CN110075036A - Anti- oral helicobacter pylori medicated toothpaste - Google Patents
Anti- oral helicobacter pylori medicated toothpaste Download PDFInfo
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- CN110075036A CN110075036A CN201910519481.XA CN201910519481A CN110075036A CN 110075036 A CN110075036 A CN 110075036A CN 201910519481 A CN201910519481 A CN 201910519481A CN 110075036 A CN110075036 A CN 110075036A
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses a kind of anti-oral helicobacter pylori medicated toothpaste and preparation method thereof, the anti-oral helicobacter pylori medicated toothpaste includes following raw materials: hydrated silica, sodium carboxymethylcellulose, lauryl alcohol sodium sulfovinate, sorbierite, glycerol, saccharin sodium, olibanum, lactoferrin, Honegsukle flower P.E, coptis extract, houttuynia extract, sodium benzoate, pure water, Peppermint essential oil, essence.The invention has the benefit that each raw material of anti-oral helicobacter pylori medicated toothpaste of the present invention is combined together, helicobacter pylori is set to lose the environment of existence in the oral cavity, and it is killed by natural disinfection drug, health, safety, prevent that illness finds its way in by the mouth, the environment in oral cavity will not be destroyed, the generation of stomach trouble is fundamentally prevented.
Description
Technical field
The present invention relates to articles for daily use technical fields, and in particular to a kind of anti-oral helicobacter pylori medicated toothpaste and its system
Preparation Method.
Background technique
Toothpaste is common cleaning supplies in daily life, is a kind of dentifrice, generally in as a form of gel, it will usually be put on tooth
It paints, for cleaning tooth, beautiful teeth and whitening is kept to have long history.It and toothbrush play removing together and remove tooth
Tooth dirt, swill, the effect for protecting gum.
Oral helicobacter pylori is a kind of stomach bacterium, can trigger disease of stomach, can often cause chronic gastroenteropathy
And gastric ulcer, if taking measures to be treated not in time, it is also possible to malignant change occur, induce cancer.Helicobacter pylori
This germ mainly enters from oral cavity, stomach lactation madness will be stimulated to secrete once catching helicobacter pylori, to cause stomach
The symptoms such as acid, stomachache, heartburn；Helicobacter pylori also results in patient and the phenomenon that pain occurs, and patients whose symptoms were less severe are that interval is ached, and
Symptom can be with violent colic pain compared with severe one, and understands recurrent exerbation.Since helicobacter pylori can cause much in inside of human body
Urine poison bacterium, can be evaporated from mouth, so as to cause intractable halitosis occurs, and as the latent of helicobacter pylori is led
Aggravation is caused, to can cause vomiting, the chronic gastroenteropathies illness such as diarrhea.
Because helicobacter pylori can take root oral cavity is resident, therefore noted that oral hygiene, prevents that illness finds its way in by the mouth, increasingly become
Prevent helicobacter pylori infections, prevents the important measures of stomach trouble and gastric cancer.It is same using large dosage of Multiple Classes of Antibiotics in the prior art
When take and kill helicobacter pylori, but cannot thoroughly kill helicobacter pylori in this way, will increase its drug resistance instead, easily lead to
Disease recurrent exerbation increases the difficulty for the treatment of.
Toothpaste is the necessary supply that people clear up oral cavity daily, and existing toothpaste has cleaning oral cavity more, kills the work of bacterium
With, but the existing toothpaste with sterilizing function, some addition antibiotic, disinfectant, while harmful bacteria is killed, it would be beneficial to
Bacterium also kills, and destroys Oral health behaviours environment, increases the drug resistance of bacterium, therefore one kind is resistant to oral helicobacter pylori
And healthy and safe toothpaste becomes the demand in market.
Summary of the invention
Oral helicobacter pylori can be thoroughly killed the object of the present invention is to provide a kind of, improves oral environment, prevents stomach trouble
The anti-oral helicobacter pylori medicated toothpaste and preparation method thereof occurred.
A kind of anti-oral helicobacter pylori medicated toothpaste, including component A, B component, component C；
The component A is made of the raw material of following weight parts: 20-40 parts of hydrated silica, sodium carboxymethylcellulose 1-5
Part, 3-5 parts of lauryl alcohol sodium sulfovinate；
The B component is made of the raw material of following weight parts: 10-60 parts of sorbierite, 5-10 parts of glycerol, saccharin sodium
0.14-0.16 parts, 1-5 parts of olibanum, 0.1-0.5 parts of lactoferrin, 0.1-1 parts of Honegsukle flower P.E, coptis extract
0.1-1 parts, 0.1-1 parts of houttuynia extract, 0.1-0.25 parts of sodium benzoate, 10-20 parts of pure water；
The component C is made of the raw material of following weight parts: 1-3 parts of Peppermint essential oil, 0.1-0.5 parts of essence.
