CN103463405B - External-application medicine powder for treating infant pertussis syndrome - Google Patents

Abstract

The invention relates to a pharmaceutical formulation field and specifically relates to external-application medicine powder for treating an infant pertussis syndrome. The external-application medicine powder is characterized in that material medicines are as follows in percent by weight: 7%-10% of mulberry leaves, 7%-10% of asarum, 4%-7% of roasted loquat leaves, 4%-7% of artemisia anomala, 5%-8% of rhizoma imperatae, 3%-6% of mint leaves, 8%-11% of momordica grosvenori, 6%-9% of indigo naturalis, 3%-6% of bitter almond kernels, 6%-9% of caulis perllae, 5%-8% of honeysuckle, 2%-3% of lilies, 3%-5% of scutellaria baicalensis, 4%-6% of radish seeds, 3%-5% of dandelion and 4%-6% of cassia twigs, wherein the 16 material medicines are mixed, dried, and ground into fine powder, sieved through a 120-mesh sieve and filled into a bottle for later use. The external-application medicine powder is used for treating the infant pertussis syndrome and low in cost, has no obvious toxic and side effects, has a higher treatment effective rate and is not easy to have a relapse.

Description

The external application medicated powder for the treatment of child pertussis syndrome

Technical field

The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of external application medicated powder for the treatment of child's pertussis syndrome.

Background technology

As everyone knows, pertussis syndrome is one group of syndrome being difficult to clinically distinguish with pertussis, also known as " class pertussis ".He is not caused by bordetella pertussis, but by comprising caused by other viral microorganisms, wherein modal is adenovirus, and other still have mycoplasma pneumoniae, parapertussis bacillus, respiratory syncytial virus, cytomegalovirus etc.Its clinical treatment, nursing, the course of disease and more after all exist from general respiratory tract infection significantly different, as can not early discovery and process may cause severe complication.Model case can be divided into catarrhal period (1 ~ 2 week), stage of spasmodic cough (2 ~ 4 weeks or longer), convalescent period (4 ~ 12 weeks or longer).Clinical characters is paroxysmal spasmodic cough, and any little stimulation all can cause paroxysmal spasmodic cough to show effect, and with crow sample air-breathing roar during cough end at end, vomiting gastric content is feature.The primary disease course of disease is longer, from onset to the appearance of paroxysmal paroxysmal spasmodic cough, can with low grade fever, cough, sneeze, to shed tears and weak etc., similar cold symptoms.If this phase can treat in time, can effectively symptom management development.Cough starts as monophone dry cough, and heat is stepped back, cough aggravation, and especially to be night very, after paroxysmal spasmodic cough, companion vomits.At present, clinical in specific short, treat mainly doctor trained in Western medicine anti symptom treatment, treatment such as application antibiotics, hormone etc.Have an injection, take medicine especially to infant difficulty comparatively greatly, and easily recur after drug withdrawal.

Summary of the invention

Object of the present invention is exactly to overcome above-mentioned existing technical deficiency, and provide a kind of external application medicated powder for the treatment of child's pertussis syndrome, cost is low, do not have obvious toxic-side effects, treated effect is higher, not easily recurs.

The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of external application medicated powder for the treatment of child's pertussis syndrome, it is characterized in that crude drug composition is by weight percentage: Folium Mori 7 ~ 10%, Herba Asari 7 ~ 10%, process rake leaf 4 ~ 7%, Herba Artemisiae Anomalae 4 ~ 7%, Rhizoma Imperatae 5 ~ 8%, mentha leave 3 ~ 6%, Fructus Momordicae 8 ~ 11%, Indigo Naturalis 6 ~ 9%, Semen Armeniacae Amarum 3 ~ 6%, Caulis Perillae 6 ~ 9%, Flos Lonicerae 5 ~ 8%, Bulbus Lilii 2 ~ 3%, Radix Scutellariae 3 ~ 5%, Semen Raphani 4 ~ 6%, Herba Taraxaci 3 ~ 5%, Ramulus Cinnamomi 4 ~ 6%, dry mixed for above-mentioned 16 taste crude drug, grind and be ground into fine powder, cross 120 mesh sieves, bottle for subsequent use.

The present invention is used for the treatment of child's pertussis syndrome, and cost is low, do not have obvious toxic-side effects, and treated effect is higher, not easily recurs.

