CN104225344A - Chinese herbal preparation for treating chronic nephropyelitis and preparation method thereof - Google Patents

Chinese herbal preparation for treating chronic nephropyelitis and preparation method thereof Download PDF

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CN104225344A
CN104225344A CN201410540263.1A CN201410540263A CN104225344A CN 104225344 A CN104225344 A CN 104225344A CN 201410540263 A CN201410540263 A CN 201410540263A CN 104225344 A CN104225344 A CN 104225344A
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herba
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smilacis glabrae
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段永胜
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Abstract

The invention discloses a Chinese herbal preparation for treating chronic nephropyelitis and a preparation method thereof. The preparation is prepared by using the following main raw materials by weight: 25-45 parts of rush, 5-12 parts of medical stone, 18-25 parts of plantain herb, 6-12 parts of codonopsis pilosula, 6-12 parts of rhizoma smilacis glabrae, 6-15 parts of field thistle, 20-40 parts of lalang grass rhizome, 15-25 parts of shepherd's purse, 15-25 parts of polygonum aviculare and 6-10 parts of ural licorice root tip. The Chinese herbal preparation is remarkable in effect, short in treatment course, free of tolerance and free of toxic and side effects. The chronic nephropyelitis is not prone to reappear after a patient is cured.

Description

The Chinese medicine preparation for the treatment of chronic pyelonephritis and method for making
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicine preparation and method for making thereof for the treatment of chronic pyelonephritis.
Background technology
Chronic pyelonephritis is the chronic inflammatory disease that bacteriological infection kidney causes, and pathological changes mainly invades renal interstitial and renal pelvis, renal calices tissue.Continue due to inflammation the infringement carrying out or repeatedly cause renal interstitial, renal pelvis, renal calices, form cicatrix, so that kidney generation atrophy and occur dysfunction.Patient may only have the soreness of waist and (or) low grade fever, can not have the dysurea of obvious urinary tract infection, frequent micturition and symptoms of urgency, and its main manifestations is that nocturia increases and has a small amount of leukocyte and albumen etc. in urinating.Patient has urinary tract infection medical history that is long-term or recurrent exerbation, can occur uremia late.Some patients has predisposing factor to exist, as urinary tract obstruction, deformity, nephroptosis and vesico-ureteric reflux etc.Clinical manifestation: 1. systemic toxicity profiles symptom.Fear of cold, heating, weak, inappetence.2. local symptom.The soreness of waist, lumbago and costovertebral angle kowtow pain.3. irritation sign of bladder.Frequent micturition, urgent micturition, dysurea and dysuria.And urinary tract infection medical history exceedes half a year more than, antibacterial therapy poor effect.
Urgent, chronic nephropyeltis all belongs to the traditional Chinese medical science " stranguria " category, so that women's sickness rate is the highest after marriage." stranguria " has dividing of pyretic stranguria, stranguria caused by urinary stone, stranguria with blood, stranguria marked by chyluria, stranguria caused by overstrain, but is classified as the large class of deficiency and excess two clinically more, and damp syndrome is based on damp and hot, and clearing away heat-damp and promoting diuresis is paid attention in treatment; Deficiency syndrome are suffered from a deficiency of the kidney based on spleen, and tonifying speen and tonifying kidney is worked as in treatment.Because primary disease is more obstinate, protracted inflammation, what have is for years on end, vigour of causing injury, and body resistance against diseases weakens unavoidably, and treatment often needs the long period.But concrete remedy measures, should note stage.When healthy energy is strengthened in the early stage, based on eliminating evil, the medicine of clearing away heat-damp and promoting diuresis should be taken, can prove effective very soon, more in addition strong agent is assisted, then can reach healing.Still exist to heresy in mid-term, just seeing and declining, heresy is just being divided and is being striven, eliminating evilly should hold concurrently with righting, see that how much heresy has, just hindering how much, to send on medicine should carefully respectively be looked after at prescription, administration schedule also should be considered proper, take heat-clearing and diuresis-promoting drug several days, after disease amelioration, take vital base and primordial QI consolidating agent again, be used alternatingly, treating both the principal and secondary aspects of a disease, disease is easy to cure.To the later stage, be short of physical strength, resistance against diseases decays, often easily acute attack, now measure, must guard against when showing effect, excessively emphasizing dampness removing heat clearing away, to dampen the vigour of only depositing.Should when showing effect, suitable is suppressed, and sees alleviation, namely throws the medicine of foster kidney qi, adhere to taking, if goodbye acute attack, still repeatedly treat with this side, disease-resistant function will be cumulative, the probability of recurrence reduces, and patient's condition alleviates gradually, until no longer recur, thoroughly fully recovers.Examine inspection is completely normal, must adhere to after treatment, and compatibility and incompatibility of drugs is tired, avoids wind and cold to cause flu, in case recurrence.2. 1. Therapeutic Principle selects sensitive bacteria to Drug therapy (1) and toxicity is less, and all has the antibiotic of higher concentration in excess of the kidney matter and urine; 2. comparatively long-term therapy (4 weeks or 6 weeks) is adopted, to reaching the object of thorough bacteria removal; 3. as can not bacteria removal and urinary tract infection acute attack repeatedly, the antimicrobial therapeutics of low dosage long-term therapy be adopted, at least medication more than 1 year; When 4. there is uremia, should renal function protecting be noted, avoid drug accumulation poisoning, again can bacteria growing inhibiting well.(2) selection of medicine.The lighter can with bactrim, quinolones or to add the semi-synthetic penbritin of beta lactamase restrainer oral, and severe one needs drug combination and intravenous administration, adds tazobactam or imipenum adds Cilastatin Sodium as piperacillin.3. drug safety.Avoid the medicine of kidney damage, such as: streptomycin, gentamycin, ionic contrast agent etc.