Further, the anti-oral helicobacter pylori medicated toothpaste, including component A, B component, component C:
The component A is made of the raw material of following weight parts: 25-35 parts of hydrated silica, sodium carboxymethylcellulose 3-4
Part, 4-5 parts of lauryl alcohol sodium sulfovinate；
The B component is made of the raw material of following weight parts: 30-40 parts of sorbierite, 6-8 parts of glycerol, saccharin sodium
0.14-0.15 parts, 2-3 parts of olibanum, 0.2-0.4 parts of lactoferrin, 0.5-0.8 parts of Honegsukle flower P.E, coptis extract
0.6-0.8 parts, 0.6-0.8 parts of houttuynia extract, 0.1-0.2 parts of sodium benzoate, 12-16 parts of pure water；
The component C is made of the raw material of following weight parts: 1-2 parts of Peppermint essential oil, 0.2-0.4 parts of essence.
Further, the anti-oral helicobacter pylori medicated toothpaste, including component A, B component, component C；
The component A is made of the raw material of following weight parts: 30 parts of hydrated silica, 3 parts of sodium carboxymethylcellulose, lauryl alcohol
4 parts of sodium sulfovinate；
The B component is made of the raw material of following weight parts: 30 parts of sorbierite, 7 parts of glycerol, 0.15 part of saccharin sodium, olibanum 3
Part, 0.3 part of lactoferrin, 0.6 part of Honegsukle flower P.E, 0.6 part of coptis extract, 0.6 part of houttuynia extract, sodium benzoate
0.15 part, 15 parts of pure water；
The component C is made of the raw material of following weight parts: 2 parts of Peppermint essential oil, 0.3 part of essence.
Contained olibanum can effectively kill the periodontal germ in oral cavity in anti-oral helicobacter pylori medicated toothpaste of the present invention
And helicobacter pylori, and fragrance can be given out, lactoferrin can be in conjunction with the iron ion that helicobacter pylori depends on for existence, to hinder
Break its nutrient source, reduces the absorption of its necessary element this to iron, achievees the purpose that inhibit growth of H. pylori, and the coptis has
There is the effect of heat-clearing and damp-drying drug, purging fire for removing toxin, is able to maintain intraoral cleaning；And Honegsukle flower P.E has one to various pathogens
Fixed inhibiting effect, and the immunity of body can be reinforced, cordate houttuynia also has certain inhibiting effect, and energy to various pathogens
Stomach strengthening and digestion promoting, i.e. these raw materials are combined together, and can be killed the helicobacter pylori in oral cavity, be made helicobacter pylori in the oral cavity
It loses the environment of existence, and is killed by natural disinfection drug, prevent that illness finds its way in by the mouth, the environment in oral cavity will not be destroyed,
The generation for preventing stomach trouble.
Peppermint essential oil is the ingredient that peppermint goes out by water distillation or subcritical low-temperature extraction, has throat-clearing throat-moistening, eliminates mouth
It is smelly, the curative effect for body and mind of releiving.The refrigerant attribute of peppermint can pacify indignation, hysteria and frightened state, give free heart
Unfold space.
Silica is in chemical inertness, and good with Fluoride in Toothpaste compound and other materials compatibilities, compatibility is good, is rubbed with it
Toothpaste made of liniment, lotion is fine and smooth, mouthfeel is smooth, paste stability is relatively good, while not damage tooth again, to improving lotion
Institutional framework and appearance reached satisfactory effect.
Sodium carboxymethylcellulose is that use scope is most wide in the world today, the maximum cellulose type of dosage, in toothpaste
In be wetting excipient be adhesive again, can play the role of protecting cream base moisture, keep cream base rheological characteristic and thixotropic, guarantor
The effect for holding cream base stability emulsifies solid phase powder and liquid homogenizing, becomes stable suspension.
Sorbierite and glycerol are used as moisturizer in toothpaste.
Lactoferrin is a kind of important nonheme iron combination glycoprotein in milk, has in neutrophil leucocyte particle and kills
The active monomeric glycoprotein of bacterium is not only involved in the transhipment of iron, and has broad-spectrum antiseptic, anti-oxidant, anticancer, adjusts immune system
Etc. powerful biological function, it is adjustable the balance of internal iron, adjusts the generation of bone marrow cell, promotes the growth of cell, adjusts body
Immune function, irony needed for bacterial growth can be seized and inhibit the growth of bacterium or destroy bacterial cell membrane to reach kill thin
The effect of bacterium.
