CN110507583A - A kind of efficient prevention and control helicobacter pylori fresh breath toothpaste and preparation method thereof - Google Patents
A kind of efficient prevention and control helicobacter pylori fresh breath toothpaste and preparation method thereof Download PDFInfo
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- CN110507583A CN110507583A CN201910924060.5A CN201910924060A CN110507583A CN 110507583 A CN110507583 A CN 110507583A CN 201910924060 A CN201910924060 A CN 201910924060A CN 110507583 A CN110507583 A CN 110507583A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses a kind of efficient prevention and control helicobacter pylori fresh breath toothpaste and preparation method thereof, more particularly to biology and chemical technology field, the main component of the toothpaste of preparation is unique a kind of specific immunity livetin powder of tetravalence type (tetravalence refers to 1. HapA adhesin 2. Vac cavitating toxin 3. CAG cytotoxin-associated gene 4. URE urease) and natural plant extracts leaf of Moringa powder both at home and abroad at present.The present invention has two large effects: first is that prevention and control oral helicobacter pylori；Second is that removing removing abnormal flavor in oral cavity, in addition this product has certain protective effect to liver stomach function regulating, while playing the role of prevention and control to the harmful bacteria in stomach.Without any side effects, effective protection oral health of the invention.
Description
Technical field
The invention belongs to biology and chemical technology fields, and in particular to a kind of efficient prevention and control helicobacter pylori fresh breath toothpaste
And preparation method thereof.
Background technique
Oral helicobacter pylori is a kind of oral cavity and stomach bacterium, can trigger disease of stomach, can often cause chronic
Enterogastritis and gastric ulcer, if taking measures to be treated not in time, it is also possible to malignant change occur, induce cancer.Pylorus
This germ of helicobacter mainly enters from oral cavity, stomach lactation madness will be stimulated to secrete once catching helicobacter pylori, thus
Cause the symptoms such as gastric acid, stomachache, heartburn；Helicobacter pylori also results in patient and the phenomenon that pain occurs, between patients whose symptoms were less severe are
It has a rest pain, and symptom can be with violent colic pain compared with severe one, and it can recurrent exerbation.Since helicobacter pylori can make in inside of human body
At many urine poison bacteriums, takes root, can be evaporated from mouth, so as to cause generation because helicobacter pylori can be resident in oral cavity
Intractable halitosis, and as the latent of helicobacter pylori leads to aggravation, to can cause vomiting, the chronic gastroenteropathies such as diarrhea
Illness.Therefore noted that oral hygiene, prevent that illness finds its way in by the mouth, increasingly becomes prevention helicobacter pylori infections, prevent stomach trouble and stomach
The important measures of cancer.
Most of oral cares class product such as presently commercially available common health-care toothpaste using synthesis chemicals make antibacterial at
Point, synthetic antibacterial agents are used for a long time, and to human body, there are potentially hazardous and safety issues.Although having some medium-height grass in the market
Medicine health-care toothpaste, but antibacterial effect is also not ideal enough, does not have especially and kills helicobacter pylori activity.
Therefore, it is badly in need of a kind of efficient prevention and control helicobacter pylori fresh breath toothpaste for solving existing issue.
Summary of the invention
The object of the present invention is to provide a kind of efficient prevention and control helicobacter pylori fresh breath toothpaste and preparation method thereof, preparations
Toothpaste can prevention and control oral helicobacter pylori, remove removing abnormal flavor in oral cavity.
The technical solution of the present invention is as follows:
A kind of efficient prevention and control helicobacter pylori fresh breath toothpaste includes H. pylori bacterial type IgY and moringa oleifera leaf extractive.It is deep and remote
Door screw rod bacterial type IgY is that (tetravalence refers to 1. HapA for the product of Yolk immune globulin of the prevention and control helicobacter pylori of tetravalence type
Adhesin 2. Vac cavitating toxin 3. CAG cytotoxin-associated gene 4. URE urease), known HP type both at home and abroad at present
Yolk immune ball product is mostly using single Ure as antigen.It goes to influence by the high-immunity egg Huang of anti-helicobacter pylori specific IgY
Urel(Urel is a kind of protein for being responsible for specially adjusting urease in cytoplasm, plays " proton channel ", can control and enter bacterium
The gastric acid amount of body), so that thallus is lost protection, can not survive under strong acid environment, to effectively inhibit or eliminate H. pylori
Bacterium；With more excellent antigenicity and immunogenicity, from it is multi-faceted, mostly by way of inhibiting and eliminate helicobacter pylori.And leaf of Moringa
Extract has hypoglycemic, antitumor, anti-inflammatory, anti-oxidant and adjusting immunity isoreactivity and H. pylori bacterial type IgY cooperation
Inhibit and elimination helicobacter pylori effect is more preferable.
