CN103191418A - Buccal patch for treating dental ulcer by combination of internal and external treatments - Google Patents
Buccal patch for treating dental ulcer by combination of internal and external treatments Download PDFInfo
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- CN103191418A CN103191418A CN2013101497002A CN201310149700A CN103191418A CN 103191418 A CN103191418 A CN 103191418A CN 2013101497002 A CN2013101497002 A CN 2013101497002A CN 201310149700 A CN201310149700 A CN 201310149700A CN 103191418 A CN103191418 A CN 103191418A
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Abstract
The invention relates to a buccal patch for treating dental ulcer by combination of internal and external treatments. The patch comprises a biological cellulose layer and a sugar-coating layer which coats the biological cellulose, wherein the biological cellulose layer comprises medicinal components or active components capable of externally treating dental ulcer; and the sugar-coating layer comprises medicines or active components capable of internally treating dental ulcer. When the patch is used, the external sugar coating is dissolved firstly to release the medicines or active components capable of internally treating the dental ulcer, so that an internal treatment effect is played when a patient takes the patch; and along with dissolution of the sugar coating, the biological cellulose film is exposed, and the patch is applied to the ulcer position to slowly release the medicines or active components capable of externally treating dental ulcer to play the effect of external treatment. The buccal patch can be used for treating dental ulcer by combination of internal and external treatments, which means that the ulcer wound can be sterilized and disinfected and the wound healing can be accelerated; and the buccal patch can be used for regulating endocrine and improving the immunity, so that the repeated relapse of dental ulcer can be avoided.
Description
Technical field
The present invention relates to a kind of paster of sucking, particularly relate to a kind of paster of sucking of interior external treatment combined treatment oral ulcer.
Background technology
(oral ulcer OU), is called " aphtha " again to oral ulcer, is a kind of common oral mucosa disease, is that the integrity generation persistence of oral mucosa epithelium is damaged or destroy, the superficial necrosis depression that forms that comes off.The cause of disease is comparatively complicated, and may rebuild functional disorder with protection behind mucosal epithelium layer immunoreaction abnormity and the mucosa injury has close relationship.Studies show that in a large number the OU morbidity is relevant with following factors: heredity, immune disorder, wound, virus or bacterial infection, autoimmune, gastroenteropathy, anemia, endocrine disturbance, malnutrition and psychentonia etc.The sickness rate of OU is very high, and general crowd's sickness rate can be up to more than 25%.Wherein common with recurrent oral ulceration, more, to show effect repeatedly when sending out at that time, the course of disease was generally 7-10 days, and comparatively violent causalgia was arranged between stage of attack, had brought great influence for patient's work, studying and living, had a strong impact on patient's quality of life.
The method of clinical treatment oral ulcer roughly can be divided into " external treatment " and " internal treatment " at present." external treatment " is primarily aimed at ulcer wound surface and carries out antiinflammatory, pain relieving, anticorrosion and promote the treatment of healing; " internal treatment " then usually carries out at immune system and Metabolic disorder, and vitamin for oral administration commonly used, antimicrobial drug, hormone medicine or Chinese medicine ingredients are treated.But " external treatment " instant effect, and can alleviate the misery that disease is brought though can directly act on the surface, affected part, its sometimes but index do not effect a permanent cure, therefore usually have recurrence, bring repeatedly misery to the patient; " internal treatment " pay attention to regulate patient's self interest-free function, though recurrence that can oral ulcer, it is slow but to take effect, and can't alleviate the pain that disease is brought." external treatment " the normal pharmaceutical dosage form that adopts at present mainly contains gargarism, paster etc., and they can make medicine directly act on the affected part; The medicine of " internal treatment " then usually is common various peroral dosage forms.
Biology cellulose (Biocellulose) refers to the cellulosic general name by the part bacterial strain metabolism growth in the acetic acid Pseudomonas.It is widely used at field of food as outstanding dietary fiber source at present, and its trade name is " Cortex cocois radicis gel ".In addition, because it has superfine space network structure, therefore also progressively be used to fields such as medical dressing.
