CN1565551A - Chinese traditional medicine for treating oral disease and its preparing process - Google Patents
Chinese traditional medicine for treating oral disease and its preparing process Download PDFInfo
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Abstract
The invention relates to a traditional Chinese preparation for treating oral diseases and process for preparation, wherein the preparation is prepared from Chinese medicinal herbs including honeysuckle flower, cape jasmine, flavescent sophora root, cnidium fruit, mentha, baikal skullcap root, corktree bark, oriental wormwood, grassleaved sweetflag rhizome, pubescent angelica root, Chinese mugwort leafmulberry leaf, broom cypress fruit.
Description
Affiliated technical field: the invention belongs to Chinese medicine and preparation field thereof, specifically is a kind of Chinese medicine for the treatment of oral disease and preparation method thereof.
Background technology: the relevant statistical inquiry that Chinese dentist association delivers shows: oral disease is that China is ill most populous, sickly plants the disease kind that coverage rate is the widest and morbidity property is the strongest.China has 90% above population to suffer from various oral diseases approximately.The sick kind relates to periodontitis, gingivitis, pulpitis, bacterial plaque on stomatocace, dental neuritis, toothache, the tooth, the variable color of dentine pigmentation (tooth Huang, tooth are black, cigarette stain, tea stain on the tooth) and dental calculus, tens of kinds of tartar etc., and how sick concurrent person accounts for sufferer crowd's majority.When suffering from periodontitis, gingivitis, often also have pigmentation on the tooth, diseases such as bacterial plaque and dental calculus as the patient.Medical circle is generally recognized, general exist actually like this, be far from and depend merely on the medical treatment medication and can solve, can not only can overcome by propaganda oral hygiene general knowledge, and can only seek a kind of can the prevention, the daily oral cavity that can the treat multiple oral disease again health promoting product of keeping a public place clean offers consumers in general widely, just can make this exist actually change.Simultaneously, along with growth in the living standard, the increasing of doings, people pursue the needs that improve oneself more to beautifying self, also grow with each passing day, and this has also proposed requirement to seeking the said goods on the other hand.
The Chinese and western medical healthcare worker is in order to satisfy the living needs that consumer improves constantly both at home and abroad, successively developed all kinds of oral cavities health promoting product of keeping a public place clean, as medicated toothpaste, fragrant mouthful liquid, mouth cleaner or the like, the Western medicine product is used hibitane more, sodium fluoride, metronidazole etc., antiinflammatory in treatment dental pulp periapical, sterilization and flushing aspect, what use at present both at home and abroad also mostly is the chemical classes material, as formaldehyde cresol formocresol, phenol camphor, thymol, phenol such as kreosol and eugenol agent class medicine, mostly there is certain toxic and side effects in these medicines, as have immunogenicity, cytotoxicity or stimulation etc.Because people have a kind of fear to the side effect of Western medicine always, yearn for " back to nature ", be badly in need of using formulated oral health products of natural plants and root canal irrigation, disinfectant preparation, the oral cavity health preparation of exploitation pure Chinese medicinal preparation is significant.
The objective of the invention is the needs according to social reality, for people provide a kind of clearing away heat-fire detoxifcation of having, expelling wind and removing dampness is warded off the Chinese medicine and preparation method thereof of the treatment oral disease of dirty effect.
The objective of the invention is to realize by following technical proposals.
Summary of the invention: the present invention is the Chinese medicine of treatment oral disease, and main raw material by following formulation by weight: Flos Lonicerae 7-21 part, Fructus Gardeniae 1-7 part, Radix Sophorae Flavescentis 1-6 part, Fructus Cnidii 1-6 part, Herba Menthae 8-24 part, Radix Scutellariae 4-12 part, Cortex Phellodendri 3-9 part, Herba Artemisiae Scopariae 3-9 part, Rhizoma Acori Graminei 1-6 part are processed into gargarism, tablet, granule, aerosol, spray, powder.
In the above-mentioned raw materials, can also add Radix Angelicae Pubescentis 1-6 part and/or Folium Artemisiae Argyi 1-6 part and/or Fructus Kochiae 3-9 part.
