CN106619823A - Ointment for therapy of eczema and preparation method of same - Google Patents
Ointment for therapy of eczema and preparation method of same Download PDFInfo
- Publication number
- CN106619823A CN106619823A CN201610897116.9A CN201610897116A CN106619823A CN 106619823 A CN106619823 A CN 106619823A CN 201610897116 A CN201610897116 A CN 201610897116A CN 106619823 A CN106619823 A CN 106619823A
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- CN
- China
- Prior art keywords
- ointment
- raw material
- paeonol
- allantoin
- borneol
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- 239000002674 ointment Substances 0.000 title claims abstract description 22
- 201000004624 Dermatitis Diseases 0.000 title claims abstract description 21
- 208000010668 atopic eczema Diseases 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 238000002560 therapeutic procedure Methods 0.000 title abstract 2
- UILPJVPSNHJFIK-UHFFFAOYSA-N Paeonol Chemical compound COC1=CC=C(C(C)=O)C(O)=C1 UILPJVPSNHJFIK-UHFFFAOYSA-N 0.000 claims abstract description 36
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 36
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 18
- 235000009024 Ceanothus sanguineus Nutrition 0.000 claims abstract description 18
- 240000003553 Leptospermum scoparium Species 0.000 claims abstract description 18
- 235000015459 Lycium barbarum Nutrition 0.000 claims abstract description 18
- FMRLDPWIRHBCCC-UHFFFAOYSA-L Zinc carbonate Chemical compound [Zn+2].[O-]C([O-])=O FMRLDPWIRHBCCC-UHFFFAOYSA-L 0.000 claims abstract description 18
- 229960000458 allantoin Drugs 0.000 claims abstract description 18
- HWDGVJUIHRPKFR-UHFFFAOYSA-I copper;trisodium;18-(2-carboxylatoethyl)-20-(carboxylatomethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18-dihydroporphyrin-21,23-diide-2-carboxylate Chemical compound [Na+].[Na+].[Na+].[Cu+2].N1=C(C(CC([O-])=O)=C2C(C(C)C(C=C3C(=C(C=C)C(=C4)[N-]3)C)=N2)CCC([O-])=O)C(=C([O-])[O-])C(C)=C1C=C1C(CC)=C(C)C4=N1 HWDGVJUIHRPKFR-UHFFFAOYSA-I 0.000 claims abstract description 18
- YLTGFGDODHXMFB-UHFFFAOYSA-N isoacetovanillon Natural products COC1=CC=C(C(C)=O)C=C1O YLTGFGDODHXMFB-UHFFFAOYSA-N 0.000 claims abstract description 18
- MLIBGOFSXXWRIY-UHFFFAOYSA-N paeonol Natural products COC1=CC=C(O)C(C(C)=O)=C1 MLIBGOFSXXWRIY-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229940079841 sodium copper chlorophyllin Drugs 0.000 claims abstract description 18
- 235000013758 sodium copper chlorophyllin Nutrition 0.000 claims abstract description 18
- 229910000010 zinc carbonate Inorganic materials 0.000 claims abstract description 18
- 235000004416 zinc carbonate Nutrition 0.000 claims abstract description 18
- 239000011667 zinc carbonate Substances 0.000 claims abstract description 18
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 17
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229940116229 borneol Drugs 0.000 claims abstract description 17
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 17
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229960003333 chlorhexidine gluconate Drugs 0.000 claims abstract description 16
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 claims abstract description 16
- 239000000341 volatile oil Substances 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 35
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 26
- 239000002994 raw material Substances 0.000 claims description 23
- 239000008236 heating water Substances 0.000 claims description 21
- 239000003921 oil Substances 0.000 claims description 18
- 239000011159 matrix material Substances 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- 240000005001 Paeonia suffruticosa Species 0.000 claims description 14
- 235000003889 Paeonia suffruticosa Nutrition 0.000 claims description 14
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 14
- 238000003756 stirring Methods 0.000 claims description 14
- YCSMVPSDJIOXGN-UHFFFAOYSA-N CCCCCCCCCCCC[Na] Chemical compound CCCCCCCCCCCC[Na] YCSMVPSDJIOXGN-UHFFFAOYSA-N 0.000 claims description 13
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 13
