
| Test portion 4 | 5 | 35 | 2 | 58 | |||||
| Test portion 5 | 5 | 35 | 2 | 2 | 2 | 54 | |||
| Test portion 6 | 5 | 35 | 2 | 2 | 2 | 1 | 53 | ||
| Test portion 7 | 5 | 35 | 2 | 2 | 2 | 1 | 0.5 | 52.5 | |
| Test portion 8 | 5 | 35 | 2 | 1 | 57 | ||||
| Test portion 9 | 5 | 35 | 2 | 2 | 2 | 2 | 0.5 | 1 | 51.5 |
| Test portion 10 | 15 | 25 | 2 | 58 | |||||
| Test portion 11 | 15 | 25 | 2 | 2 | 2 | 1 | 0.5 | 1 | 51.5 |
| Test portion 12 | 15 | 25 | 5 | 50 | |||||
| Test portion 13 | 15 | 25 | 5 | 2 | 2 | 2 | 1 | 48 |
First each mark of table is expressed as follows the meaning:
HAp: hydroxyapatite particles (former granule mean diameter: 0.05～0.2 μ m)
Brushite (Brushite): the mineral name of calcium hydrogen phosphate two hydrated salts
Plant and carry: the extract of plant Folium Perillae
Dimension C: vitamin C
Moving carrying: animal extracts Cera Flava
Host: the abbreviation of toothpaste, dentifrice host comprises the wetting agents such as glycerol of frequent use, interfacial agents such as N-sarcosyl, bonding agent such as carboxycellulose methyl ether sodium, and general spice and water.
(embodiment 2)
As the example of plant extract, in the 3ml of market sale Folium perillae extract, add 100mg hydroxyapatite particles (former granule mean diameter: 0.05～0.2 μ m), then under 37 ℃ temperature, vibrated 15 minutes.After centrifugalize, filtration again, dried the hydroxyapatite particles that is adsorbed with Folium perillae extract.And reduce method with heating weight the amount of the Folium perillae extract of absorption is measured.
By measuring, confirmed the Folium perillae extract adsorbance of hydroxyapatite particles Unit Weight, to exceed more than 3 times than calcium hydrogen phosphate two hydrated salts (the main grinding agent that ordinary toothpaste dentifrice is contained).The hydroxyapatite particles that is adsorbed with Folium perillae extract is cleaned with distilled water, then measure the amount of the Folium perillae extract that washes out from hydroxyapatite particles, learn whenever to wash once to wash out 5% of adsorbance that it is obviously much smaller that this primary sorption amount of whenever washing when using calcium hydrogen phosphate two hydrated salts flows out 25% numerical value.Hence one can see that, and the Folium perillae extract amount of hydroxyapatite particles absorption is big, and the amount that washes out simultaneously is few.Therefore in the occasion of using hydroxyapatite particles, just can be for a long time, continue, obtain effectively the effect of the slow release of Folium perillae extract.
(embodiment 3)
40 adult men and women are divided into 5 groups, each group is used the toothpaste of making among the embodiment 1 respectively, dentifrice test portion 1 (do not have and add), test portion 2 (combination of calcium hydrogen phosphate two hydrated salts and plant extract), test portion 3 (hydroxyapatite particles is only arranged), test portion 4 (hydroxyapatite particles has adsorbed Folium perillae extract) and test portion 7 are (after hydroxyapatite particles carried out the Folium perillae extract adsorption treatment, cooperate xylitol again, trehalose, glucanase, vitamin C), sooner or later each brush once carried out the dyeing of tooth dirt and the Periodentel Index (P.I.) of expression periodontal tissue's inflammation and damage was observed after 2 months every day.
Observed result is as shown in the table, uses the test portion (test portion 4 and test portion 7) that hydroxyapatite particles has adsorbed plant extract can reduce the P.I. value effectively as can be known.
The 2nd table
| P.I. value when beginning to test | P.I. value when experiment finishes | |
| Test portion 1 | 0.55±0.11 | 0.53±0.13 |
| Test portion 2 | 0.58±0.15 | 0.49±0.18 |
| Test portion 3 | 0.53±0.15 | 0.35±0.20 |
| Test portion 4 | 0.61±0.20 | 0.18±0.12 |
| Test portion 7 | 0.48±0.17 | 0.09±0.10 |
(embodiment 4)
During the dye test of last note tooth dirt, 2 weeks after on-test, use the beam split chromascope that fibrescope is housed, measured the whiteness of each test portion subject's maxillary front tooth.Its result is shown in the 3rd table.
