CN1778360A - Burn and scald medicine - Google Patents
Burn and scald medicine Download PDFInfo
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- CN1778360A CN1778360A CN 200410036516 CN200410036516A CN1778360A CN 1778360 A CN1778360 A CN 1778360A CN 200410036516 CN200410036516 CN 200410036516 CN 200410036516 A CN200410036516 A CN 200410036516A CN 1778360 A CN1778360 A CN 1778360A
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Abstract
A Chinese medicine in the form of liquid for treating burn and scald by exterior application is prepared from rhubarb, phellodendron bark, giant knotweed rhizome, Folium ilicis chinensis and sanguisorba root through immersing them in the solution of alcohol. Its advantages are quickly taken its high curative effect and no toxic by-effect.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of burn, scalding, relating in particular to the vegetable Chinese herbal medicine is the burn-scald medicine that raw material is made.
Background technology
Burn and scald are common skin wound surface diseases in the daily life, bring in various degree misery to wounded body, and be serious even can cause death.
Infection is distinct issues in treatment burn, the scald.According to the analysis that as burn case of army medical university of domestic a few institute 9329 examples, infect ranking first in the burn cause of death, account for 51.8%.Infect as fail control, consequently visceral complications takes place in succession, finally causes septic shock, multiple organ dysfunction syndrome and death.Doctor trained in Western medicine surgical intervention burn and scald carries out also being equipped with the Surgery Treatment oral antibiotic class Drug therapy to prevent traumatic infection except adopting occlusive dressing, in addition wound surface is also applied such as externally used antimicrobial medicines such as 1% silver sulfadiazine cream, povidone iodine.These externally used antimicrobial medicines are bacteria growing inhibiting to a certain extent, and tissue of burn is separated with health tissues through liquefying by the coagulation necrosis of beginning and needs 2-3 week, in this course, the threat of invasive infection is arranged all at any time; On the other hand because heavy dose of antibiotic that uses, except to the toxic and side effects of Liver and kidney greatly, also often cause dysbacteriosis in the body, bring out superinfection.In addition, the employing occlusive dressing is unfavorable for the heat radiation of wound surface on the one hand, and is favourable to fungi growth, and is not easy to observe the wound surface variation, can't adjust therapeutic scheme immediately; On the other hand, also need duty to change dressings at the position that wound surface has infected, remove purulent secretion, whenever change a medicine patient and just suffer once misery, and the course of treatment is long, the expense height easily stays cicatrix after the healing.To the patient of some III degree burn and scald, also need isolate at aseptic isolation ward, the processing that then undergos surgery is as skin-grafting, amputation etc.
Surgery of Chinese medicine treatment burn and scald adopts the Chinese medicine ointment to treat mostly, has pain relieving, anti-infective characteristics, curative effect is more remarkable, but existing Traditional Chinese Medicine for external application has following shortcoming: (1) ingredient complexity, and required raw material is many, course of processing complexity, cost height are unfavorable for suitability for industrialized production; (2) some raw material is difficult to obtain, thereby influence is produced; Also be to adopt occlusive dressing when (3) adopting these plaster treatments, must often change dressings, bring misery to patient, and easily deepen wound surface, easily stay cicatrix after the healing.
Summary of the invention
The burn-scald medicine that the present invention aims to provide that a kind of anti-infection property is strong, short treating period, the dark II degree of establishment are cured the back preventing from scar.
The present invention is based on such design concept: according to Chinese medicine pharmacy and Chinese traditional treatment theory, selecting Radix Et Rhizoma Rhei, Cortex Phellodendri, Rhizoma Polygoni Cuspidati, Ilex purpurea Hassk.[I.chinensis Sims, Radix Sanguisorbae for use is the primary raw material medicine, and Flos Lonicerae, Fructus Forsythiae, Borneolum Syntheticum are the auxiliary material medicine.
Radix Et Rhizoma Rhei: bitter in the mouth, cold in nature, nontoxic, the effect of eliminating fire and detoxication is arranged, and its Radix Et Rhizoma Rhei anthraquinone chemical compound that contains has very strong antibacterial action, to suppressing staphylococcus aureus, bacillus pyocyaneus, escherichia coli specially good effect is arranged.
Cortex Phellodendri: bitter in the mouth, cold in nature, nontoxic, the effect of heat clearing and damp drying, eliminating fire and detoxication, anti-inflammatory analgetic is arranged.But not only oral administration but also external have significant inhibitory effect to staphylococcus aureus.
