CN101066257A - Licorice extract for treating oral sores - Google Patents
Licorice extract for treating oral sores Download PDFInfo
- Publication number
- CN101066257A CN101066257A CNA2007100059664A CN200710005966A CN101066257A CN 101066257 A CN101066257 A CN 101066257A CN A2007100059664 A CNA2007100059664 A CN A2007100059664A CN 200710005966 A CN200710005966 A CN 200710005966A CN 101066257 A CN101066257 A CN 101066257A
- Authority
- CN
- China
- Prior art keywords
- described method
- net
- mixture
- lozenge
- gelatin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
A method for treating canker sores with oral patches to speed healing and relieve pain. If certain medications are applied to a canker sore using an oral patch that restricts local flow of saliva and delivers the medication for at least 30 minutes and the patches are used for at least two or more hours per day, the method reduces the healing time for canker sores from typical 10-14 days to 2 days. The method can be used with various antimicrobials that speed the healing of canker sores, including penicillin and amoxicillin. The method can also be used with amlexanox and de-glycyrrhizinated licorice extract (DGL) which work by an unknown method. When used with DGL, the method also quickly relives canker sore pain and, if used before commencing a meal, typically relieves pain through a complete meal. A soluble oral patch with DGL is disclosed.
Description
The application for International Application PCT/US02/35399 on May 8th, 2004 enter the China national stage, application number is 02822064.1, denomination of invention is divided an application for " fully recovering and lenitive method quickening with the patch treatment oral ulcer ".
Technical background
For in the oral cavity in time delivering drugs be used for the treatment of health problem in oral cavity or the throat, developed mouth paster.Mouth paster generally includes one or more incomplete dissolved flexible layers, such as inventions such as Anthony and be disclosed in United States Patent (USP) 5,713, and the flexible layer in 852.Another example of mouth paster is DentiPatch, and it has one or more non-dissolubility thermoplastic layers and lignocaine, and by Noven Pharmaceuticals, Inc. sells and provides.
Term " paster " does not comprise and moves around the bead chamber but not stick to the preparation at a place as used herein, such as cough drop or throat lozenge.The preparation that described paster is not fixed together with individual event when also not comprising in remaining on the oral cavity is such as powder, liquid preparation, unguentum, viscous liquid gel or be broken into the tablet or the tablet of powdery or paste when chewing in saliva.On the contrary, described paster comprises the preparation that is formed by adherent gluey aqueous colloidal really, described aqueous colloidal is fixed together with individual event in remaining on the oral cavity time, such as soft, that adhere to, solubility oral cavity paster, it is disclosed in the Application No. of submitting on November 5th, 2,002 10/287 by same inventor, in 843, be hereby incorporated by reference.
The most significant difference is between mouth paster used herein and the other forms of pharmaceutical preparation, the design of mouth paster is in the long relatively time period with medicine, such as 30 minutes or the longer time be discharged in the oral cavity, stick on the point of oral cavity, thereby medicine can reach high concentration along the limit of paster, and in the oral cavity, keep individual event, thereby in the oral cavity, can not be diffused into a plurality of positions for the moment.
In decades, known always Radix Glycyrrhizae (Glycyrrhiza) root comprises the composition that can quicken to cure gastric ulcer.Which kind of composition plays a role and also knows little about it in the licorice.Glycyrrhizic acid (glycyrrhizicacid) is hydrolyzed to enoxolone (glycyrrhetenic acid) in vivo, knownly causes significant physiological action, comprises hypertension.Pass through such as United States Patent (USP) 3,046 when these are sour, after the method described in 195 reduced, the Radix Glycyrrhizae of separating glycyrrhizin (de-glycyrrhizinatedLicorice) of gained was (DGL) still effective to the treatment gastric ulcer.Recent findings, most gastric ulcers are caused by the antibacterial that is called helicobacter pylori (Helicobacter pylori), therefore adopt the medicine antibiotic can treat most of gastric ulcers.Active component in this explanation licorice root extract is an antibacterial, and it disturbs helicobacter pylori or disturbs the interaction of gastric tissue and this bacterium.
