CN107854572B - External traditional Chinese medicine for treating damp-heat stasis type chronic pelvic inflammatory disease pain and preparation method thereof - Google Patents

External traditional Chinese medicine for treating damp-heat stasis type chronic pelvic inflammatory disease pain and preparation method thereof Download PDF

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CN107854572B
CN107854572B CN201711070016.XA CN201711070016A CN107854572B CN 107854572 B CN107854572 B CN 107854572B CN 201711070016 A CN201711070016 A CN 201711070016A CN 107854572 B CN107854572 B CN 107854572B
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张幸华
孙自学
门波
陈建设
李晖
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Henan Hospital Traditional Chinese Medicine Second Affiliated Hospital of Henan University of Traditional Chinese Medicine TCM
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    • A61K36/21Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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    • A61K36/533Leonurus (motherwort)
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Abstract

The invention relates to an external traditional Chinese medicine for treating damp-heat stasis type chronic pelvic inflammatory disease pain and a preparation method thereof, and the traditional Chinese medicine comprises the following preparation raw materials in parts by weight: 26-35 parts of red peony root, 16-25 parts of motherwort, 3-9 parts of frankincense, 12-20 parts of medicinal cyathula root, 6-15 parts of patrinia, 8-14 parts of phellodendron, 25-35 parts of rhizoma corydalis and 25-35 parts of szechwan chinaberry fruit. The motherwort in the formula has the effects of promoting blood circulation to regulate menstruation, inducing diuresis to alleviate edema, and clearing away heat and toxic materials; the red paeony root and the frankincense have the effects of activating blood circulation to stop pain, reducing swelling and promoting granulation, the golden cypress and the patrinia are mainly used for dispelling damp-heat, and the four medicines are used as ministers; the rhizoma corydalis and the szechwan chinaberry fruit are used as assistants for promoting qi circulation and relieving pain and assisting monarch drugs and ministerial drugs to play a role in relieving pain; guiding the medicinal herbs from radix Cyathulae to make the medicinal herbs into the body; the external traditional Chinese medicine can solve the problems that the effect of treating acute pelvic inflammation is poor and the patient is difficult to solve fundamentally, and can effectively relieve pain symptoms caused by damp-heat stasis type chronic pelvic inflammation.

Description

External traditional Chinese medicine for treating damp-heat stasis type chronic pelvic inflammatory disease pain and preparation method thereof
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to an external traditional Chinese medicine for treating damp-heat stasis type chronic pelvic inflammatory disease pain and a preparation method thereof.
Background
Chronic pelvic inflammatory disease is an infectious disease of the female upper genital tract, is a common disease of gynecology and is often seen in women of childbearing age. The clinic visit rate of chronic pelvic inflammatory disease patients accounts for almost 70% of the times of the gynecologic clinic, and the disease has serious influence on the life quality and fertility of women. The disease is caused by the intermingled heat, toxicity and dampness, unrelieved healthy qi, incomplete residual pathogenic factors, wind-cold-damp-heat and insect toxicity, which cause qi stagnation, blood stasis, uterus and uterus vessels accumulation, repeated movement and retreat, qi and blood consumption and lingering and difficult healing. The syndrome differentiation is characterized by a few single syndromes, including damp-heat stagnation, qi stagnation and blood stasis, cold-damp stagnation, qi deficiency and blood stasis, kidney deficiency and blood stasis according to the causes. However, most of the syndromes are damp-heat stagnation, which is caused by the internal invasion of damp-heat pathogen, incomplete residual pathogen, incomplete healthy qi, qi and blood obstruction, internal stagnation of damp-heat stasis, stagnation in uterus and uterine vessels, and pain caused by obstruction, so as to cause salpingemphraxis, hydrops, pelvic adhesion, and ovarian cyst of the salpingemphraxis, resulting in chronic pelvic pain, infertility, etc.