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 13
- 235000011152 sodium sulphate Nutrition 0.000 claims description 13
- 229940099259 vaseline Drugs 0.000 claims description 11
- 230000037237 body shape Effects 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 7
- 229960003010 sodium sulfate Drugs 0.000 claims description 7
- 239000007787 solid Substances 0.000 claims description 7
- NAOLWIGVYRIGTP-UHFFFAOYSA-N 1,3,5-trihydroxyanthracene-9,10-dione Chemical compound C1=CC(O)=C2C(=O)C3=CC(O)=CC(O)=C3C(=O)C2=C1 NAOLWIGVYRIGTP-UHFFFAOYSA-N 0.000 claims 2
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims 2
- 235000009754 Vitis X bourquina Nutrition 0.000 claims 2
- 235000012333 Vitis X labruscana Nutrition 0.000 claims 2
- 240000006365 Vitis vinifera Species 0.000 claims 2
- 235000014787 Vitis vinifera Nutrition 0.000 claims 2
- 229960003260 chlorhexidine Drugs 0.000 claims 2
- -1 Sodium dialkyl sulfate Chemical class 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 11
- 230000029663 wound healing Effects 0.000 abstract description 4
- 206010061218 Inflammation Diseases 0.000 abstract description 3
- 230000036407 pain Effects 0.000 abstract description 3
- 230000008961 swelling Effects 0.000 abstract description 3
- 241000894006 Bacteria Species 0.000 abstract description 2
- 230000004054 inflammatory process Effects 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 239000000758 substrate Substances 0.000 abstract 2
- 229940126673 western medicines Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 7
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 4
- 208000003251 Pruritus Diseases 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- 229940057995 liquid paraffin Drugs 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000003883 ointment base Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 206010048461 Genital infection Diseases 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010031252 Osteomyelitis Diseases 0.000 description 1
- 206010033733 Papule Diseases 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- CKMXBZGNNVIXHC-UHFFFAOYSA-L ammonium magnesium phosphate hexahydrate Chemical compound [NH4+].O.O.O.O.O.O.[Mg+2].[O-]P([O-])([O-])=O CKMXBZGNNVIXHC-UHFFFAOYSA-L 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 230000001147 anti-toxic effect Effects 0.000 description 1
- 230000000767 anti-ulcer Effects 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 239000003699 antiulcer agent Substances 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 229910052567 struvite Inorganic materials 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention provides an ointment for therapy of eczema and a preparation method of same. The ointment comprises, by weight, 1-3% of zinc carbonate, 0.1-1% of chlorhexidine gluconate, 1-2% of tea tree essential oil, 0.1-0.5% of paeonol, 0.1-2% of allantoin, 1-3% of sodium copper chlorophyllin, 2-8% of borneol, and the balanced being a substrate. The ointment is prepared from Western medicines with a gentle substrate, is low in usage amount, short in treatment course and quick in treatment effect, is convenient to take, is safe, is free of toxic and side effects, and can eliminate inflammation, resist bacteria, resolve swelling and relieve pain, and accelerate wound healing.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of to treat ointment of eczema and preparation method thereof.
Background technology
Eczema（eczema）It is the struvite skin of a kind of common epidermis caused by various internal and external factors and high dermis
Skin disease, symmetrical with fash diversity, violent itch, recurrent exerbation, easily develop into it is chronic be characterized, can betide any
Age any position, any season, but often recur in the winter time or aggravate.In recent years the incidence of disease of eczema is in rising trend, this with
Climate and Environment Variation, application of a large amount of chemicals in life is nervous, and rhythm of life is accelerated, and dietary structure changes equal
There is relation.
