CN1524548A - Liquid traditional Chinese medicine for treating skin disease and its preparation process - Google Patents
Liquid traditional Chinese medicine for treating skin disease and its preparation process Download PDFInfo
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- CN1524548A CN1524548A CNA031110622A CN03111062A CN1524548A CN 1524548 A CN1524548 A CN 1524548A CN A031110622 A CNA031110622 A CN A031110622A CN 03111062 A CN03111062 A CN 03111062A CN 1524548 A CN1524548 A CN 1524548A
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Abstract
A Chinese herbal soup preparation for treating dermatopathy and method of preparation, characterized in that the ingredients of the preparation are, flavescent sophora root, yellow-corktree bark, cnidium fruit, paipunine, hairy vein agrimony each 30g, root of red rooted saliva, wasp's nest, goldthread root, astragalus root, gentian root, chinaberry bark, rhubarb horsetails, knotgrass, giant knotweed rhizome each 20g, black catechu 15g, and boneol 5g. The method of preparation comprises the steps of, extracting using 30-40% ethanol, negative compression, filtering, sterilizing, split charging to obtain flushing agent and spray. The herbal soup according to the invention possesses the appreciable effects of eradiating and inhibiting pathogenic organism, protecting skin and mucous membrane, and improving resisting power.
Description
Affiliated technical field the present invention relates to the plant pharmaceutical formulation, a kind of dermopathic Chinese medicine liquor and preparation method thereof that is used for the treatment of.
Background technology common skin disease comprises the infection of surface skin and mucosal tissue, as tinea cruris, the tinea manus and pedis of various fungal infection, the vaginitis of gynecological's pilosity, chronic cervicitis etc.In recent years, because antibiotic abusing, drug resistance, pathogen that body is produced in various degree produce Drug resistance in various degree, also cause the dysbacteriosis in the woman vagina simultaneously, lost physiological self purification, suffered from various gynopathic probability and increased the women.Though this commercially available quasi drugs is a lot of, but great majority are chemosynthesis and the compound preparation that the variable concentrations hormones is arranged, short run effect is obvious, but relapse rate can rise gradually any more, its main cause is that local environment is damaged, the pH value of vagina is increased, be suitable for breeding, the growth of pathogen, and cause recurrence or infection again.
Summary of the invention the purpose of this invention is to provide dermopathic Chinese medicine liquor of a kind of treatment and preparation method, it is characterized in that material component is: Radix Sophorae Flavescentis, Cortex Phellodendri, Fructus Cnidii, the Radix Stemonae, each 30g of Herba Agrimoniae, Radix Salviae Miltiorrhizae, Nidus Vespae, Rhizoma Coptidis, the Radix Astragali, Radix Gentianae, Cortex Meliae, Radix Et Rhizoma Rhei, hold, each 20g of Rhizoma Polygoni Cuspidati, catechu 15g, Borneolum Syntheticum 5g.With former medicine decoction pieces, get the raw materials ready by above-mentioned component and weight, except that catechu and Borneolum Syntheticum, with concentration be 30-40% ethanol by solvent and solute weight ratio soak at 6: 1, behind the percolation, squeeze the juice, get supernatant 50-60 ℃ negative pressure and concentrate, add in the concentrated solution Borneolum Syntheticum, catechu and an amount of distilled water and make and reach finished product concentration, contain crude drug 35%/100ml liquor.
Chinese medicine liquor of the present invention has obviously the effect of killing, suppress pathogen, also has the effect of protection skin, mucosal tissue, raising resistance simultaneously, is the dermopathic best natural medicine of this class of treatment.
