CN103705871A - Traditional Chinese medicine preparation for treating periodontitis - Google Patents

Abstract

The invention provides a traditional Chinese medicine preparation for treating periodontitis. The traditional Chinese medicine preparation is prepared from the following raw materials: drynaria rhizome, fructus viticis, rhizoma anemarrhenae, moutan bark, houttuynia cordata, caulis spatholobi, eclipta, radix scrophulariae, the seed of Chinese dodder, rhizoma polygonati, root of common peony, rheum officinale, polygonum cuspidatum, changium smyrnioides, licorice root, fraxinus bungeana, ixora chinensis, cassia twig, radix curcumae longae, selaginella tamariscina, parasitic loranthus, morinda officinalis, cryptotaenia japonica, bauhinia championii, honeysuckle stem, dogwood, cortex acanthopanacis, alpine yarrow herb, isodon amethystoides, aster ageratoides, cistanche, cimicifugae foetidae and panax japonicus. The traditional Chinese medicine preparation is stable in action and small in side effect, and can be used for effectively relieving the symptom of the periodontitis so as to improve the living quality of a patient. In addition, the traditional Chinese medicine preparation cannot perform toxic and side effects.

Description

The Chinese medicine preparation that is used for the treatment of periodontitis

Technical field

The present invention relates to Chinese medicine technical field, relate in particular to a kind of Chinese medicine preparation that is used for the treatment of periodontitis.

Background technology

Periodontal disease is one of oral cavity common disease, also be the main cause that causes oral cavity mistake tooth, it refers to the destructive disease of the chronic progressive external occurring on tooth supporting tissue, the main manifestations of periodontitis part is that tooth is followed red and swollen hemorrhage, periodontal pocket formation, pyorrhea, frontal resorption and odontoseisis, finally causes loss of tooth.Modern medicine viewpoint is thought, periodontal disease is mainly that the dynamic equilibrium maintaining between bacteria attack and host defense is broken caused chronic infectious disease, from part, antibacterial and bacterial plaque are the initiation factors that causes periodontal disease, simultaneously systemic factor reduces host's defence and repair ability as endocrine disturbance, immunodeficiency or changing function, thereby contributes to generation or the development of disease.Because being one, most of periodontal disease take local factor as main, the disease that has again systemic factor to participate in, and at present its treatment mainly be take to part as main, and less to whole body fuselage state adjustment consideration, cause and be sometimes difficult to obtain satisfied clinical therapeutic efficacy.

For periodontitis treatment, the conventional method of using mechanical removal bacterial plaque and tartar of doctor trained in Western medicine, comprise scaling, scrape control, root planing (Scalingandrootplaning, SRP) etc., be treatment periodontitis, prevent the topmost, simple of its recurrence and effective means.Meanwhile, coordinate Drug therapy.The Drug therapy of periodontitis comprises systemic drug treatment and topical medications, systemic drug treatment Common Antibiotics, as nitro miaow class medicine, first nitre sound of crying or vomiting, for nitre; Local application mainly contains rinsing the mouth medicine, local antiinflammatory astringency, antibacterials flushing, slow release and the controlled release local antibacterial medicine of being coated with.But above Therapeutic Method is Shortcomings part also, on the one hand, conventional therapy comprises that ultrasound wave is caught up with under scaling, dental caries and scrapes and control, sometimes therapeutic response is not good, or the scaling repeatedly of some position, scrape control after still poor effect even recur, on the other hand, antibacterials or part antibacterials for whole body, the concentration that medicine arrives periodontal part is lower; Long-term efficacy is undesirable, and side effect is more, should not take for a long time, and the Drug resistance of pathogenic microorganism constantly strengthens in recent years in addition, and antibiotic curative effect reduces day by day, and heavy dose of long-time use easily causes dysbacteriosis, and inducible resistance bacterial strain produces; Easily produce systemic anaphylaxis, gastrointestinal side effect etc., in the time of eliminating bacteria, proposed again in recent years to regulate the Therapeutic Method of host defense function, block some bioactive substances that host produces.But majority is zooscopy, or the clinical evidence that lacks large sample amount confirms its effectiveness and safety.

Theory of Chinese medical science think that periodontitis is mainly kidney qi virtual loss, stomach-fire is red-hot or insufficiency of vital energy and blood due to.Kidney governing bones, She that tooth is bone, tooth is supplemented nutrition by kidney qi, stomach channel of foot-Yang-ming per nasal enters upper gums outward, and the large intesting channel of Hand-Yangming enters lower gums through cervical region to buccal, and gingiva is closely related with gastrointestinal function, once there is stomach-QI being unable to descend normally, intestinal is lost leads, and on foul smell and dampness, smokes in mouth, itself has made odontopathy and periodontal disease easily send out, the reason that has again exopathogen six climate exopathogens, interior evil seven emotions and wound to pollute, positive exogenous pathogen enters, and whole body is combined with Local Phase, thereby finally causes periodontal disease.

The treatment of the traditional Chinese medical science is often conceived to whole regulating action, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, and " strengthening the body resistance " focuses on contacting of local and whole body, payes attention to the disease-resistant potential of performance human body.There is good therapeutic effect improving aspect tcm syndrome.Treatment by Chinese herbs effect is steady, side effect is little, can effectively improve symptom, improves patient's quality of life, adopts Chinese medicine periodontitis curative effect progressively to be affirmed, not find the side effect.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of Chinese medicine preparation that is used for the treatment of periodontitis, and its therapeutical effect is steady, side effect is little, can effectively improve symptom, improves patient's quality of life, has no side effect.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation that is used for the treatment of periodontitis, its crude drug comprises Rhizoma Drynariae, Fructus Viticis, the Rhizoma Anemarrhenae, Cortex Moutan, Herba Houttuyniae, Caulis Spatholobi, Herba Ecliptae, Radix Scrophulariae, Semen Cuscutae, Rhizoma Polygonati, Radix Paeoniae Rubra, Radix Et Rhizoma Rhei, Rhizoma Polygoni Cuspidati, Radix Changii, Radix Glycyrrhizae, Radix Gentianae Macrophyllae, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), Ramulus Cinnamomi, Rhizoma Curcumae Longae, Herba Selaginellae, Herba Taxilli, Radix Morindae Officinalis, Caulis et folium cryptotaeniae japonicae, Caulis Bauhihiae Championii, Caulis Lonicerae, Fructus Corni, Cortex Acanthopancis, achillea millefolium, Herba Rabdosiae glaucocalycis, Herba Asteris Ageratoidis, Herba Cistanches, Rhizoma Cimicifugae and Rhizoma Panacis Japonici.

Wherein, in described Chinese medicine preparation, the weight of each crude drug is respectively Rhizoma Drynariae 53g～63g, Fructus Viticis 20g～30g, Rhizoma Anemarrhenae 32g～42g, Cortex Moutan 27g～37g, Herba Houttuyniae 31g～41g, Caulis Spatholobi 39g～49g, Herba Ecliptae 35g～45g, Radix Scrophulariae 29g～39g, Semen Cuscutae 34g～44g, Rhizoma Polygonati 52g～62g, Radix Paeoniae Rubra 29g～39g, Radix Et Rhizoma Rhei 31g～41g, Rhizoma Polygoni Cuspidati 33g～43g, Radix Changii 26g～36g, Radix Glycyrrhizae 21g～31g, Radix Gentianae Macrophyllae 16g～26g, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 22g～32g, Ramulus Cinnamomi 17g～27g, Rhizoma Curcumae Longae 29g～39g, Herba Selaginellae 36g～46g, Herba Taxilli 27g～37g, Radix Morindae Officinalis 25g～35g, Caulis et folium cryptotaeniae japonicae 33g～43g, Caulis Bauhihiae Championii 22g～32g, Caulis Lonicerae 29g～39g, Fructus Corni 23g～33g, Cortex Acanthopancis 41g～51g, achillea millefolium 22g～32g, Herba Rabdosiae glaucocalycis 27g～37g, Herba Asteris Ageratoidis 19g～29g, Herba Cistanches 35g～45g, Rhizoma Cimicifugae 27g～37g and Rhizoma Panacis Japonici 36g～46g.

Wherein, in described Chinese medicine preparation, the weight of each crude drug is respectively Rhizoma Drynariae 56g～60g, Fructus Viticis 23g～27g, Rhizoma Anemarrhenae 35g～39g, Cortex Moutan 30g～34g, Herba Houttuyniae 34g～38g, Caulis Spatholobi 42g～46g, Herba Ecliptae 38g～42g, Radix Scrophulariae 32g～36g, Semen Cuscutae 37g～41g, Rhizoma Polygonati 55g～59g, Radix Paeoniae Rubra 32g～36g, Radix Et Rhizoma Rhei 34g～38g, Rhizoma Polygoni Cuspidati 36g～40g, Radix Changii 29g～33g, Radix Glycyrrhizae 24g～28g, Radix Gentianae Macrophyllae 19g～23g, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 25g～29g, Ramulus Cinnamomi 20g～24g, Rhizoma Curcumae Longae 32g～36g, Herba Selaginellae 39g～43g, Herba Taxilli 30g～34g, Radix Morindae Officinalis 28g～32g, Caulis et folium cryptotaeniae japonicae 36g～40g, Caulis Bauhihiae Championii 25g～29g, Caulis Lonicerae 32g～36g, Fructus Corni 26g～30g, Cortex Acanthopancis 44g～48g, achillea millefolium 25g～29g, Herba Rabdosiae glaucocalycis 30g～34g, Herba Asteris Ageratoidis 22g～26g, Herba Cistanches 38g～42g, Rhizoma Cimicifugae 30g～34g and Rhizoma Panacis Japonici 39g～43g.

