CN107898705B - A collutory for preventing dental caries and oral ulcer, and its preparation method - Google Patents
A collutory for preventing dental caries and oral ulcer, and its preparation method Download PDFInfo
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- CN107898705B CN107898705B CN201711396145.8A CN201711396145A CN107898705B CN 107898705 B CN107898705 B CN 107898705B CN 201711396145 A CN201711396145 A CN 201711396145A CN 107898705 B CN107898705 B CN 107898705B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Abstract
The invention belongs to the technical field of oral health care, and particularly relates to mouthwash capable of preventing dental caries and oral ulcer, which comprises the following raw materials in parts by weight: 5-10 parts of catechin, 5-10 parts of grape polyphenol, 15-20 parts of gingerol, 8-15 parts of chamomile hydrolat, 8-8 parts of vitamin C3, 4-10 parts of folic acid, 1-3 parts of sweetener, 15-20 parts of traditional Chinese medicine extract and 10-20 parts of tea extract. The mouthwash provided by the invention is prepared from pure natural raw materials, is safe, healthy, nontoxic and harmless, can be used as a daily care product for a long time, can effectively remove bacteria in a cavity, has a good effect of preventing dental caries and oral ulcer, and has no side effect on a human body after long-term use.
Description
Technical Field
The invention belongs to the technical field of oral health care, and particularly relates to mouthwash capable of preventing dental caries and oral ulcer and a preparation method thereof.
Background
With the ever-increasing standard of living, more and more people begin to focus on oral health, with dental caries and canker sores being the most common oral diseases. Dental caries is a bacterial disease, so that it can cause secondary pulpitis and periapical periodontitis, even alveolar bone and jaw inflammation, and secondary infection of dental caries can form a focus, so that arthritis, cardia periostitis, chronic kidney disease, various eye diseases and other diseases of the whole body can be caused or added. Oral ulcer is a common ulcerative injury disease occurring in oral mucosa, which is mostly seen in the inner side of lips, tongue abdomen, buccal mucosa, vestibular groove, soft palate and other parts, and the pathogenesis of oral ulcer is the result of the comprehensive action of multiple factors, wherein the pathogenesis of bacteria such as streptococcus sanguis, helicobacter pylori and the like is closely related to the pathogenesis of oral ulcer.
The most effective method for preventing decayed teeth and oral ulcers is to kill bacteria and keep oral hygiene, a plurality of mouthwashes with different components appear on the market, most of the mouthwashes in the prior art contain components such as triclosan or a nail-nitrate file and the like to enhance the sterilization and bacteriostasis effects of the mouthwashes, however, the components can cause certain damage to human bodies after long-term use, and therefore, the mouthwashes are not suitable for long-term use as daily oral care products.
Disclosure of Invention
The invention aims to solve the technical problem of developing the mouthwash capable of preventing dental caries and dental ulcer, and the specific technical scheme is as follows:
a mouthwash capable of preventing dental caries and oral ulcer comprises the following raw materials in parts by weight: 5-10 parts of catechin, 5-10 parts of grape polyphenol, 15-20 parts of gingerol, 8-15 parts of chamomile hydrolat, 8-8 parts of vitamin C3, 4-10 parts of folic acid, 1-3 parts of a sweetening agent, 15-20 parts of a traditional Chinese medicine extract and 10-20 parts of a tea extract, wherein the traditional Chinese medicine extract comprises the following raw materials in parts by weight: 5-10 parts of picrorhiza rhizome, 5-10 parts of honeysuckle, 1-5 parts of fructus forsythiae, 4-8 parts of common andrographis herb, 5-10 parts of liquorice and 3-8 parts of Chinese gall, wherein the tea extract comprises the following raw materials in parts by weight: 5-10 parts of green tea, 5-10 parts of oolong tea and 5-10 parts of broadleaf holly leaf.
Preferably, the mouthwash capable of preventing dental caries and oral ulcer comprises the following raw materials in parts by weight: 9 parts of catechin, 6 parts of grape polyphenol, 15 parts of gingerol, 13 parts of chamomile hydrolat, 3 parts of vitamin C, 4 parts of folic acid, 1 part of sweetener, 20 parts of traditional Chinese medicine extract and 20 parts of tea extract.
