CN104415144A - Snail burn spray - Google Patents
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- CN104415144A CN104415144A CN201310399756.3A CN201310399756A CN104415144A CN 104415144 A CN104415144 A CN 104415144A CN 201310399756 A CN201310399756 A CN 201310399756A CN 104415144 A CN104415144 A CN 104415144A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/20—Aceraceae (Maple family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention relates to a snail burn spray. The snail burn spray is prepared by taking a snail mucus extract as a main acting component for treating burns and being compatible with honeysuckle flower, root of delavay dobinea, acacia catechu, baical skullcap root, amur corktree bark, borneol, glycerine, ethanol and other raw materials; and according to different properties of the various traditional Chinese medicines, the raw materials are prepared into an ointment according to the proportion after different types of pretreatment, and the snail burn spray has good effects of sterilizing, relieving pain and promoting granulation, and is suitable for treating burns and other symptoms. The snail burn spray provided by the invention belongs to the technical field of clinical treatment of burns. The technical principle of the invention is that natural traditional Chinese medicines are selected, no chemical additives are added, and the effects and advantages of the medicines are used, thereby rapidly forming a 'protective film' on a wound, preventing bacteria and dust from intruding, effectively controlling the infection of the wound, being non-irritating to the wound, effectively promoting healing of the wound, obviously shortening the healing time of the wound, properly protecting residual epithelial tissues, accelerating the growth of epithelial cells and having an obvious analgesic effect; and a preparation process is simple, and the snail burn spray is convenient to use.
Description
technical fieldthe present invention relates to a kind of Limax SHAOSHANG PENWUJI, it is using Limax mucus extract as treatment burn Main Function composition, and the raw materials such as compatibility Flos Lonicerae, Radix Dobineae Delavayi, Catechu, Radix Scutellariae, Cortex Phellodendri, Borneolum Syntheticum, glycerol, ethanol, according to the different qualities of every taste Chinese medicine, after different pretreatments, be configured to unguentum in proportion, have effect of good sterilization, pain relieving, granulation promoting, be applicable to the symptoms such as treatment burn.The invention belongs to Burns treatment technology field.Know-why of the present invention selects natural Chinese medicine, do not add any chemical addition agent, utilizes the Action advantage of each medicine; form " protecting film " at wound surface rapidly, prevent antibacterial and dust from invading, effectively control traumatic infection; and to wound surface nonirritant; can wound healing effectively, obviously shorten wound healing time, the epithelial tissue that safekeeping is residual; and accelerate epithelial cell growth; analgesic effect is obvious, and preparation technology is simple, easy to use.
background technologyburn is also known as scald, and body directly contacts high temp objects or is subject to the change that strong heat radiation occurs.The degree of burn is by the height of temperature, the length of action time and different.The change of local can be divided into four degree.First degree: congested because of angioparalysis.Second degree: form the burn vesicle being full of serum.3rd degree: tissue necrosis.Fourth: the carbonization of tissue.Scar hyperplasia is serious sequela after burn patient wound healing, caused by the pathological change in the agglutination of wound surface own.According to statistics, in the wounded of scar hyperplasia, the age accounted for 70-80% below 30 years old; The people of coloured race and cicatrix body constitution, has the tendency that cicatrix hyperplasia occurs; Chemical burn, napalm burn, the serious cicatrix of normal generation; Burn darker (dark more than two degree wound surface), scar hyperplasia is more obvious; Traumatic infection often can increase chance and the order of severity of cicatrization; Scar contracture and hypertrophy can have a strong impact on the quality of life of patient.
Owing to it be unclear that the mechanism of cicatrization, therefore also do not prevent and treat the specific medicament of cicatrix at present, but early prevention there is certain effect to scar hyperplasia and contracture.Preventive measure mainly contains: deep wounds should prevent and infection control, as long as systemic conditions allows, carries out surgery skin grafting as early as possible; Wound surface, once healing, namely adheres to, with Elastic bandage or elastic sleeve pressurization, adhering to round the clock, can effectively reduce scar contracture and hypertrophy like this during use as early as possible; Carry out the dysfunction that functional exercise causes to alleviate scar contracture as early as possible.Namely many opinions carry out early functional exercise in burn treating process at present, if patient actively coordinates, often can obtain comparatively ideal therapeutic effect.
