CN103191418B - Buccal patch for treating dental ulcer by combination of internal and external treatments - Google Patents
Buccal patch for treating dental ulcer by combination of internal and external treatments Download PDFInfo
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Abstract
The invention relates to a buccal patch for treating dental ulcer by combination of internal and external treatments. The patch comprises a biological cellulose layer and a sugar-coating layer which coats the biological cellulose, wherein the biological cellulose layer comprises medicinal components or active components capable of externally treating dental ulcer; and the sugar-coating layer comprises medicines or active components capable of internally treating dental ulcer. When the patch is used, the external sugar coating is dissolved firstly to release the medicines or active components capable of internally treating the dental ulcer, so that an internal treatment effect is played when a patient takes the patch; and along with dissolution of the sugar coating, the biological cellulose film is exposed, and the patch is applied to the ulcer position to slowly release the medicines or active components capable of externally treating dental ulcer to play the effect of external treatment. The buccal patch can be used for treating dental ulcer by combination of internal and external treatments, which means that the ulcer wound can be sterilized and disinfected and the wound healing can be accelerated; and the buccal patch can be used for regulating endocrine and improving the immunity, so that the repeated relapse of dental ulcer can be avoided.
Description
Technical field
The present invention relates to a kind of paster of sucking, particularly relate to a kind of paster of sucking for the treatment of of the inside combined with the outside treatment oral ulcer.
Background technology
Oral ulcer (oral ulcer, OU), is called again " aphtha ", is a kind of common oral mucosa disease, is that the integrity generation persistence of oral mucosa epithelium is damaged or destroy, superficial necrosis the form depression that comes off.The cause of disease is comparatively complicated, may with mucosal epithelium layer immunoreaction abnormity and mucosa injury after protect Reconstruction of The Function imbalance to have close relationship.Quantity research shows greatly, and OU morbidity is relevant to following factors: heredity, immune disorder, wound, virus or antibacterial infection, autoimmune, gastroenteropathy, anemia, endocrine disturbance, malnutrition and psychentonia etc.The sickness rate of OU is very high, and the sickness rate of population can be up to more than 25%.Wherein common with recurrent oral ulceration, while sending out at that time, more, repeatedly to show effect, the course of disease is generally 7-10 days, has comparatively violent causalgia between stage of attack, has brought great impact to patient's work, studying and living, has a strong impact on patient's quality of life.
The method of clinical treatment oral ulcer roughly can be divided into " external treatment " and " internal treatment " at present." external treatment " carries out antiinflammatory, pain relieving, anticorrosion and promote the treatment of healing mainly for ulcer wound surface; " internal treatment " usually carries out for immune system and Metabolic disorder, and conventional vitamin for oral administration, antimicrobial drug, hormone medicine or Chinese medicine ingredients are treated.But " external treatment ", although can directly act on surface, affected part, instant effect, and can alleviate the misery that disease is brought, its sometimes but index do not effect a permanent cure, therefore usually have recurrence, to patient, bring misery repeatedly; " internal treatment " focus on to regulate patient's self interest-free function, although recurrence that can oral ulcer but takes effect slow, and cannot alleviate the pain that disease is brought." external treatment " at present the normal pharmaceutical dosage form adopting mainly contains gargarism, paster etc., and they can make medicine directly act on affected part; The medicine of " internal treatment " is usually common various peroral dosage forms.
Biology cellulose (Biocellulose) refers to the cellulosic general name of the part bacterial strain metabolism growth in acetic acid Pseudomonas.It is widely used at field of food as outstanding dietary fiber source at present, and its trade name is " Cortex cocois radicis gel ".In addition, because it has superfine space network structure, be therefore also progressively used to the fields such as medical dressing.
Summary of the invention
For the problems referred to above, the invention provides a kind of paster of sucking for the treatment of of the inside combined with the outside treatment oral ulcer.
