CN103656208A - Compound liniment for treating neurodermatitis - Google Patents

Abstract

The invention relates to a compound liniment for treating neurodermatitis, which is prepared from pure plants. The invention is characterized in that the liniment is prepared from selected Chinese medicinal herb essence components with reasonable compatibility by a special technique. The Chinese medicinal herb effective components directly contact the skin, and have the effects of clearing away heat and toxic material and nourishing the blood to expel wind through transdermal absorption and affected part stimulation; and the liniment is convenient to use and does not have any toxic or side effect. The liniment is suitable for neurodermatitis, chronic eczema, lichen planus and many other skin diseases caused by various psychic factors and local stimulation, and can perform the function of improving cutaneous pigmentation and coarse and dark skin.

Description

A kind of neurodermatitis compound recipe liniment for the treatment of

technical fieldthe present invention relates to a kind for the treatment of neurodermatitis compound recipe liniment of pure plant extract.The Chinese herbal medicine composition that it is characterized in that selected reasonable compatibility, the active ingredient of formula is Borax, the Pseudobulbus Bletillae (Rhizoma Bletillae), Semen sojae atricolor, large linum, Cortex Lycii, Herba Portulacae, Cortex Phellodendri, Semen Persicae, Flos Carthami, the Chinese herbal medicine effective ingredients in the present invention directly contacts skin, by Transdermal absorption and stimulation affected part, play heat-clearing and toxic substances removing, the effect of nourishing blood to expel wind, and easy to use, without any toxic and side effects.Be applicable to by various Nervous and Mental Factors, the caused neurodermatitis of local excitation, chronic eczema, lichen planus etc. dermatosis, can also play and improve cutaneous pigmentation, coarse low and deep effect.

background technologyneurodermatitis is a kind of skin function obstacle disease, has obvious skin lesion.Skin lesion mostly occurs at nape or its both sides, fossa cubitalis, popliteal nest, forearm, thigh, shank and lumbosacral region etc., and primary disease is its main symptom with violent pruritus.Motherland's traditional medicine is referred to as " psoriasis ", " neurodermatitis " etc., thinks that the cause of disease is mainly to bother due to mind, internal injury caused by excess of seven emotions, and interior raw heart-fire in addition rheumatism is accumulate skin, due to stagnation of meridian-QI.Redder from the beginning of erythra, pruritus is more acute, and because of heart governing blood and vessels, hyperactivity of heart-fire, lies prostrate in nutrient blood, produces heat in blood, blood hot air wind producing, and wind is contained dry, belongs to heat in blood wind-dryness.For a long time sick, skin lesion is plump, and unity and coherence in writing is big and heavy, is lichenization person, and this is because of prolonged illness blood trouble, and wind is contained dry, belongs to blood-deficiency and wind-dry.The conventional stable tranquilizer of modern medicine or antihistamine drug oral medication, medication need be through physician guidance, and easily develops immunity to drugs, and simultaneously general medicine all can produce negative effect in various degree to human body, especially liver, renal function is had to infringement in various degree.Therefore finding a kind of safe, effective, convenient and practical external used medicine prevention and this class disease for the treatment of, is current problem in the urgent need to address.The object of the invention is to overcome above-mentioned the deficiencies in the prior art, the liniment that provides a kind of pure plant essence to extract, can play the multiple effects that turn to the chronic dermatosis of feature with paroxysmal skin pruritus and skin lichen such as control neurodermatitis, chronic eczema, lichen planus.

summary of the inventionthe present invention relates to liniment of a kind of pure plant essence extraction and preparation method thereof.It is characterized in that refining and forming with multiple pure natural Chinese herbal medicine essence,, containing any chemical composition, do not pass through combination principle, through grinding, soak into, head decocts, decoct again, filter, centrifugal, blend, the techniques such as stirring are made, and have greatly improved the pharmacological action of Chinese herbal medicine, and human body is had no side effect, and there is heat-clearing and toxic substances removing, the effect of nourishing blood to expel wind.

The formula following (component and percentage by weight % thereof) that the present invention selects: Borax 15.0-20.0, Pseudobulbus Bletillae (Rhizoma Bletillae) 20.0-25.0, Semen sojae atricolor 15.0-20.0, large linum 10.0-15.0, Cortex Lycii 10.0-18.0 Herba Portulacae 10.0-25.0, Cortex Phellodendri 10.0-15.0, Semen Persicae 10.0-20.0, Flos Carthami 15.0-30.0.