In order to treat gastric ulcer, powder DGL swallows with the form of gelatine capsule sometimes.Yet to mix meeting more effective with saliva before swallowing if test has shown DGL.Therefore, masticable DGL tablet and lozenge have been developed.The DGL powders compression is become tablet or lozenge form, when it is chewed, be broken into agglomerates or cream group fast.Even do not chew, when it contacts with saliva, also be dissolved into cream group fast and mix with saliva.The form that all these DGL tablets and lozenge are designed to chew, and gained cream swallowed.The unknown is made mouth paster to licorice root extract.
The India doctor determines that by clinical trial when water several times every day of DGL were gargled back and forth, DGL also was effective for quickening healing of canker sores.Das SK, Gulati AK, Singh VP; The Radix Glycyrrhizae of separating glycyrrhizin in the oral ulcer (De-glycyrrhizinated licoricein aphthous Ulcers); J Assoc Physicians India, 1989; 37:647.DGL is also alleviated the pain of oral ulcer fast and is not made the surrounding tissue numbness.
Other doctors (Weil) have reported that the propolis that utilization is made by Apis successfully quickens healing of canker sores, and described propolis it is believed that to have bactericidal effect.
As what reported in the standard drug list of references, the medicine antibiotic of local application such as tetracycline or penicillin shows, when every day, several was gargled back and forth with liquid form, can quicken healing of canker sores.In addition, antibiotic can powder, the form of unguentum or viscous liquid gel is administered on the oral ulcer every day for several times, and tablet or the tablet form that perhaps can be dissolved into liquid or mastic fast are placed in the oral cavity, as by Hau at United States Patent (USP) 6, disclosed such in 248,718.Except tetracycline and penicillin, other antibiotic such as amoxicillin (amoxicillin) also show when with the same manner local application effectively.Product that oral ulcer cures be can quicken during other local applications that have been in the news and antibacterial such as hydrogen peroxide, carbonyl diamine peroxide, chlorhexidine gluconate and the hydryllin diphenhydramine (diphenhydramine) at least a research comprised.
Can alleviate the seriousness of oral ulcer but not quicken such as the anti-inflammatory medicine of 17-hydroxy-11-dehydrocorticosterone and cure.
Summary of the invention
By test, the inventor finds, when adopting licorice medicinal herbs extract to treat oral ulcer, by using mouth paster that medicine is remained in the oral cavity or near as much as possible hour of every day of sore spot.Utilize paster keep locally applying to medicine on the oral ulcer in 2 days time every day only about half of hourage, but not only use tablet, gel, unguentum or liquid every day 6 times, last 2 days, with the result from be close to always invalid change into almost always effective.By to rapid and consistent the using of each oral ulcer, the persistent period of each oral ulcer 10-14 days when not treating usually reduce to the paster of licorice root extract and day and night use behind half the hourage 2 days.For little or acute oral ulcer, using every day few was effective to 2 hours.
Relatively little destruction or modify the microbe colony in the ulcer and significantly do not destroy the same microorganism in other places in the oral cavity might be enough to make ulcer to be cured.The inventor finds that this destruction must be kept the time of part in fact by utilizing paster every day, and described paster discharges medicine in time to reach high speed effectiveness.
The inventor also finds: when the extract of licorice was fixed on the oral ulcer director in 15 minutes with mouth paster, oral ulcer pain disappeared, and its surrounding tissue does not have feeling of numbness.The extract of separating glycyrrhizin of licorice (De-glycyrrhizinated extract) extract also plays lenitive effect.Pain relief continues, and has the sufficiently long time to have a meal simultaneously and has meal and do not have pain to finish.