At present the medicine for the treatment of eczema is a lot, is divided into Chinese medicine and Western medicine, and mostly action is slow for Chinese medicine, and drug treatment is longer, suffers from
Person will bear prolonged slight illness, body and all be tormented for a long time at heart.
The content of the invention
In order to solve the above problems, present invention offer is a kind of to treat ointment of eczema and preparation method thereof, and the present invention's is wet
Rash ointment is equipped with gentle ointment bases using Western medicine, and with consumption is few, short treating period, curative effect be fast, easy to carry, safety non-toxic pair
The advantage of effect, being capable of anti-inflammatory, antibacterial, swelling and pain relieving, quickening wound healing.
The present invention is achieved through the following technical solutions：
A kind of ointment for treating eczema, including the raw material of following weight percentage：Zinc carbonate 1-3%, chlorhexidine gluconate
It is 0.1-1%, tea tree ethereal oil 1-2%, Paeonol 0.1-0.5%, allantoin 0.1-2%, sodium copper chlorophyllin 1-3%, borneol 2-8%, remaining
Measure as matrix.
Preferably, the ointment, including the raw material of following weight percentage：Zinc carbonate 2%, chlorhexidine gluconate
0.5%th, tea tree ethereal oil 2%, Paeonol 0.3%, allantoin 1%, sodium copper chlorophyllin 2%, borneol 6%, balance of matrix.
Preferably, the matrix includes the raw material of following weight percentage：Lauryl sodium sulfate 0.1-0.4%, tristearin
Alcohol 8-12%, atoleine 4-6%, vaseline 10-20%, balance of water.
A kind of preparation method of the ointment for treating eczema, comprises the following steps：
（1）The raw material of each weight percentage is weighed, Paeonol is dissolved with a small amount of ethanol, obtain root bark of tree peony phenol solution；
（2）Stearyl alcohol, atoleine, vaseline, tea tree ethereal oil are placed in oil phase pot, heating water bath obtains oily to 70-80 DEG C
Phase；
（3）Lauryl sodium sulfate, chlorhexidine gluconate, allantoin, borneol and water are placed in water phase pot, heating water bath is extremely
70-80 DEG C, obtain water phase；
（4）Under conditions of stirring, water is added in oil phase, heating water bath maintains the temperature at 70-80 DEG C, is stirred in partly solid
Body shape, is cooled to 40-50 DEG C, is subsequently adding zinc carbonate, sodium copper chlorophyllin and root bark of tree peony phenol solution, continues to stir, cooling, i.e.,
.
Zinc carbonate is pharmaceutically being used as Derma-Guard.
Chlorhexidine gluconate, with great broad-spectrum antibacterial, bactericidal action, to gram-positive bacteria and gram-negative
Property bacterium is effective.
Tea tree ethereal oil has bactericidal antiphlogistic, convergence pore, treatment cold, cough, rhinitis, asthma, improves dysmenorrhoea, the moon
Jing is uncomfortable and the effects such as genital infection.
Paeonol has analgesia, anti-inflammatory, effect that is antipyretic and suppressing allergy.
Allantoin has promotion cell growth, accelerates the physiological functions such as wound healing, cutin-softening albumen, is skin trauma
Good consolidant and antiulcer agents.Can be used as alleviating and treat xerodermia, scaling skin illness, skin ulcer, disappear
Change road ulcer and inflammation, have good therapeutic effect to osteomyelitis, diabetes, cirrhosis, acne.
Sodium copper chlorophyllin：There is antitoxin, antiulcer, anti-hemolysis, protecting liver, lowering enzymes, inflammation-resisting itch-stopping.
Compared with prior art, advantages of the present invention and have the beneficial effect that：
1st, eczema ointment of the invention adopts various Western medicine, is equipped with gentle ointment bases, with consumption is few, short treating period, curative effect
Hurry up, easy to carry, safe without toxic side effect advantage, can anti-inflammatory, antibacterial, swelling and pain relieving, accelerate wound healing.