Lactoferrin has the activity of anti-helicobacter pylori in vivo and in vitro, can depend on for existence in conjunction with helicobacter pylori
Iron ion reduces the absorption of its necessary element this to iron to block its nutrient source, reaches and inhibits growth of H. pylori
Purpose, it is effective in cure to gastritis caused by it, gastric ulcer and cancer, and will not develop drug resistance.
Honegsukle flower P.E also known as honeysuckle (scientific name: Lonicera japonica), property is sweet, slight bitter, Honegsukle flower P.E pair
Various pathogens for example staphylococcus aureus, hemolytic streptococcus, Escherichia coli, shigella dysenteriae, comma bacillus, typhoid bacillus,
Paratyphosum Bacterium etc. has certain inhibiting effect, and Honegsukle flower P.E also has the function of booster immunization function, can promote white thin
The phagocytic function of born of the same parents and inflammatory cell.Furthermore Honegsukle flower P.E contains the necessary microelement of human body and chemical component, simultaneously
Containing there are many to the advantageous active enzyme material of human body, there is anti-aging, anti-canceration, the good effects being healthy and strong of making light of one's life by commiting suicide.
Coptis extract has effects that heat-clearing and damp-drying drug, purging fire for removing toxin, is commonly used to treat damp and hot feeling of fullness, vomits acid regurgitation, the heart
It is tired to be insomnia, hot eyes, toothache etc..Additionally there is antibacterial, antitumor and antiarrhythmic pharmacological activity can inhibit influenza virus
With hepatitis B etc..
Houttuynia extract is the herbal medicine that Chinese Pharmacopoeia is included, herbal medicine source be saururaceae plant houttuynia cordata (Classification system:
Houttuyniacordata Thunb.) dry aerial parts, it is acrid flavour, cold, there is clearing heat and detoxicating, detumescence to treat sore, benefit
The effect of urinating dehumidifying, clearing away heat to cure dysentery, stomach strengthening and digestion promoting, furthermore houttuynia extract also has antibacterial, antiviral, raising immunity of organism
The effect of power and diuresis.The phagocytic activity of WBC can be enhanced in houttuynia extract, improves serum properdin, houttuynia extract
The immunity that body can be improved has great significance to the treatment of venereal infection.The one kind raised in houttuynia extract
Yellow oil has inhibiting effect to various microorganisms (especially saccharomycete and mould), to hemolytic streptococcus, golden yellow
Staphylococcus, Bacillus influenzae, micrococcus catarrhalis, pneumococcus have apparent inhibiting effect.
Sodium benzoate is a kind of white particle or crystal powder, odorless, is broad spectrum antimicrobial microbial inoculum, makes as preservative
With.
Olibanum is olive subject plant Boswellia carterii and the resin that congener bark oozes out, and can give out the smell of faint scent, also
The growth of bacterium can effectively be inhibited, can effectively kill the periodontal germ and helicobacter pylori in oral cavity.
Lauryl alcohol sodium sulfovinate is the synthetic surfactant of Petroleum refining, is a kind of cheap detergent.
Saccharin sodium is common synthetic sweetener in food industry；Hydrated silica is also referred to as pure latex, hydrated SiO 2, white
Carbon black, silicic acid hydrate have preferable wearing coefficient.
The preparation method of the anti-oral helicobacter pylori medicated toothpaste, comprising the following steps:
(1) each raw material of B component is mixed evenly, obtains mixed liquor；
(2) component A is added into mixed liquor, is mixed evenly, and carries out emulsification treatment, obtains paste；
(3) component C is added into paste, is mixed evenly, carries out homogenization, vacuumize the anti-oral cavity is deep and remote
Helicobacter pylori medicated toothpaste.
Further, in step (1), by each raw material of B component 50-60 DEG C at a temperature of, with 50-80r/min's
Mixing speed is mixed evenly.
Further, in step (2), the temperature of mixed liquor is down to 30-40 DEG C, then component A is added into mixed liquor.
Further, in step (2), the temperature of the emulsification treatment is 70-80 DEG C.
Further, in step (3), the homogeneous is homogeneous 3- under conditions of revolving speed is 1000-2000r/min
5min。
Further, in step (3), the homogeneous is homogeneous 4min under conditions of revolving speed is 1500r/min.
