CN105770658B - Chinese medicinal preparation for treating oral diseases - Google Patents
Chinese medicinal preparation for treating oral diseases Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/355—Lonicera (honeysuckle)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/904—Stemonaceae (Stemona family), e.g. croomia
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a traditional Chinese medicine preparation for treating oral diseases, which comprises the following raw materials: the Chinese medicinal preparation is aqueous spray prepared from pure Chinese medicinal herbs, and has the advantages of convenience in carrying and use, no side effect, safety, reliability and good curative effect.
Description
Technical Field
The invention relates to a traditional Chinese medicine preparation for treating oral diseases, belonging to the field of medicines.
Background
Oral cavity, tooth, throat, ear diseases of human body are common diseases, usually caused by bacterial infection and virus, if not treated in time, not only affect normal work, but also are related to life safety and danger. At present, the common treatment methods in the market and hospitals are injection and inflammation diminishing or western medicine taking. The method requires time for seeing a doctor and has side effects of western medicines, even if the powder is taken, the throat is easy to choke, and the effect is not reliable, and the product is changed into a product suitable for mouth sticking, so that the allergy is easy to generate.
Disclosure of Invention
The invention aims to provide a Chinese medicinal preparation for treating oral diseases, which is water spray extracted from pure Chinese medicinal herbs, is convenient to carry and use, has no side effect, and is safe and reliable and good in curative effect.
A traditional Chinese medicine preparation for treating oral diseases is prepared from the following traditional Chinese medicine raw materials in parts by mass: 8-30 parts of verbena, 2-10 parts of garlic, 0.5-15 parts of achyranthes, 10-50 parts of radix stemonae, 8-30 parts of purslane, 6-25 parts of fig, 1-10 parts of angelica dahurica, 5-25 parts of perfoliate knotweed herb, 6-30 parts of radix sophorae flavescentis, 3-10 parts of polygonum cuspidatum, 0.5-10 parts of wild chrysanthemum, 3-20 parts of houttuynia cordata, 0.8-40 parts of honeysuckle, 0.5-0.8 part of subprostrate sophora, 0.7-8 parts of white mulberry root-bark, 0.5-18 parts of black nightshade, 0.5-8 parts of bitter almond, 0.5-30 parts of solidago decurrens and 0.6-10 parts of cyrtomium rhizome.
A Chinese medicinal preparation for treating oral diseases is prepared by the following steps: placing the above raw materials in an extraction tank, adding 100 and 200 parts of distilled water, heating and extracting at 80-90 ℃ for 40-80 minutes, filtering, concentrating the filtrate to 1/2-2/3 of the original volume, finely filtering, adding 0.1-0.5 part of borneol and 0.1-0.5 part of potassium sorbate, and filling to obtain the product.
A Chinese medicinal preparation for treating oral diseases is prepared by the following steps: directly spraying or pouring into oral cavity or throat, and spraying for 3-4 times daily.
A Chinese medicinal preparation for treating oral diseases is used for treating oral ulcer, periodontitis and gingivitis, and is administered by being swallowed or spitted in mouth 10-15 min later.
A Chinese medicinal preparation for treating oral diseases, pharyngolaryngitis, tonsillitis, and cough, is divided into several times for swallowing, and is taken after half an hour.
The invention can treat diseases such as oral ulcer, periodontitis, gingivitis, pharyngolaryngitis, tonsillitis, otitis media, cough and the like, is prepared from pure Chinese herbal medicines, has no toxicity, no side effect, safety, reliability, quick curative effect, good effect, rich resources, low cost, large profit, simple preparation, no pollution to the environment and no public nuisance, is a genuine green product, and has great practical significance for solving the problems of difficult and expensive medical care.
The specific embodiment is as follows:
example 1:
a traditional Chinese medicine preparation for treating oral diseases is prepared from the following traditional Chinese medicine raw materials in parts by mass: 8 parts of verbena, 2 parts of garlic, 0.5 part of achyranthes, 10 parts of radix stemonae, 8 parts of purslane, 6 parts of fig, 1 part of angelica dahurica, 5 parts of perfoliate knotweed, 6 parts of sophora flavescens, 3 parts of polygonum cuspidatum, 0.5 part of wild chrysanthemum flower, 3 parts of houttuynia cordata, 0.8 part of honeysuckle, 0.5 part of subprostrate sophora, 0.7 part of cortex mori, 0.5 part of black nightshade, 0.5 part of bitter almond, 0.5 part of solidago decurrens and 0.6 part of cyrtomium rhizome.