Treatment of the inside combined with the outside in the present invention treatment oral ulcer suck paster, it comprises its sugarcoating layer of biology cellulose layer and parcel, includes medicine or the active component of " can external treatment " oral ulcer for the treatment of effective dose in wherein said biology cellulose layer; And in described sugarcoating layer, include medicine or the active component of " can treatment by oral administration of medicines " oral ulcer for the treatment of effective dose.
Treatment of the inside combined with the outside described in the present invention treatment oral ulcer suck paster, medicine or the active component of wherein said " can external treatment " oral ulcer are: can carry out antiinflammatory, pain relieving, anticorrosion and promote medicine or the active component of healing to ulcer wound surface; Medicine or the active component of described " can treatment by oral administration of medicines " oral ulcer are: can antiinflammatory or can endocrine regulation, medicine or the active component of immune system and Metabolic disorder.
Medicine or the active component of above-mentioned " can external treatment " oral ulcer can be selected from but be not limited to: one or more in amoxicillin, hibitane, nitrofural, gentamycin sulfate, chlortetracycline.
Medicine or the active component of above-mentioned " can external treatment " oral ulcer are preferably: amoxicillin, hibitane and nitrofural, its preferred ratio is 1:1:2.
Medicine or the active component of above-mentioned " can treatment by oral administration of medicines " oral ulcer can be selected from but be not limited to: lysozyme, penicillin, levamisole, trace element, vitamin B group and Chinese medicine ingredients that can enhancing immunity.Described Chinese medicine ingredients is selected from but is not limited to the decocting liquid of following Chinese medicine: one or more in Radix Ginseng, the Radix Astragali, Ganoderma, Placenta Hominis, Cordyceps, Radix Schisandrae Bicoloris, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Fructus Hippophae, Herba Taraxaci, Radix Glycyrrhizae, Herba Houttuyniae, Cortex Phellodendri, Fructus Forsythiae, Rhizoma Phragmitis, Folium Mori, Pericarpium Citri Reticulatae, Fructus Jujubae, Herba Hedyotidis Diffusae, Rabdosia rubescens, Endothelium Corneum Gigeriae Galli, Galla Chinensis, the Folium Ligustri Lucidi, Borax and Mel.
Medicine or the active component of above-mentioned " can treatment by oral administration of medicines " oral ulcer are preferably: lysozyme, levamisole, trace element, vitamin B group and Chinese medicine ingredients that can enhancing immunity.
Described Chinese medicine ingredients that can enhancing immunity is preferably the decocting liquid of following Chinese medicine in the water of 100-120 weight portion: Radix Ginseng 1-2 weight portion, astragalus weight part 3-6, Fructus Lycii 1-2 weight portion, Radix Et Caulis Acanthopanacis Senticosi 5-10 weight portion, Fructus Hippophae 3-6 weight portion, Herba Taraxaci 5-10 weight portion, Radix Glycyrrhizae 5-10 weight portion, Herba Houttuyniae 3-6 weight portion, Cortex Phellodendri 3-6 weight portion, Folium Mori 5-10 weight portion, Herba Hedyotidis Diffusae 3-6 weight portion, Rabdosia rubescens 1-2 weight portion, Endothelium Corneum Gigeriae Galli 1-2 weight portion, Galla Chinensis 1-2 weight portion, Folium Ligustri Lucidi 1-2 weight portion, Borax 1-2 weight portion and Mel 3-5 weight portion.