Preferably, the traditional Chinese medicine extract comprises the following raw materials in parts by weight: 5 parts of picrorhiza rhizome, 8 parts of honeysuckle, 4 parts of forsythia, 6 parts of common andrographis herb, 8 parts of liquorice and 5 parts of gallnut.
Preferably, the tea extract comprises the following raw materials in parts by weight: 10 parts of green tea, 5 parts of oolong tea and 5 parts of broadleaf holly leaf.
Preferably, the traditional Chinese medicine extract is prepared by the following method: mixing the components, crushing to 50 meshes, adding water according to the weight ratio of 1:2, uniformly mixing, then adding yeast with the weight fraction of 0.5% and cellulase with the weight fraction of 0.8%, mixing, fermenting at 35 ℃ for 72 hours, adding an equal weight of ethanol solution with the mass fraction of 30%, stirring for 5 hours, filtering, sterilizing, and distilling the filtrate under reduced pressure to remove ethanol to obtain the traditional Chinese medicine extract.
Preferably, the tea extract is prepared by the following method: adding tea into water, wherein the weight ratio of the tea to the water is 1: 3, boiling for 5 hours, cooling to 35-40 ℃, adding yeast with the weight percentage of 0.2-0.5%, uniformly mixing, standing for 72 hours at 35-40 ℃, adding an equal weight of ethanol solution with the mass percentage of 30%, stirring for 4 hours, filtering, sterilizing, and distilling the filtrate under reduced pressure to remove ethanol to obtain the tea extract.
Preferably, the sweetener is aspartame or xylitol.
Preferably, the biological preservative also comprises 0.02 part and 0.1 part of biological bacteriostatic agent.
Preferably, the biological preservative consists of 50 wt% potassium sorbate and 50 wt% sodium sorbate.
Preferably, the biological bacteriostatic agent is chitosan.
The preparation method of the mouthwash for preventing dental caries and oral ulcer comprises the following steps: adding catechin, grape polyphenol, gingerol, vitamins, folic acid, a sweetening agent, a biological preservative and a biological bacteriostatic agent into deionized water, and uniformly stirring, wherein the weight ratio of the raw materials to the water is 1: 3, heating to 40-50 ℃, stirring for 3h, then sequentially adding chamomile hydrolat, traditional Chinese medicine extract and tea extract, stirring uniformly, and cooling to room temperature to obtain the mouthwash capable of preventing dental caries and oral ulcer.
The use method of the mouthwash provided by the invention comprises the following steps: 5-10ml for children and 10-20ml for adults after breakfast and supper for 30s, and spitting out. The product can be used without rinsing mouth. Do not eat within half an hour to avoid reducing the effect.
The invention has the advantages of
(1) The mouthwash provided by the invention is prepared from pure natural raw materials, is safe, healthy, nontoxic and harmless, can be used as a daily care product for a long time, can effectively remove bacteria in the oral cavity, has a good effect of preventing dental caries and oral ulcer, and does not have any side effect on a human body after long-term use.
(2) In the mouthwash of the invention, catechin can play a better role in antibiosis, bacteriostasis and deodorization; the grape polyphenol has stronger antioxidant effect; gingerol is the main active ingredient in ginger, and has antioxidant and antibacterial effects; the chamomile hydrolat not only has the effects of reducing internal heat and diminishing inflammation, but also has the function of refreshing breath; the vitamins and folic acid can effectively prevent oral ulcer; the sweetening agent can neutralize the bitter taste of the traditional Chinese medicine, so that the mouth wash has better taste; the traditional Chinese medicine extract adopts traditional Chinese medicines with antibacterial and anti-inflammatory functions, can effectively kill oral bacteria, can play a role in preventing dental caries and oral ulcer, and can play a role in preventing corrosion by the selected traditional Chinese medicine components; the tea extract is rich in catechin and polyphenol, has antioxidant and antibacterial effects, and can neutralize the taste of mouthwash to make the tea fragrant, the tea extract is prepared from green tea, oolong tea and ilex latifolia thumb, the green tea is rich in catechin, the oolong tea is rich in polyphenol after fermentation, and the ilex latifolia thumb has good effects of reducing pathogenic fire and diminishing inflammation.
