CN102961601B - Traditional Chinese medicine mixture for promoting wound healing - Google Patents
Traditional Chinese medicine mixture for promoting wound healing Download PDFInfo
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- CN102961601B CN102961601B CN201210517809.2A CN201210517809A CN102961601B CN 102961601 B CN102961601 B CN 102961601B CN 201210517809 A CN201210517809 A CN 201210517809A CN 102961601 B CN102961601 B CN 102961601B
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Abstract
The invention provides a traditional Chinese medicine mixture for promoting wound healing. The traditional Chinese medicine mixture is prepared from raw medicines, namely, aconite, pinellia ternate, bletilla striata and musk; and the raw medicines are combined to generate a synergistic effect, so that the wound can be effectively promoted to heal. Compared with the prior art, the traditional Chinese medicine mixture has the advantages of being simple, convenient, experienced, low in price and less in side effect, can be used for treating both symptoms and root causes, is easily accepted by a patient and effectively treating cerebral arteriosclerosis, and is worthy of popularization and application in clinic.
Description
Technical field
The invention belongs to Chinese medicine technical field, be specifically related to a kind of Chinese medicine mixture of wound healing.
Background technology
Wound healing is surgery's important component part, and various wounds, burn, radiation injure the long-term clinical common thorny problem especially that do not heal of the wounds such as diabetes.The processes such as that the agglutination of wound, burns rear wound comprises is hemorrhage, inflammatory reaction, re-epithelialization, repair time is long; Flap coverage as early as possible, the healing of acceleration of wound face, is of great significance to clinical research.The clinical medicine for wound healing and method are more, as after performing the operation, use antibiotics, play the effect that suppresses wound infection, but have encouraged the Drug resistance of body, are unfavorable for the effect of Functional tissue Coordinated Play.Secondly, some ointments medicines, are used after wound, and skin absorbs slower, causes wound surface permeability bad, is easy to occur ulcer phenomenon.Therefore, oneself becomes one of tissue repair field difficult problem urgently to be resolved hurrily to promote skin trauma reparation, and the reparation of research skin wound healing has important theoretical and practical significance.
Summary of the invention
The research of Chinese medicine and pharmacy aspect wound healing has a long history, in Jin Daige flood < < Zhouhou Beiji Fang > >, with regard to Chinese medicines such as useful Folium Isatidiss, process the record that wound is healed its speed, clinical and experimentation is in recent years also in continuous trial; Therefore still there is demand to the Chinese medicine preparation of curative effect better healing wound face healing in the mankind, up to now, also do not find any report about pharmaceutical composition of the present invention, the inventor is through research repeatedly, finally the Chinese medicine preparation that has found the treatment wound face healing of better efficacy, has completed the present invention.The object of the invention is to provide a kind of using method simple and fast, and wound healing speed is accelerated, the Chinese medicine mixture that fungistatic effect is good.
Another object of the present invention is to provide the preparation method of above-mentioned Chinese medicine mixture.
The consumption of ingredients part of the present invention is that inventor gets through groping in a large number for a long time to sum up, and each component consumption all has good curative effect in following weight parts:
15～35 parts of Aconitum carmichjaelii Debx.s, 5～15 parts of the Rhizoma Pinelliaes, 5～15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 15～25 parts of Herba thymi vulgaris.
As preferred version, the Chinese medicine mixture of above-mentioned wound healing, each recipe ingredient by weight:
25 parts of Aconitum carmichjaelii Debx.s, 10 parts of the Rhizoma Pinelliaes, 10 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 20 parts of Herba thymi vulgaris.
The preparation method of the Chinese medicine mixture of above-mentioned wound healing: take each crude drug component in the ratio of above-mentioned formula, be fried into water preparation.