Summary of the invention
At the problems referred to above, the invention provides a kind of paster of sucking of interior external treatment combined treatment oral ulcer.
Interior external treatment combined treatment oral ulcer among the present invention suck paster, it comprises its sugarcoating layer of biology cellulose layer and parcel, includes medicine or the active component of " but external treatment " oral ulcer for the treatment of effective dose in the wherein said biology cellulose layer; And include medicine or the active component of " but treatment by oral administration of medicines " oral ulcer for the treatment of effective dose in the described sugarcoating layer.
Interior external treatment combined treatment oral ulcer described in the present invention suck paster, medicine or the active component of wherein said " but external treatment " oral ulcer are: can carry out antiinflammatory, pain relieving, anticorrosion and promote medicine or the active component of healing to ulcer wound surface; Medicine or the active component of described " but treatment by oral administration of medicines " oral ulcer are: can antiinflammatory or can endocrine regulation, medicine or the active component of immune system and Metabolic disorder.
The medicine of above-mentioned " but external treatment " oral ulcer or active component can be selected from but be not limited to: one or more in amoxicillin, hibitane, nitrofural, gentamycin sulfate, the chlortetracycline.
Medicine or the active component of above-mentioned " but external treatment " oral ulcer are preferably: amoxicillin, hibitane and nitrofural, its preferred ratio is 1:1:2.
The medicine of above-mentioned " but treatment by oral administration of medicines " oral ulcer or active component can be selected from but be not limited to: but the Chinese medicine ingredients of lysozyme, penicillin, levamisole, trace element, vitamin B group and enhancing immunity.Described Chinese medicine ingredients is selected from but is not limited to the decocting liquid of following Chinese medicine: one or more in Radix Ginseng, the Radix Astragali, Ganoderma, Placenta Hominis, Cordyceps, Radix Schisandrae Bicoloris, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Fructus Hippophae, Herba Taraxaci, Radix Glycyrrhizae, Herba Houttuyniae, Cortex Phellodendri, Fructus Forsythiae, Rhizoma Phragmitis, Folium Mori, Pericarpium Citri Reticulatae, Fructus Jujubae, Herba Hedyotidis Diffusae, Rabdosia rubescens, Endothelium Corneum Gigeriae Galli, Galla Chinensis, the Folium Ligustri Lucidi, Borax and the Mel.
Medicine or the active component of above-mentioned " but treatment by oral administration of medicines " oral ulcer are preferably: but the Chinese medicine ingredients of lysozyme, levamisole, trace element, vitamin B group and enhancing immunity.
But the Chinese medicine ingredients of described enhancing immunity is preferably the decocting liquid of following Chinese medicine in the water of 100-120 weight portion: Radix Ginseng 1-2 weight portion, astragalus weight part 3-6, Fructus Lycii 1-2 weight portion, Radix Et Caulis Acanthopanacis Senticosi 5-10 weight portion, Fructus Hippophae 3-6 weight portion, Herba Taraxaci 5-10 weight portion, Radix Glycyrrhizae 5-10 weight portion, Herba Houttuyniae 3-6 weight portion, Cortex Phellodendri 3-6 weight portion, Folium Mori 5-10 weight portion, Herba Hedyotidis Diffusae 3-6 weight portion, Rabdosia rubescens 1-2 weight portion, Endothelium Corneum Gigeriae Galli 1-2 weight portion, Galla Chinensis 1-2 weight portion, Folium Ligustri Lucidi 1-2 weight portion, Borax 1-2 weight portion and Mel 3-5 weight portion.