A Chinese medicinal preparation for treating oral diseases is prepared by the following steps: placing the above raw materials in an extraction tank, adding 100 parts of distilled water, heating and extracting at 80 deg.C for 40 min, filtering, concentrating the filtrate to 1/2 of the original volume, fine filtering, adding 0.1 part of Borneolum Syntheticum and 0.1 part of potassium sorbate, and packaging to obtain the final product.
Example 2:
a traditional Chinese medicine preparation for treating oral diseases is prepared from the following traditional Chinese medicine raw materials in parts by mass: 20 parts of verbena, 6 parts of garlic, 8 parts of achyranthes, 30 parts of radix stemonae, 20 parts of purslane, 15 parts of fig, 5 parts of angelica dahurica, 15 parts of perfoliate knotweed herb, 18 parts of radix sophorae flavescentis, 6 parts of giant knotweed, 5 parts of wild chrysanthemum flower, 10 parts of cordate houttuynia, 20 parts of honeysuckle, 0.6 part of subprostrate sophora, 4 parts of white mulberry root-bark, 9 parts of black nightshade, 4 parts of bitter apricot kernel, 15 parts of solidago decurrens and 5 parts of cyrtomium rhizome.
A Chinese medicinal preparation for treating oral diseases is prepared by the following steps: placing the above raw materials in an extraction tank, adding 150 parts of distilled water, heating and extracting at 85 deg.C for 60 min, filtering, concentrating the filtrate to 2/3 of the original volume, fine filtering, adding 0.3 part of Borneolum Syntheticum and 0.3 part of potassium sorbate, and packaging to obtain the final product.
Example 3:
a traditional Chinese medicine preparation for treating oral diseases is prepared from the following traditional Chinese medicine raw materials in parts by mass: 30 parts of verbena, 10 parts of garlic, 15 parts of achyranthes, 50 parts of radix stemonae, 30 parts of purslane, 25 parts of fig, 10 parts of angelica dahurica, 25 parts of perfoliate knotweed herb, 30 parts of radix sophorae flavescentis, 10 parts of giant knotweed, 10 parts of wild chrysanthemum flower, 20 parts of cordate houttuynia, 40 parts of honeysuckle, 0.8 part of subprostrate sophora, 8 parts of white mulberry root-bark, 18 parts of black nightshade, 8 parts of bitter apricot kernel, 30 parts of solidago decurrens and 10 parts of cyrtomium rhizome.
A Chinese medicinal preparation for treating oral diseases is prepared by the following steps: placing the above raw materials in an extraction tank, adding 200 parts of distilled water, heating and extracting at 90 deg.C for 80 minutes, filtering, concentrating the filtrate to 2/3 of the original volume, fine filtering, adding 0.5 part of Borneolum Syntheticum and 0.5 part of potassium sorbate, and filling to obtain the final product.
Example 4:
a traditional Chinese medicine preparation for treating oral diseases is prepared from the following traditional Chinese medicine raw materials in parts by mass: 5 parts of verbena, 15 parts of garlic, 20 parts of achyranthes, 5 parts of radix stemonae, 35 parts of purslane, 5 parts of fig, 15 parts of angelica dahurica, 2 parts of perfoliate knotweed herb, 2 parts of radix sophorae flavescentis, 15 parts of giant knotweed, 15 parts of wild chrysanthemum flower, 25 parts of cordate houttuynia, 0.5 part of honeysuckle, 1 part of subprostrate sophora, 0.5 part of white mulberry root-bark, 20 parts of black nightshade, 10 parts of bitter apricot kernel, 0.2 part of solidago decurrens and 15 parts of cyrtomium rhizome.
A Chinese medicinal preparation for treating oral diseases is prepared by the following steps: placing the above raw materials in an extraction tank, adding 80 parts of distilled water, heating at 70 deg.C for 90 min, filtering, concentrating the filtrate to 1/2 of the original volume, fine filtering, adding 0.8 part of Borneolum Syntheticum and 0.6 part of potassium sorbate, and packaging to obtain the final product.