Preferably, including component A, B component and component C, weight ratio ingredient are as follows:
A: 20-40 parts of hydrated silica, 1-5 parts of cellulose gum, 3-5 parts of laruyl alcohol sodium sulfovinate；
B: 0.1-0.5 parts of H. pylori bacterial type IgY, 0.1-0.5 parts of moringa oleifera leaf extractive, 30-60 parts of sorb (sugar) alcohol,
0.1-0.25 parts of sodium benzoate, 0.14-0.15 parts of saccharin sodium, 10-20 parts of pure water；
C: 1-3 parts of menthol, 0.1-0.5 parts of edible essence.
Preferably, including component A, B component and component C, weight ratio ingredient are as follows:
A: 30 parts of hydrated silica, 3 parts of cellulose gum, 4 parts of laruyl alcohol sodium sulfovinate；
B: 0.3 part of H. pylori bacterial type IgY, 0.2 part of moringa oleifera leaf extractive, 45 parts of sorb (sugar) alcohol, sodium benzoate 0.2
Part, 0.14 part of saccharin sodium, 14.86 parts of pure water；
C: 2 parts of menthol, 0.3 part of edible essence.
A kind of preparation method of efficient prevention and control helicobacter pylori fresh breath toothpaste, includes the following steps:
S1, each raw material of B component is mixed evenly, obtains mixed liquor；
Component A is added in S2, the mixed liquor obtained into step S1, is mixed evenly, and carries out emulsification treatment, obtains paste
Object；
Component C is added in S3, the paste obtained into step S2, is mixed evenly, carries out homogenization, vacuumizes to obtain institute
State anti-oral helicobacter pylori medicated toothpaste.
A kind of H. pylori bacterial type in B component IgY's the preparation method is as follows:
1) using H. pylori strain as antigen, mixing and blowing and beating with incomplete Freund's adjuvant 1:1 makes it emulsify uniform obtain
To H. pylori strain emulsion；
2) in the two sides chicken wings of laying hen and thigh root injecting step 1) obtain H. pylori strain emulsion, each portion
0.25 mL of position, every 7 days immune primary, is immunized 4 times altogether；
3) egg is collected and marked daily after being immunized, and extracts egg yolk liquid with syringe, and extract the H. pylori in egg yolk liquid
Bacterial type IgY is freeze-dried into product
The utility model has the advantages that
First is that prevention and control oral helicobacter pylori；Second is that removing removing abnormal flavor in oral cavity, in addition this product has certain guarantor to liver stomach function regulating
Shield effect, while playing the role of prevention and control to the harmful bacteria in stomach.The present invention is without any side effects, and effective protection oral cavity is strong
Health.
Specific embodiment
Embodiment 1
The preparation of H. pylori bacterial type IgY:
(1) laying hen is immune
The Bai Laihang laying hen of 38 week old is raised in the workbench of ultra-clean, and (pH 6.2 needs to steam by high pressure feed with water
Vapour sterilizing.Before laying hen is immune, with cell concentration for 109-1011The H. pylori strain of CFU/mL is as antigen, with Freund
Freund's incomplete adjuvant 1:1, which is mixed and blown and beaten, makes its emulsification uniformly obtain H. pylori strain emulsion.The two of (A group) laying hen
The H. pylori strain emulsion that side chicken wings and thigh root injection have pre-processed, each 0.25 mL of position, every 7 days
It is immune primary, it is immunized 4 times altogether.Isometric mixed liquor of control group (B group) laying hen injecting normal saline and incomplete Freund's adjuvant.
Medicine-feeding part and the same experimental group of dosage.Egg, 4 DEG C of storages are collected and marked after immune daily.
