CN102973800B - Puffball compound coating agent and preparation method thereof - Google Patents
Puffball compound coating agent and preparation method thereof Download PDFInfo
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- CN102973800B CN102973800B CN201210426719.2A CN201210426719A CN102973800B CN 102973800 B CN102973800 B CN 102973800B CN 201210426719 A CN201210426719 A CN 201210426719A CN 102973800 B CN102973800 B CN 102973800B
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- 239000011248 coating agent Substances 0.000 title abstract 4
- 241000133231 Marshallia caespitosa Species 0.000 title abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 45
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- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 16
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a puffball compound coating agent. Each 1000 g of the coating agent is mainly prepared from the following raw materials: 180 to 220 g of puffball, 90 to 110 g of coptis, 90 to 110 g of fructus forsythiae, 45 to 55 g of borneol, 18 to 22 g of bletilla rhizome adhesive pulp, 110 to 140 g of glycerin, 15 to 20 g of PVA-124 and 8 to 10 g of Tween-80, with the balance being ethanol. The coating agent has the efficacy of detumescence, detoxification, itching relieving and haemostasis, is used for treatment of ulcerative carbuncle, edema pains, traumatic bleeding and the like, can effectively isolate the surface of a wound and prevents contamination of the surface of the wound and local infection.
Description
Technical field
The invention belongs to liniment technical field, be specifically related to a kind of Lasiosphaera Seu Calvatia compound recipe liniment and preparation method thereof.This liniment has the effect of subduing swelling and detoxicating, antipruritic, hemostasis, can be used for carbuncle skin ulcer, swells and ache and traumatic hemorrhage etc.
Background technology
At present, be used for the treatment of carbuncle skin ulcer, swell and ache and the medicine for external use of traumatic hemorrhage a lot, but major part is all difficult to isolate wound surface completely, causes wound surface easily contaminated, thereby causes local infection.
Summary of the invention
The object of the invention is to provide a kind of Lasiosphaera Seu Calvatia compound recipe liniment and preparation method thereof.This liniment has the effect of subduing swelling and detoxicating, antipruritic, hemostasis, for carbuncle skin ulcer, swell and ache and the treatment of traumatic hemorrhage etc., can effectively isolate wound surface, avoids wound surface to pollute and local infection.
For achieving the above object, the present invention adopts following technical scheme:
A kind of Lasiosphaera Seu Calvatia compound recipe liniment, every 1000g liniment is mainly made by the raw material of following proportioning: Lasiosphaera Seu Calvatia 180～220g, Rhizoma Coptidis 90～110g, Fructus Forsythiae 90～110g, Borneolum Syntheticum 45～55g, mucilago salep 18～22g, glycerol 110～140g, PVA-124 15～20g, tween 80 8～10g, surplus is ethanol.
Concrete: described ethanol volumetric concentration is 70-80%.
The present invention's mucilago salep used can select ordinary city to sell product, also can make as follows: Pseudobulbus Bletillae (Rhizoma Bletillae) is mixed with its weight 8-12 water doubly, reflux, extract, 2-4 time, each 1-2 hour, merge extractive liquid,, is evaporated to the 3-4 of Pseudobulbus Bletillae (Rhizoma Bletillae) weight doubly, add ethanol to ethanol and account for 70% of liquor capacity total amount, filter, pulverize to obtain Rhizoma Bletillae gel semi-finished product after being deposited in 60 ℃ of decompression dryings, standby; The water dissolution (can heat in 90-95 ℃ of water-bath to urge it and dissolve) that adds Rhizoma Bletillae gel semi-finished product 2-3 times of weight during use, obtains.
The preparation method of described Lasiosphaera Seu Calvatia compound recipe liniment, it comprises the steps: to get in proportion each raw material, the Rhizoma Coptidis of pulverizing, Fructus Forsythiae are reinstated to 85～90%(with Lasiosphaera Seu Calvatia sporophore one and refer to volumetric concentration) alcohol dipping percolation after 36～48 hours, collect percolate concentrating under reduced pressure (preferably 50～60 ℃) and, to 450-500g, then add mucilago salep, glycerol, Borneolum Syntheticum and tween 80, to be dissolved after, add again PVA-124 aqueous solution, to be dissolved completely after, with ethanol, mend to 1000g, obtain.Be sub-packed in bottle, sealing.The about 10g of every bottled amount.
