CN104490976A - Compound comfrey itching relieving eczema treatment drug - Google Patents
Compound comfrey itching relieving eczema treatment drug Download PDFInfo
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- CN104490976A CN104490976A CN201510016009.6A CN201510016009A CN104490976A CN 104490976 A CN104490976 A CN 104490976A CN 201510016009 A CN201510016009 A CN 201510016009A CN 104490976 A CN104490976 A CN 104490976A
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Abstract
A compound comfrey itching relieving eczema treatment drug relates to itching relieving pharmaceutical compositions. The compound comfrey itching relieving eczema treatment drug comprises raw materials of, by mass percentage, 0.1% to 5% of comfrey extract, 2% to 22% of medicated oil, 0.5% to 10% of allantoin and 100% of matrix. The medicated oil comprises raw materials of, by mass ratio, 2-3 of menthol, 1-2 of thymol, 0.5-1 of borneol, 1-2.5 of wintergreen oil and 2-5 of paeonol. The compound comfrey itching relieving eczema treatment drug is prepared by dividing the raw materials into water phases (glycerol, water, sodium hydroxide and potassium hydroxide), oil phases (octadecanol, stearic acid, monoglyceride and vaseline) and medicated oil (menthol, thymol, borneol, wintergreen oil and paeonol), heating the water phases and allantoin in to 60 DEG C to 100 DEG C in a pot with water, heating the oil phases to 60 DEG C to 100 DEG C in a pot with oil, stirring the medicated oil for solving, mixing and stirring the water phases with the oil phases uniformly, adding the medicated oil, mixing and stirring uniformly for emulsification and cooling to room temperature.
Description
Technical field
The present invention relates to a kind of antipruritic pharmaceutical composition, especially relate to the antipruritic eczema medicine of a kind of compound recipe Radix Arnebiae (Radix Lithospermi).
Background technology
Eczema is a kind of common skin diseases, causes suffering especially to the virgin developmental process of baby, bears at heart greatly to the head of a family.The existing medicine by Radix Arnebiae (Radix Lithospermi) treatment eczema for this reason, such as, " ZICAO YINGER RUANGAO " (accurate word B20020592 of traditional Chinese medicines) that Xiongye Pharmaceutical Industry Co., Ltd., Yunnan produces, it is mainly used in infantile eczema (diaper rash) treatment, its main component is arnebia root bark Flos Carthami, should " ZICAO YINGER RUANGAO " be ratified by state food drug surveilance office, though effective to infantile eczema, but obviously there is its weak point, one is that its composition is labeled as arnebia root bark, but its principal agent composition is indefinite, and composition is smudgy, is unfavorable for that target level of product quality controls; Two is that this product does not have itching-relieving action.As everyone knows, skin eczema can with skin pruritus, and poor for the virgin self-restraint of baby, one has skin to itch, and often scratches with a sudden impulse, and then scratches skin, brings out and infects and increase the weight of the state of an illness.
Chinese patent CN1872128 discloses a kind of gel for the treatment of diaper rash and preparation method thereof.The crude drug composition making this gel effective ingredient is by weight: Radix Arnebiae (Radix Lithospermi) 10 ~ 30 parts of Flos Carthami 10 ~ 30 parts.In order to obtain better curative effect, its adjuvant has: Acritamer 940 10 ~ 20 parts, dimethicone 40 ~ 60 parts, ethyl hydroxybenzoate 1 ~ 5 part, disodiumedetate 0.5 ~ 1 part, sodium bicarbonate 10 ~ 100 parts and purified water 750 ~ 920 parts.This invention has blood circulation promoting and blood stasis dispelling, the effect of removing pathogenic heat from blood and toxic substance from the body, and add the skin moistening of adjuvant, infiltration effect, its consumption is few, evident in efficacy, not pollution clothes, good patient compliance, very suitable to diaper rash medicine.
Summary of the invention
The object of the present invention is to provide containing Radix Arnebiae (Radix Lithospermi), the antipruritic eczema medicine of a kind of compound recipe Radix Arnebiae (Radix Lithospermi) that the effect with treatment eczema also can be antipruritic.
