CN111643393A - Oral toothpaste for inhibiting helicobacter pylori and preparation device thereof - Google Patents

Oral toothpaste for inhibiting helicobacter pylori and preparation device thereof Download PDF

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Publication number
CN111643393A
CN111643393A CN202010670230.4A CN202010670230A CN111643393A CN 111643393 A CN111643393 A CN 111643393A CN 202010670230 A CN202010670230 A CN 202010670230A CN 111643393 A CN111643393 A CN 111643393A
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parts
groove
cavity
toothpaste
block
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CN111643393B (en
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黄晖
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Youtai Fujian Health Industry Co ltd
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Youtai Fujian Health Industry Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66Enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25Silicon; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/347Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02Local antiseptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/50Circulation mixers, e.g. wherein at least part of the mixture is discharged from and reintroduced into a receptacle
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80Mixing plants; Combinations of mixers
    • B01F33/83Mixing plants specially adapted for mixing in combination with disintegrating operations
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80Mixing plants; Combinations of mixers
    • B01F33/836Mixing plants; Combinations of mixers combining mixing with other treatments
    • B01F33/8361Mixing plants; Combinations of mixers combining mixing with other treatments with disintegrating
    • B01F33/83613Mixing plants; Combinations of mixers combining mixing with other treatments with disintegrating by grinding or milling
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/30Driving arrangements; Transmissions; Couplings; Brakes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/30Driving arrangements; Transmissions; Couplings; Brakes
    • B01F35/31Couplings
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/75Discharge mechanisms
    • B01F35/754Discharge mechanisms characterised by the means for discharging the components from the mixer
    • B01F35/7543Discharge mechanisms characterised by the means for discharging the components from the mixer using pneumatic pressure, overpressure or gas pressure in a closed receptacle or circuit system
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/19Mixing dentistry compositions

Abstract

The invention discloses an oral helicobacter pylori inhibition toothpaste and a preparation device thereof, wherein the oral helicobacter pylori inhibition toothpaste comprises the following raw materials in parts by weight: 9-12 parts of lysozyme, 35-42 parts of hydrated silica, 1-3 parts of lactoferrin, 1-3 parts of immunoglobulin (IgY), 1-3 parts of honeysuckle extract, 1-3 parts of bletilla extract, 1-2.8 parts of triclosan, 3-5 parts of glycerol, 4-6 parts of xanthan gum and the balance of deionized water, and the specific preparation method comprises the following steps: the weight ratio of the components is as follows: mixing and dispersing glycerol and xanthan gum uniformly, adding deionized water and hydrated silica, controlling the temperature to 90 ℃ for dispersing uniformly, cooling to 40 ℃, adding lysozyme, lactoferrin, honeysuckle extract, bletilla extract and triclosan, stirring and grinding for 50 minutes to obtain a toothpaste body, and filling in a sterile manner.

Description

Oral toothpaste for inhibiting helicobacter pylori and preparation device thereof
Technical Field
The invention relates to the technical field of toothpaste, in particular to oral helicobacter pylori inhibition toothpaste and a preparation device thereof.
Background
Helicobacter pylori diseases include gastritis, peptic ulcer, lymphoproliferative gastric lymphoma, etc. caused by infection with helicobacter pylori, which can be ingested by daily diet, and cleaning of the oral cavity is necessary because the oral cavity is in contact with the outside for a long time and the moist environment of the oral cavity causes a great increase in helicobacter pylori;
the toothpaste is a cleaning article commonly used in daily life, is a dentifrice, is generally in a gel shape, can be usually smeared on a toothbrush for cleaning teeth and keeping the teeth beautiful and bright, has a long history, and various types of toothpaste come out successively along with the continuous development of scientific technology, the continuous improvement and perfection of manufacturing processes and equipment;
the cleaning of helicobacter pylori in the oral cavity by tooth brushing is undoubtedly the simplest way for preventing and treating the helicobacter pylori, but the traditional toothpaste can only clean the oral cavity, and the cleaning effect of the helicobacter pylori is general, and the present example aims at inventing the toothpaste for inhibiting the helicobacter pylori in the oral cavity which is specially aimed at cleaning the helicobacter pylori and the processing device thereof.
