CN104001084A - Traditional Chinese medicine ointment for treating PICC (Peripherally Inserted Central Catheter) local infection and preparation method thereof - Google Patents
Traditional Chinese medicine ointment for treating PICC (Peripherally Inserted Central Catheter) local infection and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine ointment for treating PICC (Peripherally Inserted Central Catheter) local infection, and a preparation method of the ointment. The ointment is prepared from the following components in parts by weight: pseudo-ginseng, yellow lead, dragon's blood, caulis spatholobi, curcuma zedoary, rheum officinale, trollflower, senecio scandens, eclipta alba, strophanthus divaricatus, honeysuckle, andrographis paniculata, tuber fleeceflower stem, gastrodia elata, notopterygium root, radix saposhnikoviae, typhonium giganteum, rosin, folium isatidis, kaempferiae, lalang grass rhizome, arctium lappa, flos chrysanthemi, radix sophorae flavescentis and coptis chinensis. The ointment is remarkable in curative effect on PICC local infection, rapid in curative effect, definite in medicine effect, low in cost of raw materials, simple to prepare, stable in medicine effect, free of toxic or side effect or untoward effect, and wide in market application prospect.
Description
Technical field
The invention belongs to Chinese materia medica technical field, be specifically related to traditional Chinese herb medicine of a kind of PICC for the treatment of local infection and preparation method thereof.
Background technology
The advantages such as protection that patient vessel is grown, is beneficial to, indwelling time simple to operate with it through Peripherally inserted central catheter (peripherally inserted central catheter, PICC) are widely used in medium-term and long-term venous transfusion person, old transfusion person and the rescue to large-area burns, major operation, critical patient.Also there is some complication and danger simultaneously.Putting the rear point of puncture surrounding skin infection of pipe is exactly one of them, has bibliographical information, and this sick infection fatality rate is 3%.To clinical nursing activity, bring a lot of inconvenience, also to patient, bring many misgivings simultaneously.
Summary of the invention
In order to overcome deficiency of the prior art, the invention provides traditional Chinese herb medicine of a kind of PICC for the treatment of local infection and preparation method thereof, PICC local infection is had to significant curative effect.
In order to solve the problems of the technologies described above, the technical solution used in the present invention is as follows: a kind of traditional Chinese herb medicine for the treatment of PICC local infection and preparation method thereof, is characterized in that: each component by following parts by weight forms:
5～20 parts of Radix Notoginseng, 1～15 part, Plumbum preparatium, 1～5 part of Sanguis Draxonis, 5～20 parts of Caulis Spatholobis, 1～10 part of Rhizoma Curcumae, 10～20 parts of Radix Et Rhizoma Rhei, 10～20 parts of Flos Trolliis, 1～10 part of Herba Hieracii Umbellati, 5～15 parts of Herba Ecliptaes, 5～20 parts of Folium Microcoris paniculataes, 10～30 parts of Flos Loniceraes, 10～20 parts of Herba Andrographis, 1～10 part of Caulis Polygoni Multiflori, 5～20 parts of Radix Sophorae Flavescentiss, 5～20 parts of Rhizoma Coptidis, 1～20 part, Rhizoma Gastrodiae, 1～20 part of Rhizoma Et Radix Notopterygii, 5～20 parts of Radix Saposhnikoviaes, 1～20 part of Herba Typhonii gigantei, 5～20 parts of Colophonium, 1～20 part of Folium Isatidis, 1～30 part of husky Rhizoma Zingiberis Recens, 10～50 parts of Rhizoma Imperataes, 1～10 part of Fructus Arctii, 1～30 part of Flos Chrysanthemi.