(2) extract and purify IgY
Egg surface is wiped with medicinal alcohol cotton rub, knocks against egg shell hard, extract egg yolk liquid with 10 mL syringes and records volume,
It is diluted and is sufficiently mixed (0.1 mol HCl is adjusted to pH 5.0) with the ultrapure water (1:9) of pre-cooling, then stored at 4 DEG C
Night.Solution is centrifuged 45 min at 5000 g, 4 DEG C, ammonium sulfate is added into supernatant makes final saturation degree 45, then
2.5 h are placed at 4 DEG C.After being centrifuged 12 min at 5000 g, 4 DEG C, liquid is discarded supernatant, 1:1 adds ultrapure water solubilising protein
Precipitating, sodium sulphate, which is then added, makes the final mass score of solution reach 13, stands 2.5h after dissolution is stirred at room temperature；4 DEG C of conditions
Lower 5000 g are centrifuged 12 min again, and sediment is dissolved in PBS.Solution is dialysed, and (every 1.5 h replacement is primary ultrapure by 6h
Water), then soaked overnight and stored at one 20 DEG C in PBS.The IgY purified from A group ovum after immune is specific IgY
(S-IgY), B group is negative control IgY (C-IgY).With Amicon Ultra-15 centrifugal filter device (Millipore,
Burlinton, the U.S.) by the IgY of purifying with 4000 g ultrafiltration be centrifuged 10 min to achieve the purpose that desalination and concentrated antibody, freezing
It is dried to product.
It is compared with B group, is reached using the special yolk antibody potency that ELISA (enzyme-linked immunosorbent assay) measures A group
1:2500000。
H. pylori bacterial type IgY is the product (four of the Yolk immune globulin of the prevention and control helicobacter pylori of tetravalence type
Valence refers to 1. HapA adhesin 2. Vac cavitating toxin 3. CAG cytotoxin-associated gene 4. URE urease), at present both at home and abroad
Known HP type Yolk immune ball product is mostly using single Ure as antigen.Pass through the high-immunity egg of anti-helicobacter pylori specific IgY
Huang goes to influence Urel(Urel to be a kind of protein for being responsible for specially adjusting urease in cytoplasm, plays " proton channel ", controllably
System enters the gastric acid amount of thallus), so that thallus is lost protection, can not survive under strong acid environment, to effectively inhibit or eliminate deep and remote
Door pylori；With more excellent antigenicity and immunogenicity, from it is multi-faceted, mostly by way of inhibiting and eliminate helicobacter pylori.
Embodiment 2
Control group toothpaste and 3 groups of experimental group toothpaste are made according to the following ratio, and 3 groups of experimental group toothpaste are respectively designated as experiment 1, reality
Test 2 and experiment 3.
1 raw material of toothpaste of table proportion
Toothpaste the production method is as follows:
S1, each raw material of B component is mixed evenly, obtains mixed liquor；
Component A is added in S2, the mixed liquor obtained into step S1, is mixed evenly, and carries out emulsification treatment, obtains paste
Object；
Component C is added in S3, the paste obtained into step S2, is mixed evenly, carries out homogenization, vacuumizes to obtain tooth
Cream.
Embodiment 3
Performance test
Investigate this product prevention and control helicobacter pylori and go oral peculiar smell experimental method: 200 Hp positive patients of selection are divided into treatment
Group 1(50), treatment group 2(50), treatment group 3 (50) and control group (50), treatment group 1, treatment group 2 and treat
The toothpaste that experiment 1, experiment 2 and the experiment 3 that group 3 is respectively adopted in embodiment 2 obtain is brushed teeth, 2 times a day (once in the morning and once at night),
Toothpaste morning and evening 2 times daily that control group is obtained using the control group in embodiment 2, service life is 2 months, after being discontinued 1 month
Statistics becomes negative rate and oral peculiar smell removes situation, as a result as follows:
2 prevention and control helicobacter pylori experimental result of table
| Treatment group 1 | Treatment group 2 | Treatment group 3 | Control group | |
| Turn out cloudy (people) | 21 | 18 | 22 | 0 |
| Oral peculiar smell removes (people) | 32 | 35 | 30 | 0 |
| Oral peculiar smell be improved significantly (people) | 50 | 50 | 50 | 0 |
The above experimental data proves this product significant effect, and H. pylori bacterial type IgY and Moringa extract play wherein
The proportion of obvious action, H. pylori bacterial type IgY and Moringa extract plays an important role.
It is worth noting that oral peculiar smell be improved significantly comprising oral peculiar smell remove.