Detailed Description
Example 1
A mouthwash capable of preventing dental caries and oral ulcer comprises the following raw materials in parts by weight: 9 parts of catechin, 6 parts of grape polyphenol, 15 parts of gingerol, 13 parts of chamomile hydrolat, 3 parts of vitamin C, 4 parts of folic acid, 1 part of sweetener, 20 parts of traditional Chinese medicine extract and 20 parts of tea extract. The traditional Chinese medicine extract comprises the following raw materials in parts by weight: 5 parts of picrorhiza rhizome, 8 parts of honeysuckle, 4 parts of forsythia, 6 parts of common andrographis herb, 8 parts of liquorice and 5 parts of gallnut. The tea extract comprises the following raw materials in parts by weight: 10 parts of green tea, 5 parts of oolong tea and 5 parts of broadleaf holly leaf.
The preparation method of the mouthwash for preventing dental caries and oral ulcer comprises the following steps: adding catechin, grape polyphenol, gingerol, vitamins, folic acid and a sweetening agent into deionized water, and uniformly stirring, wherein the weight ratio of the raw materials to the water is 1: 3, heating to 40-50 ℃, stirring for 3h, then sequentially adding chamomile hydrolat, traditional Chinese medicine extract and tea extract, stirring uniformly, and cooling to room temperature to obtain the mouthwash capable of preventing dental caries and oral ulcer.
Example 2
A mouthwash capable of preventing dental caries and oral ulcer comprises the following raw materials in parts by weight: 5 parts of catechin, 5 parts of grape polyphenol, 15 parts of gingerol, 8 parts of chamomile hydrolat, 3 parts of vitamin C, 4 parts of folic acid, 1 part of sweetener, 15 parts of traditional Chinese medicine extract and 10 parts of tea extract, wherein the traditional Chinese medicine extract comprises the following raw materials in parts by weight: 5 parts of picrorhiza rhizome, 5 parts of honeysuckle, 1 part of forsythia, 4 parts of common andrographis herb, 5 parts of liquorice and 3 parts of gallnut, wherein the tea extract comprises the following raw materials in parts by weight: 5 parts of green tea, 5 parts of oolong tea and 5 parts of broadleaf holly leaf.
The preparation method of the mouthwash for preventing dental caries and oral ulcer comprises the following steps: adding catechin, grape polyphenol, gingerol, vitamins, folic acid and a sweetening agent into deionized water, and uniformly stirring, wherein the weight ratio of the raw materials to the water is 1: 3, heating to 40-50 ℃, stirring for 3h, then sequentially adding chamomile hydrolat, traditional Chinese medicine extract and tea extract, stirring uniformly, and cooling to room temperature to obtain the mouthwash capable of preventing dental caries and oral ulcer.
Example 3
A mouthwash capable of preventing dental caries and oral ulcer comprises the following raw materials in parts by weight: 10 parts of catechin, 10 parts of grape polyphenol, 20 parts of gingerol, 15 parts of chamomile hydrolat, 8 parts of vitamin C, 10 parts of folic acid, 3 parts of sweetening agent, 20 parts of traditional Chinese medicine extract and 20 parts of tea extract, wherein the traditional Chinese medicine extract comprises the following raw materials in parts by weight: 10 parts of picrorhiza rhizome, 10 parts of honeysuckle, 5 parts of fructus forsythiae, 8 parts of common andrographis herb, 10 parts of liquorice and 8 parts of Chinese gall, wherein the tea extract comprises the following raw materials in parts by weight: 10 parts of green tea, 10 parts of oolong tea and 10 parts of broadleaf holly leaf.
The traditional Chinese medicine extract is prepared by the following method: mixing the components, crushing to 50 meshes, adding water according to the weight ratio of 1:2, uniformly mixing, then adding yeast with the weight fraction of 0.5% and cellulase with the weight fraction of 0.8%, mixing, fermenting at 35 ℃ for 72 hours, adding an equal weight of ethanol solution with the mass fraction of 30%, stirring for 5 hours, filtering, sterilizing, and distilling the filtrate under reduced pressure to remove ethanol to obtain the traditional Chinese medicine extract.