The 3rd table
| Whiteness when beginning to test | Whiteness after the experiment | |
| Test portion 1 | 42.0±2.0 | 42.0±0.8 |
| Test portion 2 | 36.0±1.0 | 38.0±1.5 |
| Test portion 3 | 47.0±3.5 | 53.0±2.3 |
| Test portion 4 | 39.0±1.2 | 45.0±3.0 |
| Test portion 7 | 41.0±0.8 | 47.0±1.1 |
Whiteness when beginning to test with each test portion is 100% to compare, and the whiteness test portion 1 after the experiment is 0%; Test portion 2 increases to 5%; The test portion 3,4,7 that has added hydroxyapatite particles has then increased by 13%, 15%, 15% whiteness respectively.
(embodiment 5)
According to usual way, the toothpaste, the tooth powder component (unit: weight %) that form shown in time note the 4th table have been made.(animals and plants extract such as Cera Flava, Aloe extract, Radix Puerariae extract, lactoferrin matter and microorganism glucanase are after having done the hydroxyapatite particles adsorption treatment in advance, are coupled in toothpaste, the tooth powder component.)
The 4th table
| HAp | Brushite | Cera Flava | Aloe | Radix Puerariae | Lactoferrin | Glucanase | Host | |
| Test portion 14 | 5 | 35 | 3 | 57 | ||||
| Test portion 15 | 5 | 35 | 3 | 57 | ||||
| Test portion 16 | 5 | 35 | 3 | 57 | ||||
| Test portion 17 | 5 | 35 | 3 | 57 | ||||
| Test portion 18 | 5 | 35 | 1 | 59 | ||||
| Test portion 19 | 15 | 25 | 5 | 55 | ||||
| Test portion 20 | 15 | 25 | 5 | 55 | ||||
| Test portion 21 | 15 | 25 | 5 | 55 | ||||
| Test portion 22 | 15 | 25 | 5 | 55 | ||||
| Test portion 23 | 15 | 25 | 2 | 58 |
The 4th each mark of table is expressed as follows the meaning:
HAp: hydroxyapatite particles (former granule mean diameter: 0.05～0.2 μ m)
Brushite (Brushite): the mineral name of calcium hydrogen phosphate two hydrated salts
Cera Flava: animal extracts Cera Flava (market sale product)
Aloe: the aloetic extract of plant (market sale product)
Radix Puerariae: the extract of Chinese medicine Radix Puerariae (market sale product)
Lactoferrin: Bovine Lactoferrin matter (market sale product)
Glucanase: microorganism glucanase (market sale product)
Host: comprise the wetting agents such as glycerol that often use in toothpaste, the dentifrice, interfacial agents such as N-sarcosyl, bonding agent such as carboxycellulose methyl ether sodium, and general spice and water.
(embodiment 6)
As the example of animal extracts, in the 3ml of market sale Cera Flava, add 100mg hydroxyapatite particles (former granule mean diameter: 0.05～0.2 μ m), then under 37 ℃ temperature, vibrated 15 minutes.After centrifugalize, filtration again, dried and be adsorbed with mellisic hydroxyapatite particles.
And reduce method with heating weight the mellisic amount of absorption is measured.
