CN106619823A - Ointment for therapy of eczema and preparation method of same - Google Patents

Ointment for therapy of eczema and preparation method of same Download PDF

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Publication number
CN106619823A
CN106619823A CN201610897116.9A CN201610897116A CN106619823A CN 106619823 A CN106619823 A CN 106619823A CN 201610897116 A CN201610897116 A CN 201610897116A CN 106619823 A CN106619823 A CN 106619823A
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China
Prior art keywords
ointment
raw material
paeonol
allantoin
borneol
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CN201610897116.9A
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Chinese (zh)
Inventor
莫肯堂
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Liuzhou Science And Technology Ltd Surrounded By Mountains
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Liuzhou Science And Technology Ltd Surrounded By Mountains
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/30Zinc; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41661,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/555Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/61Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides an ointment for therapy of eczema and a preparation method of same. The ointment comprises, by weight, 1-3% of zinc carbonate, 0.1-1% of chlorhexidine gluconate, 1-2% of tea tree essential oil, 0.1-0.5% of paeonol, 0.1-2% of allantoin, 1-3% of sodium copper chlorophyllin, 2-8% of borneol, and the balanced being a substrate. The ointment is prepared from Western medicines with a gentle substrate, is low in usage amount, short in treatment course and quick in treatment effect, is convenient to take, is safe, is free of toxic and side effects, and can eliminate inflammation, resist bacteria, resolve swelling and relieve pain, and accelerate wound healing.

