CN106491725A - A kind of treat pharmaceutical composition of oral ulcer and preparation method thereof - Google Patents

A kind of treat pharmaceutical composition of oral ulcer and preparation method thereof Download PDF

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Publication number
CN106491725A
CN106491725A CN201611252652.XA CN201611252652A CN106491725A CN 106491725 A CN106491725 A CN 106491725A CN 201611252652 A CN201611252652 A CN 201611252652A CN 106491725 A CN106491725 A CN 106491725A
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parts
vitamin
yinqiao
pharmaceutical composition
oral ulcer
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不公告发明人
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Zhengzhou Palm Network Technology Co Ltd
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Zhengzhou Palm Network Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Insects & Arthropods (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention discloses a kind of pharmaceutical composition for treating oral ulcer, is made up of according to weight portion following raw material：26 parts of 25 parts of Radix Scutellariae, 4 10 parts of Flos Lonicerae, 2 10 parts of YINQIAO, 0.5 4 parts of magnesium stearate, 0.2 1.5 parts of prednisone, 26 parts of levamisole, 1.5 3 parts of Folic Acid, 36 parts of vitamin C, 14 parts of metronidazole, 4 10 parts of Mel and chlorhexidine.The present invention also disclosed the preparation method of the medicine.Raw material sources of the present invention are extensive, preparation process is simple, it is adaptable to large-scale industrial production；In the present invention, each component plays synergism, easy to use, plays blood stasis dispelling, disappear the functions such as routed, hemostasis, pain relieving, heat clearing away, removing toxic substances, with short treating period, curative effect is fast, cure rate is high, control difficulty in relapse after healing the features such as, treatment cost is low.