At present, the existing traditional Chinese medicine preparation mainly aims at clearing heat, promoting diuresis, promoting blood circulation and removing blood stasis, and is difficult to improve the damp-heat stasis type chronic pelvic inflammatory disease, so that a traditional Chinese medicine is urgently needed to be developed, and the pain symptom caused by the damp-heat stasis type chronic pelvic inflammatory disease can be effectively relieved.
Disclosure of Invention
Aiming at the problems, the invention provides an external traditional Chinese medicine for treating damp-heat stasis type chronic pelvic inflammatory disease pain and discloses a preparation method thereof.
In order to solve the technical problems, the invention is realized by the following technical scheme:
an external traditional Chinese medicine for treating damp-heat stasis type chronic pelvic inflammatory disease pain is designed, and comprises the following raw materials in parts by weight:
26-35 parts of red peony root, 16-25 parts of motherwort, 3-9 parts of frankincense, 12-20 parts of medicinal cyathula root, 6-15 parts of patrinia, 8-14 parts of phellodendron, 25-35 parts of rhizoma corydalis and 25-35 parts of szechwan chinaberry fruit.
Preferably, the external traditional Chinese medicine is prepared from the following raw materials in parts by weight:
29-32 parts of red peony root, 18-22 parts of motherwort, 5-7 parts of frankincense, 13-17 parts of medicinal cyathula root, 8-12 parts of patrinia, 9-12 parts of phellodendron bark, 28-33 parts of rhizoma corydalis and 28-33 parts of szechwan chinaberry fruit.
Preferably, the external traditional Chinese medicine is prepared from the following raw materials in parts by weight:
26-35 parts of red peony root, 19-24 parts of motherwort, 5-9 parts of frankincense, 12-16 parts of medicinal cyathula root, 9-14 parts of patrinia, 8-12 parts of phellodendron, 25-30 parts of rhizoma corydalis and 29-34 parts of szechwan chinaberry fruit.
Further preferably, the external traditional Chinese medicine is prepared from the following raw materials in parts by weight: 30 parts of red paeony root, 20 parts of motherwort, 6 parts of frankincense, 15 parts of medicinal cyathula root, 10 parts of dahurian patrinia herb, 10 parts of amur corktree bark, 30 parts of rhizoma corydalis and 30 parts of szechwan chinaberry fruit.
The preparation method of the external traditional Chinese medicine mainly comprises the following steps:
pulverizing the above Chinese medicinal materials into fine powder, mixing according to the corresponding raw material ratio, mixing well, taking appropriate amount of Mel as medicinal excipient, mixing with Chinese medicinal fine powder, and making into paste.
The application method of the external traditional Chinese medicine comprises the following steps: the external traditional Chinese medicine with the size of 1 yuan is placed in the center of the plaster and is respectively applied to the Shenque point, Guanyuan point and Mingmen point, the change is carried out for 1 time in 1 day, each application is carried out for 4-6 hours, and 7 days are a treatment course.
The action mechanism of the traditional Chinese medicine raw materials is as follows:
radix Paeoniae Rubra is dry root of Ranunculaceae plant radix Paeoniae Rubra or radix Paeoniae Rubra, also called radix Paeoniae Rubra and radix Paeoniae alba, produced in most regions of China, collected in spring and autumn, removed rhizome, fibrous root and silt, sun-dried, and sliced. Being bitter in property and slightly cold, it enters liver meridian. The main effects are clearing heat and cooling blood, eliminating stasis and relieving pain, and the red peony root has stronger inhibition effect on various pathogenic microorganisms.
Herba Leonuri is fresh or dry aerial part of herba Leonuri of Labiatae, is produced in most regions of China, is wild or cultivated, is usually harvested in summer when stem and leaf are flourishing and flower is not blooming or is just blooming, is removed of impurities, is cleaned, is moistened thoroughly, is cut into segments and is dried. The property of the herb is pungent, bitter and slightly cold, and it enters heart, liver and bladder meridians. The main effects are promoting blood circulation to regulate menstruation, inducing diuresis to alleviate edema, clearing heat and detoxicating.