Limax mucus extract is containing natural collagen protein, elastin, allantoin, glucuronic acid, multivitamin etc.Skin deep layer is brought in nutrition contained by these compositions into, can repair skin, can increase the nutrition of skin; Allantoin can supplement the cell regeneration factor, can make skin rapid regeneration, and then recovers the softness, smooth, fine and smooth of skin, has therefore been applied in cosmetic formulations.Meanwhile, further study confirmation, Limax mucus extract is at Burn skin and the large scarred skin of process and have significant effect equally in the nursing of the problem skins such as pigmentation.The present invention adopts Limax mucus extract as treatment burn Main Function composition; and with multiple Chinese herbal medicine synergism; outer for after burn wound; form layer protecting film immediately; there is effect of sterilization, pain relieving, granulation promoting; the downright bad crust of burn or eschar can be made to liquefy rapidly disengaging, avoid the generation of burn wound sepsis.Effectively prevent burn infection, alleviate burn wound's pain, impel wound surface immediate union, prevent scar hyperplasia and pruritus.
summary of the inventionmain points of the present invention are to adopt Limax mucus extract, Flos Lonicerae, Radix Dobineae Delavayi, Catechu, Radix Scutellariae, Cortex Phellodendri, Borneolum Syntheticum, glycerol, ethanol etc. to form for main component uses modern technologies to be carefully dished up; outer for after burn wound; " protecting film " is formed rapidly at wound surface; prevent antibacterial and dust from invading; effectively control traumatic infection, and to wound surface nonirritant, can wound healing effectively.
The formula that the present invention selects following (component and percentage by weight % thereof): Limax mucus extract 5.0-8.0, Flos Lonicerae 3.0-5.0, Radix Dobineae Delavayi 1.0-3.0, Catechu 1.0-2.0, Radix Scutellariae 1.0-2.0, Cortex Phellodendri 1.0-2.0, Borneolum Syntheticum 0.1-1.0, glycerol 5.0-10.0, ethanol 60.0-70.0, water adds to 100.
Limax mucus refers to the mucus secreted in Limax crawling process, therefrom the elite thing of extracted by filtration, and we are just referred to as Limax mucus extract.Limax mucus extract makes the requisite material of cosmetics containing natural allantoin, calcium, glycolic acid, ossein, protein and vitamin etc.; Limax mucus extract or natural antibiotics, can kill some antibacterial on skin, and can eliminate skin speckle and acne; The chemical composition that Limax mucus extract contains has firming effect, can make skin rapid regeneration.The allantoin extracted from Limax mucus can make skin regeneration; Protein and vitamin can increase the nutrition of skin, make skin finer and smoother and smooth, have therefore been applied in cosmetic formulations.Meanwhile, further study confirmation, Limax mucus extract is at Burn skin and the large scarred skin of process and have significant effect equally in the nursing of the problem skins such as pigmentation.
Flos Lonicerae Flos Lonicerae is cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treat effect of wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.The diseases such as it is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.Flos Lonicerae tea has unique weight losing function simultaneously, can also suppress and the pathogen killing bottleneck throat, have infection effect to old man and child.So, often take Flos Lonicerae soak or decoct be conducive to wind-fire conjunctival congestion, laryngopharynx swelling and pain, obesity, the hypertensive treatment of liver-heat disease regulating liver-QI pattern of fever and rehabilitation.In addition, with Fructus Forsythiae, Flos Lonicerae soup decocted by Radix Isatidis can treat parotitis; Flos Lonicerae tea can drive away summer heat improving eyesight; The cool soup of Fructus Forsythiae Flos Lonicerae can treat fever caused by exogenous pathogens cough.Flos Lonicerae, Flos Chrysanthemi, Radix Platycodonis and Radix Glycyrrhizae are added water boil 10 minutes, Hou Liang simultaneously, when beverage is drunk, pharyngolaryngitis and tonsillitis can be treated.
Radix Dobineae Delavayi is the rhizome of Anacardiaceae plant Dobinea delavayi.In the careless slope being on the sunny side born in height above sea level 1100-2300m or shrubbery.Be distributed in the ground such as Sichuan, Yunnan.Property mildly bitter flavor; Cool, GUIXIN; Lung meridian.There is heat-clearing and toxic substances removing; Cough-relieving; Effect of pain relieving.Cure mainly cough due to lung-heat; Mastitis; Rib adenitis; Carbuncle furuncle furuncle; Traumatic injury.