The preparation method of Chinese medicine of treatment oral disease of the present invention is above-mentioned primary crude drug to be mixed decoct, and each 100kg medical material adds the drinking water of 1000L approximately, boil after for the first time soaking 30min, decoct each 45～70 minutes three times, collect volatile oil simultaneously, get medicinal liquid; Be equivalent to crude drug 2g with being concentrated into every 1ml medicinal liquid with the energy-conservation concentrator of triple effect behind the medical filtration, put coldly, add the remove impurity of ethanol precipitate with ethanol, stir evenly, place 20～30h and filter, behind the filtrate recycling ethanol, add Aromatic water and an amount of adjuvant, water is mixed with gargarism.
Technical scheme of the present invention is the needs of inventor according to social reality, when analyzing similar products at home and abroad extensively and profoundly, in conjunction with Chinese medical theory and clinical experience, the oral cavity health preparation of a kind of pure Chinese medicinal preparation of developing, have another name called " the clean gum gargarism of golden Cape jasmine ", to satisfy the needs that consumers in general prevent and treat oral disease.Motherland's medical science think " the bright large intestine arteries and veins of hands sun is gone in the lower tooth ..., the stomach of foot Yang Ming arteries and veins goes into to go up in the tooth " (a Ling Shu Miraculous Pivot or Divine Axis passages through which vital energy circulates piece of writing) tooth and lung stomach belong to together in, the part of the body cavity above the diaphragm housing the heart and lungs.The ability to speak words have into Shui Gu, distinguish the five tastes, go out functions such as voice, belong to stomach system.The ability to speak words interrelate by meridians and internal organs, and are wherein particularly close with the relation of lung spleen, stomach, the heart, kidney, liver.Visceral dysfunction, exopathogen is invaded, and can both cause ability to speak words generation disease.Visceral dysfunction, many duties in spleen, stomach, the heart, kidney, liver, exopathogen invade many based on wind, heat, cold, wet.Therefore many on method of treatment is its well-established law with heat-clearing and toxic substances removing, expelling wind and removing dampness, holds concurrently with the kidney invigorating and essence nourishing, benefiting qi and nourishing blood.Multiple inflammation such as clinical common gingivitis, periodontitis, pulpitis and periapical periodontitis, red swelling of gingiva, tooth pain appear, many and wind heat invasion and attack, heresy are gathered gingiva, venation block is relevant, dry mouth and parching tongue, gums fester (as periodontal abscess, atrophic periodontitis etc.) how because of heat in the stomach, follow and attack on the Yangming Channel arteries and veins, smoke due to the oral cavity of burning.Dispute is festered, red and swollen causalgia, and the xerostomia halitosis, how because of dysfunction of the spleen in transportation, the damp-stagnancy heat-transformation, or functioning of bladder is not normal, damp and hot gathering, and last steaming is smoked bright oral cavity and is caused.In a word, common clinically oral disease, how because of the wind heat invasion and attack, the pyretic toxicity fire-transformation, damp and hot gather or the damp-stagnancy heat-transformation due to, so dispelling wind and heat pathogens, removing toxic substances and promoting subsidence of swelling, expelling wind and removing dampness, eliminating damp-heat are its main method in the treatment.