Application publication number CN 103041203 A(application number 201210565882.7) Chinese patent literature disclose one and treat chronic pyelonephritis Chinese medicine formula, mainly contain following component and make by weight ratio: major ingredient: Radix Codonopsis 15 grams, the Rhizoma Atractylodis Macrocephalae 12 grams, 18 grams, Poria, 18 grams, the Radix Rehmanniae, Cortex Moutan 9 grams, Rhizoma Alismatis 15 grams, Semen Cuscutae 24 grams, Semen Plantaginis 12 grams of Herba Polygoni Avicularis 15 grams, Herba Dianthi 15 grams, Flos Lonicerae 18 grams, Herba Leonuri 30 grams, Rhizoma Imperatae 30 grams, Radix Glycyrrhizae uralensis 9 grams, adjuvant: water 500mL.Application publication number CN 102370853 A(application number 201110327150.X) Chinese patent literature disclose a kind of Chinese medicine for the treatment of chronic pyelonephritis, it is characterized in that it is made up of the component of the material medicine proportioning of following weight: Radix Astragali 40-45g, Radix Angelicae Sinensis 20-25g, Radix Rehmanniae 30-35g, Fructus Corni 20-23g, Rhizoma Dioscoreae 20-23g, Cortex Moutan 10-12g, Poria 10-12g, Rhizoma Alismatis 10-12g, Radix Aconiti Lateralis Preparata 10-12g, Radix Sophorae Flavescentis 20-25g, Herba Patriniae 60-65g, Herba Taraxaci 60-65g, Herba Cirsii 30-35g, Herba Houttuyniae 30-35g, Radix Glycyrrhizae 10-12g.Application publication number CN 102614445 A(application number 201210039859.4) Chinese patent literature disclose a kind of Chinese medicine for the treatment of chronic pyelonephritis, it by Rhizoma Curculiginis, Radix Angelicae Sinensis, Fructus Amomi, Radix Morindae Officinalis, Rhizoma Alismatis, Herba Cirsii by certain part by weight array become.
Chronic pyelonephritis is more obstinate, and the course of disease is longer, and what have does not heal for many years.At present, use Western medicine as better for treatment chronic pyelonephritis curative effect in antibiotic, but life-time service antibiotic, antibacterial can produce drug resistance, or enters in cell, makes antibiotic lose sterilizing ability, easy recurrent exerbation, Chinese medicine can resist drug resistance, does not have toxic and side effects, but the Chinese medicine preparation curative effect for the treatment of chronic pyelonephritis is not obvious at present.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of Chinese medicine preparation for the treatment of chronic pyelonephritis and preparation method thereof.Be very effective of the present invention, short treating period, not easily recurs, and can not produce drug resistance, and have no side effect.
Technical scheme of the present invention is:
The Chinese medicine preparation for the treatment of chronic pyelonephritis, takes off the primary raw material medicine stating weight proportion and is prepared from: Medulla Junci 25-45, Maifanitum 5-12, Herba Plantaginis 18-25, Radix Codonopsis 6-12, Rhizoma Smilacis Glabrae 6-12, Herba Cirsii 6-15, Rhizoma Imperatae 20-40, Herba Capsellae 15-25 ， Herba Polygoni Avicularis 15-25, Radix Glycyrrhizae uralensis 6-10.
The Chinese medicine preparation for the treatment of chronic pyelonephritis, preferred scheme is, takes off the primary raw material medicine stating weight proportion and is prepared from: Medulla Junci 28-40, Maifanitum 7-10, Herba Plantaginis 20-23, Radix Codonopsis 8-11, Rhizoma Smilacis Glabrae 7-10, Herba Cirsii 8-12, Rhizoma Imperatae 25-32, Herba Capsellae 17-22 ， Herba Polygoni Avicularis 16-21, Radix Glycyrrhizae uralensis 7-9.
The Chinese medicine preparation for the treatment of chronic pyelonephritis, the scheme be more preferably is, takes off the primary raw material medicine stating weight proportion and is prepared from: Medulla Junci 34, Maifanitum 9, Herba Plantaginis 22, Radix Codonopsis 10, Rhizoma Smilacis Glabrae 8, Herba Cirsii 11, Rhizoma Imperatae 29, Herba Capsellae 20 ， Herba Polygoni Avicularis 18, Radix Glycyrrhizae uralensis 8.
Present invention also offers the preparation method Chinese medicine preparation of aforementioned therapies chronic pyelonephritis being made pharmaceutically acceptable decoction, powder, thick paste agent and pill.
The preparation method of described decoction is:
(1) Rhizoma Smilacis Glabrae is first used the vexed 1-4 of water hour (preferably vexed 2.5 hours), the consumption of water is the consumption of the 1/25-1/8(preferred water of Rhizoma Smilacis Glabrae weight is 1/10 of Rhizoma Smilacis Glabrae weight), after use the vexed 2-5 of wine hour (preferably vexed 3 hours), the consumption of wine is the consumption of the preferred wine of 1/20-1/8(of Rhizoma Smilacis Glabrae weight is 1/7 of Rhizoma Smilacis Glabrae weight), dry;
(2) Maifanitum is smashed be placed in marmite, add the water (preferably adding the water of 2.5 times amount Maifanitum weight) of 2-5 times amount Maifanitum weight, first boil to boiling with big fire, turn little fire and decoct 1-3 hour (preferably decocting 2 hours) afterwards, leach medicinal liquid;
(3) Herba Plantaginis is first installed with gauze bag, then join in above-mentioned marmite with step (1) gained Rhizoma Smilacis Glabrae and Radix Codonopsis, Herba Cirsii, Rhizoma Imperatae, Herba Polygoni Avicularis, Radix Glycyrrhizae uralensis, add the water (preferably adding the water of medical material gross weight added by 3.5 times amount) of medical material gross weight added by 2.5-6 times amount, first boil to boiling with big fire, rear turn of little fire decocts 0.5-1.5 hour (preferably decocting 0.8 hour), leaches medicinal liquid;
(4) Medulla Junci and Herba Capsellae are joined in above-mentioned marmite, add the water (preferably adding the water of 2.8 times amount medical material gross weights) of 2-5 times amount medical material gross weight, first boil to boiling with big fire, rear turn of little fire decocts 10-40 minute (preferably decocting 28 minutes), leaches medicinal liquid;
(5) step (2), step (3) and step (4) gained medicinal liquid are merged, obtain decoction.
The preparation method of described powder is:
(1) each crude drug is removed impurity, pulverize respectively and grind to form fine powder, cross 120-180 mesh sieve (preferred mistake 160 mesh sieve);
(2) step (1) gained fine powder is dropped into mixing and blending machine fully to mix, sterile packaged, often wrap 6 grams.