Claims (5)
1. a kind of efficient prevention and control helicobacter pylori fresh breath toothpaste, which is characterized in that comprising H. pylori bacterial type IgY and peppery
The wooden leaf extract.
2. efficient prevention and control helicobacter pylori fresh breath toothpaste according to claim 1, which is characterized in that including component A,
B component and component C, weight ratio ingredient are as follows:
A: 20-40 parts of hydrated silica, 1-5 parts of cellulose gum, 3-5 parts of laruyl alcohol sodium sulfovinate；
B: 0.1-0.5 parts of H. pylori bacterial type IgY, 0.1-0.5 parts of moringa oleifera leaf extractive, 30-60 parts of sorb (sugar) alcohol,
0.1-0.25 parts of sodium benzoate, 0.14-0.15 parts of saccharin sodium, 10-20 parts of pure water；
C: 1-3 parts of menthol, 0.1-0.5 parts of edible essence.
3. efficient prevention and control helicobacter pylori fresh breath toothpaste according to claim 2, which is characterized in that including component A,
B component and component C, weight ratio ingredient are as follows:
A: 30 parts of hydrated silica, 3 parts of cellulose gum, 4 parts of laruyl alcohol sodium sulfovinate；
B: 0.3 part of H. pylori bacterial type IgY, 0.2 part of moringa oleifera leaf extractive, 45 parts of sorb (sugar) alcohol, sodium benzoate 0.2
Part, 0.14 part of saccharin sodium, 14.86 parts of pure water；
C: 2 parts of menthol, 0.3 part of edible essence.
4. a kind of preparation method of efficient prevention and control helicobacter pylori fresh breath toothpaste described in claim 2 or 3, feature exist
In including the following steps:
S1, each raw material of B component is mixed evenly, obtains mixed liquor；
Component A is added in S2, the mixed liquor obtained into step S1, is mixed evenly, and carries out emulsification treatment, obtains paste
Object；
Component C is added in S3, the paste obtained into step S2, is mixed evenly, carries out homogenization, vacuumizes to obtain institute
State anti-oral helicobacter pylori medicated toothpaste.
5. the preparation method of efficient prevention and control helicobacter pylori fresh breath toothpaste according to claim 4, which is characterized in that
H. pylori bacterial type in B component IgY's the preparation method is as follows:
1) using H. pylori strain as antigen, mixing and blowing and beating with incomplete Freund's adjuvant 1:1 makes it emulsify uniform obtain
To H. pylori strain emulsion；
2) in the two sides chicken wings of laying hen and thigh root injecting step 1) obtain H. pylori strain emulsion, each portion
0.25 mL of position, every 7 days immune primary, is immunized 4 times altogether；
3) egg is collected and marked daily after being immunized, and extracts egg yolk liquid with syringe, and extract the H. pylori in egg yolk liquid
Bacterial type IgY is freeze-dried into product.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111544319A (en) * | 2020-04-27 | 2020-08-18 | 江苏宝芝林多抗生物工程技术研究有限公司 | Toothpaste capable of inhibiting helicobacter pylori and preparation method thereof |
| CN111643393A (en) * | 2020-07-13 | 2020-09-11 | 幽汰(福建)大健康产业有限公司 | Oral toothpaste for inhibiting helicobacter pylori and preparation device thereof |
| CN111759773A (en) * | 2020-08-13 | 2020-10-13 | 福州幽力克生物科技有限公司 | Toothpaste capable of inhibiting helicobacter pylori and preparation method thereof |
| CN114073764A (en) * | 2020-08-19 | 2022-02-22 | 江苏安泰生物技术有限公司 | Toothpaste capable of efficiently inhibiting helicobacter pylori, preparation method and application thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111544319A (en) * | 2020-04-27 | 2020-08-18 | 江苏宝芝林多抗生物工程技术研究有限公司 | Toothpaste capable of inhibiting helicobacter pylori and preparation method thereof |
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| CN111759773A (en) * | 2020-08-13 | 2020-10-13 | 福州幽力克生物科技有限公司 | Toothpaste capable of inhibiting helicobacter pylori and preparation method thereof |
| CN114073764A (en) * | 2020-08-19 | 2022-02-22 | 江苏安泰生物技术有限公司 | Toothpaste capable of efficiently inhibiting helicobacter pylori, preparation method and application thereof |
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