Disclosure of Invention
In order to solve the problems, the embodiment designs an oral cavity toothpaste for inhibiting helicobacter pylori and a preparation method thereof, and the oral cavity toothpaste for inhibiting helicobacter pylori and the preparation method thereof comprise the following raw materials in parts by weight: 9-12 parts of lysozyme, 35-42 parts of hydrated silica, 1-3 parts of lactoferrin, 1-3 parts of immunoglobulin (IgY), 1-3 parts of honeysuckle extract, 1-3 parts of bletilla extract, 1-2.8 parts of triclosan, 3-5 parts of glycerol, 4-6 parts of xanthan gum and the balance of deionized water.
The preparation method comprises the following steps: the weight ratio of the components is as follows: mixing glycerol and xanthan gum, dispersing, adding deionized water and hydrated silica, controlling temperature at 90 deg.C, dispersing, cooling to 40 deg.C, adding lysozyme, lactoferrin, flos Lonicerae extract, rhizoma Bletillae extract, and triclosan, stirring, grinding for 50 min to obtain toothpaste, and aseptically packaging.
In this embodiment, the raw materials may further include, by weight: 11 parts of lysozyme, 36 parts of hydrated silica, 2 parts of lactoferrin, 3 parts of immunoglobulin (IgY), 2 parts of honeysuckle extract, 2 parts of bletilla extract, 3 parts of triclosan, 3 parts of glycerol, 4 parts of xanthan gum and the balance of deionized water.
In this embodiment, the raw materials may further include, by weight: 12 parts of lysozyme, 42 parts of hydrated silica, 1 part of lactoferrin, 2 parts of immunoglobulin (IgY), 1 part of honeysuckle extract, 1 part of bletilla extract, 1 part of triclosan, 4 parts of glycerol, 5 parts of xanthan gum and the balance of deionized water.
In this embodiment, the raw materials may further include, by weight: 1-4 parts of menthol and 4-10 parts of essence and saccharin mixture.
The invention also provides a preparation device for conveniently producing the toothpaste for inhibiting helicobacter pylori in oral cavity,
the preparation device comprises: the device comprises a bottom plate, a device main body is fixedly arranged on the upper side end face of the bottom plate, a stirring cavity is arranged in the device main body, an extrusion cavity is arranged in the inner wall of the lower side of the stirring cavity, a mixing cavity is arranged between the extrusion cavity and the stirring cavity in a communicated manner, an adding port communicated with the outside is arranged in the inner wall of the upper side of the stirring cavity, a driving motor is fixedly arranged in the inner wall of the upper side of the stirring cavity, the lower end of the driving motor is in power connection with a driving shaft, a rotating shaft is arranged on the lower side of the driving shaft, a spline groove with an upward opening and connected with a spline of the driving shaft is arranged in the rotating shaft, an upper top plate is fixedly arranged on the lower side end face of the rotating shaft, a lower top plate is arranged right below the upper top plate and positioned in the mixing cavity, an opening with an upward opening is arranged in the upper cylinder body, a threaded hole is arranged in the lower inner wall of the opening and is communicated with the lower inner wall of the lower top plate, a threaded rod capable of being in threaded connection with the threaded hole is fixedly arranged on the lower end surface of the lower top plate, a lower cylinder body is arranged right below the upper cylinder body, a spline sleeve groove with an upward opening is arranged in the lower cylinder body, a spline sleeve block in spline connection with the inner wall of the spline sleeve groove is slidably arranged in the spline sleeve groove, a taper groove with an upward opening is arranged in the spline sleeve block, a taper spline block capable of being clamped with the taper groove is fixedly arranged on the lower end surface of the upper cylinder body, an upper magnet and a lower magnet are fixedly arranged on the lower end surface of the spline sleeve block and the lower inner wall of the spline sleeve groove respectively, and an extrusion movable sheet fixed on the inner wall of the, a first groove with an outward opening is arranged in the extrusion movable sheet, a fixed extrusion block fixedly arranged on the inner wall of the extrusion cavity is arranged on the right side of the lower column body, a second groove with an outward opening is arranged in the fixed extrusion block, a transfer groove is arranged in the fixed extrusion block, the front side and the rear side of the transfer groove are respectively provided with an inlet communicated with the extrusion cavity, a first one-way valve ball is arranged in the transfer groove in a sliding way, an output pipe is arranged in the inner wall of the lower side of the transfer groove in a communicated manner, a switching component for switching paste circulation and output filling is arranged on the right side of the device main body, the switching component is communicated with the right end of the output pipe, a torsion spring cavity is arranged in the inner wall of the lower side of the extrusion cavity, and a torsion spring shaft is fixedly arranged on the lower side end face of the lower column body, and a torsion spring is fixedly connected between the torsion spring shaft and the inner wall of the torsion spring cavity.
