CN101259210A - Chinese medicinal composition for treating periodontitis and preparation thereof - Google Patents

Abstract

The present invention relates to a Chinese medicine compound for curing peridentitis, containing rehmannia root, wolfberry bark, lychee, cooked rehmannia root, lilyturf root, chrysanthemum, liquorice, figwort root, radix codonopsis pilosulae, rhizoma anemarrhenae, baical skullcap, yanhusuo, Chinese scholartree bud, achyranthes root and/or an acceptable carrier in pharmacology. The present invention also relates to a preparation method of the Chinese medicine compound. The Chinese medicine compound provided by the present invention has the effects of purifying stomach biopsy, reducing swelling and dispelling wind, stimulating blood circulation and releasing stagnant, etc. which is used for curing gum swelling, bleeding and other symptoms caused by peridentitis.

Description

A kind of Chinese medicine composition for the treatment of periodontitis and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine composition, specifically, relate to a kind of Chinese medicine composition for the treatment of periodontitis and preparation method thereof.

Background technology

Periodontitis is a chronic inflammatory disease of invading gingiva and periodontal tissue, is a kind of destructive disease, and its principal character is the formation of periodontal pocket and the inflammation of bag wall, and frontal resorption and tooth are loosening gradually, and it is the main cause that causes adult's loss of tooth.Many because the bacterial plaque of primary disease, tartar, food impaction, bad dummy is stung wound etc. and is caused that various focusing depths represented swelling makes bacterial plaque pile up simultaneously and increases the weight of, and is expanded down by gingivally on the gum and to prolong.Because microecological environment under the gum is growing a large amount of bigger periodontal pathogenic bacterium of virulence, as the gingiva bacteroid in the subgingival plaque, intermediate bacillus, spirillums etc. increase the weight of the inflammation of gingiva and expand and prolong, cause periodontal pocket to form and frontal resorption, cause periodontitis.

The symptom of periodontitis mainly shows as red swelling of gingiva, hemorrhage, and is not only hemorrhage when brushing teeth, and also hemorrhage when speaking or stinging hard thing sometimes, gingiva color is dark red, the comparison light because edema seems.In addition, also have periodontal pocket to form, under normal circumstances, to two millimeters, surpass two millimeters then is periodontal pocket to gingiva attached to the gingival sulcus on the tooth only dark zero.The formation explanation inflammation of periodontal pocket develops into the periodontal support tissue from gingiva, and the periodontal tissue than deep layer is infected, chronic destruction, and purulent secretion can overflow from periodontal pocket.Early stage periodontitis tooth is not loosening, only develops into certain degree at chronic destructive inflammation, when periodontal tissue's supporting strength greatly weakens, just can cause odontoseisis.Gingival recession also is one of symptom of periodontitis, but the patient often is difficult for discovering.The periodontitis that local factor causes owing to be subjected to the compressing of a large amount of tartar for a long time, stimulates gingiva, so shrinking back of horizontal appears in gum edge profile.Shrink back as for senile periodontal tissue, generally belong to physiological conditions.Be shrinking back on the one hand because of periodontal tissue itself; Be that abrasion owing to tooth make tooth continue eruption on the other hand, form the root of the tooth face and expose.Because the exposure of root of the tooth face to hot and cold, sweet, sour food or mechanical irritation, all has responsive performance.But the factor of also having plenty of physiology and pathology exists simultaneously.

Pre-preventing parodontitis should accomplish following some:

(1) grasps correct method for brushing teeth, every day 3 times, each 3 minutes;

(2) after meal, gargle before sleeping, keep oral cavity cleaning;

(3) food debris to being difficult for removing, soft dirt, bacterial plaque is used dental floss, toothpick, toothbrush cleaning;

(4) make regular check on scaling half a year 1 time on the gum.

