Background technology
Rheumatic arthritis (rheumatoid arthritis) is a kind of common acute or chronic ICT, can show effect repeatedly and involves heart.Clinical miserable with joint and muscle the. fugitive, heavily work, pain is characteristic.Belong to allergic disease.Rheumatic arthritis has two characteristics: the one, and the joint is red, swollen, hot, pain is obvious, and stiff, site of pathological change usually is the big joints of lower limb such as knee joint, hip, ankle, secondly is shoulder, elbow, carpal joint, and brothers' little joint is rare; The 2nd, the pain migration is indefinite, and a period of time is this joint outbreak, and a period of time is that joint is uncomfortable, but durante dolors is not long, just can disappear in several days.
The traditional Chinese medical science thinks that pathogenic factor and pathogenic process have substantially: the heresy of diseases caused by exogenous pathogenic factor six climate exopathogens, and wind-cold damp pathogen impatency meridians and joint, stagnation of QI and blood may bring about pain is so cause joint swelling and pain.Ying-qi is defended the blood imbalance, disharmony of nutrient QI with defensive QI, and pathogen is taken advantage of a weak point, and causes the rheumatism outbreak.Internal organs negative and positive internal injury, negative and positive are uneven, inclined to one side Sheng occurs and decline partially, receive pathogen and invade, and rheumatismal heat and cold symptom performance take place.Give birth in the phlegm-turbidity and blood stasis blood, the pathogenic factor going from the exterior into the interior by light and weigh, cause visceral dysfunction, and the result of visceral dysfunction just produces the turbid and blood stasis of expectorant, and these are exactly the touching and basic reason of refractory of the rheumatism state of an illness.For rheumatic arthritis treatment, be divided into generally that Western medicine alleviates pain, the pain relieving of medicine for external use relaxing muscles and tendons and activating QI and blood in the collateral.As with bigcatkin willow acid supplement and on-steroidal preparation with alleviating pain, diminish inflammation the control active rheumatism.In medicinal dog skin plaster functions dispelling wind and clearing away cold, removing dampness, the relaxing muscles and tendons and activating QI and blood in the collateral pain relieving.Also has ZHUIFENG GAO etc. in addition.Since " curing the symptoms, not the disease ", and be prone to recurrence after the drug withdrawal, so the treatment of rheumatic arthritis it is generally acknowledged there is not specific drug.
Prevalence is high, and the relapse rate height is the main feature of rheumatic arthritis disease, reflects that simultaneously the demand in rheumatic arthritis disease therapeuticing medicine market is huge.Medicated wine occupies critical role in rheumatic arthritis disease medication market, because the medicated wine side effect is little, determined curative effect is applicable to long-term prescription; Adapted to the characteristics of rheumatic arthritis disease easy relapse, clinical practice is very extensive, though existing deer-blood wine is main component with the Sanguis cervi, and the Chinese crude drug that preparation quantity does not wait; Because compatibility is unreasonable, has influenced effect of drugs, Sanguis cervi solidifies easily, can not produce smoothly; The prescription that has is the medical material of kidney invigorating and YANG supporting entirely, is not suitable for most of people and uses, and the mouthfeel that has is poor; The price that also has is expensive partially, and what have exists function singleness, acts on single deficiency, it is applied receive certain influence.
Summary of the invention
Goal of the invention:, the object of the present invention is to provide a kind of sick Sanguis cervi medicated wine of rheumatic arthritis of treating in order to address the above problem.
Technical scheme: the objective of the invention is to realize through following scheme:
A kind of Sanguis cervi medicated wine that is used to treat rheumatic arthritis, its contained active component is prepared from the following raw materials in part by weight proportioning: Sanguis cervi 8-16 part, Cornu Cervi Pantotrichum 8-16 part, Os Cervi 8-16 part, Scorpio 4-8 part, Scolopendra 4-8 part, Radix Angelicae Sinensis 3-5 part, Zaocys 8-16 part, Rhizoma Chuanxiong 25-35 part, Radix Aconiti 8-16 part, Flos Carthami 4-8 part, Herba Ephedrae 3-7 part, Ramulus Cinnamomi 8-16 part, Radix Angelicae Pubescentis 8-16 part, Radix Achyranthis Bidentatae 8-16 part, 3.8% liquor sodii citratis 8-16 part, 30 ° of-50 ° of Chinese liquor 800-2400 parts.
