CN1233350C - Medication formulation for burn and scald - Google Patents

Abstract

The present invention relates to coated Chinese medicine ointment, particularly to a medicine preparation for treating burns and scalds, which is prepared from sanguisorba roots, propolis and sesame oil according to the compounding ratio of a recipe. By clinical certification, the coated Chinese medicine ointment has the advantages of rapid curative effect, hemostasis, pain alleviation, sterilization, inflammation elimination, effective prevention and control of wound surface infection and cross infection, less pain of patients and low cost and has no toxic or side effect, no requirement of skin graft and no scar after cure. Meanwhile, the dosage of antibiotics, and a toxic or side effect generated by the large dosage of antibiotics can be obviously reduced. Thus, medical expenses are obvious decreased, and hospitalization days are shortened. The coated Chinese medicine ointment is preferred external applied medicine for treating burns and scalds of various burns and scalds.

Description

Be used for the treatment of the pharmaceutical preparation of burn and scald

Technical field

The present invention relates to a kind of coating Chinese medicinal ointment, especially for the pharmaceutical preparation of treatment burn and scald.It is the first-selected medicine for external use of each rank burn and scald of treatment.

Background technology

By the caused tissue injury of heating power general designation burn, as flame, hydrothermal solution, vapours and thermometal or the like.Traumatic condition judges that the most basic requirement is the burn surface area and the degree of depth.Clinical in the past normally according to be slightly or in, the different situations of severe burn dispose respectively, and in, the severe burn person is except recording blood pressure, pulse, breathing, and notes having or not respiratory tract burn and other associated injuries; Set up the venous transfusion passage immediately, begin transfusion; Indwelling catheter begins debridement, estimation burn surface area, the degree of depth after per hour observing urine amount, proportion, pH value and noting having or not conventional emergency measure such as hemoglobinuria.Should note having or not the compressing of III ° of ring-type eschar especially, it can influence blood circulation at the limbs position, and metastomium can influence breathing, should cut the eschar decompression.Infection is distinct issues in the treatment burn.According to the analysis that army medical university of domestic a few institute 9329 examples a burn case, infect ranking first in the burn cause of death, account for 51.8%; In the analysis large-area burns death of the external single firing damaging the spleen and stomach heart, die to infect accounting for 75%.Infect as fail control, consequently visceral complications again and again, eventually because of septic shock, multiple organ dysfunction syndrome death.So burn infection is outstanding, remove because the destruction of skin barrier is widely arranged, a large amount of sloughs and oozing out have formed outside the good culture medium of microorganism, also with can in time correctly handle wound surface relevant, particularly deep burn wound is the main source of infection, common way is to cut crust in early days, cut the crust skin-grafting, meanwhile utilize antibiotics to control toward contact, yet the pathogenic bacteria of burn wound mostly is many strains, drug resistance is high than other lesiones, during especially to the concurrent systemic infection of serious patient, but a kind of third generation cephalosporin of use in conjunction and a kind of aminoglycoside antibiotics are from intravenous drip; Except Surgery Treatment is equipped with the antibiotics treatment, wound surface also is covered with such as externally used antimicrobial medicines such as 1% silver sulfadiazine cream, iodophors.These externally used antimicrobial medicines are bacteria growing inhibiting to a certain degree, and tissue of burn is separated with health tissues through liquefying by the coagulation necrosis of beginning and needs 2-3 week, in this course, the threat of invasive infection is arranged all at any time.Therapeutic Method in the past because heavy dose of antibiotic that uses, except to the dirty toxic and side effects of Liver and kidney greatly, also often cause dysbacteriosis or superinfection in the body; Also need duty to change dressings at the position that wound surface has infected in addition, remove purulent secretion, the patient that so whenever changes dressings just suffers once painful.The positive operative treatment of the many employings of treatment in recent years comprises and cuts crust in early days or cut crust for this reason, and skin transplantation immediately.And proved that early stage surgical operation can reduce the systemic infection sickness rate, improve the cure rate of large-area burns.But because the burn patients healthy skin remains little, and need dermatoplastic wound surface big, a maximum difficult problem is particularly thorny from body skin " confession " and " asking " in the operation.Although Chinese scholar wound is opened the allograft skin embedding that punches and is planted the measure of fritter from the body skin with big, alleviated the disparities between supply and demand of skin-grafting to a certain extent greatly, still need repair by stages and in groups, thereby postpone leaving hospital the date of patient.

Summary of the invention

The object of the present invention is to provide that a kind of prescription is simple, preparation easily, curative effect rapidly, the hemostasis and pain-relieving bactericidal antiphlogistic, and can effectively prevent or control traumatic infection and cross infection, have no side effect, the patient suffering is little, cost is low, does not stay the pure Chinese medicinal preparation of cicatrix after need not making skin graft, healing.