The preparation method of described thick paste agent is:
(1) Rhizoma Smilacis Glabrae is first used water moistening 1-4 hour (preferably vexed 2.5 hours), the consumption of water is the consumption of the 1/25-1/8(preferred water of Rhizoma Smilacis Glabrae weight is 1/10 of Rhizoma Smilacis Glabrae weight), after use the vexed 2-5 of wine hour (preferably vexed 3 hours), the consumption of wine is the consumption of the preferred wine of 1/20-1/8(of Rhizoma Smilacis Glabrae weight is 1/7 of Rhizoma Smilacis Glabrae weight), dry;
(2) Maifanitum is smashed be placed in marmite, add the water (preferably adding the water of 2.5 times amount Maifanitum weight) of 2-5 times amount Maifanitum weight, first boil to boiling with big fire, turn little fire and decoct 1-3 hour (preferably decocting 2 hours) afterwards, leach medicinal liquid;
(3) Herba Plantaginis is first installed with gauze bag, then join in above-mentioned marmite with step (1) gained Rhizoma Smilacis Glabrae and Radix Codonopsis, Herba Cirsii, Rhizoma Imperatae, Herba Polygoni Avicularis, Radix Glycyrrhizae uralensis, add the water (preferably adding the water of medical material gross weight added by 3.5 times amount) of medical material gross weight added by 2.5-6 times amount, first boil to boiling with big fire, rear turn of little fire decocts 0.5-1.5 hour (preferably decocting 0.8 hour), leaches medicinal liquid;
(4) Medulla Junci and Herba Capsellae are joined in above-mentioned marmite, add the water (preferably adding the water of 2.8 times amount medical material gross weights) of 2-5 times amount medical material gross weight, first boil to boiling with big fire, rear turn of little fire decocts 10-40 minute (preferably decocting 28 minutes), leaches medicinal liquid;
(5) step (2), step (3) and step (4) gained medicinal liquid are merged, decompression, to be concentrated into relative density be the preferred relative density of 1.0-1.4(is 1.3) clear paste, then add adjuvant and mix well, seal and get final product in dress aseptic bottle.
The preparation method of described pill is:
(1) each crude drug is removed impurity, after drying, these medicines are mixed together and are ground into fine powder, 140-220 object sieve (preferably using 160 object sieves), mixing;
(2) refined honey is joined in step (1) gained fine powder, the weight of refined honey be the 1/2-1.2 of medicine gross weight doubly (weight of preferred refined honey is 0.8 times of medicine gross weight), make every ball weight be 0.1-0.4g(preferably every ball weight be 0.3g) small honey pill.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Medulla Junci: base is former: be the dry stem pith of rush family plant Medulla Junci.Stem pith, containing multiple phenanthrene derivatives, has been separated and has obtained: Medulla Junci diphenol, 6-methyl Medulla Junci diphenol, juncusol, 2,6-dihydroxy-1,7-dimethyl-5-vinyl-9,10-dihydro is luxuriant and rich with fragrance, 2,7-dihydroxy-1,8-dimethyl-5-vinyl-9,10-dihydro is luxuriant and rich with fragrance, and 2,8-dihydroxy-1,6-dimethyl-5-vinyl-9,10-dihydro is luxuriant and rich with fragrance, 8-hydroxyl-2-methoxyl group-1,6-dimethyl-5-vinyl-9,10-dihydro is luxuriant and rich with fragrance.The property of medicine: sweet, light, is slightly cold.GUIXIN, lung, small intestine meridian.Function cures mainly: clearing away heart-fire, diuresis.For vexed insomnia, the puckery pain of oliguria, aphtha of the mouth and tongue.Modern study effect: there is anastalsis.Treatment Child epidemic parotitis, evident in efficacy.Control epistaxis, have effective.Also chronic glomerulonephritis can be treated, common cold of gastrointestinal type.Sore throat can be controlled.
Maifanitum: base is former: be Acid-intermediate igneous rock rocks beschtauite.Composition: Maifanitum main component has silicon dioxide, aluminium oxide, ferrum oxide, ferrous oxide, magnesium oxide, calcium oxide, sodium oxide, potassium oxide, titanium dioxide, phosphorus pentoxide, manganese oxide, carbon dioxide, and the trace element such as fluorine, sulfur, strontium, barium, copper, zinc.The property of medicine: " detailed outline ": " sweet, temperature, nontoxic." function cures mainly: removing toxic substances and promoting granulation, damp eliminating spleen invigorating.Cure mainly carbuncle carbuncle on the back, acne, eczema, beriberi, miliaria, finger is chapped, chloasma, toothache, oral ulcer, rheumatic arthralgia, lumbago and backache, chronic hepatitis, gastritis, dysentery, diabetes, neurasthenia, wound is red and swollen, hypertension, senile sclerosis of blood vessels, tumor, lithangiuria.Generally make health product.Compatibility and incompatibility of drugs: superfine end need be ground during external application, otherwise easily cause pain.
Herba Plantaginis: base is former: be the dry herb of Plantaginaceae plant Herba Plantaginis or Plantago depressa Willd.Herba Plantaginis herb contains ursolic acid, positive hentriacontane, cupreol, stigmasterol, β-paddy alcohol cetylate, stigmasteryl palmitate, aucubin, Herba Plantaginis glycosides A, B, C, D, E, F, remove rhamnose different Syring vulgaris phenol glycoside B, remove rhamnose Syring vulgaris phenol glycoside, different Syring vulgaris phenol glycoside, Syring vulgaris phenol glycoside, people from sky grass glycoside A, different unicorn glycoside, unicorn glycoside.The property of medicine: sweet, cold.Return liver, kidney, lung, small intestine meridian.Function cures mainly: clearing away heat and promoting diuresis, eliminates the phlegm, removing heat from blood, removing toxic substances.For edema oliguria, the puckery pain of pyretic stranguria, heat-damp in summer dysentery, phlegm-heat cough, hematemesis and epistaxis, carbuncle sore tumefacting virus.