The present invention also provides the preparation method of sucking paster of described treatment of the inside combined with the outside treatment oral ulcer, and it comprises the steps:
1) prepare biology cellulose film: preparation culture medium, after sterilizing, inoculate biology cellulose and produce bacterium, cultivate after 1-3 days for 28-32 ℃, solid-liquid separation biology cellulose film, more repeatedly clean purification with sig water and deionized water, make biology cellulose film;
2) make this biology cellulose film product section dehydration: adopt the mode of mechanical compress or cold drying to make the water content of biology cellulose film be reduced to 40-60 % by weight, make the biology cellulose film of partial dehydration;
3) preparation contains " can the external treatment " medicine of oral ulcer or medicinal liquid of active component: medicine or the active component of " can external treatment " oral ulcer for the treatment of effective dose are dissolved in distilled water, make " can the external treatment " medicine of oral ulcer or medicinal liquid of active component;
4) the biology cellulose film of partial dehydration is cut into after small pieces, in " can treatment by oral administration of medicines " medicine of oral ulcer or the medicinal liquid of active component, soak after 8-12 hour, after solid-liquid separation, cold drying is reduced to below 20 % by weight its water content;
5) preparation " can the treatment by oral administration of medicines " medicine of oral ulcer or the medicinal liquid of active component: medicine or the active component of " can treatment by oral administration of medicines " except Chinese medicine, that treat effective dose oral ulcer are dissolved in distilled water; And after raw material of Chinese medicine mixes according to described ratio, decoct with water 20-60min, and make decoction liquor, the two is mixed and made into medicine or the active component medicinal liquid of " can treatment by oral administration of medicines " oral ulcer;
6) medicine or the active component medicinal liquid of " can treatment by oral administration of medicines " oral ulcer are joined in liquid syrup, stir, then the biology cellulose sheet that makes to make in step 4) immerses in liquid syrup and hang syrup, drier at 40-50 ℃, make coating sclerosis.
In said method, step 2) in, preferably make biology cellulose partial dehydration to 45-50 % by weight.
In said method, the time that in step 5), raw material of Chinese medicine decocts with water is preferably 30-40min.
The paster for the treatment of canker sore provided by the present invention, outside sugar-coat can first dissolve in use, thereby ingredient or the active component of " can treatment by oral administration of medicines " oral ulcer are discharged, and makes patient for oral administration, plays the effect of interior treating dental ulcer; Along with dissolving of sugar-coat, biology cellulose film can expose, and is attached to ulcer place, just can slowly discharge ingredient or the active component of " can external treatment " oral ulcer, plays the effect of outer treating dental ulcer.The present invention can treat oral ulcer by treatment of the inside combined with the outside, and the external treatment of logical biology cellulose film can sterilize, sterilizes and promote wound healing ulcer wound; By the treatment by oral administration of medicines of sugar-coat, can endocrine regulation, improve immunity, avoid the recurrence repeatedly of oral ulcer.
The specific embodiment
Below in conjunction with embodiment, the specific embodiment of the present invention is described in further detail.Following examples are used for illustrating the present invention, but are not used for limiting the scope of the invention.
Embodiment 1: the preparation of the buccal tablet for the treatment of of the inside combined with the outside treatment oral ulcer
Preparation culture medium, inoculates biology cellulose and produces bacterium after sterilizing, cultivates after 1 day for 30 ℃, and solid-liquid separation biology cellulose film, more repeatedly clean purification with sig water and deionized water, make biology cellulose film, adopt the mode of mechanical compress to make the water content of biology cellulose film be reduced to 45 % by weight, make the biology cellulose film of partial dehydration, again by medicine or the active component of " can external treatment " oral ulcer for the treatment of effective dose: amoxicillin, hibitane and nitrofural are dissolved in distilled water with the ratio of 1:1:2, make " can the external treatment " medicine of oral ulcer or medicinal liquid of active component, the biology cellulose film of partial dehydration is cut into after small pieces again, in " can external treatment " medicine of oral ulcer or the medicinal liquid of active component, soak 8 hours, after solid-liquid separation, cold drying makes its water content be reduced to 12 weight, standby, again lysozyme, levamisole, trace element, the vitamin B group for the treatment of effective dose are dissolved in distilled water, by Radix Ginseng 1 weight portion, astragalus weight part 4 weight portions, Fructus Lycii 2 weight portions, Radix Et Caulis Acanthopanacis Senticosi 6 weight portions, Fructus Hippophae 3 weight portions, Herba Taraxaci 8 weight portions, Radix Glycyrrhizae 10 weight portions, Herba Houttuyniae 3 weight portions, Cortex Phellodendri 3 weight portions, Folium Mori 10 weight portions, Herba Hedyotidis Diffusae 3 weight portions, Rabdosia rubescens 1 weight portion, Endothelium Corneum Gigeriae Galli 2 weight portions, Galla Chinensis 1 weight portion, the Folium Ligustri Lucidi 1 weight portion, after Borax 1 weight portion and Mel 3 weight portions mix, add water 100 weight portions and decoct 30min, make decoction liquor, above-mentioned lysate and decoction liquor are mixed and made into medicine or the active component medicinal liquid of " can treatment by oral administration of medicines " oral ulcer, then medicine or the active component medicinal liquid of " can treatment by oral administration of medicines " oral ulcer are joined in liquid syrup, stir, again by above-mentioned standby absorption the cold drying biology cellulose sheet of " can external treatment " medicine of oral ulcer or the medicinal liquid of active component immerse in liquid syrup and hang syrup, dry at 40 ℃ again, make coating sclerosis.