On the one hand, the present invention is used for the treatment of the manufactured goods of oral ulcer for a kind of with the mouth paster form, and described paster is discharging medicine when when saliva in the human mouth contacts more than 30 minutes, and described medicine is a kind of medicament that quickens the oral ulcer healing; Instruct user that paster was remained in its oral cavity 2 hours every day at least or the more time with the treatment oral ulcer.Described medicine can be DGL, can be licorice root extract.Described medicine can be the extract of propolis or propolis.Described paster can comprise adhesive ingredients fixing and the release medicine.Described adhesive ingredients can be the glue that is dissolved in saliva, such as xanthan gum, Konjac glucomannan (konjac gum), gelatin or locust bean gum.
On the other hand, the present invention is used for the treatment of oral ulcer alleviating the manufactured goods that oral ulcer pain need not to make the surrounding tissue numbness for a kind of with the mouth paster form, and described paster is when when saliva in the human mouth contacts, at this medicine of release more than 30 minutes.Instruct user on oral ulcer or near the oral ulcer place, to use them with alleviating pain.Described medicine can be the extract of licorice, also can be DGL.Paster can comprise the adhesive ingredients that is dissolved in the saliva, such as xanthan gum, Konjac glucomannan, gelatin or locust bean gum.
On the other hand, the present invention is a kind of mouth paster, when it is fixed in the human mouth, remains in the oral cavity as individual event, and can not be diffused into a plurality of positions in the oral cavity for the moment and discharge licorice root extract.The release of described extract is sustainable more than 30 minutes.Described paster comprises adhesive ingredients, such as the glue that is dissolved in the saliva, and for example arabic gum, carrageenan, xanthan gum, Konjac glucomannan, agar, gelatin or locust bean gum.
The accompanying drawing summary
Fig. 1 a illustrates the side view of consoluet mouth paster.
Fig. 1 b illustrates the top view of same mouth paster.
Fig. 2 illustrates a plurality of conventional non-dissolved mouth pasters that cover on the oral ulcer.
Detailed Description Of The Invention
Fig. 1 illustrates a kind of consoluet mouth paster.It has the texture of similar chewing gum.It is made with slow dissolved aqueous colloidal, thereby in the oral cavity sustainable at least 1 to 6 hour usually.Described paster can tablet or lozenge or wafer or other any required shapes make.Preferred shape is the thin lenticular as shown in Fig. 1 a.The detailed description of paster and how making by same inventor is disclosed in the Application No. of submitting on November 5th, 2,002 10/287,843, and its content is hereby incorporated by reference.
For paster is dissolved in the saliva very lentamente, mix the binding agent that slowly is dissolved in the saliva.After testing the binding agent that discovery feature is good comprise carrageenan (preferred κ), with the xanthan gum of Konjac glucomannan combination, and agar.Another available glue is arabic gum.Other to enumerate similar glue, also should work such as locust bean gum and guar gum with the similar performance of Konjac glucomannan.
Except making paster is dissolved in the oral cavity very lentamente, binding agent also discharges taste by long diffusion and relaxes any tang.As a result, do not need sweeting agent and other to cover the product of strong taste, though some users like a spot of sweeting agent, and other users like adding other tastes.
As the U.S. Patent Application Serial Number of submitting on November 5th, 2,002 10/287,843 is described, and for the licorice root extract of licorice root extract (DGL) form of separating glycyrrhizin, effectively the dry weight ratio is 36% gelatin, 25%DGL, 28% binding agent (as, 23% cellulose fiber peacekeeping, 5% glue adds locust bean gum or Konjac glucomannan as κ carrageenan or xanthan gum) and, randomly, 11% softening agent, as glycerol (glycerol), it prevents bone dry.Add water to 56% of wet mixture.Wet mixture is heated to 200 °F.
The preferable methods of making paster shown in Figure 1 is to utilize the chewing gum manufacturing equipment, with be heated to hydrated mixture more than the glue melt temperature by nozzle ejection to the corn starch mould, allow paster cooling and gel, dry paster, and they are discharged from mould.Paster preferably is dried to water activity level and is lower than 0.8, so that paster can not become mildewed or the other biological body.Paster is with packing to prevent absorbing aqueous vapor from air.