Wherein, in described Chinese medicine preparation, the weight of each crude drug is respectively Rhizoma Drynariae 58g, Fructus Viticis 25g, Rhizoma Anemarrhenae 37g, Cortex Moutan 32g, Herba Houttuyniae 36g, Caulis Spatholobi 44g, Herba Ecliptae 40g, Radix Scrophulariae 34g, Semen Cuscutae 39g, Rhizoma Polygonati 57g, Radix Paeoniae Rubra 34g, Radix Et Rhizoma Rhei 36g, Rhizoma Polygoni Cuspidati 38g, Radix Changii 31g, Radix Glycyrrhizae 26g, Radix Gentianae Macrophyllae 21, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 27g, Ramulus Cinnamomi 22g, Rhizoma Curcumae Longae 34g, Herba Selaginellae 41g, Herba Taxilli 32g, Radix Morindae Officinalis 30g, Caulis et folium cryptotaeniae japonicae 38g, Caulis Bauhihiae Championii 27g, Caulis Lonicerae 34g, Fructus Corni 28g, Cortex Acanthopancis 46g, achillea millefolium 27g, Herba Rabdosiae glaucocalycis 32g, Herba Asteris Ageratoidis 24g, Herba Cistanches 40g, Rhizoma Cimicifugae 32g and Rhizoma Panacis Japonici 41g.

Wherein, the dosage form of described Chinese medicine preparation is powder and oral liquid.

Wherein, the powder that described Chinese medicine preparation is prepared into adopts mode for oral administration, every day 3 times, each 100g.

The present invention also provides the preparation method of above-mentioned Chinese medicine preparation, when powder that described Chinese medicine preparation is prepared into, is specially:

The first step, Rhizoma Drynariae, Cortex Moutan, Caulis Spatholobi, Herba Ecliptae, Radix Scrophulariae, Semen Cuscutae, Rhizoma Polygonati, Radix Paeoniae Rubra, Radix Morindae Officinalis, Fructus Corni, Cortex Acanthopancis, Herba Cistanches and Rhizoma Panacis Japonici are pulverized respectively, mix by weight, obtain mixture, in the ethanol that to add with respect to 4～6 times of determining alcohols of mixture quality be 70%～80%, flood 24 hours～36 hours, adopt percolation with the speed of 2～4ml per minute percolation slowly, collect percolate, percolate concentrating under reduced pressure, obtain and get dry extract, be ground into powder;

Second step, pulverizes component under She respectively, mixes by weight, add in cold water and soak 3 hours～5 hours, with slow fire boiling 2 hours～3 hours, the quality of the cold water adding was 2～4 times of the mixture quality that obtains of the first step, decoction liquor is filtered, and filtering residue was put into cold water again, with slow fire boiling 1 hour～2 hours, the quality of the cold water adding is 1～2 times of the mixture quality that obtains of the first step, merge filtrate, concentrating under reduced pressure, except anhydrating, obtain and get dry extract, be ground into powder;

The 3rd step, the powder of the first step and second step acquisition is mixed, and with respect to the protein sugar of 0.01～0.05 times of its quality, the dextrin of 0.1～0.2 times, the starch of 1～2 times is put into blender and is stirred 30 minutes～1 hour, make powder, with racking machine subpackage.

The present invention also provides the preparation method of above-mentioned Chinese medicine preparation, when oral liquid that described Chinese medicine preparation is prepared into, is specially:

The first step, Rhizoma Drynariae, Cortex Moutan, Caulis Spatholobi, Herba Ecliptae, Radix Scrophulariae, Semen Cuscutae, Rhizoma Polygonati, Radix Paeoniae Rubra, Radix Morindae Officinalis, Fructus Corni, Cortex Acanthopancis, Herba Cistanches and Rhizoma Panacis Japonici are pulverized respectively, mix by weight, obtain mixture, in the ethanol that to add with respect to 4～6 times of determining alcohols of mixture quality be 70%～80%, flood 24 hours～36 hours, adopt percolation with the speed of 2～4ml per minute percolation slowly, collect percolate, percolate concentrating under reduced pressure, obtain and get dry extract, be ground into powder;

Second step, pulverizes component under She respectively, mixes by weight, add in cold water and soak 3 hours～5 hours, with slow fire boiling 2 hours～3 hours, the quality of the cold water adding was 2～4 times of the mixture quality that obtains of the first step, decoction liquor is filtered, and filtering residue was put into cold water again, with slow fire boiling 1 hour～2 hours, the quality of the cold water adding is 1～2 times of the mixture quality that obtains of the first step, merge filtrate, concentrating under reduced pressure, except anhydrating, obtain and get dry extract, be ground into powder;

The 3rd step, mixes the powder of the first step and second step acquisition, adds the distilled water with respect to 3～5 times of amounts of powder quality, the sucrose of 0.1～0.3 times, and the sodium benzoate of 0.01～0.02 times, stirs, and boils, cooling, filter, subpackage, sterilizing obtains oral liquid.

The present invention also provides a kind of Chinese powder medicine that is used for the treatment of periodontitis, and its crude drug comprises Rhizoma Drynariae, Fructus Viticis, the Rhizoma Anemarrhenae, Cortex Moutan, Herba Houttuyniae, Caulis Spatholobi, Herba Ecliptae, Radix Scrophulariae, Semen Cuscutae, Rhizoma Polygonati, Radix Paeoniae Rubra, Radix Et Rhizoma Rhei, Rhizoma Polygoni Cuspidati, Radix Changii, Radix Glycyrrhizae, Radix Gentianae Macrophyllae, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), Ramulus Cinnamomi, Rhizoma Curcumae Longae, Herba Selaginellae, Herba Taxilli, Radix Morindae Officinalis, Caulis et folium cryptotaeniae japonicae, Caulis Bauhihiae Championii, Caulis Lonicerae, Fructus Corni, Cortex Acanthopancis, achillea millefolium, Herba Rabdosiae glaucocalycis, Herba Asteris Ageratoidis, Herba Cistanches, Rhizoma Cimicifugae and Rhizoma Panacis Japonici.

The present invention also provides a kind of Chinese medicine oral liquid that is used for the treatment of periodontitis, and its crude drug comprises Rhizoma Drynariae, Fructus Viticis, the Rhizoma Anemarrhenae, Cortex Moutan, Herba Houttuyniae, Caulis Spatholobi, Herba Ecliptae, Radix Scrophulariae, Semen Cuscutae, Rhizoma Polygonati, Radix Paeoniae Rubra, Radix Et Rhizoma Rhei, Rhizoma Polygoni Cuspidati, Radix Changii, Radix Glycyrrhizae, Radix Gentianae Macrophyllae, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), Ramulus Cinnamomi, Rhizoma Curcumae Longae, Herba Selaginellae, Herba Taxilli, Radix Morindae Officinalis, Caulis et folium cryptotaeniae japonicae, Caulis Bauhihiae Championii, Caulis Lonicerae, Fructus Corni, Cortex Acanthopancis, achillea millefolium, Herba Rabdosiae glaucocalycis, Herba Asteris Ageratoidis, Herba Cistanches, Rhizoma Cimicifugae and Rhizoma Panacis Japonici.

Beneficial effect of the present invention:

Chinese medicine preparation therapeutical effect provided by the invention is steady, side effect is little, can effectively improve symptom, improves patient's quality of life, has no side effect.

The specific embodiment

Periodontitis belongs to the categories such as the traditional Chinese medical science " gingival atrophy ", " tooth maggot ", " teeth shake ", " wind skin ulcer ", " food bed ".Motherland's medical science, by determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, thinks that the Etiological of gingival atrophy is roughly as follows: one, the pungent delicious food savoury of vegetarian diet, and eating and drinking without temperance, disorder of the spleen and stomach caused by internal damage, intrinsic heat fire-transformation, its heat is followed through upper steaming tooth and is made.Said as the bright doctor's pragma of < < > >: " the intestines and stomach is hindered in good wine; savoury, fat meat and fine grain, sweet greasy thing; so that attack on damp and hot, dental bed unclear and for swelling, be pain or hemorrhage or infested.By being that tooth can not be pacified and be shaken, black rotten de-also, common people's opinion of all suffering from a deficiency of the kidney is controlled.Hardly realize that this belongs to Yangming Channel damp and hot.Though tooth belongs to kidney and is born in dental bed, upper mandible belongs to positive bright large intestine and gastrointestinal.Stomach is hindered in the thing of good wine, savoury, fat meat and fine grain, sweet cunning, so that attacks on damp and hot, and dental bed is unclear and for swelling as pain, or hemorrhage, or infested, by being that tooth can not be pacified and shaken black rotten coming off also ".As < < surgery pandect > > points out: " gingival atrophy meaning spleen pathogenic heat in the stomach gushes and Xuan Luye ".And for example < < treatise on blood trouble tooth sail > > says: " dental bed particularly stomach through venation institute around, therefore all maggot blood is all flaming up of stomach-fire, blood is moving with fire, method for the treatment of be take cleaning stomach-fire as main ".

