CN100518794C - Burn cream - Google Patents
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- CN100518794C CN100518794C CNB2006100685292A CN200610068529A CN100518794C CN 100518794 C CN100518794 C CN 100518794C CN B2006100685292 A CNB2006100685292 A CN B2006100685292A CN 200610068529 A CN200610068529 A CN 200610068529A CN 100518794 C CN100518794 C CN 100518794C
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Abstract
The invention discloses a medicinal ointment for treating burns, wherein the active constituents mainly compirse alkanna tinctoria, baikal skullcap root, goldthread root, corktree bark, rhubarb horsetails, giant knotweed rhizome, bletilla striata, root of red rooted saliva, garden burnet root and auxiliary materials including excipient and sesame oil.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of burn, scalding, especially a kind of is the treatment burn of feedstock production, the medicine of scalding with the Chinese herbal medicine.
Background technology
Burn and scald are a kind of commonly encountered diseases, frequently-occurring disease, and medication rationally and effectively is the critical treatment means that promote wound healing to its wound surface.Burn wound's medicine for external use kind is more, at present clinical commonly used have moist expose burn ointment, JINGWANHONG etc., basic hospital is used more especially with moist expose burn ointment, but above medicine is not ideal enough in aspect effects such as control traumatic infections, and the side effect that is caused also often has report.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of traditional Chinese medicines burn cream, to improve therapeutic effect.
The present invention is achieved in that the traditional Chinese medicines burn cream, and described burn cream is made by effective ingredient and adjuvant, and effective ingredient is Radix Arnebiae (Radix Lithospermi), Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, Rhizoma Polygoni Cuspidati, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Salviae Miltiorrhizae, Radix Sanguisorbae, and adjuvant is excipient, Oleum Sesami, and its weight proportion is
Radix Arnebiae (Radix Lithospermi) 100～200 weight portions
Radix Scutellariae 100～200 weight portions
Rhizoma Coptidis 100～200 weight portions
Cortex Phellodendri 100～200 weight portions
Radix Et Rhizoma Rhei 100～200 weight portions
Rhizoma Polygoni Cuspidati 100～200 weight portions
The Pseudobulbus Bletillae (Rhizoma Bletillae) 100～200 weight portions
Radix Salviae Miltiorrhizae 100～200 weight portions
Radix Sanguisorbae 100～200 weight portions
Excipient 100～130 weight portions
Oleum Sesami 2000～4000 weight portions.
The technical scheme of this burn cream is by secular clinical observation and deep analysis and research, emphasis is from solve promoting wound healing, control traumatic infection, reduce patient's misery, do not stay or stay less cicatrix to start with, and the optimization of having carried out decades from prescription and medicine aspect is preferred and obtain.Medicament contg in this burn cream improves, and antibacterial action strengthens, and promotes the compositions such as trace element of wound healing to increase.
Clinical use result shows that the present invention's burn cream has following advantage:
1. the present invention selects natural Chinese medicine for use, does not add any chemical addition agent, utilizes the effect advantage of each medicine, controls traumatic infection effectively, and to the wound surface nonirritant.
2. medicine of the present invention promotes wound healing effectively, obviously shortens wound healing time, the epithelial tissue that safekeeping is residual, and quicken epithelial cell growth.
3. medicine analgesic effect of the present invention is obvious, does not have systemic adverse reactions in the patient process, the treatment cooperation, and the patient comfort is good, and is painful few, and good compliance is arranged.
4. scar hyperplasia is not obvious after the Drug therapy of the present invention, and pigmentation is light, and the pruritus symptom is not obvious.
5. medicine expense of the present invention is cheap, and medicine is easy to get, and preparation technology is simple, and is easy to use.
The specific embodiment
Further specify the present invention below.