Raw material components of the present invention and percentage by weight are as follows:

Radix Sanguisorbae 70-80%

Propolis 15-25%

Oleum sesami 4-5%

Reasonable recipe of the present invention has only two flavor active ingredient, Radix Sanguisorbae and propolis.Radix Sanguisorbae is a perennial herb, rosaceous plant.It has hemostasis removing heat from blood, heat-clearing and toxic substances removing, quenches one's thirst to remove and dislike meat and anti-inflammation analgesic effect, rapid for treatment burn and scald curative effect, and can form the thick rete of one deck very soon at wound surface, can effectively prevent and control traumatic infection and cross infection, eliminate pain promotes that wound surface heals rapidly; And propolis is the secreted yellowish-brown such as Apidae insecticide apis cerana Apis Cerana Fabricius or the stickum of pitchy.Its resinous about 50-60%, Cera Flava 30%, fragrant volatile oil 10%.It has the protection granulation tissue, is beneficial to wound healing, and wound repairing is smooth and also effective in cure to chapping.Both compatibilities are given full play to its synergism, add blending agents Oleum sesami again and are more conducive to moistening wound surface, reduce be full of cracks.

The present invention compared with prior art since Radix Sanguisorbae contain a large amount of tannins and glucuronic acid triterpenoid saponin and with the propolis compatibility, and I °, an II ° burn and scald cure rate are reached 100% through clinical observation proof; Severe III ° empyrosis wound surface in the large tracts of land had also pain disappears within the instant effect, the drug of topical application 20 minutes, and the effective main pathogenic bacterium gram negative bacilli of dissipation burn infection, this is that medicine for external use was can't be obtained in the past, meanwhile can also form a thick layer of protecting film in wound surface, effectively prevention and control traumatic infection and cross infection, eliminate pain, promote that wound surface heals rapidly, remove the misery that the patient changes dressings, and the toxic and side effects that can reduce heavy dose of antibiotic consumption and be produced thus; Need not make skin graft again, the urgency that has solved from the body skin lacks problem; More do not stay cicatrix after.Significantly reduce medical expense, shorten the date of being in hospital.

The specific embodiment

The present invention is by implementing to further specify summary of the invention.

Embodiment 1, Radix Sanguisorbae fried be buff and be ground into powder and cross 400 mesh sieves, gets 70 kilograms of Radix Sangusorbae powders and goes in the agitator, add 5 kilograms of Oleum sesami again and stir, go into agitator for 25 kilograms through the propolis of heating 50-55 ℃ after dissolving, stirring is the ointment shape, adorn 1 kilogram/bottle, the sterilization warehouse-in.

Embodiment 2, with embodiment 1 identical condition, get 80 kilograms of Radix Sangusorbae powders and go into agitator, add 5 kilograms of Oleum sesami again and fully stir, and add to adorn 2 kilograms/bottle after 15 kilograms of propolis stir the sterilization warehouse-in.

Embodiment 3, with embodiment 1 identical condition, get 76 kilograms of Radix Sangusorbae powders, 4 kilograms of Oleum sesami fully stir, and add to adorn 2 kilograms/bottle after 20 kilograms of propolis stir the sterilization warehouse-in again.

Application test example 1: Liu, the woman, through being diagnosed as minor burn, wound face reaches 10%, extract blister fluid out with the sterilization hollow needle, the patient is emotionally stable in the drug of topical application 20 minutes, but painless ortho sleep, recovery from illness after 3 days, no cicatrix, skin is smooth, is white in color slightly, recovers the normal colour of skin in two, three months.

Application test example 2: the Wang, belong to shallow II ° burn, injure stratum germinativum, the papillary layer of corium of epidermis.Local red and swollen obviously blister not of uniform size includes faint yellow supernatant liquid, and the hasty and careless pain of fire is burnt in exfoliation, patient's emotion peace and quiet in 20 minutes after the drug of topical application, does not have and infects recovery from illness in the week, has not only had cicatrix but also non-pigment calmness.

Application test example 3: Zhang is through being diagnosed as III ° of burn, whole bark layer burn, even reach subcutaneous, muscle or skeleton.Wound surface does not have blister, is wax white or coke yellow even carbonization, analgesis, local temperature is low, forms eschar after the cortex coagulation necrosis, touch as leather, can show the blood vessel of dendroid thromboembolism under the crust.Because of skin and adnexa thereof all burn, the regenerated source of no epithelium has only the skin-grafting of depending on to heal by the common practice.And after applying medicine of the present invention, eschar came off automatically in 2-3 days, and grow new granulation, wound surface does not have infection, in time change dressings, patient's no pain when changing dressings, sleeping soundly does not all have to wake up, during treating, must strengthen nutritional support, drink Carnis Gallus domesticus soup in order to healing acceleration and skin, the drug of topical application of degree of depth wound surface must put in place more, just can be beneficial to repair the cortex unevenness, changed dressings once in per three days, wound surface does not infect in therapeutic process, does not make skin graft and grows tender skin, has healed during three weeks, obtain ideal therapeutic effect, the patient is emotionally stable, and it is panic restless that spirit does not take place, and smooth no cicatrix of skin and pigmentation, be white in color slightly, treat two, returned to the normal colour of skin in three months.

Claims (1)

1, a kind of pharmaceutical preparation that is used for the treatment of burn and scald is characterized in that the component of its raw material and percentage by weight are as follows:

Radix Sanguisorbae 70-80%

Propolis 15-25%

Oleum sesami 4-5%.