Two, deficiency of the kidney, hyperactivity of fire caused by deficiency of YIN, hyperactivity of deficient fire.Wang Bing says: " kidney master is in bone, and tooth is bone She, and kidney qi both declined, and essence nothing is supported, therefore make trichomadesis, tooth is withered again." Shen Jinao says: " tooth person, the mark of kidney, the basis of bone are also.Tooth is again brothers' Yangming Channel institute mistake, and upper tooth is subordinate to female soil, stomach of foot Yang Ming arteries and veins pass through network also～... lower tooth belongs to the bright large intestine venation of hands sun also." Ming Dynasty Zhang Jiebin points out in < < Jing Yue's complete work > >: " the institute end that lid tooth is bone, and kidney master in bone also, therefore say tooth and gap of renal failure, the solid tooth of essence is hard, to it, it is disease, all teeth are crisp not hard, or be easy to shake, or dredge open-minded, or prominent and unreal ... allly can't help worm and can't help fire and toothache person, must deficiency of kidney-QI, this or by congenital examining lose or by the day after tomorrow with funeral, all can cause it, be when take special the kidney invigorating gas as main.”

Three, insufficiency of vital energy and blood: plain body is weak, or prolonged illness consumption wound, insufficiency of vital energy and blood, can not go up semen deposition micro-in heel, and tooth is due to meat loses and supports.Kidney qi in life people declines by containing, ' deficiency of the kidney yin hyperactivity of deficient fire, causes hyperactivity of fire caused by deficiency of YIN, thereby occurs that neuroendocrine-immune network regulatory function is low; Gastrointestinal function by by force to a little less than, stomach-QI being unable to descend normally, intestinal is lost leads, foul smell and damp and hot on smoke, itself made odontopathy and periodontitis easily send out, then had the reasons such as exopathogen six climate exopathogens, interior evil seven emotions and wound, pollution, positive exogenous pathogen enters, whole body is combined with local factor, thereby finally causes the generation of periodontitis.Tooth is led by kidney, and upper mandible belongs to negative and positive large intestine stomach function regulating warp, and tooth and heel all need moistening of vim and vigour foster, therefore primary disease can be caused by factors such as steaming, vital essence virtual loss, insufficiency of vital energy and bloods in stomach-fire.Stomach internal organs accumulated heat, positive naked light is vehement, damp and hot fumigating in upper and form gingival atrophy; Kidney unit is deficient, kidney governing bones, She that tooth is bone, deficiency of the kidney, can not on reach, tooth loses and to moisten fosterly, causes odontoseisis, tooth is with atrophy; Deficiency of qi and blood, dental caries lose to be supported, pathogenic factor invasion, visitor between cog, cause tooth spawn blood, atrophy, root of the tooth appear, loosening.

It is Therapeutic Principle that heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, nourishing kidney clearing stomach are take in the present invention, a kind of Chinese medicine preparation that is used for the treatment of periodontitis is provided, and its crude drug comprises Rhizoma Drynariae, Fructus Viticis, the Rhizoma Anemarrhenae, Cortex Moutan, Herba Houttuyniae, Caulis Spatholobi, Herba Ecliptae, Radix Scrophulariae, Semen Cuscutae, Rhizoma Polygonati, Radix Paeoniae Rubra, Radix Et Rhizoma Rhei, Rhizoma Polygoni Cuspidati, Radix Changii, Radix Glycyrrhizae, Radix Gentianae Macrophyllae, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), Ramulus Cinnamomi, Rhizoma Curcumae Longae, Herba Selaginellae, Herba Taxilli, Radix Morindae Officinalis, Caulis et folium cryptotaeniae japonicae, Caulis Bauhihiae Championii, Caulis Lonicerae, Fructus Corni, Cortex Acanthopancis, achillea millefolium, Herba Rabdosiae glaucocalycis, Herba Asteris Ageratoidis, Herba Cistanches, Rhizoma Cimicifugae and Rhizoma Panacis Japonici.

Further, described Chinese medicine preparation only consists of above-mentioned raw materials medicine.

In described Chinese medicine preparation, the weight of each crude drug is respectively Rhizoma Drynariae 53g～63g, Fructus Viticis 20g～30g, Rhizoma Anemarrhenae 32g～42g, Cortex Moutan 27g～37g, Herba Houttuyniae 31g～41g, Caulis Spatholobi 39g～49g, Herba Ecliptae 35g～45g, Radix Scrophulariae 29g～39g, Semen Cuscutae 34g～44g, Rhizoma Polygonati 52g～62g, Radix Paeoniae Rubra 29g～39g, Radix Et Rhizoma Rhei 31g～41g, Rhizoma Polygoni Cuspidati 33g～43g, Radix Changii 26g～36g, Radix Glycyrrhizae 21g～31g, Radix Gentianae Macrophyllae 16g～26g, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 22g～32g, Ramulus Cinnamomi 17g～27g, Rhizoma Curcumae Longae 29g～39g, Herba Selaginellae 36g～46g, Herba Taxilli 27g～37g, Radix Morindae Officinalis 25g～35g, Caulis et folium cryptotaeniae japonicae 33g～43g, Caulis Bauhihiae Championii 22g～32g, Caulis Lonicerae 29g～39g, Fructus Corni 23g～33g, Cortex Acanthopancis 41g～51g, achillea millefolium 22g～32g, Herba Rabdosiae glaucocalycis 27g～37g, Herba Asteris Ageratoidis 19g～29g, Herba Cistanches 35g～45g, Rhizoma Cimicifugae 27g～37g and Rhizoma Panacis Japonici 36g～46g.

Further, in described Chinese medicine preparation, the weight of each crude drug is respectively Rhizoma Drynariae 56g～60g, Fructus Viticis 23g～27g, Rhizoma Anemarrhenae 35g～39g, Cortex Moutan 30g～34g, Herba Houttuyniae 34g～38g, Caulis Spatholobi 42g～46g, Herba Ecliptae 38g～42g, Radix Scrophulariae 32g～36g, Semen Cuscutae 37g～41g, Rhizoma Polygonati 55g～59g, Radix Paeoniae Rubra 32g～36g, Radix Et Rhizoma Rhei 34g～38g, Rhizoma Polygoni Cuspidati 36g～40g, Radix Changii 29g～33g, Radix Glycyrrhizae 24g～28g, Radix Gentianae Macrophyllae 19g～23g, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 25g～29g, Ramulus Cinnamomi 20g～24g, Rhizoma Curcumae Longae 32g～36g, Herba Selaginellae 39g～43g, Herba Taxilli 30g～34g, Radix Morindae Officinalis 28g～32g, Caulis et folium cryptotaeniae japonicae 36g～40g, Caulis Bauhihiae Championii 25g～29g, Caulis Lonicerae 32g～36g, Fructus Corni 26g～30g, Cortex Acanthopancis 44g～48g, achillea millefolium 25g～29g, Herba Rabdosiae glaucocalycis 30g～34g, Herba Asteris Ageratoidis 22g～26g, Herba Cistanches 38g～42g, Rhizoma Cimicifugae 30g～34g and Rhizoma Panacis Japonici 39g～43g.

Most preferably, in described Chinese medicine preparation, the weight of each crude drug is respectively Rhizoma Drynariae 58g, Fructus Viticis 25g, Rhizoma Anemarrhenae 37g, Cortex Moutan 32g, Herba Houttuyniae 36g, Caulis Spatholobi 44g, Herba Ecliptae 40g, Radix Scrophulariae 34g, Semen Cuscutae 39g, Rhizoma Polygonati 57g, Radix Paeoniae Rubra 34g, Radix Et Rhizoma Rhei 36g, Rhizoma Polygoni Cuspidati 38g, Radix Changii 31g, Radix Glycyrrhizae 26g, Radix Gentianae Macrophyllae 21, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 27g, Ramulus Cinnamomi 22g, Rhizoma Curcumae Longae 34g, Herba Selaginellae 41g, Herba Taxilli 32g, Radix Morindae Officinalis 30g, Caulis et folium cryptotaeniae japonicae 38g, Caulis Bauhihiae Championii 27g, Caulis Lonicerae 34g, Fructus Corni 28g, Cortex Acanthopancis 46g, achillea millefolium 27g, Herba Rabdosiae glaucocalycis 32g, Herba Asteris Ageratoidis 24g, Herba Cistanches 40g, Rhizoma Cimicifugae 32g and Rhizoma Panacis Japonici 41g.

In described Chinese medicine preparation, the pharmacology of each crude drug is as follows:

Rhizoma Drynariae: bitter in the mouth, warm in nature, enter liver, kidney channel, there is invigorating the kidney and strengthening the bones, continuous effect of hindering pain relieving, for the soreness of waist and knee joint of suffering from a deficiency of the kidney, flaccidity and weakness of the lower limbs, the hepatic and renal YIN deficiency, empty positive rising and the deafness and tinnitus that causes, odontoseisis pain or gingival hemorrhage, asthenia of both the spleen and kidney and cause the cards such as chronic diarrhea chronic dysentery.

Fructus Viticis: acrid in the mouth, hardship, cold nature, returns bladder, liver, stomach warp, has dispelling wind and heat pathogens, and the clear sharp head's effect cures mainly anemopyretic cold headache, gingivitis, the many tear of conjunctival congestion, poor vision, the card such as have a dizzy spell.