In the present invention's the burn cream, the preferred weight proportioning of each raw material is
Radix Arnebiae (Radix Lithospermi) 150～200 weight portions
Radix Scutellariae 150～200 weight portions
Rhizoma Coptidis 150～200 weight portions
Cortex Phellodendri 150～200 weight portions
Radix Et Rhizoma Rhei 150～200 weight portions
Rhizoma Polygoni Cuspidati 150～200 weight portions
The Pseudobulbus Bletillae (Rhizoma Bletillae) 150～200 weight portions
Radix Salviae Miltiorrhizae 150～200 weight portions
Radix Sanguisorbae 150～200 weight portions
Excipient 100～130 weight portions
Oleum Sesami 3000～4000 weight portions.
Described excipient is medical ventolin or Cera Flava.
A kind of preparation method of the present invention's burn cream is: after above-mentioned Chinese medicine is cleaned, dry, take out Radix Arnebiae (Radix Lithospermi) and singly put, other Chinese medicine appropriateness is pulverized, and is crushed to the niblet size, Oleum Sesami is heated to 150～180 ℃, put into fried getting 25～30 minutes such as Radix Scutellariae after the pulverizing, Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, Rhizoma Polygoni Cuspidati, Radix Salviae Miltiorrhizae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Sanguisorbae, drag for and put into that Radix Arnebiae (Radix Lithospermi) is fried got 8～10 minutes after removing slag, filter, after the cooling, put into excipient again, get the present invention's burn cream.
Be the medicine that the shows the present invention therapeutic effect to burn and scald, we have carried out systematic study from zoopery and clinical practice two aspects.
One, the traditional Chinese medicines burn cream is to the experimentation of rabbit burn model
1. material and method
1.1 experimental drug the present invention's traditional Chinese medicines burn cream; JINGWANHONG, Tianjin Darentang Pharmaceutical Factory production, lot number is 20020218.
1.2 irritant experiment is got 10 of Cavia porcelluss, back 8% Na
2S solution depilation, separate application this product behind the 24h, and observe skin in 0.5h, 1h, 2h, 4h, 8h, 16h, 24h, and phenomenons such as no skin rubefaction, edema, the burn cream that the present invention is described is to laboratory animal skin nonirritant.
1.3 64 of the healthy rabbits that laboratory animal is provided by Bingzhou Vocational College's Experimental Animal Center, the male and female dual-purpose about body weight 2kg, is divided into traditional Chinese medicines burn cream test group and JINGWANHONG matched group (being called for short test group and matched group) at random.
1.4 two groups of rabbit of experimental technique are all used 8%Na
2The S aqueous solution is to its back depilation, be coated with then with 10% solidified gasoline, burnt respectively 5 seconds, 10 seconds, 15 seconds, 20 seconds, and made burn surface area and be 20 of 10% I degree burns, 12 of shallow II degree burns, 12 of deep ii degree burns, (press Wu Zaide chief editor, People's Health Publisher calendar year 2001, the 5th edition " surgery ", the 216th～224 page, the degree of depth is spent quarterings by three for 20 of III degree burns, area is pressed rule of Nine, and does pathology section confirmation).Every the rabbit in burn back is replenished normal saline 15ml in the abdominal cavity immediately, and two groups of rabbit one cages are raised.
The back 2 hours beginning external used medicines of burning, initial 3 days, per 6 hours coatings once, later every day, coating was 3 times, the wound surface thickness of covering is about 2mm, in time each wound surface is done pathological section.Observe activity, feed and the spontaneous activity situation of every rabbit, write down two groups of rabbit burn wound healing times and cicatrization situation.
2. result's (seeing Table 1).
Table 1 burn wound The average healing and cicatrization situation
Annotate: * P＜0.01, two groups all there were significant differences for dark II degree and III degree burn wound healing time and cicatrization rate
Two groups of healing rate no significant differences 2.1 wound healing situation I degree is burnt, because of the burn degree is lighter, healing is very fast, weak point person 5 days, elder 9 days; Shallow II degree is burnt two groups does not also have significant difference, weak point person 12 days, elder 16 days; The deep ii degree burn healing time has significant difference for two groups, test group weak point person 29 days, elder 35 days, matched group weak point person 37 days, elder 46 days, two groups of significant differences (P＜0.01); III degree burn is more obvious, the shortest person of test group 43 days, and elder 54 days, the shortest person of matched group 64 days, elder 73 days, two groups have significant difference (P＜0.01).