Example 5:
a traditional Chinese medicine preparation for treating oral diseases is prepared from the following traditional Chinese medicine raw materials in parts by mass: 10 parts of verbena, 5 parts of garlic, 10 parts of achyranthes, 10 parts of purslane, 20 parts of figs, 8 parts of angelica dahurica, 20 parts of perfoliate knotweed herb, 10 parts of radix sophorae flavescentis, 5 parts of giant knotweed, 3 parts of wild chrysanthemum, 10 parts of cordate houttuynia, 15 parts of honeysuckle, 5 parts of white mulberry root-bark, 10 parts of black nightshade, 5 parts of bitter almond and 8 parts of cyrtomium rhizome.
The rest is the same as example 2.
Example 6:
the invention discloses a traditional Chinese medicine formula for treating oral ulcer and a preparation method thereof according to the application number of 201510847836.X, and the invention name is that the traditional Chinese medicine formula comprises the following raw materials in parts by weight: 15 g of gardenia jasminoides, 15 g of scutellaria baicalensis, 30 g of forsythia suspensa, 35 g of mint, 30 g of coptis chinensis, 45 g of podophyllum, 15 g of cinnamon, 35 g of prepared rhizome of rehmannia, 25 g of yam, 25 g of rhizoma alismatis, 25 g of dogwood, 15 g of catalpa pohuanensis and the like, and 500 g of kaoliang spirit. The prepared medicine for treating the oral ulcer.
Animal clinical trials:
animals: 60 Kunming white mice with the weight of 18-22g and half of each sex are divided into 7 groups, each group comprises 10 mice, and the mice are respectively a control group and an example 1-6 group.
Effect on wound healing in rat skin: after anesthetizing the rats with ether, the back was stamped with a 9mm diameter punch dipped with ink and the skin was cut off. Thereafter, the drugs prepared in examples 1 to 6 were applied to wounds in the groups of examples 1 to 6 at a dose of 0.1 ml/dose per day, and the control group was left without drug and the wound area was measured for 15 days, 5 days, 10 days and 15 days.
The results are shown in Table 1.
Table 1 invention pairsEffect of wound healing in rats
The results show that: the medicine prepared in the embodiments 1 to 3 of the invention can promote the healing of wounds, the effect is obviously better than that of the embodiment 4 group (different process parameters), the embodiment 5 group (few traditional Chinese medicine raw materials) and the embodiment 6 group (medicines for treating oral ulcer disclosed in other patents), and the process parameters and the selection of the traditional Chinese medicine raw materials have influence on the curative effect of the prepared medicine, so that the medicine for treating oral diseases with obvious curative effect is prepared by adopting the specific traditional Chinese medicine raw materials and the process parameters.
Claims (1)
1. A traditional Chinese medicine preparation for treating oral ulcer is characterized in that: the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by mass: 20 parts of verbena, 6 parts of garlic, 8 parts of achyranthes, 30 parts of radix stemonae, 20 parts of purslane, 15 parts of fig, 5 parts of angelica dahurica, 15 parts of perfoliate knotweed herb, 18 parts of radix sophorae flavescentis, 6 parts of giant knotweed, 5 parts of wild chrysanthemum, 10 parts of cordate houttuynia, 20 parts of honeysuckle, 0.6 part of subprostrate sophora, 4 parts of white mulberry root-bark, 9 parts of black nightshade, 4 parts of bitter apricot kernel, 15 parts of solidago decurrens and 5 parts of cyrtomium fortunei;
the preparation process comprises the following steps: placing the above raw materials in an extraction tank, adding 150 parts of distilled water, heating and extracting at 85 deg.C for 60 min, filtering, concentrating the filtrate to 2/3 of the original volume, fine filtering, adding 0.3 part of Borneolum Syntheticum and 0.3 part of potassium sorbate, and packaging to obtain the final product.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610326947.0A CN105770658B (en) | 2016-05-17 | 2016-05-17 | Chinese medicinal preparation for treating oral diseases |
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| CN201610326947.0A CN105770658B (en) | 2016-05-17 | 2016-05-17 | Chinese medicinal preparation for treating oral diseases |
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| CN105770658B true CN105770658B (en) | 2020-02-14 |
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Families Citing this family (2)
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| CN106511471B (en) * | 2016-11-30 | 2019-11-22 | 浙江省林业科学研究院 | A kind of fig oral spray and preparation method thereof |
| CN112546152A (en) * | 2021-01-18 | 2021-03-26 | 李垂养 | A Chinese medicinal composition for treating oral and throat diseases, and its spray preparation method |
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