CN1264538C

CN1264538C - Itching relieving medicament

Info

Publication number: CN1264538C
Application number: CNB2004101010026A
Authority: CN
Inventors: 陈立德
Original assignee: Individual
Current assignee: Individual
Priority date: 2004-12-01
Filing date: 2004-12-01
Publication date: 2006-07-19
Anticipated expiration: 2024-12-01
Also published as: CN1650995A

Abstract

The present invention relates to an antipruritic drug and an antipruritic medicinal composition, particularly to an antipruritic drug prepared from natural perfume and allantoin as main raw materials. The present invention provides a hormone-free antipruritic drug which has fine antipruritic effect and particularly has a special effect on itch caused by wound incrustation and child miliaria. The drug comprises 2 to 22% of medicinal oil, 0.5 to 10% of allantoin and the balance of matrix, wherein the medicinal oil has 1 to 5% of menthol, 1 to 8% of camphor, 0 to 3% of thymol, 0 to 2% of borneol and 0 to 4% of wintergreen oil. The drug has antipruritic effect; because the allantoin is not a hormone, the allantoin can be used for the skin in a relatively large area, and the allantoin serves as skin consolidant, has local anaesthetic effect, benefits epithelial hyperplasia, promotes the growth of granulation tissue and the healing of wounds, and benefits the incrustation of wounds with itches. The drug has the advantages of strong skin adhesion, persistent drug effect and favourable miliaria eliminating effect, and is used for treating chilblain without ulcers.

Description

A kind of antipruritic agent

Technical field

The present invention relates to a kind of itching relieving pharmaceutical composition, especially relating to a kind of is the antipruritic agent that primary raw material is made with natural perfume material and allantoin.

Background technology

Dermatosis is a kind of commonly encountered diseases, and especially various pruritus cause suffering and discomfort to patient.Existing for this reason multiple itching relieving medicine.Sanjiu Pharmaceutical Co., Ltd's Piyanping ointment (existing) of producing for example with compound dexamethason acetate emulsifiable paste by name, it is mainly used in anaphylaxis and autoimmune inflammation disease, as local pruritus, neurodermatitis etc.; Its primary raw material is dexamethasone acetate 0.075%, Camphora 1%, Mentholum 1%, and substrate adds to 100%.The disclosed WUJI GAO prescription of the Sanitation Ministry medicine standard is Herba Menthae 3.5%, Borneolum Syntheticum 0.5%, thymol 0.25%, Camphora 5.6%, wintergreen oil 3%, beclometasone 0.05%, and all the other add to 100% for substrate.The patent No. is 931033624 patent " a kind of treatment dermatosis external-application cream commonly used and manufacture method thereof ", its raw material is antifungal agent 0.5%～3%, beclometasone 0.005%～0.05%, azone 0.5%～2%, the medicine oil 5%～25% of azole derivative, substrate adds to 100%, its Chinese medicine oil composition is Mentholum 1%～5%, thymol 0.1%～6%, Borneolum Syntheticum 0.1%～6%, Camphora 0.1%～6%, methyl salicylate 1%～7%, is mainly used in dermatosiss such as neurodermatitis, insect dermatitis and papular urticaria.Though above medicine has itching-relieving action, there is following shortcoming, the one, contain hormone dexamethasone acetate/beclometasone etc., large tracts of land is used for a long time, especially is not suitable for the child and uses; The 2nd, very itching of wound incrustation do not illustrated therapeutic effect, especially generally need large tracts of land to use at very itching of wound incrustation, market does not see that any antipruritic agent can use safely and be treated so far.

Summary of the invention

The present invention aims to provide a kind of hormone that do not contain, and antipruritic effect is good, and what especially incrustation caused to wound very itches and the specific antipruritic agent of child's miliaria.

The present invention is the medicament of being made by following quality proportion raw material:

Medicine oil 2%～22%, allantoin 0.5%～10%, substrate adds to 100%, preferred medicine oil 12%～18%, allantoin 3%～6%.Its Chinese medicine oil is made up of following quality proportion raw material: Mentholum 1%～5%, Camphora 1%～8%, thymol 0～3%, Borneolum Syntheticum 0～2%, wintergreen oil are 0～4%, preferred Mentholum 2%～3%, Camphora 3%～5%, thymol 1～2%, Borneolum Syntheticum 0.5～1%, wintergreen oil are 1～2.5%.