2.2 cicatrization situation I degree, shallow II degree all do not stay cicatrix, dark II degree and III degree burn have cicatrization, test group to have 4, account for 12.5%, and matched group has 10, accounts for 31.25%.The cicatrix of test group is lighter, and feel is softer, and the matched group feel is harder, and cicatrix is obvious, and being masked as of cicatrix exceeds skin and be streak, the blocky fibroplasia of sheet.
2.3 the traumatic infection situation is for small-area burn in the shallow II degree, infecting seldom appears in test group, and no pathogenic bacterium growth is cultivated in sampling, because wound surface is more shallow, does not influence healing time; Above two groups 32 the rabbit wound surface bacterial infection situations of the dark II degree of random observation, sampling is cultivated 1 time weekly, detects altogether 5 times, and the result has marked difference for two groups, and infectious bacteria is mainly (seeing Table 2) such as streptococcus.
Table 2 burn wound infection conditions
Annotate: * P＜0.01, medication group and matched group significant difference
2.4 the epidermis cell of pathological change rabbit skin of back after napalm burn, dermic hair follice epithelial cell, fiber finer karyon disappear, skin corium part collagen merges to be has a liking for Yihong laminated structure.There are a large amount of cell infiltration slough and living tissue battery limit (BL), and the above burn of dark II degree back 5 days does not have obvious difference for two groups, does not have granulation substantially and forms, and the granulation tissue of test group forms significantly more than matched group (seeing Table 3) after 10 days.Do liver, nephropathy reason after the shallow II degree burn rabbits wound repair, the result is no abnormal.
10 days wound surface granulation tissuies of the dark above burn rabbits of II degree of table 3 form situation
Annotate: the medication group has been compared significant difference (P＜0.01) with matched group.
3 discuss
3.1 Rhizoma Polygoni Cuspidati in anti-traumatic infection problem the present invention's the burn cream prescription, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, medicines such as Radix Et Rhizoma Rhei have heat-clearing and toxic substances removing, cooling blood for hemostasis, blood circulation promoting and blood stasis dispelling, antibiotic pain relieving, the convergence granulation promoting, reduce and effect such as to ooze out, the traditional Chinese medicines burn cream is covered in wound surface, wound surface and outside air are isolated, antibacterial is difficult to directly contact with wound surface, the wound surface bacterial content reduces, the infection probability reduces, the covering of wound surface has also reduced that wound surface oozes out and water evaporates simultaneously, reduce losing of body moisture, alleviate edema wound, help wound surface slough and secretions drain and mediate, make the wound surface cleaning, promote microcirculatory formation, improve burn wound's local microcirculation, promoted the reparation and the healing of wound surface greatly.
3.2 the possible mechanism of short wound healing 1. this burn cream can promote the continuous hypertrophy of wound surface new capillary vessel, improve the transportation function of endotheliocyte, the wound surface capillary permeability is increased, the liquefaction thereby the inanimate slough cell of promotion wound surface, rotten thing come off, present drainage, thereby the wound surface finding of naked eye has the more tasteless liquefaction thing that oozes out, and helps growing granulation and " skin island "; 2. the activation of this burn cream makes the activating cell and the immunocompetence factor move in wound surface from blood capillary, regulates mutually, and the wound surface cell function is strengthened, and extracellular matrix increases, and provides necessary condition for quickening wound healing; 3. local antibacterial effect: antimicrobial component is many in this burn cream, and antibacterial action is obvious, and the antibacterial that is attached to wound surface is had direct inhibition or killing action, has contained the breeding growth of antibacterial, has effectively controlled traumatic infection; 4. this burn cream is covered in wound surface, has avoided exsiccant damage, has promptly avoided burn back epidermis or corium further damage and large quantity of moisture evaporation and a large amount of dehydrations of tissue, stops necrotic extent to be deepened.Traditional Chinese medicines burn cream energy microcirculation improvement is expanded the blood capillary of thromboembolism again, sets up recirculation, to improve histiocyte ischemia, anoxybiotic undesirable condition, dwindles the tissue necrosis scope; 5. the liquefaction of this burn cream is flowed, and makes slough and metabolite such as thromboxane A
2, prostaglandin, 5-hydroxy tryptamine, the platelet IV factor, antigen antibody complex etc. be able to timely removing, eliminated the hypoxic-ischemic situation, in order to regeneration, meets histological Regeneration and Repair theory.