By measuring, confirmed the Cera Flava adsorbance of hydroxyapatite particles Unit Weight, to exceed more than 5 times than calcium hydrogen phosphate two hydrated salts (the main grinding agent that ordinary toothpaste dentifrice is contained).To be adsorbed with mellisic hydroxyapatite particles cleans with distilled water, then measure the mellisic amount that washes out from hydroxyapatite particles, learn whenever to wash once to wash out 10% of adsorbance that it is obviously much smaller that this primary sorption amount of whenever washing when using calcium hydrogen phosphate two hydrated salts flows out 30% numerical value.Hence one can see that, and the Cera Flava amount of hydroxyapatite particles absorption is big, and the amount that washes out simultaneously is few.Therefore in the occasion of using hydroxyapatite particles, just can be for a long time, continue, obtain effectively the effect of the slow release of Cera Flava
(embodiment 7)
15 adult men and women are divided into 5 groups, each group is used the toothpaste of making among the embodiment 5 respectively, dentifrice test portion 14 (hydroxyapatite particles and beeswax combination), test portion 15 (hydroxyapatite particles and Aloe extract combination), test portion 16 (hydroxyapatite particles and Radix Puerariae extract combination), test portion 17 (hydroxyapatite particles and the combination of lactoferrin matter) and test portion 18 (hydroxyapatite particles and glucanase combination), sooner or later each brush once carried out the dyeing of tooth dirt and the Periodentel Index (P.I.) of expression periodontal tissue's inflammation and damage was observed after 2 months every day.
Observed result is as shown in the table, uses hydroxyapatite particles to adsorb the test portion of animals and plants extract and polysaccharide catabolic enzyme as can be known, can reduce the P.I. value effectively.
The 5th table
| P.I. value when beginning to test | P.I. value after the experiment | |
| Test portion 14 | 0.48±0.09 | 0.14±0.08 |
| Test portion 15 | 0.58±0.10 | 0.16±0.08 |
| Test portion 16 | 0.63±0.11 | 0.16±0.08 |
| Test portion 17 | 0.52±0.12 | 0.15±0.10 |
| Test portion 18 | 0.55±0.08 | 0.20±0.09 |
Oral cleaning detergent component of the present invention is a carrier with the hydroxyapatite particles of micro-crystallization structure, makes it adsorb biological active substances and/or glucanase and such polysaccharide catabolic enzyme, the proteases of mutant enzyme such as Folium perillae extract with anti-inflammatory effect, anti-allergic effects, antibacterial action and Cera Flava.And the energy of adsorption of using that hydroxyapatite particles has to the brute force of dentine, tooth meat and tooth dirt, make have anti-inflammatory effect, the biological active substances of anti-allergic effects, antibacterial action and/or polysaccharide catabolic enzyme, protease can be detained at affected part for a long time.And then the lasting effect of bringing into play anti-inflammatory substance, antiallergic material, antibiotic substance, polysaccharide catabolic enzyme, protease in the oral cavity.Therefore can suppress the breeding of the antibacterial in dental caries pathogenic bacteria, periodontal pathogenic bacteria and the tooth dirt effectively, for a long time, constantly.
Claims (6)
1. oral cleaning detergent component, comprising polysaccharide catabolic enzyme adsorbed on hydroxyapatite particles and this microparticle surfaces, it is characterized in that, the original mean diameter of hydroxyapatite particles is 0.01～10um in the described constituent, also is adsorbed with the biological active substances and/or the protease of anti-inflammatory effect and/or anti-allergic effects and/or antibacterial action on this microparticle surfaces.
2. the described oral cleaning detergent component of claim 1, it is characterized in that the biological active substances of described anti-inflammatory effect and/or anti-allergic effects and/or antibacterial action is selected from Radix Puerariae extract, Radix Glycyrrhizae extract, Folium perillae extract, Folium Camelliae sinensis extract, Aloe extract, Cera Flava, lactoferrin matter; Described polysaccharide catabolic enzyme is selected from glucanase; Described protease is selected from mutant enzyme.
3. claim 1 or 2 described constituents is characterized in that, the original mean diameter of described hydroxyapatite particles is 0.05～5um.
4, claim 1 or 2 described constituents is characterized in that, the percentage by weight of described constituent in the toothpaste constituent is 3～15%.
5. claim 1 or 2 described constituents is characterized in that, the percentage by weight of described constituent in the oral cleaning detergent component of water preparation is 0.1～1%.