Prescription of the present invention cures mainly oral disease, is that to have a liking for food again pungent because of innate excessive fire in the stomach, or wind-heat evil toxin invasion and attack, attacks the oral cavity on the priming retention of heat in the spleen and stomach and causes that it is controlled also based on heat clearing away.In the prescription of the present invention: Flos Lonicerae, property is sweet cold, goes into lung, the heart, stomach warp, and the merit amount of heat clearing away is flood energetically, is longer than heat-clearing and toxic substances removing, wind-heat dissipating, so be we's monarch drug.Fructus Gardeniae in the side, the property bitter cold can be gone into the heart, lung, three warmers passages through which vital energy circulates, kind pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, Herba Menthae, property is hot cool, lightly floats into lung, and wind and heat dispersing is sent out stagnated fire more, and the pyretic toxicity of the stomach of relieving boredom clearly helps the principal agent heat-clearing and toxic substances removing, and fragrance is kept away dirty; Assistant is with the pyretic toxicity of the clear middle part of the body cavity above the diaphragm housing the heart and lungs of Radix Scutellariae, and the clear damp-heat in lower-JIAO of Cortex Phellodendri, Radix Sophorae Flavescentis clear away the dampness and heat wet fiery double with wind dispelling insecticide, help principal agent to remove the pyretic toxicity of three warmers altogether, are we's ministerial drug." Waike Zhengzong, Orthodox Manual of External Diseases " said: " the tooth patient has wind, and fire is arranged, and also has sun bright damp and hot, all can cause it ".So we are damp and hot with Herba Artemisiae Scopariae, the clear sharp liver spleen bladder of the Fructus Kochiae; Rhizoma Acori Graminei removing dampness expectorant has one's ideas straightened out that it is dirty to keep away, and helps the merit of its principal agent clearing heat and expelling damp, is adjuvant drug altogether.The current QI and blood of Radix Angelicae Pubescentis in the side, expelling wind and dampness; The damp eliminating of Folium Artemisiae Argyi fragrance, analgesic hemostatic: Fructus Cnidii dispeiling pathogenic wind and removing dampness; Amount to and remove the wind damp eliminating, fragrance is kept away dirty merit, can help the property of the our bitter cold of system simultaneously again, robs the fraud of the moon, makes it medicine for assistant altogether.More than all medicines share, inside and outside double executing brought out the best in each other, and makes the wet burning hot poison of taste be able to Qinghua.
In sum, the clean gum gargarism of product gold Cape jasmine of the present invention medicine machine agrees with, with cold medicine is main clearing away heat-fire detoxifcation, and it is dirty to be with warm medicine that auxilliary expelling wind and removing dampness is kept away, and clinical test results shows, evident in efficacy to oral disease because of hot person, and this medicine directly acts on the affected part, collection antiinflammatory, pain relieving, sterilization, heat clearing away, detoxifies, pacifies and be one, safety non-toxic, control takes into account, and can be used as the another pharmaceutical preparations of family's oral cavity health and clinical treatment.Pharmacodynamic study shows that the clean gum of product gold Cape jasmine of the present invention is very strong to the oral cavity pathogen bacteriostasis, very little to the effect of G+ coccus, life-time service can keep the oral cavity microecological balance, compares with other synthetic drugs, having more the outstanding advantage that efficiently has no side effect, also is the present invention's advantage place.
Product function of the present invention cures mainly and is the clearing away heat-fire detoxifcation, and expelling wind and removing dampness is warded off dirty, is used for the tooth pain that causes because of retention of heat in the spleen and stomach or wind heat invasion and attack, be paroxysmal, chance wind outbreak, coldly then subtract red swelling of gingiva or go out pus and blood, thirsty, implication is smelly dirty, and constipation is dry and hard, red tongue with yellow fur, diseases such as rapid pulse, and periodontitis, pericoronitis, the oral ulcer person that sees the above-mentioned symptom.
Product forms of the present invention has gargarism, tablet, aerosol, spray, powder, granule.Name of product of the present invention can be " the clean gum of golden Cape jasmine ".
The invention is further illustrated by the following examples, and the present invention is not limited only to described embodiment.
The specific embodiment:
Embodiment one
15 parts of extracting honeysuckles, 4 parts of Fructus Gardeniaes, 4 parts of Radix Sophorae Flavescentiss, 4.5 parts of Fructus Cnidiis, 16 parts of Herba Menthaes, 8 parts of Radix Scutellariaes, 6 parts of Cortex Phellodendris, 6 parts of Herba Artemisiae Scopariaes, 4 parts of Rhizoma Acori Graminei, above-mentioned primary crude drug mixture is decocted, each 100kg medical material adds the drinking water of 1000L approximately, boil after for the first time soaking 30min, decoct three times, each 45～70 minutes, collect volatile oil simultaneously, getting medicinal liquid 200 mesh sieves filters with the energy-conservation concentrator of triple effect concentrated, 80 ℃ of one effect temperature, two 70 ℃ of effects, triple effect are concentrated into relative density 1.10～1.18 for 60 ℃, get clear paste; Get the powder process of moiety clear paste spray drying, 160～180 ℃ of inlet temperature, 80～100 ℃ of leaving air temps get extract powder; Remaining second half clear paste and extract powder are granulated with one-step-granulating method, and 60～80 ℃ of inlet temperature, 45～70 ℃ of leaving air temps make granule, add above-mentioned volatile oil, and mixing is distributed into 4000 bags, every bag of 5g.