A kind of medicated wine that is used to treat rheumatic arthritis, its contained active component is prepared from the following raw materials in part by weight proportioning: 12 parts of Sanguis cervi, 12 parts in Cornu Cervi Pantotrichum, 12 parts of Os Cervi, 6 parts of Scorpios, 6 parts of Scolopendras, 4 parts of Radix Angelicae Sinensis, 12 parts of Zaocyss, 30 parts of Rhizoma Chuanxiongs, 12 parts of Radix Aconitis, 6 parts on Flos Carthami, 5 parts in Herba Ephedrae, 12 parts of Ramulus Cinnamomi, 12 parts of Radix Angelicae Pubescentiss, 12 parts of Radix Achyranthis Bidentataes, 1600 parts of 12 parts, 40 ° Chinese liquor of 3.8% liquor sodii citratis.
The above-mentioned method that is used to treat the Sanguis cervi medicated wine of rheumatic arthritis; Preparation process is: Sanguis cervi, Cornu Cervi Pantotrichum, Os Cervi, Scorpio, Scolopendra, Radix Angelicae Sinensis, Zaocys, Rhizoma Chuanxiong, Radix Aconiti, Flos Carthami, Herba Ephedrae, Ramulus Cinnamomi, Radix Angelicae Pubescentis, the Radix Achyranthis Bidentatae medical material of getting recipe quantity; Wherein Sanguis cervi uses the 3.8% liquor sodii citratis dissolving of equal volume amounts, and all the other medical material remove impurity, pulverizing are excessively behind 60 mesh sieves; Put into 30 ° of-50 ° of Chinese liquor together with Sanguis cervi solution and soaked 10-20 days, the elimination medicinal residues promptly get medicated wine.
The above-mentioned Sanguis cervi medicated wine that is used to treat rheumatic arthritis; Sanguis cervi is the blood of animal in deer family Cervus nippon Temminck Cervus nippon Temminck; Cornu Cervi Pantotrichum is the young horn of the unossified close living fine hair of stag of animal in deer family Cervus nippon Temminck Cervus nippon Temminck, and Os Cervi is the skeleton of animal in deer family Cervus nippon Temminck Cervus nippon Temminck.
The above-mentioned Sanguis cervi medicated wine that is used to treat rheumatic arthritis; Sanguis cervi is the blood of animal in deer family Cervus elaphus linnaeus Cervus elaphus Linnaeus; Cornu Cervi Pantotrichum is the young horn of the unossified close living fine hair of stag of animal in deer family Cervus elaphus linnaeus Cervus elaphus Linnaeus, and Os Cervi is the skeleton of animal in deer family Cervus elaphus linnaeus Cervus elaphus Linnaeus.
Chinese crude drug of the present invention is the pharmacopeia kind.
Beneficial effect:
1, see from theory of Chinese medical science, Sanguis cervi, Cornu Cervi Pantotrichum, Os Cervi kidney invigorating and YANG supporting among the we, with szechuan lovage rhizome and safflower blood circulation promoting and blood stasis dispelling, Radix Achyranthis Bidentatae wind-expelling pain-stopping, Radix Aconiti, Radix Angelicae Pubescentis expelling wind and removing dampness; Removing obstruction in the collateral to relieve pain, eight is monarch drug, Scorpio, Scolopendra endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain; Zaocys dispels the wind, collateral dredging, and relieving convulsion, the three is a ministerial drug, the merit of principal drug assistance collateral dredging; Chinese angelica blood supplementing is invigorated blood circulation, menstruction regulating and pain relieving, Herba Ephedrae, Ramulus Cinnamomi diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema; The three is adjuvant altogether, and all medicines are harmonious, and play the wind-expelling pain-stopping effect altogether, are used to treat the rheumatic arthritis disease.
