CN101653541A

CN101653541A - Medicinal preparation for treating burn and scald

Info

Publication number: CN101653541A
Application number: CN200810012837A
Authority: CN
Inventors: 孟礼
Original assignee: Individual
Current assignee: Individual
Priority date: 2008-08-19
Filing date: 2008-08-19
Publication date: 2010-02-24

Abstract

The invention relates to a medicinal preparation for treating burn and scald, which is a preferred externally applied agent for treating various levels of burn and scald. The medicinal preparation isprepared from the following raw materials in portion by weight: 0.5 to 2 portions of golden thread, 0.5 to 2 portions of weeping forsythiae capsule, 0.8 to 2 portions of amur corktree bark, 1 to 2 portions of charred sanguisorba, 0.5 to 1 portion of carbonized human hair, 1 to 2 portions of cochinchnese asparagus root, 1 to 2 portions of mongolian snakegourd root, 1 to 2 portions of dahurian angelica root, 0.5 to 1 portions of lightyellow sophora root, 1 to 1.5 portions of liquoric root, 1 to 3 portions of common andrographis herb, 0.5 to 0.8 portion of tree peony bark, 0.5 to 0.8 portion of sinkiang arnebia root, 0.5 to 0.8 portion of safflower, 0.5 to 0.8 portion of borneol and 30 to 65 portions of sesame oil. The medicinal preparation has quick response to inflammation and pain of the wound surface of the burn and scald, obviously relives the pain of a patient after the preparation is applied for more than ten minutes, can kill a predominant pathogen causing infection, namely gram negative bacterium, and can form a layer of protecting film on the wound surface to effectively prevent or control the infection and cross infection of the wound surface.

Description

Be used for the treatment of the pharmaceutical preparation of burn and scald

Technical field

The present invention relates to a kind of Chinese medicine for outer use, relate in particular to a kind of pharmaceutical preparation that is used for the treatment of burn and scald.It is the first-selected medicine for external use of each rank burn and scald of treatment.

Background technology

By the caused tissue injury of heating power general designation burn, as flame, hydrothermal solution, vapours and thermometal or the like.Traumatic condition judges that the most basic requirement is the burn surface area and the degree of depth.Clinical in the past normally according to be slightly or in, the different situations of severe burn dispose respectively, and in, the severe burn person breathes except recording blood pressure, pulse, and notes having or not respiratory tract burn and other associated injuries; Set up the venous transfusion passage immediately, begin transfusion; Indwelling catheter begins debridement, estimation burn surface area, the degree of depth after per hour observing urine amount, proportion, pH value and noting having or not conventional emergency measure such as hemoglobinuria.Should note having or not III especially ⁰The compressing of ring-type eschar, it can influence blood circulation at the limbs position, and metastomium can influence breathing, should cut the eschar decompression.Infection is distinct issues in the treatment burn.According to the analysis that army medical university of domestic a few institute 9329 examples a burn case, infect ranking first in the burn cause of death, account for 51.8%; In the analysis large-area burns death of the external single firing damaging the spleen and stomach heart, die to infect accounting for 75%.Infect as fail control, consequently visceral complications again and again, eventually because of septic shock, multiple organ dysfunction syndrome death.So burn infection is outstanding, except that owing to destruction, a large amount of slough of skin barrier widely arranged and ooze out and formed the good culture medium of microorganism, also with can in time correctly handle wound surface relevant, particularly deep burn wound is the main source of infection, common way is to cut crust in early days, cut crust and plant, and drug resistance is high than other lesion, during especially to the concurrent systemic infection of serious patient, but a kind of third generation cephalosporin of use in conjunction and a kind of aminoglycoside antibiotics are from intravenous drip; Except surgery except being equipped with antibiotics treatment, wound surface also is covered with such as externally used antimicrobial medicines such as 1% silver sulfadiazine cream, iodophors.These externally used antimicrobial medicines are bacteria growing inhibiting to a certain degree, and tissue of burn is separated with health tissues through liquefying by the coagulation necrosis of beginning and needs 2-3 week, in this course, and the threat that all has dipped type to infect at any time.Therapeutic Method in the past because heavy dose of antibiotic that uses, except to the dirty toxic and side effects of Liver and kidney greatly, also often cause dysbacteriosis or superinfection in the body; Also need duty to change dressings at the position that wound surface has infected in addition, remove purulent secretion, the patient that so whenever changes dressings just suffers once painful.The positive operative treatment of the many employings of treatment in recent years comprises and cuts crust in early days or cut crust for this reason, and skin transplantation immediately.And proved that early stage surgical operation can reduce the systemic infection sickness rate, improve the cure rate of large-area burns.If but effective in cure better burn and scald medicine for external use is cooperated, just more can obviously reduce the patient suffering, accelerate healing speed, shorten healing time, can regrettably up to the present not find the comparatively ideal medicine for external use of effect as yet.