The Rhizoma Anemarrhenae: bitter in the mouth, sweet, cold in nature, enter lung, stomach, kidney channel, have rush down clearly stomach-fire, the relieving restlessness of purging heat, the effect of nourshing Yin and drynsessmoistening prescription, clearing away lung-heat to relieve cough, cures mainly fever caused by exogenous pathogenic factors, high heat is irritated, lung-heat type cough, the interior-heat symptom such as quench one's thirst; Its bitter cold matter profit, property sedimentation, can heat clearing away, can promote the production of body fluid again, kindly controls warm pathogenic factor and enters edema caused by disorder of QI, intenseness of heat impairment of body fluid; Also be used for the treatment of diabetes; Phlegm-heat obstructing in the lung and breathing heavily, xeropulmonary cough, expectorant is few unfavorable; Hyperactivity of fire caused by deficiency of YIN, the symptoms such as hyperactivity of deficient fire, the Rhizoma Anemarrhenae has inhibitory action to various bacteria such as dysentery bacterium, Bacillus typhi, escherichia coli, Bacillus proteus, staphylococcus, streptococcus.

Cortex Moutan: cold in nature, bitter in the mouth, cool, enters the heart, liver, kidney, lung meridian, has the effect of clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, for the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, send out speckle, tell nosebleed, the calentura later stage, hot Fu Yin divided heating, deficiency of YIN osteopyrexia and fever, amenorrhea due to stagnation of blood, dysmenorrhea, carbuncle sore tumefacting virus, falls and flutters the pain of injury, the cards such as rheumatism pyretic arthralgia.

Herba Houttuyniae: acrid in the mouth, cold nature, enters lung, urinary bladder channel, has heat-clearing and toxic substances removing, removing pus and relieving carbuncle, the effect of inducing diuresis for treating stranguria syndrome, for lung abscess vomiting pus, expectorant heat syndrome cough is breathed heavily, toxic-heat and blood stasis, damp-heat gonorrhoea, pyretic toxicity carbuncle sore, snakeworm is wanted first-class card.

Caulis Spatholobi: bitter in the mouth, sweet, warm in nature, return liver, kidney channel, there is blood vessel dilating, enrich blood and invigorate blood circulation, regulating menstruation, the effect of relaxing muscles and tendons and activating QI and blood in the collateral, cures mainly the menoxenia that blood deficiency has silt, and limbs pain is meciless, the cards such as soreness of the waist and knees, pain.

Herba Ecliptae: sweet in the mouth, acid, cold in nature, return liver, kidney channel, play liver and kidney tonifying, the effect of cooling blood for hemostasis, for having a dizzy spell due to the hepatic and renal YIN deficiency, blurring of vision, soreness of the waist and knees; Being suitable for the deficiency of YIN has hot person, is used for the treatment of the haematemesis of accumulated heat in stomach, the cards such as the hemoptysis of injury of blood vessel of the lung by heat.

Radix Scrophulariae: sweet in the mouth, hardship, one-tenth, cold nature, returns lung, stomach, kidney channel, there is clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing is supported the effect of kidney, curing mainly pathogenic warmth joins the army, the pericardium that caves in, maculae caused by violent heat pathogen, the cards such as constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus are hindered in consumption of YIN caused by febrile disease, crimson tongue excessive thirst, Tianjin.

Semen Cuscutae: sweet in the mouth, pungent, property is flat, enters liver,kidney,spleen warp, has the kidney invigorating and essence nourishing, and the effect of nourishing the liver to improve visual acuity is mainly used in the sexual impotence of insufficiency of kidney-YANG, seminal emission premature ejaculation, frequent micturition, dizziness and tinnitus; The pain in the lumbar region of suffering from a deficiency of the kidney, married woman's leukorrhagia, nausea is solid; The binocular of both liver and kidney deficiency, deficiency of liver-blood is dim-sighted, blurring of vision; The loose stool stomachache of asthenia of both the spleen and kidney, the symptoms such as aqueous-grainy diarrhea, by adding Semen Cuscutae, promote the reparation of liver and kidney cells, nourishing kidney-yin, protecting liver and detoxication, enhances metabolism, slow down epidemic situation, strengthen resistance against diseases, the generation of simultaneously reduce miscarriage, producing stillborn fetus, weak tire or mummy tire.

Rhizoma Polygonati: sweet in the mouth, property is flat, enters lung, spleen, kidney channel, has the yin nourishing of fostering the spirit of nobility, spleen invigorating lung moistening, the effect of enriching kidney essence, for taste deficiency of qi and yin, lack of appetite is unable, lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, the quenching one's thirst of yin asthenia generating intrinsic heat, the cards such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.

Radix Paeoniae Rubra: bitter in the mouth, micro-hardship, return Liver Channel, there is removing fire from the liver, clearing away heat and cooling blood, the effect of stasis-dispelling and pain-killing, cures mainly the conjunctival congestion and swelling pain that liver-fire is vigorous, has a dizzy spell, pain in chest and hypochondrium, the fever of the body crimson tongue of the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, macule is hemorrhage, and blood stasis amenorrhea; The haematemesis hematuria of the absurd row of burning hot flourishing forcing blood; The trip of women's heat in blood is through too much; The caused various pain of blood retardance; The cards such as furuncle carbuncle of heat in blood poison Sheng.

Radix Et Rhizoma Rhei: bitter in the mouth, cold in nature, return stomach warp; Large intestine channel; Liver Channel; Spleen channel, have attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; The effect of removing toxic substances, cures mainly excess-heat constipation; The accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhea; Edema abdominal distention; Dysuria; Conjunctival congestion; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Gastropyretic vomiting; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Blood-retention; Amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Lump in the abdomen; Traumatic injury; Pyretic toxicity carbuncle and ulcer; Erysipelas; The cards such as scald.

Rhizoma Polygoni Cuspidati: mildly bitter flavor, cold nature, return liver, gallbladder, lung meridian, there is the effect of expelling wind and removing dampness, dissipating blood stasis analgesic therapy, preventing phlegm from forming and stopping coughing, for arthralgia, jaundice due to damp-heat, amenorrhea ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus.

Radix Changii: sweet in the mouth, micro-hardship, cold nature, returns lung, spleen, Liver Channel, has moistening the lung and resolving phlegm, yin nourishing stomach function regulating, the effect of suppressing the hyperactive liver removing toxic substances, for cough due to lung-heat, vomiting regurgitation, lack of appetite xerostomia, the card such as conjunctival congestion is dizzy, furunculosis skin infection.

Radix Glycyrrhizae: sweet in the mouth, property is flat, enters 12 warps, has heat-clearing and toxic substances removing, is in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain, is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, weak; Can alleviate contracture pain in abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, by adding Radix Glycyrrhizae can play QI invigorating, neutralizes, and is in harmonious proportion the effect of each component.

Radix Gentianae Macrophyllae: acrid in the mouth, hardship, cold nature, returns stomach warp, Liver Channel, gallbladder meridian, has wind-damp dispelling, relaxing muscles and tendons network, the effect of clearind deficient heat, cures mainly rheumatic arthralgia, the contracture of muscle arteries and veins, joint is ached, afternoon fever, the cards such as infantile malnutrition heating.

Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati): the flower of Rubiaceae Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) platymiscium Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), sweet in the mouth, light, cool in nature, there is dissipating blood stasis hemostasis, regulating menstruation, blood pressure lowering, liver heat removing, invigorates blood circulation, and the effect of pain relieving, cures mainly hypertension, menoxenia, injured bone, skin infection.Root, stem: hemoptysis of pulmonary tuberculosis, stomachache, rheumatic arthritis, the cards such as traumatic injury.

Ramulus Cinnamomi: be the dry twig warming the meridian and promoting blood circulation of canella Cortex Cinnamomi, acrid in the mouth, sweet, warm in nature, GUIXIN, lung, urinary bladder channel, there is diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, the effect of dispersing cold for relieving pain, horizontal logical podomere, for affection of exogenous wind-cold exterior syndrome, no matter have antiperspirant, losslessly all can apply, also for rheumatic arthralgia, cold syndrome of the stomach stomachache, amenorrhea, dysmenorrhea, rheumatic arthralgia, the cards such as shoulder arm podomere cold type of pain, phlegm retention syndrome and bladder water-retention, heart deficiency of spleen-YANG, retention of water-damp in the body, fullness and distention in the chest and hypochondrium, the dizzy phlegm retention syndrome that waits of cough with dyspnea.

Rhizoma Curcumae Longae: bitter in the mouth, pungent, warm in nature, enter Liver Channel, there is removing blood stasis circulation of qi promoting, the effect of inducing menstruation to relieve menalgia, twinges for the breast side of body, amenorrhea, lump in the abdomen, rheumatism shoulder arm pain, the cards such as tumbling and swelling.

Herba Selaginellae: be the dry herb of Spikemoss plant Herba Selaginellae or cushion Herba Selaginellae, acrid in the mouth, property is flat, returns liver, heart channel, has the effect of promoting blood circulation to restore menstrual flow, and for amenorrhea dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, spits blood, and metrorrhagia, has blood in stool, the cards such as proctoptosis.

Herba Taxilli: bitter in the mouth, sweet, property is flat, returns liver, kidney channel, the effect with invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit, cures mainly the soreness of waist pain due to deficiency of the liver and kindey, and muscles and bones flaccidity is soft, the foot and knee being feeble, deficiency of the liver and kindey, essence and blood is empty to be lost, the frequent fetal movement of liability to abortion, the cards such as waist abdomen pain.

Radix Morindae Officinalis: acrid in the mouth, sweet, warm in nature, return liver, kidney channel, there is reinforcing the kidney and supporting YANG; Bone and muscle strengthening; The effect of expelling wind and removing dampness, cures mainly impotence due to deficiency of the kidney; Seminal emission premature ejaculation; Few abdomen cold type of pain; Incontinence of urine; Cold womb is infertile; Anemofrigid-damp arthralgia; Soreness of the waist and knees; The cards such as rheumatism limb gas.

