JP2887636B2 - Oral preparation - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oral preparation suitable for prevention, treatment or oral hygiene of various diseases such as caries, periodontitis, alveolar pyorrhea, and more particularly to an aqueous swelling gel of sodium-montmorillonite water. Sodium montmorillonii with addition of
And a novel oral preparation containing a urea complex as a main component.

[0002]

2. Description of the Related Art Conventionally, oral preparations for prevention, treatment or oral hygiene of tooth decay, periodontitis, alveolar pyorrhea, etc., are formulated with a hardening agent for tooth hard tissues such as fluoride. For example, fungicides, those that suppress bacteria that cause dental caries, such as antibiotics, those that suppress enzymes that feed on dental caries pathogens, such as antienzymatic agents, and those that further remove food residues, plaque, and tooth coloring Abrasives such as calcium phosphate and calcium carbonate, soluble chemicals, decomposing enzymes and the like are known. But,
There is no definitive oral preparation, and the emergence of a more effective internal preparation has been expected.

[0003]

DISCLOSURE OF THE INVENTION The present invention has been made in view of the above-mentioned circumstances, and has been made in consideration of the above circumstances. It is supplied to various affected areas in the oral cavity such as periodontitis generated based on the disease and alveolar purulence which is said to shift from the periodontitis, and includes bacteria in the oral cavity and toxins and metabolites generated from it・ Sodium is the most effective internal medicine that absorbs and also absorbs and absorbs the filthy organic substances present around each tooth, creating a clean environment in the oral cavity and healing the affected area. Urea to montmorillonite water swelling gel
It is an object of the present invention to provide a composition mainly composed of sodium montmorillonite and urea complex added . However, it is not intended to completely sterilize oral fungi such as streptococci. Oral bacteria, even if tired;
Inclusion of toxins, metabolites, plaque, tartar, etc. based on this
Its purpose is to remove after absorption. The present invention is not limited to toothpaste agents useful for the prevention and treatment of caries, periodontitis, alveolar pyorrhea, etc., but is also useful when applied as an oral gargling agent. The oral cavity preparation according to the present invention comprises sodium montmorillonite water-swelled body and urea added thereto.
PH 7.5 to 7.5 by the action of the morillonite and urea complex
It is controlled to an alkali side of 11.0, preferably 8.5 to 10.2, and effectively contributes to prevention and treatment of the oral cavity. That is, the fact that the urea complex is easily controlled to the alkali side is the reason why the oral preparation of the present invention is particularly useful for protection of dental caries. This is because streptococci such as Streptococcus mutans, which are called cariogenic bacteria, ferment ingested sugars and the like to form an acid in a short time, lower the pH in the oral cavity, and erode tooth enamel. The sodium-montmorillonite according to the present invention, an oral preparation containing a urea complex as a main component is extremely useful for creating an environment in which bacteria such as the above-mentioned Streptococcus mutans cannot survive in the oral cavity. I can say. That is, it is insoluble in water and quickly neutralizes the acid and maintains it on the alkali side. Since it has such an effect, it is also preferable to use it as a mouthwash for gargle.

[0004]

A urea is added to a natural or synthetic sodium-montmorillonite water-swelled gel.
The sodium-montmorillonite / urea complex is particularly useful as an oral preparation because it easily includes and binds to an organic substance having an amino group. That is, oral bacteria and waste products generated by the bacteria in the oral cavity are easily included, bound, and removed. Thus,
In order to solve the problem, the following five specific measures are provided.

[0005] First, one is: a. 1.0 part by weight of urea was added to 50 to 65 parts by weight of a relatively viscous gel of sodium montmorillonite containing 9 to 13% by weight of sodium montmorillonite.
Sodium-montmorillonite, a urea complex as a main component, b. Glycerin and / or sorbitol solution 30-4
0 parts by weight as a sweetener to increase the adaptability in the oral cavity c. In addition, if necessary, a small amount of kaolin as a bulking agent,
And adding a small amount of urea and a surfactant for pH adjustment and for enhancing inclusion / absorption, d. Furthermore, a composition comprising a small amount of a bactericide, e. pH 7.5 to 11.0, preferably 8.5 to 1
Controlled to 0.2 f. It is an oral agent applied to toothpaste,