4. conclusion
The traditional Chinese medicines burn cream proves that to the experimentation of rabbit burn model it can reduce traumatic infection, shortens wound healing time, reduce cicatrization etc., for clinical practice is had laid a good foundation.
Two, the clinical observation material of the present invention's burn cream.
1, case is selected to select 86 routine patients to use the case of traditional Chinese medicines burn cream to organize as treatment from year October in May, 2004 to 2005, randomly draws the case of 86 example application moist expose burn ointments in addition and organizes in contrast.Wherein male 137 examples, women 41 examples.32.61 ± 13.53 years old mean age, burn surface area 12.60% ± 10.19%.Flame burn 54 examples, hydrothermal solution is scalded 81 examples, electric arc burn 14 examples, acid burn 21 examples, other 2 examples (seeing table 1,2,3 for details).Two groups of ages, the state of an illness are suitable substantially, and comparability is arranged.
Table 1 burn surface area, degree of depth situation
Annotate: no difference of science of statistics between treatment group and matched group burn surface area and the degree of depth constituent ratio (P〉0.05)
Table 2 fire victim age, sex situation
Annotate: no difference of science of statistics between treatment group and the matched group fire victim age structure ratio (P〉0.05)
Table 3 fire victim traumatogenic reason situation
Annotate: no difference of science of statistics between treatment group and the matched group fire victim traumatogenic reason constituent ratio (P〉0.05)
The clinical II degree burn wound that all is judged to be of above-mentioned case, wound surface burn deciding degree adopts three degree quarterings international and that China is general.
2, administrated method is at first to burn wound's debridement: 0.5% povidone iodine or the flushing of hibitane weak solution, remove beancurd sheet.Select the identical or close ∏ degree of area wound surface, respectively with traditional Chinese medicines burn cream, moist expose burn ointment coating wound surface.Neck surface wound surface and trunk many places are dispersed in wound surface employing exposure or half exposure treatment, and exposure is treated and was smeared once in per 4～6 hours, changes dressings the next day of half exposure treatment; Surplus employing bandaging method for treating, medication thickness 1mm changed dressings once in per 3 days.Two groups of administration times, medication number of times and modes are all identical.
Clinical indices is observed: 1. wound healing mode; 2. analgesic effect in the therapeutic process; 3. traumatic infection degree; 4. side effect such as allergy; 5. cicatrix incidence rate.
3, result
1, wound healing mode and time: treatment group, matched group wound healing time see table 4 for details.
Table 4 treatment group, matched group Wound treating II degree burn wound healing natural law
Annotate: curing big number treatment group and matched group has notable difference (p＜0.01)
2, patient's analgesic effect:, divide following 5 ranks according to pain relief situation after the medication.Excellent: wound pain is alleviated in the medication 10 minutes; Very: wound pain alleviates in the medication 10 minutes, alleviates in 30 minutes; In: wound pain alleviates in the medication 30 minutes, without analgesic drug product; Difference: wound pain does not have and alleviates in the medication 30 minutes, needs use the analgesic drug product pain relieving; Extreme difference: wound pain increases the weight of in the medication 30 minutes, needs with analgesic drug product pain relieving (seeing table 5 for details).