Example 4
A mouthwash capable of preventing dental caries and oral ulcer comprises the following raw materials in parts by weight: 6 parts of catechin, 9 parts of grape polyphenol, 18 parts of gingerol, 10 parts of chamomile hydrolat, 5 parts of vitamin C, 5 parts of folic acid, 2 parts of sweetener, 19 parts of traditional Chinese medicine extract and 15 parts of tea extract, wherein the traditional Chinese medicine extract comprises the following raw materials in parts by weight: the tea comprises, by weight, 6 parts of picrorhiza rhizome, 6 parts of honeysuckle, 3 parts of fructus forsythiae, 5 parts of common andrographis herb, 8 parts of liquorice and 7 parts of gallnut, wherein the tea extract comprises the following raw materials: 8 parts of green tea, 6 parts of oolong tea and 5 parts of broadleaf holly leaf.
The tea extract is prepared by the following method: adding tea into water, wherein the weight ratio of the tea to the water is 1: 3, boiling for 5 hours, cooling to 35-40 ℃, adding 0.2% by weight of yeast, uniformly mixing, standing for 72 hours at 35-40 ℃, adding 30% by weight of ethanol solution, stirring for 4 hours, filtering, sterilizing, and distilling the filtrate under reduced pressure to remove ethanol to obtain the tea extract.
Example 5
A mouthwash capable of preventing dental caries and oral ulcer comprises the following raw materials in parts by weight: 8 parts of catechin, 7 parts of grape polyphenol, 17 parts of gingerol, 14 parts of chamomile hydrolat, 7 parts of vitamin C, 5 parts of folic acid, 1 part of aspartame, 16 parts of traditional Chinese medicine extract, 10 parts of tea extract, 0.02 part of biological preservative and 0.1 part of biological bacteriostatic agent, wherein the biological preservative consists of 50 wt% of potassium sorbate and 50 wt% of sodium sorbate, and the biological bacteriostatic agent is chitosan.
The traditional Chinese medicine extract comprises the following raw materials in parts by weight: the tea comprises 9 parts of picrorhiza rhizome, 8 parts of honeysuckle, 4 parts of fructus forsythiae, 7 parts of common andrographis herb, 9 parts of liquorice and 7 parts of gallnut, wherein the tea extract comprises the following raw materials in parts by weight: 9 parts of green tea, 9 parts of oolong tea and 6 parts of broadleaf holly leaf.
The traditional Chinese medicine extract is prepared by the following method: mixing the components, crushing to 50 meshes, adding water according to the weight ratio of 1:2, uniformly mixing, then adding yeast with the weight fraction of 0.5% and cellulase with the weight fraction of 0.8%, mixing, fermenting at 35 ℃ for 72 hours, adding an equal weight of ethanol solution with the mass fraction of 30%, stirring for 5 hours, filtering, sterilizing, and distilling the filtrate under reduced pressure to remove ethanol to obtain the traditional Chinese medicine extract.
Preferably, the tea extract is prepared by the following method: adding tea into water, wherein the weight ratio of the tea to the water is 1: 3, boiling for 5 hours, cooling to 35-40 ℃, adding 0.5 wt% of yeast, uniformly mixing, standing for 72 hours at 35-40 ℃, adding 30 wt% of ethanol solution, stirring for 4 hours, filtering, sterilizing, and distilling the filtrate under reduced pressure to remove ethanol to obtain the tea extract.
The preparation method of the mouthwash for preventing dental caries and oral ulcer comprises the following steps: adding catechin, grape polyphenol, gingerol, vitamins, folic acid, a sweetening agent, a biological preservative and a biological bacteriostatic agent into deionized water, and uniformly stirring, wherein the weight ratio of the raw materials to the water is 1: 3, heating to 40-50 ℃, stirring for 3h, then sequentially adding chamomile hydrolat, traditional Chinese medicine extract and tea extract, stirring uniformly, and cooling to room temperature to obtain the mouthwash capable of preventing dental caries and oral ulcer.
Examples of the experiments
To verify the efficacy of the mouthwashes of the present invention, the following experiments were conducted on the mouthwashes obtained in examples 1-5.