Description

It is a kind of to treat ointment of eczema and preparation method thereof
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of to treat ointment of eczema and preparation method thereof.
Background technology
Eczema(eczema)It is the struvite skin of a kind of common epidermis caused by various internal and external factors and high dermis Skin disease, symmetrical with fash diversity, violent itch, recurrent exerbation, easily develop into it is chronic be characterized, can betide any Age any position, any season, but often recur in the winter time or aggravate.In recent years the incidence of disease of eczema is in rising trend, this with Climate and Environment Variation, application of a large amount of chemicals in life is nervous, and rhythm of life is accelerated, and dietary structure changes equal There is relation.
At present the medicine for the treatment of eczema is a lot, is divided into Chinese medicine and Western medicine, and mostly action is slow for Chinese medicine, and drug treatment is longer, suffers from Person will bear prolonged slight illness, body and all be tormented for a long time at heart.
The content of the invention
In order to solve the above problems, present invention offer is a kind of to treat ointment of eczema and preparation method thereof, and the present invention's is wet Rash ointment is equipped with gentle ointment bases using Western medicine, and with consumption is few, short treating period, curative effect be fast, easy to carry, safety non-toxic pair The advantage of effect, being capable of anti-inflammatory, antibacterial, swelling and pain relieving, quickening wound healing.
The present invention is achieved through the following technical solutions:
A kind of ointment for treating eczema, including the raw material of following weight percentage:Zinc carbonate 1-3%, chlorhexidine gluconate It is 0.1-1%, tea tree ethereal oil 1-2%, Paeonol 0.1-0.5%, allantoin 0.1-2%, sodium copper chlorophyllin 1-3%, borneol 2-8%, remaining Measure as matrix.
Preferably, the ointment, including the raw material of following weight percentage:Zinc carbonate 2%, chlorhexidine gluconate 0.5%th, tea tree ethereal oil 2%, Paeonol 0.3%, allantoin 1%, sodium copper chlorophyllin 2%, borneol 6%, balance of matrix.
Preferably, the matrix includes the raw material of following weight percentage:Lauryl sodium sulfate 0.1-0.4%, tristearin Alcohol 8-12%, atoleine 4-6%, vaseline 10-20%, balance of water.
A kind of preparation method of the ointment for treating eczema, comprises the following steps:
(1)The raw material of each weight percentage is weighed, Paeonol is dissolved with a small amount of ethanol, obtain root bark of tree peony phenol solution;
(2)Stearyl alcohol, atoleine, vaseline, tea tree ethereal oil are placed in oil phase pot, heating water bath obtains oily to 70-80 DEG C Phase;
(3)Lauryl sodium sulfate, chlorhexidine gluconate, allantoin, borneol and water are placed in water phase pot, heating water bath is extremely 70-80 DEG C, obtain water phase;
(4)Under conditions of stirring, water is added in oil phase, heating water bath maintains the temperature at 70-80 DEG C, is stirred in partly solid Body shape, is cooled to 40-50 DEG C, is subsequently adding zinc carbonate, sodium copper chlorophyllin and root bark of tree peony phenol solution, continues to stir, cooling, i.e., .
Zinc carbonate is pharmaceutically being used as Derma-Guard.
Chlorhexidine gluconate, with great broad-spectrum antibacterial, bactericidal action, to gram-positive bacteria and gram-negative Property bacterium is effective.
Tea tree ethereal oil has bactericidal antiphlogistic, convergence pore, treatment cold, cough, rhinitis, asthma, improves dysmenorrhoea, the moon Jing is uncomfortable and the effects such as genital infection.
Paeonol has analgesia, anti-inflammatory, effect that is antipyretic and suppressing allergy.
Allantoin has promotion cell growth, accelerates the physiological functions such as wound healing, cutin-softening albumen, is skin trauma Good consolidant and antiulcer agents.Can be used as alleviating and treat xerodermia, scaling skin illness, skin ulcer, disappear Change road ulcer and inflammation, have good therapeutic effect to osteomyelitis, diabetes, cirrhosis, acne.
Sodium copper chlorophyllin:There is antitoxin, antiulcer, anti-hemolysis, protecting liver, lowering enzymes, inflammation-resisting itch-stopping.
Compared with prior art, advantages of the present invention and have the beneficial effect that:
1st, eczema ointment of the invention adopts various Western medicine, is equipped with gentle ointment bases, with consumption is few, short treating period, curative effect Hurry up, easy to carry, safe without toxic side effect advantage, can anti-inflammatory, antibacterial, swelling and pain relieving, accelerate wound healing.
2nd, method of the present invention process is simple, easily operated, is suitable for industrialized production.
Specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention, but protection scope of the present invention is not limited to following enforcement Example.
First, embodiment is prepared
Embodiment 1
A kind of ointment for treating eczema, including the raw material of following weight:Zinc carbonate 1g, chlorhexidine gluconate 0.1g, tea tree essence Oily 1g, Paeonol 0.1g, allantoin 0.1g, sodium copper chlorophyllin 1g, borneol 2g, plus matrix to 100g.
The matrix includes the raw material of following weight:Lauryl sodium sulfate 0.1g, stearyl alcohol 8g, it is atoleine 4g, all Intellectual circle 10g, balance of water.
Its preparation method, comprises the following steps:
(1)The raw material of each weight is weighed, Paeonol is dissolved with a small amount of ethanol, obtain root bark of tree peony phenol solution;
(2)Stearyl alcohol, atoleine, vaseline, tea tree ethereal oil are placed in oil phase pot, heating water bath to 70-80 DEG C makes it Melt, obtain oil phase;
(3)Lauryl sodium sulfate, chlorhexidine gluconate, allantoin, borneol and water are placed in water phase pot, heating water bath is extremely 70-80 DEG C, obtain water phase;