[0006] Further, those having another prescription include g. To 50 to 65 parts by weight of a water-swelled gel of sodium montmorillonite having the same composition as above, 1.0 part by weight of urea was added.
25-35 parts by weight of glycerin and / or sorbitol solution is added to the added sodium -montmorillonite / urea complex , and if necessary, kaolin, a surfactant and the like are added thereto, and antibacterial action and anti- A composition comprising 4 to 8 parts by weight of a crude drug component having a relatively remarkable inflammatory action and astringent action, for example, horsetail extract or Otogiri extract, and further a small amount of a bacteriostatic agent, and having a pH of 7.5 to 11.0. ,Preferably,
Controlled to 8.5 to 10.2 h. An oral preparation applied to a toothpaste having an antibacterial, anti-inflammatory or astringent action. In addition, the crude drugs other than those described above,
Extracts such as Mannenrou, Salvia, Elderberry, Hamamelis, Burdock, Tachijasou, Gentian, Asenyaku, Touki, Emmeso or Clove can be used.

[0007] Further, those having another formulation include: i. Addition of 1.0 part by weight of urea to 50 to 56 parts by weight of a sodium-montmorillonite water swelling body having the composition of the above item g.
Sodium-montmorillonite, urea complex as a main component, glycerin and / or sorbitol solution 2
5 to 35 parts by weight and, if necessary, kaolin, urea and a surfactant, and a bacteriolytic preparation such as lysodium chloride, 1 part by weight or less, and a small amount of a bacteriostatic agent are added.
H is 7.5 to 11.0, preferably 8.5 to 10.2.
And j. It is an oral preparation mainly applied to dentifrices having a bacteriolytic action. In addition, as the preparation, in addition to the above, deoxyliponucleic acid, its sodium salt, liponucleic acid, its potassium salt and its sodium salt, etc. are preferably used.

[0008] Further, those having another formulation include: k. Urea is added to 55 to 70 parts by weight of a water-swelled gel body containing 6 to 10% by weight of sodium montmorillonite.
Sodium-montmorillonite, urea complex, 25-35 parts by weight of glycerin and / or sorbitol solution and, if necessary, kaolin and a surfactant are added, and preparation components such as potassium salt of deoxyribonucleic acid 3 parts by weight or less and crude drugs such as horsetail extract 3 parts by weight or less of a component, and a small amount of a bactericide. L. It is an oral preparation mainly applied to a toothpaste having a relatively strong anti-bacterial action, anti-inflammatory action or astringent action.

Further, as another formulation, m. Sodium montmorillonite Sodium prepared by adding urea to 88 to 93 parts by weight of a water-swelled gel of sodium montmorillonite contained at a relatively low concentration of 1 to 2% by weight.
・ Montmorillonite, a urea complex as a main component, 2 to 10 parts by weight of glycerin and / or sorbitol solution and 2 parts by weight of a crude drug component such as Otogiri extract, and, if necessary, kaolin, a surfactant, etc. A composition further comprising a small amount of a bacteriostat, wherein n. Oral preparations mainly applied to oral gargles,
Are useful.

Hereinafter, the present invention will be described based on examples. [Example 1] A paste-like oral preparation for oral use, which is used in the same manner as various conventional toothpaste preparations, and includes carbohydrates, lactic acid and other organic substances, bacteria, toxins and the like attached to teeth and gingival sulcus. Useful to absorb, absorb and eliminate out of the mouth. Purified water 51.1 Sodium montmorillonite 6.6 Kaolin 3.0 Urine 1.0 Sorbitol solution 15.0 Concentrated glycerin 20.0 Glycyrrhizin dipotassium 0.2 Surfactant 2.0 Bactericidal agent 0.7 ───計 Total 100.0 (parts by weight)

[Example 2] A crude drug is added to the composition, and it has a remarkable antibacterial action, anti-inflammatory action or astringent action. Purified water 53.0 Sodium montmorillonite 6.5 Kaolin 4.0 Urine 1.0 Sorbitol solution 12.0 Concentrated glycerin 15.0 Sugina extract 3.0 Otogiri extract 2.5 Surfactant 0.5────計 Total 100.0 (parts by weight)