Further, described to vacuumize to carry out vacuumize process in vacuum tank in step (3).
The invention has the benefit that contained olibanum can be effective in anti-oral helicobacter pylori medicated toothpaste of the present invention
The periodontal germ and helicobacter pylori in oral cavity are killed, and fragrance can be given out, lactoferrin can rely in conjunction with helicobacter pylori
The iron ion of existence reduces the absorption of its necessary element this to iron to block its nutrient source, reaches and inhibits helicobacter pylori
The purpose of growth, and the coptis has effects that heat-clearing and damp-drying drug, purging fire for removing toxin, is able to maintain intraoral cleaning；And honeysuckle is extracted
Object has certain inhibiting effect to various pathogens, and can reinforce the immunity of body, and cordate houttuynia also has various pathogens
There is certain inhibiting effect, and energy stomach strengthening and digestion promoting, i.e. these raw materials are combined together, and helicobacter pylori is made to lose life in the oral cavity
The environment deposited, and being killed by natural disinfection drug, health, safety, prevents that illness finds its way in by the mouth, will not destroy the ring in oral cavity
The generation of stomach trouble is fundamentally prevented in border.
Antibiotic composition is not contained in anti-oral helicobacter pylori medicated toothpaste of the present invention, uses natural Chinese medicine
Raw material kills the helicobacter pylori and other bacteriums in mouth, and is able to maintain breath freshening, uses anti-oral cavity pylorus of the present invention
Helicobacter medicated toothpaste can thoroughly kill the helicobacter pylori in oral cavity, helicobacter pylori will not be made to develop drug resistance, and will not
Destroy the microenvironment in oral cavity.
Specific embodiment
Embodiment 1
A kind of anti-oral helicobacter pylori medicated toothpaste, including component A, B component, component C；
The component A is made of the raw material of following weight parts: hydrated silica 20kg, sodium carboxymethylcellulose 1kg, lauryl alcohol
Sodium sulfovinate 3kg；
The B component is made of the raw material of following weight parts: sorbierite 10kg, glycerol 5kg, saccharin sodium 0.14kg, olibanum
1kg, lactoferrin 0.1kg, Honegsukle flower P.E 0.1kg, coptis extract 0.1kg, houttuynia extract 0.1kg, benzoic acid
Sodium 0.1kg, pure water 10kg；
The component C is made of the raw material of following weight parts: Peppermint essential oil 1kg, essence 0.1kg.
The preparation method of the anti-oral helicobacter pylori medicated toothpaste, comprising the following steps:
(1) each raw material of B component is mixed evenly, obtains mixed liquor；
(2) component A is added into mixed liquor, is mixed evenly, and carries out emulsification treatment, obtains paste；
(3) component C is added into paste, is mixed evenly, carries out homogenization, vacuumize the anti-oral cavity is deep and remote
Helicobacter pylori medicated toothpaste.
Embodiment 2
A kind of anti-oral helicobacter pylori medicated toothpaste, including component A, B component, component C；
The component A is made of the raw material of following weight parts: hydrated silica 25kg, sodium carboxymethylcellulose 3kg, lauryl alcohol
Sodium sulfovinate 4kg；
The B component is made of the raw material of following weight parts: sorbierite 30kg, glycerol 6kg, saccharin sodium 0.14kg, olibanum
2kg, lactoferrin 0.2kg, Honegsukle flower P.E 0.5kg, coptis extract 0.6kg, houttuynia extract 0.6kg, benzoic acid
Sodium 0.1kg, pure water 12kg；
The component C is made of the raw material of following weight parts: Peppermint essential oil 1kg, essence 0.2kg.
The preparation method of the anti-oral helicobacter pylori medicated toothpaste, comprising the following steps:
(1) by each raw material of B component 50 DEG C at a temperature of, be mixed evenly, obtained mixed with the mixing speed of 50r/min
Close liquid；
(2) temperature of mixed liquor is down to 30 DEG C, component A is added into mixed liquor, be mixed evenly, be 70 in temperature
Emulsification treatment is carried out under conditions of DEG C, obtains paste；
(3) component C is added into paste, is mixed evenly, homogenization under conditions of revolving speed is 1000r/min
Then 3min vacuumizes to obtain the anti-oral helicobacter pylori medicated toothpaste in vacuum tank.