(4)Under conditions of stirring, water is added in oil phase, heating water bath maintains the temperature at 70-80 DEG C, is stirred in partly solid Body shape, is cooled to 40-50 DEG C, is subsequently adding zinc carbonate, sodium copper chlorophyllin and root bark of tree peony phenol solution, continues to stir, cooling, i.e., .
Embodiment 2
A kind of ointment for treating eczema, including the raw material of following weight:Zinc carbonate 3g, chlorhexidine gluconate 1g, tea tree ethereal oil 2g, Paeonol 0.5g, allantoin 2g, sodium copper chlorophyllin 3g, borneol 8g, plus matrix to 100g.
The matrix includes the raw material of following weight percentage:Lauryl sodium sulfate 0.4g, stearyl alcohol 12g, liquid Paraffin 6g, vaseline 20g, balance of water.
Its preparation method, comprises the following steps:
(1)The raw material of each weight is weighed, Paeonol is dissolved with a small amount of ethanol, obtain root bark of tree peony phenol solution;
(2)Stearyl alcohol, atoleine, vaseline, tea tree ethereal oil are placed in oil phase pot, heating water bath to 70-80 DEG C makes it Melt, obtain oil phase;
(3)Lauryl sodium sulfate, chlorhexidine gluconate, allantoin, borneol and water are placed in water phase pot, heating water bath is extremely 70-80 DEG C, obtain water phase;
(4)Under conditions of stirring, water is added in oil phase, heating water bath maintains the temperature at 70-80 DEG C, is stirred in partly solid Body shape, is cooled to 40-50 DEG C, is subsequently adding zinc carbonate, sodium copper chlorophyllin and root bark of tree peony phenol solution, continues to stir, cooling, i.e., .
Embodiment 3
A kind of ointment for treating eczema, including the raw material of following weight:Zinc carbonate 2g, chlorhexidine gluconate 0.5g, tea tree essence Oily 2g, Paeonol 0.3g, allantoin 1g, sodium copper chlorophyllin 2g, borneol 6g, plus matrix to 100g.
The matrix includes the raw material of following weight percentage:Lauryl sodium sulfate 0.3g, stearyl alcohol 10g, liquid Paraffin 5g, vaseline 15g, balance of water.
Its preparation method, comprises the following steps:
(1)The raw material of each weight is weighed, Paeonol is dissolved with a small amount of ethanol, obtain root bark of tree peony phenol solution;
(2)Stearyl alcohol, atoleine, vaseline, tea tree ethereal oil are placed in oil phase pot, heating water bath to 70-80 DEG C makes it Melt, obtain oil phase;
(3)Lauryl sodium sulfate, chlorhexidine gluconate, allantoin, borneol and water are placed in water phase pot, heating water bath is extremely 70-80 DEG C, obtain water phase;
(4)Under conditions of stirring, water is added in oil phase, heating water bath maintains the temperature at 70-80 DEG C, is stirred in partly solid Body shape, is cooled to 40-50 DEG C, is subsequently adding zinc carbonate, sodium copper chlorophyllin and root bark of tree peony phenol solution, continues to stir, cooling, i.e., .
Embodiment 4
A kind of ointment for treating eczema, including the raw material of following weight:Zinc carbonate 3g, chlorhexidine gluconate 0.2g, tea tree essence Oily 1g, Paeonol 0.5g, allantoin 0.5g, sodium copper chlorophyllin 3g, borneol 7g, plus matrix to 100g.
The matrix includes the raw material of following weight:Lauryl sodium sulfate 0.2g, stearyl alcohol 12g, it is atoleine 5g, all Intellectual circle 12g, balance of water.
Its preparation method, comprises the following steps:
(1)The raw material of each weight is weighed, Paeonol is dissolved with a small amount of ethanol, obtain root bark of tree peony phenol solution;
(2)Stearyl alcohol, atoleine, vaseline, tea tree ethereal oil are placed in oil phase pot, heating water bath obtains oily to 70-80 DEG C Phase;
(3)Lauryl sodium sulfate, chlorhexidine gluconate, allantoin, borneol and water are placed in water phase pot, heating water bath is extremely 70-80 DEG C, obtain water phase;
(4)Under conditions of stirring, water is added in oil phase, heating water bath maintains the temperature at 70-80 DEG C, is stirred in partly solid Body shape, is cooled to 40-50 DEG C, is subsequently adding zinc carbonate, sodium copper chlorophyllin and root bark of tree peony phenol solution, continues to stir, cooling, i.e., .
Embodiment 5
A kind of ointment for treating eczema, including the raw material of following weight:Zinc carbonate 2g, chlorhexidine gluconate 0.8g, tea tree essence Oily 2g, Paeonol 0.4g, allantoin 1.5g, sodium copper chlorophyllin 1g, borneol 3g, plus matrix to 100g.
The matrix includes the raw material of following weight:Lauryl sodium sulfate 0.3g, stearyl alcohol 10g, it is atoleine 5g, all Intellectual circle 16g, balance of water.
Its preparation method, comprises the following steps:
(1)The raw material of each weight is weighed, Paeonol is dissolved with a small amount of ethanol, obtain root bark of tree peony phenol solution;
(2)Stearyl alcohol, atoleine, vaseline, tea tree ethereal oil are placed in oil phase pot, heating water bath obtains oily to 70-80 DEG C Phase;
(3)Lauryl sodium sulfate, chlorhexidine gluconate, allantoin, borneol and water are placed in water phase pot, heating water bath is extremely 70-80 DEG C, obtain water phase;
(4)Under conditions of stirring, water is added in oil phase, heating water bath maintains the temperature at 70-80 DEG C, is stirred in partly solid Body shape, is cooled to 40-50 DEG C, is subsequently adding zinc carbonate, sodium copper chlorophyllin and root bark of tree peony phenol solution, continues to stir, cooling, i.e., .
2nd, clinical practice
1st, case selection
Select the age 15-50 year, Jing is diagnosed as the patient 100 of eczema.The wherein male sex 60, women 40.
2nd, therapeutic scheme
Using the ointment of the present embodiment 3, affected part 3 times is smeared daily, it is continuous to use 1 week.
3rd, curative effect determinate standard
It is invalid:Symptom is without alleviation or DeGrain.
Take a turn for the better:Symptom substantially mitigates, and most of erythema, papule, blister, itch disappear, and effect is obvious.
Cure:Eczema disappears, recovery from illness.
It is effective to take a turn for the better and cure sum.
4th, therapeutic effect, is shown in Table 1
Table 1:Therapeutic effect table
As a result show, treated using the embodiment of the present invention 3, cure rate is 70%, efficient is 98%, curative effect is high, without generation not Good reaction, using safety.