Medicament selection Aconitum carmichjaelii Debx. of the present invention, the Rhizoma Pinelliae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba thymi vulgaris combine, and make each efficacy of drugs produce synergism these drug regimens, thereby effectively promote wound face healing.Wherein Aconitum carmichjaelii Debx. acrid in the mouth, hot in nature, poisonous; GUIXIN, liver, spleen channel; Dispel the wind blood stasis dispelling, dispersing cold for relieving pain, cure mainly anemofrigid-damp arthralgia, numb limbs and tense tendons is ached.The Rhizoma Pinelliae is pungent, temperature; Poisonous.Return spleen, stomach, lung meridian; Drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass; Externally used detumescence pain relieving.Pseudobulbus Bletillae (Rhizoma Bletillae) bitter in the mouth, sweet, puckery, cold in nature; Return lung, stomach, Liver Channel; Have astringing to arrest bleeding, the merit of detumescence and promoting granulation, for all cards of interior external haemorrhage and carbuncle, scald, rhagadia manus et pedis, anal fissure etc.Herba thymi vulgaris property hardship, pungent, flat; Enter lung, large intestine two warps; Relieving cough and resolving phlegm, antiinflammatory, parasite killing.In tradition pharmacology, record: Aconitum carmichjaelii Debx., two kinds of same use of medicine of the Rhizoma Pinelliae, can there is violent side effect, be called contrary.In successive dynasties books on Chinese herbal medicine works, record 18 kinds of medicines contrary, can not compatibility, claim eighteen incompatible medicaments, the anti-Rhizoma Pinelliae of Aconitum carmichjaelii Debx. is in eighteen incompatible medicaments, to avoid one of medication.Forefathers mainly concentrate on application method (taking orally) and dosage the understanding of eighteen incompatible medicaments.
Since 2008, inventor's constraint that breaks traditions, is fried into mixture by Aconitum carmichjaelii Debx. and the Rhizoma Pinelliae, starts to attempt external, and inquires into its impact on wound healing.Through long-term research, find, this mixture can promote that wound face heals in advance, remarkable to trauma care effect, has brought convenience to patient's work and life.
Beneficial effect of the present invention: the present invention adopts external mode, adjusts using dosage and makes its collaborative performance curative effect, and compared with prior art, the present invention has thinking novelty, easy to use, has no side effect, and can more effectively promote wound face healing.
The specific embodiment
Below by test example, further set forth the beneficial effect of the Chinese medicine mixture of wound healing of the present invention, these test examples comprise the clinical observation on the therapeutic effect test of the Chinese medicine mixture of wound healing of the present invention.
Medicine major function of the present invention and therapeutic domain:
Major function:
Promote wound face healing.
Therapeutic domain:
Knife injury, surgical wound, mechanical presses wound, Physicochemical sexual trauma, inflammatory wound, ischemic wound and metabolic wound etc.
Usage and dosage:
Smear every day 3 times, with cotton swab, smear wound surface at every turn.
The therapeutical effect of the Chinese medicine mixture of [test example 1] wound healing of the present invention to wound surface
1. zoopery of the present invention
By new zealand white rabbit back depilation preserved skin, body weight 2.5-3.0kg, routine disinfection, in the middle part of animal back, spinal column both sides respectively cut off the holostrome skin of 2 diameter 2.0cm with surgical method, deeply reach sarolemma, cause 4 whole bark breaks to damage animal models.A wound is made as normal control, and a wound is removed into dexamethasone, a wound medicine of the present invention, a wound applied Wound plaster of yannan Baiyao.Every rabbit sub-cage rearing, respectively at after modeling 3,6,9d puts to death animal.After perusal wound the 3rd, 6,9d wound healing situation.
Result:
Postoperative 3d, it is all red and swollen, moistening that each processing factor is formed face, all occurs the infection signs such as limitation canescence thickness pus, and inflammatory reaction is strong, edge of wound depression, wound contraction is not obvious.Postoperative 6d, Chinese medicine preparation group and YUNNAN BAIYAO group wound are moistening, and without obvious pus, wound surface and subcutaneous tissue shrink obviously; And Dexamethasone group and Normal group still have and ooze out, still there is rare faint yellow thin pus, yellow-white organizes filling wherein; There is ulcer in the indivedual wounds of Dexamethasone group.Postoperative 9d, it is dry that Aconitum carmichjaelii Debx. Rhizoma Pinelliae mixture and YUNNAN BAIYAO are formed face, the thick crust of surface knot, under crust, granulation lovely luster, is graininess, and wound surface is obvious epithelization around, the expansion of the visible skin of some wound surface island, last wound surface is irregular; Dexamethasone group and the more postoperative 6d of Normal group wound area have obvious contraction, only edge incrustation of wound surface; It is still moistening that part dexamethasone is formed face.