Test subjects: the experimental group was the mouth wash obtained in examples 1 to 5, and the control group was 0.9% by mass of physiological saline.
1. Antibacterial experiments
Test bacteria: candida albicans, Streptococcus sanguis, Streptococcus mutans, Actinomyces viscosus, Staphylococcus aureus, and Escherichia coli.
The test method comprises the following steps: an antibacterial test is carried out by referring to GB15979-2002 appendix C3, and the antibacterial rate is (the number of the live bacteria in the control group-the number of the live bacteria in the experimental group)/the number of the live bacteria in the control group.
The test results are shown in table 1.
TABLE 1 bacteriostatic ratio of mouthwashes obtained in examples 1 to 5
Test results show that the mouthwash disclosed by the invention has a good bacteriostatic effect on candida albicans, streptococcus sanguis, streptococcus mutans, actinomyces viscosus, staphylococcus aureus and escherichia coli.
2. Anti-inflammatory test
The test method comprises the following steps: 120 mice were divided into 6 groups at random, each group had 20 mice, and the left ear of the mice was smeared with 20ul xylene, 1ml of the mouth wash obtained in examples 1 to 5 was smeared uniformly on the inflamed part of the left ear after 1 hour, 30min was performed once and 3 times continuously, the right ear was not treated, the mice were sacrificed after 3 hours, the same part of the ear piece was weighed, and the swelling rate was calculated. The swelling rate (left ear weight-right ear weight)/right ear weight was averaged and the results are shown in table 2.
TABLE 2 anti-inflammatory Effect of the mouthwashes obtained in examples 1 to 5
The data in the table show that the mouthwash of the invention has better anti-inflammatory effect.
Claims (10)
1. The mouthwash capable of preventing dental caries and oral ulcer is characterized by comprising the following raw materials in parts by weight: 5-10 parts of catechin, 5-10 parts of grape polyphenol, 15-20 parts of gingerol, 8-15 parts of chamomile hydrolat, 8-8 parts of vitamin C3, 4-10 parts of folic acid, 1-3 parts of a sweetening agent, 15-20 parts of a traditional Chinese medicine extract and 10-20 parts of a tea extract, wherein the traditional Chinese medicine extract comprises the following raw materials in parts by weight: 5-10 parts of picrorhiza rhizome, 5-10 parts of honeysuckle, 1-5 parts of fructus forsythiae, 4-8 parts of common andrographis herb, 5-10 parts of liquorice and 3-8 parts of Chinese gall, wherein the tea extract comprises the following raw materials in parts by weight: 5-10 parts of green tea, 5-10 parts of oolong tea and 5-10 parts of broadleaf holly leaf.
2. The mouthwash capable of preventing dental caries and oral ulcer according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 9 parts of catechin, 6 parts of grape polyphenol, 15 parts of gingerol, 13 parts of chamomile hydrolat, 3 parts of vitamin C, 4 parts of folic acid, 1 part of sweetener, 20 parts of traditional Chinese medicine extract and 20 parts of tea extract.
3. The mouthwash capable of preventing dental caries and oral ulcer according to claim 1, wherein the traditional Chinese medicine extract comprises the following raw materials in parts by weight: 5 parts of picrorhiza rhizome, 8 parts of honeysuckle, 4 parts of forsythia, 6 parts of common andrographis herb, 8 parts of liquorice and 5 parts of gallnut.
4. The mouthwash for preventing dental caries and oral ulcer according to claim 1, wherein the tea extract comprises the following raw materials in parts by weight: 10 parts of green tea, 5 parts of oolong tea and 5 parts of broadleaf holly leaf.
5. The mouthwash for preventing dental caries and oral ulcer according to claim 1, wherein the Chinese herbal medicine extract is prepared by the following method: mixing the components, crushing to 50 meshes, adding water according to the weight ratio of 1:2, uniformly mixing, then adding yeast with the weight fraction of 0.5% and cellulase with the weight fraction of 0.8%, mixing, fermenting at 35 ℃ for 72 hours, adding an equal weight of ethanol solution with the mass fraction of 30%, stirring for 5 hours, filtering, sterilizing, and distilling the filtrate under reduced pressure to remove ethanol to obtain the traditional Chinese medicine extract.