2, the present invention writes out a prescription reasonable in designly, and compatibility is rigorous, and Sanguis cervi did not solidify before adding Chinese liquor, helped big production operation, through secular clinical verification, determined curative effect.
3, the present invention consists of Chinese crude drug, has no side effect low price.
The specific embodiment
Below through the embodiment form; Foregoing of the present invention is remake further detailed description; But should this be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following instance, all technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
1, preparation embodiment
Embodiment 1: get 8 parts of Flos Mume Sanguis cervi, 16 parts of sika deer velvet antlers, 8 parts of Flos Mume Os Cervi, 8 parts of Scorpios, 4 parts of Scolopendras, 5 parts of Radix Angelicae Sinensis, 8 parts of Zaocyss, 35 parts of Rhizoma Chuanxiongs, 8 parts of Radix Aconitis, 8 parts on Flos Carthami, 3 parts in Herba Ephedrae, 16 parts of Ramulus Cinnamomi, 8 parts of Radix Angelicae Pubescentiss, 16 parts of medical materials of Radix Achyranthis Bidentatae; Sanguis cervi uses the 3.8% liquor sodii citratis dissolving of equal volume amounts; All the other medical material remove impurity, pulverizing; Cross behind 60 mesh sieves and Sanguis cervi solution is put into 30 ° of Chinese liquor (800 parts) together and soaked 10 days, the elimination medicinal residues promptly get medicated wine.
Embodiment 2: get 12 parts of Flos Mume Sanguis cervi, 12 parts of sika deer velvet antlers, 12 parts of Flos Mume Os Cervi, 6 parts of Scorpios, 6 parts of Scolopendras, 4 parts of Radix Angelicae Sinensis, 12 parts of Zaocyss, 30 parts of Rhizoma Chuanxiongs, 12 parts of Radix Aconitis, 6 parts on Flos Carthami, 5 parts in Herba Ephedrae, 12 parts of Ramulus Cinnamomi, 12 parts of Radix Angelicae Pubescentiss, 12 parts of medical materials of Radix Achyranthis Bidentatae; Sanguis cervi uses the 3.8% liquor sodii citratis dissolving of equal volume amounts; All the other medical material remove impurity, pulverizing; Cross behind 60 mesh sieves and Sanguis cervi solution is put into 40 ° of Chinese liquor (1600 parts) together and soaked 15 days, the elimination medicinal residues promptly get medicated wine.
Embodiment 3: get 16 parts of Flos Mume Sanguis cervi, 8 parts of sika deer velvet antlers, 16 parts of Flos Mume Os Cervi, 4 parts of Scorpios, 8 parts of Scolopendras, 3 parts of Radix Angelicae Sinensis, 16 parts of Zaocyss, 25 parts of Rhizoma Chuanxiongs, 16 parts of Radix Aconitis, 4 parts on Flos Carthami, 7 parts in Herba Ephedrae, 8 parts of Ramulus Cinnamomi, 16 parts of Radix Angelicae Pubescentiss, 8 parts of medical materials of Radix Achyranthis Bidentatae; Sanguis cervi uses the 3.8% liquor sodii citratis dissolving of equal volume amounts; All the other medical material remove impurity, pulverizing; Cross behind 60 mesh sieves and Sanguis cervi solution is put into 50 ° of Chinese liquor (2400 parts) together and soaked 20 days, the elimination medicinal residues promptly get medicated wine.
Embodiment 4: get 8 parts of Cervus Elaphus bloods, 16 parts of cervus elaphus linnaeuss, 8 parts of Cervus elaphus Linnaeas bone, 8 parts of Scorpios, 4 parts of Scolopendras, 5 parts of Radix Angelicae Sinensis, 8 parts of Zaocyss, 35 parts of Rhizoma Chuanxiongs, 8 parts of Radix Aconitis, 8 parts on Flos Carthami, 3 parts in Herba Ephedrae, 16 parts of Ramulus Cinnamomi, 8 parts of Radix Angelicae Pubescentiss, 16 parts of medical materials of Radix Achyranthis Bidentatae; Sanguis cervi uses the 3.8% liquor sodii citratis dissolving of equal volume amounts; All the other medical material remove impurity, pulverizing; Cross behind 60 mesh sieves and Sanguis cervi solution is put into 30 ° of Chinese liquor (800 parts) together and soaked 10 days, the elimination medicinal residues promptly get medicated wine.