Concrete, described PVA-124 aqueous solution is that after being mixed with 100ml water by PVA-124, in 80 ± 5 ℃ of water-baths, heating for dissolving makes.
Liniment of the present invention is medicine for external use, and the used time is applied to affected part, 2 times on the one.This liniment has the effect of subduing swelling and detoxicating, antipruritic, hemostasis, can be used for carbuncle skin ulcer, swells and ache and traumatic hemorrhage etc.
Lasiosphaera Seu Calvatia is distributed more widely, and most areas is all on the books in the world.Lasiosphaera Seu Calvatia nearly all has distribution in China various places, and resource is abundanter.Lasiosphaera Seu Calvatia contains several amino acids, inorganic salt, also contains ergosterol, lipoids, gemmatein, calvatic acid, ascorbic acid, dehydrogenation ascorbic acid, and the trace element such as copper, zinc, ferrum, calcium, magnesium.The Lasiosphaera Seu Calvatia property of medicine is flat, acrid in the mouth, returns liver, lung, kidney, stomach warp.There is hemostasis, antibacterial, anticancer effect.Be used for clinically coughing disease, acute tonsillitis, pharyngitis, laryngitis, parotitis, facial erysipelas, gastropathy, haematemesis, epistaxis etc.
Rhizoma Coptidis bitter in the mouth, cold in nature, enter the heart, liver, stomach, large intestine channel, function heat clearing and damp drying, eliminating fire and detoxication.Be a kind of good heat-clearing and toxic substances removing antibiotic medicine, there is the effect of broad ectrum antibiotic.Be usually used in treating damp and hot interior steaming, feeling of fullness feeling of distension and oppression, irritated vomiting, dysentery, quench one's thirst, epidemic hemorrhagic conjunctivitis, swollen ulcer drug, otitis media, acute tonsillitis, pertussis, lobar pneumonia, epidemic cerebrospinal meningitis, cholecystitis etc., and there is anticancer, anti-radiation and promote the effect of cellular metabolism.
Fructus Forsythiae bitter in the mouth, cold nature.Enter the heart, lung, small intestine meridian.Heat-clearing and toxic substances removing, mass dissipating and swelling eliminating, dispelling wind and heat pathogens, have the title of " persons particularly liable to develop skin infection's panacea ".In Fructus Forsythiae peel, contain lignin, vinylbenzene class, triterpenes, Coumarins, phytosterin compound and saponin etc., forsythol is its antimicrobial component.The pharmacological action such as that Fructus Forsythiae has is antibacterial, heart tonifying, diuresis, town are told, is usually used in treating the diseases such as acute anemopyretic cold, laryngopharynx swelling and pain, macule, erysipelas, carbuncle sore tumefacting virus, tuberculous lymphadenitis, urinary tract infection.
Borneolum Syntheticum also claims Borneolum Syntheticum, Borneolum Syntheticum, Flos Mume brain, MEIHUA BINGPIAN etc., has the effect of the refreshment of having one's ideas straightened out, clearing away heat to alleviate pain, for calentura coma, convulsion faint, apoplexy syncope due to accumulation of phlegm, infantile convulsion expectorant fan, sore throat toothache, aphtha carbuncle and ulcer, conjunctival congestion.The less independent application of Borneolum Syntheticum, is commonly used for " priming and adjuvant drug ", and Chinese patent medicine has more Borneolum Syntheticum compatibility application, and in cardiovascular and cerebrovascular disease treatment, application is especially extensive.
Mucilago salep main component is Pseudobulbus Bletillae (Rhizoma Bletillae) colloid, and bletilla mannan, has certain toughness, plays certain auxiliary filming function, and it also has the effect of hemostasis, detumescence, sore, granulation promoting pain relieving in addition.PVA-124 is preferred filmogen; Tween 80 is as solubilizing agent, stabilizing agent; Glycerol plays dissolved substance, the effect of skin care; Ethanol is solvent, plays dissolving principal agent, antiseptical effect.