Embodiment 2: the preparation of the buccal tablet for the treatment of of the inside combined with the outside treatment oral ulcer
Preparation culture medium, inoculates biology cellulose and produces bacterium after sterilizing, cultivates after 2 days for 28 ℃, and solid-liquid separation biology cellulose film, more repeatedly clean purification with sig water and deionized water, make biology cellulose film, adopt the mode of cold drying to make the water content of biology cellulose film be reduced to 50 % by weight, make the biology cellulose film of partial dehydration, again by medicine or the active component of " can external treatment " oral ulcer for the treatment of effective dose: amoxicillin, hibitane and nitrofural are dissolved in distilled water with the ratio of 1:1:2, make " can the external treatment " medicine of oral ulcer or medicinal liquid of active component, the biology cellulose film of partial dehydration is cut into after small pieces again, in " can external treatment " medicine of oral ulcer or the medicinal liquid of active component, soak 12 hours, after solid-liquid separation, cold drying makes its water content be reduced to 15 % by weight, standby, again lysozyme, levamisole, trace element, the vitamin B group for the treatment of effective dose are dissolved in distilled water, by Radix Ginseng 2 weight portions, astragalus weight part 5 weight portions, Fructus Lycii 1 weight portion, Radix Et Caulis Acanthopanacis Senticosi 3 weight portions, Fructus Hippophae 3 weight portions, Herba Taraxaci 5 weight portions, Radix Glycyrrhizae 5 weight portions, Herba Houttuyniae 6 weight portions, Cortex Phellodendri 6 weight portions, Folium Mori 10 weight portions, Herba Hedyotidis Diffusae 4 weight portions, Rabdosia rubescens 2 weight portions, Endothelium Corneum Gigeriae Galli 1 weight portion, Galla Chinensis 1 weight portion, the Folium Ligustri Lucidi 2 weight portions, after Borax 2 weight portions and Mel 5 weight portions mix, add water 100 weight portions and decoct 45min, make decoction liquor, above-mentioned lysate and decoction liquor are mixed and made into medicine or the active component medicinal liquid of " can treatment by oral administration of medicines " oral ulcer, then medicine or the active component medicinal liquid of " can treatment by oral administration of medicines " oral ulcer are joined in liquid syrup, stir, again by above-mentioned standby absorption the cold drying biology cellulose sheet of " can external treatment " medicine of oral ulcer or the medicinal liquid of active component immerse in liquid syrup and hang syrup, dry at 50 ℃ again, make coating sclerosis.