Rhizoma Polygoni Cuspidati: bitter in the mouth, cold nature, nontoxic, have expelling wind and removing dampness, broken become silted up stimulate the menstrual flow, the effect of heat-clearing and toxic substances removing.Can control eczema, herpes zoster, furuncle and phyma, trauma infection contamination, Hemolytic streptococcus, staphylococcus aureus are had significant inhibitory effect.
Ilex purpurea Hassk.[I.chinensis Sims: bitter in the mouth, puckery, cold in nature, nontoxic, have the effect of cooling blood for hemostasis, heat-clearing and toxic substances removing.And have broad-spectrum antibacterial action, staphylococcus aureus, bacillus pyocyaneus, escherichia coli are all had inhibitory action, be used for the treatment of the protectiveness crust film that burn and scald can very fast formation one deck be complete on wound surface, can prevent dehydration and bacteria attack.
Radix Sanguisorbae: bitter in the mouth, acid, cold nature, nontoxic, have the effect that anti-inflammatory analgetic, cooling blood for hemostasis, pathogenic fire purging are held back skin ulcer, antibacterial and detoxicating.Fat water is reduced, and pain relief, healing are quickened, and staphylococcus aureus, bacillus pyocyaneus etc. is had very strong antibacterial action.
Flos Lonicerae: sweet in the mouth, cold in nature, nontoxic, have the effect of heat-clearing and toxic substances removing, removing heat from blood.Quite strong for red and swollen heat pain, sore and toxic effect, and staphylococcus aureus, Hemolytic streptococcus had inhibitory action, find that after deliberation its soak is stronger than the bacteriostasis of decoct.
Fructus Forsythiae: bitter in the mouth, cold nature, nontoxic, have the effect of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Its forsythol that contains also has inhibitory action to the antibacterial efficacy maximum of staphylococcus aureus to other pathogenic bacteria.
Borneolum Syntheticum: bitter in the mouth, cool in nature, nontoxic, detumescence, pain relieving are arranged, the effect of the stagnated fire of loosing.
Effective ingredient in the fine dissolving Chinese medicine medical material of ethanol energy, on empyrosis wound surface, use the medicament that contains ethanol not only can play disinfective action, and can reduce the temperature of empyrosis wound surface, avoid the empyrosis wound surface persistent fever and cause heating power to continue damage, intensification wound surface, healing speed is accelerated.
The technical solution adopted in the present invention is: a kind of burn-scald medicine, it is characterized in that: be to be the primary raw material medicine with Radix Et Rhizoma Rhei, Cortex Phellodendri, Rhizoma Polygoni Cuspidati, Ilex purpurea Hassk.[I.chinensis Sims, Radix Sanguisorbae, the liquid preparation that soaks in alcoholic solution and make, the weight proportion of primary raw material medicine is in every 1ml ethanol: Radix Et Rhizoma Rhei 0.04-0.07g, Cortex Phellodendri 0.05-0.07g, Rhizoma Polygoni Cuspidati 0.05-0.06g, Ilex purpurea Hassk.[I.chinensis Sims 0.03-0.05g, Radix Sanguisorbae 0.08-0.10g.
Also comprise Flos Lonicerae, Fructus Forsythiae in the described crude drug, the weight proportion of each component is in every 1ml ethanol: Radix Et Rhizoma Rhei 0.04-0.05g, Cortex Phellodendri 0.05-0.06g, Rhizoma Polygoni Cuspidati 0.05-0.06g, Ilex purpurea Hassk.[I.chinensis Sims 0.03-0.04g, Radix Sanguisorbae 0.08-0.09g, Flos Lonicerae 0.015-0.025g, Fructus Forsythiae 0.015-0.025g.
Also comprise Flos Lonicerae, Fructus Forsythiae, Borneolum Syntheticum in the described crude drug, the weight proportion of each component is in every 1ml ethanol: Radix Et Rhizoma Rhei 0.04-0.05g, Cortex Phellodendri 0.05-0.06g, Rhizoma Polygoni Cuspidati 0.05-0.06g, Ilex purpurea Hassk.[I.chinensis Sims 0.03-0.04g, Radix Sanguisorbae 0.08-0.09g, Flos Lonicerae 0.015-0.02g, Fructus Forsythiae 0.015-0.02g, Borneolum Syntheticum 0.01-0.02g.
Ethanol content is 60～70% in the described alcoholic solution.