The present invention also provides the preparation method of sucking paster of described interior external treatment combined treatment oral ulcer, and it comprises the steps:
1) preparation biology cellulose film: the preparation culture medium, inoculation biology cellulose in sterilization back produces bacterium, cultivates after 1-3 days for 28-32 ℃, and solid-liquid separation goes out the biology cellulose film, cleans purification repeatedly with sig water and deionized water again, makes the biology cellulose film;
2) make this biology cellulose film product section dehydration: adopt the mode of mechanical compress or cold drying to make the water content of biology cellulose film be reduced to 40-60 weight %, make the biology cellulose film of partial dehydration;
3) preparation contains the medicine of " but external treatment " oral ulcer or the medicinal liquid of active component: medicine or the active component that will treat " but external treatment " oral ulcer of effective dose are dissolved in the distilled water, make the medicine of " but external treatment " oral ulcer or the medicinal liquid of active component;
4) the biology cellulose film of partial dehydration is cut into small pieces after, in the medicinal liquid of the medicine of " but treatment by oral administration of medicines " oral ulcer or active component, soak 8-12 hour after, after the solid-liquid separation, cold drying is reduced to below the 20 weight % its water content;
5) medicine of preparation " but treatment by oral administration of medicines " oral ulcer or the medicinal liquid of active component: medicine or active component except Chinese medicine, that treat " but treatment by oral administration of medicines " oral ulcer of effective dose are dissolved in the distilled water; And after raw material of Chinese medicine mixes according to described ratio, decoct with water 20-60min, and make decoction liquor, the two is mixed and made into medicine or the active component medicinal liquid of " but treatment by oral administration of medicines " oral ulcer;
6) medicine or the active component medicinal liquid with " but treatment by oral administration of medicines " oral ulcer joins in the liquid syrup, stirs, and the biology cellulose sheet that makes in the step 4) immersed in the liquid syrup hang syrup, and be dry under 40-50 ℃ again, and the coating sclerosis is got final product.
In the said method, step 2) preferably make the biology cellulose partial dehydration to 45-50 weight % in.
In the said method, the time that raw material of Chinese medicine decocts with water in the step 5) is preferably 30-40min.
The paster for the treatment of canker sore provided by the present invention, Wai Bu sugar-coat can dissolve earlier in use, thereby ingredient or the active component of " but treatment by oral administration of medicines " oral ulcer are discharged, and makes the patient for oral administration, the effect for the treatment of dental ulcer in playing; Along with dissolving of sugar-coat, the biology cellulose film can expose, and it is attached to the ulcer place, just can slowly discharge ingredient or the active component of " but external treatment " oral ulcer, plays the effect of outer treating dental ulcer.The present invention can in external treatment combined treatment oral ulcer, the external treatment of logical biology cellulose film can and promote wound healing to the sterilization of ulcer wound, sterilization; By the treatment by oral administration of medicines of sugar-coat, can endocrine regulation, improve immunity, avoid the recurrence repeatedly of oral ulcer.
The specific embodiment
Below in conjunction with embodiment, the specific embodiment of the present invention is described in further detail.Following examples are used for explanation the present invention, but are not used for limiting the scope of the invention.
Embodiment 1: the preparation of the buccal tablet of interior external treatment combined treatment oral ulcer
The preparation culture medium, inoculation biology cellulose in sterilization back produces bacterium, cultivates after 1 day for 30 ℃, and solid-liquid separation goes out the biology cellulose film, cleans purification repeatedly with sig water and deionized water again, makes the biology cellulose film; Adopt the mode of mechanical compress to make the water content of biology cellulose film be reduced to 45 weight %, make the biology cellulose film of partial dehydration; To treat medicine or the active component of " but external treatment " oral ulcer of effective dose again: amoxicillin, hibitane and nitrofural are dissolved in the distilled water with the ratio of 1:1:2, make the medicine of " but external treatment " oral ulcer or the medicinal liquid of active component; After again the biology cellulose film of partial dehydration being cut into small pieces, soaked 8 hours in the medicinal liquid of the medicine of " but external treatment " oral ulcer or active component, after the solid-liquid separation, cold drying makes its water content be reduced to 12 weight, and is standby; Lysozyme, levamisole, trace element, the vitamin B group that to treat effective dose again are dissolved in the distilled water; With Radix Ginseng 1 weight portion, astragalus weight part 4 weight portions, Fructus Lycii 2 weight portions, Radix Et Caulis Acanthopanacis Senticosi 6 weight portions, Fructus Hippophae 3 weight portions, Herba Taraxaci 8 weight portions, Radix Glycyrrhizae 10 weight portions, Herba Houttuyniae 3 weight portions, Cortex Phellodendri 3 weight portions, Folium Mori 10 weight portions, Herba Hedyotidis Diffusae 3 weight portions, Rabdosia rubescens 1 weight portion, Endothelium Corneum Gigeriae Galli 2 weight portions, Galla Chinensis 1 weight portion, the Folium Ligustri Lucidi 1 weight portion, after Borax 1 weight portion and Mel 3 weight portions mix, add water 100 weight portions and decoct 30min, make decoction liquor, above-mentioned lysate and decoction liquor are mixed and made into medicine or the active component medicinal liquid of " but treatment by oral administration of medicines " oral ulcer; Medicine or active component medicinal liquid with " but treatment by oral administration of medicines " oral ulcer joins in the liquid syrup then, stir, again with above-mentioned standby absorption the cold drying biology cellulose sheet of medicinal liquid of the medicine of " but external treatment " oral ulcer or active component immerse in the liquid syrup and hang syrup, dry under 40 ℃ again, the coating sclerosis is got final product.