Embodiment two
8 parts of extracting honeysuckles, 2 parts of Fructus Gardeniaes, 2.5 parts of Radix Sophorae Flavescentiss, 1.5 parts of Fructus Cnidiis, 9 parts of Herba Menthaes, 5 parts of Radix Scutellariaes, 4 parts of Cortex Phellodendris, 4 parts of Herba Artemisiae Scopariaes, 2 parts of methods of pressing embodiment one of Rhizoma Acori Graminei, add the proper amount of lubricating agent tabletting again after making granule, 0.48～0.52g/ sheet, make with the high-efficiency coating machine coating, inspect, get the tablet product by ready samples.
Embodiment three
4.5 parts of 18 parts of extracting honeysuckles, 6 parts of Fructus Gardeniaes, 5 parts of Radix Sophorae Flavescentiss, 5 parts of Fructus Cnidiis, 20 parts of Herba Menthaes, 10 parts of Radix Scutellariaes, 8 parts of Cortex Phellodendris, 7.5 parts of Herba Artemisiae Scopariaes, Rhizoma Acori Graminei decoct above-mentioned primary crude drug mixture, each 100kg medical material adds the drinking water of 1000L approximately, boil after for the first time soaking 30min, decoct three times, each 45～70 minutes, collect volatile oil simultaneously, get medicinal liquid; Be concentrated into every 1ml medicinal liquid with the energy-conservation concentrator of triple effect after reuse 200 mesh sieves filter and be equivalent to crude drug 2g, put cold, the ethanol precipitate with ethanol remove impurity that adds an amount of (medicinal liquid contains the about 50-70% of alcohol amount), stir evenly, place 20～30h and filter, behind the filtrate recycling ethanol, filtrate adds Aromatic water and appropriate amount of auxiliary materials, water is mixed with gargarism, is distributed into 10000 bottles, every bottle of 150ml.
Embodiment four
18 parts of extracting honeysuckles, 3.5 parts of Fructus Gardeniaes, 4 parts of Radix Sophorae Flavescentiss, 4.5 parts of Fructus Cnidiis, 16 parts of Herba Menthaes, 6 parts of Radix Scutellariaes, 5 parts of Cortex Phellodendris, 6 parts of Herba Artemisiae Scopariaes, 3 parts of methods by embodiment three of Rhizoma Acori Graminei are prepared into gargarism.
Embodiment five
15 parts of extracting honeysuckles, 4 parts of Fructus Gardeniaes, 4 parts of Radix Sophorae Flavescentiss, 4.5 parts of Fructus Cnidiis, 16 parts of Herba Menthaes, 8 parts of Radix Scutellariaes, 6 parts of Cortex Phellodendris, 6 parts of Herba Artemisiae Scopariaes, 4 parts of Rhizoma Acori Graminei, 4 parts of Radix Angelicae Pubescentiss, 4 parts of Folium Artemisiae Argyis, 5 parts of the Fructus Kochiae are made the granule product by the method for example one.
Embodiment six
10 parts of extracting honeysuckles, 3 parts of Fructus Gardeniaes, 4.5 parts of Radix Sophorae Flavescentiss, 3.5 parts of Fructus Cnidiis, 9 parts of Herba Menthaes, 5 parts of Radix Scutellariaes, 5 parts of Cortex Phellodendris, 4 parts of Herba Artemisiae Scopariaes, 2 parts of Rhizoma Acori Graminei, 5 parts of Radix Angelicae Pubescentiss, 3 parts of Folium Artemisiae Argyis, 6 parts of the Fructus Kochiae, press the method for embodiment one, add the proper amount of lubricating agent tabletting again after making granule, 0.48～0.52g/ sheet, use the high-efficiency coating machine coating, inspect, get the tablet product by ready samples.
