CN101461832A - Bioadhesive paster for treating mouth ulcer - Google Patents
Bioadhesive paster for treating mouth ulcer Download PDFInfo
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- CN101461832A CN101461832A CNA2007101156248A CN200710115624A CN101461832A CN 101461832 A CN101461832 A CN 101461832A CN A2007101156248 A CNA2007101156248 A CN A2007101156248A CN 200710115624 A CN200710115624 A CN 200710115624A CN 101461832 A CN101461832 A CN 101461832A
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Abstract
The invention aims to provide a specific medicine capable of treating canker sore disease. Xilei powder is traditional Chinese medicine oral powder with definite treatment effect, and has the functions of detoxifying and promoting granulation and releasing swelling analgesia, but the acting time of the medicine on a focus position is short because the medicine after application is quickly dissolved in saliva, so that the medicine effect can not be given full play. The invention adopts a biological adhesive, namely prepares the Xilei powder into a biological adhesive tablet, and coats ethyl cellulose on one surface of the tablet, so that the medicine not only has the adhesion function but also can be positioned and released, prolongs the acting time of the medicine on the focus position, and has the functions of positioning and slow release. The specific medicine has the advantages that: firstly, the specific medicine is suitable for treating various canker sores and recurrent canker sores; secondly, the specific medicine can quickly relieve pain, prolongs the acting time of the medicine on the focus position, is directionally released, quickens cure of canker, improves the treatment effect, and relieve pain of patients; thirdly, the specific medicine has no toxic and side effects, and treats both principal and secondary aspect of the disease; and fourthly, the specific medicine has simple and convenient operation and use method, and can be widely popularized and applied.
Description
Technical field the objective of the invention is for a kind of specific medicament that is used for the treatment of oral ulcer is provided, and (Recurrent Oral Ulceration ROU) is department of stomatology commonly encountered diseases, frequently-occurring disease for oral ulcer, recurrent oral ulceration.Particularly recurrent oral ulceration up to about 20%, accounts for the first place of diseases of oral mucosa according to the prevalence of statistics demonstration both at home and abroad, has caused the great attention of domestic and international oral expert.The primary disease age of onset is extensive, the child, the adult, can fall ill old age per capita, and characteristics of incidence is local causalgia, and ulcer is difficult to healing and outbreak repeatedly, though this type of disease is non-life-threatening, but patient eats, drink, even speak waiting daily life work all to be had a strong impact on, feed is difficult, causes suffering and stress to the patient, because this disease cause of disease is very intricate, so far still indeterminate, therefore clinical do not have a specific treatment method, and modern medicine does not have specific drugs clinically, it is conventional treatment, as: oral vitamin, antibiotics etc., curative effect is undesirable, and the patient suffering can't bear.Systemic drug treatment lacks specific aim, so topical therapeutic is main Therapeutic Method, and it is reliable therefore to seek a kind of curative effect, and dosage form advanced person's stomatocace medicine is vast oral ulcer disease patient's long-term expectation.
Background technology the object of the present invention is to provide a kind ofly can treat the reliable Chinese medicine preparation of oral ulcer curative effect of disease, XILEI SAN is a kind of oral cavity Chinese powder medicine of determined curative effect, effect with detoxifcation removing the necrotic tissue and promoting granulation, reducing swelling and alleviating pain is mainly used in oral ulcer, recurrent oral ulceration and throat erosion oral disease such as swell and ache clinically.But because its dosage form falls behind, again because the particularity in oral cavity, therefore medicine is dissolved in saliva very soon after the medication, medicine and lesions position action time, the short drug effect curative effect that is not in full use was undesirable, this soaks into relevant, also relevant with the limitation of medicine with the particularity-saliva of oral mucosa environment of living in.Therefore the present invention has adopted bioadhesive polymer, improves pharmaceutical dosage form, mainly is to prevent secondary infection, alleviates pain, promotes ulcer healing and shortens the course of treatment.
Summary of the invention main points of the present invention are to select suitable component, and rationally be mixed, through a series of system granules, the granulate oven dry, tabletting, oven dry, technologies such as packing, adopted bioadhesive polymer, improve pharmaceutical dosage form, this medicine adds low-substituted hydroxypropyl cellulose and sodium carboxymethyl cellulose with XILEI SAN, makes a kind of biological adhesive tablet, and is coated with the ethyl cellulose in the one side of tablet, make stannum class bioadhesive paster, make the existing adhesive attraction of medicine locate release again, medicine prolonged in lesions position action time after this had just played the medicine medication, effectively resisted saliva washing away, can give full play to curative effect, reach therapeutic purposes.