The traditional Chinese medical science thinks that periodontitis belongs to categories such as " gum erosion ", " tooth very ", " tooth is newly declared dew ", " malnutrition due to wind "." disease of teeth has three cards: fire on the one, two day breezes were suffered from a deficiency of the kidney on the 3rd.The fiery patient of all genus must be sick between dental bed muscle, or for swelling and ache, or for swollen rotten to the corn, or be gingival hemorrhage, all disease is at meridians.Various focusing depths represented, hemorrhage, red and swollen, pain and halitosis are mostly by due to steaming on the stomach-fire, deficiency of kidney yin, outer the invading of burning hot evil poison.Tang Zonghai " treatise on blood trouble " thinks " mouthful be the door of stomach ", " dental bed particularly stomach passages through which vital energy circulates institute around, so the wind epistaxis all is a flaming up of stomach-fire, blood moves with fire ... ".And positive bright stomach warp under the upper tooth, positive bright large intestine channel under the lower tooth, how by damp and hot hold in Yang Ming harmony in network.This shows that cementopathia is relevant through excessiveness of stomach-fire with stomach.Bright " Jing Yue's complete work tooth door " said: " all fiery patients must be sick between dental bed muscle, or for swelling and ache, or be erosion, or be smelly dirty, comes off, or the teeth space haemophilia, be all disease at meridians ".The Jing-Yue Complete Works cloud: " renal failure then tooth is slitted, smart solid then tooth heavily fortified point ", " surgery great achievement " cloud: " ... mouth is not smelly, and tooth moves into dedentition ".The periodontal patient is long with the course of disease, and odontoseisis is aching and limp unable, even comes off, all by deficiency of kidney-essence, the withered tooth pine of kidney, the deficiency of YIN is hyperactivity of deficient fire then, then bleeding from the gum, halitosis, treatment increases body immunity when with kidney tonifying marrow facilitating, consolidate and radically reform, treating both the principal and secondary aspects of a disease, nourishing YIN to lower pathogenic fire are main, reach the purpose that teeth consolidating is protected gum.

The traditional Chinese medical science adopts rushes down clearly that stomach-fire, detumescence are dispeled the wind, this disease of decoction for the treatment of blood circulation promoting and blood stasis dispelling.

Summary of the invention

The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of periodontitis.

The present invention also aims to provide a kind of preparation method of this Chinese medicine composition.

In order to realize purpose of the present invention, the invention provides a kind of Chinese medicine composition for the treatment of periodontitis, be to make by effective ingredient and/or pharmaceutically acceptable carrier, described effective ingredient is made by weight by following raw materials according:

Radix Rehmanniae 10-20 part Cortex Lycii 5-10 part Fructus Litchi 15-25 part

Radix Rehmanniae Preparata 10-15 part 10-15 Radix Ophiopogonis part Flos Chrysanthemi 20-30 part

Radix Glycyrrhizae 15-25 part Radix Scrophulariae 5-10 part Radix Codonopsis 5-10 part

Rhizoma Anemarrhenae 10-20 part Radix Scutellariae 15-20 part Rhizoma Corydalis 15-25 part

Flos Sophorae Immaturus 20-25 part Radix Achyranthis Bidentatae 10-20 part

Effective ingredient is preferably made by weight by following raw materials according:

20 parts of 8 portions of Fructus Litchi of 16 parts of Cortex Lycii of the Radix Rehmanniae

26 parts of Radix Rehmanniae Preparata 13 parts of Flos Chrysanthemis, 13 parts of Radix Ophiopogonis

8 parts of 8 parts of Radix Codonopsis of 21 portions of Radix Scrophulariaes of Radix Glycyrrhizae

21 parts of 18 parts of Rhizoma Corydalis of 16 parts of Radix Scutellariaes of the Rhizoma Anemarrhenae

16 parts of 23 parts of Radix Achyranthis Bidentataes of the Flos Sophorae Immaturus

The present invention also provides a kind of preparation method of this Chinese medicine composition, comprises the steps:

(1) to be broken into impalpable powder standby for Radix Glycyrrhizae powder;

(2) Radix Rehmanniae, Radix Codonopsis, Rhizoma Corydalis are with 60% alcohol reflux secondary, and each one hour, gradation filtered, merging filtrate,

It is the clear paste of 1.15 (60 ℃) that concentrating under reduced pressure becomes relative density;

(3) Cortex Lycii, Fructus Litchi, Radix Rehmanniae Preparata, Radix Ophiopogonis, Flos Chrysanthemi, Radix Scrophulariae, the Rhizoma Anemarrhenae, Radix Scutellariae, the Flos Sophorae Immaturus, Radix Achyranthis Bidentatae decoct with water secondary, each 1 hour, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.

Pharmaceutical composition of the present invention can with receivable carrier pharmaceutically, for example: filler such as starch, microcrystalline Cellulose etc.; Binding agent such as vitamin derivative, starch etc.; Mode by granule, capsule, tablet oral administration is used.

Chinese medicine composition of the present invention has rushes down clearly that stomach-fire, detumescence are dispeled the wind, effect such as blood circulation promoting and blood stasis dispelling, is used for red swelling of gingiva that periodontitis causes, disease such as hemorrhage.

The specific embodiment

Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.