The specific embodiment is treated dermopathic Chinese medicine liquor, comprise spray and irrigation as exterior-applied formulation, it is characterized in that material component is: Radix Sophorae Flavescentis, Cortex Phellodendri, Fructus Cnidii, the Radix Stemonae, each 30g of Herba Agrimoniae, Radix Salviae Miltiorrhizae, Nidus Vespae, Rhizoma Coptidis, the Radix Astragali, Radix Gentianae, Cortex Meliae, Radix Et Rhizoma Rhei, hold, each 20g of Rhizoma Polygoni Cuspidati, catechu 15g, Borneolum Syntheticum 5g.Preparation method is with former YAOJING choosing, make decoction pieces, get the raw materials ready by above-mentioned component and weight, except that catechu and Borneolum Syntheticum, be that the ethanol of 30-40% is in solvent and 4: 1 ratio of solute weight ratio earlier with concentration, 18-24 ℃, soaked former medicine decoction pieces 150-170 hour, take out the solute decoction pieces that soaks, evenly the shop is gone in the percolator, and the 30-40% ethanol that the quite former medicine weight of reuse is 2 times joins in the former medicine solute and continues percolation, squeezes the juice, slagging-off, with soak, percolate and expressed juice mix, gained extracting solution precipitation 24 hours is got supernatant 50-60 ℃ negative pressure and is concentrated, reclaim ethanol, test the concentrated solution total amount, in concentrated solution, add Borneolum Syntheticum, catechu and an amount of distilled water, replenish the moisture that is absorbed by decoction pieces, make medicinal liquid reach finished product concentration, every 100ml liquor contains crude drug 35%, pH value is 3.5-4, brown liquid filters, sterilization, packing: get finished product in the 2ml injector, 30ml aerosol apparatus.
Treat the usage and the consumption of dermopathic Chinese medicine liquor: it is characterized in that 1, irrigation: the administration of intravaginal injector, each 2ml, every day early, evening twice, one week of medication is a course of treatment; 2, spray: be used for percutaneous drug delivery, clean the affected part before the medication, dry, evenly spray this spray, press the injection knob is 1ml at every turn, and every day 3-5 time, a week is a course of treatment.
The curative effect checking
Clinical efficacy statistical table (1)
The clinical diagnosis standard that the women suffers from various vaginitiss, pruritus vulvae, chronic cervicitis is that vaginal secretions increases, or abnormal flavour, cervix uteri hypertrophy, hyperemia, edema, cervical erosion, the chemical examination pathogen positive are arranged.
Clinical efficacy is the result show: Chinese medicine liquor of the present invention is to the treatment of the various inflammation of above-mentioned gynecological through a course of treatment, and effective percentage reaches more than 99%, cure rate 75%; Through the treatment of two courses of treatment, effective percentage is 100%, and cure rate is more than 96%.
Clinical treatment tinea cruris, tinea manus and pedis, beriberi efficacy result see Table face 2:
Clinical efficacy statistical table (2)
The medicine basic test
1, bacteriostatic test
Escherichia coli, staphylococcus aureus, Candida albicans, the bacterium pearl provides by Institute of Basic Medical Sciences, Liaoning Province.Get Chinese medicine liquor of the present invention by dilution method gradually, observe fungistatic effect, the medicinal liquid of variable concentrations is added accomplished fluently 0.5cm and in the hole of inoculation medium (plate), perform labelling, put into 37 ℃ of incubators, cultivated 24 hours, observe the bacteriostatic diameter effect and see following table (2) for details:
(2) bacteriostatic test
Result of the test shows, the Mlc that liquor of the present invention is minimum is that to contain crude drug be 2.1675%, has very strong bacteriostasis equally.
2, go out infusorian test
Trichomonal vaginitis derives from the trouble trichomonal vaginitis women's of PLA's the 202nd hospital-based outpatient obstetrical clinic vaginal secretions, and breed back standby through two generations, then medicinal liquid is added in the standby culture medium that contains pure infusorian alive, make it to become variable concentrations, mirror is observed sterilization effect down, sees following table (3) for details:
(3) infusorian test
The liquor of the present invention that the same proof of this test contains least concentration 2.1675% still has the very strong effect of dripping of going out.
3, mucomembranous irritant test
The Holland white rabbit is provided by Institute of Basic Medical Sciences, Liaoning Province.Flushing liquor of the present invention is standby.