The present invention's raw material by mass percentage consists of: Radix Arnebiae extract 0.1% ~ 5%, medicine oil 2% ~ 22%, allantoin 0.5% ~ 10%, substrate adds to 100%.Preferred Radix Arnebiae extract 2% ~ 5%, medicine oil 5% ~ 15%, allantoin 5% ~ 10%, substrate adds to 100%.
Alkannin content by mass percentage >=30% in described Radix Arnebiae extract.
No. CAS of Radix Arnebiae extract is 517-89-5.
Described Radix Arnebiae extract extracts from Radix Arnebiae (Radix Lithospermi) and obtains, and is now commercial prod, domestic existing numerous manufacturer.
Described medicine oil raw material composition in mass ratio: Mentholum 2 ~ 3, thymol 1 ~ 2, Borneolum Syntheticum 0.5 ~ 1, wintergreen oil are 1 ~ 2.5, paeonol 2 ~ 5; Preferred Mentholum 2 ~ 2.5, thymol 1 ~ 1.5, Borneolum Syntheticum 0.5 ~ 0.8, wintergreen oil are 1 ~ 1.5, paeonol 2 ~ 4.
The unguentum that described substrate can adopt at least one in oil-in-water type ointment, water-in-oil type ointment, vaseline, high polymer etc. to make or gel.Described high polymer can select the Polyethylene Glycol etc. of different molecular weight.
The antipruritic eczema medicine of described compound recipe Radix Arnebiae (Radix Lithospermi) adopts following methods preparation:
Raw material is divided into aqueous phase (such as glycerol, water, sodium hydroxide, potassium hydroxide), oil phase (octadecanol, stearic acid, monoglyceride, vaseline) and medicine oil (Mentholum, thymol, Borneolum Syntheticum, wintergreen oil, paeonol), aqueous phase and allantoin are heated to 60 ~ 100 DEG C in kettle, oil phase is heated to 60 ~ 100 DEG C in oil cauldron, medicine oil stirs and dissolves each other, again by after aqueous phase and oil phase mixing and stirring, add the oil that is used as medicine and continue mixing and stirring emulsifying, to be cooled to room temperature.
The present invention is topical agent, is preferably unguentum.Its using method first cleans affected part, then get proper amount of medication and be applied to affected part, massage a moment, helps it to permeate, every day 2 ~ 3 times.
Instant invention overcomes " ZICAO YINGER RUANGAO " (traditional Chinese medicines accurate word B20020592) and the shortcoming existing for the existing antipruritic agent with good therapeutic effect of Xiongye Pharmaceutical Industry Co., Ltd., Yunnan's production, such as: the principal agent composition that " ZICAO YINGER RUANGAO " exists is indefinite, does not have the shortcomings such as itching-relieving action.The existing antipruritic agent with good therapeutic effect is ubiquitous containing hormone (adrenal gland's skin hormone), and long-term external hormone, obviously can occur atrophoderma, telangiectasis, pigmentation, bring out the untoward reaction such as infection.If at face's life-time service, then can there is the symptoms such as facial skin flushing, telangiectasis, Perioral Dermatitis, acne rosacea sample skin lesion.Long-term large-area use, can because being absorbed in body the infringement caused health, such as hypertension, diabetes, hydrability ulcer and Cushing's syndrome etc.Adopt have antipruritic, pain relieving, irritation, suppression escherichia coli and staphylococcus aureus growth, antiinflammatory, prevent secondary infection, promoting blood circulation and detoxication, local anesthesia effect raw material carry out scientific and reasonable compatibility, can use in the larger area of skin, contribute to epithelial proliferation, promote granulation tissue growth and wound wound healing, be conducive to often forming a scab with the wound of phenomenon of very itching, be unlikely infection of scratching, help wound decrustation; On the other hand because of the strong adhesion of pharmaceutical through skin, lasting medicine, miliaria of dispelling is effective with eczema, and can be used for treatment nonulceration chilblain.
Detailed description of the invention
The present invention is further illustrated for following examples.
Embodiment 1
Embodiment 1 raw material by mass percentage consists of: Radix Arnebiae extract 0.1%, medicine oil 5%, allantoin 6%, substrate adds to 100%.
Embodiment 2
Embodiment 2 raw material by mass percentage consists of: Radix Arnebiae extract 3%, medicine oil 10%, allantoin 8%, substrate adds to 100%.