Catechu, another name CATECHU, catechu, gambier are pulse family albizzia plant catechu tree, odorless, puckery, bitter first ,sweet later.Containing catechutannic acid 20 ~ 50%, cachou extract 2 ~ 20% and epicatechol, phlegmatic temperament, fatty oil, natural gum and wax etc.Catechu aqueous solution can suppress the wriggling of duodenum in rabbit and small intestinal, and can promote the retrostalsis of caecum, and has anti-diarrhea effect; But large intestine is not almost acted on.Catechu has in vitro and stronger kills ascites cells effect.Catechu decoct all has inhibitory action to staphylococcus aureus, diphtheria corynebacterium, Bacillus proteus, shigella flexneri and Bacillus typhi; Also inhibitory action is had for common therapeutic dermatophytes.The extract of its leaf all has inhibitory action to staphylococcus aureus, escherichia coli.For heat clearing away, promote the production of body fluid, stop blooding, cure mainly cough due to lung-heat, spitting of blood, diarrhoea, infantile dyspepsia; External is controlled skin infection and is not regained for a long time, skin eczema, aphtha, tonsillitis.
Radix Scutellariae another name Radix Scutellariae, tsuchikane tea root.For labiate Radix Scutellariae (Scutellaria baicalensis Georgi), be used as medicine with root.Have heat clearing and damp drying, removing heat from blood is antiabortive, detoxicating functions.Modern study proves, Radix Scutellariae mainly contains baicalin, baicalin, wogonin, the compositions such as wogonoside, neobaicalein, cupreol.Its antimicrobial spectrum is comparatively wide, has inhibitory action to various bacteria, dermatophytes, leptospira etc.Even if to the staphylococcus aureus that the antibiotic such as penicillin develop immunity to drugs, still very sensitive to Radix Scutellariae.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs.The effects such as Radix Scutellariae also has blood pressure lowering, calmness, diuresis, protects the liver, function of gallbladder promoting, antiallergic, releasing smooth muscle spasm.Use scutellaria for treating children with acute respiratory infection, infectious hepatitis, chronic tracheitis, acute bacillary dysentery, pyelonephritis etc. clinically, all can obtain good effect.Radix Scutellariae is also usually used in treating gynecological disorders, and Yuan Dynasty's well-known doctor's ZHU Dan-xi claims it to be " antiabortive panacea ".
Cortex Phellodendri is the dry bark of rutaceae wampee or Cortex Phellodendri.Hardship, cold.Return kidney, bladder, large intestine channel.Modern study shows, Cortex Phellodendri is containing the main component such as berberine, obacunone, in vitro tests to staphylococcus aureus, streptococcus pneumoniae, diphtheria corynebacterium, Streptococcus viridans, dysentery bacterium (except Song Nei Shi), Hemolytic streptococcus, meningococcus, vibrio cholera, anthrax bacillus all effectively or have stronger inhibitory action, therefore have antibacterial, convergence, antiinflammatory effect, to symptoms such as various skin noxious dampness, skin infection, effect is good.
Borneolum Syntheticum, has another name called sheet brain, Fructus Citri tangerinae sheet, Borneolum Syntheticum, MEIHUA BINGPIAN, Dipterocarpus pilosus, Flos Mume brain, Borneolum Syntheticum brain, Mei Bing etc., and being that resin and the volatile oil processed goods of Spore density Borneolum Syntheticum extracts the crystallization obtained, is near pure dextro Borneolum Syntheticum.Also have and chemically synthesize.Borneolum Syntheticum acrid in the mouth, hardship, be slightly cold; GUIXIN, liver, lung meridian; A surname is loose for delicate fragrance, has refreshment of having one's ideas straightened out, the loose poison of heat clearing away, effect of improving acuity of vision and removing nebula, and it can be used for for excess syndrome of stroke coma, for conjunctival congestion and swelling pain, sore throat aphtha, swells and ache for skin infection, does not hold back after bursting.
The preparation method of product of the present invention is:
(1) Limax mucus extract, Flos Lonicerae, Radix Dobineae Delavayi, Catechu, Radix Scutellariae, Cortex Phellodendri are mixed in proportion, and put into 90% ethanol and soak one month;
(2) appropriate Borneolum Syntheticum is weighed, and with 90% dissolve with ethanol Borneolum Syntheticum;
(3) Borneolum Syntheticum after dissolving is converted into the liquid, and mix homogeneously;
(4) glycerol is added in proportion, mix homogeneously;
(5) add suitable quantity of water, regulate concentration of alcohol in medicinal liquid to be 60-70%;
(6) sample immediately, after the assay was approved, subpackage, labeling, sealing.