Perhaps, be not that hydrated mixture is deposited on the corn starch mould, but the array deposition that described mixture is dripped with viscous heat is on the high temperature thermoplastic sheet or the coating scraps of paper.Allow drop cool off, yet in hothouse or baking box, make plastic sheet or the coating scraps of paper drying that has drop on it, be lower than 0.8 up to water activity level.With the production marketing that also is attached on plastics or the paper, and the user draws back it on plastics or paper.
Fig. 2 illustrates the non-dissolved mouth paster of a plurality of routines, and described paster comprises permeable spongy layer 1 and non-permeable level and smooth outer 2.Mouth paster covers on the oral ulcer 3 of people's cheek 4.Spongy layer 1 can be fibrous, so that fubril stretches out from the surface, and the viscosity liner of joint cheek.Fiber can comprise non-wrought mat, such as cotton pad or synthetic pad, and the synthetic pad of preferred hydrophilic.Outer 2 is preferably level and smooth, so that shifting out of paster minimize, and can form from any flexible thermoplastic plastics.Or by utilizing the high viscosity liquid medicine from sponge, slowly ooze out, or comprise that by using the slow dissolved binding agent of gelatin combines medicine with sponge such as above-mentioned any glue, thus medicine is remained in the sponge 1.But glue is dissolved in hot mixt precision processing in the water in sponge, cools off gel then.The size of preferred paster is 24mm * 18mm, one deck of paster or two-layerly comprise red pigment so that its inside as the oral cavity is painted.
In addition, other any mouth pasters as known in the art also can use.
For the medicine in paster to be placed, above-mentioned anyly all can use.Utilize licorice root extract to present significant advantage, can use every day, and find to be free from side effects because its amount is the individual than medicine antibiotic.DGL preferred amount in each paster that continues 1 to 6 hour is 95mg.The individual has to consume mouth paster more than 10 reaching the dosage of 1g DGL, and this remains the very appropriate dosage of treatment gastric ulcer.Yet because DGL concentrates on the oral ulcer, therefore described treatment is effective for quickening healing of canker sores.
Below provide with soft, that adhere to, the conclusion that solubility oral cavity paster tests that have 95mg DGL.
Pain relief: before dining, utilize the DGL paster 10-15 minute, and alleviated the pain of oral ulcer, and if use up until the beginning of having meal, typical dining overall process is kept in pain relief.Around tissue, there is not numb effect.
Every day access times: the time of using every day, the longer the better.User's report, utilize 2 or DGL paster still less every day on the oral ulcer of establishing, and whenever puts up sheet and continue 1-4 hour, then inoperative usually.User's report, utilize 4-9 to open the DGL paster every day on the oral ulcer of establishing, and then succeeds usually.When ulcer had just begun also not grow, general 1-4 puted up sheet and just can deal with problems.
Continue to use the time of DGL paster:, then use and to interrupt in case the user uses DGL and thorn sense and continuing on the ulcer to have more than 4 hours from DGL.Report is arranged, in case ulcer pain and people interrupt using paster no longer, then ulcer can recur.No longer continue to use 24 hours after the pain in ulcer, then ulcer no longer recurs again.
Early find early treatment:, then need shorter treatment if the user early finds early treatment to oral ulcer.Ulcer begins with little otch usually.Some users report, if before oral ulcer has any pain, they just use a DGL paster to the otch 1-4 hour, then can not develop into oral ulcer from otch.Other several times, ulcer before its pain, begin to feel viscous layer certain the point on become too thin.Some user's reports are so far put if they use a DGL paster, then can not develop oral ulcer.Some user's reports, if when oral cavity ulcer is very little and they just begin to use paster during pain hardly, only need 24 hours treatment time, if but they wait until that always ulcer and tomato seed are general when big, then need 48 hours treatment time could begin healing.
The tongue treatment: for the tongue treatment, the DGL paster that most of users will discharge DGL is bonded at the most close tooth.This especially worked at night.
Support: the user who has support is administered to paster on the support, and described support is positioned at the opposite of oral ulcer, thereby makes paster in most of time contact oral ulcer, and adheres on tooth and the support.Along with paster is softening, it sink to support.Paster can be dissolved out from support in 3-9 hour fully.At this moment, it supplies to licorice root extract on the ulcer all the time.