The clinical observation of the Chinese medicine mixture of [test example 2] wound healing of the present invention
1, physical data
Accept patient's 80 examples for medical treatment, patient is divided into two groups at random, treatment group 50 examples, give Drug therapy of the present invention, and matched group 30 examples, have Drug therapy; Age minimum 4 with, maximum 63 years old, two groups of patients were in a basic balance aspect mean age, the course of disease, the state of an illness, have comparability.
Diagnostic criteria:
The diagnostic criteria of head, abdominal part, two lower limb wounds:
I。The stratum germinativum of the dark and epidermis of wound, papillary layer of corium, local red and swollen heat pain, without slough tissue, 10 days internal injury healing.
II。Dark and the dermal layer of the skin of wound, wound surface is kermesinus, pale asphyxia, and local red and swollen heat pain has 1/3 slough tissue not heal for 10 days.
III。Wound reaches subcutaneous tissue deeply and even, and wound surface is pale, has dense sexual secretion, and local red and swollen heat pain, has 2/3 slough tissue, not healing in 10 days.
IV。Wound dark and muscle and exposed bone, wound surface is pale, has dense sexual secretion, and local red and swollen heat pain is covered with slough tissue and does not heal in 10 days.
Therapeutic Method:
Therapeutic Method is under the voluntary prerequisite of patient, and patient is divided into two groups at random, and treatment group 50 examples are used medicine of the present invention, adopts smearing method, every day 5 times, smears wound surface, matched group 30 examples, conventional treatments.
The standard of curative effect evaluation:
Primary healing: tissue repair is take original cell as main with regard to a small amount of fibrous tissue, and the rapid structure function of Regeneration and Repair process recovers good, and cicatrix is less.
Secondary healing: take fibrous tissue reparation as main, fibrous tissue reparation is that the main 26S Proteasome Structure and Function that affects in various degree recovers, be more common in that degree of injury is heavy, scope is large, slough is many and often with infection, do not obtain rational early recovery, cicatrix is smooth, without obviously raised or cave in.
3,6,9d calculates wound healing rate: wound healing rate=(original wound surface area-wound surface area does not heal)/original wound surface area.
Carry out by the following examples further to set forth the Chinese medicine mixture of wound healing of the present invention.
The Chinese medicine mixture of wound healing of the present invention is to be made by the crude drug of following weight portion:
15～35 parts of Aconitum carmichjaelii Debx.s, 5～15 parts of the Rhizoma Pinelliaes, 5～15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 15～25 parts of Herba thymi vulgaris.
As preferred version, the Chinese medicine mixture of above-mentioned wound healing, each recipe ingredient by weight:
25 parts of Aconitum carmichjaelii Debx.s, 10 parts of the Rhizoma Pinelliaes, 10 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 20 parts of Herba thymi vulgaris.
The preparation method of the Chinese medicine mixture of above-mentioned wound healing: take each crude drug component in the ratio of above-mentioned formula, be fried into water preparation.
Its concrete preparation method is: by formula proportion, take each crude drug component, put into pot, add water not have powder to be advisable, under room temperature, will in medicine water, soak 24 hours, be placed on and on stove, be heated to water boiling, keep fluidized state 40 minutes, use filtered through gauze medicinal residues, stay water liquid, centrifugal, get supernatant, obtain described Chinese medicine mixture.
[embodiment 1]
The Chinese medicine mixture of wound healing of the present invention is to be made by the crude drug of following weight portion:
25 parts of Aconitum carmichjaelii Debx.s, 10 parts of the Rhizoma Pinelliaes, 10 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 20 parts of Herba thymi vulgaris.
The preparation method of the Chinese medicine mixture of wound healing of the present invention: take each crude drug component by formula proportion, put into pot, add water not have powder to be advisable, under room temperature, will in medicine water, soak 24 hours, be placed on and on stove, be heated to water boiling, keep fluidized state 40 minutes, use filtered through gauze medicinal residues, stay water liquid, centrifugal, get supernatant, obtain described Chinese medicine mixture.
[embodiment 2]:
The Chinese medicine mixture of wound healing of the present invention is to be made by the crude drug of following weight portion:
15 parts of Aconitum carmichjaelii Debx.s, 5 parts of the Rhizoma Pinelliaes, 5 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 15 parts of Herba thymi vulgaris.
Its preparation method is with embodiment 1.
[embodiment 3]:
The Chinese medicine mixture of wound healing of the present invention is to be made by the crude drug of following weight portion:
20 parts of Aconitum carmichjaelii Debx.s, 10 parts of the Rhizoma Pinelliaes, 10 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 20 parts of Herba thymi vulgaris.