2nd, method of the present invention process is simple, easily operated, is suitable for industrialized production.
Specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention, but protection scope of the present invention is not limited to following enforcement
Example.
First, embodiment is prepared
Embodiment 1
A kind of ointment for treating eczema, including the raw material of following weight：Zinc carbonate 1g, chlorhexidine gluconate 0.1g, tea tree essence
Oily 1g, Paeonol 0.1g, allantoin 0.1g, sodium copper chlorophyllin 1g, borneol 2g, plus matrix to 100g.
The matrix includes the raw material of following weight：Lauryl sodium sulfate 0.1g, stearyl alcohol 8g, it is atoleine 4g, all
Intellectual circle 10g, balance of water.
Its preparation method, comprises the following steps：
（1）The raw material of each weight is weighed, Paeonol is dissolved with a small amount of ethanol, obtain root bark of tree peony phenol solution；
（2）Stearyl alcohol, atoleine, vaseline, tea tree ethereal oil are placed in oil phase pot, heating water bath to 70-80 DEG C makes it
Melt, obtain oil phase；
（3）Lauryl sodium sulfate, chlorhexidine gluconate, allantoin, borneol and water are placed in water phase pot, heating water bath is extremely
70-80 DEG C, obtain water phase；
（4）Under conditions of stirring, water is added in oil phase, heating water bath maintains the temperature at 70-80 DEG C, is stirred in partly solid
Body shape, is cooled to 40-50 DEG C, is subsequently adding zinc carbonate, sodium copper chlorophyllin and root bark of tree peony phenol solution, continues to stir, cooling, i.e.,
.
Embodiment 2
A kind of ointment for treating eczema, including the raw material of following weight：Zinc carbonate 3g, chlorhexidine gluconate 1g, tea tree ethereal oil
2g, Paeonol 0.5g, allantoin 2g, sodium copper chlorophyllin 3g, borneol 8g, plus matrix to 100g.
The matrix includes the raw material of following weight percentage：Lauryl sodium sulfate 0.4g, stearyl alcohol 12g, liquid
Paraffin 6g, vaseline 20g, balance of water.
Its preparation method, comprises the following steps：
（1）The raw material of each weight is weighed, Paeonol is dissolved with a small amount of ethanol, obtain root bark of tree peony phenol solution；
（2）Stearyl alcohol, atoleine, vaseline, tea tree ethereal oil are placed in oil phase pot, heating water bath to 70-80 DEG C makes it
Melt, obtain oil phase；
（3）Lauryl sodium sulfate, chlorhexidine gluconate, allantoin, borneol and water are placed in water phase pot, heating water bath is extremely
70-80 DEG C, obtain water phase；
（4）Under conditions of stirring, water is added in oil phase, heating water bath maintains the temperature at 70-80 DEG C, is stirred in partly solid
Body shape, is cooled to 40-50 DEG C, is subsequently adding zinc carbonate, sodium copper chlorophyllin and root bark of tree peony phenol solution, continues to stir, cooling, i.e.,
.
Embodiment 3
A kind of ointment for treating eczema, including the raw material of following weight：Zinc carbonate 2g, chlorhexidine gluconate 0.5g, tea tree essence
Oily 2g, Paeonol 0.3g, allantoin 1g, sodium copper chlorophyllin 2g, borneol 6g, plus matrix to 100g.
The matrix includes the raw material of following weight percentage：Lauryl sodium sulfate 0.3g, stearyl alcohol 10g, liquid
Paraffin 5g, vaseline 15g, balance of water.