Although above specific embodiments of the present invention is described, scope of the present invention should not be so limited, and is only limited by claim.
Claims (50)
1. a manufacturing is used for the method at the tack mouth paster of human mouth delivering drugs, comprising:
(a) mixing contains medicine, is used to form the composition of the hydrophilic porous net that has the disintegrate rate in saliva and the mixture of solvent, and described net remains solid under human oral temperature;
(b) partially mixed thing is deposited on the smooth thin slice forms drop; With
(c) surpassing drying composite under the temperature of solvent cryogenic temperature, thereby cause drop to shrink, and the composition that is used in the formation net forms hydrophilic porous net, become the single solid structure of medicine in its hole, thereby the generation mouth paster, wherein said mouth paster can be attached to the mucomembranous surface in oral cavity.
2. the described method of claim 1, wherein before deposited mixture, described mixture is heated to the gelation activation temperature, and net process of gelation when comprising cooling forms.
3. the described method of claim 1 comprises further paster is packed in the packing that wherein said thin slice has constituted the part of packing.
4. the described method of claim 1, wherein net contains the hot gel that melting temperature is higher than human mouth temperatures.
5. the described method of claim 1, wherein mixture also contains under human mouth temperatures the molecule for the hydrophilic polymer of liquid, and described hydrophilic polymer to form under the room temperature be the heat-convertible gel of gel.
6. the described method of claim 5, wherein hydrophilic polymer contains polypeptide or protein.
7. the described method of claim 6, wherein hydrophilic polymer is the gelatin that extracts from animal tissue.
8. the described method of claim 1, wherein thin slice comprises plastic sheet.
9. the described method of claim 8 further is included on the thin slice and adds a cover around the paster sealing.
10. the described method of claim 1 further comprises to mixture and adds plasticizer.
11. the described method of claim 10, wherein plasticizer is non-vapo(u)rability plasticizer.
12. the described method of claim 11, wherein plasticizer is a glycerol.
13. the described method of claim 1, wherein said solvent is a water.
14. it is 250 gelatin that the described method of claim 1, the composition that wherein is used to form hydrophilic porous net are selected from the higher gelatin of food glue, agar, carrageenin, kappa carrageen glue, Konjac glucomannan, locust bean gum and xanthan gum, collagen, gelatin, synthetic water gel, two block copolymerization polypeptide amphipathic molecule, carboxymethyl cellulose, hydroxy methocel, polyacrylic acid, hydrophilic complex carbohydrate or polysaccharide, cellulose, pectin, starch, maltodextrin, viscosity and Bo Lumu intensity.
15. the described method of claim 1, the composition that wherein is used to form hydrophilic porous net contains two or more hydrophilic polymeric bodies.
16. the described method of claim 15, wherein to be selected from the higher gelatin of agar, carrageenin, kappa carrageen glue, Konjac glucomannan, locust bean gum and xanthan gum, collagen, gelatin, synthetic water gel, two block copolymerization polypeptide amphipathic molecule, carboxymethyl cellulose, hydroxy methocel, polyacrylic acid, hydrophilic complex carbohydrate or polysaccharide, cellulose, pectin, starch, maltodextrin, viscosity and Bo Lumu intensity be 250 gelatin to hydrophilic polymer.
17. the described method of claim 1, wherein mixture is in step (c) drying, and condition is to form the mouth paster with center and peripheral, and wherein the center is thicker than the edge.
18. the mouth paster that each described method of claim 1-17 is made.
19. a manufacturing is used for the method for the tack mouth paster of human mouth, comprising:
(a) mix and to comprise the composition that is used to form the hydrophilic net and the mixture of solvent, described net remains solid under human mouth temperatures;
(b) mixture is deposited on the smooth thin slice, condition and amount are the drops that forms raw material; With
(c) drying composite, condition are the mouth pasters that drop contraction and formation have center and peripheral, and wherein the center is thicker than the edge, thereby produce mouth paster, and wherein said mouth paster can be attached to the mucomembranous surface in oral cavity.