Caulis et folium cryptotaeniae japonicae: acrid in the mouth, hardship; Property is put down, and has dispelling wind stopping cough; Eliminating damp, detoxifying; The effect of blood-activating analgetic, cures mainly pneumonia, pulmonary abscess, and gonorrhea, hernia, acute toothache, carbuncle furuncle is swollen, herpes zoster, the cards such as skin pruritus.

Caulis Bauhihiae Championii: bitter in the mouth, pungent, property is flat, has expelling wind and removing dampness, and the effect of promoting flow of QI and blood, cures mainly rheumatic arthralgia, traumatic injury, hemiplegia, gastric abscess, infantile malnutrition, the cards such as dysentery.

Caulis Lonicerae: sweet in the mouth, cold in nature, attach to the lung and stomach meridians, there is heat-clearing and toxic substances removing, the effect of dispelling wind dredging collateral, cures mainly epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle skin infection, rheumatism pyretic arthralgia, the cards such as redness and swelling of joints burning pain.

Fructus Corni: sour in the mouth, puckery, slightly warm in nature, returns liver, kidney channel, has liver and kidney tonifying, the effect of essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating collapse.The interior-heat card such as quench one's thirst.

Cortex Acanthopancis: acrid in the mouth, hardship, warm in nature, return liver, kidney, there is wind-damp dispelling; Invigorating the liver and kidney; Bone and muscle strengthening; The invigorate blood circulation effect of arteries and veins, cures mainly anemofrigid-damp arthralgia; Lumbocrural pain; Muscles and bones flaccidity is soft; Children's's walking retardation in children; Body void is frail; Traumatic injury; Fracture; Edema; Foot gas; The uncontrolled urination card such as itch.

Achillea millefolium: acrid in the mouth; Bitter; Property flat temperature, there is wind-expelling pain-stopping; The effect of promoting blood circulation and detoxication, cures mainly cold, fever; Wind syndrome of head pain; Toothache; Rheumatic arthralgia; Blood stasis amenorrhea; Abdominal part mass in the abdomen; Traumatic injury; Venom; The cards such as carbuncle sore tumefacting virus.

Herba Rabdosiae glaucocalycis: bitter in the mouth, pungent, gas is fragrant, and cool in nature, GUIXIN, liver, spleen channel, have clearing away heat-damp and promoting diuresis, and the effect of promoting blood circulation and detoxication, cures mainly jaundice due to damp-heat, stranguria, edema, laryngopharynx swelling and pain, arthralgia, amenorrhea, acute mastitis, hemorrhoid, traumatic injury, the cards such as venom.

Herba Asteris Ageratoidis: bitter in the mouth, pungent, cool in nature, there is heat-clearing and toxic substances removing, the effect of the removing heat from blood that eliminates the phlegm, cures mainly cold, fever, tonsillitis, bronchitis, hepatitis, enteritis, pyretic stranguria, carbuncle furunculosis, the cards such as snake bite and insect sting.

Herba Cistanches: sweet in the mouth, one-tenth, warm in nature, enter kidney, large intestine channel, has kidney-replenishing, benefiting essence-blood, the effect of loosening bowel to relieve constipation, for kidney yang deficiency, the impotence and premature ejaculation of asthenia of essence and blood, sterility and infertility, soreness of waist and knee joint, Hiccough and deaf, frequent micturition urine number, suffer from a deficiency of the kidney dryness of the intestine and puerperal blood deficiency, the cards such as constipation of deficiency of body fluid after being ill.

Rhizoma Cimicifugae: acrid in the mouth, micro-sweet, cold nature, enters lung, spleen, stomach, large intestine channel, has the rash of delivering, heat-clearing and toxic substances removing, the effect of elevate a turnable ladder yang-energy.For headache due to pathogenic wind-heat, toothache, aphtha, laryngopharynx swelling and pain, measles without adequate eruption, YANG toxin syndrome is sent out speckle; Proctoptosis, the cards such as uterine prolapse.

Rhizoma Panacis Japonici: sweet in the mouth, micro-hardship, warm in nature, return liver, spleen, lung meridian, there is strengthening by means of tonics, eliminating stasis to stop pain, the effect that hemostasis is eliminated the phlegm, cures mainly weakness after being ill, chronic cough spitting of blood, cough with copious phlegm, the cards such as injury from falling down.

Described Chinese medicine preparation can be prepared into powder and oral liquid.

The powder that the present invention also provides above-mentioned Chinese medicine preparation to be prepared into, is specially:

The first step, Rhizoma Drynariae, Cortex Moutan, Caulis Spatholobi, Herba Ecliptae, Radix Scrophulariae, Semen Cuscutae, Rhizoma Polygonati, Radix Paeoniae Rubra, Radix Morindae Officinalis, Fructus Corni, Cortex Acanthopancis, Herba Cistanches and Rhizoma Panacis Japonici are pulverized respectively, mix by weight, obtain mixture, in the ethanol that to add with respect to 4～6 times of determining alcohols of mixture quality be 70%～80%, flood 24 hours～36 hours, adopt percolation with the speed of 2～4ml per minute percolation slowly, collect percolate, percolate concentrating under reduced pressure, obtain and get dry extract, be ground into powder;

Second step, pulverizes component under She respectively, mixes by weight, add in cold water and soak 3 hours～5 hours, with slow fire boiling 2 hours～3 hours, the quality of the cold water adding was 2～4 times of the mixture quality that obtains of the first step, decoction liquor is filtered, and filtering residue was put into cold water again, with slow fire boiling 1 hour～2 hours, the quality of the cold water adding is 1～2 times of the mixture quality that obtains of the first step, merge filtrate, concentrating under reduced pressure, except anhydrating, obtain and get dry extract, be ground into powder;

The 3rd step, the powder of the first step and second step acquisition is mixed, add with respect to the protein sugar of 0.01～0.05 times of its quality, the dextrin of 0.1～0.2 times, the starch of 1～2 times is put into blender and is stirred 30 minutes～1 hour, make powder, with racking machine subpackage.

The oral liquid that the present invention also provides above-mentioned Chinese medicine preparation to be prepared into, is specially:

The first step, Rhizoma Drynariae, Cortex Moutan, Caulis Spatholobi, Herba Ecliptae, Radix Scrophulariae, Semen Cuscutae, Rhizoma Polygonati, Radix Paeoniae Rubra, Radix Morindae Officinalis, Fructus Corni, Cortex Acanthopancis, Herba Cistanches and Rhizoma Panacis Japonici are pulverized respectively, mix by weight, obtain mixture, in the ethanol that to add with respect to 4～6 times of determining alcohols of mixture quality be 70%～80%, flood 24 hours～36 hours, adopt percolation with the speed of 2～4ml per minute percolation slowly, collect percolate, percolate concentrating under reduced pressure, obtain and get dry extract, be ground into powder;

Second step, pulverizes component under She respectively, mixes by weight, add in cold water and soak 3 hours～5 hours, with slow fire boiling 2 hours～3 hours, the quality of the cold water adding was 2～4 times of the mixture quality that obtains of the first step, decoction liquor is filtered, and filtering residue was put into cold water again, with slow fire boiling 1 hour～2 hours, the quality of the cold water adding is 1～2 times of the mixture quality that obtains of the first step, merge filtrate, concentrating under reduced pressure, except anhydrating, obtain and get dry extract, be ground into powder;

The 3rd step, mixes the powder of the first step and second step acquisition, adds the distilled water with respect to 3～5 times of amounts of powder quality, the sucrose of 0.1～0.3 times, and the sodium benzoate of 0.01～0.02 times, stirs, and boils, cooling, filter, subpackage, sterilizing obtains oral liquid.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.

Embodiment 1 powder 1

By Rhizoma Drynariae 58g, Cortex Moutan 32g, Caulis Spatholobi 44g, Herba Ecliptae 40g, Radix Scrophulariae 34g, Semen Cuscutae 39g, Rhizoma Polygonati 57g, Radix Paeoniae Rubra 34g, Radix Morindae Officinalis 30g, Fructus Corni 28g, Cortex Acanthopancis 46g, Herba Cistanches 40g and Rhizoma Panacis Japonici 41g mix, and obtain mixture, and adding 2.6kg determining alcohol is, in 80% ethanol, to flood 36 hours, adopt percolation with the speed of 3ml per minute percolation slowly, collect percolate, percolate concentrating under reduced pressure, obtain and get dry extract, be ground into powder, by Fructus Viticis 25g, Rhizoma Anemarrhenae 37g, Herba Houttuyniae 36g, Radix Et Rhizoma Rhei 36g, Rhizoma Polygoni Cuspidati 38g, Radix Changii 31g, Radix Glycyrrhizae 26g, Radix Gentianae Macrophyllae 21g, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 27g, Ramulus Cinnamomi 22g, Rhizoma Curcumae Longae 34g, Herba Selaginellae 41g, Herba Taxilli 32g, Caulis et folium cryptotaeniae japonicae 38g, Caulis Bauhihiae Championii 27g, Caulis Lonicerae 34g, achillea millefolium 27g, Herba Rabdosiae glaucocalycis 32g, Herba Asteris Ageratoidis 24g, Rhizoma Cimicifugae 32g pulverizes respectively, mixes, and adds in 1.8kg cold water and soaks 4 hours, with slow fire boiling 3 hours, decoction liquor is filtered, filtering residue is put into 1kg cold water again, with slow fire boiling 2 hours, merge filtrate, concentrating under reduced pressure, except anhydrating, obtain and get dry extract, be ground into powder, the powder obtaining is above mixed, add 20g protein sugar, 150g dextrin, the starch of 1.5kg is put into blender and is stirred 1 hour, makes powder 1, with racking machine subpackage.