Its preparation method, comprises the following steps：
（1）The raw material of each weight is weighed, Paeonol is dissolved with a small amount of ethanol, obtain root bark of tree peony phenol solution；
（2）Stearyl alcohol, atoleine, vaseline, tea tree ethereal oil are placed in oil phase pot, heating water bath to 70-80 DEG C makes it
Melt, obtain oil phase；
（3）Lauryl sodium sulfate, chlorhexidine gluconate, allantoin, borneol and water are placed in water phase pot, heating water bath is extremely
70-80 DEG C, obtain water phase；
（4）Under conditions of stirring, water is added in oil phase, heating water bath maintains the temperature at 70-80 DEG C, is stirred in partly solid
Body shape, is cooled to 40-50 DEG C, is subsequently adding zinc carbonate, sodium copper chlorophyllin and root bark of tree peony phenol solution, continues to stir, cooling, i.e.,
.
Embodiment 4
A kind of ointment for treating eczema, including the raw material of following weight：Zinc carbonate 3g, chlorhexidine gluconate 0.2g, tea tree essence
Oily 1g, Paeonol 0.5g, allantoin 0.5g, sodium copper chlorophyllin 3g, borneol 7g, plus matrix to 100g.
The matrix includes the raw material of following weight：Lauryl sodium sulfate 0.2g, stearyl alcohol 12g, it is atoleine 5g, all
Intellectual circle 12g, balance of water.
Its preparation method, comprises the following steps：
（1）The raw material of each weight is weighed, Paeonol is dissolved with a small amount of ethanol, obtain root bark of tree peony phenol solution；
（2）Stearyl alcohol, atoleine, vaseline, tea tree ethereal oil are placed in oil phase pot, heating water bath obtains oily to 70-80 DEG C
Phase；
（3）Lauryl sodium sulfate, chlorhexidine gluconate, allantoin, borneol and water are placed in water phase pot, heating water bath is extremely
70-80 DEG C, obtain water phase；
（4）Under conditions of stirring, water is added in oil phase, heating water bath maintains the temperature at 70-80 DEG C, is stirred in partly solid
Body shape, is cooled to 40-50 DEG C, is subsequently adding zinc carbonate, sodium copper chlorophyllin and root bark of tree peony phenol solution, continues to stir, cooling, i.e.,
.
Embodiment 5
A kind of ointment for treating eczema, including the raw material of following weight：Zinc carbonate 2g, chlorhexidine gluconate 0.8g, tea tree essence
Oily 2g, Paeonol 0.4g, allantoin 1.5g, sodium copper chlorophyllin 1g, borneol 3g, plus matrix to 100g.
The matrix includes the raw material of following weight：Lauryl sodium sulfate 0.3g, stearyl alcohol 10g, it is atoleine 5g, all
Intellectual circle 16g, balance of water.
Its preparation method, comprises the following steps：
（1）The raw material of each weight is weighed, Paeonol is dissolved with a small amount of ethanol, obtain root bark of tree peony phenol solution；
（2）Stearyl alcohol, atoleine, vaseline, tea tree ethereal oil are placed in oil phase pot, heating water bath obtains oily to 70-80 DEG C
Phase；
（3）Lauryl sodium sulfate, chlorhexidine gluconate, allantoin, borneol and water are placed in water phase pot, heating water bath is extremely
70-80 DEG C, obtain water phase；
（4）Under conditions of stirring, water is added in oil phase, heating water bath maintains the temperature at 70-80 DEG C, is stirred in partly solid
Body shape, is cooled to 40-50 DEG C, is subsequently adding zinc carbonate, sodium copper chlorophyllin and root bark of tree peony phenol solution, continues to stir, cooling, i.e.,
.
2nd, clinical practice
1st, case selection
Select the age 15-50 year, Jing is diagnosed as the patient 100 of eczema.The wherein male sex 60, women 40.
2nd, therapeutic scheme
Using the ointment of the present embodiment 3, affected part 3 times is smeared daily, it is continuous to use 1 week.
3rd, curative effect determinate standard
It is invalid：Symptom is without alleviation or DeGrain.
Take a turn for the better：Symptom substantially mitigates, and most of erythema, papule, blister, itch disappear, and effect is obvious.
Cure：Eczema disappears, recovery from illness.
