CN103784336B - A kind of toothpaste containing Bovine Lactoferrin - Google Patents
A kind of toothpaste containing Bovine Lactoferrin Download PDFInfo
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- CN103784336B CN103784336B CN201410036847.5A CN201410036847A CN103784336B CN 103784336 B CN103784336 B CN 103784336B CN 201410036847 A CN201410036847 A CN 201410036847A CN 103784336 B CN103784336 B CN 103784336B
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- toothpaste
- bovine lactoferrin
- helicobacter pylori
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- lactoferrin
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Abstract
The invention discloses a kind of toothpaste containing Bovine Lactoferrin belonging to technical field of toothpaste.This toothpaste, is made up of the material of following parts by weight: dicalcium phosphate dihydrate 38-50 part, sorbitol 8-12 part, sodium laurylsulfate 2-4 part, Oleum menthae 0.5-1.5 part, glycerol 6-14 part, sodium carboxymethyl cellulose 1-2 part, sodium benzoate 1-1.5 part, water 20-35 part, Bovine Lactoferrin 0.2-2 part.The toothpaste of the present invention can effectively prevent the infection of oral cavity helicobacter pylori, and the Helicobacter pylori infection person having occurred and that is had certain therapeutic efficiency, the compositions active component lactoferrin of the present invention is the trophic factors that human body is useful, for a long time with having side effects, it it is a kind of safe substance.
Description
Technical field
The invention belongs to technical field of toothpaste, be specifically related to a kind of toothpaste containing Bovine Lactoferrin preventing Helicobacter pylori infection.
Background technology
Gastric ulcer, gastritis, the disease such as duodenal ulcer is all because infecting caused by helicobacter pylori.Main pathogenesis is: make helicobacter pylori penetrate the factor that rete malpighii is settled down on gastric epithelial cell surface；Gastric epithelial cell etc. is risen the toxin factor of destruction；Various inflammatory cells and inflammatory mediator；Immune-reactive substance etc..The microbial gastrointestinal disease of helicobacter pylorus is that a kind of refractory is healed, virulent disease, and along with the crowd infecting helicobacter pylori is continuously increased, the infection of prevention helicobacter pylori becomes a urgent task
As the saying goes, illness finds its way in by the mouth, and the patient of many infection helicobacter pyloris is due to improper diet, having infected the helicobacter pylori in food, helicobacter pylori is bred in the oral cavity, caused by being swallowed when having a meal or drink water, a part of antibacterial can be removed although brushing teeth, but allow and be so difficult to eradicate.
At present, market is badly in need of a kind of articles for daily use that can prevent in time to infect helicobacter pylori, toothpaste be a kind of people every day all can the articles for daily use, therefore, toothpaste adds prevention and infects the material of helicobacter pylori, be the way of a kind of good solution problem.
Bovine Lactoferrin is a kind of basic protein extracting from Lac Bovis seu Bubali, has multiple biological activity, develops the using value of this albumen, is a focus of research at present.
Summary of the invention
The present invention is directed to the gastrointestinal disease infecting helicobacter pylori at present to be difficult to effect a radical cure, it is easy to the problem of infection, it is proposed to a kind of toothpaste containing Bovine Lactoferrin.
A kind of toothpaste containing Bovine Lactoferrin, it is made up of the material of following parts by weight: dicalcium phosphate dihydrate 38-50 part, sorbitol 8-12 part, sodium laurylsulfate 2-4 part, Oleum menthae 0.5-1.5 part, glycerol 6-14 part, sodium carboxymethyl cellulose 1-2 part, sodium benzoate 1-1.5 part, water 20-35 part, Bovine Lactoferrin 0.2-2 part.
Preferably, the described toothpaste containing Bovine Lactoferrin is made up of the material of following parts by weight: dicalcium phosphate dihydrate 44 parts, sorbitol 10 parts, sodium laurylsulfate 3 parts, Oleum menthae 1 part, glycerol 10 parts, sodium carboxymethyl cellulose 1.5 parts, sodium benzoate 0.5 part, 28 parts of water, Bovine Lactoferrin 1 part.
Preferably, the described toothpaste containing Bovine Lactoferrin is made up of the material of following parts by weight: dicalcium phosphate dihydrate 40 parts, sorbitol 10 parts, sodium laurylsulfate 3 parts, Oleum menthae 1 part, glycerol 10 parts, sodium carboxymethyl cellulose 1.5 parts, sodium benzoate 0.5 part, 28 parts of water, Bovine Lactoferrin 6 parts.
The application in prevention Helicobacter pylori infection of the above-mentioned toothpaste containing Bovine Lactoferrin.