Embodiment seven
12 parts of extracting honeysuckles, 5 parts of Fructus Gardeniaes, 3 parts of Radix Sophorae Flavescentiss, 5 parts of Fructus Cnidiis, 15 parts of Herba Menthaes, 7 parts of Radix Scutellariaes, 4.5 parts of Cortex Phellodendris, 7 parts of Herba Artemisiae Scopariaes, 4 parts of Rhizoma Acori Graminei, 3 parts of Radix Angelicae Pubescentiss, 4 parts of Folium Artemisiae Argyis, 7 parts of the Fructus Kochiae, above-mentioned primary crude drug mixture is decocted, each 100kg medical material adds the drinking water of 1000L approximately, boil after for the first time soaking 30min, decoct three times, each 45～70 minutes, collect volatile oil simultaneously, get medicinal liquid; Be concentrated into every 1ml medicinal liquid with the energy-conservation concentrator of triple effect after reuse 200 mesh sieves filter and be equivalent to crude drug 2g, put cold, the ethanol precipitate with ethanol remove impurity that adds an amount of (medicinal liquid contains the about 50-70% of alcohol amount), stir evenly, place 20～30h and filter, behind the filtrate recycling ethanol, add Aromatic water and appropriate amount of auxiliary materials, water is mixed with spray, is distributed into 25000 bottles, every bottle of 60ml.
In addition, also can be by the preparation method of embodiment one, embodiment two, embodiment three, in its prescription, add any one or two kinds (adding) in Radix Angelicae Pubescentis, Folium Artemisiae Argyi, the Fructus Kochiae, can obtain required product, do not provide one by one at this by aforementioned formula ratio scope of giving.
The present invention also can make powder, aerosol etc. according to a conventional method.
Further specify beneficial effect of the present invention below by clinical data.
Product treatment gingivitis, periodontitis and pericoronitis clinical verification situation of the present invention:
Gingivitis, periodontitis and intact Zhou Yan are the modal inflammation in oral cavity, often cause symptoms such as pain, swelling, hemorrhage and halitosis.In order to observe the therapeutical effect of product of the present invention to these inflammation and symptom, we have done 98 routine clinical verifications, and its result is as follows:
1, test method
1.1 study subject: include this clinical trial totally 98 examples in, male 46 people, women 52 people, the age 19 is to 71 years old, average 38 years old.
40 examples are arranged for West China stomatological hospital oral medicine outpatients among the experimenter, 53 examples are done colony and are observed in gingivitis that the generaI investigation of Chengdu rubber two factories filters out, periodontitis, pericoronitis patient in addition.No systemic disease and do not obey antibacterials in January.
Outpatient service and colony observe the case inflammation and distribute: gingivitis 57.1%, periodontitis 33.7%, pericoronitis 9.2%.
1.2 grouping situation: adopt random method grouping and double-blind method to test in proper order according to prescription on individual diagnosis.Test group 76 people (40 people are observed in outpatient service, 36 people of colony).Matched group 22 people are colony and observe.Two groups of medication preconditions equate (table 1, table 2) substantially.
Main suit's symptom of test group and matched group before table 1 medication
Symptom test group (n=76) matched group (n=22)
Routine number % occurs and routine number % occurs
Red and swollen 58 76.3 8 36.4
Pain 59 77.6 8 36.4
Hemorrhage 63 82.9 18 82.8
Halitosis 35 46.1 7 31.8
The average index of test group and matched group before table 2 medication
Index project test group matched group
GI 1.73±0.44 1.53±0.40
BI 1.03±0.35 0.93±0.22
PD 1.85±0.58 1.58±0.58
1.3 mouth-wash medicine and method
Test group medicine: the clean gum gargarism of golden Cape jasmine.
The matched group medicine: refined bodyguard collutory, by the explanation preparation.Pack the same with test group.