Embodiment 2: the preparation of the buccal tablet of interior external treatment combined treatment oral ulcer
The preparation culture medium, inoculation biology cellulose in sterilization back produces bacterium, cultivates after 2 days for 28 ℃, and solid-liquid separation goes out the biology cellulose film, cleans purification repeatedly with sig water and deionized water again, makes the biology cellulose film; Adopt the mode of cold drying to make the water content of biology cellulose film be reduced to 50 weight %, make the biology cellulose film of partial dehydration; To treat medicine or the active component of " but external treatment " oral ulcer of effective dose again: amoxicillin, hibitane and nitrofural are dissolved in the distilled water with the ratio of 1:1:2, make the medicine of " but external treatment " oral ulcer or the medicinal liquid of active component; After again the biology cellulose film of partial dehydration being cut into small pieces, soaked 12 hours in the medicinal liquid of the medicine of " but external treatment " oral ulcer or active component, after the solid-liquid separation, cold drying makes its water content be reduced to 15 weight %, and is standby; Lysozyme, levamisole, trace element, the vitamin B group that to treat effective dose again are dissolved in the distilled water; With Radix Ginseng 2 weight portions, astragalus weight part 5 weight portions, Fructus Lycii 1 weight portion, Radix Et Caulis Acanthopanacis Senticosi 3 weight portions, Fructus Hippophae 3 weight portions, Herba Taraxaci 5 weight portions, Radix Glycyrrhizae 5 weight portions, Herba Houttuyniae 6 weight portions, Cortex Phellodendri 6 weight portions, Folium Mori 10 weight portions, Herba Hedyotidis Diffusae 4 weight portions, Rabdosia rubescens 2 weight portions, Endothelium Corneum Gigeriae Galli 1 weight portion, Galla Chinensis 1 weight portion, the Folium Ligustri Lucidi 2 weight portions, after Borax 2 weight portions and Mel 5 weight portions mix, add water 100 weight portions and decoct 45min, make decoction liquor, above-mentioned lysate and decoction liquor are mixed and made into medicine or the active component medicinal liquid of " but treatment by oral administration of medicines " oral ulcer; Medicine or active component medicinal liquid with " but treatment by oral administration of medicines " oral ulcer joins in the liquid syrup then, stir, again with above-mentioned standby absorption the cold drying biology cellulose sheet of medicinal liquid of the medicine of " but external treatment " oral ulcer or active component immerse in the liquid syrup and hang syrup, dry under 50 ℃ again, the coating sclerosis is got final product.