Preferably, the switching assembly in the milling and filling equipment comprises an output pipe communicated with the right end of the output pipe as shown in the attached drawings and attached drawings, a circulating pipe with the upper end communicated with the stirring cavity is arranged on the upper side of the connecting pipe, a switching block is sleeved outside the circulating pipe and the connecting pipe and is connected with the circulating pipe in a sliding manner, a check valve ball chamber communicated with the lower end of the circulating pipe and the upper end of the connecting pipe is arranged in the switching block, a second check valve ball is slidably arranged in the output pipe, a filling pipe with the right end extending out of the right end face of the switching block is arranged on the right side of the check valve ball chamber, a gap communicated with the left end of the filling pipe is arranged in the connecting pipe, a jumping groove with a right opening is arranged in the right side of the device body, and a jumping block capable of sliding in the jumping groove is fixedly arranged on the left, the electromagnetic adjusting blocks are arranged on the rear end face of the jumping groove in a vertically symmetrical mode and are in magnetic connection with the jumping blocks.
Preferably, a temperature control circulating pipe is arranged in the arc-shaped inner wall of the peripheral side of the mixing cavity.
Preferably, when the T surface of the extrusion movable piece abuts against the T surface of the fixed extrusion block, the lower magnet and the upper magnet are de-energized, and when the K surface of the extrusion movable piece abuts against the K surface of the fixed extrusion block, the lower magnet and the upper magnet are energized and mutually repelled.
Preferably, the thickness of the lower top plate in the vertical direction is equal to the thickness of the first groove and the second groove in the vertical direction, and the lower top plate can slide in the first groove and the second groove.
Has the advantages that: the oral helicobacter pylori inhibiting toothpaste can clean helicobacter pylori in the oral cavity, drug properties remained in the oral cavity can limit the growth of the helicobacter pylori in the oral cavity, and the milling and filling equipment is simple in structure, can realize the functions of stirring, temperature control, filling and the like, and is simple and convenient to operate.
Drawings
For ease of illustration, the invention is described in detail by the following specific examples and figures.
FIG. 1 is a schematic view showing the overall configuration of an oral helicobacter pylori-inhibiting toothpaste manufacturing apparatus according to the present invention;
FIG. 2 is a schematic view showing the overall configuration of an oral helicobacter pylori-inhibiting toothpaste manufacturing apparatus according to the present invention;
FIG. 3 is an enlarged view of a portion of the structure of FIG. 1;
FIG. 4 is a schematic view of the structure in the direction "A-A" in FIG. 3;
fig. 5 is a schematic structural view of the notch in a top view direction.
Detailed Description
The present invention provides many applicable inventive concepts that can be embodied in a wide variety of specific contexts. The specific examples described in the following embodiments of the present invention are merely illustrative of specific implementations of the present invention and do not constitute limitations on the scope of the invention.