Olibanum is resin exuded from boswellia serrata belonging to family Burseraceae and its congeneric plant, mainly produced in places such as African Somali and Russia carinata, wild or cultivated, harvested in spring and summer, and the bark of trunk is sequentially cut from bottom to top to allow resin exudation, and coagulated into solid after several days, and then harvested. The property of herbs is pungent, bitter and warm, and they enter heart, liver and spleen meridians. The main effects are activating blood circulation, promoting qi circulation, relieving pain, detumescence and promoting granulation. Olibanum has effects of relieving pain, diminishing inflammation, increasing leukocyte, accelerating excretion of inflammatory exudation, and promoting wound healing.
Radix Cyathulae is the dried root of radix Cyathulae of Amaranthaceae. Collected in autumn and winter, removed of reed heads, fibrous roots and silt, baked or aired to be half-dry, piled and moistened again, and then baked or aired. The herbs have sweet and slightly bitter taste and neutral nature, and enter liver and kidney meridians. Has the main effects of dispelling wind, promoting diuresis, treating dysmenorrhea, activating blood circulation, relieving pain and slightly inducing diuresis.
Herba Patriniae is dry whole plant of Patrinia scabiosaefolia FISCH and Patrinia villosa FIP of Patrinia, is distributed in most regions of the country, mainly produced in the three provinces of Sichuan, Hebei, Henan and northeast, harvested in summer and autumn, pulled up, cleaned by removing silt, and dried in the shade or in the sun. The property of herbs is pungent, bitter and slightly cold, entering stomach, large intestine and liver meridians. The main effects are clearing away heat and toxic material, eliminating carbuncle and pus, removing blood stasis and relieving pain. Herba Patriniae has inhibitory effect on Staphylococcus aureus, Bacillus dysenteriae, typhoid bacillus, Pseudomonas aeruginosa, and Escherichia coli.
Cortex Phellodendri is the dry bark of phellodendron amurense belonging to Rutaceae, and is known as "phellodendron amurense", which is mainly produced in Sichuan, Guizhou, Hubei, Yunnan province, etc., and is prepared by peeling the bark after clearing, removing the rough bark, drying in the sun and flattening. Being bitter and cold in nature, they enter kidney, bladder and large intestine meridians. The main effects are clearing heat and drying dampness, purging fire and removing toxicity, and removing bone-steaming.
Rhizoma corydalis is a perennial herb of corydalis of Papaveraceae, also called corydalis tuber and corydalis tuber, cultivated in most areas of the country, is suitable for growing in nearly neutral or slightly acidic silty soil, sandy soil or sandy soil along two banks of the stream or mountain feet, is warm in nature, is pungent and bitter in taste, and enters heart, spleen, liver and lung channels. Has the main effects of promoting blood circulation, removing blood stasis, promoting qi circulation and relieving pain.
Fructus Toosendan is dry mature fruit of Melia toosendan of Meliaceae, produced everywhere in south China, preferably Sichuan product, collected in winter when fruit is mature, removed of impurities, dried, and smashed when used. Being bitter and cold in nature and with small toxicity, it enters liver, stomach, small intestine and bladder meridians. The main effects are promoting qi circulation and relieving pain, and killing parasites. Fructus Toosendan has inhibitory effect on Staphylococcus aureus and various pathogenic fungi, and also has antiinflammatory and anticancer effects.
The invention has the following positive and beneficial technical effects:
the external traditional Chinese medicine formula compatibility principle of the invention is as follows: motherwort herb has the effects of promoting blood circulation to regulate menstruation, inducing diuresis to alleviate edema and clearing away heat and toxic materials, and is the monarch drug; the red paeony root and the frankincense have the effects of activating blood circulation to stop pain, reducing swelling and promoting granulation, the golden cypress and the patrinia are mainly used for dispelling damp-heat, and the four medicines are used as ministers; the rhizoma corydalis and the szechwan chinaberry fruit are used as assistants for promoting qi circulation and relieving pain and assisting monarch drugs and ministerial drugs to play a role in relieving pain; radix Cyathulae is used as guiding drug to make it act.