Liniment of the present invention adopts the painting membrane matrix of compound medicine and optimization, evident in efficacy, can effectively isolate wound surface, avoids wound surface to pollute and local infection, promotes cicatrix to disappear, and is better than general film-coated preparation.Filmogen and Lasiosphaera Seu Calvatia compound recipe liniment film forming are good, nontoxic, to skin nonirritant.In addition, liniment of the present invention is a kind of external preparation, and preparation technology is simple, without framed back material, without special installation, easy to use, must be used for the treatment of carbuncle skin ulcer, swell and ache and traumatic hemorrhage etc.
Compare with conventional external preparation; Lasiosphaera Seu Calvatia compound recipe liniment of the present invention treatment carbuncle skin ulcer, swell and ache and traumatic hemorrhage aspect have advantages of outstanding: 1), medicine directly embrocates or be sprayed on affected part; do not need wrapping; form the uniform medicine film of one deck; not only can prevent that medicine from coming off; and can prevent the evaporation of skin surface moisture and oozing out of tissue fluid, and be conducive to the absorption of medicine, played the effect of protection wound surface.2), wound surface is had to the effect that promotes remaining epithelial growth, be beneficial to cicatrix and disappear.3), this liniment is easy to use, neither pollution clothes, can make again wound surface avoid outside contamination, and have no side effect, patient is acceptant.
The specific embodiment
By specific embodiment, the present invention is described in further details below, but protection scope of the present invention is not limited to this.
Embodiment 1 and 2 mucilago saleps used make as follows: Pseudobulbus Bletillae (Rhizoma Bletillae) is mixed with the water of 10 times of its weight, reflux, extract, 3 times, each 1.2 hours, merge extractive liquid,, be evaporated to 3.5 times of Pseudobulbus Bletillae (Rhizoma Bletillae) weight, add ethanol to ethanol and account for 70% of liquor capacity total amount, filter, after being deposited in 60 ℃ of decompression dryings, pulverize to obtain Rhizoma Bletillae gel semi-finished product, standby; The water dissolution that adds Rhizoma Bletillae gel semi-finished product 2 times of weight during use, obtains.
embodiment 1:
A kind of Lasiosphaera Seu Calvatia compound recipe liniment, every 1000g liniment is mainly made by the raw material of following proportioning: Lasiosphaera Seu Calvatia 220g, Rhizoma Coptidis 90g, Fructus Forsythiae 100g, Borneolum Syntheticum 55g, mucilago salep 18g, glycerol 125g, PVA-124 16g, tween 80 8.5g, surplus is the ethanol of volumetric concentration 80%.
The preparation method of described Lasiosphaera Seu Calvatia compound recipe liniment, it comprises the steps: to get in proportion each raw material, the Rhizoma Coptidis of pulverizing, Fructus Forsythiae are reinstated to 85% alcohol dipping percolation after 36 hours with Lasiosphaera Seu Calvatia sporophore one, collect percolate and be also evaporated to 500g, then add mucilago salep, glycerol, Borneolum Syntheticum and tween 80, to be dissolved after, add again PVA-124 aqueous solution, to be dissolved completely after, with the ethanol of volumetric concentration 80%, mend to 1000g, obtain.Be sub-packed in bottle, sealing.Described PVA-124 aqueous solution is that after being mixed with 100ml water by PVA-124, in 80 ℃ of water-baths, heating for dissolving makes.
embodiment 2
A kind of Lasiosphaera Seu Calvatia compound recipe liniment, every 1000g liniment is mainly made by the raw material of following proportioning: Lasiosphaera Seu Calvatia 200g, Rhizoma Coptidis 100g, Fructus Forsythiae 100g, Borneolum Syntheticum 50g, mucilago salep 20g, glycerol 125g, PVA-124 15g, tween 80 10g, surplus is the ethanol of volumetric concentration 70%.