Get 20 female Holland pure lines white rabbits, 15 of body weight 2.5-3kg random packet test group, 5 of matched groups, test group vagina administration every day twice, each 1ml, matched group vagina every day is given twice of distilled water, each 10ml in one week of continuous application, observes vaginal secretions every day.Result of the test: two treated animal vaginas all do not have any abnormal secretion thing, pudendum does not all have redness.Put to death one week back, and perusal two treated animal vaginal mucosaes are smooth, it is congested not have, petechia and edema, and it is complete that the pathological section mirror is observed mucosa down, no cell infiltration, no meat dental tissue hypertrophy.Result of the test shows that liquor of the present invention is to mucocutaneous no any stimulation.
4, acute toxicity test
Get 100 white mice, female, hero half and half, body weight 20-22g, random packet.80 of test group, every day 2 times, the each 1ml of intraperitoneal injection is 3000 times that the adult measures, the adult measures by 2ml/60kg.20 of matched groups, matched group lumbar injection every day distilled water twice, each 1ml, one week of logotype, observe the animal state, to put to death after seven days, the naked eyes mirror is observed the heart, liver, nephridial tissue pathological change down.
The result is in the medication process, and the two treated animal hearts, liver, kidney tunicle are smooth, and no edema is organized in no petechia, and the pathological section mirror is seen down, and two treated animal organizational structuries do not have any change, acellular degeneration, necrosis and hypertrophy.Experimental result shows: liquor of the present invention does not have any acute toxicity effect, is a kind of nontoxic green medicine.
5, chronic toxicity test
Get 120 white mice, female, male half and half, body weight 20-22g is divided into two groups at random, and 100 of test group contrast 20, and test group every day 2 times, the each 0.5ml of intraperitoneal injection is 1500 times that the adult measures; Matched group lumbar injection every day distilled water twice, each 0.5ml, continuous use three months is put to death by stages and in groups, and the naked eyes mirror is observed two groups of hearts, liver, nephridial tissue pathological change down.
Result of the test, all no abnormal performance of two treated animals during the medication, and the heart, liver, kidney naked eyes and mirror are observed all no abnormal change down after the every batch of execution, prove that liquor life-time service of the present invention does not have any toxic action, are a kind of nontoxic green medicine.
Claims (3)
1, the dermopathic Chinese medicine liquor of a kind of treatment is characterized in that material component is: Radix Sophorae Flavescentis, Cortex Phellodendri, Fructus Cnidii, the Radix Stemonae, each 30g of Herba Agrimoniae, Radix Salviae Miltiorrhizae, Nidus Vespae, Rhizoma Coptidis, the Radix Astragali, Radix Gentianae, Cortex Meliae, Radix Et Rhizoma Rhei,
Hold, each 20g of Rhizoma Polygoni Cuspidati, catechu 15g, Borneolum Syntheticum 5g.
2, preparation method according to the dermopathic Chinese medicine liquor of the described treatment of claim 1, comprise spray and irrigation as exterior-applied formulation, it is characterized in that the selected decoction pieces of making of crude drug in whole, get the raw materials ready by above-mentioned component and weight, except that catechu and Borneolum Syntheticum, with the ethanol of concentration 30-40% in solvent and 4: 1 ratio of solute weight ratio, 18-24 ℃ was soaked former medicine decoction pieces 150-170 hour, after seepage, the 30-40% ethanol that the former medicine weight of reuse is 2 times joins in the former medicine and continues seepage, squeeze the juice, slagging-off, extracting solution precipitation 24 hours, getting supernatant 50-60 ℃ negative pressure concentrates, reclaim ethanol, in concentrated solution, add Borneolum Syntheticum, catechu and an amount of distilled water are reached product concentration, contain crude drug 35%/100ml liquor, filter, sterilization, packing: get irrigation in the 2ml injector, get the spray finished product in the 30ml aerosol apparatus.