The external traditional Chinese medicine can solve the problems that the existing medicine has poor effect on treating acute pelvic inflammation and is difficult to fundamentally solve the disease, and can effectively relieve pain symptoms caused by damp-heat stasis type chronic pelvic inflammation.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Embodiment 1 an external traditional Chinese medicine for treating damp-heat stasis type chronic pelvic inflammatory disease pain is prepared from the following raw materials in parts by weight: 30 parts of red paeony root, 20 parts of motherwort, 6 parts of frankincense, 15 parts of medicinal cyathula root, 10 parts of dahurian patrinia herb, 10 parts of amur corktree bark, 30 parts of rhizoma corydalis and 30 parts of szechwan chinaberry fruit.
The preparation method comprises the following steps: pulverizing the above Chinese medicinal materials into fine powder, mixing, adding Mel as medicinal excipient, and mixing with the fine powder to obtain paste.
Embodiment 2 an external traditional Chinese medicine for treating damp-heat stasis type chronic pelvic inflammatory disease pain is prepared from the following raw materials in parts by weight: 27 parts of red paeony root, 18 parts of motherwort, 3 parts of frankincense, 12 parts of medicinal cyathula root, 8 parts of dahurian patrinia herb, 8 parts of amur corktree bark, 28 parts of rhizoma corydalis and 28 parts of szechwan chinaberry fruit.
The preparation method is the same as that of example 1.
Embodiment 3 an external traditional Chinese medicine for treating damp-heat stasis type chronic pelvic inflammatory disease pain is prepared from the following raw materials in parts by weight: 32 parts of red paeony root, 24 parts of motherwort, 8 parts of frankincense, 18 parts of medicinal cyathula root, 12 parts of dahurian patrinia herb, 12 parts of amur corktree bark, 35 parts of rhizoma corydalis and 35 parts of szechwan chinaberry fruit.
The preparation method is the same as that of example 1.
Embodiment 4 an external traditional Chinese medicine for treating damp-heat stasis type chronic pelvic inflammatory disease pain is prepared from the following raw materials in parts by weight: 27 parts of red paeony root, 24 parts of motherwort, 3 parts of frankincense, 18 parts of medicinal cyathula root, 8 parts of dahurian patrinia herb, 12 parts of amur corktree bark, 28 parts of rhizoma corydalis and 35 parts of szechwan chinaberry fruit.
The preparation method is the same as that of example 1.
Embodiment 5 an external traditional Chinese medicine for treating damp-heat stasis type chronic pelvic inflammatory disease pain is prepared from the following raw materials in parts by weight: 32 parts of red paeony root, 18 parts of motherwort, 8 parts of frankincense, 12 parts of medicinal cyathula root, 12 parts of dahurian patrinia herb, 8 parts of amur corktree bark, 35 parts of rhizoma corydalis and 28 parts of szechwan chinaberry fruit.
The preparation method is the same as that of example 1.
EXAMPLE 6 clinical trial
(1) Clinical data: 150 patients with chronic pelvic inflammatory disease diagnosed and treated by department of procreatics of traditional Chinese medicine of Henan province from 2016 (1 month) to 2017 (1 month) are selected as study objects and are randomly divided into a control group and an observation group. 75 control groups are aged 22-48 years, the shortest disease course is 2 months, and the longest disease course is 9 years. 75 observation groups are 20-52 years old, the shortest disease course is 4 months, and the longest disease course is 7 years. The data of age and disease course of two groups of patients have no statistical significance (P > 0.05) before treatment and are comparable.
(2) Diagnostic criteria:
the Western medicine refers to the diagnosis standard of chronic pelvic inflammatory disease in gynecologic obstetrics. The diagnosis of traditional Chinese medicine refers to the syndrome of dampness-heat stasis in TCM: distending pain in the lower abdomen, profuse leucorrhea, yellow and sticky color, odor, soreness, distending pain or stabbing pain in the lumbosacral part, bitter taste in the mouth, dry throat, pruritus vulvae, scanty and brownish urine, sticky and unsmooth stool, red tongue with ecchymosis, yellow and greasy tongue coating, and slippery and rapid or unsmooth pulse. Eliminating hysteromyoma, cyst, endometriosis, appendicitis, pelvic tuberculosis and patients with malignant tumor; severe liver and kidney insufficiency, and mental diseases.