Prescription of the present invention is reasonable, can give full play to its synergism behind the selected Chinese herbal medicine compatibility, and with ethanol as solvent, be more conducive to sterilization, sterilization and the healing of wound surface.Prove that through inventor's repetition test adopt burn-scald medicine treatment burn and scald of the present invention, can produce following beyond thought effect: one, analgesic effect is fairly obvious, but generally pain relieving in a minute after medication.Two, anti-infection property is strong, need not use antibiotics after the medicine-feeding, need not set up sterilizing room, even wound surface infection suppurates also can diminish inflammation without antibiotic therapy after using this medicine, makes wound healing.Three, can adopt exposure method treatment burn and scald, after being about to medicament and being sprayed on the wound surface, wound surface does not need to wrap up but and can not infect, and need not clean wound surface during spray next time medicine, gets final product but directly spray medicine on the wound surface again, and is easy to operate.
Adopt exposure method, the transudate on the wound surface can evaporate the formation dry crusts soon, can stop the antibacterial intrusion; In addition, the temperature of wound surface can be hanged down 2～3 ℃ than the temperature of health normal structure, is unfavorable for the breeding of antibacterial, and is convenient to observe the wound surface variation, grasps the initiative of treatment.To deep burn, wound surface exposes the integrity that helps keeping eschar, and treatment can act out one's plan.Four, short treating period is suitable for shallow degree of large tracts of land and deep burn.Reach 85% patient to newly establishing dark II degree scalding area, spray behind this medicine and can fully recover no cicatrix in about 20 days.The III degree is scalded single area 1% with interior patient, spray behind this medicine and can fully recover in 1 month, need not make skin graft the essentially no cicatrix in recovery from illness back.Five, the present invention fills a prescription simply, and the medicine source is abundant, concocts simply, and production cost is low, is suitable for industrialized great production.
The inventor is from year November in June, 1994-2004, with all kinds of burn and scald 450 examples of respectively spending of pharmaceutical treatment of the present invention, the burn and scald degree from the I degree to the III degree, area from 1% to 75%, the age, cure rate reached 100% from 3 months to 76 years old, effective percentage reaches 100%.This shows that the present invention is evident in efficacy, have no side effect to have the good potentiality of applying.
The specific embodiment
Embodiment 1: with Radix Et Rhizoma Rhei 0.04g, Cortex Phellodendri 0.06g, Rhizoma Polygoni Cuspidati 0.05g, Ilex purpurea Hassk.[I.chinensis Sims 0.04g, Radix Sanguisorbae 0.10g clean mix after, dry, then insert ethanol content and be in 70% the alcoholic solution, soaks after 40～50 days, filtration makes liquid preparation and can use.
Embodiment 2:.After Radix Et Rhizoma Rhei 0.05g, Cortex Phellodendri 0.05g, Rhizoma Polygoni Cuspidati 0.06g, Ilex purpurea Hassk.[I.chinensis Sims 0.03g, Radix Sanguisorbae 0.08g, Flos Lonicerae 0.02g, the clean mixing of Fructus Forsythiae 0.015g, dry, then insert ethanol content and be in 60% the alcoholic solution, soak after 50～60 days, filter and make liquid preparation and can use.
Embodiment 3: after Radix Et Rhizoma Rhei 0.04g, Cortex Phellodendri 0.05g, Rhizoma Polygoni Cuspidati 0.06g, Ilex purpurea Hassk.[I.chinensis Sims 0.04g, Radix Sanguisorbae 0.09g, Flos Lonicerae 0.015g, Fructus Forsythiae 0.02g, Borneolum Syntheticum 0.015g are cleaned mixing, dry, then insert ethanol content and be in 65% the alcoholic solution, soak after 50～55 days, filtration makes liquid preparation and can use.
Application example of the present invention is as follows: get dissimilar burn and scald.
Application test example 1: petrol burn.
Sieve XX, man, 29 years old.By petrol burn, burn wound is distributed in neck surface, shirtfront, both hands, two forearm, two buttocks, both thighs, biped etc. and locates accidentally.Wound pain is felt xerostomia, pharyngalgia unbearably simultaneously, and neck surface, both hands and two forearm swelling are obvious, the wound surface heavy contamination, and slight imbedibility burn is arranged, fear of cold, but do not have heating.Through being diagnosed as severe burn, the burn gross area reaches 52%.Clean wound surface, the place to go dead bark, blot the transudate of wound surface with antiseptic gauze after, adopt exposure method, medicament of the present invention is sprayed on the wound surface, spray with wound surface moistening degree of being, sprayed once in per six hours.One minute patient is emotionally stable behind the spray medicine, and is painless, the imitation leather recovery from illness that comes off after 22 days.