The invention relates to an oral helicobacter pylori inhibition toothpaste and a preparation device thereof, which are mainly applied to the production and processing process of the oral helicobacter pylori inhibition toothpaste, and the invention is further explained by combining the drawings of the invention as follows:
on one hand, the embodiment of the invention provides a preparation method of an oral helicobacter pylori inhibition toothpaste, which comprises the following raw materials in parts by weight: 9-12 parts of lysozyme, 35-42 parts of hydrated silica, 1-3 parts of lactoferrin, 1-3 parts of immunoglobulin (IgY), 1-3 parts of honeysuckle extract, 1-3 parts of bletilla extract, 1-2.8 parts of triclosan, 3-5 parts of glycerol, 4-6 parts of xanthan gum and the balance of deionized water;
the preparation method comprises the following steps: the weight ratio of the components is as follows: mixing glycerol and xanthan gum, dispersing, adding deionized water and hydrated silica, controlling temperature at 90 deg.C, dispersing, cooling to 40 deg.C, adding lysozyme, lactoferrin, immunoglobulin (IgY), flos Lonicerae extract, rhizoma Bletillae extract, and triclosan, stirring, grinding for 50 min to obtain toothpaste, and aseptically packaging;
the grinding and filling are realized by a grinding and filling device, the grinding and filling device comprises a bottom plate 101, a device main body 115 is fixedly arranged on the upper end face of the bottom plate 101, a stirring cavity 114 is arranged in the device main body 115, an extrusion cavity 107 is arranged in the lower inner wall of the stirring cavity 114, a mixing cavity 109 is arranged between the extrusion cavity 107 and the stirring cavity 114 and communicated with the outside, an adding port 121 communicated with the outside and used for adding raw materials is arranged in the upper inner wall of the stirring cavity 114, a driving motor 116 is fixedly arranged in the upper inner wall of the stirring cavity 114, the lower end of the driving motor 116 is in power connection with a driving shaft 117, a rotating shaft 119 is arranged on the lower side of the driving shaft 117, a spline groove 118 with an upward opening and in spline connection with the driving shaft 117 is arranged in the rotating shaft 119, and an upper top plate 112 is fixedly, a lower top plate 133 is arranged right below the upper top plate 112 and in the mixing cavity 109, a spiral volute blade 111 is fixedly arranged between the lower top plate 133 and the upper top plate 112, stirring or conveying of toothpaste is realized through the forward and reverse rotation of the spiral volute blade 111, an upper cylinder 138 is arranged on the lower side of the lower top plate 133, an opening 136 with an upward opening is arranged in the upper cylinder 138, a threaded hole 139 with a threaded hole engraved on the inner wall is arranged in the inner wall of the lower side of the opening 136 in a communicating manner, a threaded rod 137 which can be in threaded connection with the threaded hole 139 is fixedly arranged on the lower side end surface of the lower top plate 133, a lower cylinder 152 which is in sliding connection with the inner wall of the extrusion cavity 107 is arranged right below the upper cylinder 138, a spline sleeve groove 142 with an upward opening is arranged in the lower cylinder 152, and a spline sleeve block 147 which is in spline connection with the inner wall of the spline sleeve groove 142 is slidably arranged, a conical groove 143 with an upward opening is formed in the spline sleeve 147, a conical spline block 141 capable of being clamped with the conical groove 143 is fixedly arranged on the lower side end face of the upper cylinder 138, an upper magnet 144 and a lower magnet 146 are fixedly arranged on the lower side end face of the spline sleeve 147 and the lower inner wall of the spline sleeve 142 respectively, the lower magnet 146 and the upper magnet 144 are used for controlling the clamping and disengaging state of the conical groove 143 and the conical spline block 141, an extrusion movable plate 108 fixed on the inner wall of the lower top plate 133 is fixedly arranged on the left side face of the lower cylinder 152, a first groove 132 with an outward opening is formed in the extrusion movable plate 108, a fixed extrusion block 148 fixedly arranged on the inner wall of the extrusion cavity 107 is arranged on the right side of the lower cylinder 152, a second groove 134 with an outward opening is formed in the fixed extrusion block 148, and a transfer groove 149 is formed in the fixed extrusion block 148, the front side and the rear side of the transfer groove 149 are respectively provided with an inlet 154 communicated with the extrusion cavity 107, a first one-way valve ball 151 is slidably arranged in the transfer groove 149, an output tube 105 is communicated in the inner wall of the lower side of the transfer groove 149, toothpaste is extruded into the output tube 105 by the extrusion of the extrusion movable sheet 108 and the fixed extrusion block 148, the right side of the device main body 115 is provided with a switching component for switching the circulation and the output filling of the toothpaste, the switching component is communicated with the right end of the output tube 105, a torsion spring cavity 102 is arranged in the inner wall of the lower side of the extrusion cavity 107, a torsion spring shaft 103 which is rotatably connected with the device main body 115 and extends into the torsion spring cavity 102 is fixedly arranged on the end surface of the lower side of the lower column body 152, a torsion spring 104 is fixedly connected between the torsion spring shaft 103 and the inner wall of the torsion spring cavity 102, the raw materials added into the stirring cavity 114 and the mixing cavity 109 through the adding port 121 can be stirred and the processed paste body can be conveyed through the forward and reverse rotation of the spiral worm fan blade 111, the paste body of the toothpaste can be extruded through the extrusion of the extrusion movable blade 108 and the fixed extrusion block 148, and the air contained in the paste body can be extruded through the extrusion of the extrusion movable blade 108 and the fixed extrusion block 148.