The preparation method of described Lasiosphaera Seu Calvatia compound recipe liniment, it comprises the steps: to get in proportion each raw material, the Rhizoma Coptidis of pulverizing, Fructus Forsythiae are reinstated to 90% alcohol dipping percolation after 48 hours with Lasiosphaera Seu Calvatia sporophore one, collect percolate and be also evaporated to 480g, then add mucilago salep, glycerol, Borneolum Syntheticum and tween 80, to be dissolved after, add again PVA-124 aqueous solution, to be dissolved completely after, with the ethanol of volumetric concentration 70%, mend to 1000g, obtain.Be sub-packed in bottle, sealing.Described PVA-124 aqueous solution is that after being mixed with 100ml water by PVA-124, in 80 ± 5 ℃ of water-baths, heating for dissolving makes.
embodiment 3
A kind of Lasiosphaera Seu Calvatia compound recipe liniment, every 1000g liniment is mainly made by the raw material of following proportioning: Lasiosphaera Seu Calvatia 180g, Rhizoma Coptidis 90g, Fructus Forsythiae 110g, Borneolum Syntheticum 55g, mucilago salep 22g, glycerol 140g, PVA-124 20g, tween 80 8g, surplus is the ethanol of volumetric concentration 70%.
The preparation method of described Lasiosphaera Seu Calvatia compound recipe liniment, with reference to embodiment 2.
For verifying the drug effect of Lasiosphaera Seu Calvatia compound recipe liniment of the present invention, spy tests as follows.
the clinical diagnosis of carbuncle skin ulcer:infect part and be aubergine swelling, exceed body surface, obscure boundary, focus surface is a plurality of " pus heads " as seen, have severe pain; Regional area lymphadenectasis; Can there be the General Symptomies such as shiver with cold, high hot, weak, headache.From the beginning of time, local skin has the flat lump of inflammatory infiltration of red, swollen, hot a, pain, color is dark red, indefinite border, gradually to surrounding and deep tissue development.Affected part suppuration in 1～2 week, downright bad, ulceration, there are a plurality of routed holes on surface, and downright bad tissue and pus are from the hole discharge of bursting.When serious, whole affected part is entirely downright bad, and surface skin comes off completely, forms a dark huge ulcer.By newborn granulation tissue, replaced, after recovery from illness, form cicatrix.Be apt to occur in cervical region dorsal part, secondly, back.Also can occur in any position of whole body.
criterion of therapeutical effect:
Cure: red and swollen disappearance, skin is without lump, presses painlessly, clinical sign disappears, more after affected part without obvious cicatrix.
Take a turn for the better: clinical sign disappears substantially, red and swollen, pain obviously alleviates, and local skin lump obviously reduces.
Invalid: clinical sign is unchanged, red swelling of the skin, pain, lump disappear not obvious.
For showing the therapeutic effect of Lasiosphaera Seu Calvatia compound recipe liniment of the present invention, through 52 examples (wherein male 36 examples, female's 16 examples, 18～52 years old age) carbuncle skin ulcer patient clinical, observe, smear and use liniment of the present invention, clinical cure 39 examples, 13 examples that take a turn for the better, total effective rate 100%.
By model case, further set forth below the beneficial effect of liniment of the present invention.
Case 1:
Lee, man, 32 years old.When medical, back and buttocks have a plurality of carbuncle skin ulcers, and the aubergine swelling of carbuncle skin ulcer position touches and has burning sensation with hands, pain have lump sense while pressing; Wherein the red and swollen pain of buttocks carbuncle, is cellular; There is routed hole on carbuncle of gluteal region skin ulcer surface, has pus to flow out, and hurt like hell, is on tenterhooks.Before medical, with gentian voiet, smear, effect is bad, does not use other drug.Adopt local routine disinfection, remove pus and clean wound, smear the embodiment of the present invention 1 Lasiosphaera Seu Calvatia compound recipe liniment and treat 1 week, redness fades away, healing gradually in routed hole, continues medication one week, and lump disappears, touch affected part is painless, after strengthen again consolidating 3 days, cure.More after, affected part is without clear scar, without recurrence.
Case 2:
Wu, man, 21 years old, student.How carbuncle of gluteal region skin ulcer, as cellular, festers, has pus to flow out, and pruritus, hurt like hell, be on tenterhooks.And with heating paresthesia, survey 37.8 ℃ of body temperature, can not sleep round the clock.Alcohol disinfecting, smears PIKANGWANG effect and does not show.With hydrogen peroxide, removing after the pus of affected part, after the surrounding skin of the clean affected part of ethanol, smear the embodiment of the present invention 2 Lasiosphaera Seu Calvatia compound recipe liniment treatment 3 days, heals gradually in the position of festering, pruritus, pain relief, and body temperature transfers to normally; Continue to smear medication one week, the skin cunning that flattens, touches affected part painless, then cures.More after, affected part is without obvious spot, without recurrence.