Embodiment 3
A kind of anti-oral helicobacter pylori medicated toothpaste, including component A, B component, component C；
The component A is made of the raw material of following weight parts: hydrated silica 30kg, sodium carboxymethylcellulose 3kg, lauryl alcohol
Sodium sulfovinate 4kg；
The B component is made of the raw material of following weight parts: sorbierite 30kg, glycerol 7kg, saccharin sodium 0.15kg, olibanum
3kg, lactoferrin 0.3kg, Honegsukle flower P.E 0.6kg, coptis extract 0.6kg, houttuynia extract 0.6kg, benzoic acid
Sodium 0.15kg, pure water 15kg；
The component C is made of the raw material of following weight parts: Peppermint essential oil 2kg, essence 0.3kg.
The preparation method of the anti-oral helicobacter pylori medicated toothpaste, comprising the following steps:
(1) by each raw material of B component 55 DEG C at a temperature of, be mixed evenly, obtained mixed with the mixing speed of 60r/min
Close liquid；
(2) temperature of mixed liquor is down to 32 DEG C, component A is added into mixed liquor, be mixed evenly, be 75 in temperature
Emulsification treatment is carried out under conditions of DEG C, obtains paste；
(3) component C is added into paste, is mixed evenly, homogenization under conditions of revolving speed is 1200r/min
Then 4min vacuumizes to obtain the anti-oral helicobacter pylori medicated toothpaste in vacuum tank.
Embodiment 4
A kind of anti-oral helicobacter pylori medicated toothpaste, including component A, B component, component C；
The component A is made of the raw material of following weight parts: hydrated silica 35kg, sodium carboxymethylcellulose 4kg, lauryl alcohol
Sodium sulfovinate 5kg；
The B component is made of the raw material of following weight parts: sorbierite 40kg, glycerol 8kg, saccharin sodium 0.15kg, olibanum
3kg, lactoferrin 0.4kg, Honegsukle flower P.E 0.8kg, coptis extract 0.8kg, houttuynia extract 0.8kg, benzoic acid
Sodium 0.2kg, pure water 16kg；
The component C is made of the raw material of following weight parts: Peppermint essential oil 2kg, essence 0.4kg.
The preparation method of the anti-oral helicobacter pylori medicated toothpaste, comprising the following steps:
(1) by each raw material of B component 58 DEG C at a temperature of, be mixed evenly, obtained mixed with the mixing speed of 70r/min
Close liquid；
(2) temperature of mixed liquor is down to 38 DEG C, component A is added into mixed liquor, be mixed evenly, be 78 in temperature
Emulsification treatment is carried out under conditions of DEG C, obtains paste；
(3) component C is added into paste, is mixed evenly, homogenization under conditions of revolving speed is 1800r/min
Then 4min vacuumizes to obtain the anti-oral helicobacter pylori medicated toothpaste in vacuum tank.
Embodiment 5
A kind of anti-oral helicobacter pylori medicated toothpaste, including component A, B component, component C；
The component A is made of the raw material of following weight parts: hydrated silica 40kg, sodium carboxymethylcellulose 5kg, lauryl alcohol
Sodium sulfovinate 5kg；
The B component is made of the raw material of following weight parts: sorbierite 60kg, glycerol 10kg, saccharin sodium 0.16kg, olibanum
5kg, lactoferrin 0.5kg, Honegsukle flower P.E 1kg, coptis extract 1kg, houttuynia extract 1kg, sodium benzoate
0.25kg, pure water 20kg；
The component C is made of the raw material of following weight parts: Peppermint essential oil 3kg, essence 0.5kg.
The preparation method of the anti-oral helicobacter pylori medicated toothpaste, comprising the following steps:
(1) by each raw material of B component 60 DEG C at a temperature of, be mixed evenly, obtained mixed with the mixing speed of 80r/min
Close liquid；
(2) temperature of mixed liquor is down to 40 DEG C, component A is added into mixed liquor, be mixed evenly, be 80 in temperature
Emulsification treatment is carried out under conditions of DEG C, obtains paste；
(3) component C is added into paste, is mixed evenly, homogenization under conditions of revolving speed is 2000r/min
Then 5min vacuumizes to obtain the anti-oral helicobacter pylori medicated toothpaste in vacuum tank.
Comparative example 1
Anti- oral helicobacter pylori medicated toothpaste described in comparative example 1, including component A, B component, component C:
The component A is made of the raw material of following weight parts: hydrated silica 30kg, sodium carboxymethylcellulose 3kg, lauryl alcohol
Sodium sulfovinate 4kg；
The B component is made of the raw material of following weight parts: sorbierite 30kg, glycerol 7kg, saccharin sodium 0.15kg, newborn iron
Albumen 0.3kg, Honegsukle flower P.E 0.6kg, coptis extract 0.6kg, houttuynia extract 0.6kg, sodium benzoate 0.15kg,
Pure water 15kg；
The component C is made of the raw material of following weight parts: Peppermint essential oil 2kg, essence 0.3kg.