Borax pharmacological action: 1, bacteriostasis: have report to point out, Borax is a weak base, the bacteriostasis that it is the same with boric acid a little less than having.By flat band method, make in culture medium the Borax containing 10%, escherichia coli, bacillus pyocyaneus, anthrax bacillus, shigella flexneri, shigella, Bacillus typhi, Salmonella paratyphi, Bacillus proteus and staphylococcus, Candida albicans are all had to inhibitory action; With paper disk method, prove, Borax can also suppress diphtheria corynebacterium, cattle type Brucella, Diplococcus pneumoniae, meningococcus and Hemolytic streptococcus etc.2, other effects: Borax still has effect anticorrosion and protection skin mucosa.Clinically can rinse ulcer, abscess by this product, particularly mucosa inflammation, as conjunctivitis, gastritis etc., because it is alkalescence, can make mucosa de-sludging, oral for urethra sterilization, particularly urine when acid, can make it to become alkalescence.

Pseudobulbus Bletillae (Rhizoma Bletillae) pharmacological action: 1, anastalsis: it is active that the Pseudobulbus Bletillae (Rhizoma Bletillae) can strengthen platelet factor III, significantly shortens clotting time and thrombinogen formation time, suppresses plasmin enzymatic activity, and local hemorrhage is had to anastalsis; Zoopery shows, external haemostatic effect is quite good to parenchymatous organ's (liver, spleen), muscle vascular be hemorrhage etc. for Pseudobulbus Bletillae (Rhizoma Bletillae) water extraction.2, antibacterial, antifungic action: the immersion of Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol has inhibitory action to staphylococcus aureus, bacillus subtilis, Bacillus tuberculosis; Water logging agent has inhibitory action to microsporon audouini; Contained 3 biphenyl classes and 2 the luxuriant and rich with fragrance compounds of two hydrogen of Pseudobulbus Bletillae (Rhizoma Bletillae) have inhibitory action to staphylococcus aureus, bacillus subtilis, Candida albicans and Trichophyton.

Semen sojae atricolor, nature and flavor are sweet, flat, nontoxic.Have invigorate blood circulation, diuretic, dispel the wind, the function of the strong blood of heat-clearing and toxic substances removing, nourishing, tonify deficiency black hair.In < < Compendium of Materia Medica > >, mention: it is many that Semen sojae atricolor enters kidney merit, therefore can harness the river, relieving distension, the therapeutic method to keep the adverse QI flowing downwards, wind heat processed and promoting blood circulation and detoxication.In Semen sojae atricolor, trace element is as all very high in the content of zinc, copper, magnesium, molybdenum, selenium, fluorine etc., and these trace element are extremely important to delaying human body caducity, reduction blood viscosity etc.Testa sojae atricolor is black, contains anthocyanidin, and anthocyanidin is good antioxidant source, can remove interior free yl, and especially, under the sour environment of stomach, antioxidant effect is good, and skin maintenance increases enterogastric peristalsis.

Large linum function cures mainly: nourishing blood to expel wind, moistening dryness for relaxing bowels.For skin pruritus, leprosy, dizzy, constipation.The about 30%-40% of the fatty oil of seed, in oil, main component is linoleic acid, linolenic acid, oleic acid, myristic acid, Palmic acid etc.

The pharmacological action of Cortex Lycii: 1, resisting pathogenic microbes effect: Cortex Lycii decoct has stronger inhibitory action to Bacillus typhi, paratyphoid bacillus A and bacterium flexneri, but to staphylococcus aureus without effect; To tubercule bacillus, it is poor efficiency antibacterial medicines.2, other effects: Cortex Lycii water decoction produces interleukin II to normal mouse boosting cell inhibitory action; Caused by cyclophosphamide mouse boosting cell interleukin II is produced and reduces the potentiation that is significantly increased; Interleukin II due to azathioprine is produced to the extraordinary inhibitory action that has.