Radix Codonopsis: base is former: be the dry root of Campanulaceae Radix Codonopsis, element flower Radix Codonopsis or radix codonpsis tangshen etc.Radix Codonopsis has containing sterols: hitodesterol, stigmasterol, hitodesterol-β-D-Glucose glycoside, stigmasterol-β-D-Glucose glycoside, α-Herba Spinaciae sterone, stigmasterone etc.Sugar and glycoside have: inulin, fructose, four kinds of heteropolysaccharide containing fructose.Syringin, β-D-Glucopyranose. hexanol glycoside, α-D-fructofuranose ethanol glycoside.Alkaloid and nitrogen containing component have: choline, normal-butyl allophanate, codopiloic acid, 5-hydroxy-2-hydroxymethylpyridine, nicotine.Volatile ingredient has: caproic acid, enanthic acid, sad, n-nonanoic acid, dodecoic acid, Azelaic Acid, tetradecylic acid, pentadecanoic acid, hexadecylic acid, stearic acid, octadecadienoic acid, 2,4-nonadienoic acids, Pentadecane, α-curcumene, n-heptadecane, n-octadecane, AI3-36122, positive 21 alkane, positive docosane, methyl myristate, pentadecanoic acid methyl ester, methyl palmitate, methyl stearate, octadecadienoic methyl, pinene, ethyl palmitate, methyl caprylate.Still containing triterpenes and other compositions: alnulin, Taraxeryl acetate, suberone; Atractyloide II, III; Syringic aldehyde, vanillic acid, 2-furan carboxylic esters, codonolactone, 5 hydroxymethyl furfural, 5-methoxyl group furfural.In addition, the also 17 seed amino acid property of medicine such as 14 kinds of inorganic elementss such as iron content, zinc, copper, manganese and aspartic acid, threonine, serine, glutamic acid: sweet, flat.Return spleen, lung meridian.Function cures mainly: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.
Rhizoma Smilacis Glabrae: base is former: be the rhizome of Liliaceae smilax plant smilacis glabra.Composition: rhizome is containing volatile oil: 49 kinds of compositions such as n-hexadecanoic methyl ester; Phenolic acids: 3-0-caffeoyl shikimic acid, ferulic acid; Steroidal saponin, flavonoid glycoside etc.The property of medicine: sweet, light, flat.Return liver,kidney,spleen, stomach warp.Function cures mainly: removing damp-heat, lets out turbid removing toxic substances, easing joint movement.Cure mainly syphilis, stranguria with turbid discharge, have loose bowels, muscles and bones spasm and pain, beriberi, carbuncle, skin ulcer tinea, scrofula, goiter and mercurialism.
Herba Cirsii: base is former: be aerial parts or the root of Compositae artichoke plant field thistle.Composition: wounded in the battle herb is containing flavone: rutin, linarin, i.e. robinin, that is acacetin-7-rhamnose glucoside, acacetin, apigenin, astragalin; Phenolic acids: protocatechuic acid, chlorogenic acid, caffeic acid; Sterols: taraxasterol etc.The property of medicine: sweet, micro-hardship, cool.Return liver, taste warp.Function cures mainly: cooling blood for hemostasis, removing toxic substances and promoting subsidence of swelling.Cure mainly hematuria, stranguria with blood, hemoptysis, spit blood, epistaxis, has blood in stool, dysentery, metrorrhagia and metrostaxis, traumatic hemorrhage, swollen ulcer drug.Rhizoma Imperatae: base is former: be the dry rhizome of grass Herba Imperatae.Chemical composition: rhizome Arundoin, Cylindrin, Coixol, fernenol, simiarenol, Isoarborinol, Anemonin; Also containing sterols: stigmasterol, cupreol, campesterol, saccharide, volume sucrose, glucose and a small amount of fructose, xylose; Simple acids: citric acid, oxalic acid and malic acid.The property of medicine: sweet, cold.Return lung, stomach, urinary bladder channel.Function cures mainly: cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria, acute nephritis edema.
Herba Capsellae: base is former: be the herb of Cruciferae shepherd's purse platymiscium Herba Capsellae.Composition: herb is containing flavonoid: dihydrofisetin, Quercetin-3-methyl ether, gossypetin pregnancy ether, diosmin etc.Fatty acid: Palmic acid, Fumaric acid, oxalic acid, tartaric acid, malic acid etc.Alkaloids: choline, acetylcholine, sinapic acid choline ester. etc.The property of medicine: sweet, light, cool.Return liver, spleen, urinary bladder channel.Function cures mainly: cool liver hemostasis, suppressing the hyperactive liver improving eyesight, clearing away heat-damp and promoting diuresis.Cure mainly haematemesis, epistaxis, spitting of blood, hematuria, metrorrhagia, conjunctival congestion and pain of eye, retinal hemorrhage, hypertension, dysentery, oedema due to nephritis, chyluria.
Herba Polygoni Avicularis: base is former: be the dry aerial parts of Liao section Zhi Wu Herba Polygoni Avicularis.Herb is containing flavones ingredient: Quercetin, avacularin, quercitrin, vitexin, isovitexin, luteolin, rhamnetin-3-half milk extract glycoside, hyperin etc.Also containing Coumarins composition: umbelliferone, scopoletin.Again containing acid ingredient: ferulic acid, sinapic acid, vanillic acid, syringic acid, melilotic acid, P-coumaric acid, P-hydroxybenzoic acid, gentisic acid, caffeic acid, protocatechuic acid, gallic acid, p-hydroxyphenylaceticacid, chlorogenic acid, salicylic acid, benzoaric acid, dextrorotation cachou extract, oxalic acid, silicic acid and methionine, proline, serine, threonine, tyrosine, phenylalanine, cystine, arginine, valine, glycine, leucine, lysine, isoleucine, tryptophan etc.Also containing glucose, fructose, sucrose, water soluble polysaccharide.The property of medicine: bitter, is slightly cold.Return urinary bladder channel.Function cures mainly: inducing diuresis for treating stranguria syndrome, and parasite killing is antipruritic.For bladder pyretic stranguria, oliguria with reddish urine, drenches the puckery pain of drop, skin eczema, pudendal pruritus leukorrhagia.