Experimental example 1: the therapeutic effect of the paster for the treatment of of the inside combined with the outside treatment oral ulcer
Choose at random 20 oral ulcer patients as experimental subject, using the buccal tablet that makes in above-described embodiment 1-2 as experimental example 1-2, with common commercially available mouth ulcer paster and the routine 1(external treatment contrast in contrast respectively of common commercially available mouth ulcer lozenge) and reference examples 2(treatment by oral administration of medicines contrast).By 20 every 5 people's one components of experimental subject, it is 4 groups at random, use respectively paster or the buccal tablet of experimental example 1-2 and reference examples 1-2, observe each experimental subject oral ulcer wound situation every day, continue 30 days, the time (averaging) of record recovery from illness, even if recovery from illness still keeps observing, record every group of number that occurs recurrence.The results are shown in following table:
| ? | Experimental example 1 | Experimental example 2 | Reference examples 1 | Reference examples 2 |
| Cure time (my god) | 3.4 | 3.6 | 4.2 | 6.6 |
| Recurrence number | 0 | 1 | 3 | 2 |
Visible, compared with the control, the paster of the treatment of the inside combined with the outside treatment oral ulcer that embodiment of the present invention 1-2 makes can accelerate the speed of oral ulcer recovery from illness, and prevents recurrence.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, do not departing under the prerequisite of the technology of the present invention principle; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (1)
1. treatment of the inside combined with the outside treatment oral ulcer sucks paster, be characterised in that: it comprises biology cellulose layer and its sugarcoating layer of parcel, in wherein said biology cellulose layer, include medicine or the active component of " can external treatment " oral ulcer for the treatment of effective dose; And in described sugarcoating layer, include medicine or the active component of " can treatment by oral administration of medicines " oral ulcer for the treatment of effective dose; Medicine or the active component of wherein said " can external treatment " oral ulcer are: can carry out antiinflammatory, pain relieving, anticorrosion and promote medicine or the active component of healing to ulcer wound surface; Medicine or the active component of described " can treatment by oral administration of medicines " oral ulcer are: can antiinflammatory or can endocrine regulation, medicine or the active component of immune system and Metabolic disorder.
Treatment of the inside combined with the outside according to claim 1 treatment oral ulcer suck paster, be characterised in that: medicine or the active component of above-mentioned " can external treatment " oral ulcer are selected from: one or more in amoxicillin, hibitane, nitrofural, gentamycin sulfate, chlortetracycline.
Treatment of the inside combined with the outside according to claim 2 treatment oral ulcer suck paster, be characterised in that: medicine or the active component of above-mentioned " can external treatment " oral ulcer are: amoxicillin, hibitane and nitrofural, its part by weight is 1:1:2.
Treatment of the inside combined with the outside according to claim 1 treatment oral ulcer suck paster, be characterised in that: medicine or the active component of above-mentioned " can treatment by oral administration of medicines " oral ulcer are selected from: lysozyme, penicillin, levamisole, trace element, vitamin B group and Chinese medicine ingredients that can enhancing immunity; Wherein said Chinese medicine ingredients that can enhancing immunity is the decocting liquid that is selected from following Chinese medicine: one or more in Radix Ginseng, the Radix Astragali, Ganoderma, Placenta Hominis, Cordyceps, Radix Schisandrae Bicoloris, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Fructus Hippophae, Herba Taraxaci, Radix Glycyrrhizae, Herba Houttuyniae, Cortex Phellodendri, Fructus Forsythiae, Rhizoma Phragmitis, Folium Mori, Pericarpium Citri Reticulatae, Fructus Jujubae, Herba Hedyotidis Diffusae, Rabdosia rubescens, Endothelium Corneum Gigeriae Galli, Galla Chinensis, the Folium Ligustri Lucidi, Borax and Mel.
5. treatment of the inside combined with the outside according to claim 4 is treated the paster of sucking of oral ulcer, be characterised in that: medicine or the active component of above-mentioned " can treatment by oral administration of medicines " oral ulcer are: lysozyme, levamisole, trace element, vitamin B group and Chinese medicine ingredients that can enhancing immunity, wherein said Chinese medicine ingredients that can enhancing immunity is the decocting liquid of following Chinese medicine in the water of 100-120 weight portion: Radix Ginseng 1-2 weight portion, Radix Astragali 3-6 weight portion, Fructus Lycii 1-2 weight portion, Radix Et Caulis Acanthopanacis Senticosi 5-10 weight portion, Fructus Hippophae 3-6 weight portion, Herba Taraxaci 5-10 weight portion, Radix Glycyrrhizae 5-10 weight portion, Herba Houttuyniae 3-6 weight portion, Cortex Phellodendri 3-6 weight portion, Folium Mori 5-10 weight portion, Herba Hedyotidis Diffusae 3-6 weight portion, Rabdosia rubescens 1-2 weight portion, Endothelium Corneum Gigeriae Galli 1-2 weight portion, Galla Chinensis 1-2 weight portion, Folium Ligustri Lucidi 1-2 weight portion, Borax 1-2 weight portion and Mel 3-5 weight portion.