Table 5 wound surface analgesic effect situation
Annotate: between two groups of excellent comparable group, significant differences (P＜0.01) is arranged
The result shows that treatment is formed face medication analgesic effect and obviously is better than matched group wound surface (P＜0.01).So adopt the patient of the present invention's burn cream treatment, needn't consider that in treatment with during changing dressings wound surface can cause pain and hemorrhage because of changing dressings, and the matched group wound surface need be used analgesic drug product where necessary, and take the protectiveness measure of changing dressings.
3, traumatic infection situation: with the reaction of edge of wound inflammatory infiltration, empyema under the crust, cambium necrosis or growth retardation generation and hyperpyrexia (body temperature is more than 38.5 ℃) are judged index (seeing table 6 for details) as gradient of infection.
Table 6 II degree traumatic infection incidence rate relatively
Annotate: above infection index and infection rate, treatment group and matched group have significant differences (P＜0.01)
4, scar hyperplasia situation: we carried out after to dark ∏ degree wound healing 6 months to 1 year with examining, find that treatment forms the face scar formation rate and be starkly lower than the matched group wound surface.
The cicatrix incidence rate relatively behind the dark II degree wound healing of table 7
Annotate: all do not stay cicatrix behind the shallow II degree wound healing, cicatrix incidence rate and cicatrix area behind the dark II degree wound healing, the treatment group all is starkly lower than matched group, and significant differences (P＜0.01) is arranged.
From above therapeutic outcome analysis, the present invention's burn cream anti-infection ability is strong.Burn wound is the main door of burn infection, and therefore controlling traumatic infection is to promote wound healing, improves the burn cure rate and the most important condition that shortens the hospital stays.Except systemic comprehensive treatment, the more important thing is the wound surface processing.Burn wound's types of medicines is various, and there is very big-difference in the medicining condition of each hospital in all parts of the country.It is more that basic hospital is used moist expose burn ointment in recent years, increases the weight of to have report but use the back traumatic infection more.Report is arranged, and neutrophilic granulocyte and endothelial cell adhesion are one of major reasons that causes the intensification of dark carrying out property of II degree wound surface.
In the selection of burn wound's medicine for external use, should follow two and help principle: help infection, help promoting that organizing epithelial cell growth, final purpose is quick epithelization.The medication of ideal burn wound should be satisfied needs biology (keep moist environment, reduce and ooze out, protect from infection); Satisfy patient's needs (good analgesic effect, wound healing is fast, price is low); Satisfy medical care administration personnel needs (easy and simple to handle, reduce workload, safety is good).As starting point, contain compositions such as Rhizoma Polygoni Cuspidati, Radix Arnebiae (Radix Lithospermi) as the present invention's of burn wound's medicine for external use burn cream, have heat-clearing and toxic substances removing, cooling blood for hemostasis, activating blood circulation to dissipate blood stasis, antibiotic pain relieving, convergence granulation promoting, reduce effect such as the detumescence of oozing out, lower the temperature.Its treatment burn and scald has following innovation characteristic: can improve blood circulation, improve the parabiosis tissue, correct the stasis band blood confession of recovery burn wound, avoid the dry damage of wound surface, epidermis or the damage of carrying out property of corium after both having avoided burning stop necrotic extent to be deepened; It is covered in the wound surface surface on the other hand; form layer protecting film; the infringement of isolated environmental stimuli and pollution and defence pathogen; reduce and infect probability, reduce wound surface and ooze out, alleviate edema wound; promote wound surface slough and secretions drain and drainage; make tissue keep normal repair function, the epithelial tissue that safekeeping is residual keeps the wound surface cleaning.Particularly improve the microcirculation that deep ii degree burn is retarded by silt and is with, the protection parabiosis is organized particularly important.Because the degree of depth of burn wound has an evolution process in early days, if the band that is retarded by silt increases the weight of to expand to holostrome skin gradually, cause that just the holostrome SkBF stops and necrosis, form III degree wound surface; Otherwise, just can avoid wound surface deepening if can improve the microcirculation of the band that is retarded by silt.Traditional Chinese medicines burn cream infection mechanism is relevant with the synergism of each Chinese medicinal ingredients, promotes the continuous hypertrophy of new capillary vessel on the one hand, improves the transportation function of endotheliocyte, and the wound surface capillary permeability is increased, and presents drainage; On the one hand the activating cell and the immunocompetence factor are moved in wound surface, strengthen cell function, regulate immunity of organism, quicken wound healing.