At least a unguentum of making or gel in oil-in-water type ointment in the optional certainly existing technology of substrate, water-in-oil type ointment, vaseline, the high polymer etc.Said high polymer is selected different molecular weight polyethylene glycol etc. for use.

The present invention is a topical agent, is preferably unguentum.Its using method is to get an amount of medicament according to the area of wound and symptom to smear or dab the affected part, and every day 3～4 times, general wound 1～2 week of incrustation is a course of treatment, and miliaria is a course of treatment with 1 week.

During manufacturing, raw material is divided into water (for example glycerol, water, sodium hydroxide, potassium hydroxide), oil phase (octadecanol, stearic acid, monoglyceride, vaseline) and medicine oil (Mentholum, Camphora, thymol, Borneolum Syntheticum, wintergreen oil), in kettle internal heating to 60～100 ℃, oil phase is heated to 60～100 ℃ in oil cauldron water and allantoin, medicine oil stirs and dissolves each other, again with after water and the oil phase mixing and stirring, add the oil that is used as medicine and continue mixing and stirring emulsifying, to be cooledly get final product to room temperature.

The existing antipruritic agent overwhelming majority with better curative effect contains hormone (adrenal gland's skin hormone), and for example dexamethasone acetate, beclometasone, Clobetasol Propionate, triamcinolone acetonide, fluocinolone acetonide, hydrocortisone butyrate or oxygen fluorine are relaxed and comfortable etc.As everyone knows, the side effect of hormone is conspicuous, and long-term external hormone atrophoderma, telangiectasis, pigmentation can obviously occur, bring out untoward reaction such as infection.If at face's life-time service, symptoms such as facial skin flushing, telangiectasis, Perioral Dermatitis, acne rosacea sample skin lesion then can appear.Long-term large-area use can be because of being absorbed into the infringement that causes in the body health, for example hypertension, diabetes, hydrability ulcer and Cushing's syndrome etc.

The present invention not only has the itching-relieving action of existing similarly treatment dermatosis treating medicine, and because allantoin is not a hormone, can skin than large tracts of land on use, allantoin has the local anesthesia effect again originally as the skin healing agent, helps epithelial proliferation, promote granulation tissue growth and the healing of wound mouth, therefore help on the one hand often forming a scab, be unlikely the infection of scratching, help the wound decrustation with the wound of the phenomenon of very itching; On the other hand because of the strong adhesion of medicine to skin, lasting medicine, the miliaria of dispelling is effective, and can be used for treating nonulceration chilblain.

The specific embodiment

Embodiment 1: choose following raw material: Mentholum 1g, Camphora 1g, allantoin 5g, and substrate adopts oil-in-water type, and water is glycerol 10g, sodium hydroxide 0.2g, potassium hydroxide 0.1g; Oil phase is octadecanol 3g, stearic acid 4g, monoglyceride 1g, vaseline 2g.Earlier with water raw material glycerol, sodium hydroxide, potassium hydroxide and allantoin in kettle internal heating to 60～100 ℃, oil phase raw material octadecanol, stearic acid, monoglyceride, vaseline are heated to 60～100 ℃ in oil cauldron, medicine oil raw material stirring is dissolved each other, again with after water and the oil phase mixing and stirring, add the oil that is used as medicine and continue mixing and stirring emulsifying, the antipruritic cream that promptly obtains putty-type to room temperature to be cooled.Wherein the water that adds at aqueous phase is that 100g exceeds with the medicine total amount.

Embodiment 2: similar to Example 1, its main distinction is that the raw material of choosing is: Mentholum 2g, Camphora 1.5g, allantoin 0.5g, Borneolum Syntheticum 0.5g, wintergreen oil 0.5g.

Embodiment 3: similar to Example 1, its main distinction is that the raw material of choosing is: Mentholum 3g, Camphora 2g, allantoin 1g, thymol 1g, Borneolum Syntheticum 1g, wintergreen oil 1g.

Embodiment 4: similar to Example 1, its main distinction is that the raw material of choosing is: Mentholum 5g, Camphora 3g, allantoin 2g, thymol 2g.