In this embodiment, the switching component in the milling and filling equipment includes an output tube 105 connected to the right end of the output tube 105 as shown in the state of fig. 1 and fig. 2, a circulating tube 122 with an upper end connected to the stirring chamber 114 is disposed on the upper side of the connecting tube 106, a switching block 123 is sleeved on the outer sides of the circulating tube 122 and the connecting tube 106, the circulating tube 122 is slidably connected to the connecting tube 106, a check valve ball chamber 125 communicated with the lower end of the circulating tube 122 and the upper end of the connecting tube 106 is disposed in the switching block 123, a second check valve ball 126 is slidably disposed in the output tube 105, a filling tube 124 with a right end extending out of the right end face of the switching block 123 is disposed on the right side of the check valve ball chamber 125, a notch 127 capable of communicating with the left end of the filling tube 124 is disposed in the connecting tube 106, a jump groove 129 with a right, a jump block 128 capable of sliding in the jump groove 129 is fixedly arranged on the left end face of the switching block 123, electromagnetic adjusting blocks 131 which are symmetrical up and down are fixedly arranged on the rear end face of the jump groove 129, the electromagnetic adjusting blocks 131 are magnetically connected with the jump block 128, the jump block 128 can be driven to slide up and down in the jump groove 129 by the on-off of the electromagnetic adjusting blocks 131, and then the toothpaste circulation mode and the output filling mode are adjusted by the up-down sliding of the switching block 123.
In this embodiment, as shown in the states of fig. 1 and fig. 2, a temperature control circulation pipe 113 is disposed inside the arc-shaped inner wall of the peripheral side of the mixing chamber 109, and the temperature inside the mixing chamber 109 can be controlled by warm water, so as to control the temperature of the toothpaste processing environment.
In this embodiment, as shown in fig. 1 and fig. 2, when the T-surface of the movable extrusion piece 108 abuts against the T-surface of the fixed extrusion block 148, the lower magnet 146 and the upper magnet 144 are de-energized, at this time, the spline sleeve 147 descends under the action of gravity, the tapered groove 143 is disengaged from the tapered spline block 141, and then the movable extrusion piece 108 is driven by the torsion spring 104 to return to the initial state, when the K-surface of the movable extrusion piece 108 abuts against the K-surface of the fixed extrusion block 148, the lower magnet 146 and the upper magnet 144 are energized to repel each other, and further the spline sleeve 147 is pushed to ascend, so that the tapered spline block 141 is clamped into the tapered groove 143, and at this time, the rotated tapered spline block 141 can drive the spline sleeve 147 and the lower cylinder 152 to rotate.
Advantageously, the thickness of the lower top plate 133 in the up-down direction is equal to the thickness of the first groove 132 and the second groove 134 in the up-down direction, and the lower top plate 133 can slide in the first groove 132 and the second groove 134.
Example (A)
Example 1
The embodiment provides an oral helicobacter pylori inhibition toothpaste and a preparation method thereof, wherein the oral helicobacter pylori inhibition toothpaste comprises the following raw materials in parts by weight: 11 parts of lysozyme, 36 parts of hydrated silica, 2 parts of lactoferrin, 3 parts of immunoglobulin (IgY), 2 parts of honeysuckle extract, 2 parts of bletilla extract, 3 parts of triclosan, 3 parts of glycerol, 4 parts of xanthan gum and the balance of deionized water;
the preparation method comprises the following steps: the weight ratio of the components is as follows: mixing and dispersing glycerol and xanthan gum uniformly by the grinding and filling equipment, adding deionized water and hydrated silica, controlling the temperature to 90 ℃ for uniform dispersion, cooling to 40 ℃, adding lysozyme, lactoferrin, a honeysuckle extract, a bletilla striata extract and triclosan, stirring and grinding for 50 minutes to obtain a toothpaste body, and filling in an aseptic manner.