Application test example 2: boiled water is scalded.
Surplus XX, man, 5 years old.By the boiled pot scald of washing, scald wound is distributed in cervical region, right upper arm, shirtfront etc. and locates accidentally, and the scald face works the bleb skin that differs in size, thick blister.Scald for the II degree through making a definite diagnosis cervical region, area 3%, anterior part of chest are that depth II degree is scalded, area 10%, and right upper arm is that dark II degree is scalded, area 4% is scalded the gross area and is reached 17%.Clean wound surface, the place to go dead bark, blot the transudate of wound surface with antiseptic gauze after, adopt exposure method, medicament of the present invention is sprayed on the wound surface, spray with wound surface moistening degree of being, sprayed once in per six hours.One minute patient is emotionally stable behind the spray medicine, and is painless, recovery from illness after 20 days.
Application test example 3: rusting is hindered.
Surplus XX, man, 30 years old.The flame burn of being lighted by Adeps Sus domestica accidentally burns wound surface and is distributed in neck surface, preceding trunk, right forearm, right upper arm etc. and locates.Wound pain unbearably, skin wound has the blister that differs in size, avulsion place wound surface has and oozes out golden yellow liquid.Through making a definite diagnosis neck surface, right upper arm is II degree burn, area 9%, and preceding trunk, right forearm are deep ii degree burn, area 16%, the burn gross area reaches 25%.Clean wound surface, the place to go dead bark, blot the transudate of wound surface with antiseptic gauze after, adopt exposure method, medicament of the present invention is sprayed on the wound surface, spray with wound surface moistening degree of being, sprayed once in per six hours.One minute patient is emotionally stable behind the spray medicine, and is painless, recovery from illness after 18 days.
Application test example 4: pig feed is scalded.
Yellow XX, man, 5 years old.Scalded by pig feed accidentally, scald wound is distributed in right hand half sole, trunk front and rear part, two buttocks, both thighs, both legs, biped etc. and locates.Scald through making a definite diagnosis the dark II degree in trunk front portion, both thighs, area 33%, right hand half sole, trunk rear portion, two buttocks, both legs, biped II degree are scalded, and area 29% is scalded the gross area and is reached 62%.Clean wound surface, the place to go dead bark, blot the transudate of wound surface with antiseptic gauze after, adopt exposure method, medicament of the present invention is sprayed on the wound surface, spray with wound surface moistening degree of being, sprayed once in per six hours.One minute patient is emotionally stable behind the spray medicine, and is painless, recovery from illness after 17 days.
Application test example 5: molten iron burn.
Lee XX, man, 42 years old.By the molten iron of iron-smelting furnace burn, burn wound is distributed in neck surface, front and back trunk, two forearm, two upper arm, two buttocks, biped, both legs, both thighs etc. and locates accidentally.Sample pain is burnt by burn wound, works the vesicle that differs in size on the wound surface, and yellow liquid is oozed out in the avulsion of part bleb skin, and patient's cyanotic lips is thirsty, fear of cold.Burn through making a definite diagnosis neck surface II degree, area 9%, front and back trunk, two forearm, two upper arm, two buttocks, biped, both thighs deep ii degree burn, dark II degree of both legs and III degree burn, the burn gross area reaches 70%.Press earlier the conventional one-level nursing of burns unit, transfusion, shock, recovery etc., clear up wound surface then, place to go bleb skin adopts exposure method, and medicament of the present invention is sprayed on the wound surface, sprinkling is with wound surface moistening degree of being, sprayed once in per 4～6 hours, most of wound surface was fully recovered after 28 days, and the wound surface of other III degree burn was fully recovered after 50 days.
Claims (4)
1, a kind of burn-scald medicine, it is characterized in that: be to be the primary raw material medicine with Radix Et Rhizoma Rhei, Cortex Phellodendri, Rhizoma Polygoni Cuspidati, Ilex purpurea Hassk.[I.chinensis Sims, Radix Sanguisorbae, the liquid preparation that soaks in alcoholic solution and make, the weight proportion of primary raw material medicine is in every 1ml ethanol: Radix Et Rhizoma Rhei 0.04-0.07g, Cortex Phellodendri 0.05-0.07g, Rhizoma Polygoni Cuspidati 0.05-0.06g, Ilex purpurea Hassk.[I.chinensis Sims 0.03-0.05g, Radix Sanguisorbae 0.08-0.10g.