The present invention has the following advantages:
(1) select natural Chinese medicine, do not add any chemical addition agent, not containing any hormone, have no side effect;
(2) form " protecting film " at wound surface rapidly, prevent antibacterial and dust from invading, effectively control traumatic infection;
(3) to wound surface nonirritant, can wound healing effectively, obviously shorten wound healing time;
(4) epithelial tissue that safekeeping is residual, and accelerate epithelial cell growth, analgesic effect is obvious;
(5) few, the good stability of use amount, technique is simple;
(6) there is good compliance, be applicable to the symptoms such as treatment burn.
detailed description of the inventionbelow in conjunction with embodiment, the present invention is described in further detail:
Be configured according to data listed in Table (percentage by weight %) and described step thereof:
Formula one:
Limax mucus extract 5.0-6.0, Flos Lonicerae 3.0-4.0, Radix Dobineae Delavayi 1.0-2.0, Catechu 1.5-2.0, Radix Scutellariae 1.5-2.0, Cortex Phellodendri 1.0-2.0, Borneolum Syntheticum 0.1-1.0, glycerol 5.0-8.0, ethanol 65.0-70.0, water adds to 100.
Formula two:
Limax mucus extract 7.0-8.0, Flos Lonicerae 4.0-5.0, Radix Dobineae Delavayi 2.0-3.0, Catechu 1.0-1.5, Radix Scutellariae 1.0-1.5, Cortex Phellodendri 1.0-2.0, Borneolum Syntheticum 0.1-1.0, glycerol 8.0-10.0, ethanol 60.0-65.0, water adds to 100.
Formula three:
Limax mucus extract 6.0-7.0, Flos Lonicerae 3.0-4.0, Radix Dobineae Delavayi 1.0-2.0, Catechu 1.0-1.5, Radix Scutellariae 1.0-2.0, Cortex Phellodendri 1.0-1.5, Borneolum Syntheticum 0.1-1.0, glycerol 5.0-8.0, ethanol 63.0-68.0, water adds to 100.
Claims (2)
1. the present invention relates to a kind of Limax SHAOSHANG PENWUJI, it is characterized in that there is following formula (component and percentage by weight % thereof): Limax mucus extract 5.0-8.0, Flos Lonicerae 3.0-5.0, Radix Dobineae Delavayi 1.0-3.0, Catechu 1.0-2.0, Radix Scutellariae 1.0-2.0, Cortex Phellodendri 1.0-2.0, Borneolum Syntheticum 0.1-1.0, glycerol 5.0-10.0, ethanol 60.0-70.0, water adds to 100.
2. Limax SHAOSHANG PENWUJI according to claim 1, is characterized in that having following preparation technology:
(1) Limax mucus extract, Flos Lonicerae, Radix Dobineae Delavayi, Catechu, Radix Scutellariae, Cortex Phellodendri are mixed in proportion, and put into 90% ethanol and soak one month;
(2) appropriate Borneolum Syntheticum is weighed, and with 90% dissolve with ethanol Borneolum Syntheticum;
(3) Borneolum Syntheticum after dissolving is converted into the liquid, and mix homogeneously;
(4) glycerol is added in proportion, mix homogeneously;
(5) add suitable quantity of water, regulate concentration of alcohol in medicinal liquid to be 60-70%;
(6) sample immediately, after the assay was approved, subpackage, labeling, sealing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310399756.3A CN104415144A (en) | 2013-09-06 | 2013-09-06 | Snail burn spray |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310399756.3A CN104415144A (en) | 2013-09-06 | 2013-09-06 | Snail burn spray |
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| CN104415144A true CN104415144A (en) | 2015-03-18 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107281303A (en) * | 2017-08-22 | 2017-10-24 | 马鞍山中粮生物化学有限公司 | A kind of nontoxic SHAOSHANG PENWUJI and its preparing process |
| JP2020045338A (en) * | 2018-09-12 | 2020-03-26 | 大正製薬株式会社 | External composition |
-
2013
- 2013-09-06 CN CN201310399756.3A patent/CN104415144A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107281303A (en) * | 2017-08-22 | 2017-10-24 | 马鞍山中粮生物化学有限公司 | A kind of nontoxic SHAOSHANG PENWUJI and its preparing process |
| JP2020045338A (en) * | 2018-09-12 | 2020-03-26 | 大正製薬株式会社 | External composition |
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Application publication date: 20150318 |