Gargle each 10ml rinsing the mouth 1 minute every day three times.Gingivitis patients is only gargled, periodontitis, pericoronitis patient except that gargling, when checking at every turn with same medicine liquid washing periodontal pocket of 10ml or blind bag.Diet and hygienic habit are not used other collutory as usual during the medication, except that serious case, generally do not give antibiotic.
Be 10 days the whole course of treatment, checks altogether three times, that is: (the 10th day) looked in preliminary investigation, check (the 5th day) eventually.Three inspections are finished by same hospital, and the record of filling in a form strictly according to the facts.
1.4 nacterial smear and bacterial plaque inspection method: nacterial smear and is used congo red staining, microscopy respectively before the preliminary investigation medication and check or sampling when looking into eventually.The bacterial plaque inspection is observed after adopting plaque disclosing agent (algae is red) dyeing.
Participate in this checking and finished the experimenter of test overall process, test group has 86%, and matched group has 82%, and all the other have been finished and have tested course of treatment of 2/3.Therefore, the effectiveness of this clinical verification is reliable.
The result evaluation standard is seen the operation instruction of filling in a form.
2 result of the tests
The situation (table 3) of the improvement of back main suit symptom 2.1 gargle
The comparison (%) of main suit's doing well,improving after table 3 is gargled
It is invalid that disease disappearance alleviates
Shape test group matched group test group matched group test group matched group P
Red and swollen 55.6 25.0 44.4 75.0 00＜0.001
Pain 72.1 25.0 27.9 75.0 00＜0.001
Hemorrhage 68.6 50.0 29.4 45.0 1.96 5.0＜0.02
Halitosis 42.9 14.0 53.4 86.0 3.6 0＜0.001
Table 3 result displayed explanation, adopt the clean gum gargarism of golden Cape jasmine after, though what difference its total effective rate of effect such as its pain relieving, detumescence, hemostasis, antihalitosis and refined bodyguard group do not have, statistics shows that the former disappearance rate ratio is far above the latter.
Back several the index variation situations (table 4,5,6) 2.2 gargle
Except that depth of pocket changed not quite, all other had decline significantly as average indexs such as GI, BI, PI, and the difference of front and back has highly significant.By contrast, the percentage ratio that average index descended after the clean gum gargarism of golden Cape jasmine was gargled is obviously greater than refined bodyguard group.
The variation of (Outpatient Unit) average index after the clean gum gargarism of table 4 gold Cape jasmine is gargled
Reduction rate % P after the medication before the inspection item medication
GI 2.52±0.62 0.82±0.98 67.46 ＜0.01
BI 2.18±0.56 0.45±0.64 79.36 ＜0.001
PDI 5.94±2.51 5.02±2.40 15.49 ＞0.05
The variation of (population groups) average index after the clean gum gargarism of table 5 gold Cape jasmine is gargled
Reduction rate % P after the medication before the inspection item medication
GI 1.73±0.44 0.51±0.47 70.40 ＜0.001
BI 1.03±0.35 0.26±0.34 74.39 ＜0.001
PI 1.85±0.58 1.29±0.42 30.20 ＜0.05
PDI 5.0 4.4 12.0 ＞0.05
The variation of average index after the refined bodyguard of table 6 is gargled
Reduction rate % P after the medication before the inspection item medication
GI 1.58±0.40 2.71±0.47 55.06 ＜0.001
BI 0.93±0.22 0.41±0.39 55.91 ＜0.001
PDI 1.86±0.58 1.35±0.49 27.42 ＜0.05
The variation of above-mentioned average index is test group or matched group no matter, all has along with gargling time lengthening and the continuous trend of reductions, and the 10 days average indexes of gargling are apparent to be lower than 5 days.This shows, through the clean gum gargarism of golden Cape jasmine rinsing the mouth commonly used, more can effectively control oral inflammation.