2, burn-scald medicine according to claim 1, it is characterized in that: also comprise Flos Lonicerae, Fructus Forsythiae in the described crude drug, the weight proportion of each component is in every 1ml ethanol: Radix Et Rhizoma Rhei 0.04-0.05g, Cortex Phellodendri 0.05-0.06g, Rhizoma Polygoni Cuspidati 0.05-0.06g, Ilex purpurea Hassk.[I.chinensis Sims 0.03-0.04g, Radix Sanguisorbae 0.08-0.09g, Flos Lonicerae 0.015-0.025g, Fructus Forsythiae 0.015-0.025g.
3, burn-scald medicine according to claim 1, it is characterized in that: also comprise Flos Lonicerae, Fructus Forsythiae, Borneolum Syntheticum in the described crude drug, the weight proportion of each component is in every 1ml ethanol: Radix Et Rhizoma Rhei 0.04-0.05g, Cortex Phellodendri 0.05-0.06g, Rhizoma Polygoni Cuspidati 0.05-0.06g, Ilex purpurea Hassk.[I.chinensis Sims 0.03-0.04g, Radix Sanguisorbae 0.08-0.09g, Flos Lonicerae 0.015-0.02g, Fructus Forsythiae 0.015-0.02g, Borneolum Syntheticum 0.01-0.02g.
4, according to claim 1 or 2 or 3 described burn-scald medicines, it is characterized in that: ethanol content is 60～70% in the described alcoholic solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100365168A CN100427118C (en) | 2004-11-27 | 2004-11-27 | Burn and scald medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100365168A CN100427118C (en) | 2004-11-27 | 2004-11-27 | Burn and scald medicine |
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| Publication Number | Publication Date |
|---|---|
| CN1778360A true CN1778360A (en) | 2006-05-31 |
| CN100427118C CN100427118C (en) | 2008-10-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100365168A Expired - Fee Related CN100427118C (en) | 2004-11-27 | 2004-11-27 | Burn and scald medicine |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106539952A (en) * | 2016-11-21 | 2017-03-29 | 卢梦雄 | The Chinese medicine preparation for the treatment of burn |
| CN109200159A (en) * | 2018-10-30 | 2019-01-15 | 王心海 | A kind of ointment for burns and scalds and preparation method thereof |
| CN109481556A (en) * | 2018-12-19 | 2019-03-19 | 河南医学高等专科学校 | For treating medicament of burn and scald and preparation method thereof in a kind of clinical care |
| CN111991476A (en) * | 2019-07-25 | 2020-11-27 | 王晓兵 | A Chinese medicinal ointment for treating burn, and its preparation method |
| CN113425792A (en) * | 2021-08-13 | 2021-09-24 | 北京良方科技有限公司 | Traditional Chinese medicine external preparation for treating scalds and burns and preparation method and application thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1052420C (en) * | 1996-12-06 | 2000-05-17 | 董庭君 | Chinese medicine for curing burn and traumatic wound and its production method |
| CN1205961C (en) * | 2002-08-20 | 2005-06-15 | 王忠发 | Ointment for external application for curing scald and burn |
| CN1283290C (en) * | 2002-11-05 | 2006-11-08 | 潘福宽 | External burn cream |
-
2004
- 2004-11-27 CN CNB2004100365168A patent/CN100427118C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106539952A (en) * | 2016-11-21 | 2017-03-29 | 卢梦雄 | The Chinese medicine preparation for the treatment of burn |
| CN109200159A (en) * | 2018-10-30 | 2019-01-15 | 王心海 | A kind of ointment for burns and scalds and preparation method thereof |
| CN109481556A (en) * | 2018-12-19 | 2019-03-19 | 河南医学高等专科学校 | For treating medicament of burn and scald and preparation method thereof in a kind of clinical care |
| CN111991476A (en) * | 2019-07-25 | 2020-11-27 | 王晓兵 | A Chinese medicinal ointment for treating burn, and its preparation method |
| CN113425792A (en) * | 2021-08-13 | 2021-09-24 | 北京良方科技有限公司 | Traditional Chinese medicine external preparation for treating scalds and burns and preparation method and application thereof |
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| Publication number | Publication date |
|---|---|
| CN100427118C (en) | 2008-10-22 |
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