6. The mouthwash for preventing dental caries and oral ulcer according to claim 1, wherein the tea extract is prepared by the following method: adding tea into water, wherein the weight ratio of the tea to the water is 1: 3, boiling for 5 hours, cooling to 35-40 ℃, adding yeast with the weight percentage of 0.2-0.5%, uniformly mixing, standing for 72 hours at 35-40 ℃, adding an equal weight of ethanol solution with the mass percentage of 30%, stirring for 4 hours, filtering, sterilizing, and distilling the filtrate under reduced pressure to remove ethanol to obtain the tea extract.
7. A mouthwash according to claim 1, for preventing dental caries and oral ulcers, characterized by: the sweetener is aspartame or xylitol.
8. A mouthwash according to claim 1, for preventing dental caries and oral ulcers, characterized by: also comprises 0.02 part of biological preservative and 0.1 part of biological bacteriostatic agent.
9. A mouthwash according to claim 8, for preventing dental caries and oral ulcers, characterized by: the biological preservative is composed of 50 wt% potassium sorbate and 50 wt% sodium sorbate, and the biological bacteriostatic agent is chitosan.
10. The method for preparing a mouthwash according to claim 8 or 9, for preventing dental caries and oral ulcers, comprising: adding catechin, grape polyphenol, gingerol, vitamin C, folic acid, a sweetening agent, a biological preservative and a biological bacteriostatic agent into deionized water, and uniformly stirring, wherein the weight ratio of the raw materials to the water is 1: 3, heating to 40-50 ℃, stirring for 3h, then sequentially adding chamomile hydrolat, traditional Chinese medicine extract and tea extract, stirring uniformly, and cooling to room temperature to obtain the mouthwash capable of preventing dental caries and oral ulcer.
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4188326B2 (en) * | 2005-02-10 | 2008-11-26 | アース製薬株式会社 | Liquid oral composition |
| CN103315938A (en) * | 2013-07-12 | 2013-09-25 | 孙佳丽 | Anti-oxidative mouthwash |
| JP5750675B2 (en) * | 2011-02-18 | 2015-07-22 | ユースキン製薬株式会社 | Oral composition |
| CN105395467A (en) * | 2015-12-01 | 2016-03-16 | 山东皓尔生物工程有限公司 | Traditional Chinese medicinal composition, skin-care cosmetic and application of skin-care cosmetic |
| CN106491725A (en) * | 2016-12-30 | 2017-03-15 | 郑州掌盟网络科技有限公司 | A kind of treat pharmaceutical composition of oral ulcer and preparation method thereof |
| CN107184476A (en) * | 2017-06-16 | 2017-09-22 | 河北康正药业有限公司 | A kind of antibacterial mouthwash and preparation method thereof |
| CN107296763A (en) * | 2017-09-11 | 2017-10-27 | 佛山市聚成生化技术研发有限公司 | A kind of mouthwash containing gingerol |
-
2017
- 2017-12-21 CN CN201711396145.8A patent/CN107898705B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4188326B2 (en) * | 2005-02-10 | 2008-11-26 | アース製薬株式会社 | Liquid oral composition |
| JP5750675B2 (en) * | 2011-02-18 | 2015-07-22 | ユースキン製薬株式会社 | Oral composition |
| CN103315938A (en) * | 2013-07-12 | 2013-09-25 | 孙佳丽 | Anti-oxidative mouthwash |
| CN105395467A (en) * | 2015-12-01 | 2016-03-16 | 山东皓尔生物工程有限公司 | Traditional Chinese medicinal composition, skin-care cosmetic and application of skin-care cosmetic |
| CN106491725A (en) * | 2016-12-30 | 2017-03-15 | 郑州掌盟网络科技有限公司 | A kind of treat pharmaceutical composition of oral ulcer and preparation method thereof |
| CN107184476A (en) * | 2017-06-16 | 2017-09-22 | 河北康正药业有限公司 | A kind of antibacterial mouthwash and preparation method thereof |
| CN107296763A (en) * | 2017-09-11 | 2017-10-27 | 佛山市聚成生化技术研发有限公司 | A kind of mouthwash containing gingerol |
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