Its preparation method is with embodiment 1.
[embodiment 4]:
The Chinese medicine mixture of wound healing of the present invention is to be made by the crude drug of following weight portion:
25 parts of Aconitum carmichjaelii Debx.s, 15 parts of the Rhizoma Pinelliaes, 15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 25 parts of Herba thymi vulgaris.
Its preparation method is: by formula proportion, take each recipe ingredient, be fried into water preparation, further make spray.
[embodiment 5]:
The Chinese medicine mixture of wound healing of the present invention is to be made by the crude drug of following weight portion:
30 parts of Aconitum carmichjaelii Debx.s, 15 parts of the Rhizoma Pinelliaes, 15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 25 parts of Herba thymi vulgaris.
Its preparation method is with embodiment 4.
[embodiment 6]:
The Chinese medicine mixture of wound healing of the present invention is to be made by the crude drug of following weight portion:
35 parts of Aconitum carmichjaelii Debx.s, 10 parts of the Rhizoma Pinelliaes, 5 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 15 parts of Herba thymi vulgaris.
Its preparation method is with embodiment 4.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, although the present invention is had been described in detail with reference to previous embodiment, for a person skilled in the art, its technical scheme that still can record aforementioned each embodiment is modified, or part technical characterictic is wherein equal to replacement.Within the spirit and principles in the present invention all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (3)
1. an external application Chinese medicine mixture for wound healing, the external application Chinese medicine mixture that it is characterized in that described wound healing is to be made by the crude drug of following weight portion:
15～35 parts of Aconitum carmichjaelii Debx.s, 5～15 parts of the Rhizoma Pinelliaes, 5～15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 15～25 parts of Herba thymi vulgaris.
2. the external application Chinese medicine mixture of wound healing according to claim 1, the external application Chinese medicine mixture that it is characterized in that described wound healing is to be made by the crude drug of following weight portion:
25 parts of Aconitum carmichjaelii Debx.s, 10 parts of the Rhizoma Pinelliaes, 10 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 20 parts of Herba thymi vulgaris.
3. the preparation method of the external application Chinese medicine mixture of a wound healing as claimed in claim 1 or 2, the preparation method that it is characterized in that this external application Chinese medicine mixture is: by formula proportion, take each crude drug component, put into pot, add water not have powder to be advisable, under room temperature, will in medicine water, soak 24 hours, be placed on stove and be heated to water boiling, keep fluidized state 40 minutes, use filtered through gauze medicinal residues, stay water liquid, centrifugal, get supernatant, obtain described Chinese medicine mixture.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210517809.2A CN102961601B (en) | 2012-12-06 | 2012-12-06 | Traditional Chinese medicine mixture for promoting wound healing |
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| CN201210517809.2A CN102961601B (en) | 2012-12-06 | 2012-12-06 | Traditional Chinese medicine mixture for promoting wound healing |
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| CN102961601A CN102961601A (en) | 2013-03-13 |
| CN102961601B true CN102961601B (en) | 2014-04-23 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1264538C (en) * | 2004-12-01 | 2006-07-19 | 陈立德 | Itching relieving medicament |
| CN100455280C (en) * | 2006-05-01 | 2009-01-28 | 杨树民 | An externally applied ointment |
| CN101152378B (en) * | 2007-09-26 | 2010-04-21 | 徐雪梅 | Externally used traditional Chinese medicine preparation for diminishing the inflammation and reducing the pain |
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2012
- 2012-12-06 CN CN201210517809.2A patent/CN102961601B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1264538C (en) * | 2004-12-01 | 2006-07-19 | 陈立德 | Itching relieving medicament |
| CN100455280C (en) * | 2006-05-01 | 2009-01-28 | 杨树民 | An externally applied ointment |
| CN101152378B (en) * | 2007-09-26 | 2010-04-21 | 徐雪梅 | Externally used traditional Chinese medicine preparation for diminishing the inflammation and reducing the pain |
Non-Patent Citations (2)
| Title |
|---|
| 梁栋蓉等.生肌膏治疗外伤性溃疡创面.《内蒙古医学杂志》.1999,第31卷(第3期),166. |
| 生肌膏治疗外伤性溃疡创面;梁栋蓉等;《内蒙古医学杂志》;19990331;第31卷(第3期);166 * |
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