Raw material composition and the parts by weight of making described effective ingredient also can be: 5～20 parts of Radix Notoginseng, 1～15 part, Plumbum preparatium, 1～5 part of Sanguis Draxonis, 5～20 parts of Caulis Spatholobis, 1～10 part of Rhizoma Curcumae, 10～20 parts of Radix Et Rhizoma Rhei, 10～20 parts of Flos Trolliis, 1～10 part of Herba Hieracii Umbellati, 5～15 parts of Herba Ecliptaes, 5～20 parts of Folium Microcoris paniculataes, 20～30 parts of Flos Loniceraes, 15～20 parts of Herba Andrographis, 5～10 parts of Caulis Polygoni Multiflori, 10～20 parts of Radix Sophorae Flavescentiss, 10～20 parts of Rhizoma Coptidis, 5～20 parts, Rhizoma Gastrodiae, 5～20 parts of Rhizoma Et Radix Notopterygiis, 10～20 parts of Radix Saposhnikoviaes, 10～20 parts of Herba Typhonii gigantei, 5～20 parts of Colophonium, 10～20 parts of Folium Isatidiss, 20～30 parts of husky Rhizoma Zingiberis Recens, 20～50 parts of Rhizoma Imperataes, 5～10 parts of Fructus Arctiis, 10～30 parts of Flos Chrysanthemis.
A kind of traditional Chinese herb medicine for the treatment of PICC local infection and preparation method thereof, is characterized in that: comprise following processing step:
(1) Radix Notoginseng, Colophonium, Flos Trollii and Herba Hieracii Umbellati are cleaned, dried, pulverize, grind to form fine powder;
(2) Plumbum preparatium, Sanguis Draxonis, Caulis Spatholobi, Rhizoma Curcumae, Radix Et Rhizoma Rhei, Herba Ecliptae, Folium Microcoris paniculatae, Flos Lonicerae, Herba Andrographis, Caulis Polygoni Multiflori, Radix Sophorae Flavescentis, Rhizoma Coptidis, Rhizoma Gastrodiae, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae, Herba Typhonii gigantei, Folium Isatidis, husky Rhizoma Zingiberis Recens, Rhizoma Imperatae, Fructus Arctii and Flos Chrysanthemi are cleaned, dry, pulverize, cross 100 mesh sieves, decocting three times, merge three times filtrate, the concentrated extracted extract of getting angry;
(3) described fine powder and extractum CO60 sterilizing, irradiation dose 8k.
(4) step (1) fine powder and step (2) extractum are ground to evenly jointly, add paste adjuvant, continue to be ground to into cream.
Described paste adjuvant also comprises wetting agent, antiseptic, thickening agent, antioxidant and transdermal enhancer.
Theoretical foundation of the present invention: < < Compendium of Materia Medica > > records Radix Notoginseng effect for hemostasis, loose blood, analgesic therapy; Gold sword arrow wound, fall and flutter flogging injury, blood and go out more than person, chew rotten painting or for it is mixed in end, its blood stop; Also main haematemesis, epistaxis, hematochezia, dysentery, metrorrhagia, incessant menorrhea, puerperal stagnant blood not under, blood fortune, blood pain, Akamu, carbuncle, tiger stings, all diseases of snakebite; Externally applied toxicity removing and granulation promoting.Plumbum preparatium has the effect of parasite killing for oral administration, preventing the attack (or recurrence) of malaria.Sanguis Draxonis has the effect of dissipating blood stasis analgesic therapy, hemostasia and promoting granulation.Caulis Spatholobi enrich blood promoting the circulation of blood, the meridian dredging.Rhizoma Curcumae has the function of removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving, promoting the circulation of QI to relieve pain, removing blood stasis removing food stagnancy, promoting digestion and removing stagnation.Radix Et Rhizoma Rhei has the effect of attacking stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, removing toxic substances.
The effect of Flos Trollii heat-clearing and toxic substances removing.Herba Hieracii Umbellati has the effect of heat-clearing and toxic substances removing, improving acuity of vision and removing nebula, killing parasites for relieving itching.Herba Ecliptae has nourishing the liver and kidney, cooling blood for hemostasis, can control the diseases such as various haematemesis, enterorrhagia.Folium Microcoris paniculatae has clearing away summer-heat, helps digestion, clears phlegm.Flos Lonicerae is cold in nature, and sweet in the mouth enters lung, the heart, stomach warp, has the effect of heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treatment wind, cures mainly the diseases such as disease under distension, epidemic febrile disease heating, pyretic toxicity carbuncle and ulcer and tumor.Herba Andrographis has the effect of heat-clearing and toxic substances removing, removing heat from blood detumescence.Caulis Polygoni Multiflori has nourishing heart, calms the nerves, dredging collateral, the effect of dispeling the wind.Radix Sophorae Flavescentis has the effect of heat clearing and damp drying.