Detailed description of the invention

Below in conjunction with embodiment, the invention will be further described:

Embodiment 1:

Adopt Folium Mori, Herba Asari, process rake leaf, Herba Artemisiae Anomalae, Rhizoma Imperatae, mentha leave, Fructus Momordicae, Indigo Naturalis, Semen Armeniacae Amarum, Caulis Perillae, Flos Lonicerae, Bulbus Lilii, Radix Scutellariae, Semen Raphani, Herba Taraxaci, Ramulus Cinnamomi raw material be prepared from.Its component (% by weight) is often paid as Folium Mori 9.3, Herba Asari 9.1, is processed rake leaf 6.5, Herba Artemisiae Anomalae 6.5, Rhizoma Imperatae 7.3, mentha leave 5.3, Fructus Momordicae 9.7, Indigo Naturalis 7.2, Semen Armeniacae Amarum 4.8, Caulis Perillae 7.9, Flos Lonicerae 6.6, Bulbus Lilii 2.4, Radix Scutellariae 4.4, Semen Raphani 4.8, Herba Taraxaci 3.4, Ramulus Cinnamomi 4.8.Get the 139 grams of oven dry of above-mentioned 16 taste raw material total amount, grind and be ground into fine powder, cross 120 mesh sieves, bottle for subsequent use.I.e. obtained " the external application medicated powder for the treatment of child pertussis syndrome ".Child's pertussis syndrome onset starts, first clean and dry infant umbilicus eye position, get " the external application medicated powder for the treatment of child pertussis syndrome " about 10 grams and be placed in umbilicus eye and umbilicus position near the eyes, then with fixing umbilicus eye and the umbilicus medicated powder near the eyes of applying ointment or plaster, change medicated powder every day once.To get it filled again 30 grams, powder Ovum Gallus domesticus album furnishing, 3 medicine cakes, prick number hole with toothpick.After pressing Tiantu, Danzhong, Feiyu acupuncture point respectively, then 3 medicine cakes are affixed on above-mentioned three acupuncture points respectively, and with moxa stick moxibustion 2 ~ 3 minutes, can tolerate with infant, fixing with applying ointment or plaster respectively after moxa stick moxibustion.Every day carries out once, applies ointment or plaster after fixing 1 ~ 2 hour at every turn, then takes off respectively, and seven days is a course for the treatment of, be applied to Clinical symptom and sign disappear after, then medicated powder is applied umbilicus coordinate Yao Bingjiu three acupuncture point the next day once, apply four times.

Folium Mori dispelling wind and heat pathogens of the present invention, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving.For anemopyretic cold, lung-heat type cough, dizziness headache, conjunctival congestion is dim-sighted; Herba Asari cures mainly: dispel the wind, cold expelling, and row water, has one's ideas straightened out.Control air-cooled headache, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia; Process the cough-relieving of rake leaf, lung heat clearing stomach function regulating, lowering the adverse-rising QI to resolve phlegm.Cure mainly lung-heat phlegmatic cough, hemoptysis, epistaxis, gastric heat is vomitted the sound of vomiting; Herba Artemisiae Anomalae is bitter, and temperature, enters the heart, spleen channel, have removing blood stasis and stimulate the menstrual flow, effect of healing up sore and subduing swelling.For controlling amenorrhea lump in the abdomen, chest and abdomen swelling and pain, puerperal blood stasis, traumatic injury, the diseases such as incised wound is hemorrhage, Yong Du burning swelling; Rhizoma Imperatae is cold in nature, sweet in the mouth.Return lung, stomach, small intestine meridian.There is heat clearing away, diuresis, removing heat from blood, the effect of hemostasis; Mentha leave dispelling wind and heat pathogens, clearing throat, rash are antipruritic, anti-inflammatory analgesic; Fructus Momordicae sweet in the mouth is cool in nature, returns lung, large intestine channel, has nourishing the lung to arrest cough, and effect of promoting the production of body fluid to quench thirst is applicable to lung-heat or xeropulmonary cough, pertussis and summer-heat impairment of body fluid thirsty etc.; The blue or green eliminating pathogen in the liver of Indigo Naturalis color, loose stagnated fire of the five organs, in solution, the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels stores and accumulates wind heat.Cure the wound a cold speckle, and tell spitting of blood dysentery, children's shies, the red heat of infantile malnutrition with fever, Fu's carbuncle skin ulcer, Serpentis dog poison; Semen Armeniacae Amarum cures mainly function sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation.For cough and asthma, fullness in the chest abundant expectoration, blood deficiency Tianjin is withered, dryness of the intestine constipation; Caulis Perillae with regulating the flow of QI to ease the stomach, pain relieving, antiabortive.Be generally used for treatment chest and diaphragm painful abdominal mass vexed, gastralgia, belch is vomitted, frequent fetal movement; Flos Lonicerae sweet cold fragrance, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, also kind removing summer-heat blood poison, for various febrile disease, as fever of the body, dermexanthesis; Bulbus Lilii sweet in the mouth, property are put down, and have effect of nourishing the lung to arrest cough, clearing away heart-fire for tranquillization, clearing away heat and cooling blood, looks improving and the skin nourishing; Radix Scutellariae heat clearing and damp drying, eliminating fire and detoxication, antiabortive, cooling blood for hemostasis.Effect: blood pressure lowering, calmness, anti-microbial effect, to blood fat and blood glucose effect.Diuresis, to relieving asthma; The enough therapeutic method to keep the adverse QI flowing downwards Dingchuan of Semen Raphani, eliminate indigestion and phlegm.Clinical being usually used in controls cough phlegm dyspnea, stagnation of QI due to dyspepsia, abdominal distention uncomfortable in chest, weighs etc. after dysentery; Herba Taraxaci nature and flavor are sweet, bitter, cold, have heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, antiinflammatory, removing heat from blood, diuresis, function of gallbladder promoting, hypocatharsis, stomach invigorating; Ramulus Cinnamomi property and flavor of peppery and warm, has the effect of expelling cold and relieving exterior syndrome.The ingenious prescription of 16 taste Chinese herbal medicine, scientific compatibility, between medicine, mutual coordinative role, plays the specially good effect of child's pertussis altogether.