Embodiment 5: similar to Example 1, its main distinction is that the raw material of choosing is: Mentholum 3g, Camphora 6g, allantoin 10g, Borneolum Syntheticum 5g.

Embodiment 6: similar to Example 1, its main distinction is that the raw material of choosing is: Mentholum 4g, Camphora 6g, allantoin 7g, thymol 3g, Borneolum Syntheticum 2g.

Embodiment 7: similar to Example 1, its main distinction is that the raw material of choosing is: Mentholum 3g, Camphora 8g, allantoin 6g, thymol 3g, wintergreen oil 3g.Substrate adopts water-in-oil type, and it is 100g that octadecanol 20g, hard ester acid 6g, vaseline 20g, Polyethylene Glycol (1000) 3g, water add to total amount.

Embodiment 8: similar to Example 7, its main distinction is that the raw material of choosing is: Mentholum 5g, Camphora 7g, allantoin 4g, thymol 2g, Borneolum Syntheticum 2g, wintergreen oil 4g.

Case 1: Wu, man, 36 years old.Because of being scalded the back of the hand by boiled water because of carelessness, after a couple of days, the wound healing incrustation is slept and wake up midnight in evening, feels that incrustation place of the back of the hand wound very itches, and feels ice-cold antipruritic immediately after smearing this medicine, goes to sleep peacefully, and smears medicine every day about 3～4 times.Decrustation after 4 days, wound healing, preventing from scar.

Case 2: Chen, man, 42 years old.Stroll in one day by the motorcycle shank of wounding, is added medicine to hospital, binds up a wound, and after 3 days, though wound need not add medicine to, wrap up, blackout forms a scab.Time sense incrustation place is very itched, and feels more and feels bad, and promptly smears this medicine and locates around incrustation, and sensation is lasting ice-cold antipruritic, after 3 days, and decrustation.

Case 3: Wang, man, 10 years old, students.Because of playing football, fall down that the left hand arm is injured bleeds, through medicine-feeding, wrap up after 4 days, forming a scab appears in wound, and child feels to itch, and can't forbid grabbing with hands, causes the hemorrhage once more infection of wound, have to add medicine to again.After 2 days, wound is formed a scab again, smear this medicament after, do not find the wound phenomenon of scratching again, decrustation after 3 days.

Case 4: Lee, woman, 50 years old.Careless knife injury, after the medication, the firm healing of wound is very itched, and hands commonly used scratches, and wound can not all be healed in many days, smears the decrustation of fully recovering after 3 days with this medicine.

Case 5: Lin, man, 3 years old.Because of hyperhidrosis, it is damp and hot, and the upper height miliaria was used floral water because of very itching, and poor effect is used a small amount of this medicament instead and gently smeared, miliaria recovery from illness after 2 days.

Case 6: land, woman, 65 years old.Get chilblains because of the cold xerosis cutis in sky, wrinkled skin is very itched, life-time service various medicaments, poor effect.After using this medicament, take a turn for the better gradually, medication was almost recovered after 10 days.

Claims

1, a kind of antipruritic agent is characterized in that it being the medicament of being made by following quality proportion raw material:

Medicine oil 2%～22%, allantoin 0.5%～10%, substrate adds to 100%, and its Chinese medicine oil is made up of following quality proportion raw material: Mentholum 1%～5%, Camphora 1%～8%, thymol 0～3%, Borneolum Syntheticum 0～2%, wintergreen oil are 0～4%.

2, a kind of antipruritic agent as claimed in claim 1 is characterized in that the medicament of being made by following quality proportion raw material:

Medicine oil 12%～18%, allantoin 3%～6%, substrate adds to 100%.

3, a kind of antipruritic agent as claimed in claim 1 is characterized in that said medicine oil is made up of following quality proportion raw material: Mentholum 2%～3%, and Camphora 3%～5%, thymol 1～2%, Borneolum Syntheticum 0.5～1%, wintergreen oil are 1～2.5%.

4, a kind of antipruritic agent as claimed in claim 1 is characterized in that said substrate is selected from least a unguentum of making or the gel in oil-in-water type ointment, water-in-oil type ointment, vaseline, the high polymer.

5, a kind of antipruritic agent as claimed in claim 4 is characterized in that said high polymer selects different molecular weight polyethylene glycol for use.