Rhizoma Coptidis has the function of heat clearing and damp drying, eliminating fire and detoxication.Rhizoma Gastrodiae has the effect of endogenous wind stopping and arresting convulsion, controls dizzy pupil, wind syndrome of head headache, numb limbs and tense tendons, hemiplegia, aphasia and pediatric epilepsy scared wind symptom.Rhizoma Et Radix Notopterygii has loose exterior cold, wind-damp dispelling, sharp joint, pain relieving, main affection of exogenous wind-cold, lossless, the edema due to wind pathogen edema of having a headache, sore swollen toxin, for impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffer from a deficiency of the kidney breathe heavily, Diarrhoea; External curing vitiligo, speckle are bald; Induce sweat cold expelling, expelling wind and dampness, pain relieving.Radix Saposhnikoviae effect is expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic, cures mainly: affection of exogenous wind-cold, headache general pain, rheumatic arthralgia, joint are ached, stomachache is had loose bowels, discharging fresh blood stool, tetanus, rubella pruritus, skin infection from the beginning of.
Herba Typhonii gigantei has drying dampness to eliminate phlegm, expellings wind and relieving convulsion, the effect of detoxicating and resolving stagnation of pathogens, and the expectorant that can dispel the wind, by cold-damp, spasmolytic is controlled headache, facial hemiparalysis, hemiplegia, tetanus, traumatic injury impairment caused by overstrain, numb limbs and tense tendons, aphasia due to apoplexy, lymphoid tuberculosis, snake bite and insect sting etc.Colophonium have dispel the wind, dampness, evacuation of pus, draw out pus by applying a plaster to the affected part, granulation promoting, pain relieving, control carbuncle, furunculosis, hemorrhoid complicated by anal fistula, malignant boil, scabies, in vain bald, incised wound, sprain, rheumatic arthralgia and leprosy pruritus.Folium Isatidis has the effect of clearing away heat-damp and promoting diuresis and removing pathogenic heat from blood and toxic substance from the body, be used for preventing and treating epidemic cerebrospinal meningitis, epidemic encephalitis type B, the headache that cures cold, heating, measles complicated pneumonia, mumps, tonsillitis, infectious hepatitis, dysentery, urinary tract infection.
Husky Jiang Gongneng cures mainly as circulation of qi promoting warming middle-JIAO, helps digestion, pain relieving, for septum pectorale distension, coldness and pain in the epigastrium, diet, does not disappear.Rhizoma Imperatae has removing heat from blood, hemostasis, heat clearing away, diuresis, controls calentura excessive thirst, haematemesis, epistaxis, lung-heat dyspnea with rapid respiration, gastric heat hiccup, gonorrhea, dysuria, edema, jaundice.Fructus Arctii has the effect of dispelling wind and heat pathogens, lung qi dispersing rash, sore-throat relieving eliminating stagnation, removing toxic substances and promoting subsidence of swelling, belongs to wind-heat-dispersing medicinal in diaphoretic medicine.Flos Chrysanthemi has the effect of dispelling wind, heat clearing away, improving eyesight, removing toxic substances.
The present invention compared with prior art, has following beneficial effect: the present invention is remarkable to PICC local infection therapeutic effect; Medicine of the present invention adopts pure Chinese medicinal preparation, and all medicine compatibilities, bring out the best in each other, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing antiinflammatory; Curative effect of the present invention is fast, and effect is remarkable, and drug effect is definite, and raw material is cheap, and preparation is simple, and efficacy stability, has no side effect and untoward reaction, has wide market application foreground.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material of effective ingredient of the present invention forms and parts by weight are: 5 parts of Radix Notoginseng, 1 part, Plumbum preparatium, 1 part of Sanguis Draxonis, 5 parts of Caulis Spatholobis, 1 part of Rhizoma Curcumae, 10 parts of Radix Et Rhizoma Rhei, 10 parts of Flos Trolliis, 1 part of Herba Hieracii Umbellati, 5 parts of Herba Ecliptaes, 5 parts of Folium Microcoris paniculataes, 20 parts of Flos Loniceraes, 15 parts of Herba Andrographis, 5 parts of Caulis Polygoni Multiflori, 10 parts of Radix Sophorae Flavescentiss, 10 parts of Rhizoma Coptidis, 5 parts, Rhizoma Gastrodiae, 5 parts of Rhizoma Et Radix Notopterygiis, 10 parts of Radix Saposhnikoviaes, 10 parts of Herba Typhonii gigantei, 5 parts of Colophonium, 10 parts of Folium Isatidiss, 20 parts of husky Rhizoma Zingiberis Recens, 20 parts of Rhizoma Imperataes, 5 parts of Fructus Arctiis, 10 parts of Flos Chrysanthemis.