Radix Glycyrrhizae uralensis: base is former: be tip part or the radicula of the root of glycyrrhizic legume.Radix Glycyrrhizae root and rhizome, containing glycyrrhizin, is potassium, the calcium salt of glycyrrhizic acid.Still containing liquiritin, liquiritigenin, isoliquiritin, different Radix Glycyrrhizae unit, neoliquriitin, neoisoliquiritin etc.The property of medicine: sweet; Cold.GUIXIN, liver, spleen channel.Function cures mainly: eliminating fire and detoxication, inducing diuresis for treating stranguria syndrome.Main pyretic stranguria, oliguria, pain in penis, in the heart accumulated heat.
Chinese medicine preparation scientific formula provided by the invention, products obtained therefrom taking convenience.In addition, excellent results of the present invention also shows:
1, instant effect, curative effect is reliable;
2, can not drug resistance be produced, and have no side effect;
3, there is clearing away heat-damp and promoting diuresis, inducing diuresis for treating stranguria syndrome, removing toxic substances and promoting subsidence of swelling, invigorating the spleen and replenishing QI, the effects such as spleen invigorating lung benefiting, for treatment chronic pyelonephritis Be very effective;
4, cure rate is high, not easily recurs.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the Chinese medicine preparation for the treatment of chronic pyelonephritis, the primary raw material medicine getting following weight is prepared from: Medulla Junci 25g, Maifanitum 5g, Herba Plantaginis 18g, Radix Codonopsis 6g, Rhizoma Smilacis Glabrae 6g, Herba Cirsii 6g, Rhizoma Imperatae 20g, Herba Capsellae 15g, Herba Polygoni Avicularis 15g, Radix Glycyrrhizae uralensis 6g.
The preparation method of the Chinese medicine preparation decoction for the treatment of chronic pyelonephritis is:
(1) Rhizoma Smilacis Glabrae is first used vexed 1 hour of water, the consumption of water is 1/25 of Rhizoma Smilacis Glabrae weight, vexed 2 hours of rear wine,
The consumption of wine is 1/20 of Rhizoma Smilacis Glabrae weight, dries;
(2) Maifanitum is smashed be placed in marmite, add the water of 2 times amount Maifanitum weight, first boil to boiling with big fire, turn little fire and decoct 1 hour afterwards, leach medicinal liquid;
(3) Herba Plantaginis is first installed with gauze bag, then join in above-mentioned marmite with step (1) gained Rhizoma Smilacis Glabrae and Radix Codonopsis, Herba Cirsii, Rhizoma Imperatae, Herba Polygoni Avicularis, Radix Glycyrrhizae uralensis, add the water of medical material gross weight added by 2.5 times amount, first boil to boiling with big fire, rear turn of little fire decocts 0.5 hour, leaches medicinal liquid;
(4) Medulla Junci and Herba Capsellae are joined in above-mentioned marmite, add the water of 2 times amount medical material gross weights, first boil to boiling with big fire, rear turn of little fire decocts 10 minutes, leaches medicinal liquid;
(5) step (2), step (3) and step (4) gained medicinal liquid are merged, obtain decoction.
embodiment 2the Chinese medicine preparation for the treatment of chronic pyelonephritis, the primary raw material medicine getting following weight is prepared from: Medulla Junci 45g, Maifanitum 12g, Herba Plantaginis 25g, Radix Codonopsis 12g, Rhizoma Smilacis Glabrae 12g, Herba Cirsii 15g, Rhizoma Imperatae 40g, Herba Capsellae 25g, Herba Polygoni Avicularis 25g, Radix Glycyrrhizae uralensis 10g.
The preparation method of the Chinese medicine preparation powder for the treatment of chronic pyelonephritis is:
(1) each crude drug is removed impurity, pulverize respectively and grind to form fine powder, cross 160 mesh sieves;
(2) step (1) gained fine powder is dropped into mixing and blending machine fully to mix, sterile packaged, often wrap 6 grams.
model case one:zheng XX, female, 35 years old, December in 2012 first visit on the 22nd.Main suit: urgent micturition, dysurea about ten years repeatedly, increases the weight of 1 year.Medical history: Mrs's Zheng 5 years causes are suffered from cold and show trouble urgent micturition, dysurea, and disappear through curing performance, rear idol has outbreak, and attack times increased in nearly 1 year.Cause fatigue in four months, catch a cold and show frequent micturition, urgent micturition, dysurea, lower abdomen pendant pain, lumbago, beatting up element with cefalexin and Ao and cure and can control.Front upper disease bounce-back in two weeks, does not heal repeatedly.Existing the lumbago soreness of waist, sagging distention in the smaller abdomen cold type of pain, frequent micturition, urgent micturition, dysurea, the two lower limbs edema of trick, fear of cold is unable, white and slippery fur, deep and weak pulse.Albuminuria PRO+, urinary leukocyte 0-2/HP, midstream urine antibacterial culturing: bacterial population > 1 × 10 8bacterium number/L.Differential diagnosis in tcm: kidney yang deficiency, damp-heat in the urinary bladder.Western medicine diagnose: chronic pyelonephritis.Take the Chinese medicine preparation powder of the present embodiment gained treatment chronic pyelonephritis, every day twice, each 6g, boiled water is taken after mixing it with water.Take 5 days, the performance of urine urgency-frequency dysurea disappears, and lower abdomen pendant pain is not obvious, and lumbago alleviates, and trick and two lower limb still have Mild edema, thin white fur of tongue, deep-rolling pulse.Take 10 days, all transference cures, check routine urinalysis: albumen (-), leukocyte 0-1/HP, midstream urine antibacterial culturing is negative, recovery from illness.Follow up a case by regular visits to half a year not rebound.
embodiment 3the Chinese medicine preparation for the treatment of chronic pyelonephritis, the primary raw material medicine getting following weight is prepared from: Medulla Junci 28g, Maifanitum 7g, Herba Plantaginis 20g, Radix Codonopsis 8g, Rhizoma Smilacis Glabrae 7g, Herba Cirsii 8g, Rhizoma Imperatae 25g, Herba Capsellae 17g, Herba Polygoni Avicularis 16g, Radix Glycyrrhizae uralensis 7g.