The prescription following (component and percentage by weight % thereof) that the present invention selects: XILEI SAN 30-35, magnesium stearate 0.3, binding agent (sodium carboxymethyl cellulose: low-substituted hydroxypropyl cellulose=1:1.1) add to 100
The main effect of Indigo Naturalis is a heat-clearing and toxic substances removing in the XILEI SAN component, the removing heat from blood detumescence, impel inflammation to alleviate, its main component is indigo and indirubin, pharmacological evaluation finds that indirubin can strengthen the huge phagocytic activity of biting system of monokaryon of animal, and bacteriostasis is arranged, thereby play the effect of clearing away heat and cooling blood convergence removing toxic substances and promoting subsidence of swelling.Dens Elephatis has heat clearing away; removing toxic substances and promoting granulation; the effect of reducing swelling and alleviating pain; Uroctea compatilis Koch. charcoal, Concha have the effect of removing pathogenic heat from blood and toxic substance from the body, and Calculus Bovis has the effect of clearing away heart-fire detoxification, and Margarita has the effect of removing toxic substances and promoting granulation; Borneolum Syntheticum has heat-clearing and toxic substances removing; the effect of reducing swelling and alleviating pain has certain bacteriostasis and anesthetic action, easily absorbs in mucosa and subcutaneous tissue.Pharmacological evaluation proves, be applied to local very light to sensorineural stimulation, and pain relieving and gentle antisepsis arranged, some ulcer or stomatocace there is better curative effect, analgesic effect is obvious, quickens inflammation and eliminates, and what promote oral mucosa strips off erosion and ulcer healing, particularly respond well to the caused mucosal injury of physical factor, and also can bring into play the auxiliary treatment effect to the mucosal injury due to antibacterial or other complicated factors.All medicines all have the merit of heat-clearing and toxic substances removing in the side, and all medicines share and play the heat-clearing and toxic substances removing corruption altogether, the merit of muscle-growing and detumescence pain relieving.
The preparation method of product of the present invention is:
1) the XILEI SAN prescription is formed (percentage by weight %): Dens Elephatis 21, Indigo Naturalis 42, Concha 3, Uroctea compatilis Koch. charcoal 7, Margarita 21, Borneolum Syntheticum 2, Calculus Bovis 3; More than seven the flavor, except that Calculus Bovis, Borneolum Syntheticum, Margarita is ground into impalpable powder; Four flavors such as all the other Dens Elephatiss are ground into fine powder, sieve; With powder facing-ups such as above-mentioned Calculus Boviss, sieve mixing standby (being XILEI SAN).
2) with low-substituted hydroxypropyl cellulose (L-HPC), sodium carboxymethyl cellulose (CMC-Na) in drying baker 100 ℃ dry 2 hours down, it is standby to cross 100 mesh sieves respectively.
3) by XILEI SAN 30-35, magnesium stearate 0.3, binding agent (sodium carboxymethyl cellulose: low-substituted hydroxypropyl cellulose=1:1.1) add to 100 to take by weighing supplementary material, mixing, the alcoholic solution system soft material with 50% is crossed 16-18 mesh sieves, the system granule, with particle drying, granulate.
4) will go up granule that method makes and add 0.3% magnesium stearate, mix homogeneously is pressed into diameter 10mm, and sheet heavily is the thin slice of 0.15g, and is coated with the ethyl cellulose in the one side of tablet, 80 ℃ of oven dry.
5) carry out packing after the cooling.Check, warehousing after passing.
The present invention has the following advantages: be suitable for the treatment of various oral ulcer and recurrent oral ulceration 1..2. special process preparation, stannum class bioadhesive paster treatment oral ulcer and recurrent oral ulceration have been avoided the limitation of simple Chinese powder medicine treatment, have solved saliva effectively and have washed away the difficult problem that medicine comes off.3. pain relieving rapidly, ulcer healing is accelerated in the action time and the directed release of medicine that have prolonged medicine and lesions position, has improved curative effect, has alleviated patient's misery.4. short treating period, instant effect has no side effect, treating both the principal and secondary aspects of a disease.5. it is easy to manipulate method, and it can be applied widely.