Above-mentioned ointment preparation process is:
(1) Radix Notoginseng, Colophonium, Flos Trollii and Herba Hieracii Umbellati are cleaned, dried, pulverize, grind to form fine powder;
(2) Plumbum preparatium, Sanguis Draxonis, Caulis Spatholobi, Rhizoma Curcumae, Radix Et Rhizoma Rhei, Herba Ecliptae, Folium Microcoris paniculatae, Flos Lonicerae, Herba Andrographis, Caulis Polygoni Multiflori, Radix Sophorae Flavescentis, Rhizoma Coptidis, Rhizoma Gastrodiae, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae, Herba Typhonii gigantei, Folium Isatidis, husky Rhizoma Zingiberis Recens, Rhizoma Imperatae, Fructus Arctii and Flos Chrysanthemi are cleaned, dry, pulverize, cross 100 mesh sieves, decocting three times, merge three times filtrate, the concentrated extracted extract of getting angry;
(3) described fine powder and extractum CO60 sterilizing, irradiation dose 8k.
(4) step (1) fine powder and step (2) extractum are ground to evenly jointly, add paste adjuvant, continue to be ground to into cream.
Described paste adjuvant also comprises wetting agent, antiseptic, thickening agent, antioxidant and transdermal enhancer.
Embodiment 2
The raw material of effective ingredient of the present invention forms and parts by weight are: 20 parts of Radix Notoginseng, 15 parts, Plumbum preparatium, 5 parts of Sanguis Draxonis, 20 parts of Caulis Spatholobis, 10 parts of Rhizoma Curcumae, 20 parts of Radix Et Rhizoma Rhei, 20 parts of Flos Trolliis, 10 parts of Herba Hieracii Umbellati, 15 parts of Herba Ecliptaes, 20 parts of Folium Microcoris paniculataes, 30 parts of Flos Loniceraes, 20 parts of Herba Andrographis, 10 parts of Caulis Polygoni Multiflori, 20 parts of Radix Sophorae Flavescentiss, 20 parts of Rhizoma Coptidis, 20 parts, Rhizoma Gastrodiae, 20 parts of Rhizoma Et Radix Notopterygiis, 20 parts of Radix Saposhnikoviaes, 20 parts of Herba Typhonii gigantei, 20 parts of Colophonium, 20 parts of Folium Isatidiss, 30 parts of husky Rhizoma Zingiberis Recens, 50 parts of Rhizoma Imperataes, 10 parts of Fructus Arctiis, 30 parts of Flos Chrysanthemis.
Ointment preparation method is as embodiment 1
Embodiment 3
The raw material of effective ingredient of the present invention forms and parts by weight are: 15 parts of Radix Notoginseng, 10 parts, Plumbum preparatium, 4 parts of Sanguis Draxonis, 10 parts of Caulis Spatholobis, 8 parts of Rhizoma Curcumae, 15 parts of Radix Et Rhizoma Rhei, 15 parts of Flos Trolliis, 8 parts of Herba Hieracii Umbellati, 10 parts of Herba Ecliptaes, 10 parts of Folium Microcoris paniculataes, 25 parts of Flos Loniceraes, 18 parts of Herba Andrographis, 8 parts of Caulis Polygoni Multiflori, 15 parts of Radix Sophorae Flavescentiss, 15 parts of Rhizoma Coptidis, 10 parts, Rhizoma Gastrodiae, 15 parts of Rhizoma Et Radix Notopterygiis, 15 parts of Radix Saposhnikoviaes, 20 parts of Herba Typhonii gigantei, 20 parts of Colophonium, 120 parts of Folium Isatidiss, 20 parts of husky Rhizoma Zingiberis Recens, 20 parts of Rhizoma Imperataes, 5 parts of Fructus Arctiis, 10 parts of Flos Chrysanthemis.