20. it is 250 gelatin that the described method of claim 19, the composition that wherein is used to form hydrophilic porous net are selected from the higher gelatin of agar, carrageenin, kappa carrageen glue, Konjac glucomannan, locust bean gum and xanthan gum, collagen, gelatin, synthetic water gel, two block copolymerization polypeptide amphipathic molecule, carboxymethyl cellulose, hydroxy methocel, polyacrylic acid, hydrophilic complex carbohydrate or polysaccharide, cellulose, pectin, starch, maltodextrin, viscosity and Bo Lumu intensity.
21. the described method of claim 19 further is included in before the mixture deposition, heating blends is at least 140 degrees Fahrenheits but be lower than the temperature of mixture boiling point, and at the temperature deposit mixture of at least 140 degrees Fahrenheits.
22. it is 250 gelatin that the described method of claim 19, the composition that wherein is used to form hydrophilic porous net are selected from the higher gelatin of agar, carrageenin, kappa carrageen glue, Konjac glucomannan, locust bean gum and xanthan gum, collagen, gelatin, synthetic water gel, two block copolymerization polypeptide amphipathic molecule, carboxymethyl cellulose, hydroxy methocel, polyacrylic acid, hydrophilic complex carbohydrate or polysaccharide, cellulose, pectin, starch, maltodextrin, viscosity and Bo Lumu intensity.
23. the described method of claim 19, the amount that wherein is deposited on mixture in the drop are 0.8 gram.
24. the described method of claim 19, wherein plasticizer adds in the mixture of step (a).
25. the described method of claim 24, wherein plasticizer is non-vapo(u)rability plasticizer.
26. the described method of claim 25, wherein plasticizer is a glycerol.
27. the described method of claim 19, wherein mixture in step (c) to be higher than the temperature drying of solvent cryogenic temperature.
28. the described method of claim 19, wherein solvent is a water.
29. mouth paster by each described method manufacturing of claim 19-28.
30. a manufacturing be used in human mouth through the time send the lozenge of collagen method, comprising:
(a) mix the mixture contain the composition, tropocollagen molecule and the water that are used to form the hydrophilic porous net that has the disintegrate rate in saliva, described net remains solid under human mouth temperatures, and wherein collagen exists with 30% to 80% dry weight concentrations;
(b) heating blends; With
(c) cooling mixture, thus the composition that causes forming net constitutes hydrophilic porous net, becomes the single solid structure that has collagen in the hole.
31. the described method of claim 30, wherein said net is formed by the gelation process that cooling step produces.
32. the described method of claim 30, wherein said gel are the gelatin that extracts from animal tissue.
33. the described method of claim 30 further is included between heating steps and the cooling step, hot mixt is deposited in the mould, and carries out cooling step with the mixture in the mould.
34. the described method of claim 33, wherein mould is smooth hard plastic film.
35. be used for sending the lozenge of collagen, comprise to oral injury:
(a) become under absent populations' cavity temperature the perforated web of the single solid structure of fusing; With
(b) be positioned at the tropocollagen molecule of web pores;
Wherein lozenge is the collagen of dry weight between 30% to 80%.
36. the described lozenge of claim 35, wherein collagen is by partial hydrolysis.
37. the described lozenge of claim 35, wherein collagen is the gelatin from animal proteinum.
38. the described lozenge of claim 35, wherein net is hydrophilic.
39. the described lozenge of claim 35, wherein net contains the hot gel that melting temperature is higher than human mouth temperatures.
40. the described lozenge of claim 35, wherein net contains at least a hydrogel that is selected from Konjac glucomannan, xanthan gum, locust bean gum, agar and carrageenin.
41. the described lozenge of claim 35, wherein net contains complex carbohydrate.
42. the described lozenge of claim 41, wherein hot gel are to be dissolved in to cool off then in the hot water to form the elasticity-Konjac glucomannan of plasticity gel and the mixture of xanthan gum.