The present invention is described in further detail below in conjunction with embodiment for the specific embodiment:
Be configured according to following table institute column data (percentage by weight %) and described step thereof:
Prescription one:
XILEI SAN 30-35
Magnesium stearate 0.3
Binding agent (sodium carboxymethyl cellulose: low-substituted hydroxypropyl cellulose=1:1.1) add to 100
Prescription two:
XILEI SAN 30-35.5
Magnesium stearate 0.3
Binding agent (sodium carboxymethyl cellulose: low-substituted hydroxypropyl cellulose=1:1.1) add to 100
Prescription three:
XILEI SAN 30.5-35
Magnesium stearate 0.3
Binding agent (sodium carboxymethyl cellulose: low-substituted hydroxypropyl cellulose=1:1.1) add to 100
Prescription four:
XILEI SAN 29.5-35
Magnesium stearate 0.3
Binding agent (sodium carboxymethyl cellulose: low-substituted hydroxypropyl cellulose=1:1.1) add to 100
Claims (2)
1, a kind of bioadhesive paster for the treatment of oral ulcer, the prescription following (component and percentage by weight % thereof) that the present invention selects: XILEI SAN 30-35, magnesium stearate 0.3, binding agent (sodium carboxymethyl cellulose: low-substituted hydroxypropyl cellulose=1:1.1) add to 100.
2, the preparation method of the described product of the present invention of a kind of claim 1 is characterized in that having following step:
1) with low-substituted hydroxypropyl cellulose (L-HPC), sodium carboxymethyl cellulose (CMC-Na) in drying baker 100 ℃ dry 2 hours down, it is standby to cross 100 mesh sieves respectively;
2) by XILEI SAN 30-35, magnesium stearate 0.3, binding agent (sodium carboxymethyl cellulose: low-substituted hydroxypropyl cellulose=1:1.1) add to 100 to take by weighing supplementary material, mixing, the alcoholic solution system soft material with 50% is crossed 16-18 mesh sieves, the system granule, with particle drying, granulate;
3) will go up granule that method makes and add 0.3% magnesium stearate, mix homogeneously is pressed into diameter 10mm, and sheet heavily is the thin slice of 0.15g, and is coated with the ethyl cellulose in the one side of tablet, 60 ℃ of oven dry;
4), the cooling after carry out packing, after the assay was approved the warehouse-in.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101156248A CN101461832A (en) | 2007-12-18 | 2007-12-18 | Bioadhesive paster for treating mouth ulcer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101156248A CN101461832A (en) | 2007-12-18 | 2007-12-18 | Bioadhesive paster for treating mouth ulcer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101461832A true CN101461832A (en) | 2009-06-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007101156248A Pending CN101461832A (en) | 2007-12-18 | 2007-12-18 | Bioadhesive paster for treating mouth ulcer |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102190736A (en) * | 2010-03-18 | 2011-09-21 | 信越化学工业株式会社 | Low-substituted hydroxypropylcellulose and solid preparation comprising the same |
| CN101919799B (en) * | 2009-12-16 | 2012-06-20 | 北京伊斯康科技有限公司 | Novel sustained-release transdermal medicament delivery system |
| CN103191418A (en) * | 2013-04-26 | 2013-07-10 | 海南光宇生物科技有限公司 | Buccal patch for treating dental ulcer by combination of internal and external treatments |
| CN103340912A (en) * | 2013-06-21 | 2013-10-09 | 江苏七0七天然制药有限公司 | Tin-like powder film agent and preparation method thereof |
| CN105497068A (en) * | 2015-12-25 | 2016-04-20 | 张超 | Buccal patch containing artificial bezoar and metronidazole and preparation method of buccal patch |
-
2007
- 2007-12-18 CN CNA2007101156248A patent/CN101461832A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101919799B (en) * | 2009-12-16 | 2012-06-20 | 北京伊斯康科技有限公司 | Novel sustained-release transdermal medicament delivery system |
| CN102190736A (en) * | 2010-03-18 | 2011-09-21 | 信越化学工业株式会社 | Low-substituted hydroxypropylcellulose and solid preparation comprising the same |
| CN103191418A (en) * | 2013-04-26 | 2013-07-10 | 海南光宇生物科技有限公司 | Buccal patch for treating dental ulcer by combination of internal and external treatments |
| CN103191418B (en) * | 2013-04-26 | 2014-07-16 | 海南光宇生物科技有限公司 | Buccal patch for treating dental ulcer by combination of internal and external treatments |
| CN103340912A (en) * | 2013-06-21 | 2013-10-09 | 江苏七0七天然制药有限公司 | Tin-like powder film agent and preparation method thereof |
| CN105497068A (en) * | 2015-12-25 | 2016-04-20 | 张超 | Buccal patch containing artificial bezoar and metronidazole and preparation method of buccal patch |
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Addressee: Ding Yuefang Document name: Notification of before Expiration of Request of Examination as to Substance |
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Open date: 20090624 |