Example 2
The embodiment provides an oral helicobacter pylori inhibition toothpaste and a preparation method thereof, wherein the oral helicobacter pylori inhibition toothpaste comprises the following raw materials in parts by weight: 12 parts of lysozyme, 42 parts of hydrated silica, 1 part of lactoferrin, 2 parts of immunoglobulin (IgY), 1 part of honeysuckle extract, 1 part of bletilla extract, 1 part of triclosan, 4 parts of glycerol, 5 parts of xanthan gum and the balance of deionized water;
the preparation method is the same as example 1.
Example 3
The embodiment provides an oral helicobacter pylori inhibition toothpaste and a preparation method thereof, wherein the oral helicobacter pylori inhibition toothpaste comprises the following raw materials in parts by weight: 1-4 parts of menthol and 4-10 parts of essence and saccharin mixture are added on the basis of the mixture ratio of the raw materials in the embodiment 1;
the preparation method is the same as example 1.
Example 4
The embodiment provides an oral helicobacter pylori inhibition toothpaste and a preparation method thereof, wherein the oral helicobacter pylori inhibition toothpaste comprises the following raw materials in parts by weight: on the basis of the mixture ratio of the raw materials in the embodiment 2, 1-4 parts of menthol and 4-10 parts of essence and saccharin mixture are added;
the preparation method is the same as example 1.
The toothpaste prepared by the above examples is uniform and has no foreign matters, and the flavor and color are normal. The room temperature consistency and the heat-resistant consistency are both normal, the stability is normal, the phenomena of water separation and shelling are avoided, the abnormal color change condition is avoided, the pH value is in a standard range, and no excessively hard particles exist. Wherein, the drug properties of various medicines are changed by adjusting the weight ratio among the raw materials in the examples 1 and 2, and the mouthfeel brought by using the toothpaste body is changed by adding the mixture of menthol, essence and saccharin in the examples 3 and 4.
When the milling and filling equipment is in an initial state, the lower top plate 133 is located in the mixing cavity 109, the threaded rod 137 is located in the opening 136, the threaded rod 137 is out of threaded connection with the threaded hole 139, the rotating shaft 119 is lifted in the stirring cavity 114 to the maximum extent, the switching block 123 is lifted to the maximum extent, and at this time, the K surface of the extrusion movable piece 108 is abutted to the K surface of the fixed extrusion block 148.
The processing process of the milling and filling equipment comprises the following steps:
(1): glycerol and xanthan gum are added into the stirring cavity 114 through the adding port 121, at this time, the driving motor 116 is started to drive the driving shaft 117 to rotate, and further the rotating shaft 119 drives the upper top plate 112 and the spiral volute 111 to rotate forward, at this time, because the lower top plate 133 is located in the mixing cavity 109, the mixing cavity 109 is further isolated from the extrusion cavity 107, at this time, the spiral volute 111 rotating forward mixes and stirs the glycerol and the xanthan gum added into the mixing cavity 109, after the glycerol and the xanthan gum are uniformly stirred, a user adds plasma water and hydrated silica into the stirring cavity 114 through the adding port 121, and simultaneously inputs 90 ℃ warm water into the temperature control circulating pipe 113, so as to control the temperature of the processing environment in the mixing cavity 109, and secondly, adding lysozyme, lactoferrin, immunoglobulin (IgY), a honeysuckle extract, a bletilla striata extract and triclosan, stirring and grinding, controlling the temperature of warm water input into the temperature control circulating pipe 113 to be 40 ℃, and continuously stirring for 50 minutes by the spiral volute sheet 111;
(2) after the toothpaste body is obtained after stirring, the driving motor 116 drives the rotating shaft 119 to rotate in the reverse direction, at this time, under the action of the gravity of the rotating shaft 119 and the spiral fan blade 111, the lower end of the threaded rod 137 rotating in the reverse direction gradually rotates into the threaded hole 139, and simultaneously drives the lower top plate 133 to gradually descend, when the threaded rod 137 descends in the threaded hole 139 to the maximum extent and the lower top plate 133 descends into the first groove 132 and the second groove 134, the driving motor 116 continues to drive the spiral fan blade 111 to rotate in the reverse direction, at this time, the toothpaste body in the mixing cavity 109 and the stirring cavity 114 is conveyed into the extrusion cavity 107 by the spiral fan blade 111 rotating in the reverse direction, and at the same time, the lower cylinder 152 is driven to rotate by the spiral fan blade 111 through the threaded rod 137 and the upper cylinder 138, so as to drive the extrusion movable blade 108 to rotate, the toothpaste body is squeezed into the inlet 154 by squeezing between the squeezing movable sheet 108 and the fixed squeezing block 148 in the rotating process of the squeezing movable sheet 108, when two T surfaces are abutted, the conical spline block 141 is separated from the conical groove 143, the lower column body 152 is restored to the initial state under the driving of the torsion spring 104 and the two K surfaces are abutted, the toothpaste between the two K surfaces is squeezed into the transfer groove 149 in the reversing process of the squeezing movable sheet 108, and air in the toothpaste body can be squeezed out by squeezing between the two K surfaces or between the two T surfaces;
(3) the electromagnetic adjusting block 131 on the upper side or the lower side is electrified to drive the switching block 123 to move up and down, so that the inner wall circulation and output filling work of the toothpaste body is adjusted, after the switching block 123 rises to the maximum, the toothpaste body enters the stirring cavity 114 through the output pipe 105, the connecting pipe 106, the one-way valve ball chamber 125 and the circulating pipe 122, and after the switching block 123 descends to the maximum, the toothpaste body is output through the output pipe 105, the connecting pipe 106, the notch 127 and the filling pipe 124 to be filled.