Ointment preparation method is as embodiment 1.
Toxicity test:
Choose 70 of SD rats, be divided into 35 every group of matched group, experimental grouies, male and female are suitable.Matched group adopts normal saline gavage, and experimental group adopts the present embodiment 1 ointment to be scattered in water, gavage, and its dosage is 400mg (crude drug) kg
-1, above homogeneous day three gavages, successive administration 10 weeks, observes the indexs such as animal ordinary circumstance and body weight.After drug withdrawal three days, observe the indexs such as hair, behavior, defecation, body weight and blood of rat.
Table 1 is rat hematological results
Comparing result shows all to have no significant effect.Put to death rat, its internal organs are carried out to tissue slice, Electronic Speculum contrast shows without any pathological changes and abnormal.Illustrate that toxicity is little after Chinese medicine of the present invention is to SD rat long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.
Clinical trial:
Choose by PICC and implant and cause cases of infection 84 examples.
Therapeutic scheme: external embodiment 1 ointment, within 1st, smear three times, within two weeks, be a course for the treatment of.
The standard of curative effect evaluation:
Cure: PICC implant site is without pain, and redness disappears, suppuration transference cure, the bright and clean high resilience of skin, body temperature is normal.
Effective: the pain relief of PICC implant site, swelling alleviates to some extent, and suppuration region reduces to some extent, and it is normal that body temperature is tending towards.
Invalid: symptom is not improved, even there is the trend of increasing the weight of, continue high heat, suppuration region area increases.
Therapeutic outcome: implanted to cause to infect to suffer from by PICC and cure 71 examples, account for 84.6%, effective 6 examples, account for 7.1%, and invalid 7 examples, account for 8.3%.
Case 1: grandson so-and-so, man, 47 years old, PICC implant site congestion and swelling pain, continue high heat, give Drug therapy of the present invention and fully recover after the course for the treatment of.
Case 2: Huang, female, 34 years old, PICC implant site congestion and swelling pain, there is suppuration symptom in part, is attended by exudate, and continue high heat, gives Drug therapy of the present invention and fully recover after two courses for the treatment of.
Case 3: field, man, 25 years old, the swelling of PICC implant site, itch, bitterly, desquamation, play measles, give Drug therapy of the present invention and fully recover after two courses for the treatment of.
The above; it is only most preferred embodiment of the present invention; not the present invention is done to any pro forma restriction; any those of ordinary skill in the art; do not departing from technical solution of the present invention scope situation; utilize the method content of above-mentioned announcement to make many possible changes and modification to technical solution of the present invention, all belong to the scope of claims protection.
Claims (5)
1. a traditional Chinese herb medicine for the treatment of PICC local infection, is characterized in that: each component by following parts by weight forms:
5～20 parts of Radix Notoginseng, 1～15 part, Plumbum preparatium, 1～5 part of Sanguis Draxonis, 5～20 parts of Caulis Spatholobis, 1～10 part of Rhizoma Curcumae, 10～20 parts of Radix Et Rhizoma Rhei, 10～20 parts of Flos Trolliis, 1～10 part of Herba Hieracii Umbellati, 5～15 parts of Herba Ecliptaes, 5～20 parts of Folium Microcoris paniculataes, 10～30 parts of Flos Loniceraes, 10～20 parts of Herba Andrographis, 1～10 part of Caulis Polygoni Multiflori, 5～20 parts of Radix Sophorae Flavescentiss, 5～20 parts of Rhizoma Coptidis, 1～20 part, Rhizoma Gastrodiae, 1～20 part of Rhizoma Et Radix Notopterygii, 5～20 parts of Radix Saposhnikoviaes, 1～20 part of Herba Typhonii gigantei, 5～20 parts of Colophonium, 1～20 part of Folium Isatidis, 1～30 part of husky Rhizoma Zingiberis Recens, 10～50 parts of Rhizoma Imperataes, 1～10 part of Fructus Arctii, 1～30 part of Flos Chrysanthemi.