(3) The treatment measures are as follows:
1. control group: after the injection is admitted, the clindamycin for injection is used for treating the tinidazole, 0.6g of clindamycin for injection is given according to the advice of doctors, and the clindamycin for injection is added into 250ml of normal saline for intravenous drip, and the administration is carried out 1 time a day; tinidazole injection 0.8g is administered by intravenous drip for 1 time per day, and 7 days is 1 treatment course.
2. Observation group: the traditional Chinese medicine acupoint application is added on the basis of the treatment of the control group, and the acupoint application formula comprises the following steps: 30g of red peony root, 20g of motherwort, 6g of frankincense, 15g of medicinal cyathula root, 10g of dahurian patrinia herb, 10g of amur corktree bark, 30g of rhizoma corydalis and 30g of szechwan chinaberry fruit. The traditional Chinese medicine raw materials are firstly ground into fine powder, the fine powder is uniformly mixed according to the corresponding raw material proportion, a proper amount of honey is taken as a medicine excipient, the honey and the fine powder are mixed to form a paste, the external traditional Chinese medicine with the size of 1 yuan of coins is placed in the center of the paste, and is respectively applied to the Shenque point, Guanyuan point and Mingmen point, 1 time of replacement is carried out in 1 day, 4-6 hours are applied to each time, and 7 days are 1 course of treatment. Changes in total efficacy were observed after treatment in both groups of patients.
(4) As a result:
the effective rate of the clinical curative effect observation group is obviously higher than that of the control group (P < 0.05), and the effective rate is shown in table 1.
TABLE 1 comparison of clinical efficacy of patients in control and observation groups after treatment (example)
Figure 262234DEST_PATH_IMAGE001
Example 7 typical case analysis:
(1) li Yi, woman, 37 years old, 2 pregnant and 1 lying-in women, mental clarity, spiritual ability, lower abdominal pain, waist discomfort, leukorrhagia with dark red color, blood clots, red tongue, thin and yellow coating, deep and slippery pulse, oral administration of heat-clearing and detoxifying, blood circulation-promoting and stasis-removing medicines and rectal dropping of traditional Chinese medicines, and simultaneously, the external traditional Chinese medicine patch in the embodiment 1 of the invention is applied to Shenque point, Guanyuan point and Mingmen point 1 time a day. The pain of the patient is relieved after 7 days, no obvious discomfort is caused in the lower abdomen, and the patient is discharged.
(2) Von, female, 28 years old, pregnant 3, 1 birth, plan 2 fetuses, lower abdominal pain after fatiguing before complaint 7 days, tolerance, increased leucorrhea, waist discomfort, gynecological examination prompt: the uterus pressure pain is obvious, the bilateral adnexal area pain, the tongue is slightly red, the coating is thin and yellow, the pulse is deep and smooth, the medicine for clearing heat and detoxicating, promoting blood circulation and removing blood stasis and tonifying the kidney and supplementing qi is orally taken by the doctor, and the external traditional Chinese medicine plaster in the embodiment 1 of the invention is applied to the Shenque point, the Guanyuan point and the Mingmen point 1 time a day. After 8 days, the pain of the patient is relieved, the lower abdomen does not have obvious discomfort, and the patient is discharged.