Embodiment 3
Embodiment 3 raw material by mass percentage consists of: Radix Arnebiae extract 2%, medicine oil 3%, allantoin 8%, substrate adds to 100%.
Embodiment 4
Embodiment 4 raw material by mass percentage consists of: Radix Arnebiae extract 3%, medicine oil 15%, allantoin 10%, substrate adds to 100%.
Embodiment 5
Embodiment 5 raw material by mass percentage consists of: Radix Arnebiae extract 4%, medicine oil 20%, allantoin 0.5%, substrate adds to 100%.
Embodiment 6
Embodiment 6 raw material by mass percentage consists of: Radix Arnebiae extract 5%, medicine oil 22%, allantoin 5%, substrate adds to 100%.
In embodiment 1 ~ 6, the alkannin content by mass percentage >=30% in described Radix Arnebiae extract.No. CAS of Radix Arnebiae extract is 517-89-5.Described Radix Arnebiae extract extracts from Radix Arnebiae (Radix Lithospermi) and obtains, and is now commercial prod, domestic existing numerous manufacturer.
Described medicine oil raw material composition in mass ratio: Mentholum 2 ~ 3, thymol 1 ~ 2, Borneolum Syntheticum 0.5 ~ 1, wintergreen oil are 1 ~ 2.5, paeonol 2 ~ 5; Preferred Mentholum 2 ~ 2.5, thymol 1 ~ 1.5, Borneolum Syntheticum 0.5 ~ 0.8, wintergreen oil are 1 ~ 1.5, paeonol 2 ~ 4.
The unguentum that described substrate can adopt at least one in oil-in-water type ointment, water-in-oil type ointment, vaseline, high polymer etc. to make or gel.Described high polymer can select the Polyethylene Glycol etc. of different molecular weight.
The antipruritic eczema medicine of described compound recipe Radix Arnebiae (Radix Lithospermi) adopts following methods preparation:
Raw material is divided into aqueous phase (such as glycerol, water, sodium hydroxide, potassium hydroxide), oil phase (octadecanol, stearic acid, monoglyceride, vaseline) and medicine oil (Mentholum, thymol, Borneolum Syntheticum, wintergreen oil, paeonol), aqueous phase and allantoin are heated to 60 ~ 100 DEG C in kettle, oil phase is heated to 60 ~ 100 DEG C in oil cauldron, medicine oil stirs and dissolves each other, again by after aqueous phase and oil phase mixing and stirring, add the oil that is used as medicine and continue mixing and stirring emulsifying, to be cooled to room temperature.
The present invention is topical agent, is preferably unguentum.Its using method first cleans affected part, then get proper amount of medication and be applied to affected part, massage a moment, helps it to permeate, every day 2 ~ 3 times.
Below provide medication case of the present invention:
1, Chen, juvenile, very itches because eczema causes, causes wound infection after scratching, and medication was clearly better after 2 days, and medication was fully recovered after 5 days.
2, Liu, 2 years old, suffer from diaper rash, medication was fully recovered after 3 days.
3, Guo, female, old, eczema causes very itches, and medication was clearly better after 3 days, and medication is basic after 1 week cures.
4, Lin, baby, because of mosquito bite, causes redness, very itches, and medication was fully recovered after 2 days.
5, Wang, juvenile, very itch because long miliaria causes, medication was clearly better after 2 days, and medication was fully recovered after 4 days.
6, Wu, grow up, because eczema is very itched, medication was clearly better after 2 days, and medication was fully recovered after 4 days.
Claims (8)
1. the antipruritic eczema medicine of compound recipe Radix Arnebiae (Radix Lithospermi), is characterized in that its raw material by mass percentage consists of: Radix Arnebiae extract 0.1% ~ 5%, medicine oil 2% ~ 22%, allantoin 0.5% ~ 10%, substrate adds to 100%.
2. the antipruritic eczema medicine of a kind of compound recipe Radix Arnebiae (Radix Lithospermi) as claimed in claim 1, is characterized in that its raw material by mass percentage consists of: Radix Arnebiae extract 2% ~ 5%, medicine oil 5% ~ 15%, allantoin 5% ~ 10%, substrate adds to 100%.