Experimental example 1: the therapeutic effect of the paster of interior external treatment combined treatment oral ulcer
20 oral ulcer patients of picked at random are as experimental subject, with the buccal tablet that makes among above-described embodiment 1-2 as experimental example 1-2, with common commercially available mouth ulcer paster and the routine 1(external treatment contrast in contrast respectively of common commercially available mouth ulcer lozenge) and reference examples 2(treatment by oral administration of medicines contrast).It is 4 groups with 20 per 5 people of experimental subject one components at random, use paster or the buccal tablet of experimental example 1-2 and reference examples 1-2 respectively, observe each experimental subject oral ulcer wound situation every day, continue 30 days, the time (averaging) of record recovery from illness, even recovery from illness still keeps observing, record every group of number that recurrence occurs.The results are shown in following table:
| ? | Experimental example 1 | Experimental example 2 | Reference examples 1 | Reference examples 2 |
| Cure time (my god) | 3.4 | 3.6 | 4.2 | 6.6 |
| The recurrence number | 0 | 1 | 3 | 2 |
As seen, compared with the control, the paster of the interior external treatment combined treatment oral ulcer that embodiment of the invention 1-2 makes can accelerate the speed of oral ulcer recovery from illness, and prevents recurrence.
The above only is preferred implementation of the present invention; should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the technology of the present invention principle; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (9)
- In one kind external treatment combined treatment oral ulcer suck paster, be characterised in that: it comprises biology cellulose layer and the sugarcoating layer that wraps up it, includes medicine or the active component of " but external treatment " oral ulcer for the treatment of effective dose in the wherein said biology cellulose layer; And include medicine or the active component of " but treatment by oral administration of medicines " oral ulcer for the treatment of effective dose in the described sugarcoating layer.
- 2. in according to claim 1 external treatment combined treatment oral ulcer suck paster, be characterised in that: medicine or the active component of wherein said " but external treatment " oral ulcer are: can carry out antiinflammatory, pain relieving, anticorrosion and promote medicine or the active component of healing to ulcer wound surface; Medicine or the active component of described " but treatment by oral administration of medicines " oral ulcer are: can antiinflammatory or can endocrine regulation, medicine or the active component of immune system and Metabolic disorder.
- 3. in according to claim 2 external treatment combined treatment oral ulcer suck paster, be characterised in that: medicine or the active component of above-mentioned " but external treatment " oral ulcer are selected from: one or more in amoxicillin, hibitane, nitrofural, gentamycin sulfate, the chlortetracycline.
- 4. in according to claim 3 external treatment combined treatment oral ulcer suck paster, be characterised in that: medicine or the active component of above-mentioned " but external treatment " oral ulcer are: amoxicillin, hibitane and nitrofural, its part by weight are 1:1:2.
- 5. in according to claim 2 external treatment combined treatment oral ulcer suck paster, be characterised in that: medicine or the active component of above-mentioned " but treatment by oral administration of medicines " oral ulcer are selected from: but the Chinese medicine ingredients of lysozyme, penicillin, levamisole, trace element, vitamin B group and enhancing immunity; But the Chinese medicine ingredients of wherein said enhancing immunity is the decocting liquid that is selected from following Chinese medicine: one or more in Radix Ginseng, the Radix Astragali, Ganoderma, Placenta Hominis, Cordyceps, Radix Schisandrae Bicoloris, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Fructus Hippophae, Herba Taraxaci, Radix Glycyrrhizae, Herba Houttuyniae, Cortex Phellodendri, Fructus Forsythiae, Rhizoma Phragmitis, Folium Mori, Pericarpium Citri Reticulatae, Fructus Jujubae, Herba Hedyotidis Diffusae, Rabdosia rubescens, Endothelium Corneum Gigeriae Galli, Galla Chinensis, the Folium Ligustri Lucidi, Borax and the Mel.
- 6. external treatment combined treatment oral ulcer sucks paster in according to claim 5, be characterised in that: medicine or the active component of above-mentioned " but treatment by oral administration of medicines " oral ulcer are: lysozyme, levamisole, trace element, but the Chinese medicine ingredients of vitamin B group and enhancing immunity, but the Chinese medicine ingredients of wherein said enhancing immunity is the decocting liquid of following Chinese medicine in the water of 100-120 weight portion: Radix Ginseng 1-2 weight portion, astragalus weight part 3-6, Fructus Lycii 1-2 weight portion, Radix Et Caulis Acanthopanacis Senticosi 5-10 weight portion, Fructus Hippophae 3-6 weight portion, Herba Taraxaci 5-10 weight portion, Radix Glycyrrhizae 5-10 weight portion, Herba Houttuyniae 3-6 weight portion, Cortex Phellodendri 3-6 weight portion, Folium Mori 5-10 weight portion, Herba Hedyotidis Diffusae 3-6 weight portion, Rabdosia rubescens 1-2 weight portion, Endothelium Corneum Gigeriae Galli 1-2 weight portion, Galla Chinensis 1-2 weight portion, Folium Ligustri Lucidi 1-2 weight portion, Borax 1-2 weight portion and Mel 3-5 weight portion.