Herba Portulacae pharmacological action: 1, bactericidal antiphlogistic: Herba Portulacae has stronger inhibitory action to dysentery bacterium, Bacillus typhi and escherichia coli, can be used for the auxiliary treatment of various inflammation, have the title of " natural antibiotics ".2, inducing diuresis to remove edema: the Herba Portulacae that reduces blood pressure contains a large amount of potassium salt, has good inducing diuresis to remove edema effect; Potassium ion also can directly act in blood vessel wall, makes blood vessel wall expansion, stops ductus arteriosus wall to thicken, thereby plays the effect reducing blood pressure.3, eliminate toxic dust: prevent and treat ulcer Herba Portulacae and can eliminate toxic dust, prevent phagocyte degeneration and necrosis, can also prevent lymphatic vessel inflammation and stop fibroid to change, stop silicon tuberosity and form, vitiligo is also had to certain curative effect; Herba Portulacae also contains more carotene, can promote the healing of Peptic Ulcers.

Cortex Phellodendri pharmacological action: 1, antibacterial action: Cortex Phellodendri antibiotic effective ingredient is berberine, thus its pharmacological action and Rhizoma Coptidis broadly similar, but content is low compared with Rhizoma Coptidis.In vitro tests to staphylococcus aureus, streptococcus pneumoniae, diphtheria corynebacterium, Streptococcus viridans, dysentery bacterium, Hemolytic streptococcus, meningococcus, vibrio cholera, anthrax bacillus all effectively or have a stronger inhibitory action.2, antifungic action: the ether extract of Cortex Phellodendri and Cortex Phellodendri has stronger bacteriostasis to Cryptococcus histolyticus and trichophyton purpureatum, its effect is stronger than nystatin, but a little less than the inhibitory action of Candida albicans is enjoyed than mildew making.3, the impact on immunologic function.Cortex Phellodendri decoct, 100% concentration, 0.3ml/ gavage, continuous 7 days, can increase mice spleen plaque forming cells number.

Semen Persicae pharmacological action: Semen Persicae extracting solution can obviously increase cerebral blood flow, the blood flow of increase dog femoral artery, reduces vascular resistance, improves hemodynamic situation.Extract can improve the liver surface microcirculation of animal, and promotes bile secretion.Semen Persicae can make the hemorrhage and clotting time of mice obviously extend, and decoct has inhibitory action to external thrombus, and decocting liquid has fiber facilitation.In Semen Persicae, contain 45% fatty oil Castor Oil intestinal, be beneficial to defecation.Semen Persicae can promote primipara's uterine contraction and hemorrhage.Water decoction and extract have analgesia, antiinflammatory, antibacterial, anti-allergic effects.

Flos Carthami pharmacological action: Flos Carthami polysaccharide is different from the polysaccharide that in higher plant, a-key connects, is similar to the polysaccharide of bacterial origin.From external pouring, turn experiment and show, Flos Carthami polysaccharide and the original synergism of T cell mitogenesis, to former the having no significant effect of B cell mitogenesis.But PFC test in body, Flos Carthami polysaccharide with it is generally acknowledged that to act on the astragalus polysaccharides effect trend of B cell consistent.Give the asynchronism(-nization) of injected in mice Flos Carthami polysaccharide, the variation of mice PFC value is also different: after sensitization, the PFC of administration group is promoted, and before sensitization, the PFC of administration group is anti-suppressed.Show that Flos Carthami polysaccharide has shown the amphicheirality of immune drug equally.Flos Carthami polysaccharide can obviously resist the immunosuppressive action of meticortelone, and the immunological enhancement that it suppresses mice to meticortelone is more obvious to the effect of normal mouse.Therefore, Flos Carthami polysaccharide can promote to drench cell transformation, increases the cell number of splenocyte to sheep red blood cell plaque test, and the immunosuppressive action of antagonism meticortelone etc., show that it is a kind of new, worth further immunomodulator of research.Also there is antiinflammatory, blood pressure lowering, fatigue-resisting function simultaneously.