The preparation method of the Chinese medicine preparation thick paste agent for the treatment of chronic pyelonephritis is:
(1) Rhizoma Smilacis Glabrae is first used vexed 2.5 hours of water, the consumption of water is 1/10 of Rhizoma Smilacis Glabrae weight, rear wine moistening 3 hours, and the consumption of wine is 1/7 of Rhizoma Smilacis Glabrae weight, dries;
(2) Maifanitum is smashed be placed in marmite, add the water of 2.5 times amount Maifanitum weight, first boil to boiling with big fire, turn little fire and decoct 2 hours afterwards, leach medicinal liquid;
(3) Herba Plantaginis is first installed with gauze bag, then join in above-mentioned marmite with step (1) gained Rhizoma Smilacis Glabrae and Radix Codonopsis, Herba Cirsii, Rhizoma Imperatae, Herba Polygoni Avicularis, Radix Glycyrrhizae uralensis, add the water of medical material gross weight added by 3.5 times amount, first boil to boiling with big fire, rear turn of little fire decocts 0.8 hour, leaches medicinal liquid;
(4) Medulla Junci and Herba Capsellae are joined in above-mentioned marmite, add the water of 2.8 times amount medical material gross weights, first boil to boiling with big fire, rear turn of little fire decocts 28 minutes, leaches medicinal liquid;
(5) step (2), step (3) and step (4) gained medicinal liquid are merged, decompression, is concentrated into the clear paste that relative density is 1.3, then adds adjuvant and mix well, and seals and get final product in dress aseptic bottle.
model case two:king XX, female, 40 years old.After patient suffers from acute nephritis spring in 2009, recurrent exerbation, obstinate.Recently see again the dizzy soreness of waist, frequency of micturition difficulty is prohibited, and reaches more than 20 every day, and dark coloured urine is muddy, and Mental fatigue is drowsiness, anorexia, and after tired, above-mentioned all diseases are aggravated all the more, finally cause weak and limp from head to foot, almost can not walk.Then to be admitted to hospital diagnosis and treatment.Urine examination at that time: color cloud, leukocyte (+++), erythrocyte (++), albumen is a little, and epithelial cell is a little, is diagnosed as chronic pyelonephritis.Take the Chinese medicine preparation thick paste agent of the present embodiment gained treatment chronic pyelonephritis, every day three times, each 15 grams, warm water takes.After taking 6 days, patient mental take a turn for the better, appetite increase, total urination time comparatively before subtract greatly, arteries and veins turns mitigation.Take 15 days, urine examination: leukocyte (-), erythrocyte (-), albumen (-), does not find epithelial cell, clinical asymptomatic.Follow up a case by regular visits to and do not recur.
embodiment 4the Chinese medicine preparation for the treatment of chronic pyelonephritis, the primary raw material medicine getting following weight is prepared from: Medulla Junci 40g, Maifanitum 10g, Herba Plantaginis 23g, Radix Codonopsis 11g, Rhizoma Smilacis Glabrae 10g, Herba Cirsii 12g, Rhizoma Imperatae 32g, Herba Capsellae 22g, Herba Polygoni Avicularis 21g, Radix Glycyrrhizae uralensis 9g.
The preparation method of the Chinese medicine preparation pill for the treatment of chronic pyelonephritis is:
(1) each crude drug is removed impurity, after drying, these medicines are mixed together and are ground into fine powder, cross 160 mesh sieves, mixing;
(2) joined by refined honey in step (1) gained fine powder, the weight of refined honey is 0.8 times of medicine gross weight, and making every ball weight is the small honey pill of 0.3g.
model case three:pungent XX, female, 45 years old.Frequent micturition, urgent micturition, dysurea 10 years repeatedly, intermittent blepharoedema 3 years, paroxysmal lumbago companion nocturia increases 1 year, increases the weight of to be admitted to hospital for 10 days.Physical examination: blood pressure 158/106mmHg, two kidney percussion pain.Lab testing: urinary leukocyte (++), albumen (++), urine density 1.010, urine cultivates escherichia coli (Escherichia coli) growth, serum creatinine 470 μm of ol/L.Ultrasound diagnosis is shown: two kidney is asymmetric to be reduced, and distortion obviously.Be diagnosed as chronic pyelonephritis.Once with antibiotic and antimicrobial drug treatment, the state of an illness failed to control.Take the Chinese medicine preparation pill of the present embodiment gained treatment chronic pyelonephritis, every day three times, each 12, warm water takes.Take 3 days, blood pressure recovers normal, and symptom alleviates.Take 15 days, each index of urine examination recovers normal, and ultrasound diagnosis display is normal, recovery from illness.Follow up a case by regular visits to so far, have no recurrence.
embodiment 5the Chinese medicine preparation for the treatment of chronic pyelonephritis, the primary raw material medicine getting following weight is prepared from: Medulla Junci 34g, Maifanitum 9g, Herba Plantaginis 22g, Radix Codonopsis 10g, Rhizoma Smilacis Glabrae 8g, Herba Cirsii 11g, Rhizoma Imperatae 29g, Herba Capsellae 20g, Herba Polygoni Avicularis 18g, Radix Glycyrrhizae uralensis 8g.
The preparation method of the Chinese medicine preparation decoction for the treatment of chronic pyelonephritis is:
(1) Rhizoma Smilacis Glabrae is first used vexed 2.5 hours of water, the consumption of water is 1/10 of Rhizoma Smilacis Glabrae weight, vexed 3 hours of rear wine, and the consumption of wine is 1/7 of Rhizoma Smilacis Glabrae weight, dries;
(2) Maifanitum is smashed be placed in marmite, add the water of 2.5 times amount Maifanitum weight, first boil to boiling with big fire, turn little fire and decoct 2 hours afterwards, leach medicinal liquid;
(3) Herba Plantaginis is first installed with gauze bag, then join in above-mentioned marmite with step (1) gained Rhizoma Smilacis Glabrae and Radix Codonopsis, Herba Cirsii, Rhizoma Imperatae, Herba Polygoni Avicularis, Radix Glycyrrhizae uralensis, add the water of medical material gross weight added by 3.5 times amount, first boil to boiling with big fire, rear turn of little fire decocts 0.8 hour, leaches medicinal liquid;
(4) Medulla Junci and Herba Capsellae are joined in above-mentioned marmite, add the water of 2.8 times amount medical material gross weights, first boil to boiling with big fire, rear turn of little fire decocts 28 minutes, leaches medicinal liquid;
(5) step (2), step (3) and step (4) gained medicinal liquid are merged, obtain decoction.