Summary of the invention

The object of the present invention is to provide a kind of prescription rationally, preparation easily, curative effect rapidly, the hemostasis and pain-relieving bactericidal antiphlogistic, and can effectively prevent or control traumatic infection, promote healing, change dressings painful little, the unconspicuous Chinese medicine preparation of back cicatrix more.

To achieve these goals, technical scheme of the present invention is as follows:

It is to count ratio by following raw materials in parts by weight to be prepared from Rhizoma Coptidis 0.5-2, Fructus Forsythiae 0.5-2, Cortex Phellodendri 0.8-2, charred Radix Sanguisorbae 1-2, Crinis Carbonisatus 0.5-1, Radix Asparagi 1-2, Radix Trichosanthis 1-2, Radix Angelicae Dahuricae 1-2, Radix Sophorae Flavescentis 0.5-1, Radix Glycyrrhizae 1-1.5, Herba Andrographis 1-3, Cortex Moutan 0.5-0.8, Radix Arnebiae (Radix Lithospermi) 0.5-0.8, Flos Carthami 0.5-0.8, Borneolum Syntheticum 0.5-0.8, Oleum Sesami 30-65.

Advantageous effect of the present invention is as follows:

Prescription of the present invention is scientific and reasonable, gives full play to the synergistic function of every medicine.The composition that hemostasis removing heat from blood, heat-clearing and toxic substances removing are wherein arranged has the anti-inflammation pain relieving to accelerate wound healing again, the effective ingredient of control traumatic infection effect; Eliminate the composition that slough promotes the new granulation effect of growth in addition; Auxiliary again the interpolation is beneficial to the moistening nice and cool minimizing of the wound surface painful auxiliary element of changing dressings.

The present invention compared with prior art; because prescription is scientific and reasonable; and through clinical trial proof to empyrosis wound surface anti-inflammatory analgetic instant effect; tens minutes patients' pain obviously alleviates after the drug of topical application; the sort of originally terribly hot anesthesia reaches endurable degree and falling asleep gradually, simultaneously can dissipation causes the main pathogenic bacterium Glan negative bacillus that infects; meanwhile can also form layer protecting film, and then effectively prevent or control traumatic infection and cross infection in wound surface.Not sticking substantially applying on wound surface when at every turn changing dressings one tears and can open gently, so the patient suffering is little in addition, and more the back cicatrix is slight.These are that medicine for external use was can't be obtained in the past.

The specific embodiment

In conjunction with the embodiments, specifically be described in detail as follows of the present invention:

Embodiment 1

Get respectively in 2 parts of Rhizoma Coptidis, 2 parts of Fructus Forsythiaes, 1 part of Cortex Phellodendri, 2 parts of charred Radix Sanguisorbae, 0.5 part of Crinis Carbonisatus, 2 parts of Radix Asparagi, 1 part of Radix Trichosanthis, 2 parts of the Radixs Angelicae Dahuricae, 0.5 part of Radix Sophorae Flavescentis, 1 part in Radix Glycyrrhizae, 2 parts of Herba Andrographis, 0.5 part of Cortex Moutan, 0.5 part of Radix Arnebiae (Radix Lithospermi), 65 parts of Oleum Sesami of 0.5 part of immersion of Flos Carthami by the proportioning of prescription, slow fire boiling is removed slag when expecting that medicine is coke yellow, treat to put into 0.5 part of Borneolum Syntheticum powder bundle after cold slightly, autoclaving sterilization after stirring, fill 500ml/ bottle.

Embodiment 2

With embodiment 1 identical preparation method, get 1 part of Rhizoma Coptidis, 0.8 part of Fructus Forsythiae, 2 parts of Cortex Phellodendris, 1 part of charred Radix Sanguisorbae, 1 part of Crinis Carbonisatus, 1 part of Radix Asparagi, 2 parts of Radix Trichosanthis, 1 part of the Radix Angelicae Dahuricae, 1 part of Radix Sophorae Flavescentis, 1.5 parts in Radix Glycyrrhizae, 1 part of Herba Andrographis, 0.8 part of Cortex Moutan, 0.8 part of Radix Arnebiae (Radix Lithospermi), Flos Carthami respectively by formulation ratio and immerse in 30 parts of Oleum Sesami for 0.8 part and decocts with embodiment 1 the same terms, remove slag, add after cold slightly that 0.6 part of Borneolum Syntheticum stirs, sterilization, pack.

Embodiment 3

Get that 0.6 part of 0.5 part of Rhizoma Coptidis, 1 part of Fructus Forsythiae, 1.5 parts of Cortex Phellodendris, 1.5 parts of charred Radix Sanguisorbae, 0.8 part of Crinis Carbonisatus, 1.5 parts of Radix Asparagi, 1.5 parts of Radix Trichosanthis, 1.5 parts of the Radixs Angelicae Dahuricae, 0.5 part of Radix Sophorae Flavescentis, 1.2 parts in Radix Glycyrrhizae, 3 parts of Herba Andrographis, 0.6 part of Cortex Moutan, 0.6 part of Radix Arnebiae (Radix Lithospermi), Flos Carthami is immersed in 40 parts of Oleum Sesami, the same procedure preparation of 0.6 part of Borneolum Syntheticum and example 1, pack.