Beneficial effects of the present invention: the toothpaste of the present invention can effectively prevent Helicobacter pylori infection, and the gastroenteropathy of the Helicobacter pylori infection having occurred and that there is is certain therapeutic efficiency, the compositions active component lactoferrin of the present invention is the trophic factors that human body is useful, for a long time with having side effects, it it is a kind of safe substance.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention will be further described.
Embodiment 1
A kind of toothpaste containing Bovine Lactoferrin, is made up of following material: dicalcium phosphate dihydrate 44g, sorbitol 10g, sodium laurylsulfate 3g, Oleum menthae 1g, glycerol 10g, sodium carboxymethyl cellulose 1.5g, sodium benzoate 0.5g, water 28g, Bovine Lactoferrin 1g.
Embodiment 2
A kind of toothpaste containing Bovine Lactoferrin, is made up of following material: dicalcium phosphate dihydrate 40g, sorbitol 10g, sodium laurylsulfate 3g, Oleum menthae 1g, glycerol 10g, sodium carboxymethyl cellulose 1.5g, sodium benzoate 0.5g, water 28g, Bovine Lactoferrin 6g.
Embodiment 3
A kind of toothpaste containing Bovine Lactoferrin, is made up of following material: dicalcium phosphate dihydrate 38g, sorbitol 8g, sodium laurylsulfate 2g, Oleum menthae 0.5g, glycerol 6g, sodium carboxymethyl cellulose 1g, sodium benzoate 1g, water 20g, Bovine Lactoferrin 0.2g.
Embodiment 4
A kind of toothpaste containing Bovine Lactoferrin, is made up of following material: dicalcium phosphate dihydrate 50g, sorbitol 12g, sodium laurylsulfate 4g, Oleum menthae 1.5g, glycerol 14g, sodium carboxymethyl cellulose 2g, sodium benzoate 1.5g, water 35g, Bovine Lactoferrin 2g.
Embodiment 5
Gastric ulcer Experiment on therapy method: select the patients w ith peptic ulcer disease of 80 example helicobacter pylori infections, it is divided into treatment group (40 example) and matched group (40 example), treatment group adopts the toothpaste of embodiment 1 to brush teeth, every day 2 times, each consumption 2g, matched group adopts omeprazole, taking every day 2 times, each take 20mg, treatment cycle is 6 months, after 6 months, comparison therapy effect.
Gastric ulcer Experiment on therapy result: treatment group and matched group gastric ulcer treatment clearance respectively 70.1% and 69.9%, matched group and treatment group do not have obvious difference, it was demonstrated that these cosmetics can reach effectively to prevent and suppress helicobacter pylori infection effect.
Embodiment 6
A kind of toothpaste containing Bovine Lactoferrin, is made up of following material: dicalcium phosphate dihydrate 44g, sorbitol 10g, sodium laurylsulfate 3g, little Herba chenopodii extract 3 parts, Oleum menthae 1g, glycerol 10g, sodium carboxymethyl cellulose 1.5g, sodium benzoate 0.5g, water 28g, Bovine Lactoferrin 1g.
The preparation method of described little Herba chenopodii extract: dried by little Herba chenopodii, pulverizes, and loads to decoct and soaks 4-10h in bag, moves in Decocting pot, decoct 4-9h when temperature 80-110 degree, finally by decoction liquor powder by spraying, obtain little Herba chenopodii extract.
Above-mentioned composition is except suppressing helicobacter pylori infections, it is also possible to prevention and treatment dental caries tooth disease, periodontitis, and experimental verification is as follows:
Gastric ulcer Experiment on therapy method: select the patients w ith peptic ulcer disease of 80 example helicobacter pylori infections, it is divided into treatment group (40 example) and matched group (40 example), treatment group adopts the toothpaste of the present embodiment to brush teeth, every day 2 times, each consumption 2g, matched group adopts omeprazole, taking every day 2 times, each take 20mg, treatment cycle is 6 months, after 6 months, comparison therapy effect.
Gastric ulcer Experiment on therapy result: treatment group and matched group gastric ulcer treatment clearance respectively 72.1% and 71.7%, matched group and treatment group do not have obvious difference, it was demonstrated that these cosmetics can reach effectively to prevent and suppress helicobacter pylori infection effect.
The toothpaste made is divided into two groups, and one group carries out dental caries tooth disease Experiment on therapy, and one group carries out periodontitis and improves experiment.