Claims (4)

1. a kind of ointment for treating eczema, it is characterised in that including the raw material of following weight percentage:Zinc carbonate 1-3%, Portugal Grape saccharic acid Chlorhexidine 0.1-1%, tea tree ethereal oil 1-2%, Paeonol 0.1-0.5%, allantoin 0.1-2%, sodium copper chlorophyllin 1-3%, Borneol 2-8%, balance of matrix.
2. ointment according to claim 1, it is characterised in that including the raw material of following weight percentage:Zinc carbonate 2%, Portugal It is grape saccharic acid Chlorhexidine 0.5%, tea tree ethereal oil 2%, Paeonol 0.3%, allantoin 1%, sodium copper chlorophyllin 2%, borneol 6%, balance of Matrix.
3. ointment according to claim 1, it is characterised in that the matrix includes the raw material of following weight percentage:Ten Sodium dialkyl sulfate 0.1-0.4%, stearyl alcohol 8-12%, atoleine 4-6%, vaseline 10-20%, balance of water.
4. the ointment of eczema is treated according to any one of claim 1-3, and its preparation method is comprised the following steps:
(1)The raw material of each weight percentage is weighed, Paeonol is dissolved with a small amount of ethanol, obtain root bark of tree peony phenol solution;
(2)Stearyl alcohol, atoleine, vaseline, tea tree ethereal oil are placed in oil phase pot, heating water bath to 70-80 DEG C makes it Melt, obtain oil phase;
(3)Lauryl sodium sulfate, chlorhexidine gluconate, allantoin, borneol and water are placed in water phase pot, heating water bath is extremely 70-80 DEG C, obtain water phase;
(4)Under conditions of stirring, water is added in oil phase, heating water bath maintains the temperature at 70-80 DEG C, is stirred in partly solid Body shape, is cooled to 40-50 DEG C, is subsequently adding zinc carbonate, sodium copper chlorophyllin and root bark of tree peony phenol solution, continues to stir, cooling, i.e., .
CN201610897116.9A 2016-10-14 2016-10-14 Ointment for therapy of eczema and preparation method of same Pending CN106619823A (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109381391A (en) * 2018-11-28 2019-02-26 张立萌 A kind of eczema ointment
CN109431842A (en) * 2018-11-28 2019-03-08 张立萌 A kind of children's eczema ointment
CN109985063A (en) * 2019-05-09 2019-07-09 石药集团远大(大连)制药有限公司 A kind of Efficient antibacterial pharmaceutical composition and the preparation method and application thereof
CN110538183A (en) * 2019-10-09 2019-12-06 吉林大学 Composition for preventing and treating infantile eczema and preparation method thereof
WO2021013315A1 (en) * 2019-07-22 2021-01-28 Mostafa Mariam Mohamed Kamel Ointment for diabetic foot ulcer treatment

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1557286A (en) * 2004-01-14 2004-12-29 北京可尔制药有限公司 Compound chlorhexidine acetate spray
CN102872158A (en) * 2012-07-02 2013-01-16 马应龙药业集团股份有限公司 External drug combination for curing eczema and preparation method thereof
CN104307032A (en) * 2014-11-05 2015-01-28 天津工业大学 Liquid dressing capable of stopping pain and bleeding, resisting bacteria and promoting wound healing

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1557286A (en) * 2004-01-14 2004-12-29 北京可尔制药有限公司 Compound chlorhexidine acetate spray
CN102872158A (en) * 2012-07-02 2013-01-16 马应龙药业集团股份有限公司 External drug combination for curing eczema and preparation method thereof
CN104307032A (en) * 2014-11-05 2015-01-28 天津工业大学 Liquid dressing capable of stopping pain and bleeding, resisting bacteria and promoting wound healing

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
樊志兵: "巧用炉甘石洗剂", 《大众卫生报》 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109381391A (en) * 2018-11-28 2019-02-26 张立萌 A kind of eczema ointment
CN109431842A (en) * 2018-11-28 2019-03-08 张立萌 A kind of children's eczema ointment
CN109381391B (en) * 2018-11-28 2021-11-26 张立萌 Eczema ointment
CN109431842B (en) * 2018-11-28 2022-01-18 张立萌 Eczema cream for children
CN109985063A (en) * 2019-05-09 2019-07-09 石药集团远大(大连)制药有限公司 A kind of Efficient antibacterial pharmaceutical composition and the preparation method and application thereof
CN109985063B (en) * 2019-05-09 2020-07-03 石药集团远大(大连)制药有限公司 Efficient antibacterial pharmaceutical composition and preparation method and application thereof
WO2021013315A1 (en) * 2019-07-22 2021-01-28 Mostafa Mariam Mohamed Kamel Ointment for diabetic foot ulcer treatment
CN110538183A (en) * 2019-10-09 2019-12-06 吉林大学 Composition for preventing and treating infantile eczema and preparation method thereof

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Application publication date: 20170510