test example 1the clinical practice of Chinese medicine preparation decoction of embodiment 5 gained treatment chronic pyelonephritis: in August, 2009 in December ,-2011, screen 288 routine chronic pyelonephritis patients in 8 hospitals, be divided into two groups at random, treatment group and matched group.Treatment group 144 example, male 58 example, women 86 example, age 30-58 year, average 42.3 years old, course of disease 1.5-13, average course of disease 7.2 years.Matched group 144 example, male 57 example, women 87 example, age 32-59 year, average 43.4 years old, course of disease 1.5-13, average course of disease 7.5 years.Between two groups of patients, the aspect such as sex, age, course of disease compares, and no significant difference (P > 0.05), has comparability.Treatment group takes embodiment 5 products obtained therefrom, and instructions of taking is: take every day twice (warm), each 300mL.Matched group uses the conventional medication (as cephalosporin, carbenicillin, amoxicillin, levofloxacin hydrochloride and sodium chloride injection etc.) of other treatment chronic pyelonephritis.
Diagnostic criteria
The chronic pyelonephritis diagnostic criteria that the diagnostic criteria of chronic pyelonephritis is passed through with reference to the academic conference of Second China National nephropathy and " internal medicine " (5 editions) chronic pyelonephritis diagnostic criteria: 1. regular CCMS bacteria quantified cultivates clump count>=10 5/ mL; Clean centrifugal midstream urine sediment leukocyte>=10/HP; 2. urinary tract infection medical history > 6 months, in frequent outbreak 6 months>=2 times or 1 year in>=3 times; 3. X-ray intravenous urography is shown: renal pelvis renal calices distortion constriction; 4. soreness of waist pain, fatigue and weakness, dripping urination, sagging distention in the smaller abdomen, meets labor and originator.Meet and 1. 2. 4. or 1. 3. 4. get final product diagnosing chronic pyelonephritis.
Efficacy assessment standard
Criterion of therapeutical effect according to " new Chinese medicine guideline of clinical investigations " is drafted.Clinical cure: clinical symptoms, sign disappear, routine urianlysis twice is all normal, and urine bacterium is negative, and is feminine gender in 2-6 week check urine bacterium; Effective: clinical symptoms, sign disappear or substantially disappear, routine urinalysis is normal or close to normal, urine bacterium is negative; Effective: clinical symptoms, sign alleviate, and routine urinalysis significantly improves, urine bacterium is cultivated has the positive once in a while; Invalid: symptom and urine examination improve not obvious, the quantitative check of urine bacterium is still positive, or 2-6 week check urine bacterium is positive.Total effectively comprising cures and effective.Treat the effect after 14 days as shown in table 1.
Table 1: take embodiment 5 product chronic pyelonephritis patient treatment outcome
Effect: treatment group recovery from illness 103 example, total effective rate is 97.92%, and matched group recovery from illness 50 example, total effective rate is 64.58%, and treatment group is obviously better than matched group.Experiment shows, compared with using the conventional medication of other treatment chronic pyelonephritis, uses the cure rate of the Chinese medicine preparation of embodiment 5 gained treatment chronic pyelonephritis significantly to promote, and and inefficiency significantly reduce, curative effect is greatly improved.
The present invention selects Medulla Junci, Maifanitum, Herba Plantaginis etc. to carry out compatibility, produces synergism after making these drug regimens, for treatment chronic pyelonephritis Be very effective.Medulla Junci clearing away heart-fire in side, diuresis.Maifanitum removing toxic substances and promoting granulation, damp eliminating spleen invigorating.Herba Plantaginis clearing away heat and promoting diuresis, eliminates the phlegm, removing heat from blood, removing toxic substances.Radix Codonopsis invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.Rhizoma Smilacis Glabrae detoxifies, dehumidifying, sharp joint.Herba Cirsii cooling blood for hemostasis, removing toxic substances and promoting subsidence of swelling.Rhizoma Imperatae cooling blood for hemostasis, clearing away heat and promoting diuresis.The cool liver hemostasis of Herba Capsellae, suppressing the hyperactive liver improving eyesight, clearing away heat-damp and promoting diuresis.Herba Polygoni Avicularis inducing diuresis for treating stranguria syndrome, parasite killing, antipruritic.Radix Glycyrrhizae uralensis eliminating fire and detoxication, inducing diuresis for treating stranguria syndrome.All medicines share, and have clearing away heat-damp and promoting diuresis, inducing diuresis for treating stranguria syndrome, removing toxic substances and promoting subsidence of swelling, invigorating the spleen and replenishing QI, the effects such as spleen invigorating lung benefiting.The present invention has good effect, short treating period, advantage that cure rate is high to treatment chronic pyelonephritis, and has no side effect.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. treat the Chinese medicine preparation of chronic pyelonephritis, it is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Medulla Junci 25-45, Maifanitum 5-12, Herba Plantaginis 18-25, Radix Codonopsis 6-12, Rhizoma Smilacis Glabrae 6-12, Herba Cirsii 6-15, Rhizoma Imperatae 20-40, Herba Capsellae 15-25 ， Herba Polygoni Avicularis 15-25, Radix Glycyrrhizae uralensis 6-10.
2. the Chinese medicine preparation for the treatment of chronic pyelonephritis according to claim 1, it is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Medulla Junci 28-40, Maifanitum 7-10, Herba Plantaginis 20-23, Radix Codonopsis 8-11, Rhizoma Smilacis Glabrae 7-10, Herba Cirsii 8-12, Rhizoma Imperatae 25-32, Herba Capsellae 17-22 ， Herba Polygoni Avicularis 16-21, Radix Glycyrrhizae uralensis 7-9.
3. the Chinese medicine preparation for the treatment of chronic pyelonephritis according to claim 1, is characterized in that, takes off the primary raw material medicine stating weight proportion and is prepared from: Medulla Junci 34, Maifanitum 9, Herba Plantaginis 22, Radix Codonopsis 10, Rhizoma Smilacis Glabrae 8, Herba Cirsii 11, Rhizoma Imperatae 29, Herba Capsellae 20 ， Herba Polygoni Avicularis 18, Radix Glycyrrhizae uralensis 8.