3. the antipruritic eczema medicine of a kind of compound recipe Radix Arnebiae (Radix Lithospermi) as claimed in claim 1, is characterized in that the alkannin content by mass percentage >=30% in described Radix Arnebiae extract.
4. the antipruritic eczema medicine of a kind of compound recipe Radix Arnebiae (Radix Lithospermi) as claimed in claim 1, is characterized in that described medicine oil raw material composition in mass ratio: Mentholum 2 ~ 3, and thymol 1 ~ 2, Borneolum Syntheticum 0.5 ~ 1, wintergreen oil are 1 ~ 2.5, paeonol 2 ~ 5.
5. the antipruritic eczema medicine of a kind of compound recipe Radix Arnebiae (Radix Lithospermi) as claimed in claim 4, is characterized in that described medicine oil raw material composition in mass ratio: Mentholum 2 ~ 2.5, and thymol 1 ~ 1.5, Borneolum Syntheticum 0.5 ~ 0.8, wintergreen oil are 1 ~ 1.5, paeonol 2 ~ 4.
6. the antipruritic eczema medicine of a kind of compound recipe Radix Arnebiae (Radix Lithospermi) as claimed in claim 1, is characterized in that the unguentum that described substrate adopts at least one in oil-in-water type ointment, water-in-oil type ointment, vaseline, high polymer to make or gel.
7. the antipruritic eczema medicine of a kind of compound recipe Radix Arnebiae (Radix Lithospermi) as claimed in claim 6, is characterized in that described high polymer selects Polyethylene Glycol.
8. the antipruritic eczema medicine of a kind of compound recipe Radix Arnebiae (Radix Lithospermi) as claimed in claim 1, is characterized in that described medicine is unguentum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510016009.6A CN104490976A (en) | 2015-01-13 | 2015-01-13 | Compound comfrey itching relieving eczema treatment drug |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510016009.6A CN104490976A (en) | 2015-01-13 | 2015-01-13 | Compound comfrey itching relieving eczema treatment drug |
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| CN104490976A true CN104490976A (en) | 2015-04-08 |
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| CN201510016009.6A Pending CN104490976A (en) | 2015-01-13 | 2015-01-13 | Compound comfrey itching relieving eczema treatment drug |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106266189A (en) * | 2016-08-09 | 2017-01-04 | 朱夫 | Compound recipe Radix Arnebiae (Radix Lithospermi) mosquito-expelling and antipruritic cream and preparation method thereof |
| CN106692450A (en) * | 2016-12-16 | 2017-05-24 | 上海应象健康信息咨询有限公司 | Lithospermum and borneol cooling cream and preparation method thereof |
| CN112156128A (en) * | 2020-11-11 | 2021-01-01 | 苏州健雄职业技术学院 | Preparation method of multi-effect lithospermum paste for infants |
| CN114870721A (en) * | 2021-02-05 | 2022-08-09 | 陈立德 | Production process and automatic production equipment of antipruritic medicine |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1650995A (en) * | 2004-12-01 | 2005-08-10 | 陈立德 | Itching relieving medicament |
-
2015
- 2015-01-13 CN CN201510016009.6A patent/CN104490976A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1650995A (en) * | 2004-12-01 | 2005-08-10 | 陈立德 | Itching relieving medicament |
Non-Patent Citations (2)
| Title |
|---|
| 冯丹红等: "丹皮酚软膏治疗湿疹、皮炎64例疗效观察", 《中国实用医药》 * |
| 徐元贞等: "《新全实用药物手册》", 28 February 2005 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106266189A (en) * | 2016-08-09 | 2017-01-04 | 朱夫 | Compound recipe Radix Arnebiae (Radix Lithospermi) mosquito-expelling and antipruritic cream and preparation method thereof |
| CN106692450A (en) * | 2016-12-16 | 2017-05-24 | 上海应象健康信息咨询有限公司 | Lithospermum and borneol cooling cream and preparation method thereof |
| CN112156128A (en) * | 2020-11-11 | 2021-01-01 | 苏州健雄职业技术学院 | Preparation method of multi-effect lithospermum paste for infants |
| CN114870721A (en) * | 2021-02-05 | 2022-08-09 | 陈立德 | Production process and automatic production equipment of antipruritic medicine |
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Application publication date: 20150408 |