Embodiment 5: get 12 parts of Cervus Elaphus bloods, 12 parts of cervus elaphus linnaeuss, 12 parts of Cervus elaphus Linnaeas bone, 6 parts of Scorpios, 6 parts of Scolopendras, 4 parts of Radix Angelicae Sinensis, 12 parts of Zaocyss, 30 parts of Rhizoma Chuanxiongs, 12 parts of Radix Aconitis, 6 parts on Flos Carthami, 5 parts in Herba Ephedrae, 12 parts of Ramulus Cinnamomi, 12 parts of Radix Angelicae Pubescentiss, 12 parts of medical materials of Radix Achyranthis Bidentatae; Sanguis cervi uses the 3.8% liquor sodii citratis dissolving of equal volume amounts; All the other medical material remove impurity, pulverizing; Cross behind 60 mesh sieves and Sanguis cervi solution is put into 40 ° of Chinese liquor (1600 parts) together and soaked 15 days, the elimination medicinal residues promptly get medicated wine.
Embodiment 6: get 16 parts of Cervus Elaphus bloods, 8 parts of cervus elaphus linnaeuss, 16 parts of Cervus elaphus Linnaeas bone, 4 parts of Scorpios, 8 parts of Scolopendras, 3 parts of Radix Angelicae Sinensis, 16 parts of Zaocyss, 25 parts of Rhizoma Chuanxiongs, 16 parts of Radix Aconitis, 4 parts on Flos Carthami, 7 parts in Herba Ephedrae, 8 parts of Ramulus Cinnamomi, 16 parts of Radix Angelicae Pubescentiss, 8 parts of medical materials of Radix Achyranthis Bidentatae; Sanguis cervi uses the 3.8% liquor sodii citratis dissolving of equal volume amounts; All the other medical material remove impurity, pulverizing; Cross behind 60 mesh sieves and Sanguis cervi solution is put into 50 ° of Chinese liquor (2400 parts) together and soaked 20 days, the elimination medicinal residues promptly get medicated wine.
3. clinical observation material
Sample preparation: get 12 parts of Flos Mume Sanguis cervi, 12 parts of sika deer velvet antlers, 12 parts of Flos Mume Os Cervi, 6 parts of Scorpios, 6 parts of Scolopendras, 4 parts of Radix Angelicae Sinensis, 12 parts of Zaocyss, 30 parts of Rhizoma Chuanxiongs, 12 parts of Radix Aconitis, 6 parts on Flos Carthami, 5 parts in Herba Ephedrae, 12 parts of Ramulus Cinnamomi, 12 parts of Radix Angelicae Pubescentiss, 12 parts of medical materials of Radix Achyranthis Bidentatae; Sanguis cervi uses the 3.8% liquor sodii citratis dissolving of equal volume amounts; All the other medical material remove impurity, pulverizing; Cross behind 60 mesh sieves and Sanguis cervi solution is put into 40 ° of Chinese liquor (1600 parts) together and soaked 15 days, the elimination medicinal residues promptly get medicated wine.
The inventor is to 100 routine cases (test group 60 examples, matched group 40 examples) clinical observation, wherein, male 55 examples, women 45 examples, at minimum 48 years old of age, maximum 75 years old, the course of disease was the longest 14 years, the shortest person half a year, average 5 years.The case selection is diagnosed as the patient of rheumatic arthritis according to symptom and examination in hospital.Wherein, test group 60 examples comprise male 40 examples, women 20 examples, and at minimum 48 years old of age, maximum 75 years old, the course of disease was the longest 13 years, the shortest person half a year, average 7.1 years.Matched group 40 examples comprise male 20 examples, women 20 examples, and at minimum 58 years old of age, maximum 68 years old, the course of disease was the longest 14 years, the shortest person half a year, average 4.7 years.The course of disease of two groups of cases, degrees of symptoms etc., comprehensive average back there was no significant difference has comparability between each group.