The preparation method of product of the present invention is:

1) Borax, the Pseudobulbus Bletillae (Rhizoma Bletillae), Semen sojae atricolor, large linum, Cortex Lycii, Herba Portulacae, Cortex Phellodendri, Semen Persicae, Flos Carthami, through grinding, soaks one hour;

2), after big fire is heated to boiling, from boiling 30 minutes, leach the head liquid of boiling medicine;

3) add again clear water, continue slow fire and decoct, repeat 2) step 2 ~ 3 time; Leach the liquid of boiling medicine again;

4) Chinese herbal medicine fluid leaching is mixed, 2000 revs/min are carried out centrifugally, extract the medicinal liquid of supernatant;

5) cooling, take the dish out of the pot, subpackage, high temperature sterilize, the warehouse-in that is up to the standards is standby.

The present invention has the following advantages:

(1) refine pure natural plant Chinese herbal medicine elite composition, nontoxic to human body skin;

(2) screen the multiple heat-clearing and toxic substances removing that has, nourishing blood to expel wind effect natural vegetable Chinese herbal medicine elite composition, can effectively suppress developing of neurodermatitis, adheres to using, can improve pachylosis, low and deep, the dermatosiss such as control neurodermatitis be played to the effect of auxiliary treatment;

(3) externally applied liniment transdermal absorption factor is high, is difficult for developing immunity to drugs, and has avoided the infringement of medicinal liquid for oral administration to liver, renal function, adheres to using evident in efficacy to the disease-resistant health care of foot;

(4) its making, easy to use, safety, has no side effect;

(5) the experiment proved that, active ingredient is stable, and effect is lasting, long shelf-life.

the specific embodiment:the present invention is described in further detail in conjunction with the embodiments for face:

According to following table institute column data (percentage by weight %) and described step thereof, be configured:

Formula one:

Borax 15.0-20.0

Pseudobulbus Bletillae (Rhizoma Bletillae) 20.0-25.0

Semen sojae atricolor 15.0-20.0

Large linum 10.0-15.0

Cortex Lycii 10.0-18.0

Herba Portulacae 10.0-25.0

Cortex Phellodendri 10.0-15.0

Semen Persicae 10.0-20.0

Flos Carthami 15.0-28.0

Water to 100.0

Formula two:

Borax 18.0-20.0

Pseudobulbus Bletillae (Rhizoma Bletillae) 22.0-25.0

Semen sojae atricolor 18.0-20.0

Large linum 12.0-15.0

Cortex Lycii 12.0-18.0

Herba Portulacae 15.0-25.0

Cortex Phellodendri 12.0-15.0

Semen Persicae 15.0-20.0

Flos Carthami 16.0-25.0

Water to 100.0

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Formula three:

Borax 18.0-19.0

Pseudobulbus Bletillae (Rhizoma Bletillae) 22.0-23.5

Semen sojae atricolor 18.0-19.0

Large linum 12.0-13.5

Cortex Lycii 12.0-15.0

Herba Portulacae 15.0-20.0

Cortex Phellodendri 12.0-14.0

Semen Persicae 15.0-18.0

Flos Carthami 18.0-22.0

Water to 100.0

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Claims (2)

1. the present invention relates to a kind for the treatment of neurodermatitis compound recipe liniment of pure plant extract, it is characterized in that having following formula (component and percentage by weight % thereof): Borax 15.0-20.0, Pseudobulbus Bletillae (Rhizoma Bletillae) 20.0-25.0, Semen sojae atricolor 15.0-20.0, large linum 10.0-15.0, Cortex Lycii 10.0-18.0 Herba Portulacae 10.0-25.0, Cortex Phellodendri 10.0-15.0, Semen Persicae 10.0-20.0, Flos Carthami 15.0-30.0.

2. described in claim 1, treat a neurodermatitis compound recipe liniment, it is characterized in that having following technique:

1) Borax, the Pseudobulbus Bletillae (Rhizoma Bletillae), Semen sojae atricolor, large linum, Cortex Lycii, Herba Portulacae, Cortex Phellodendri, Semen Persicae, Flos Carthami, through grinding, soaks one hour;

2), after big fire is heated to boiling, from boiling 30 minutes, leach the head liquid of boiling medicine;

3) add again clear water, continue slow fire and decoct, repeat 2) step 2 ~ 3 time; Leach the liquid of boiling medicine again;

4) Chinese herbal medicine fluid leaching is mixed, 2000 revs/min are carried out centrifugally, extract the medicinal liquid of supernatant;

5) cooling, take the dish out of the pot, subpackage, high temperature sterilize, the warehouse-in that is up to the standards is standby.