Toxicological experiment

Acute toxicity test in mice conclusion: the powder of embodiment 1 preparation is dissolved in water, obtains the solution of 1g/ml, gavage gives, after ICR mice, not measure LD ₅₀, recording maximum dosage-feeding is 48g medicated powder/kg, is equivalent to 150g crude drug/kg, is to intend clinical people with 750 times of dosage.

Rat chronic toxicity test

With 120 of rats, by body weight sex, be divided at random 4 groups, every group 30, male and female half and half, with Chinese powder medicine 1, maximum dosage-feeding 7.2g medicated powder/kg is as the heavy dose of rat chronic toxicity test, and three dosage are respectively 7.2g medicated powder/kg, 3.6g medicated powder/kg, 1.8g medicated powder/kg, is equivalent to intend 122.5 times, 56.2 times, 28.1 times of quantity.Gavage awards rat 180 days, every day gastric infusion once, administration is 6 days weekly.

1. the observation to rat general status: administration group and control rats are all movable normal within 6 months experimental periods and convalescent period, and behavior is active, and hair is smooth, has no feces abnormal, without pathological changes such as secretions and dyspnea.

2. the impact on rat body weight:, Some Animals loses weight for three dosage groups of Chinese medicine preparation provided by the invention and control animals weight ratio.

3. the impact on rat food ration and water uptake: administration treated animal food ration and water uptake and control animals change basically identical.

4. the impact on Rats Organs and Tissues coefficient: the heart, liver, spleen, lung, kidney, brain, adrenal gland, thymus, testis, prostate, ovary, uterus organ coefficient statistics and the comparison of water matched group, unknown significance difference.

5. rat blood is learned the impact of index: administration group hematological indices and matched group comparison, leukocyte differential count and matched group comparison, difference has significance (P<0.05, P<0.01), but all within normal range (normal range: lymphocyte 66%-84%, neutrophil(e) cell 9%-34%), therefore abiology meaning.Administration is erythrocyte and reticulocyte and matched group comparison after 3 months, and (P<0.05, P<0.01) significantly raises, but fluctuation range is less, administration 6 months and convalescent period no significant difference, belong to the fluctuation of normal physiology, abiology meaning.In convalescent period, dosage HGB and PLT and matched group relatively have significant difference (P<0.05, P<0.01), but fluctuation range is less, belong to normal physiology fluctuation, abiology meaning.Other hematological indices Non Apparent Abnormalities.

6. the impact on rat blood biochemical indicator: administration group blood parameters and matched group comparison, administration 3 months, in this product, dosage ALT significantly reduces (P<0.01), Cr heavy dose of and middle dosage significantly reduces (P<0.01, P<0.05), administration 3 months and convalescent period, GLU heavy dose of and middle dosage has fluctuation (P<0.01, P<0.05), from data, amplitude of variation is very little, belongs to normal physiology fluctuation, abiology meaning.This product has no significant effect rat blood biochemical indicator.

7. the inspection to rat histopathology: to administration 3 months, the matched group that 6 months and drug withdrawal convalescent period put to death and all internal organs of heavy dose of treated animal and tissue have carried out comprehensive and systematic histological observation, and organize and matched group paired observation by heavy dose, think the heart of Chinese medicine preparation provided by the invention to rat, kidney, spleen, brain, hypophysis, adrenal gland, thymus, thyroid, pancreas, stomach, duodenum, ileum, colon, testis, prostate, bladder, uterus, ovary, mesenteric lymph node, breast bone, spinal cord, optic nervies etc. are without pathologic damaging action, hepatocyte edema occurs matched group and heavy dose of group, may be irrelevant with administration, matched group and heavy dose of group all have interstitial pneumonia to distribute, how by viral infection, to be caused, and irrelevant with administration.In conjunction with hematological indices and blood biochemical, learn index known: Chinese medicine preparation provided by the invention to the various organs and tissues of rat without pathologic damaging action.

Conclusion: result of the test shows, under this experimental condition, Chinese medicine preparation provided by the invention all has no significant effect the ordinary circumstance of rat, diet drinking-water, hematology, blood biochemical, system dissection, organ coefficient and histopathology, Some Animals loses weight, does not find obvious long term toxicity reaction, convalescent period is also without retardance toxic reaction, results suggest: Chinese medicine preparation gavage provided by the invention gives rat 180 days, the nontoxic amounts of reactants of rat is 7.2g medicated powder/kg day, 19.1g crude drug/kg day.

Toxicological experiment shows that this product has certain safety, taking convenience, and safely, have no side effect, drug effect is clear and definite, have significant clinical application prospect.

Embodiment 2 powders 2

By Rhizoma Drynariae 56g, Cortex Moutan 30g, Caulis Spatholobi 42g, Herba Ecliptae 38g, Radix Scrophulariae 32g, Semen Cuscutae 37g, Rhizoma Polygonati 55g, Radix Paeoniae Rubra 32g, Radix Morindae Officinalis 28g, Fructus Corni 26g, Cortex Acanthopancis 44g, Herba Cistanches 38g and Rhizoma Panacis Japonici 39g mix, and obtain mixture, and adding 2.5kg determining alcohol is, in 80% ethanol, to flood 36 hours, adopt percolation with the speed of 3ml per minute percolation slowly, collect percolate, percolate concentrating under reduced pressure, obtain and get dry extract, be ground into powder, by Fructus Viticis 23g, Rhizoma Anemarrhenae 35g, Herba Houttuyniae 34g, Radix Et Rhizoma Rhei 34g, Rhizoma Polygoni Cuspidati 36g, Radix Changii 29g, Radix Glycyrrhizae 24g, Radix Gentianae Macrophyllae 19g, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 25g, Ramulus Cinnamomi 20g, Rhizoma Curcumae Longae 32g, Herba Selaginellae 39g, Herba Taxilli 30g, Caulis et folium cryptotaeniae japonicae 36g, Caulis Bauhihiae Championii 25g, Caulis Lonicerae 32g, achillea millefolium 25g, Herba Rabdosiae glaucocalycis 30g, Herba Asteris Ageratoidis 22g, Rhizoma Cimicifugae 30g pulverizes respectively, mixes, and adds in 1.8kg cold water and soaks 4 hours, with slow fire boiling 3 hours, decoction liquor is filtered, filtering residue is put into 1kg cold water again, with slow fire boiling 2 hours, merge filtrate, concentrating under reduced pressure, except anhydrating, obtain and get dry extract, be ground into powder, the powder obtaining is above mixed, add 20g protein sugar, 150g dextrin, the starch of 1.5kg is put into blender and is stirred 1 hour, makes powder 2, with racking machine subpackage.

Embodiment 3 powders 3

By Rhizoma Drynariae 60g, Cortex Moutan 34g, Caulis Spatholobi 46g, Herba Ecliptae 42g, Radix Scrophulariae 36g, Semen Cuscutae 41g, Rhizoma Polygonati 59g, Radix Paeoniae Rubra 36g, Radix Morindae Officinalis 32g, Fructus Corni 30g, Cortex Acanthopancis 48g, Herba Cistanches 42g and Rhizoma Panacis Japonici 43g mix, and obtain mixture, and adding 2.6kg determining alcohol is, in 80% ethanol, to flood 36 hours, adopt percolation with the speed of 3ml per minute percolation slowly, collect percolate, percolate concentrating under reduced pressure, obtain and get dry extract, be ground into powder, by Fructus Viticis 27g, Rhizoma Anemarrhenae 39g, Herba Houttuyniae 38g, Radix Et Rhizoma Rhei 38g, Rhizoma Polygoni Cuspidati 40g, Radix Changii 33g, Radix Glycyrrhizae 28g, Radix Gentianae Macrophyllae 23g, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 29g, Ramulus Cinnamomi 24g, Rhizoma Curcumae Longae 36g, Herba Selaginellae 43g, Herba Taxilli 34g, Caulis et folium cryptotaeniae japonicae 40g, Caulis Bauhihiae Championii 29g, Caulis Lonicerae 36g, achillea millefolium 29g, Herba Rabdosiae glaucocalycis 34g, Herba Asteris Ageratoidis 26g, Rhizoma Cimicifugae 34g pulverizes respectively, mixes, and adds in 2kg cold water and soaks 4 hours, with slow fire boiling 3 hours, decoction liquor is filtered, filtering residue is put into 1kg cold water again, with slow fire boiling 2 hours, merge filtrate, concentrating under reduced pressure, except anhydrating, obtain and get dry extract, be ground into powder, the powder obtaining is above mixed, add 20g protein sugar, 150g dextrin, the starch of 1.5kg is put into blender and is stirred 1 hour, makes powder 3, with racking machine subpackage.