2.3 the result of Congo red smear bacterioscopy: see Table 7
The variation of antibacterial ratio of components before and after the medication of the clean gum gargarism of table 7 gold Cape jasmine
Bacterial species detects before the routine number medication reduction rate % P after the medication
Spirillum 21 10.86 ± 8.01 4.19 ± 5.45 61.42＜0.001
Bacillus 22 38.41 ± 20.2 23.80 ± 19.2 47.41＜0.001
Coccus 22 51.91 ± 21.58 71.91 ± 19.9 rise 27.8＞0.1
Table 7 shows the relevant pathogenic bacterium of periodontitis after clean gum gargarism is gargled with golden Cape jasmine, and percentage composition is than significantly reducing, and irrelevant bacterium such as coccus percentage ratio rise on the contrary, the trend of this variation after medication preceding 5 days more obvious, change not quite after 5 days.
2.4 total effects evaluation (table 8)
Table 8 test group and matched group therapeutic evaluation %
Group produce effects enabledisable total effective rate
Test group 64.5 34.2 1.3 98.7
Matched group 45.0 50.0 5.0 95.0
P＜0.005
Table 8 statistics show that although test group and matched group total effective rate are comparatively approaching, the former obvious effective rate is significantly higher than the latter.
2.5 sensory issues (table 9)
Experimental observation finds that 88.9% people can accept the clean gum gargarism of golden Cape jasmine mouthfeel, a little less than refined bodyguard group (94.5%).The uncomfortable people of the clean gum gargarism of golden Cape jasmine mouthfeel reaction is thought that mainly the Chinese medicine bitterness exists.
The mouthfeel of table 9 liang group collutory is (%) relatively
Clean refreshing comfortable general discomfort
Test group 61.1 27.8 11.1
Matched group 54.5 40.0 5.5
2.6 side effect
After 11% the clean gum gargarism of human gold Cape jasmine is gargled numb sensation is arranged, the whole test group only finds that an example has mucosal burning sensation, does not have tooth dyeing and other toxic and side effects.
3, brief summary
Finish clinical verification 98 examples altogether, test group 76 people, matched group 22 people.Checking is the result show:
3.1 the total effective rate of antiinflammatory and controlling symptoms, the clean gum gargarism of golden Cape jasmine group 98.7%, refined bodyguard group 95%.The two difference is little.But from obvious effective rate, the former (64.5%) is significantly higher than latter's (45%), P＜0.005
According to main suit's symptom (pain, redness, hemorrhage and halitosis) and several indexes (GI, BI, PI) variation carrying out Comprehensive Assessment, difference all has remarkable statistical significance before and after gold Cape jasmine clean gum gargarism group and the test of refined bodyguard group, show that these two kinds of medicinal liquids all have the good curing effect, but the degree to doing well,improving is seen, the clean gum gargarism of gold Cape jasmine obviously is better than refined bodyguard group, and the clean gum gargarism of golden Cape jasmine of Types of Medicine was more optimistic at the refined bodyguard collutory that the effect aspect oral health-care product and auxiliary treatment contains metronidazole during this prompting was pure.
3.2 can significantly reduce periodontal disease pathogenic bacterium in the oral cavity after the clean gum gargarism of golden Cape jasmine is gargled, make spirillum percentage ratio reduce by 61.42%, bacillus reduces by 47.41%, the coccus ratio then correspondingly rises 27.8%, this shows that this medicine can effectively suppress and kill oral cavity pathogen, and little to the normal flora influence.
3.3 the mouthfeel of the clean gum gargarism of golden Cape jasmine is subjected to and can be accepted by 89% people, a little less than refined bodyguard group (95%).Mainly be that a few peoples do not feel like oneself to a little the Chinese medicine hardship that keeps.
Use the clean gum gargarism of golden Cape jasmine to gargle and do not produce obvious toxic-side effects.
Claims (3)
1, a kind of Chinese medicine for the treatment of oral disease, it is characterized in that main raw material by following formulation by weight: Flos Lonicerae 7-21 part, Fructus Gardeniae 1-7 part, Radix Sophorae Flavescentis 1-6 part, Fructus Cnidii 1-6 part, Herba Menthae 8-24 part, Radix Scutellariae 4-12 part, Cortex Phellodendri 3-9 part, Herba Artemisiae Scopariae 3-9 part, Rhizoma Acori Graminei 1-6 part are refined into gargarism, tablet, granule, aerosol, spray, powder by each dosage formulation requirement.