43. the described lozenge of claim 35, wherein net contains cellulose.
44. send the lozenge of collagen to oral injury for one kind, form by following ingredients:
(a) collagen of 30-80%,
(b) food binding agent of 5-50% and
(c) other composition of 0-50%.
45. the described lozenge of claim 44, wherein collagen is by partial hydrolysis.
46. the described lozenge of claim 44, wherein collagen is the gelatin from animal proteinum.
47. the described lozenge of claim 44, wherein food binding agent contains at least a dietary fiber and food glue.
48. the described lozenge of claim 47, wherein dietary fiber contains cellulose fibre.
49. the described lozenge of claim 47, wherein food glue contains at least a hydrogel that is selected from Konjac glucomannan, xanthan gum, locust bean gum, agar and carrageenin.
50. the described lozenge of claim 44, wherein food binding agent contains complex carbohydrate.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33291601P | 2001-11-05 | 2001-11-05 | |
| US60/332,916 | 2001-11-05 | ||
| US60/344,577 | 2001-12-28 | ||
| US10/236,289 | 2002-09-04 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB028220641A Division CN1309425C (en) | 2001-11-05 | 2002-11-05 | Treating canker sores with patches to speed healing and relieve pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101066257A true CN101066257A (en) | 2007-11-07 |
Family
ID=38879038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007100059664A Pending CN101066257A (en) | 2001-11-05 | 2002-11-05 | Licorice extract for treating oral sores |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101066257A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103191418A (en) * | 2013-04-26 | 2013-07-10 | 海南光宇生物科技有限公司 | Buccal patch for treating dental ulcer by combination of internal and external treatments |
-
2002
- 2002-11-05 CN CNA2007100059664A patent/CN101066257A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103191418A (en) * | 2013-04-26 | 2013-07-10 | 海南光宇生物科技有限公司 | Buccal patch for treating dental ulcer by combination of internal and external treatments |
| CN103191418B (en) * | 2013-04-26 | 2014-07-16 | 海南光宇生物科技有限公司 | Buccal patch for treating dental ulcer by combination of internal and external treatments |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5686094A (en) | Controlled release formulations for the treatment of xerostomia | |
| US20050136112A1 (en) | Oral medicament delivery system | |
| WO2004043351A2 (en) | Soluble oral patch with collagen and interlaced active ingredients | |
| US20040136923A1 (en) | Edible film for relief of cough or symptoms associated with pharyngitis | |
| CN101466369B (en) | Oral patch with salt of glycyrrhetinic acid water soluble at human mouth temperatures | |
| CN101708176A (en) | Solid film, rapidly dissolvable in liquids | |
| AU2009217366A1 (en) | Treating canker sores with patches to speed healing and relieve pain | |
| US20020172712A1 (en) | Antiemetic, anti-motion sustained release drug delivery system | |
| JP3064417B2 (en) | Controlled release formulations and methods | |
| CN1394598A (en) | Dosage form with crispness coating and soft kernel | |
| US7201930B2 (en) | Licorice root extract oral patch for treating canker sores | |
| EP1532973A2 (en) | Water-soluble film for oral use | |
| CN101066257A (en) | Licorice extract for treating oral sores | |
| US20070098648A1 (en) | Treating mouth sores caused by dental braces with blobs of hydrophilic gums | |
| CN1735393A (en) | Soluble oral patch with collagen and interlaced active ingredients | |
| KR100967363B1 (en) | Preparing methods of starch gel for controlled release of functional ingredients | |
| CN1108160C (en) | Medicine for curing stomatocace and its preparation method | |
| CN1106835C (en) | Chinese medicine film and its preparation | |
| CN1113148A (en) | powdered medicine for treatment of laryngopathy and its preparation method | |
| CN109999123A (en) | The drug and preparation method thereof for treating canker sore | |
| CN1064812A (en) | Produce the method for medicine for external use and health care medicine with a kind of " organic shale " | |
| MXPA06007010A (en) | Oral medicament delivery system comprising collagen-based fibrous matrix |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Open date: 20071107 |