According to clinical observation, sepage has remarkable minimizing after discovery application the present invention's the burn cream, helps to reduce the wound surface exudate, but whether is reduced the shock amount infused for the burn patients shock stage, waits further observational study.
In patient temperature is observed, consider that tissue absorbs heat and the heating of patient's irritability, with 38.5 ℃ be benchmark, find that the heating of treatment group is many below 38.5 ℃, with one property see more; Matched group heating is based on continued fever, 1 an example heat of speeding arranged, 1 routine pyemia.
Traditional Chinese medicines burn cream good analgesic effect, patient comfort's height.Burn back pain therapy is the problem of burn clinical research always.Mostly burn pain is because burn wound discharges due to a large amount of pain factors, especially shallow ∏ degree wound surface, and its damage is positioned at the sensation corpusculum of cutaneous nerve tip, and pain is particularly violent.Over-drastic pain discomfort can increase the weight of stress, and attitude is stable in the influence tissue, increases energy expenditure.The present invention's burn cream is covered in the wound surface surface, makes wound surface and air insulated, blocks the K that cell discharged that causes injury
+Ion contacts with air, eases the pain; The liquid flow of this ointment makes slough and metabolite such as thromboxane A
2, prostaglandin, 5-hydroxy tryptamine, the platelet IV factor, antigen antibody complex etc. be able to timely removing, eliminated the hypoxic-ischemic situation, to a certain degree alleviated pain.Stimulate for a short time after the clinical data treatment group patient medication, pain relieving is fast, and infant is quiet or the degree of crying and screaming is poor, and analgesic effect is obvious, and patient process whole body has no adverse reaction, treatment cooperation, patient comfort's height.
Use the present invention's burn cream healing back and observe with the people that diagnoses a disease, scar hyperplasia is not obvious, and pigment alteration is light, and the pruritus symptom is lighter.The formation of cicatrix is main relevant with other factors such as individual physique, inflammation, infection.Broadly say do not have wound healing without scar tissue.But over-drastic scar hyperplasia just can influence function and outward appearance.In view of the infringement that hypertrophic cicatrix and keloid cause body, its be otherwise known as " skin trauma of healing property ".And the rational and effective processing can reduce the scar hyperplasia rate to a certain extent.This clinical trial does not all have scar hyperplasia to 81 routine shallow II degree wound surface case treatment groups and matched group, but the matched group healing time is obviously long partially, and finds that 3 routine pigment alterations are obvious.In the dark II degree wound surface case of 97 examples, the contrast of scar hyperplasia rate obviously.Treatment group patient scar hyperplasia is not obvious may be relevant with following two aspects: 1. the infection of traditional Chinese medicines burn cream reaches by force and promotes quick epithelization characteristics, and healing time is shortened, and alleviates or reduce the hypertrophy of cicatrix; 2. to compare wound secretion on the low side with burn cream in the traditional Chinese medicines burn cream application process, and drain is unobstructed.3. multiple pharmaceutical compositions synergism in the traditional Chinese medicines burn cream, activating blood circulation to dissipate blood stasis, hard masses softening and resolving, it can improve peripheral termination of nerve anoxia and microcirculation hypoxic-ischemic situation, saves the parabiosis tissue, thereby helps suppressing scar hyperplasia.
In sum, the traditional Chinese medicines burn cream studies have shown that in Clinical Application, it has, and infection is strong, good analgesic effect, help epithelial cell growth, use easy, have no side effect, do not have characteristics such as sensitization, cicatrix incidence rate are low.Its medicine source is abundant and price is low, and compound method is simple, and preparation method is simple, can reduce workload, and is easy to carry, especially is fit to grass-roots community's hospital clinical and promotes the use of.