2, the Chinese medicine of treatment oral disease according to claim 1 is characterized in that also can adding in the described raw material Radix Angelicae Pubescentis 1-6 part and/or Folium Artemisiae Argyi 1-6 part and/or Fructus Kochiae 3-9 part.
3, the preparation method of Chinese medicine of treatment oral disease according to claim 1 is characterized in that it being that the primary crude drug mixture is decocted, and adds drinking water, boil after soaking for the first time, decoct each 45～70 minutes three times, collect volatile oil simultaneously, get medicinal liquid; Cold with concentrating, put with concentrator behind the medical filtration, add the remove impurity of ethanol precipitate with ethanol, stir evenly, place 20～30h and filter, behind the filtrate recycling ethanol, add Aromatic water and appropriate amount of auxiliary materials, water is mixed with gargarism.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100420432C (en) * | 2006-08-25 | 2008-09-24 | 青岛大学医学院附属医院 | Gargle and its preparing process |
| CN100531761C (en) * | 2006-01-10 | 2009-08-26 | 贵州环宇药业有限公司 | Traditional Chinese medicine spray for washing and taking-care of nasal cavity |
| CN102293725A (en) * | 2011-08-19 | 2011-12-28 | 哈尔滨医科大学 | Manufacture process for gargle used for oral cavity cleanness |
| CN102600287A (en) * | 2012-03-22 | 2012-07-25 | 李翠荣 | Compound medicine for treating toothache |
| CN102895383A (en) * | 2012-10-26 | 2013-01-30 | 施瑞客（天津）生物技术有限公司 | Traditional Chinese medical composition for treatment of cat ringworm |
| CN103550656A (en) * | 2013-11-10 | 2014-02-05 | 孙丽美 | Traditional Chinese medicine preparation for treating toothache |
| CN105770658A (en) * | 2016-05-17 | 2016-07-20 | 上饶市莎江高科生物有限公司 | Traditional Chinese medicine preparation for treating oral disease |
| CN111529604A (en) * | 2020-06-01 | 2020-08-14 | 蔡超东 | Traditional Chinese medicine external medicament for treating toothache |
-
2003
- 2003-06-18 CN CN 03135226 patent/CN1234389C/en not_active Expired - Lifetime
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100531761C (en) * | 2006-01-10 | 2009-08-26 | 贵州环宇药业有限公司 | Traditional Chinese medicine spray for washing and taking-care of nasal cavity |
| CN100420432C (en) * | 2006-08-25 | 2008-09-24 | 青岛大学医学院附属医院 | Gargle and its preparing process |
| CN102293725A (en) * | 2011-08-19 | 2011-12-28 | 哈尔滨医科大学 | Manufacture process for gargle used for oral cavity cleanness |
| CN102293725B (en) * | 2011-08-19 | 2012-09-26 | 哈尔滨医科大学 | Manufacture process for gargle used for oral cavity cleanness |
| CN102600287A (en) * | 2012-03-22 | 2012-07-25 | 李翠荣 | Compound medicine for treating toothache |
| CN102895383A (en) * | 2012-10-26 | 2013-01-30 | 施瑞客（天津）生物技术有限公司 | Traditional Chinese medical composition for treatment of cat ringworm |
| CN103550656A (en) * | 2013-11-10 | 2014-02-05 | 孙丽美 | Traditional Chinese medicine preparation for treating toothache |
| CN103550656B (en) * | 2013-11-10 | 2014-07-09 | 孙丽美 | Traditional Chinese medicine preparation for treating toothache |
| CN105770658A (en) * | 2016-05-17 | 2016-07-20 | 上饶市莎江高科生物有限公司 | Traditional Chinese medicine preparation for treating oral disease |
| CN105770658B (en) * | 2016-05-17 | 2020-02-14 | 上饶市莎江高科生物有限公司 | Chinese medicinal preparation for treating oral diseases |
| CN111529604A (en) * | 2020-06-01 | 2020-08-14 | 蔡超东 | Traditional Chinese medicine external medicament for treating toothache |
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| Publication number | Publication date |
|---|---|
| CN1234389C (en) | 2006-01-04 |
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