Dental caries tooth disease Experiment on therapy method: select 80 example dental caries tooth disease patients, it is divided into treatment group (40 example) and matched group (40 example), treatment group adopts the toothpaste of embodiment 1 to brush teeth, every day 2 times (sooner or later respectively once), matched group adopts tetracycline antibiotic conventional therapy, medication every day 2 times, treatment cycle is 3 months, and drug withdrawal added up relapse rate after 1 month.
Dental caries tooth disease Experiment on therapy result: the relapse rate for the treatment of group and matched group dental caries tooth disease respectively 11.3% and 11.6%, treatment group and matched group no significant difference, prove that prevention and treatment dental caries tooth disease are had good effect by this dentifrice composition, it was demonstrated that little Herba chenopodii extract serves effective effect wherein.
Periodontitis improves experimental technique: select the 80 cases suffering from periodontitis, age is between 45-55 year, the toothpaste adopting embodiment 1 is brushed teeth, every day 2 times (sooner or later respectively once), after brushing teeth 3 months, periodontitis elimination factor is 10%, periodontitis elimination factor after half a year of brushing teeth is 40%, and after brushing teeth 1 year, periodontitis elimination factor is 90%, and after a year and a half of brushing teeth, periodontitis elimination factor is 90%.Above-mentioned experiment proves that periodontitis is had certain preventive and therapeutic action by said composition, it was demonstrated that little Herba chenopodii extract serves effective effect wherein.
Claims (1)
1. the toothpaste containing Bovine Lactoferrin, it is characterised in that be made up of following material: dicalcium phosphate dihydrate 44g, sorbitol 10g, sodium laurylsulfate 3g, little Herba chenopodii extract 3g, Oleum menthae 1g, glycerol 10g, sodium carboxymethyl cellulose 1.5g, sodium benzoate 0.5g, water 28g, Bovine Lactoferrin 1g；
The preparation method of described little Herba chenopodii extract: dried by little Herba chenopodii, pulverizes, and loads to decoct and soaks 4-10h in bag, moves in Decocting pot, decoct 4-9h when temperature 80-110 degree, finally by decoction liquor powder by spraying, obtain little Herba chenopodii extract.
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| CN201410036847.5A CN103784336B (en) | 2014-01-26 | 2014-01-26 | A kind of toothpaste containing Bovine Lactoferrin |
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| CN103784336A CN103784336A (en) | 2014-05-14 |
| CN103784336B true CN103784336B (en) | 2016-06-29 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10172786B2 (en) * | 2014-12-16 | 2019-01-08 | Axim Biotechnologies, Inc. | Oral care composition comprising cannabinoids |
| CN105434264B (en) * | 2015-12-22 | 2018-06-29 | 南昌理工学院 | A kind of motherwort toothpaste |
| CN107753317A (en) * | 2016-08-22 | 2018-03-06 | 上海利康消毒高科技有限公司 | A kind of Chinese herbaceous peony and chamomile mixed essential oil dentistry postoperative care toothpaste |
| CN109498542A (en) * | 2018-12-29 | 2019-03-22 | 泰州优克生物科技有限公司 | A kind of biological toothpaste for anti-helicobacter pylori |
| CN110075036A (en) * | 2019-06-17 | 2019-08-02 | 广东天丝饮料有限公司 | Anti- oral helicobacter pylori medicated toothpaste |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1244386A (en) * | 1998-08-07 | 2000-02-16 | 青木秀希 | Oral cleaning detergent component and tooth-paste, tooth powder component |
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2014
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1244386A (en) * | 1998-08-07 | 2000-02-16 | 青木秀希 | Oral cleaning detergent component and tooth-paste, tooth powder component |
Non-Patent Citations (1)
| Title |
|---|
| 专利文摘;骆希明;《牙膏工业》;20031231(第3期);第53-58页 * |
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Effective date of registration: 20170427 Address after: 230000 Anhui, Hefei innovation Avenue, race for the building 666 Patentee after: HEFEI SUNWIN SMART HEALTHCARE CO., LTD. Address before: Room 1, building 168, Fenghuang West Road, Jiangsu, Taizhou, 225300, China Patentee before: TAIZHOU BIERFU BIOLOGICAL SCIENCE & TECHNOLOGY CO., LTD. |
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Effective date of registration: 20200713 Address after: 230000 south, 4th floor, Saiwei building, NO.666, innovation Avenue, hi tech Zone, Hefei City, Anhui Province Patentee after: Hefei bilf Biotechnology Co., Ltd Address before: 230000 Anhui, Hefei innovation Avenue, race for the building 666 Patentee before: HEFEI SUNWIN SMART HEALTHCARE Co.,Ltd. |