Description

A kind of treat pharmaceutical composition of oral ulcer and preparation method thereof
Technical field
The present invention relates to a kind of medicine, specifically a kind of pharmaceutical composition for treating oral ulcer.
Background technology
Oral ulcer is commonly called as " aphtha ", is a kind of common ulcerative damages disease for betiding oral mucosa, is more common in On the inside of lip, the position such as tongue, tongue abdomen, cheek mucosa, vestibule ditch, soft palate, the mucosa at these positions lack keratinization layer or keratinization compared with Difference.Tongue ulcer refers to and betides tongue, the oral ulcer of tongue abdominal part position.Sharp ache when oral ulcer is shown effect, local causalgia are bright Aobvious, severe patient can also affect diet, speak, and cause very big inconvenience to daily life；Can concurrently halitosis, chronic pharyngitiss, constipation, head The General Symptomies such as bitterly, dizzy, nauseous, weak, irritated, heating, lymphadenectasis.Oral ulcer is many factors synthesis The result of effect, it include local wound, psychentonia, food, medicine, malnutrition, hormonal readiness change and vitamin C or Trace element deficiency.At present people be all mostly using external medication oral ulcer, but existing external used medicine takes effect Slowly, treatment time is long, easy recurrence, and this just brings inconvenience for the use of people, and patient receives deeply painful for this.
Content of the invention
It is an object of the invention to provide a kind of pharmaceutical composition for treating oral ulcer, to solve in above-mentioned background technology The problem of proposition.
For achieving the above object, the present invention provides following technical scheme：
A kind of pharmaceutical composition for treating oral ulcer, is made up of according to weight portion following raw material：Radix Scutellariae 2-5 parts, gold silver Flower 4-10 parts, YINQIAO 2-10 part, magnesium stearate 0.5-4 part, prednisone 0.2-1.5 parts, levamisole 2-6 parts, Folic Acid 1.5-3 Part, vitamin C 3-6 parts, metronidazole 1-4 parts, Mel 4-10 parts and chlorhexidine 2-6 parts.
As further scheme of the invention：Vitamin C adopts vitamin C C, vitamin C A, vitamin C B1, vitamin One or several the mixture of CB5 and vitamin C K, YINQIAO using crystallite YINQIAO, methyl YINQIAO and ethoxy YINQIAO Plant or several mixture.
As further scheme of the invention：Mel adopts natural juice Mel.
The preparation method of the pharmaceutical composition of the treatment oral ulcer, comprises the following steps that：
YINQIAO, prednisone, levamisole and metronidazole are put into ball milling 1-3 hours in ball mill, obtain first by step one Mixture；
Step 2, Radix Scutellariae, Flos Lonicerae, magnesium stearate and chlorhexidine is added in the deionized water of gross weight 3-8 times, stirring Machine with the rotating speed stirring 15-30 minutes of 90-150rpm, obtains the first mixed solution at normal temperatures；
Step 3, the first mixture is added in the first mixed solution and is stirred, and divides 3-5 equivalent to add while stirring Folic Acid, vitamin C and Mel, again with the rotating speed stirring 45-60 minutes of 240-360rpm after being added completely into, then carry out decompression compression It is the mastic of 1.20-1.30 to density, then is packed.
Compared with prior art, the invention has the beneficial effects as follows：Raw material sources of the present invention extensively, fit by preparation process is simple For large-scale industrial production；In the present invention, each component plays synergism, easy to use, play blood stasis dispelling, disappear routed, only The functions such as blood, pain relieving, heat clearing away, removing toxic substances, with short treating period, curative effect is fast, cure rate is high, control difficulty in relapse after healing the features such as, treatment Low cost.
Specific embodiment
The technical scheme of this patent is described in more detail with reference to specific embodiment.
Embodiment 1
A kind of pharmaceutical composition for treating oral ulcer, is made up of according to weight portion following raw material：2 parts of Radix Scutellariae, Flos Lonicerae 5 Part, 4 parts of YINQIAO, 0.5 part of magnesium stearate, 0.2 part of prednisone, 2 parts of levamisole, 1.5 parts of Folic Acid, 3 parts of vitamin C, metronidazole 1 2 parts of part, 4 parts of Mel and chlorhexidine.Mixture of the vitamin C using vitamin C C and vitamin C A, YINQIAO adopt crystallite YINQIAO.
The preparation method of the pharmaceutical composition of the treatment oral ulcer, comprises the following steps that：
Crystallite YINQIAO, prednisone, levamisole and metronidazole are put into ball milling 1.5 hours in ball mill, are obtained by step one First mixture；
Step 2, Radix Scutellariae, Flos Lonicerae, magnesium stearate and chlorhexidine is added in the deionized water of 5 times of gross weight, blender Stirred 18 minutes with the rotating speed of 100rpm at normal temperatures, obtain the first mixed solution；
Step 3, the first mixture is added in the first mixed solution and is stirred, and divides 4 equivalent to add leaf while stirring Acid, vitamin C and Mel, are stirred 48 minutes with the rotating speed of 270rpm after being added completely into again, then carry out decompression and be compressed to density be 1.22 mastic, then packed.
Embodiment 2
A kind of pharmaceutical composition for treating oral ulcer, is made up of according to weight portion following raw material：3 parts of Radix Scutellariae, Flos Lonicerae 7.5 parts, 6 parts of YINQIAO, 1.5 parts of magnesium stearate, 0.7 part of prednisone, 4 parts of levamisole, 2.1 parts of Folic Acid, 4.5 parts of vitamin C, first 3.5 parts of 2 parts of nitre azoles, 6 parts of Mel and chlorhexidine.Mel adopts natural juice Mel.
The preparation method of the pharmaceutical composition of the treatment oral ulcer, comprises the following steps that：
YINQIAO, prednisone, levamisole and metronidazole are put into ball milling 2 hours in ball mill by step one, are obtained first and are mixed Compound；
Step 2, Radix Scutellariae, Flos Lonicerae, magnesium stearate and chlorhexidine is added in the deionized water of 6 times of gross weight, blender Stirred 24 minutes with the rotating speed of 120rpm at normal temperatures, obtain the first mixed solution；
Step 3, the first mixture is added in the first mixed solution and is stirred, and divides 3 equivalent to add leaf while stirring Acid, vitamin C and natural juice Mel, are stirred 54 minutes with the rotating speed of 300rpm after being added completely into again, then carry out decompression be compressed to close The mastic for 1.26 is spent, then is packed.
Embodiment 3
A kind of pharmaceutical composition for treating oral ulcer, is made up of according to weight portion following raw material：4 parts of Radix Scutellariae, Flos Lonicerae 9 Part, 7 parts of YINQIAO, 3 parts of magnesium stearate, 1.2 parts of prednisone, 5 parts of levamisole, 2.5 parts of Folic Acid, 5 parts of vitamin C, metronidazole 3 5 parts of part, 8 parts of Mel and chlorhexidine.Mixture of the vitamin C using vitamin C B1 and vitamin C B5, YINQIAO is using methyl silver Stick up the mixture with ethoxy YINQIAO.Mel adopts natural juice Mel.
The preparation method of the pharmaceutical composition of the treatment oral ulcer, comprises the following steps that：
YINQIAO, prednisone, levamisole and metronidazole are put into ball milling 3 hours in ball mill by step one, are obtained first and are mixed Compound；
Step 2, Radix Scutellariae, Flos Lonicerae, magnesium stearate and chlorhexidine is added in the deionized water of 8 times of gross weight, blender Stirred 30 minutes with the rotating speed of 130rpm at normal temperatures, obtain the first mixed solution；
Step 3, the first mixture is added in the first mixed solution and is stirred, and divides 3 equivalent to add leaf while stirring Acid, vitamin C and natural juice Mel, are stirred 57 minutes with the rotating speed of 330rpm after being added completely into again, then carry out decompression be compressed to close The mastic for 1.28 is spent, then is packed.
Embodiment 4
A kind of pharmaceutical composition for treating oral ulcer, is made up of according to weight portion following raw material：5 parts of Radix Scutellariae, Flos Lonicerae 10 parts, 8 parts of YINQIAO, 4 parts of magnesium stearate, 1.5 parts of prednisone, 6 parts of levamisole, 3 parts of Folic Acid, 6 parts of vitamin C, metronidazole 3 6 parts of part, 9 parts of Mel and chlorhexidine.Vitamin C adopts vitamin C C, vitamin C A, vitamin C B1, vitamin C B5 and Wei Sheng The mixture of plain CK, mixture of the YINQIAO using crystallite YINQIAO, methyl YINQIAO and ethoxy YINQIAO.Mel adopts natural juice Mel.
The preparation method of the pharmaceutical composition of the treatment oral ulcer, comprises the following steps that：
YINQIAO, prednisone, levamisole and metronidazole are put into ball milling 2 hours in ball mill by step one, are obtained first and are mixed Compound；
Step 2, Radix Scutellariae, Flos Lonicerae, magnesium stearate and chlorhexidine is added in the deionized water of 5 times of gross weight, blender Stirred 25 minutes with the rotating speed of 150rpm at normal temperatures, obtain the first mixed solution；
Step 3, the first mixture is added in the first mixed solution and is stirred, and divides 4 equivalent to add leaf while stirring Acid, vitamin C and natural juice Mel, are stirred 54 minutes with the rotating speed of 360rpm after being added completely into again, then carry out decompression be compressed to close The mastic for 1.25 is spent, then is packed.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie In the case of spirit or essential attributes without departing substantially from the present invention, the present invention can be realized in other specific forms.Therefore, no matter From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power Profit is required rather than described above is limited, it is intended that all in the implication and scope of the equivalency of claim by falling Change is included in the present invention.
Moreover, it will be appreciated that although this specification is been described by according to embodiment, not each embodiment is only wrapped Contain an independent technical scheme, this narrating mode of description is only that those skilled in the art should for clarity Using description as an entirety, the technical scheme in each embodiment can also form those skilled in the art through appropriately combined Understandable other embodiment.