Embodiment 1: take by weighing raw material by following proportioning: Radix Arnebiae (Radix Lithospermi) 150g, Radix Scutellariae 150g, Rhizoma Coptidis 180g, Cortex Phellodendri 160g, Radix Et Rhizoma Rhei 170g, Rhizoma Polygoni Cuspidati 190g, Pseudobulbus Bletillae (Rhizoma Bletillae) 200g, Radix Salviae Miltiorrhizae 160g, Radix Sanguisorbae 130g, medical ventolin 100g, Oleum Sesami 3000g.
Preparation method is: after above-mentioned Chinese medicine is cleaned, dry, take out Radix Arnebiae (Radix Lithospermi) and singly put, other Chinese medicine appropriateness is pulverized, and it is big to be crushed to niblet, Oleum Sesami is heated to 170 ℃, put into fried getting 28 minutes such as Radix Scutellariae after the pulverizing, Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, Rhizoma Polygoni Cuspidati, Radix Salviae Miltiorrhizae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Sanguisorbae, drag for and put into that Radix Arnebiae (Radix Lithospermi) is fried got 9 minutes after removing slag, filter, after the cooling, put into the excipient medical ventolin again, get the present invention's burn cream.
Embodiment 2: take by weighing raw material by following proportioning: Radix Arnebiae (Radix Lithospermi) 110g, Radix Scutellariae 120g, Rhizoma Coptidis 180g, Cortex Phellodendri 190g, Radix Et Rhizoma Rhei 170g, Rhizoma Polygoni Cuspidati 200g, Pseudobulbus Bletillae (Rhizoma Bletillae) 150g, Radix Salviae Miltiorrhizae 170g, Radix Sanguisorbae 140g, Cera Flava 120g, Oleum Sesami 3000g.Preparation method is the same.
Embodiment 3: take by weighing raw material by following proportioning: Radix Arnebiae (Radix Lithospermi) 130g, Radix Scutellariae 140g, Rhizoma Coptidis 160g, Cortex Phellodendri 170g, Radix Et Rhizoma Rhei 140g, Rhizoma Polygoni Cuspidati 160g, Pseudobulbus Bletillae (Rhizoma Bletillae) 150g, Radix Salviae Miltiorrhizae 190g, Radix Sanguisorbae 150g, medical ventolin 130g, Oleum Sesami 4000g.Preparation method is the same.
Claims (2)
1, a kind of burn cream is characterized in that, described burn cream is made by effective ingredient and adjuvant, and effective ingredient is Radix Arnebiae (Radix Lithospermi), Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, Rhizoma Polygoni Cuspidati, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Salviae Miltiorrhizae, Radix Sanguisorbae, and adjuvant is excipient, Oleum Sesami, and its weight proportion is
Radix Arnebiae (Radix Lithospermi) 100～200 weight portions
Radix Scutellariae 100～200 weight portions
Rhizoma Coptidis 100～200 weight portions
Cortex Phellodendri 100～200 weight portions
Radix Et Rhizoma Rhei 100～200 weight portions
Rhizoma Polygoni Cuspidati 100～200 weight portions
The Pseudobulbus Bletillae (Rhizoma Bletillae) 100～200 weight portions
Radix Salviae Miltiorrhizae 100～200 weight portions
Radix Sanguisorbae 100～200 weight portions
Excipient 100～130 weight portions
Oleum Sesami 2000～4000 weight portions.
2, burn cream as claimed in claim 1 is characterized in that, the weight proportion of each raw material is
Radix Arnebiae (Radix Lithospermi) 150～200 weight portions
Radix Scutellariae 150～200 weight portions
Rhizoma Coptidis 150～200 weight portions
Cortex Phellodendri 150～200 weight portions
Radix Et Rhizoma Rhei 150～200 weight portions
Rhizoma Polygoni Cuspidati 150～200 weight portions
The Pseudobulbus Bletillae (Rhizoma Bletillae) 150～200 weight portions
Radix Salviae Miltiorrhizae 150～200 weight portions
Radix Sanguisorbae 150～200 weight portions
Excipient 100～130 weight portions
Oleum Sesami 3000～4000 weight portions.