This Lasiosphaera Seu Calvatia compound recipe liniment is for the treatment of traumatic hemorrhage (being mainly used in slight external haemorrhage, as skin minor trauma, knife injury etc.), through 27 examples (wherein male 18 examples, female's 9 examples, 21～46 years old age) patient clinical, observe, smear and use liniment of the present invention, clinical cure 27 examples, effective percentage is 100%.
Model case: Wang, man, 37 years old, workman.During carrying thing, left arm wrist place is scratched by ironware, skin injury, and wound length is less than 3cm, deeply be less than 3mm, smear the embodiment of the present invention 1 Lasiosphaera Seu Calvatia compound recipe liniment after iodine disinfection wound, after 3 minutes, blood only, smear continuously 7 days, wound healing, without obvious cicatrix.
Claims (4)
1. a Lasiosphaera Seu Calvatia compound recipe liniment, it is characterized in that: every 1000g liniment is made by the raw material of following proportioning: Lasiosphaera Seu Calvatia 180～220g, Rhizoma Coptidis 90～110g, Fructus Forsythiae 90～110g, Borneolum Syntheticum 45～55g, mucilago salep 18～22g, glycerol 110～140g, PVA-124 15～20g, tween 80 8～10g, surplus is ethanol; Described mucilago salep makes as follows: Pseudobulbus Bletillae (Rhizoma Bletillae) is mixed with its weight 8-12 water doubly, reflux, extract, 2-4 time, each 1-2 hour, merge extractive liquid,, be evaporated to the 3-4 of Pseudobulbus Bletillae (Rhizoma Bletillae) weight doubly, add ethanol to ethanol and account for 70% of liquor capacity total amount, filter, after precipitation decompression drying, pulverize to obtain Rhizoma Bletillae gel semi-finished product, standby; The water dissolution that adds Rhizoma Bletillae gel semi-finished product 2-3 times of weight during use, obtains.
2. Lasiosphaera Seu Calvatia compound recipe liniment as claimed in claim 1, is characterized in that: described ethanol volumetric concentration is 70-80%.
3. the preparation method of Lasiosphaera Seu Calvatia compound recipe liniment described in claim 1 or 2, it is characterized in that, comprise the steps: to get in proportion each raw material, the Rhizoma Coptidis of pulverizing, Fructus Forsythiae are reinstated to 85～90% alcohol dipping percolation after 36～48 hours with Lasiosphaera Seu Calvatia sporophore one, collect percolate and be also evaporated to 450-500g, then add mucilago salep, glycerol, Borneolum Syntheticum and tween 80, after to be dissolved, then add PVA-124 aqueous solution, to be dissolved completely after, with ethanol, mend to 1000g, obtain.
4. the preparation method of Lasiosphaera Seu Calvatia compound recipe liniment as claimed in claim 3, is characterized in that, described PVA-124 aqueous solution is that after being mixed with 100ml water by PVA-124, in 80 ± 5 ℃ of water-baths, heating for dissolving makes.
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| CN108635421A (en) * | 2018-07-12 | 2018-10-12 | 李宝 | Summer skin abrasion medication |
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| CN101648002A (en) * | 2008-08-13 | 2010-02-17 | 北京和润创新医药科技发展有限公司 | Medicinal composition for treating skin injury and ulcer and application thereof |
| CN102335403A (en) * | 2011-10-09 | 2012-02-01 | 许俊斋 | Medicine for treating thyroid cancer and malignant adenolymphoma |
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| CN101648002A (en) * | 2008-08-13 | 2010-02-17 | 北京和润创新医药科技发展有限公司 | Medicinal composition for treating skin injury and ulcer and application thereof |
| CN102335403A (en) * | 2011-10-09 | 2012-02-01 | 许俊斋 | Medicine for treating thyroid cancer and malignant adenolymphoma |
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