The preparation method of anti-oral helicobacter pylori medicated toothpaste described in comparative example 1 and anti-oral cavity pylorus spiral shell of the present invention
The preparation method of bacillus medicated toothpaste is identical.
Comparative example 2
Anti- oral helicobacter pylori medicated toothpaste described in comparative example 2, including component A, B component, component C:
The component A is made of the raw material of following weight parts: hydrated silica 30kg, sodium carboxymethylcellulose 3kg, lauryl alcohol
Sodium sulfovinate 4kg；
The B component is made of the raw material of following weight parts: sorbierite 30kg, glycerol 7kg, saccharin sodium 0.15kg, gold and silver
Flower extract 0.6kg, coptis extract 0.6kg, houttuynia extract 0.6kg, sodium benzoate 0.15kg, pure water 15kg；
The component C is made of the raw material of following weight parts: Peppermint essential oil 2kg, essence 0.3kg.
The preparation method of anti-oral helicobacter pylori medicated toothpaste described in comparative example 2 and anti-oral cavity pylorus spiral shell of the present invention
The preparation method of bacillus medicated toothpaste is identical.
Comparative example 3
Anti- oral helicobacter pylori medicated toothpaste described in comparative example 3, including component A, B component, component C:
The component A is made of the raw material of following weight parts: hydrated silica 30kg, sodium carboxymethylcellulose 3kg, lauryl alcohol
Sodium sulfovinate 4kg；
The B component is made of the raw material of following weight parts: sorbierite 30kg, glycerol 7kg, saccharin sodium 0.15kg, olibanum
3kg, lactoferrin 0.3kg, sodium benzoate 0.15kg, pure water 15kg；
The component C is made of the raw material of following weight parts: Peppermint essential oil 2kg, essence 0.3kg.
The preparation method of anti-oral helicobacter pylori medicated toothpaste described in comparative example 3 and anti-oral cavity pylorus spiral shell of the present invention
The preparation method of bacillus medicated toothpaste is identical.
Anti- oral helicobacter pylori drug tooth described in anti-oral helicobacter pylori medicated toothpaste of the present invention and comparative example
Effect disquisition of the cream in terms of anti-oral helicobacter pylori:
The helicobacter pylori of 37 DEG C of cultures for 24 hours is mixed with physiological saline, mixed liquor bacterial content is made to reach 105cfu/ml；
It takes 0.1ml bacterium solution to be uniformly coated on beef extract protein solid culture medium, takes anti-oral cavity described in 1-5 of the embodiment of the present invention respectively
Anti-Heliobactorpylori drug toothpaste medical fluid, anti-oral helicobacter pylori medicated toothpaste medical fluid described in comparative example 1-3, sterile water-soaked
Diameter is the aseptic filter paper piece of 6mm, and filter paper is placed on and is applied on bacterium culture medium, sets 37 DEG C of cultures for 24 hours, observes antibacterial circle diameter,
The bacteriostasis of judgement sample；Bacteriostatic experiment is repeated 3 times, and antibacterial result is 3 laboratory mean values, and the results are shown in Table 1:
Table 1
As can be seen from Table 1: anti-oral helicobacter pylori medicated toothpaste of the present invention has apparent anti-helicobacter pylorus
The effect of bacterium can thoroughly kill helicobacter pylori；Comparative example 1 is relative to anti-oral helicobacter pylori drug tooth of the present invention
Cream has lacked olibanum in raw material, and the effect for killing helicobacter pylori accordingly decreases；Documents 2 are relative to of the present invention
Anti- oral helicobacter pylori medicated toothpaste has lacked olibanum and lactoferrin in raw material, and bactericidal effect is substantially reduced；Comparison text
Part 3 has lacked Honegsukle flower P.E, the coptis is extracted relative to anti-oral helicobacter pylori medicated toothpaste of the present invention in raw material
Object, houttuynia extract kill equal effect and decrease, it is seen that Honegsukle flower P.E, coptis extract, houttuynia extract exist
The effect of its assisting sterilisation in anti-oral helicobacter pylori medicated toothpaste of the present invention, and olibanum, lactoferrin are the present invention
The major antibacterial ingredient of the anti-oral helicobacter pylori medicated toothpaste, and olibanum and lactoferrin embody complementary kill
Bacterium effect.Remarks: "+" indicates that the speed degree of bacterial reproduction, "+" number more multilist show the faster of bacterial reproduction.