In the above manner, a person skilled in the art can make various changes depending on the operation mode within the scope of the present invention.

Claims (10)

1. An oral helicobacter pylori-inhibiting toothpaste, which is characterized in that: the feed comprises the following raw materials in parts by weight: 9-12 parts of lysozyme, 35-42 parts of hydrated silica, 1-3 parts of lactoferrin, 1-3 parts of immunoglobulin (IgY), 1-3 parts of honeysuckle extract, 1-3 parts of bletilla extract, 1-2.8 parts of triclosan, 3-5 parts of glycerol, 4-6 parts of xanthan gum and the balance of deionized water.
2. The oral helicobacter pylori inhibiting toothpaste according to claim 1, wherein: the toothpaste comprises the following raw materials in parts by weight: 11 parts of lysozyme, 36 parts of hydrated silica, 2 parts of lactoferrin, 3 parts of immunoglobulin (IgY), 2 parts of honeysuckle extract, 2 parts of bletilla extract, 3 parts of triclosan, 3 parts of glycerol, 4 parts of xanthan gum and the balance of deionized water.
3. The oral helicobacter pylori inhibiting toothpaste according to claim 1, wherein: the toothpaste comprises the following raw materials in parts by weight: 12 parts of lysozyme, 42 parts of hydrated silica, 1 part of lactoferrin, 2 parts of immunoglobulin (IgY), 1 part of honeysuckle extract, 1 part of bletilla extract, 1 part of triclosan, 4 parts of glycerol, 5 parts of xanthan gum and the balance of deionized water.
4. The oral helicobacter pylori inhibiting toothpaste according to claim 1, wherein: the toothpaste also comprises 1-4 parts of menthol and 4-10 parts of essence and saccharin mixture.
5. The oral helicobacter pylori inhibiting toothpaste according to claim 1, wherein: the preparation method of the toothpaste comprises the following steps: the weight ratio of the components is as follows: mixing glycerol and xanthan gum, dispersing, adding deionized water and hydrated silica, controlling temperature at 90 deg.C, dispersing, cooling to 40 deg.C, adding lysozyme, lactoferrin, immunoglobulin (IgY), flos Lonicerae extract, rhizoma Bletillae extract, and triclosan, stirring, grinding for 50 min to obtain toothpaste, and aseptically packaging.