2. a kind of traditional Chinese herb medicine for the treatment of PICC local infection according to claim 1, is characterized in that: each component by following parts by weight forms:
5～20 parts of Radix Notoginseng, 1～15 part, Plumbum preparatium, 1～5 part of Sanguis Draxonis, 5～20 parts of Caulis Spatholobis, 1～10 part of Rhizoma Curcumae, 10～20 parts of Radix Et Rhizoma Rhei, 10～20 parts of Flos Trolliis, 1～10 part of Herba Hieracii Umbellati, 5～15 parts of Herba Ecliptaes, 5～20 parts of Folium Microcoris paniculataes, 20～30 parts of Flos Loniceraes, 15～20 parts of Herba Andrographis, 5～10 parts of Caulis Polygoni Multiflori, 10～20 parts of Radix Sophorae Flavescentiss, 10～20 parts of Rhizoma Coptidis, 5～20 parts, Rhizoma Gastrodiae, 5～20 parts of Rhizoma Et Radix Notopterygiis, 10～20 parts of Radix Saposhnikoviaes, 10～20 parts of Herba Typhonii gigantei, 5～20 parts of Colophonium, 10～20 parts of Folium Isatidiss, 20～30 parts of husky Rhizoma Zingiberis Recens, 20～50 parts of Rhizoma Imperataes, 5～10 parts of Fructus Arctiis, 10～30 parts of Flos Chrysanthemis.
3. a kind of traditional Chinese herb medicine for the treatment of PICC local infection according to claim 1 and preparation method thereof, is characterized in that: comprise following processing step:
(1) Radix Notoginseng, Colophonium, Flos Trollii and Herba Hieracii Umbellati are cleaned, dried, pulverize, grind to form fine powder;
(2) Plumbum preparatium, Sanguis Draxonis, Caulis Spatholobi, Rhizoma Curcumae, Radix Et Rhizoma Rhei, Herba Ecliptae, Folium Microcoris paniculatae, Flos Lonicerae, Herba Andrographis, Caulis Polygoni Multiflori, Radix Sophorae Flavescentis, Rhizoma Coptidis, Rhizoma Gastrodiae, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae, Herba Typhonii gigantei, Folium Isatidis, husky Rhizoma Zingiberis Recens, Rhizoma Imperatae, Fructus Arctii and Flos Chrysanthemi are cleaned, dry, pulverize, cross 100 mesh sieves, decocting three times, merge three times filtrate, the concentrated extracted extract of getting angry;
(3) step (1) fine powder and step (2) extractum are ground to evenly jointly, add paste adjuvant, continue to be ground to into cream.
4. a kind of traditional Chinese herb medicine for the treatment of PICC local infection according to claim 3 and preparation method thereof, is characterized in that: the CO60 sterilizing of described fine powder and extractum, irradiation dose 8k.
5. a kind of traditional Chinese herb medicine for the treatment of PICC local infection according to claim 3 and preparation method thereof, is characterized in that: described paste adjuvant also comprises wetting agent, antiseptic, thickening agent, antioxidant and transdermal enhancer.
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| CN1197665A (en) * | 1998-05-08 | 1998-11-04 | 顾家富 | Ointment 'Yantongping' for relieving inflammatory pain and its preparation |
| CN102973800A (en) * | 2012-10-31 | 2013-03-20 | 河南牧翔动物药业有限公司 | Puffball compound coating agent and preparation method thereof |
| CN103655756A (en) * | 2013-11-26 | 2014-03-26 | 宋爱民 | External-use traditional Chinese medicine preparation for treating skin purulent infection |
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2014
- 2014-06-10 CN CN201410254949.4A patent/CN104001084A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1197665A (en) * | 1998-05-08 | 1998-11-04 | 顾家富 | Ointment 'Yantongping' for relieving inflammatory pain and its preparation |
| CN102973800A (en) * | 2012-10-31 | 2013-03-20 | 河南牧翔动物药业有限公司 | Puffball compound coating agent and preparation method thereof |
| CN103655756A (en) * | 2013-11-26 | 2014-03-26 | 宋爱民 | External-use traditional Chinese medicine preparation for treating skin purulent infection |
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| Title |
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| 宦丽萍: "独角膏在局部感染中的临床应用", 《中医中药》 * |
| 张采红等: "PICC 导管相关并发症的原因与防治进展", 《现代中西医结合杂志》 * |
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Application publication date: 20140827 |