Test group adopts the present invention's Sanguis cervi medicated wine to treat, and during treatment, administrated method is: take every day 3 times, early, middle and late each once, a 20mL, period in a medicine fasting raw food raw meat food serve on 2 months.Matched group gives homemade ibuprofen 0.4g oral, every day three times, serve on 2 months.
Two groups of cases all the 1st week, the 2nd week, the 1st month, the 2nd month are observed cardinal symptom and sign after medication.
The criterion of curative effect, the percentage scoring method that adopts Huskisson to propose, i.e. visual simulation pain scale (VAPS) is promptly used 100 millimeters straight lines, and an end is painless, and the other end is for the most painful.The same time of regular ten these days of patient marks the degree of pain on line.In conjunction with clinical practice, curative effect is divided basic healing, produce effects, effective and invalid.The concrete standard of curative effect is following:
The basic healing: pain symptom disappears, and VAPS is less than 20;
Produce effects: pain symptom obviously alleviates, and VAPS is between 20-50;
Effectively: pain symptom alleviates, and VAPS is between 21-50;
Invalid: pain symptom alleviates little obvious, and VAPS is more than 80.
Curative effect situation catalog
Group |
The basic healing |
Produce effects |
Effectively |
Invalid |
Total effective rate |
Test group |
34 |
13 |
8 |
5 |
91.67% |
Matched group |
15 |
10 |
5 |
10 |
75.00% |
Can find out that from last table the total effective rate of test group is 91.67, the total effective rate of matched group is 75.00%.The effective percentage of test group has been compared positive effect with matched group.The cure rate of test group is 56.67%, and the cure rate of matched group is 37.5%.The cure rate of test group has been compared the significance effect with matched group.Healing case in the test group was paid a return visit respectively after half a year, 1 year, did not all have recurrence.In sum, the therapeutic effect of the medicine of wood invention obviously is superior to matched group.
4. model case
Case 1: the flood certain, woman 49 years old.Bone joint, coxarthropathy are very met the cold rnning play when examining, and morning, time-out pain increased the weight of, and limb activity is dumb.Chemical examination: erythrocyte sedimentation rate 45mm/h, X line show no sclerotin change, and feeling of numbness alleviates, and takes wooden inventive embodiments 2 Sanguis cervi medicated wine, symptom complete obiteration after three months, joint motion freely, erythrocyte sedimentation rate 16mm/h follows up a case by regular visits to so far and recurs.
Case 2: chapter, man 54 years old.The whole body arthralgia was shown effect 6 years repeatedly, and limbs are heavy, and rise stiff morning, the joint joint stuffiness.Chemical examination: erythrocyte sedimentation rate 52mm/h, rheumatoid factor negative.Clinical diagnosis is a rheumatic arthritis, and it is sick that card belongs to cold warm numbness.With taking the embodiment of the invention 2 Sanguis cervi medicated wine, after 40 days, arthralgia alleviates, adhere to medication 2 wheat harvesting periods continuously after, all diseases of arthralgia disappear, functional rehabilitation, laboratory indexes are all normal.
Case 3: husky certain, man 68 years old.Suffered from rheumatoid arthritis 20 years, extremities joint swells and ache, and restriction of neck motion is very painful.Through examination in hospital, erythrocyte sedimentation rate 70mm/h, rheumatoid factor positive (+) is taken hormone for a long time; Medicines such as analgesia sheet, walking function obstacle, agonizing is taken the embodiment of the invention 2 Sanguis cervi medicated wine treatment three months; Symptom obviously alleviates, and treats again two months, and erythrocyte sedimentation rate, rheumatoid factor recover normal; Arthralgia takes a turn for the better, and patients clinical is cured, and follows up a case by regular visits to and does not see recurrence in 2 years.