- One of claim 1-6 described in the preparation method of sucking paster of external treatment combined treatment oral ulcer, be characterised in that: it comprises the steps:1) preparation biology cellulose film: the preparation culture medium, inoculation biology cellulose in sterilization back produces bacterium, cultivates after 1-3 days for 28-32 ℃, and solid-liquid separation goes out the biology cellulose film, cleans purification repeatedly with sig water and deionized water again, makes the biology cellulose film;2) make this biology cellulose film product section dehydration: adopt the mode of mechanical compress or cold drying to make the water content of biology cellulose film be reduced to 40-60 weight %, make the biology cellulose film of partial dehydration;3) preparation contains the medicine of " but external treatment " oral ulcer or the medicinal liquid of active component: medicine or the active component that will treat " but external treatment " oral ulcer of effective dose are dissolved in the distilled water, make the medicine of " but external treatment " oral ulcer or the medicinal liquid of active component;4) the biology cellulose film of partial dehydration is cut into small pieces after, in the medicinal liquid of the medicine of " but treatment by oral administration of medicines " oral ulcer or active component, soaked 8-12 hour, after the solid-liquid separation, cold drying is reduced to below the 20 weight % its water content;5) medicine of preparation " but treatment by oral administration of medicines " oral ulcer or the medicinal liquid of active component: medicine or active component except Chinese medicine, that treat " but treatment by oral administration of medicines " oral ulcer of effective dose are dissolved in the distilled water; And after raw material of Chinese medicine is mixed in proportion, decoct with water 20-60min, and make decoction liquor, the two is mixed and made into medicine or the active component medicinal liquid of " but treatment by oral administration of medicines " oral ulcer;6) medicine of " but treatment by oral administration of medicines " oral ulcer or the medicinal liquid of active component are joined in the liquid syrup, stir, the biology cellulose sheet that makes in the step 4) is immersed in the liquid syrup hang up syrup, 40-50 ℃ of following drying the coating sclerosis is got final product again.
- 8. the preparation method of sucking paster of external treatment combined treatment oral ulcer in according to claim 7 is characterised in that: in the said method, step 2) in make the biology cellulose partial dehydration to 45-50 weight %.
- 9. according to the preparation method of sucking paster of claim 7 or 8 described interior external treatment combined treatment oral ulcer, be characterised in that: in the said method, the time that raw material of Chinese medicine decocts with water in the step 5) is 30-40min.
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Cited By (4)
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| CN104958230A (en) * | 2015-06-17 | 2015-10-07 | 天津市聚星康华医药科技有限公司 | Functional oral care composition and application thereof |
| CN106420835A (en) * | 2016-12-23 | 2017-02-22 | 郑州莉迪亚医药科技有限公司 | Pharmaceutical composition for curing dental ulcer and preparation method thereof |
| CN106474159A (en) * | 2016-12-23 | 2017-03-08 | 郑州莉迪亚医药科技有限公司 | A kind of treat medicine of oral ulcer and preparation method thereof |
| CN108785496A (en) * | 2018-09-03 | 2018-11-13 | 解智强 | A kind of canker sore sustained release pad pasting and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104958230A (en) * | 2015-06-17 | 2015-10-07 | 天津市聚星康华医药科技有限公司 | Functional oral care composition and application thereof |
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| CN106474159A (en) * | 2016-12-23 | 2017-03-08 | 郑州莉迪亚医药科技有限公司 | A kind of treat medicine of oral ulcer and preparation method thereof |
| CN108785496A (en) * | 2018-09-03 | 2018-11-13 | 解智强 | A kind of canker sore sustained release pad pasting and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN103191418B (en) | 2014-07-16 |
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