4. the Chinese medicine preparation of the treatment chronic pyelonephritis as described in as arbitrary in claim 1-3, is characterized in that, the Chinese medicine preparation of this treatment chronic pyelonephritis is made pharmaceutically acceptable decoction, powder, thick paste agent and pill.
5. the preparation method of the Chinese medicine preparation for the treatment of chronic pyelonephritis as claimed in claim 4, it is characterized in that, the preparation method of described decoction is:
(1) Rhizoma Smilacis Glabrae is first used the vexed 1-4 of water hour (preferably vexed 2.5 hours), the consumption of water is the consumption of the 1/25-1/8(preferred water of Rhizoma Smilacis Glabrae weight is 1/10 of Rhizoma Smilacis Glabrae weight), after use the vexed 2-5 of wine hour (preferably vexed 3 hours), the consumption of wine is the consumption of the preferred wine of 1/20-1/8(of Rhizoma Smilacis Glabrae weight is 1/7 of Rhizoma Smilacis Glabrae weight), dry;
(2) Maifanitum is smashed be placed in marmite, add the water (preferably adding the water of 2.5 times amount Maifanitum weight) of 2-5 times amount Maifanitum weight, first boil to boiling with big fire, turn little fire and decoct 1-3 hour (preferably decocting 2 hours) afterwards, leach medicinal liquid;
(3) Herba Plantaginis is first installed with gauze bag, then join in above-mentioned marmite with step (1) gained Rhizoma Smilacis Glabrae and Radix Codonopsis, Herba Cirsii, Rhizoma Imperatae, Herba Polygoni Avicularis, Radix Glycyrrhizae uralensis, add the water (preferably adding the water of medical material gross weight added by 3.5 times amount) of medical material gross weight added by 2.5-6 times amount, first boil to boiling with big fire, rear turn of little fire decocts 0.5-1.5 hour (preferably decocting 0.8 hour), leaches medicinal liquid;
(4) Medulla Junci and Herba Capsellae are joined in above-mentioned marmite, add the water (preferably adding the water of 2.8 times amount medical material gross weights) of 2-5 times amount medical material gross weight, first boil to boiling with big fire, rear turn of little fire decocts 10-40 minute (preferably decocting 28 minutes), leaches medicinal liquid;
(5) step (2), step (3) and step (4) gained medicinal liquid are merged, obtain decoction.
6. the preparation method of the Chinese medicine preparation for the treatment of chronic pyelonephritis as claimed in claim 4, it is characterized in that, the preparation method of described powder is:
(1) each crude drug is removed impurity, pulverize respectively and grind to form fine powder, cross 120-180 mesh sieve (preferred mistake 160 mesh sieve);
(2) step (1) gained fine powder is dropped into mixing and blending machine fully to mix, sterile packaged, often wrap 6 grams.
7. the preparation method of the Chinese medicine preparation for the treatment of chronic pyelonephritis as claimed in claim 4, it is characterized in that, the preparation method of described thick paste agent is:
(1) Rhizoma Smilacis Glabrae is first used water moistening 1-4 hour (preferably vexed 2.5 hours), the consumption of water is the consumption of the 1/25-1/8(preferred water of Rhizoma Smilacis Glabrae weight is 1/10 of Rhizoma Smilacis Glabrae weight), after use the vexed 2-5 of wine hour (preferably vexed 3 hours), the consumption of wine is the consumption of the preferred wine of 1/20-1/8(of Rhizoma Smilacis Glabrae weight is 1/7 of Rhizoma Smilacis Glabrae weight), dry;
(2) Maifanitum is smashed be placed in marmite, add the water (preferably adding the water of 2.5 times amount Maifanitum weight) of 2-5 times amount Maifanitum weight, first boil to boiling with big fire, turn little fire and decoct 1-3 hour (preferably decocting 2 hours) afterwards, leach medicinal liquid;
(3) Herba Plantaginis is first installed with gauze bag, then join in above-mentioned marmite with step (1) gained Rhizoma Smilacis Glabrae and Radix Codonopsis, Herba Cirsii, Rhizoma Imperatae, Herba Polygoni Avicularis, Radix Glycyrrhizae uralensis, add the water (preferably adding the water of medical material gross weight added by 3.5 times amount) of medical material gross weight added by 2.5-6 times amount, first boil to boiling with big fire, rear turn of little fire decocts 0.5-1.5 hour (preferably decocting 0.8 hour), leaches medicinal liquid;
(4) Medulla Junci and Herba Capsellae are joined in above-mentioned marmite, add the water (preferably adding the water of 2.8 times amount medical material gross weights) of 2-5 times amount medical material gross weight, first boil to boiling with big fire, rear turn of little fire decocts 10-40 minute (preferably decocting 28 minutes), leaches medicinal liquid;
(5) step (2), step (3) and step (4) gained medicinal liquid are merged, decompression, being concentrated into relative density is that to be preferably concentrated into relative density be 1.3 to 1.0-1.4() clear paste, then add adjuvant and mix well, seal and get final product in dress aseptic bottle.
8. the preparation method of the Chinese medicine preparation for the treatment of chronic pyelonephritis as claimed in claim 4, it is characterized in that, the preparation method of described pill is:
(1) each crude drug is removed impurity, after drying, these medicines be mixed together and be ground into fine powder, sieving, mixing;
(2) joined by refined honey in step (1) gained fine powder, the weight of refined honey is 1/2-1.2 times (weight of preferred refined honey is 0.8 times of medicine gross weight) of medicine gross weight, makes small honey pill.
9. the preparation method of the Chinese medicine preparation pill for the treatment of chronic pyelonephritis as claimed in claim 8, is characterized in that, with 140-220 object sieve (preferably using 160 object sieve).
10. the preparation method of the Chinese medicine preparation pill for the treatment of chronic pyelonephritis as claimed in claim 8, is characterized in that, the weight of the every ball of the small honey pill made is the weight of the preferred every ball of 0.1-0.4g(is 0.3g).
CN201410540263.1A 2014-10-14 2014-10-14 Chinese herbal preparation for treating chronic nephropyelitis and preparation method thereof Pending CN104225344A (en)

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CN105687548A (en) * 2016-04-13 2016-06-22 刘海强 Chronic nephritis treating medicine

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