Embodiment 4 oral liquids

By Rhizoma Drynariae 60g, Cortex Moutan 34g, Caulis Spatholobi 46g, Herba Ecliptae 42g, Radix Scrophulariae 36g, Semen Cuscutae 41g, Rhizoma Polygonati 59g, Radix Paeoniae Rubra 36g, Radix Morindae Officinalis 32g, Fructus Corni 30g, Cortex Acanthopancis 48g, Herba Cistanches 42g and Rhizoma Panacis Japonici 43g mix, and obtain mixture, and adding 2.6kg determining alcohol is, in 80% ethanol, to flood 36 hours, adopt percolation with the speed of 3ml per minute percolation slowly, collect percolate, percolate concentrating under reduced pressure, obtain and get dry extract, be ground into powder, by Fructus Viticis 27g, Rhizoma Anemarrhenae 39g, Herba Houttuyniae 38g, Radix Et Rhizoma Rhei 38g, Rhizoma Polygoni Cuspidati 40g, Radix Changii 33g, Radix Glycyrrhizae 28g, Radix Gentianae Macrophyllae 23g, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 29g, Ramulus Cinnamomi 24g, Rhizoma Curcumae Longae 36g, Herba Selaginellae 43g, Herba Taxilli 34g, Caulis et folium cryptotaeniae japonicae 40g, Caulis Bauhihiae Championii 29g, Caulis Lonicerae 36g, achillea millefolium 29g, Herba Rabdosiae glaucocalycis 34g, Herba Asteris Ageratoidis 26g, Rhizoma Cimicifugae 34g pulverizes respectively, mixes, and adds in 2kg cold water and soaks 4 hours, with slow fire boiling 3 hours, decoction liquor is filtered, and filtering residue is put into 1kg cold water again, with slow fire boiling 2 hours, merges filtrate, concentrating under reduced pressure, except anhydrating, obtains and gets dry extract, and is ground into powder, the powder obtaining is above mixed, obtain 500g powder, add 2kg distilled water, the sucrose of 70g, the sodium benzoate of 7g, stirs, and boils, cooling, filter, subpackage, sterilizing obtains oral liquid.

Embodiment 5 clinical datas

Physical data

Select patients with periodontitis totally 180 examples, adopt table of random number method that patient is divided into two groups at random, each 90 examples, 36～54 years old treatment group age, average 46.2 years old, the course of disease 6 months～6 years; Matched group 90 examples, 38～54 years old age, average 46.5 years old, the course of disease 5 months～6 years; Two groups of patients aspect age, sex, the course of disease difference not statistically significant ((P>0.05), has comparability.

Therapeutic Method

Matched group: topical therapeutic comprise under scaling on gum, gum, scrape control, 3%H ₂o ₂periodontal pocket rinses root planing, adjusts to grit one's teeth to close and remove abnormal make a concerted effort, pull out the trouble tooth that can not retain, oral hygiene guidance etc.Whole body therapeutic comprise Metronidazole Tablet and Levofloxacin Hydrochloride Capsules oral 1 month (Metronidazole Tablet, Beijing dawn Pharmaceutical responsibility company limited, the accurate word H11021060 of traditional Chinese medicines, every 0.1g, each 0.2g, every day 2 times, oral; Levofloxacin Hydrochloride Capsules, Yangzijiang Pharmaceutical Group Co., Ltd, the accurate word H19990051 of traditional Chinese medicines, every 0.1g, each 0.2g, every day 2 times, oral).

Treatment group: topical therapeutic comprise under scaling on gum, gum, scrape control, 3%H ₂o ₂periodontal pocket rinses root planing, adjusts to grit one's teeth to close and remove abnormal make a concerted effort, pull out the trouble tooth that can not retain, oral hygiene guidance etc.Whole body therapeutic comprises the powder 1 of the oral embodiment of the present invention 1 preparation, is dissolved in water, oral, every day 3 times, each 100g.

All take 1 month as 1 course for the treatment of, serve on 2 courses for the treatment of for two groups.

Observation index

Gingival index (GI) classification: 0 grade: gingiva is normal; 1 grade: gingiva mild inflammation, gum edge color and luster changes, and spy is examined not hemorrhage; 2 grades: moderate inflammation, red swelling of gingiva involves attached gingiva, and spy is examined hemorrhage; 3 grades: hyperphlogosis, gingiva is obviously red and swollen rotten to the corn, spontaneous hemorrhage.

Periodontal pocket PD

With periodontal probe, measure, suffer from the darkest depth of pocket of each facing of tooth, it is unit that the degree of depth of periodontal pocket of measuring identical diseased region during further consultation be take millimeter (mm).

The plaque index of every tooth (Plaque index, PLI) divides 4 grades

0 grade: on the facing at nearly gum edge place without bacterial plaque; 1 grade: be invisible to the naked eye, while streaking on the facing in nearly free gum district with the side of probe pinpoint, could find thin bacterial plaque; 2 grades: Yin Yuan district or tooth proximal surface have macroscopic moderate bacterial plaque; 3 grades: in gingival sulcus and (or) Yin Yuan district and contiguous facing have a large amount of bacterial plaques to pile up.

Sulcular bleeding index (SBI) is divided 6 grades

0 grade: gingiva is healthy, visit and examine without hemorrhage; 1 grade: spy is examined hemorrhage, and gum nipple and marginal gingiva are without edema and color change; 2 grades: spy is examined hemorrhage, and gum nipple and marginal gingiva have color change, without edema; 3 grades: spy is examined hemorrhage, gum nipple and marginal gingiva color change, Mild edema; 4 grades: spy is examined rear hemorrhage, gum nipple and marginal gingiva color change, obviously edema; 5 grades: spy is examined hemorrhage, there are spontaneous hemorrhage and color change and edema.

Criterion of therapeutical effect

Effective: pain disappears, and General Symptoms significantly alleviates, local red swelling of gingiva disappears, and without rheuminess thing, odontoseisis II degree transfers I degree to, and gingival atrophy is without significant change.Effective: dental pain disappears, and General Symptoms alleviates, and red swelling of gingiva significantly alleviates, and substantially without inflammatory exudate, odontoseisis alleviates, and gingival atrophy is unchanged.Invalid: before treatment, but general without increasing the weight of situation.

Statistical method

Adopt SPSS14.0 software to add up.Between the group of measurement data, relatively with t, check ranked data rank test.

Result

Curative effect comparison, the results are shown in Table 1.

Table 1 liang group therapeutic effect comparison

Group	Number of cases	Effective	Effectively	Invalid	Total effective rate
						Treatment group	90	49	33	8	91.1％
Matched group	90	23	35	32	64.4％

As can be seen from Table 1, adopt the successful of Chinese medicine preparation of the present invention to be better than matched group, P<0.01.

Before and after two groups of patient treatments, the comparison of every periodontal index, the results are shown in Table 2.

Every periodontal index comparison before and after table 2 liang group patient treatment

Group

Time

Number of cases

GI

SBI

PD(mm)

PLI

Treatment group

Before treatment

90

2.21±0.67

2.43±0.12

5.92±0.41

2.91±0.37

?

After treatment

90

0.32±0.17

1.03±0.15

4.17±0.24

0.39±0.14

Matched group

Before treatment

90

2.34±0.76

2.52±0.18

6.09±0.48

2.87±0.72

?

After treatment

90

1.26±0.25

1.76±0.33

5.08±0.43

1.22±0.17

Table 2 shows all there is decline (P<0.05) before GI, SBI, PD and the PLI after two groups of treatments treats; After treatment, GI, SBI, PD and the PLI for the treatment of group all reduce (P<0.05) compared with matched group.

All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (10)

1. a Chinese medicine preparation that is used for the treatment of periodontitis, is characterized in that: crude drug comprises Rhizoma Drynariae, Fructus Viticis, the Rhizoma Anemarrhenae, Cortex Moutan, Herba Houttuyniae, Caulis Spatholobi, Herba Ecliptae, Radix Scrophulariae, Semen Cuscutae, Rhizoma Polygonati, Radix Paeoniae Rubra, Radix Et Rhizoma Rhei, Rhizoma Polygoni Cuspidati, Radix Changii, Radix Glycyrrhizae, Radix Gentianae Macrophyllae, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), Ramulus Cinnamomi, Rhizoma Curcumae Longae, Herba Selaginellae, Herba Taxilli, Radix Morindae Officinalis, Caulis et folium cryptotaeniae japonicae, Caulis Bauhihiae Championii, Caulis Lonicerae, Fructus Corni, Cortex Acanthopancis, achillea millefolium, Herba Rabdosiae glaucocalycis, Herba Asteris Ageratoidis, Herba Cistanches, Rhizoma Cimicifugae and Rhizoma Panacis Japonici.

2. Chinese medicine preparation as claimed in claim 1, it is characterized in that: the weight of each crude drug is respectively Rhizoma Drynariae 53g～63g, Fructus Viticis 20g～30g, Rhizoma Anemarrhenae 32g～42g, Cortex Moutan 27g～37g, Herba Houttuyniae 31g～41g, Caulis Spatholobi 39g～49g, Herba Ecliptae 35g～45g, Radix Scrophulariae 29g～39g, Semen Cuscutae 34g～44g, Rhizoma Polygonati 52g～62g, Radix Paeoniae Rubra 29g～39g, Radix Et Rhizoma Rhei 31g～41g, Rhizoma Polygoni Cuspidati 33g～43g, Radix Changii 26g～36g, Radix Glycyrrhizae 21g～31g, Radix Gentianae Macrophyllae 16g～26g, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 22g～32g, Ramulus Cinnamomi 17g～27g, Rhizoma Curcumae Longae 29g～39g, Herba Selaginellae 36g～46g, Herba Taxilli 27g～37g, Radix Morindae Officinalis 25g～35g, Caulis et folium cryptotaeniae japonicae 33g～43g, Caulis Bauhihiae Championii 22g～32g, Caulis Lonicerae 29g～39g, Fructus Corni 23g～33g, Cortex Acanthopancis 41g～51g, achillea millefolium 22g～32g, Herba Rabdosiae glaucocalycis 27g～37g, Herba Asteris Ageratoidis 19g～29g, Herba Cistanches 35g～45g, Rhizoma Cimicifugae 27g～37g and Rhizoma Panacis Japonici 36g～46g.