(3) Wangzhi, woman, age 28, mental clarity, poor spirit, lower abdominal pain with increased leucorrhea in nearly 7 days, cleanliness 2 degrees in leucorrhea examination, gynecological examination: the uterus pressure pain is obvious, the bilateral adnexal area pain, the tongue is slightly red, the coating is thin and yellow, the pulse is deep and smooth, the medicine for clearing heat and detoxicating, promoting blood circulation and removing blood stasis and tonifying the kidney and supplementing qi is orally taken by the doctor, and the external traditional Chinese medicine plaster in the embodiment 2 of the invention is applied to the Shenque point, the Guanyuan point and the Mingmen point 1 time a day. After 10 days, the pain of the patient is relieved, the lower abdomen has no obvious discomfort, and the patient is discharged.
(4) Yang Shi, female, age 26, plan 1 fetus, mental clarity, spiritual vigor, lower abdomen tenesmus and pain, breast distending pain, soreness of waist, increased leucorrhea in nearly 6 days, gynecological examination suggests: the vaginal secretion is increased, the uterus pressure pain is obvious, the bilateral adnexal area is tendered, the tongue is slightly red, the coating is thin and yellow, the pulse is deep and smooth, the medicines for clearing heat and removing toxicity, promoting blood circulation and removing blood stasis and tonifying the kidney and qi are orally taken by the doctor, and the external traditional Chinese medicine plaster in the embodiment 3 of the invention is applied to the Shenque point, the Guanyuan point and the Mingmen point 1 time a day. The pain of the patient is relieved after 7 days, no obvious discomfort is caused in the lower abdomen, and the patient is discharged.
(5) Warm certain, female, age 35, clear mind, spiritual, lower abdominal pain after fatigue before 5 days, tolerance, waist discomfort, self-administration of gynecological Qianjin tablets, no obvious relief of abdominal pain symptoms, red tongue, thin and yellow coating, deep and smooth pulse. Prompting gynecological examination: the vaginal secretion is increased, the uterus pressure pain is obvious, the bilateral adnexal area is tendered, the tongue is slightly red, the coating is thin and yellow, the pulse is deep and smooth, the medicines for clearing heat and removing toxicity, promoting blood circulation and removing blood stasis and tonifying the kidney and qi are orally taken by the doctor, and the external traditional Chinese medicine plaster in the embodiment 4 of the invention is applied to the Shenque point, the Guanyuan point and the Mingmen point 1 time a day. After 8 days, the pain of the patient is relieved, the lower abdomen does not have obvious discomfort, and the patient is discharged.

Claims (4)

1. An external traditional Chinese medicine for treating damp-heat stasis type chronic pelvic inflammatory disease pain is characterized by being prepared from the following raw materials in parts by weight:
29-32 parts of red peony root, 18-22 parts of motherwort, 5-7 parts of frankincense, 13-17 parts of medicinal cyathula root, 8-12 parts of patrinia, 9-12 parts of phellodendron bark, 28-33 parts of rhizoma corydalis and 28-33 parts of szechwan chinaberry fruit.
2. An external traditional Chinese medicine for treating damp-heat stasis type chronic pelvic inflammatory disease pain is characterized by being prepared from the following raw materials in parts by weight:
26-35 parts of red peony root, 19-24 parts of motherwort, 5-9 parts of frankincense, 12-16 parts of medicinal cyathula root, 9-14 parts of patrinia, 8-12 parts of phellodendron, 25-30 parts of rhizoma corydalis and 29-34 parts of szechwan chinaberry fruit.
3. The external traditional Chinese medicine for treating damp-heat stasis type chronic pelvic inflammatory disease pain according to claim 1, is characterized by being prepared from the following raw materials in parts by weight:
30 parts of red paeony root, 20 parts of motherwort, 6 parts of frankincense, 15 parts of medicinal cyathula root, 10 parts of dahurian patrinia herb, 10 parts of amur corktree bark, 30 parts of rhizoma corydalis and 30 parts of szechwan chinaberry fruit.
4. The preparation method of the external traditional Chinese medicine for treating damp-heat stasis type chronic pelvic inflammatory disease pain according to claim 1 or claim 2, which comprises the following steps:
pulverizing the raw materials into fine powder, mixing the raw materials according to the proportion of claim 1 or claim 2, mixing, and mixing with Mel as medicinal excipient to obtain paste.
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