The present invention is not limited to above-mentioned preferred forms, anyone can show that other are various under the inspiration of the present invention
The product of form, however, make any variation in its details, it is all that there is technical solution identical or similar to the present application,
It is within the scope of the present invention.
Claims (10)
1. a kind of anti-oral helicobacter pylori medicated toothpaste, which is characterized in that including component A, B component, component C；
The component A is made of the raw material of following weight parts: 20-40 parts of hydrated silica, 1-5 parts of sodium carboxymethylcellulose, ten
3-5 parts of diol sulphates sodium；
The B component is made of the raw material of following weight parts: 10-60 parts of sorbierite, 5-10 parts of glycerol, saccharin sodium 0.14-
0.16 part, 1-5 parts of olibanum, 0.1-0.5 parts of lactoferrin, 0.1-1 parts of Honegsukle flower P.E, 0.1-1 parts of coptis extract,
0.1-1 parts of houttuynia extract, 0.1-0.25 parts of sodium benzoate, 10-20 parts of pure water；
The component C is made of the raw material of following weight parts: 1-3 parts of Peppermint essential oil, 0.1-0.5 parts of essence.
2. a kind of anti-oral helicobacter pylori medicated toothpaste according to claim 1, which is characterized in that including component A, B group
Divide, component C；
The component A is made of the raw material of following weight parts: 25-35 parts of hydrated silica, 3-4 parts of sodium carboxymethylcellulose, ten
4-5 parts of diol sulphates sodium；
The B component is made of the raw material of following weight parts: 30-40 parts of sorbierite, 6-8 parts of glycerol, saccharin sodium 0.14-
0.15 part, 2-3 parts of olibanum, 0.2-0.4 parts of lactoferrin, 0.5-0.8 parts of Honegsukle flower P.E, coptis extract 0.6-
0.8 part, 0.6-0.8 parts of houttuynia extract, 0.1-0.2 parts of sodium benzoate, 12-16 parts of pure water；
The component C is made of the raw material of following weight parts: 1-2 parts of Peppermint essential oil, 0.2-0.4 parts of essence.
3. a kind of anti-oral helicobacter pylori medicated toothpaste according to claim 1, which is characterized in that including component A, B group
Divide, component C；
The component A is made of the raw material of following weight parts: 30 parts of hydrated silica, 3 parts of sodium carboxymethylcellulose, lauryl alcohol sulfuric acid
4 parts of ester sodium；
The B component is made of the raw material of following weight parts: 30 parts of sorbierite, 7 parts of glycerol, 0.15 part of saccharin sodium, 3 parts of olibanum,
0.3 part of lactoferrin, 0.6 part of Honegsukle flower P.E, 0.6 part of coptis extract, 0.6 part of houttuynia extract, sodium benzoate
0.15 part, 15 parts of pure water；
The component C is made of the raw material of following weight parts: 2 parts of Peppermint essential oil, 0.3 part of essence.
4. the preparation method of anti-oral helicobacter pylori medicated toothpaste described in one of claim 1-3, which is characterized in that including
Following steps:
(1) each raw material of B component is mixed evenly, obtains mixed liquor；
(2) component A is added into mixed liquor, is mixed evenly, and carries out emulsification treatment, obtains paste；
(3) component C is added into paste, is mixed evenly, carries out homogenization, vacuumizes to obtain the anti-oral cavity pylorus spiral shell
Bacillus medicated toothpaste.
5. the preparation method of anti-oral helicobacter pylori medicated toothpaste according to claim 4, which is characterized in that step (1)
In, by each raw material of B component 50-60 DEG C at a temperature of, be mixed evenly with the mixing speed of 50-80r/min.
6. the preparation method of anti-oral helicobacter pylori medicated toothpaste according to claim 4, which is characterized in that step (2)
In, the temperature of mixed liquor is down to 30-40 DEG C, then component A is added into mixed liquor.
7. the preparation method of anti-oral helicobacter pylori medicated toothpaste according to claim 4, which is characterized in that step (2)
In, the temperature of the emulsification treatment is 70-80 DEG C.
8. the preparation method of anti-oral helicobacter pylori medicated toothpaste according to claim 4, which is characterized in that step (3)
In, the homogeneous is homogeneous 3-5min under conditions of revolving speed is 1000-2000r/min.
9. the preparation method of anti-oral helicobacter pylori medicated toothpaste according to claim 4, which is characterized in that step (3)
In, the homogeneous is homogeneous 4min under conditions of revolving speed is 1500r/min.