Embodiment 1: Chinese medicinal composition granules of the present invention

(1) to be ground into impalpable powder standby for Radix Glycyrrhizae 210g;

(2) Radix Rehmanniae 160g, Radix Codonopsis 80g, Rhizoma Corydalis 210g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Cortex Lycii 80g, Fructus Litchi 200g, Radix Rehmanniae Preparata 130g, Radix Ophiopogonis, 130g, Flos Chrysanthemi 260g, Radix Scrophulariae 80g, Rhizoma Anemarrhenae 160g, Radix Scutellariae 180g, Flos Sophorae Immaturus 230g, Radix Achyranthis Bidentatae 160g decocted with water secondary, each 1 hour, filtered, merging filtrate left standstill 48 hours, got supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned fine powder and clear paste, drying is ground into fine powder, add dextrin 900g, lactose 200g, mixing, with 73% ethanol wet granulation, pack promptly.

Embodiment 2: Chinese medicinal composition capsules agent of the present invention

(1) to be ground into impalpable powder standby for Radix Glycyrrhizae 210g;

(2) Radix Rehmanniae 160g, Radix Codonopsis 80g, Rhizoma Corydalis 210g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Cortex Lycii 80g, Fructus Litchi 200g, Radix Rehmanniae Preparata 130g, Radix Ophiopogonis, 130g, Flos Chrysanthemi 260g, Radix Scrophulariae 80g, Rhizoma Anemarrhenae 160g, Radix Scutellariae 180g, Flos Sophorae Immaturus 230g, Radix Achyranthis Bidentatae 160g decocted with water secondary, each 2 hours, filter merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, dry, be ground into fine powder, add dextrin 400g mixing, in the capsulae vacuus of packing into promptly.

Embodiment 3: Chinese medicine composition tablet of the present invention

(1) to be ground into impalpable powder standby for Radix Glycyrrhizae 210g;

(2) Radix Rehmanniae 160g, Radix Codonopsis 80g, Rhizoma Corydalis 210g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Cortex Lycii 80g, Fructus Litchi 200g, Radix Rehmanniae Preparata 130g, Radix Ophiopogonis, 130g, Flos Chrysanthemi 260g, Radix Scrophulariae 80g, Rhizoma Anemarrhenae 160g, Radix Scutellariae 180g, Flos Sophorae Immaturus 230g, Radix Achyranthis Bidentatae 160g decocted with water secondary, each 2 hours, filtered, merging filtrate left standstill 48 hours, got supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned fine powder and clear paste, drying is ground into fine powder, add starch 300g, carboxymethylstach sodium 50g is with 70% ethanol wet granulation, and tabletting, coating are promptly.

Claims (4)

1, a kind of Chinese medicine composition for the treatment of periodontitis is to be made by effective ingredient and/or pharmaceutically acceptable carrier, it is characterized in that described effective ingredient is made by weight by following raw materials according.

Radix Rehmanniae 10-20 part Cortex Lycii 5-10 part Fructus Litchi 15-25 part

Radix Rehmanniae Preparata 10-15 part 10-15 Radix Ophiopogonis part Flos Chrysanthemi 20-30 part

Radix Glycyrrhizae 15-25 part Radix Scrophulariae 5-10 part Radix Codonopsis 5-10 part

Rhizoma Anemarrhenae 10-20 part Radix Scutellariae 15-20 part Rhizoma Corydalis 15-25 part

Flos Sophorae Immaturus 20-25 part Radix Achyranthis Bidentatae 10-20 part.

2, Chinese medicine composition as claimed in claim 1 is characterized in that described effective ingredient made by weight by following raw materials according.

20 parts of 8 portions of Fructus Litchi of 16 parts of Cortex Lycii of the Radix Rehmanniae

26 parts of Radix Rehmanniae Preparata 13 parts of Flos Chrysanthemis, 13 parts of Radix Ophiopogonis

8 parts of 8 parts of Radix Codonopsis of 21 portions of Radix Scrophulariaes of Radix Glycyrrhizae

21 parts of 18 parts of Rhizoma Corydalis of 16 parts of Radix Scutellariaes of the Rhizoma Anemarrhenae

16 parts of 23 parts of Radix Achyranthis Bidentataes of the Flos Sophorae Immaturus.

3,, it is characterized in that described Chinese medicine composition can be made into granule, capsule and tablet as the arbitrary described Chinese medicine composition of claim 1-2.

4, a kind of preparation method as the arbitrary described Chinese medicine composition of claim 1-3 comprises the steps:

(1) to be broken into impalpable powder standby for Radix Glycyrrhizae powder;

(2) Radix Rehmanniae, Radix Codonopsis, Rhizoma Corydalis are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Cortex Lycii, Fructus Litchi, Radix Rehmanniae Preparata, Radix Ophiopogonis, Flos Chrysanthemi, Radix Scrophulariae, the Rhizoma Anemarrhenae, Radix Scutellariae, the Flos Sophorae Immaturus, Radix Achyranthis Bidentatae decoct with water secondary, each 1 hour, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.