3, according to the usage and the consumption of the dermopathic Chinese medicine liquor of the described treatment of claim 1: it is characterized in that 1, irrigation: intravaginal administration, each 2ml, every day early, evening twice, one week of medication is a course of treatment; 2, spray: be used for percutaneous drug delivery, every day 3-5 time.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031110622A CN1524548A (en) | 2003-02-27 | 2003-02-27 | Liquid traditional Chinese medicine for treating skin disease and its preparation process |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA031110622A CN1524548A (en) | 2003-02-27 | 2003-02-27 | Liquid traditional Chinese medicine for treating skin disease and its preparation process |
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| CN1524548A true CN1524548A (en) | 2004-09-01 |
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| CNA031110622A Pending CN1524548A (en) | 2003-02-27 | 2003-02-27 | Liquid traditional Chinese medicine for treating skin disease and its preparation process |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100420458C (en) * | 2006-01-20 | 2008-09-24 | 赵庆春 | Externally applied Chinese traditional medicine formulation and its preparing method |
| CN1970020B (en) * | 2006-12-04 | 2010-11-24 | 南京博善医药技术发展有限公司 | A pharmaceutical composition, preparation process and application thereof |
| CN101569728B (en) * | 2008-05-04 | 2012-04-25 | 黄艺华 | Pharmaceutical composition for treating urticaria |
| CN102727847A (en) * | 2012-06-17 | 2012-10-17 | 林华强 | Preparation method for Chinese herbal lotion used for treating excessive-drinking caused trichomonas vaginitis |
| CN102846676A (en) * | 2012-09-16 | 2013-01-02 | 陈正梅 | Medicine for treating cervical erosion |
| CN104606602A (en) * | 2015-01-16 | 2015-05-13 | 中山市第二人民医院 | Traditional Chinese medicine lotion for treating skin diseases and preparation method of traditional Chinese medicine lotion |
| CN104815260A (en) * | 2015-05-29 | 2015-08-05 | 合肥丰瑞隆生物科技有限公司 | Traditional Chinese medicine liquid for treating vaginitis |
| CN111184829A (en) * | 2020-02-21 | 2020-05-22 | 江西林丰药业有限公司 | A plant probiotic antibacterial liquid for treating gynecological inflammation such as cervical erosion, and its preparation method |
-
2003
- 2003-02-27 CN CNA031110622A patent/CN1524548A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100420458C (en) * | 2006-01-20 | 2008-09-24 | 赵庆春 | Externally applied Chinese traditional medicine formulation and its preparing method |
| CN1970020B (en) * | 2006-12-04 | 2010-11-24 | 南京博善医药技术发展有限公司 | A pharmaceutical composition, preparation process and application thereof |
| CN101569728B (en) * | 2008-05-04 | 2012-04-25 | 黄艺华 | Pharmaceutical composition for treating urticaria |
| CN102727847A (en) * | 2012-06-17 | 2012-10-17 | 林华强 | Preparation method for Chinese herbal lotion used for treating excessive-drinking caused trichomonas vaginitis |
| CN102846676A (en) * | 2012-09-16 | 2013-01-02 | 陈正梅 | Medicine for treating cervical erosion |
| CN102846676B (en) * | 2012-09-16 | 2014-07-09 | 陈正梅 | Medicine for treating cervical erosion |
| CN104606602A (en) * | 2015-01-16 | 2015-05-13 | 中山市第二人民医院 | Traditional Chinese medicine lotion for treating skin diseases and preparation method of traditional Chinese medicine lotion |
| CN104815260A (en) * | 2015-05-29 | 2015-08-05 | 合肥丰瑞隆生物科技有限公司 | Traditional Chinese medicine liquid for treating vaginitis |
| CN111184829A (en) * | 2020-02-21 | 2020-05-22 | 江西林丰药业有限公司 | A plant probiotic antibacterial liquid for treating gynecological inflammation such as cervical erosion, and its preparation method |
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