6. A manufacturing apparatus of the oral helicobacter pylori-inhibiting toothpaste as claimed in claim 1, wherein: the device comprises a bottom plate, a device main body is fixedly arranged on the upper side end surface of the bottom plate, a stirring cavity is arranged in the device main body, an extrusion cavity is arranged in the lower side inner wall of the stirring cavity, a mixing cavity is arranged between the extrusion cavity and the stirring cavity in a communicated manner, an adding port communicated with the outside is arranged in the upper side inner wall of the stirring cavity, a driving motor is fixedly arranged in the upper side inner wall of the stirring cavity, the lower end of the driving motor is in power connection with a driving shaft, a rotating shaft is arranged on the lower side of the driving shaft, a spline groove with an upward opening and connected with a spline of the driving shaft is arranged in the rotating shaft, an upper top plate is fixedly arranged on the lower side end surface of the rotating shaft, a lower top plate is arranged right below the upper top plate and positioned in the mixing cavity, a spiral volute sheet is, an opening with an upward opening is arranged in the upper cylinder body, a threaded hole is arranged in the lower inner wall of the opening and is communicated with the lower inner wall of the lower top plate, a threaded rod capable of being in threaded connection with the threaded hole is fixedly arranged on the lower end surface of the lower top plate, a lower cylinder body is arranged right below the upper cylinder body, a spline sleeve groove with an upward opening is arranged in the lower cylinder body, a spline sleeve block in spline connection with the inner wall of the spline sleeve groove is slidably arranged in the spline sleeve groove, a taper groove with an upward opening is arranged in the spline sleeve block, a taper spline block capable of being clamped with the taper groove is fixedly arranged on the lower end surface of the upper cylinder body, an upper magnet and a lower magnet are fixedly arranged on the lower end surface of the spline sleeve block and the lower inner wall of the spline sleeve groove respectively, and an extrusion movable sheet fixed on the inner wall of the, a first groove with an outward opening is arranged in the extrusion movable sheet, a fixed extrusion block fixedly arranged on the inner wall of the extrusion cavity is arranged on the right side of the lower column body, a second groove with an outward opening is arranged in the fixed extrusion block, a transfer groove is arranged in the fixed extrusion block, the front side and the rear side of the transfer groove are respectively provided with an inlet communicated with the extrusion cavity, a first one-way valve ball is arranged in the transfer groove in a sliding way, an output pipe is arranged in the inner wall of the lower side of the transfer groove in a communicated manner, a switching component for switching paste circulation and output filling is arranged on the right side of the device main body, the switching component is communicated with the right end of the output pipe, a torsion spring cavity is arranged in the inner wall of the lower side of the extrusion cavity, and a torsion spring shaft is fixedly arranged on the lower side end face of the lower column body, and a torsion spring is fixedly connected between the torsion spring shaft and the inner wall of the torsion spring cavity.
7. The manufacturing apparatus as set forth in claim 6, wherein: the switching assembly comprises an output pipe at the right end of the output pipe, a circulating pipe with the upper end communicated with the stirring cavity is arranged on the upper side of the connecting pipe, a switching block is sleeved on the outer side of the circulating pipe and the connecting pipe, the circulating pipe is connected with the connecting pipe in a sliding manner, a one-way valve ball chamber communicated with the lower end of the circulating pipe and the upper end of the connecting pipe is arranged in the switching block, a second one-way valve ball is slidably arranged in the output pipe, a filling pipe with the right end extending out of the right end face of the switching block is arranged on the right side of the one-way valve ball chamber, a gap communicated with the left end of the filling pipe is arranged in the connecting pipe, a jumping groove with a right opening is arranged in the right side face of the device main body, a jumping block capable of sliding in the jumping groove is fixedly arranged on the left end face of, the electromagnetic adjusting block is magnetically connected with the jumping block.
8. The manufacturing apparatus as set forth in claim 7, wherein: and a temperature control circulating pipe is arranged in the arc-shaped inner wall of the peripheral side of the mixing cavity.
9. The manufacturing apparatus of claim 8, wherein: when the T surface of the extrusion movable sheet is abutted against the T surface of the fixed extrusion block, the lower magnet is electrically disconnected with the upper magnet, and when the K surface of the extrusion movable sheet is abutted against the K surface of the fixed extrusion block, the lower magnet is electrically disconnected with the upper magnet.
10. The manufacturing apparatus as set forth in claim 6, wherein: the thickness of the lower top plate in the vertical direction is equal to the thickness of the first groove and the second groove in the vertical direction, and the lower top plate can slide in the first groove and the second groove.
CN202010670230.4A 2020-07-13 2020-07-13 Oral helicobacter pylori inhibition toothpaste and preparation device thereof Active CN111643393B (en)

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CN112438940A (en) * 2020-12-17 2021-03-05 宁波市朱氏贸易有限公司 Toothpaste capable of effectively inhibiting oral helicobacter pylori
CN112494401A (en) * 2020-12-17 2021-03-16 江门市金本士贸易有限公司 Anti-bacterial traditional Chinese medicine toothpaste capable of removing yellow, whitening and resisting helicobacter pylori
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