The each raw material of the present invention also can the embodiment that mixes of ratio (percentage by weight) listed by according to the form below realize, and its processing technique is identical with embodiment 1.

The clinical trial carried out below in conjunction with my institute is done further, to describe in detail to the present invention:

1, case selection: be diagnosed as in pertussis syndrome child from my institute over 2007 ~ 2011 years and select 66 examples, man 38 example, female 28 example; Wherein≤June 19 example, June ~ 1 years old 17 example, 1 ~ 2 years old 16 example, 2 ~ 3 years old 14 example.The course of disease is the shortest 4 days, the longest 16 days.Its diagnosis is according to typical clinical manifestations, especially spasmodic cough, crow sample echo, vomiting three large symptoms, and reference laboratories checks that leukocyte obviously increases, and increases based on lymphocyte, and etiological examination result, to differentiate with pertussis.

2, tcm diagnosis standard " the disease of tcm Standardization of diagnosis and curative effect " issued with reference to State Administration of Traditional Chinese Medicine.

3, Therapeutic Method: the external application medicated powder first getting treatment child pertussis syndrome ready, child's pertussis syndrome onset makes a definite diagnosis (catarrhal period) in early days, and more early effect is better.First clean and dry infant umbilicus eye position, get " the external application medicated powder for the treatment of child pertussis syndrome " about 10 grams and be placed in umbilicus eye and umbilicus position near the eyes, then with fixing umbilicus eye and the umbilicus medicated powder near the eyes of applying ointment or plaster, change medicated powder every day once.To get it filled again 30 grams, powder Ovum Gallus domesticus album furnishing, 3 medicine cakes, prick number hole with toothpick.After pressing Tiantu, Danzhong, Feiyu acupuncture point respectively, then 3 medicine cakes are affixed on above-mentioned three acupuncture points respectively, and with moxa stick moxibustion 2 ~ 3 minutes, can tolerate with infant, fixing with applying ointment or plaster respectively after moxa stick moxibustion.Every day carries out once, applies ointment or plaster after fixing 1 ~ 2 hour at every turn, then takes off respectively, within seven days, is a course for the treatment of, applies three courses for the treatment of, then medicated powder is applied umbilicus coordinate Yao Bingjiu three acupuncture point the next day once, apply four times.

4, therapeutic effect: evaluation of efficacy criteria;

Effective: infant paroxysmal spasmodic cough, and all disappear with Clinical symptom and sign such as crow sample air-breathing roars when cough stops, temperature recovery is normal, and numeration of leukocyte and Lymphocyte subset counting recover normal

Effective: infant paroxysmal spasmodic cough, and obviously alleviate with Clinical symptom and sign such as crow sample air-breathing roars when cough stops, even show effect again, numeration of leukocyte and Lymphocyte subset count normal high level or a little more than normal value.

Invalid: infant Clinical symptom and sign and lab testing invalid.

5, therapeutic effect: use the present invention 66 example, carry out treatment effectiveness evaluation according to criterion of therapeutical effect, effective+be effectively total effective rate.Effective 49 examples, effective 14 examples, invalid 3 examples, total effective rate is 95.5%.

Claims (1)

1. treat the external application medicated powder of child's pertussis syndrome for one kind, it is characterized in that: crude drug composition is by weight percentage, Folium Mori 7 ~ 10%, Herba Asari 7 ~ 10%, process rake leaf 4 ~ 7%, Herba Artemisiae Anomalae 4 ~ 7%, Rhizoma Imperatae 5 ~ 8%, mentha leave 3 ~ 6%, Fructus Momordicae 8 ~ 11%, Indigo Naturalis 6 ~ 9%, Semen Armeniacae Amarum 3 ~ 6%, Caulis Perillae 6 ~ 9%, Flos Lonicerae 5 ~ 8%, Bulbus Lilii 2 ~ 3%, Radix Scutellariae 3 ~ 5%, Semen Raphani 4 ~ 6%, Herba Taraxaci 3 ~ 5%, Ramulus Cinnamomi 4 ~ 6%, dry mixed for above-mentioned 16 taste crude drug, grind and be ground into fine powder, cross 120 mesh sieves, bottle for subsequent use.