10. the preparation method of anti-oral helicobacter pylori medicated toothpaste according to claim 4, which is characterized in that step (3)
In, it is described to vacuumize to carry out vacuumize process in vacuum tank.
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| CN110507583A (en) * | 2019-09-27 | 2019-11-29 | 江苏协合转化医学研究院有限公司 | A kind of efficient prevention and control helicobacter pylori fresh breath toothpaste and preparation method thereof |
| CN110613631A (en) * | 2019-10-28 | 2019-12-27 | 青岛明月海藻生物健康科技集团有限公司 | Fucoidin delicate antibacterial composition for oral care products |
| CN111000752A (en) * | 2020-01-06 | 2020-04-14 | 陕西润和堂医药有限公司 | Traditional Chinese medicine toothpaste for resisting helicobacter pylori |
| CN111544319A (en) * | 2020-04-27 | 2020-08-18 | 江苏宝芝林多抗生物工程技术研究有限公司 | Toothpaste capable of inhibiting helicobacter pylori and preparation method thereof |
| CN111616996A (en) * | 2020-05-08 | 2020-09-04 | 广东立爽生物科技有限公司 | Helicobacter pylori-resistant toothpaste and preparation method thereof |
| CN111643393A (en) * | 2020-07-13 | 2020-09-11 | 幽汰(福建)大健康产业有限公司 | Oral toothpaste for inhibiting helicobacter pylori and preparation device thereof |
| CN111759773A (en) * | 2020-08-13 | 2020-10-13 | 福州幽力克生物科技有限公司 | Toothpaste capable of inhibiting helicobacter pylori and preparation method thereof |
| CN111888323A (en) * | 2020-08-25 | 2020-11-06 | 王祥 | Oral bacteriostatic cream for children and preparation method thereof |
| CN111904886A (en) * | 2020-07-27 | 2020-11-10 | 王祥 | Oral cavity antibacterial cream and preparation method thereof |
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| CN110507583A (en) * | 2019-09-27 | 2019-11-29 | 江苏协合转化医学研究院有限公司 | A kind of efficient prevention and control helicobacter pylori fresh breath toothpaste and preparation method thereof |
| CN110613631A (en) * | 2019-10-28 | 2019-12-27 | 青岛明月海藻生物健康科技集团有限公司 | Fucoidin delicate antibacterial composition for oral care products |
| CN111000752A (en) * | 2020-01-06 | 2020-04-14 | 陕西润和堂医药有限公司 | Traditional Chinese medicine toothpaste for resisting helicobacter pylori |
| CN111544319A (en) * | 2020-04-27 | 2020-08-18 | 江苏宝芝林多抗生物工程技术研究有限公司 | Toothpaste capable of inhibiting helicobacter pylori and preparation method thereof |
| CN111616996A (en) * | 2020-05-08 | 2020-09-04 | 广东立爽生物科技有限公司 | Helicobacter pylori-resistant toothpaste and preparation method thereof |
| CN111643393A (en) * | 2020-07-13 | 2020-09-11 | 幽汰(福建)大健康产业有限公司 | Oral toothpaste for inhibiting helicobacter pylori and preparation device thereof |
| CN111643393B (en) * | 2020-07-13 | 2022-06-28 | 幽汰(福建)大健康产业有限公司 | Oral helicobacter pylori inhibition toothpaste and preparation device thereof |
| CN111904886A (en) * | 2020-07-27 | 2020-11-10 | 王祥 | Oral cavity antibacterial cream and preparation method thereof |
| CN111759773A (en) * | 2020-08-13 | 2020-10-13 | 福州幽力克生物科技有限公司 | Toothpaste capable of inhibiting helicobacter pylori and preparation method thereof |
| CN111888323A (en) * | 2020-08-25 | 2020-11-06 | 王祥 | Oral bacteriostatic cream for children and preparation method thereof |
| CN112316123A (en) * | 2020-12-03 | 2021-02-05 | 滁州向日葵药业有限公司 | Traditional Chinese medicine composition for resisting helicobacter pylori infection and preparation method and application thereof |
| CN112316123B (en) * | 2020-12-03 | 2022-12-13 | 滁州向日葵药业有限公司 | Traditional Chinese medicine composition for resisting helicobacter pylori infection and preparation method and application thereof |
| CN113476556A (en) * | 2021-07-27 | 2021-10-08 | 天津济康药业有限公司 | Composition for inhibiting helicobacter pylori in oral cavity |
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