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| CNB2006100685292A CN100518794C (en) | 2006-08-21 | 2006-08-21 | Burn cream |
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| CNB2006100685292A CN100518794C (en) | 2006-08-21 | 2006-08-21 | Burn cream |
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| CN100518794C true CN100518794C (en) | 2009-07-29 |
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Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101612290B (en) * | 2008-06-27 | 2012-11-21 | 李伟芳 | Medicinal composition for treating burn and scald and preparation method thereof |
| CN101721500B (en) * | 2008-10-17 | 2012-01-25 | 上海交通大学医学院附属瑞金医院 | Composition and preparation method and application thereof |
| CN102429986B (en) * | 2010-09-29 | 2013-10-16 | 董析颖 | Traditional Chinese ointment for treating burn and scald and preparation method thereof |
| CN102198212B (en) * | 2011-05-20 | 2012-11-21 | 赵立珍 | Chinese medicinal liquid for treating burns and scalds and preparation method thereof |
| CN102274331A (en) * | 2011-08-05 | 2011-12-14 | 潘火贤 | Cool pain-alleviating ointment for burns and scalds and preparation method |
| CN102389483B (en) * | 2011-11-18 | 2013-05-08 | 田旺富 | Scald ointment |
| CN102743515B (en) * | 2012-07-10 | 2014-03-12 | 于传伍 | Traditional Chinese medicine ointment for treating burn and scald |
| CN103656205A (en) * | 2012-09-04 | 2014-03-26 | 三门峡乐华康源生物科技有限责任公司 | Burn oil and preparation method thereof |
| CN103110818B (en) * | 2012-12-25 | 2015-05-13 | 新疆维吾尔自治区药物研究所 | Compound medicinal powder for burning and preparation method thereof |
| CN104840749B (en) * | 2015-05-20 | 2018-06-08 | 泸州康德缘医药科技开发有限公司 | A kind of externally-applied ointment and preparation method treated skin trauma and be free of heavy metal |
| CN105147881A (en) * | 2015-10-28 | 2015-12-16 | 李琳 | Compound menthol balm for treating burns |
| CN105663372A (en) * | 2016-02-26 | 2016-06-15 | 彭万正 | Multifunctional burn cream and preparation method thereof |
| CN107693694A (en) * | 2017-06-12 | 2018-02-16 | 上海康漾生物科技有限公司 | A kind of burning for fresh open wound creates medicine |
| CN110680878A (en) * | 2018-07-13 | 2020-01-14 | 莆田市肤宝生物科技有限公司 | Preparation method of ointment for treating burns and scalds |
| CN111494551A (en) * | 2020-05-26 | 2020-08-07 | 吴德炳 | Traditional Chinese medicine composition for treating burns and scalds, traditional Chinese medicine preparation and application thereof |
| CN111588835A (en) * | 2020-06-24 | 2020-08-28 | 谢岩 | Mixture for treating burn wound |
| CN112022963A (en) * | 2020-09-18 | 2020-12-04 | 刘菊英 | Chinese herbal medicine patch for external application for relieving swelling and pain |
| CN116270828B (en) * | 2023-05-11 | 2024-01-26 | 济南市中医医院 | Traditional Chinese medicine composition for wound healing and preparation method thereof |
-
2006
- 2006-08-21 CN CNB2006100685292A patent/CN100518794C/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 外用中医药制剂治疗烧伤的进展. 郭静，张毅.中医外治杂志，第13卷第4期. 2004 |
| 外用中医药制剂治疗烧伤的进展. 郭静，张毅.中医外治杂志，第13卷第4期. 2004 * |
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| CN101129787A (en) | 2008-02-27 |
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