[Example 3] A preparation is added to the composition, and a bacteriolytic action is markedly added. Purified water 59.8 Sodium montmorillonite 6.0 Kaolin 3.5 Urine 1.0 Sorbitol 12.0 Concentrated glycerin 15.0 Lysodium chloride 0.2 Surfactant 2.0 Bactericidal agent 0.5───計 Total 100.0 (parts by weight)

[0013]

Example 5 An oral gargle comprising a water-swellable gel containing sodium and montmorillonite at a low concentration. Purified water 90.2 Sodium montmorillonite 1.5 Kaolin 2.0 Urine 1.0 Glycerin 3.0 Otogiri extract 1.5 Surfactant 0.5 Bactericidal agent 0.3０．３計 Total 100.0 (parts by weight)

[0015]

According to the present invention, there is provided the present invention comprising sodium montmorillonite obtained by adding urea to a water-swelled sodium montmorillonite;
A urea complex , the sodium montmorillonite;
The urea complex, on the alkali side, prevents acid erosion by neutralizing acid, and the swollen body has a large function of enclosing and absorbing organic substances and the like, so that scum in the oral cavity can be reduced. Bacteria, toxins, etc. can be effectively included and absorbed to remove them and create a clean environment in the oral cavity, especially for the prevention and treatment of caries, periodontitis, alveolar pyorrhea, etc. It is an extremely useful invention having many advantages, such as being effective and providing good results as an oral gargle.

Continuation of the front page (56) References JP-A-3-271215 (JP, A) JP-A-60-75413 (JP, A) JP-A-63-153019 (JP, A) JP-A-52-54037 (JP, A) , A) JP-A-52-57339 (JP, A) "Known and used technology collection (cosmetics and similar products)", edited by the Japan Patent Office (pp. 118-122, 147, 157).

Claims (5)

(57) [Claims] 1. A sodium-montmorillonite / urea composite comprising 1 to 4 parts by weight of urea added to 50 to 93 parts by weight of a water-swelled gel of sodium-montmorillonite containing 1 to 15% by weight of sodium-montmorillonite. A composition in which the total of the components and the other components is 100 parts by weight, wherein the pH is controlled to 7.5 to 11.0, and the composition is applied to a toothpaste or an oral gargle. Internal preparation. 2. A sodium-montmorillonite-urea complex comprising 50 to 65 parts by weight of a water-swelled gel of sodium-montmorillonite containing 9 to 13% by weight of sodium-montmorillonite and 1 to 4 parts by weight of urea added thereto. Glycerin and / or sorbitol solution as an ingredient
40 parts by weight were added and the other components were added up to 10
A composition having a pH of 7.5 to 11.
An oral preparation characterized by being controlled to 0 and mainly applied to a normal toothpaste. 3. A sodium-montmorillonite / urea complex comprising 50 to 65 parts by weight of a water-swelled gel of sodium-montmorillonite containing 9 to 13% by weight of sodium-montmorillonite and 1 to 4 parts by weight of urea added thereto. Glycerin and / or sorbitol solution as an ingredient
A composition in which 35 parts by weight and 4 to 8 parts by weight of a crude drug component of a horsetail extract and a bellflower extract are added, and a total of 100 parts by weight of other components is added.
An oral preparation controlled at 1.0 and mainly applied to a toothpaste having an antibacterial action, an antiinflammatory action or an astringent action. 4. A sodium-montmorillonite urea composite obtained by adding 1 to 4 parts by weight of urea to 50 to 56 parts by weight of a water-swelled gel of sodium-montmorillonite containing 9 to 13% by weight of sodium-montmorillonite. age,
Glycerin and / or sorbitol solution is added to 25-35.
1 part by weight of lysozyme chloride and 1 part by weight of a lysozyme chloride component, and the total amount of other components is 100 parts by weight. The pH is controlled to 7.5 to 11.0, and the antibacterial activity is mainly obtained. An oral preparation characterized by being applied to a toothpaste having: 5. 1-2% by weight of sodium montmorillonite
Montmorillonite, a water-swelled gel of sodium-montmorillonite containing 88 to 93 parts by weight of urea and 1 to 4 parts by weight of urea, and a urea complex containing glycerin and / or sorbitol as a main component. It is a composition in which 2 parts by weight or less of a crude drug component of a cynomolgus extract and 100 parts by weight of other components are added, and the PH is controlled to 7.5 to 11.0, and the oral cavity is mainly used. An oral preparation characterized by being applied to a gargle.