Claims (4)

1. a kind of pharmaceutical composition for treating oral ulcer, it is characterised in that be made up of according to weight portion following raw material：Radix Scutellariae 2- 5 parts, Flos Lonicerae 4-10 parts, YINQIAO 2-10 part, magnesium stearate 0.5-4 part, prednisone 0.2-1.5 parts, levamisole 2-6 parts, leaf Sour 1.5-3 parts, vitamin C 3-6 parts, metronidazole 1-4 parts, Mel 4-10 parts and chlorhexidine 2-6 parts.
2. the pharmaceutical composition for the treatment of oral ulcer according to claim 1, it is characterised in that the vitamin C is adopted One or several the mixture of vitamin C C, vitamin C A, vitamin C B1, vitamin C B5 and vitamin C K, YINQIAO are adopted One or several mixture with crystallite YINQIAO, methyl YINQIAO and ethoxy YINQIAO.
3. the pharmaceutical composition for the treatment of oral ulcer according to claim 1 and 2, it is characterised in that the Mel is adopted Natural juice Mel.
4. a kind of preparation method of the pharmaceutical composition of the treatment oral ulcer as described in claim 1-3 is arbitrary, its feature exist In comprising the following steps that：
YINQIAO, prednisone, levamisole and metronidazole are put into ball milling 1-3 hours in ball mill, obtain the first mixing by step one Thing；
Step 2, Radix Scutellariae, Flos Lonicerae, magnesium stearate and chlorhexidine are added in the deionized water of gross weight 3-8 times, and blender exists With the rotating speed stirring 15-30 minutes of 90-150rpm under room temperature, the first mixed solution is obtained；
Step 3, the first mixture is added in the first mixed solution and is stirred, and divides 3-5 equivalent to add leaf while stirring Acid, vitamin C and Mel, again with the rotating speed stirring 45-60 minutes of 240-360rpm after being added completely into, then carry out decompression and are compressed to Mastic of the density for 1.20-1.30, then packed.
CN201611252652.XA 2016-12-30 2016-12-30 A kind of treat pharmaceutical composition of oral ulcer and preparation method thereof Pending CN106491725A (en)

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CN201611252652.XA CN106491725A (en) 2016-12-30 2016-12-30 A kind of treat pharmaceutical composition of oral ulcer and preparation method thereof

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Application Number Priority Date Filing Date Title
CN201611252652.XA CN106491725A (en) 2016-12-30 2016-12-30 A kind of treat pharmaceutical composition of oral ulcer and preparation method thereof

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107898705A (en) * 2017-12-21 2018-04-13 滨州医学院附属医院 It is a kind of can pre- anti-caries and canker sore mouthwash and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107898705A (en) * 2017-12-21 2018-04-13 滨州医学院附属医院 It is a kind of can pre- anti-caries and canker sore mouthwash and preparation method thereof
CN107898705B (en) * 2017-12-21 2021-01-12 滨州医学院附属医院 A collutory for preventing dental caries and oral ulcer, and its preparation method

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