It is effective to take a turn for the better and cure sum.
4th, therapeutic effect, is shown in Table 1
Table 1：Therapeutic effect table
As a result show, treated using the embodiment of the present invention 3, cure rate is 70%, efficient is 98%, curative effect is high, without generation not
Good reaction, using safety.
Claims (4)
1. a kind of ointment for treating eczema, it is characterised in that including the raw material of following weight percentage：Zinc carbonate 1-3%, Portugal
Grape saccharic acid Chlorhexidine 0.1-1%, tea tree ethereal oil 1-2%, Paeonol 0.1-0.5%, allantoin 0.1-2%, sodium copper chlorophyllin 1-3%,
Borneol 2-8%, balance of matrix.
2. ointment according to claim 1, it is characterised in that including the raw material of following weight percentage：Zinc carbonate 2%, Portugal
It is grape saccharic acid Chlorhexidine 0.5%, tea tree ethereal oil 2%, Paeonol 0.3%, allantoin 1%, sodium copper chlorophyllin 2%, borneol 6%, balance of
Matrix.
3. ointment according to claim 1, it is characterised in that the matrix includes the raw material of following weight percentage：Ten
Sodium dialkyl sulfate 0.1-0.4%, stearyl alcohol 8-12%, atoleine 4-6%, vaseline 10-20%, balance of water.
4. the ointment of eczema is treated according to any one of claim 1-3, and its preparation method is comprised the following steps：
（1）The raw material of each weight percentage is weighed, Paeonol is dissolved with a small amount of ethanol, obtain root bark of tree peony phenol solution；
（2）Stearyl alcohol, atoleine, vaseline, tea tree ethereal oil are placed in oil phase pot, heating water bath to 70-80 DEG C makes it
Melt, obtain oil phase；
（3）Lauryl sodium sulfate, chlorhexidine gluconate, allantoin, borneol and water are placed in water phase pot, heating water bath is extremely
70-80 DEG C, obtain water phase；
（4）Under conditions of stirring, water is added in oil phase, heating water bath maintains the temperature at 70-80 DEG C, is stirred in partly solid
Body shape, is cooled to 40-50 DEG C, is subsequently adding zinc carbonate, sodium copper chlorophyllin and root bark of tree peony phenol solution, continues to stir, cooling, i.e.,
.
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Cited By (5)
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| CN109381391A (en) * | 2018-11-28 | 2019-02-26 | 张立萌 | A kind of eczema ointment |
| CN109431842A (en) * | 2018-11-28 | 2019-03-08 | 张立萌 | A kind of children's eczema ointment |
| CN109985063A (en) * | 2019-05-09 | 2019-07-09 | 石药集团远大(大连)制药有限公司 | A kind of Efficient antibacterial pharmaceutical composition and the preparation method and application thereof |
| CN110538183A (en) * | 2019-10-09 | 2019-12-06 | 吉林大学 | A composition for preventing and treating infantile eczema and its preparation method |
| WO2021013315A1 (en) * | 2019-07-22 | 2021-01-28 | Mostafa Mariam Mohamed Kamel | Ointment for diabetic foot ulcer treatment |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109381391A (en) * | 2018-11-28 | 2019-02-26 | 张立萌 | A kind of eczema ointment |
| CN109431842A (en) * | 2018-11-28 | 2019-03-08 | 张立萌 | A kind of children's eczema ointment |
| CN109381391B (en) * | 2018-11-28 | 2021-11-26 | 张立萌 | Eczema ointment |
| CN109431842B (en) * | 2018-11-28 | 2022-01-18 | 张立萌 | Eczema cream for children |
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| WO2021013315A1 (en) * | 2019-07-22 | 2021-01-28 | Mostafa Mariam Mohamed Kamel | Ointment for diabetic foot ulcer treatment |
| CN110538183A (en) * | 2019-10-09 | 2019-12-06 | 吉林大学 | A composition for preventing and treating infantile eczema and its preparation method |
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