6, the tooth powder component that contains any one described constituent in the claim 1 to 2.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2363375/1998 | 1998-08-07 | ||
| JP23633798A JP4199333B2 (en) | 1998-08-07 | 1998-08-07 | Dentifrice composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1244386A CN1244386A (en) | 2000-02-16 |
| CN1169516C true CN1169516C (en) | 2004-10-06 |
Family
ID=16999321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB981117139A Expired - Fee Related CN1169516C (en) | 1998-08-07 | 1998-12-23 | Oral cleaning detergent component and tooth-paste, tooth powder component |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP4199333B2 (en) |
| CN (1) | CN1169516C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104271143A (en) * | 2012-04-02 | 2015-01-07 | 克洛克斯科技公司 | Preventing or treating periodontal disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20010111819A (en) * | 2000-06-13 | 2001-12-20 | 서진호 | The oral cleaning medicine containing the propolis |
| JP4865961B2 (en) * | 2001-07-13 | 2012-02-01 | 剛之 児玉 | Oral composition |
| JP2004026701A (en) * | 2002-06-25 | 2004-01-29 | Hideko Uechi | Composition for oral cavity |
| JP4712323B2 (en) * | 2004-07-08 | 2011-06-29 | 湧永製薬株式会社 | Oral composition |
| US20100266989A1 (en) | 2006-11-09 | 2010-10-21 | Klox Technologies Inc. | Teeth whitening compositions and methods |
| US8658219B2 (en) | 2008-11-07 | 2014-02-25 | Klox Technologies Inc. | Oxidatitive photoactivated skin rejeuvenation composition comprising hyaluronic acid, glucosamine, or allantoin |
| US8685466B2 (en) | 2009-07-17 | 2014-04-01 | Klox Technologies Inc. | Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease |
| US20120251981A1 (en) * | 2011-03-22 | 2012-10-04 | Klox Technologies Inc. | Device and method for administering teeth whitening and antimicrobial compositions |
| US20120244491A1 (en) * | 2011-03-22 | 2012-09-27 | Remigio Piergallini | Device and method for teeth brightening |
| US11116841B2 (en) | 2012-04-20 | 2021-09-14 | Klox Technologies Inc. | Biophotonic compositions, kits and methods |
| US20130281913A1 (en) | 2012-04-20 | 2013-10-24 | Klox Technologies Inc. | Biophotonic compositions and methods for providing biophotonic treatment |
| RU2494725C1 (en) * | 2012-08-20 | 2013-10-10 | Общество С Ограниченной Ответственностью "Сплат-Косметика" (Ооо "Сплат-Косметика") | Mineral enzymatic complex for enamel strengthening and whitening, oral hygiene composition and tooth paste |
| MX351267B (en) | 2012-09-14 | 2017-10-06 | Valeant Pharmaceuticals Int Inc | Compositions and methods for teeth whitening. |
| US20140276354A1 (en) | 2013-03-14 | 2014-09-18 | Klox Technologies Inc. | Biophotonic materials and uses thereof |
| JP6351929B2 (en) * | 2013-03-21 | 2018-07-04 | 株式会社ロッテ | Oral composition for reducing hypersensitivity |
| JP2015083562A (en) * | 2013-09-18 | 2015-04-30 | 第一三共ヘルスケア株式会社 | Composition for oral cavity comprising drug carrier with specific average particle diameter |
| CN104706549A (en) * | 2013-12-11 | 2015-06-17 | 江南大学 | Bee-pollen healthcare toothpaste |
| CN103784336B (en) * | 2014-01-26 | 2016-06-29 | 泰州比尔夫生物科技有限公司 | A kind of toothpaste containing Bovine Lactoferrin |
| AU2015240385B2 (en) | 2014-04-01 | 2019-02-28 | Klox Technologies Inc. | Tissue filler compositions and methods of use |
| JP6755453B2 (en) * | 2015-01-16 | 2020-09-16 | 株式会社サンギ | Toothpaste composition |
| CN105381460B (en) * | 2015-11-05 | 2019-01-11 | 上海交通大学医学院附属第九人民医院 | A kind of anti-biotic material and its preparation and application |
| CN105769682A (en) * | 2016-04-03 | 2016-07-20 | 陶章菊 | Anti-cold toothpaste |
-
1998
- 1998-08-07 JP JP23633798A patent/JP4199333B2/en not_active Expired - Lifetime
- 1998-12-23 CN CNB981117139A patent/CN1169516C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104271143A (en) * | 2012-04-02 | 2015-01-07 | 克洛克斯科技公司 | Preventing or treating periodontal disease |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000053550A (en) | 2000-02-22 |
| JP4199333B2 (en) | 2008-12-17 |
| CN1244386A (en) | 2000-02-16 |
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