3. Chinese medicine preparation as claimed in claim 1 or 2, it is characterized in that: in described Chinese medicine preparation, the weight of each crude drug is respectively Rhizoma Drynariae 56g～60g, Fructus Viticis 23g～27g, Rhizoma Anemarrhenae 35g～39g, Cortex Moutan 30g～34g, Herba Houttuyniae 34g～38g, Caulis Spatholobi 42g～46g, Herba Ecliptae 38g～42g, Radix Scrophulariae 32g～36g, Semen Cuscutae 37g～41g, Rhizoma Polygonati 55g～59g, Radix Paeoniae Rubra 32g～36g, Radix Et Rhizoma Rhei 34g～38g, Rhizoma Polygoni Cuspidati 36g～40g, Radix Changii 29g～33g, Radix Glycyrrhizae 24g～28g, Radix Gentianae Macrophyllae 19g～23g, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 25g～29g, Ramulus Cinnamomi 20g～24g, Rhizoma Curcumae Longae 32g～36g, Herba Selaginellae 39g～43g, Herba Taxilli 30g～34g, Radix Morindae Officinalis 28g～32g, Caulis et folium cryptotaeniae japonicae 36g～40g, Caulis Bauhihiae Championii 25g～29g, Caulis Lonicerae 32g～36g, Fructus Corni 26g～30g, Cortex Acanthopancis 44g～48g, achillea millefolium 25g～29g, Herba Rabdosiae glaucocalycis 30g～34g, Herba Asteris Ageratoidis 22g～26g, Herba Cistanches 38g～42g, Rhizoma Cimicifugae 30g～34g and Rhizoma Panacis Japonici 39g～43g.

4. the Chinese medicine preparation as described in claims 1 to 3, it is characterized in that: in described Chinese medicine preparation, the weight of each crude drug is respectively Rhizoma Drynariae 58g, Fructus Viticis 25g, Rhizoma Anemarrhenae 37g, Cortex Moutan 32g, Herba Houttuyniae 36g, Caulis Spatholobi 44g, Herba Ecliptae 40g, Radix Scrophulariae 34g, Semen Cuscutae 39g, Rhizoma Polygonati 57g, Radix Paeoniae Rubra 34g, Radix Et Rhizoma Rhei 36g, Rhizoma Polygoni Cuspidati 38g, Radix Changii 31g, Radix Glycyrrhizae 26g, Radix Gentianae Macrophyllae 21, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 27g, Ramulus Cinnamomi 22g, Rhizoma Curcumae Longae 34g, Herba Selaginellae 41g, Herba Taxilli 32g, Radix Morindae Officinalis 30g, Caulis et folium cryptotaeniae japonicae 38g, Caulis Bauhihiae Championii 27g, Caulis Lonicerae 34g, Fructus Corni 28g, Cortex Acanthopancis 46g, achillea millefolium 27g, Herba Rabdosiae glaucocalycis 32g, Herba Asteris Ageratoidis 24g, Herba Cistanches 40g, Rhizoma Cimicifugae 32g and Rhizoma Panacis Japonici 41g.

5. the Chinese medicine preparation as described in claim 1 to 4, is characterized in that: the dosage form of described Chinese medicine preparation is powder and oral liquid.

6. the Chinese medicine preparation as described in claim 1 to 5, is characterized in that: during powder that described Chinese medicine preparation is prepared into, adopt mode for oral administration, every day 3 times, each 100g.

7. the preparation method of Chinese medicine preparation described in claim 1 to 6, is characterized in that: when powder that described Chinese medicine preparation is prepared into, is specially,

The first step, Rhizoma Drynariae, Cortex Moutan, Caulis Spatholobi, Herba Ecliptae, Radix Scrophulariae, Semen Cuscutae, Rhizoma Polygonati, Radix Paeoniae Rubra, Radix Morindae Officinalis, Fructus Corni, Cortex Acanthopancis, Herba Cistanches and Rhizoma Panacis Japonici are pulverized respectively, mix by weight, obtain mixture, in the ethanol that to add with respect to 4～6 times of determining alcohols of mixture quality be 70%～80%, flood 24 hours～36 hours, adopt percolation with the speed of 2～4ml per minute percolation slowly, collect percolate, percolate concentrating under reduced pressure, obtain and get dry extract, be ground into powder;

Second step, pulverizes component under She respectively, mixes by weight, add in cold water and soak 3 hours～5 hours, with slow fire boiling 2 hours～3 hours, the quality of the cold water adding was 2～4 times of the mixture quality that obtains of the first step, decoction liquor is filtered, and filtering residue was put into cold water again, with slow fire boiling 1 hour～2 hours, the quality of the cold water adding is 1～2 times of the mixture quality that obtains of the first step, merge filtrate, concentrating under reduced pressure, except anhydrating, obtain and get dry extract, be ground into powder;

The 3rd step, the powder of the first step and second step acquisition is mixed, and with respect to the protein sugar of 0.01～0.05 times of its quality, the dextrin of 0.1～0.2 times, the starch of 1～2 times is put into blender and is stirred 30 minutes～1 hour, make powder, with racking machine subpackage.

8. the preparation method of Chinese medicine preparation described in claim 1 to 7, is characterized in that: when oral liquid that described Chinese medicine preparation is prepared into, is specially,

The first step, Rhizoma Drynariae, Cortex Moutan, Caulis Spatholobi, Herba Ecliptae, Radix Scrophulariae, Semen Cuscutae, Rhizoma Polygonati, Radix Paeoniae Rubra, Radix Morindae Officinalis, Fructus Corni, Cortex Acanthopancis, Herba Cistanches and Rhizoma Panacis Japonici are pulverized respectively, mix by weight, obtain mixture, in the ethanol that to add with respect to 4～6 times of determining alcohols of mixture quality be 70%～80%, flood 24 hours～36 hours, adopt percolation with the speed of 2～4ml per minute percolation slowly, collect percolate, percolate concentrating under reduced pressure, obtain and get dry extract, be ground into powder;

Second step, pulverizes component under She respectively, mixes by weight, add in cold water and soak 3 hours～5 hours, with slow fire boiling 2 hours～3 hours, the quality of the cold water adding was 2～4 times of the mixture quality that obtains of the first step, decoction liquor is filtered, and filtering residue was put into cold water again, with slow fire boiling 1 hour～2 hours, the quality of the cold water adding is 1～2 times of the mixture quality that obtains of the first step, merge filtrate, concentrating under reduced pressure, except anhydrating, obtain and get dry extract, be ground into powder;

The 3rd step, mixes the powder of the first step and second step acquisition, adds the distilled water with respect to 3～5 times of amounts of powder quality, the sucrose of 0.1～0.3 times, and the sodium benzoate of 0.01～0.02 times, stirs, and boils, cooling, filter, subpackage, sterilizing obtains oral liquid.

9. a Chinese powder medicine that is used for the treatment of periodontitis, is characterized in that: crude drug comprises Rhizoma Drynariae, Fructus Viticis, the Rhizoma Anemarrhenae, Cortex Moutan, Herba Houttuyniae, Caulis Spatholobi, Herba Ecliptae, Radix Scrophulariae, Semen Cuscutae, Rhizoma Polygonati, Radix Paeoniae Rubra, Radix Et Rhizoma Rhei, Rhizoma Polygoni Cuspidati, Radix Changii, Radix Glycyrrhizae, Radix Gentianae Macrophyllae, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), Ramulus Cinnamomi, Rhizoma Curcumae Longae, Herba Selaginellae, Herba Taxilli, Radix Morindae Officinalis, Caulis et folium cryptotaeniae japonicae, Caulis Bauhihiae Championii, Caulis Lonicerae, Fructus Corni, Cortex Acanthopancis, achillea millefolium, Herba Rabdosiae glaucocalycis, Herba Asteris Ageratoidis, Herba Cistanches, Rhizoma Cimicifugae and Rhizoma Panacis Japonici.

10. a Chinese medicine oral liquid that is used for the treatment of periodontitis, is characterized in that: crude drug comprises Rhizoma Drynariae, Fructus Viticis, the Rhizoma Anemarrhenae, Cortex Moutan, Herba Houttuyniae, Caulis Spatholobi, Herba Ecliptae, Radix Scrophulariae, Semen Cuscutae, Rhizoma Polygonati, Radix Paeoniae Rubra, Radix Et Rhizoma Rhei, Rhizoma Polygoni Cuspidati, Radix Changii, Radix Glycyrrhizae, Radix Gentianae Macrophyllae, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), Ramulus Cinnamomi, Rhizoma Curcumae Longae, Herba Selaginellae, Herba Taxilli, Radix Morindae Officinalis, Caulis et folium cryptotaeniae japonicae, Caulis Bauhihiae Championii, Caulis Lonicerae, Fructus Corni, Cortex Acanthopancis, achillea millefolium, Herba Rabdosiae glaucocalycis, Herba Asteris Ageratoidis, Herba Cistanches, Rhizoma Cimicifugae and Rhizoma Panacis Japonici.