Application Example 1, the Zhang man, reached 10% through being diagnosed as the minor burn wound surface in 45 years old, extract blister fluid out with the sterilization hollow needle, after the wound surface cleaning sterilization, with liquid medicine coating of the present invention after on the wound surface, above the hospital gauze that scribbles the soft ointment of very thin one deck covered, patient's pain of liniment unbearably, emitting a groan frequently, a drug of topical application 10-20 minute patient is emotionally stable gradually, pain relief reaches endurable degree, not sleeping gradually, when change dressings next day with tweezers gently once taking off the gauze of tearing, the patient does not have pain sensation basically, is almost recovered after three days, does not have fever yet, infect, skin is smooth, cicatrix is not obvious, is shallow white, two, recovered the normal colour of skin in three months.

Application Example 2, certain woman that shuts out were burnt through being diagnosed as II in a fire in 38 years old ⁰Burn; injure stratum germinativum, the papillary layer of corium of epidermis; local red and swollen; blister not of uniform size; include faint yellow supernatant liquid, exfoliation, terribly hot pain is unbearably; 20-30 minute patient's emotion tends towards stability gradually after the drug of topical application; change medicine every day twice, do not have infection fever, the sound sleep of just sleeping after 3 days; antibiotic useless in this process; the wound surface slough is eliminated and is grown new granulation gradually, and the surface forms layer protecting film, is almost recovered after the week; there is not clear scar non-pigment calmness again, the rest of leaving hospital.

Application Example 3, Chen man 42 years old is through being diagnosed as III ⁰Burn, whole bark layer burn, local even reach subcutaneous, muscle or skeleton.Wound surface does not have blister, is wax white or coke yellow even carbonization, analgesis, local temperature is low, forms eschar after the cortex coagulation necrosis, touch as leather and fur, can show the blood vessel of dendroid thromboembolism under the crust.Because skin and adnexa thereof all burn, the regenerated source of no epithelium is after having only the skin-grafting of depending on to heal by the common practice.The patient bears painful big, and the cycle is grown and adopts positive operative treatment, and comprise and cut crust in early days or cut crust, and skin transplantation immediately.Reuse medicine partner treatment of the present invention.Apply medicine of the present invention, apply twice every day, and the drug of topical application must put in place to degree of depth wound surface, in order to repairing the skin unevenness.Wound surface grows new granulation after 5 days, wound surface does not have infection, the patient is sleeping soundly but is not waking up when changing dressings, meanwhile must strengthen nutritional support during the treatment, as drink more chicken soup sharp quicken more and and skin, heal after three weeks, wound surface does not infect in therapeutic process, this is rare in this class treatment in the past, has obtained ideal therapeutic effect.

Although more than be limited model case, also fully prove analgesic antiphlogistic, control infection, the minimizing patient suffering of medicine of the present invention to light, middle severe burn wound surface, shortening healing time all has obvious effects.Particularly at treatment III ⁰Large-area burns patient and surgical operation therapeutic alliance have more obtained gratifying effect.

Claims

1, a kind of pharmaceutical preparation that is used for the treatment of burn and scald, it is characterized in that counting ratio by following raw materials in parts by weight is prepared from Rhizoma Coptidis 0.5-2, Fructus Forsythiae 0.5-2, Cortex Phellodendri 0.8-2, charred Radix Sanguisorbae 1-2, Crinis Carbonisatus 0.5-1, Radix Asparagi 1-2, Radix Trichosanthis 1-2, Radix Angelicae Dahuricae 1-2, Radix Sophorae Flavescentis 0.5-1, Radix Glycyrrhizae 1-1.5, Herba Andrographis 1-3, Cortex Moutan 0.5-0.8, Radix Arnebiae (Radix Lithospermi) 0.5-0.8, Flos Carthami 0.5-0.8, Borneolum Syntheticum 0.5-0.8, Oleum Sesami 30-65.

2, the pharmaceutical preparation that is used for the treatment of burn and scald according to claim 1, it is characterized in that counting ratio by following raw materials in parts by weight is prepared from Rhizoma Coptidis 1, Fructus Forsythiae 0.8, Cortex Phellodendri 2, charred Radix Sanguisorbae 1, Crinis Carbonisatus 1, Radix Asparagi 1, Radix Trichosanthis 2, the Radix Angelicae Dahuricae 1, Radix Sophorae Flavescentis 1, Radix Glycyrrhizae 1.5, Herba Andrographis 1, Cortex Moutan 0.8, Radix Arnebiae (Radix Lithospermi) 0.8, Flos Carthami 0.8, Borneolum Syntheticum 0.8, Oleum Sesami 30.