6. the described treatment of the inside combined with the outside of one of claim 1-5 is treated a preparation method of sucking paster for oral ulcer, is characterised in that: it comprises the steps:
1) prepare biology cellulose film: preparation culture medium, after sterilizing, inoculate biology cellulose and produce bacterium, cultivate after 1-3 days for 28-32 ℃, solid-liquid separation biology cellulose film, more repeatedly clean purification with sig water and deionized water, make biology cellulose film;
2) make this biology cellulose film product section dehydration: adopt the mode of mechanical compress or cold drying to make the water content of biology cellulose film be reduced to 40-60 % by weight, make the biology cellulose film of partial dehydration;
3) preparation contains " can the external treatment " medicine of oral ulcer or medicinal liquid of active component: medicine or the active component of " can external treatment " oral ulcer for the treatment of effective dose are dissolved in distilled water, make " can the external treatment " medicine of oral ulcer or medicinal liquid of active component;
4) the biology cellulose film of partial dehydration is cut into after small pieces, in " can external treatment " medicine of oral ulcer or the medicinal liquid of active component, soak 8-12 hour, after solid-liquid separation, cold drying is reduced to below 20 % by weight its water content;
5) preparation " can the treatment by oral administration of medicines " medicine of oral ulcer or the medicinal liquid of active component: medicine or the active component of " can treatment by oral administration of medicines " except Chinese medicine, that treat effective dose oral ulcer are dissolved in distilled water; And after raw material of Chinese medicine is mixed in proportion, decoct with water 20-60min, and make decoction liquor, the two is mixed and made into medicine or the active component medicinal liquid of " can treatment by oral administration of medicines " oral ulcer;
6) " can treatment by oral administration of medicines " medicine of oral ulcer or the medicinal liquid of active component are joined in liquid syrup, stir, then the biology cellulose sheet that makes to make in step 4) immerses in liquid syrup and hang up syrup, drylier at 40-50 ℃ make coating sclerosis;
Medicine or the active component of wherein said " can external treatment " oral ulcer are: can carry out antiinflammatory, pain relieving, anticorrosion and promote medicine or the active component of healing to ulcer wound surface; Medicine or the active component of described " can treatment by oral administration of medicines " oral ulcer are: can antiinflammatory or can endocrine regulation, medicine or the active component of immune system and Metabolic disorder.
7. the preparation method of sucking paster for the treatment of of the inside combined with the outside according to claim 6 treatment oral ulcer, is characterised in that: in said method, step 2) in make biology cellulose partial dehydration to 45-50 % by weight.
8. according to the preparation method of sucking paster of the treatment of the inside combined with the outside treatment oral ulcer described in claim 6 or 7, be characterised in that: in said method, the time that in step 5), raw material of Chinese medicine decocts with water is 30-40min.
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| CN201310149700.2A CN103191418B (en) | 2013-04-26 | 2013-04-26 | Buccal patch for treating dental ulcer by combination of internal and external treatments |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104958230A (en) * | 2015-06-17 | 2015-10-07 | 天津市聚星康华医药科技有限公司 | Functional oral care composition and application thereof |
| CN106420835A (en) * | 2016-12-23 | 2017-02-22 | 郑州莉迪亚医药科技有限公司 | Pharmaceutical composition for curing dental ulcer and preparation method thereof |
| CN106474159A (en) * | 2016-12-23 | 2017-03-08 | 郑州莉迪亚医药科技有限公司 | A kind of treat medicine of oral ulcer and preparation method thereof |
| CN108785496A (en) * | 2018-09-03 | 2018-11-13 | 解智强 | A kind of canker sore sustained release pad pasting and preparation method thereof |
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